EFCAB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.56991549
2myelination (GO:0042552)6.34694468
3axon ensheathment (GO:0008366)6.31882516
4ensheathment of neurons (GO:0007272)6.31882516
5long-chain fatty acid biosynthetic process (GO:0042759)5.71541116
6myelin maintenance (GO:0043217)5.37076233
7negative regulation of neurotransmitter secretion (GO:0046929)4.86911408
8negative regulation of neurotransmitter transport (GO:0051589)4.83003994
9negative regulation of protein localization to cell surface (GO:2000009)4.70694256
10photoreceptor cell differentiation (GO:0046530)4.62390943
11eye photoreceptor cell differentiation (GO:0001754)4.62390943
12cholesterol biosynthetic process (GO:0006695)4.56174773
13GPI anchor biosynthetic process (GO:0006506)4.46144361
14nucleotide transmembrane transport (GO:1901679)4.43498319
15oligodendrocyte differentiation (GO:0048709)4.34730044
16regulation of collateral sprouting (GO:0048670)4.30961254
17amyloid precursor protein metabolic process (GO:0042982)4.27200292
18preassembly of GPI anchor in ER membrane (GO:0016254)4.13103376
19GPI anchor metabolic process (GO:0006505)4.12125316
20sterol biosynthetic process (GO:0016126)4.10258902
21positive regulation of oligodendrocyte differentiation (GO:0048714)4.03061339
22L-amino acid import (GO:0043092)3.97927222
23signal peptide processing (GO:0006465)3.96883420
24response to redox state (GO:0051775)3.95906774
25response to methylmercury (GO:0051597)3.82590730
26creatine metabolic process (GO:0006600)3.76789327
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69107733
28isoprenoid biosynthetic process (GO:0008299)3.68693499
29response to lipoprotein particle (GO:0055094)3.68303268
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.67285625
31negative regulation of JUN kinase activity (GO:0043508)3.65688595
32magnesium ion transport (GO:0015693)3.63985598
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.63643115
34import into cell (GO:0098657)3.62535643
35glycerophospholipid catabolic process (GO:0046475)3.60079645
36regulation of lipoprotein metabolic process (GO:0050746)3.59902014
37negative regulation of cell killing (GO:0031342)3.48999102
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48999102
39presynaptic membrane organization (GO:0097090)3.46574826
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.42933174
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42856852
42substantia nigra development (GO:0021762)3.41753111
43peripheral nervous system axon ensheathment (GO:0032292)3.40486670
44myelination in peripheral nervous system (GO:0022011)3.40486670
45antigen processing and presentation of endogenous antigen (GO:0019883)3.32980089
46mannosylation (GO:0097502)3.31861906
47positive regulation of gamma-delta T cell activation (GO:0046645)3.30178169
48asymmetric protein localization (GO:0008105)3.29148355
49astrocyte development (GO:0014002)3.27693264
50nucleotide transport (GO:0006862)3.26779069
51negative regulation of erythrocyte differentiation (GO:0045647)3.24292433
52cerebral cortex radially oriented cell migration (GO:0021799)3.18890073
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18527476
54presynaptic membrane assembly (GO:0097105)3.18162104
55establishment of mitochondrion localization (GO:0051654)3.14770000
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13630160
57apical protein localization (GO:0045176)3.08792980
58negative regulation of execution phase of apoptosis (GO:1900118)3.08641968
59hypotonic response (GO:0006971)3.08015152
60enteric nervous system development (GO:0048484)3.06748339
61glycosylceramide metabolic process (GO:0006677)3.06738164
62amyloid precursor protein catabolic process (GO:0042987)3.03779915
63fatty-acyl-CoA biosynthetic process (GO:0046949)3.01570277
64limb bud formation (GO:0060174)2.99882736
65leukocyte migration involved in inflammatory response (GO:0002523)2.98486074
66protein palmitoylation (GO:0018345)2.98473956
67endothelium development (GO:0003158)2.94799797
68cranial nerve development (GO:0021545)2.93154605
69amino acid import (GO:0043090)2.92381019
70positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.91757048
71fatty-acyl-CoA metabolic process (GO:0035337)2.91715537
72very long-chain fatty acid metabolic process (GO:0000038)2.87882213
73protein neddylation (GO:0045116)2.87407472
74membrane tubulation (GO:0097320)2.84846079
75C-terminal protein lipidation (GO:0006501)2.83928878
76interleukin-6-mediated signaling pathway (GO:0070102)2.82171870
77ER overload response (GO:0006983)2.81883144
78adhesion of symbiont to host cell (GO:0044650)2.81041230
79virion attachment to host cell (GO:0019062)2.81041230
80organ growth (GO:0035265)2.81016411
81detection of other organism (GO:0098543)2.79087370
82Golgi to plasma membrane protein transport (GO:0043001)2.75579173
83regulation of gamma-delta T cell differentiation (GO:0045586)2.74091372
84surfactant homeostasis (GO:0043129)2.73683184
85neurotransmitter uptake (GO:0001504)2.71684283
86protein localization to endosome (GO:0036010)2.70676323
87regulation of gamma-delta T cell activation (GO:0046643)2.70541128
88Golgi to endosome transport (GO:0006895)2.70126905
89positive regulation of glial cell differentiation (GO:0045687)2.67589441
90negative regulation of myoblast differentiation (GO:0045662)2.66852968
91membrane protein ectodomain proteolysis (GO:0006509)2.66337876
92detection of bacterium (GO:0016045)2.66014425
93glycolipid biosynthetic process (GO:0009247)2.65734901
94membrane raft organization (GO:0031579)2.63491548
95response to epinephrine (GO:0071871)2.62445334
96cellular response to hepatocyte growth factor stimulus (GO:0035729)2.60046297
97response to hepatocyte growth factor (GO:0035728)2.60046297
98neutrophil activation involved in immune response (GO:0002283)2.57778479
99regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.57268364
100neuron remodeling (GO:0016322)2.56765321
101estrogen biosynthetic process (GO:0006703)2.56110777
102regulation of somitogenesis (GO:0014807)2.56073751
103positive regulation of Rap GTPase activity (GO:0032854)2.55755930
104positive regulation of gliogenesis (GO:0014015)2.55287946
105glial cell development (GO:0021782)2.54336854
106cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.52789365
107peripheral nervous system development (GO:0007422)2.52425964
108barbed-end actin filament capping (GO:0051016)2.52201842
109cellular response to thyroid hormone stimulus (GO:0097067)2.52002189
110water-soluble vitamin biosynthetic process (GO:0042364)2.51816723
111positive regulation of cellular amine metabolic process (GO:0033240)2.50858661
112protein lipidation (GO:0006497)2.50328251
113response to laminar fluid shear stress (GO:0034616)2.48470402
114positive regulation of actin filament depolymerization (GO:0030836)2.47423399
115microtubule polymerization or depolymerization (GO:0031109)2.46295577
116negative regulation of chemokine production (GO:0032682)2.45682673
117regulation of feeding behavior (GO:0060259)2.44832215
118membrane lipid biosynthetic process (GO:0046467)2.42786843
119positive regulation of cellular amide metabolic process (GO:0034250)2.42357859
120tissue regeneration (GO:0042246)2.41687214
121carbohydrate derivative transport (GO:1901264)2.40496875
122regulation of B cell receptor signaling pathway (GO:0050855)2.39565773
123negative regulation of protein localization to plasma membrane (GO:1903077)2.39340590
124positive regulation of receptor recycling (GO:0001921)2.36212891
125positive thymic T cell selection (GO:0045059)2.35120299
126Golgi transport vesicle coating (GO:0048200)2.32983143
127COPI coating of Golgi vesicle (GO:0048205)2.32983143
128peptide catabolic process (GO:0043171)2.31846941
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.31055848
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.31055848
131modulation by symbiont of host immune response (GO:0052553)2.31055848
132positive regulation by symbiont of host defense response (GO:0052509)2.31055848
133modulation by symbiont of host defense response (GO:0052031)2.31055848
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.31055848
135detection of external biotic stimulus (GO:0098581)2.30499480
136response to thyroid hormone (GO:0097066)2.27740977
137macrophage activation involved in immune response (GO:0002281)2.27681624
138regulation of extracellular matrix disassembly (GO:0010715)2.26904274
139regulation of necroptotic process (GO:0060544)2.26492716
140pinocytosis (GO:0006907)2.25934245
141growth hormone receptor signaling pathway (GO:0060396)2.25735823
142negative thymic T cell selection (GO:0045060)2.24469336
143embryonic process involved in female pregnancy (GO:0060136)2.24091992
144COPII vesicle coating (GO:0048208)2.23167548
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.22207169
146negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.21112924
147germinal center formation (GO:0002467)2.20842283
148stress fiber assembly (GO:0043149)2.20253666
149thymic T cell selection (GO:0045061)2.19970064
150desmosome organization (GO:0002934)2.18163604
151Rap protein signal transduction (GO:0032486)2.17846060
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.17753136
153T cell selection (GO:0045058)2.17285996
154negative regulation of glycoprotein biosynthetic process (GO:0010561)2.17125430
155mannose metabolic process (GO:0006013)2.16922191
156negative T cell selection (GO:0043383)2.15761354
157definitive hemopoiesis (GO:0060216)2.15698785
158establishment of endothelial barrier (GO:0061028)2.15416934
159angiogenesis involved in wound healing (GO:0060055)2.10769684
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.09634355
161negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.08889950
162B cell receptor signaling pathway (GO:0050853)2.08273930
163regulation of early endosome to late endosome transport (GO:2000641)2.08272531
164regulation of lipid kinase activity (GO:0043550)2.08202224
165macroautophagy (GO:0016236)2.08021524
166negative regulation of stress fiber assembly (GO:0051497)2.07001754
167regulation of leukocyte degranulation (GO:0043300)2.06636719
168detection of molecule of bacterial origin (GO:0032490)2.06249633
169positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.05452222
170antigen processing and presentation via MHC class Ib (GO:0002475)2.04612302
171phospholipid scrambling (GO:0017121)2.04104869
172iron ion import (GO:0097286)2.03254202
173cellular response to reactive nitrogen species (GO:1902170)2.02609679
174cell volume homeostasis (GO:0006884)2.02478514
175regulation of transforming growth factor beta1 production (GO:0032908)2.02209097
176regulation of dendritic cell antigen processing and presentation (GO:0002604)2.02132371
177regulation of T-helper 2 cell differentiation (GO:0045628)2.00239704
178axon ensheathment in central nervous system (GO:0032291)11.7633529
179central nervous system myelination (GO:0022010)11.7633529
180response to peptidoglycan (GO:0032494)1.97836507
181response to muramyl dipeptide (GO:0032495)1.97794406
182platelet-derived growth factor receptor signaling pathway (GO:0048008)1.97425757
183regulation of Rap GTPase activity (GO:0032317)1.97099614
184megakaryocyte development (GO:0035855)1.95528849
185regulation of water loss via skin (GO:0033561)1.95231968
186positive regulation of adherens junction organization (GO:1903393)1.95024333
187regulation of ARF protein signal transduction (GO:0032012)1.94878448
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.94864209
189response to host (GO:0075136)1.94864209
190response to host defenses (GO:0052200)1.94864209
191cellular response to growth hormone stimulus (GO:0071378)1.94848101
192cellular response to type I interferon (GO:0071357)1.94752686
193type I interferon signaling pathway (GO:0060337)1.94752686
194histone H3-K36 demethylation (GO:0070544)1.94451528
195response to type I interferon (GO:0034340)1.93185241
196positive T cell selection (GO:0043368)1.92834678
197chemical homeostasis within a tissue (GO:0048875)1.92806382
198skin morphogenesis (GO:0043589)1.92720067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31285873
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.17409292
3GBX2_23144817_ChIP-Seq_PC3_Human2.94408986
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84240196
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.76084986
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.72359481
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61132228
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51305601
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39441612
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.38863326
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38595586
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38498374
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36272988
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35014228
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24445745
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23831118
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.23072924
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22880675
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21699429
20VDR_22108803_ChIP-Seq_LS180_Human2.14174329
21TAF15_26573619_Chip-Seq_HEK293_Human2.07136706
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06325594
23RUNX_20019798_ChIP-Seq_JUKART_Human2.04688182
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03250791
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.02406089
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01681745
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01504853
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94557933
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91854805
30GATA1_22025678_ChIP-Seq_K562_Human1.89434931
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86861864
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.82038257
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.78633570
34SCL_19346495_ChIP-Seq_HPC-7_Human1.76188272
35CLOCK_20551151_ChIP-Seq_293T_Human1.73635411
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71977587
37FUS_26573619_Chip-Seq_HEK293_Human1.69657731
38ER_23166858_ChIP-Seq_MCF-7_Human1.69617408
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.67092766
40SPI1_23127762_ChIP-Seq_K562_Human1.63335467
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62343391
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62240627
43IGF1R_20145208_ChIP-Seq_DFB_Human1.61159709
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.60904367
45P300_19829295_ChIP-Seq_ESCs_Human1.60745283
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59841535
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59841535
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59255419
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.58649195
50LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57932318
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57143984
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55418107
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54090939
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53953104
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53152893
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52960044
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.52736394
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52390332
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51543993
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51450790
61TCF7_22412390_ChIP-Seq_EML_Mouse1.51206411
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49933962
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.49904867
64GATA1_19941826_ChIP-Seq_K562_Human1.49401707
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49035182
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47975316
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47753651
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47335761
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46562517
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46562517
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.45738063
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45691410
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45097816
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45076273
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.44982944
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43740069
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.43273380
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43244957
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.42629699
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.41425376
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.41425376
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41329060
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.39823156
84VDR_24787735_ChIP-Seq_THP-1_Human1.39415710
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39199284
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39149985
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.38500939
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38141120
89AR_21572438_ChIP-Seq_LNCaP_Human1.37590577
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37321058
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.36893453
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.35534791
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35450229
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35228088
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.34922502
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34355460
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33837264
98P300_18555785_Chip-Seq_ESCs_Mouse1.32341653
99P53_22387025_ChIP-Seq_ESCs_Mouse1.32327683
100STAT3_23295773_ChIP-Seq_U87_Human1.32050538
101LXR_22158963_ChIP-Seq_LIVER_Mouse1.32036061
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31590181
103MYB_26560356_Chip-Seq_TH2_Human1.31496573
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31113999
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.30360280
106VDR_24763502_ChIP-Seq_THP-1_Human1.29144719
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.29028330
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28997130
109SOX2_20726797_ChIP-Seq_SW620_Human1.28672066
110MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28599154
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27690156
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27502021
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.27408480
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27287478
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27136712
116EWS_26573619_Chip-Seq_HEK293_Human1.25898357
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25486343
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24719037
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.24575588
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.24420023
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24304422
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.23899693
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23590607
124GATA2_19941826_ChIP-Seq_K562_Human1.23122701
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22214637
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.21921395
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.20634808
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20579464
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18686658
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18659424
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18658896
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18191530
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17893228
134RXR_22158963_ChIP-Seq_LIVER_Mouse1.17604083
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17532481
136SMAD_19615063_ChIP-ChIP_OVARY_Human1.17190927
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17172796
138MYB_26560356_Chip-Seq_TH1_Human1.16604656
139SMAD4_21799915_ChIP-Seq_A2780_Human1.16562051
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16230235
141SOX2_18555785_Chip-Seq_ESCs_Mouse1.15729880
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15172614
143RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15115023
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14828978
145NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14297150
146IRF1_19129219_ChIP-ChIP_H3396_Human1.14275371
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13817886
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13130697
149STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13078328
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.12688902
151RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12626024
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12615440
153RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12279102
154EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12279102
155TCF4_23295773_ChIP-Seq_U87_Human1.11535431
156CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11455247
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11232377
158RNF2_27304074_Chip-Seq_ESCs_Mouse1.10522861
159MAF_26560356_Chip-Seq_TH1_Human1.10315856
160NMYC_18555785_Chip-Seq_ESCs_Mouse1.10103974
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09572679
162OCT4_18555785_Chip-Seq_ESCs_Mouse1.09320637
163SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09069401
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08243700
165SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07947921
166IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07539335
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07334785
168SOX2_19829295_ChIP-Seq_ESCs_Human1.07301191
169NANOG_19829295_ChIP-Seq_ESCs_Human1.07301191
170PU_27001747_Chip-Seq_BMDM_Mouse1.06697386
171EZH2_27294783_Chip-Seq_ESCs_Mouse1.06483142
172KLF4_18555785_Chip-Seq_ESCs_Mouse1.05723561
173AHR_22903824_ChIP-Seq_MCF-7_Human1.04835277
174RNF2_27304074_Chip-Seq_NSC_Mouse1.04659785
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04613153
176CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03786523
177CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03777436
178KDM2B_26808549_Chip-Seq_DND41_Human1.03668102
179P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03311804
180KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02373821
181E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01898921
182GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00624162
183RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00375016
184FOXA2_19822575_ChIP-Seq_HepG2_Human0.99405905
185GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98307489
186ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98185442
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95425399
188PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94625988
189GATA3_27048872_Chip-Seq_THYMUS_Human0.93299537
190P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93287466
191TP63_23658742_ChIP-Seq_EP156T_Human0.92588193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.41808534
2MP0003950_abnormal_plasma_membrane4.04346938
3MP0005171_absent_coat_pigmentation3.74115872
4MP0003136_yellow_coat_color3.54848604
5MP0003300_gastrointestinal_ulcer3.14327787
6MP0003690_abnormal_glial_cell3.03876921
7MP0005409_darkened_coat_color2.94090354
8MP0010234_abnormal_vibrissa_follicle2.84155377
9MP0004885_abnormal_endolymph2.64890966
10MP0003191_abnormal_cellular_cholesterol2.62242742
11MP0004043_abnormal_pH_regulation2.60806423
12MP0001905_abnormal_dopamine_level2.57822659
13MP0003724_increased_susceptibility_to2.52322254
14MP0001529_abnormal_vocalization2.51843141
15MP0001485_abnormal_pinna_reflex2.49116488
16MP0001986_abnormal_taste_sensitivity2.45969286
17MP0003303_peritoneal_inflammation2.37952931
18MP0000566_synostosis2.37381931
19MP0003634_abnormal_glial_cell2.21243054
20MP0004742_abnormal_vestibular_system2.18279826
21MP0003828_pulmonary_edema2.16291851
22MP0004147_increased_porphyrin_level2.06928743
23MP0010368_abnormal_lymphatic_system2.04301039
24MP0003705_abnormal_hypodermis_morpholog2.02141021
25MP0010352_gastrointestinal_tract_polyps1.98751201
26MP0004270_analgesia1.98230009
27MP0005275_abnormal_skin_tensile1.96672423
28MP0003880_abnormal_central_pattern1.96238949
29MP0003566_abnormal_cell_adhesion1.93776254
30MP0004142_abnormal_muscle_tone1.93614742
31MP0001486_abnormal_startle_reflex1.91371154
32MP0004134_abnormal_chest_morphology1.90330072
33MP0003763_abnormal_thymus_physiology1.90066156
34MP0003436_decreased_susceptibility_to1.86859565
35MP0003091_abnormal_cell_migration1.85484590
36MP0000383_abnormal_hair_follicle1.84546911
37MP0000462_abnormal_digestive_system1.81687526
38MP0010678_abnormal_skin_adnexa1.81557998
39MP0001835_abnormal_antigen_presentation1.80636152
40MP0002272_abnormal_nervous_system1.78875338
41MP0002938_white_spotting1.78687002
42MP0002796_impaired_skin_barrier1.76927031
43MP0004381_abnormal_hair_follicle1.74056823
44MP0008004_abnormal_stomach_pH1.73559720
45MP0009840_abnormal_foam_cell1.72910339
46MP0001346_abnormal_lacrimal_gland1.71101147
47MP0004947_skin_inflammation1.70560826
48MP0008438_abnormal_cutaneous_collagen1.70357248
49MP0002166_altered_tumor_susceptibility1.66645346
50MP0000372_irregular_coat_pigmentation1.64701826
51MP0003632_abnormal_nervous_system1.63754034
52MP0005464_abnormal_platelet_physiology1.60745475
53MP0002229_neurodegeneration1.57865930
54MP0009780_abnormal_chondrocyte_physiolo1.52482983
55MP0010155_abnormal_intestine_physiology1.51829387
56MP0003453_abnormal_keratinocyte_physiol1.51372566
57MP0002009_preneoplasia1.51188250
58MP0006082_CNS_inflammation1.46404665
59MP0002998_abnormal_bone_remodeling1.44432064
60MP0001958_emphysema1.44397490
61MP0005408_hypopigmentation1.43858384
62MP0003195_calcinosis1.42781765
63MP0002419_abnormal_innate_immunity1.42540838
64MP0003329_amyloid_beta_deposits1.42439119
65MP0003279_aneurysm1.40386263
66MP0001790_abnormal_immune_system1.38557599
67MP0005387_immune_system_phenotype1.38557599
68MP0005000_abnormal_immune_tolerance1.37416059
69MP0005646_abnormal_pituitary_gland1.36572914
70MP0000749_muscle_degeneration1.36469504
71MP0000778_abnormal_nervous_system1.36467406
72MP0005379_endocrine/exocrine_gland_phen1.35493686
73MP0005423_abnormal_somatic_nervous1.34572113
74MP0005410_abnormal_fertilization1.34444154
75MP0005023_abnormal_wound_healing1.32768113
76MP0004264_abnormal_extraembryonic_tissu1.32759736
77MP0001533_abnormal_skeleton_physiology1.31907237
78MP0006054_spinal_hemorrhage1.31844346
79MP0003631_nervous_system_phenotype1.31047742
80MP0005451_abnormal_body_composition1.28869676
81MP0003045_fibrosis1.27448023
82MP0000685_abnormal_immune_system1.26959594
83MP0005025_abnormal_response_to1.25018448
84MP0001963_abnormal_hearing_physiology1.22641621
85MP0008260_abnormal_autophagy1.20509213
86MP0001800_abnormal_humoral_immune1.19262489
87MP0005645_abnormal_hypothalamus_physiol1.17352012
88MP0002405_respiratory_system_inflammati1.16325889
89MP0005165_increased_susceptibility_to1.16156795
90MP0002064_seizures1.15015449
91MP0005166_decreased_susceptibility_to1.14936207
92MP0003633_abnormal_nervous_system1.13940035
93MP0005058_abnormal_lysosome_morphology1.13837932
94MP0002452_abnormal_antigen_presenting1.12401988
95MP0002723_abnormal_immune_serum1.11581057
96MP0001188_hyperpigmentation1.10984388
97MP0000762_abnormal_tongue_morphology1.10889455
98MP0001879_abnormal_lymphatic_vessel1.10536915
99MP0005551_abnormal_eye_electrophysiolog1.09895331
100MP0002420_abnormal_adaptive_immunity1.09833507
101MP0003172_abnormal_lysosome_physiology1.09597609
102MP0001819_abnormal_immune_cell1.09099690
103MP0004782_abnormal_surfactant_physiolog1.08512989
104MP0004484_altered_response_of1.07775613
105MP0003656_abnormal_erythrocyte_physiolo1.07748161
106MP0009250_abnormal_appendicular_skeleto1.07448007
107MP0001851_eye_inflammation1.07227361
108MP0003937_abnormal_limbs/digits/tail_de1.07115389
109MP0002148_abnormal_hypersensitivity_rea1.05773763
110MP0008569_lethality_at_weaning1.03749843
111MP0003866_abnormal_defecation1.03742878
112MP0000249_abnormal_blood_vessel1.03633615
113MP0009785_altered_susceptibility_to1.02877156
114MP0002734_abnormal_mechanical_nocicepti1.02813503
115MP0005666_abnormal_adipose_tissue1.02616864
116MP0005164_abnormal_response_to1.01924535
117MP0002060_abnormal_skin_morphology1.01579712
118MP0000647_abnormal_sebaceous_gland1.01454752
119MP0002396_abnormal_hematopoietic_system1.00679974
120MP0001177_atelectasis1.00319751
121MP0002006_tumorigenesis0.99992807
122MP0004808_abnormal_hematopoietic_stem0.97710356
123MP0000858_altered_metastatic_potential0.97697250
124MP0001299_abnormal_eye_distance/0.96846162
125MP0002163_abnormal_gland_morphology0.96692281
126MP0004036_abnormal_muscle_relaxation0.95743713
127MP0000465_gastrointestinal_hemorrhage0.95406007
128MP0005375_adipose_tissue_phenotype0.95050368
129MP0000767_abnormal_smooth_muscle0.94426045
130MP0001845_abnormal_inflammatory_respons0.93414967
131MP0009333_abnormal_splenocyte_physiolog0.93134078
132MP0003075_altered_response_to0.92730579
133MP0002138_abnormal_hepatobiliary_system0.92551970
134MP0000026_abnormal_inner_ear0.91896162
135MP0006138_congestive_heart_failure0.90391668
136MP0003806_abnormal_nucleotide_metabolis0.89527632
137MP0002398_abnormal_bone_marrow0.89521151
138MP0004185_abnormal_adipocyte_glucose0.89450758
139MP0004883_abnormal_blood_vessel0.88920921
140MP0001216_abnormal_epidermal_layer0.88700229
141MP0005501_abnormal_skin_physiology0.87729409
142MP0000003_abnormal_adipose_tissue0.87245884
143MP0005671_abnormal_response_to0.86985911
144MP0002295_abnormal_pulmonary_circulatio0.86752490
145MP0005195_abnormal_posterior_eye0.86623440
146MP0004084_abnormal_cardiac_muscle0.85870437
147MP0002882_abnormal_neuron_morphology0.84859095
148MP0000579_abnormal_nail_morphology0.84711846
149MP0005253_abnormal_eye_physiology0.84457256
150MP0003448_altered_tumor_morphology0.84058566
151MP0001545_abnormal_hematopoietic_system0.83588255
152MP0005397_hematopoietic_system_phenotyp0.83588255
153MP0000716_abnormal_immune_system0.83013015
154MP0001502_abnormal_circadian_rhythm0.82883077
155MP0000015_abnormal_ear_pigmentation0.82683955
156MP0005167_abnormal_blood-brain_barrier0.82346222
157MP0002752_abnormal_somatic_nervous0.81780851
158MP0005310_abnormal_salivary_gland0.81521739
159MP0002896_abnormal_bone_mineralization0.81279707
160MP0003183_abnormal_peptide_metabolism0.81237961
161MP0000613_abnormal_salivary_gland0.80884334
162MP0002133_abnormal_respiratory_system0.80780459
163MP0005388_respiratory_system_phenotype0.80780459
164MP0002971_abnormal_brown_adipose0.80544009
165MP0004145_abnormal_muscle_electrophysio0.78369648
166MP0000955_abnormal_spinal_cord0.77859834
167MP0000631_abnormal_neuroendocrine_gland0.77346239
168MP0005075_abnormal_melanosome_morpholog0.76572245
169MP0009384_cardiac_valve_regurgitation0.75424222
170MP0005623_abnormal_meninges_morphology0.71349490
171MP0006072_abnormal_retinal_apoptosis0.70244362
172MP0009697_abnormal_copulation0.69966351
173MP0002877_abnormal_melanocyte_morpholog0.69140379
174MP0002933_joint_inflammation0.67867852
175MP0002066_abnormal_motor_capabilities/c0.67311592
176MP0002132_abnormal_respiratory_system0.67307303
177MP0009745_abnormal_behavioral_response0.66475255
178MP0006292_abnormal_olfactory_placode0.66004984
179MP0001664_abnormal_digestion0.64691714
180MP0009046_muscle_twitch0.64625672
181MP0003787_abnormal_imprinting0.62815229
182MP0002067_abnormal_sensory_capabilities0.62636832
183MP0000604_amyloidosis0.62429414
184MP0004272_abnormal_basement_membrane0.61829828
185MP0004924_abnormal_behavior0.61595377
186MP0005386_behavior/neurological_phenoty0.61595377
187MP0000639_abnormal_adrenal_gland0.61006341

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.24189986
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.24189986
3Neurofibrillary tangles (HP:0002185)4.43997466
4Parakeratosis (HP:0001036)3.99945437
5Abnormality of the corticospinal tract (HP:0002492)3.94857551
6White forelock (HP:0002211)3.93995492
7Patchy hypopigmentation of hair (HP:0011365)3.93466720
8Peripheral hypomyelination (HP:0007182)3.57966744
9Eczematoid dermatitis (HP:0000976)3.57612623
10Sensory axonal neuropathy (HP:0003390)3.49569224
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38082137
12Abnormal auditory evoked potentials (HP:0006958)3.15819240
13Methylmalonic acidemia (HP:0002912)3.10392698
14Retinal dysplasia (HP:0007973)3.04429725
15Onion bulb formation (HP:0003383)2.97010878
16Spontaneous hematomas (HP:0007420)2.96498258
17Alacrima (HP:0000522)2.93677892
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77583715
19Anteriorly placed anus (HP:0001545)2.76910458
20Cerebral hypomyelination (HP:0006808)2.74511126
21Metabolic alkalosis (HP:0200114)2.73242250
22Adrenal hypoplasia (HP:0000835)2.70392277
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.68276168
24Osteolytic defects of the hand bones (HP:0009699)2.68276168
25Premature skin wrinkling (HP:0100678)2.68127627
26Aortic aneurysm (HP:0004942)2.63538288
27Increased circulating renin level (HP:0000848)2.62692900
28Aplasia involving bones of the upper limbs (HP:0009823)2.59618574
29Aplasia of the phalanges of the hand (HP:0009802)2.59618574
30Aplasia involving bones of the extremities (HP:0009825)2.59618574
31Hypomagnesemia (HP:0002917)2.59453960
32Hypokalemic alkalosis (HP:0001949)2.58546818
33Morphological abnormality of the inner ear (HP:0011390)2.55710132
34Arterial tortuosity (HP:0005116)2.54038586
35Increased IgE level (HP:0003212)2.53205643
36Abnormality of the phalanges of the 2nd finger (HP:0009541)2.52228905
37Leukodystrophy (HP:0002415)2.52075387
38Absent septum pellucidum (HP:0001331)2.52044658
39Insidious onset (HP:0003587)2.50719575
40Termporal pattern (HP:0011008)2.50719575
41Segmental peripheral demyelination/remyelination (HP:0003481)2.50672072
42Interstitial pulmonary disease (HP:0006530)2.49239664
43Autoamputation (HP:0001218)2.48556937
44Congenital ichthyosiform erythroderma (HP:0007431)2.46496087
45Vascular tortuosity (HP:0004948)2.45427734
46Abnormal hair whorl (HP:0010721)2.45188172
47Hyporeflexia of lower limbs (HP:0002600)2.42118415
48Abnormality of glycolipid metabolism (HP:0010969)2.40975981
49Abnormality of liposaccharide metabolism (HP:0010968)2.40975981
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.40975981
51Cupped ear (HP:0000378)2.39849714
52Cerebral inclusion bodies (HP:0100314)2.37186226
53Dysostosis multiplex (HP:0000943)2.36709814
54Renal Fanconi syndrome (HP:0001994)2.35229674
55Right ventricular cardiomyopathy (HP:0011663)2.34701924
56Congenital sensorineural hearing impairment (HP:0008527)2.33616028
57Abnormality of incisor morphology (HP:0011063)2.31805975
58Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31346039
59Stridor (HP:0010307)2.31009943
60Abnormality of glycolysis (HP:0004366)2.28638740
61Increased serum pyruvate (HP:0003542)2.28638740
62Recurrent abscess formation (HP:0002722)2.28509783
63Scanning speech (HP:0002168)2.28255366
64Intention tremor (HP:0002080)2.27078327
65Spastic gait (HP:0002064)2.25586810
66Slow saccadic eye movements (HP:0000514)2.22405686
67Aortic dissection (HP:0002647)2.21947120
68Cerebral aneurysm (HP:0004944)2.20483057
69Decreased lacrimation (HP:0000633)2.18364818
70Asymmetric septal hypertrophy (HP:0001670)2.18261302
71Gingivitis (HP:0000230)2.17844054
72Abnormality of skeletal muscle fiber size (HP:0012084)2.17777051
73Abnormality of the septum pellucidum (HP:0007375)2.17667877
74Abnormality of macrophages (HP:0004311)2.16114014
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.13706709
76Hypothermia (HP:0002045)2.13533196
77Hypoplasia of the iris (HP:0007676)2.12508304
78Hepatosplenomegaly (HP:0001433)2.11593360
79Increased variability in muscle fiber diameter (HP:0003557)2.09565577
80Gingival bleeding (HP:0000225)2.09521118
81Aneurysm (HP:0002617)2.07220040
82Recurrent bacterial skin infections (HP:0005406)2.07080006
83Malnutrition (HP:0004395)2.07023541
84Distal lower limb muscle weakness (HP:0009053)2.06759646
85Hypoplastic left heart (HP:0004383)2.06741303
86Megalencephaly (HP:0001355)2.06011126
87Loss of speech (HP:0002371)2.05676754
88Hypoplastic pelvis (HP:0008839)2.05254844
89Pancreatic islet-cell hyperplasia (HP:0004510)2.05011286
90Vertebral compression fractures (HP:0002953)2.04056266
91Hematochezia (HP:0002573)2.03713852
92Partial duplication of thumb phalanx (HP:0009944)2.03105106
93Prolonged bleeding time (HP:0003010)2.03073449
94Vaginal atresia (HP:0000148)2.01738844
95Urinary glycosaminoglycan excretion (HP:0003541)2.01282798
96Mucopolysacchariduria (HP:0008155)2.01282798
97Exercise-induced myalgia (HP:0003738)2.00188329
98Nonprogressive disorder (HP:0003680)1.97847278
99Conjunctival telangiectasia (HP:0000524)1.97709341
100Thickened helices (HP:0000391)1.97573101
101Dilatation of the ascending aorta (HP:0005111)1.97442492
102Epistaxis (HP:0000421)1.96650598
103Muscle hypertrophy of the lower extremities (HP:0008968)1.96519403
104Papillary thyroid carcinoma (HP:0002895)1.96341621
105Polycythemia (HP:0001901)1.95896380
106Increased CSF protein (HP:0002922)1.94869963
107Genital tract atresia (HP:0001827)1.94650933
108Progressive neurologic deterioration (HP:0002344)1.93311754
109Hyperactive renin-angiotensin system (HP:0000841)1.92306786
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91840332
111Systemic lupus erythematosus (HP:0002725)1.90718282
112Abnormal drinking behavior (HP:0030082)1.90404219
113Polydipsia (HP:0001959)1.90404219
114Supranuclear gaze palsy (HP:0000605)1.90241399
115Protrusio acetabuli (HP:0003179)1.89513855
116Mitral stenosis (HP:0001718)1.89077121
117Abnormality of magnesium homeostasis (HP:0004921)1.87883062
118Spondylolisthesis (HP:0003302)1.87794926
119Large for gestational age (HP:0001520)1.86693847
120Clumsiness (HP:0002312)1.86072750
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85420348
122Abnormality of polysaccharide metabolism (HP:0011012)1.85420348
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85420348
124Tetraparesis (HP:0002273)1.84728794
125Gastrointestinal infarctions (HP:0005244)1.84090079
126Enlarged epiphyses (HP:0010580)1.84063544
127Myositis (HP:0100614)1.83392235
128Pheochromocytoma (HP:0002666)1.83376915
129Esophageal varix (HP:0002040)1.83319920
130Cellulitis (HP:0100658)1.83294950
131Abnormality of the middle phalanges of the toes (HP:0010183)1.82861169
132Chest pain (HP:0100749)1.82570719
133Synostosis involving the elbow (HP:0003938)1.81801532
134Humeroradial synostosis (HP:0003041)1.81801532
135Fatigue (HP:0012378)1.80232972
136Increased connective tissue (HP:0009025)1.79782373
137Flat acetabular roof (HP:0003180)1.79179414
138Osteomyelitis (HP:0002754)1.78867376
139Metaphyseal dysplasia (HP:0100255)1.78809260
140Stomach cancer (HP:0012126)1.78580391
141CNS hypomyelination (HP:0003429)1.78235805
142T lymphocytopenia (HP:0005403)1.78180799
143Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76987149
144Bell-shaped thorax (HP:0001591)1.76816634
145Colitis (HP:0002583)1.76296126
146Dysmetria (HP:0001310)1.74537295
147Amyloidosis (HP:0011034)1.73980234
148Myocardial infarction (HP:0001658)1.72630815
149Abnormality of renal resorption (HP:0011038)1.72574573
150Orchitis (HP:0100796)1.72562416
151Infantile muscular hypotonia (HP:0008947)1.72293466
152Acute necrotizing encephalopathy (HP:0006965)1.72252076
153Chronic diarrhea (HP:0002028)1.71904046
154Gowers sign (HP:0003391)1.71687158
155Abnormality of the heme biosynthetic pathway (HP:0010472)1.70693455
156Ankyloglossia (HP:0010296)1.70307657
157Ankle clonus (HP:0011448)1.70270049
158Steppage gait (HP:0003376)1.70006208
159Subacute progressive viral hepatitis (HP:0006572)1.69139493
160Cerebral hemorrhage (HP:0001342)1.69003844
161Coarse hair (HP:0002208)1.68921912
162Autoimmune hemolytic anemia (HP:0001890)1.68181658
163Hypoplastic heart (HP:0001961)1.68146304
164Inflammation of the large intestine (HP:0002037)1.67229052
165Long nose (HP:0003189)1.67012284
166Muscle fiber splitting (HP:0003555)1.66823367
167Glucose intolerance (HP:0000833)1.66721375
168Partial duplication of the phalanx of hand (HP:0009999)1.66463349
169Nasolacrimal duct obstruction (HP:0000579)1.65799791
170Coronal craniosynostosis (HP:0004440)1.65764808
171Poor speech (HP:0002465)1.65074781
172Papilledema (HP:0001085)1.64699490
173Type II lissencephaly (HP:0007260)1.64623028
174Abnormality of the vitamin B12 metabolism (HP:0004341)1.63464810
175Abnormality of T cell number (HP:0011839)1.62862575
176Spastic paraparesis (HP:0002313)1.62749921
177Abnormal platelet volume (HP:0011876)1.62509774
178Abnormality of molar morphology (HP:0011070)1.62284665
179Abnormality of molar (HP:0011077)1.62284665
180Cranial hyperostosis (HP:0004437)1.61605211
181Periodontitis (HP:0000704)1.61267638
182Striae distensae (HP:0001065)1.61105008
183Cardiovascular calcification (HP:0011915)1.60953728
184Gastrointestinal inflammation (HP:0004386)1.58134157
185Craniofacial hyperostosis (HP:0004493)1.56571303
186Vascular calcification (HP:0004934)1.55989641
187Abnormality of monocarboxylic acid metabolism (HP:0010996)1.55633745
188Abnormal glucose tolerance (HP:0001952)1.55261259
189Atrioventricular block (HP:0001678)1.54963507
190Growth hormone excess (HP:0000845)1.54835692
191Hyperkalemia (HP:0002153)1.54626007
192Arterial thrombosis (HP:0004420)1.54167150
193Pulmonary infiltrates (HP:0002113)1.52987004
194Abnormality of oral frenula (HP:0000190)1.52741035
195Thick nail (HP:0001805)1.51689221
196Thin bony cortex (HP:0002753)1.51202592
197Distal lower limb amyotrophy (HP:0008944)1.51176220
198Increased mean platelet volume (HP:0011877)1.50951077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.65281020
2OXSR13.76923073
3EPHB13.54268836
4MAPKAPK53.01000346
5BCR2.72607502
6MAP3K132.60616170
7ERN12.45783120
8MUSK2.43628702
9PKN12.37240316
10PBK2.34211657
11WNK42.22966830
12RIPK12.22810418
13RIPK42.22669917
14NEK62.16497143
15TNIK2.12068632
16JAK12.02670882
17TYK22.01727513
18FGFR21.96986718
19TRIB31.91593754
20MET1.88267317
21MST41.86974227
22MAP3K21.81136053
23KSR21.80542224
24FES1.80100680
25WNK11.79599610
26BMPR1B1.78634010
27FGFR31.76635420
28PRPF4B1.76277539
29SGK2231.72158558
30SGK4941.72158558
31TGFBR21.67053061
32CASK1.65899464
33ZAP701.65612931
34FGFR41.64537492
35CLK11.64452664
36MAP3K31.61245805
37CSK1.57386569
38CSNK1G31.50354617
39TRPM71.45834125
40UHMK11.43848514
41JAK31.43311437
42CDK121.40820164
43MAP4K11.38170933
44MKNK11.36840529
45CSNK1A1L1.35694194
46LIMK11.34829969
47PIK3CA1.34088649
48SCYL21.33737185
49OBSCN1.32162101
50BLK1.30906724
51FER1.29940649
52CSNK1G11.28459576
53MAP3K11.27093306
54MAPK151.25486952
55BMPR21.25287054
56CAMK2D1.24996899
57CAMK2B1.24202761
58PDGFRA1.22473900
59TTN1.19915108
60ROCK21.15685205
61DMPK1.10755615
62PRKD31.10047551
63LATS11.08871473
64CDK191.08313655
65NEK91.08160614
66MAP2K31.08046257
67INSRR1.02355396
68SGK31.00573688
69MST1R0.98833409
70CDC42BPA0.98702501
71TBK10.98509369
72CSNK1G20.98294364
73HCK0.98279944
74ICK0.97265772
75MAPK130.95730950
76STK380.95244942
77CDK60.93830388
78NTRK10.92047929
79PRKCE0.91360746
80PIK3CG0.91157835
81GRK60.91034984
82TAOK30.89568367
83JAK20.88939821
84PDGFRB0.87941433
85STK240.87261482
86IKBKE0.85221490
87ZAK0.84408211
88PDPK10.83933145
89MAP3K60.83655074
90EEF2K0.83599768
91PRKCQ0.82592873
92RET0.82476152
93MAPK120.82451630
94MAP3K70.82395796
95CSF1R0.81630941
96TIE10.81627983
97CAMK2G0.80905186
98ADRBK20.77892993
99RAF10.77816151
100BTK0.77411715
101MAP3K90.77361221
102EPHA30.76706183
103PDK10.76564993
104MKNK20.75997728
105RPS6KA50.74894551
106HIPK20.74432544
107PTK20.73497810
108LRRK20.72892005
109DYRK20.71611351
110SMG10.71462608
111PRKCH0.71061939
112SIK30.69572867
113MAPK110.69285368
114STK100.69102952
115TEC0.68664098
116CAMK2A0.68012219
117EIF2AK30.67968558
118SIK10.67820597
119SYK0.65604504
120PRKD10.63869035
121PRKAA20.62747008
122TESK20.61895388
123ARAF0.61571035
124EPHA20.61107888
125MOS0.60244485
126LCK0.58293380
127PRKG20.57654053
128YES10.54972147
129KDR0.54702417
130IRAK30.54636778
131KIT0.54291016
132MTOR0.54092763
133PAK40.54068051
134CDK30.54066979
135PAK30.53535598
136PRKG10.53504212
137FGR0.52290407
138TNK20.52269824
139PTK60.51975202
140TESK10.51657440
141NLK0.50684567
142FRK0.50390780
143CSNK1A10.48728758
144NUAK10.47150633
145STK38L0.47116822
146AKT30.46887285
147STK160.45736631
148ERBB40.45420792
149MARK20.45346517
150GSK3A0.44822155
151STK30.44665630
152PRKACB0.43143854
153SGK20.41884936
154GRK70.40995003
155GRK10.40593139
156MAP3K140.39906783
157VRK10.35548869
158CSNK1D0.35451362
159TXK0.34890062
160PRKD20.32651294
161MAPK70.32187213
162PRKACA0.32160223
163IRAK10.32055585
164MYLK0.32015725
165CDK50.31704767
166SGK10.29252815
167MAPKAPK20.29084611
168MAP2K20.28662703
169MELK0.28111488
170FYN0.27957170
171ITK0.27910394
172IRAK40.27888338
173BRSK20.25912706
174PHKG20.25706761
175PHKG10.25706761
176NTRK20.24721513
177PLK20.23309418
178STK40.22660132
179IKBKB0.22053545

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.84895111
2Fatty acid elongation_Homo sapiens_hsa000624.75481236
3Steroid biosynthesis_Homo sapiens_hsa001004.50986029
4Protein export_Homo sapiens_hsa030603.98345548
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.86198691
6Ether lipid metabolism_Homo sapiens_hsa005653.40462964
7Sulfur metabolism_Homo sapiens_hsa009203.09062572
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49232772
9Sphingolipid metabolism_Homo sapiens_hsa006002.41108162
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17983672
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.13898038
12B cell receptor signaling pathway_Homo sapiens_hsa046621.63559028
13Linoleic acid metabolism_Homo sapiens_hsa005911.62652103
14Histidine metabolism_Homo sapiens_hsa003401.61034600
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60399101
16Oxidative phosphorylation_Homo sapiens_hsa001901.58812260
17Osteoclast differentiation_Homo sapiens_hsa043801.55818975
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51684630
19Leishmaniasis_Homo sapiens_hsa051401.49445799
20Acute myeloid leukemia_Homo sapiens_hsa052211.47323756
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.46270716
22Pancreatic cancer_Homo sapiens_hsa052121.44268068
23Arachidonic acid metabolism_Homo sapiens_hsa005901.37001998
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34507212
25Platelet activation_Homo sapiens_hsa046111.32180819
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.31413496
27Chronic myeloid leukemia_Homo sapiens_hsa052201.30592883
28Staphylococcus aureus infection_Homo sapiens_hsa051501.27878870
29Vitamin B6 metabolism_Homo sapiens_hsa007501.27824479
30Serotonergic synapse_Homo sapiens_hsa047261.27631320
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25199534
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24432797
33Non-small cell lung cancer_Homo sapiens_hsa052231.23690376
34Toxoplasmosis_Homo sapiens_hsa051451.23203163
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22514480
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.21433765
37Parkinsons disease_Homo sapiens_hsa050121.18691961
38T cell receptor signaling pathway_Homo sapiens_hsa046601.17787727
39Folate biosynthesis_Homo sapiens_hsa007901.17639874
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17593544
41Non-homologous end-joining_Homo sapiens_hsa034501.17286711
42Amoebiasis_Homo sapiens_hsa051461.16658039
43Thyroid cancer_Homo sapiens_hsa052161.12848417
44Focal adhesion_Homo sapiens_hsa045101.12190023
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11832613
46Alzheimers disease_Homo sapiens_hsa050101.11526160
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11103186
48Tuberculosis_Homo sapiens_hsa051521.10912486
49Hepatitis C_Homo sapiens_hsa051601.10299868
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09022611
51Adherens junction_Homo sapiens_hsa045201.08281919
52Axon guidance_Homo sapiens_hsa043601.07062803
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06849985
54TNF signaling pathway_Homo sapiens_hsa046681.05865933
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04862140
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03333002
57VEGF signaling pathway_Homo sapiens_hsa043701.03057957
58Inositol phosphate metabolism_Homo sapiens_hsa005621.03028947
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01457096
60Measles_Homo sapiens_hsa051621.01140290
61Endometrial cancer_Homo sapiens_hsa052131.01115702
62Influenza A_Homo sapiens_hsa051641.00851655
63Ovarian steroidogenesis_Homo sapiens_hsa049130.99966243
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98969340
65Insulin resistance_Homo sapiens_hsa049310.97282827
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.97169839
67Viral myocarditis_Homo sapiens_hsa054160.97094560
68Circadian rhythm_Homo sapiens_hsa047100.93913390
69Prolactin signaling pathway_Homo sapiens_hsa049170.93425195
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92264500
71Glioma_Homo sapiens_hsa052140.91514061
72mTOR signaling pathway_Homo sapiens_hsa041500.91378112
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.90563001
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89839880
75Hepatitis B_Homo sapiens_hsa051610.89824351
76Choline metabolism in cancer_Homo sapiens_hsa052310.89570909
77Basal transcription factors_Homo sapiens_hsa030220.89558330
78Long-term potentiation_Homo sapiens_hsa047200.88632245
79GnRH signaling pathway_Homo sapiens_hsa049120.87850913
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.87221098
81Rheumatoid arthritis_Homo sapiens_hsa053230.86585176
82Pertussis_Homo sapiens_hsa051330.86281881
83Chemokine signaling pathway_Homo sapiens_hsa040620.86055588
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85033635
85Proteoglycans in cancer_Homo sapiens_hsa052050.83634503
86Autoimmune thyroid disease_Homo sapiens_hsa053200.81200895
87Vibrio cholerae infection_Homo sapiens_hsa051100.80960599
88Lysosome_Homo sapiens_hsa041420.79676186
89Tight junction_Homo sapiens_hsa045300.79454545
90Arginine and proline metabolism_Homo sapiens_hsa003300.79255108
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78976524
92Insulin signaling pathway_Homo sapiens_hsa049100.78428535
93Mineral absorption_Homo sapiens_hsa049780.78409182
94Renin secretion_Homo sapiens_hsa049240.77917218
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77473050
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.74514139
97Glutamatergic synapse_Homo sapiens_hsa047240.74195346
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.73456185
99Estrogen signaling pathway_Homo sapiens_hsa049150.73386069
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72875539
101Shigellosis_Homo sapiens_hsa051310.72354659
102Small cell lung cancer_Homo sapiens_hsa052220.71471303
103ErbB signaling pathway_Homo sapiens_hsa040120.71352262
104FoxO signaling pathway_Homo sapiens_hsa040680.71053014
105Herpes simplex infection_Homo sapiens_hsa051680.70700647
106Type I diabetes mellitus_Homo sapiens_hsa049400.70457006
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69897909
108Long-term depression_Homo sapiens_hsa047300.69542715
109Glutathione metabolism_Homo sapiens_hsa004800.67448930
110Renal cell carcinoma_Homo sapiens_hsa052110.66690088
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66502876
112Fatty acid metabolism_Homo sapiens_hsa012120.66298648
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65966770
114Ras signaling pathway_Homo sapiens_hsa040140.64202367
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63320867
116Antigen processing and presentation_Homo sapiens_hsa046120.62793187
117Cocaine addiction_Homo sapiens_hsa050300.62458876
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62230386
119Renin-angiotensin system_Homo sapiens_hsa046140.61229787
120Huntingtons disease_Homo sapiens_hsa050160.60837052
121GABAergic synapse_Homo sapiens_hsa047270.60467437
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60150174
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60118276
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60043838
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59280153
126Vitamin digestion and absorption_Homo sapiens_hsa049770.58862884
127Apoptosis_Homo sapiens_hsa042100.58331302
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56507823
129Rap1 signaling pathway_Homo sapiens_hsa040150.56341702
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.56320418
131PPAR signaling pathway_Homo sapiens_hsa033200.55421971
132Salmonella infection_Homo sapiens_hsa051320.54247409
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54220135
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53937575
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51090141
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.50886781
137Butanoate metabolism_Homo sapiens_hsa006500.49626166
138Cardiac muscle contraction_Homo sapiens_hsa042600.48298557
139Pancreatic secretion_Homo sapiens_hsa049720.47809136
140Metabolic pathways_Homo sapiens_hsa011000.47327061
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47205446
142Peroxisome_Homo sapiens_hsa041460.46941592
143Malaria_Homo sapiens_hsa051440.46118293
144ECM-receptor interaction_Homo sapiens_hsa045120.44709778
145Morphine addiction_Homo sapiens_hsa050320.44544806
146Collecting duct acid secretion_Homo sapiens_hsa049660.43425862
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42401266
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41738836
149Endocytosis_Homo sapiens_hsa041440.41477542
150Phagosome_Homo sapiens_hsa041450.40601386
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.40004968
152Circadian entrainment_Homo sapiens_hsa047130.39379215
153Regulation of autophagy_Homo sapiens_hsa041400.38837225
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38540195
155Cholinergic synapse_Homo sapiens_hsa047250.38048068
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37826892
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.37628676
158Other glycan degradation_Homo sapiens_hsa005110.37168303
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36799712
160Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36321783
161Propanoate metabolism_Homo sapiens_hsa006400.34518456
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34199039
163PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33098358
164Prostate cancer_Homo sapiens_hsa052150.32695358
165Taste transduction_Homo sapiens_hsa047420.32515710
166Phospholipase D signaling pathway_Homo sapiens_hsa040720.30685388
167RNA polymerase_Homo sapiens_hsa030200.29818849
168Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28694968
169Dorso-ventral axis formation_Homo sapiens_hsa043200.28635128
170Chemical carcinogenesis_Homo sapiens_hsa052040.26931443
171Caffeine metabolism_Homo sapiens_hsa002320.26854099
172Gastric acid secretion_Homo sapiens_hsa049710.26128381
173Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25930609
174Allograft rejection_Homo sapiens_hsa053300.24251053
175Phototransduction_Homo sapiens_hsa047440.24056345
176Graft-versus-host disease_Homo sapiens_hsa053320.24046877
177Retinol metabolism_Homo sapiens_hsa008300.23885239
178Hematopoietic cell lineage_Homo sapiens_hsa046400.23534609
179Insulin secretion_Homo sapiens_hsa049110.23528154

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