EFCAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.48265034
2sarcomere organization (GO:0045214)6.47970952
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.44431867
4regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.38797057
5cardiac myofibril assembly (GO:0055003)6.26694219
6tricarboxylic acid cycle (GO:0006099)6.22192263
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.14642465
8regulation of relaxation of muscle (GO:1901077)6.10220236
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.05548401
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.88704047
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.58035895
12cardiac muscle contraction (GO:0060048)5.57075143
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.53761227
14myofibril assembly (GO:0030239)5.42276971
15regulation of cell communication by electrical coupling (GO:0010649)5.40979393
16respiratory electron transport chain (GO:0022904)5.39373461
17regulation of actin filament-based movement (GO:1903115)5.39143769
18electron transport chain (GO:0022900)5.29096098
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23826037
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.04413781
21ATP synthesis coupled proton transport (GO:0015986)4.97607513
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97607513
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.91656640
24axoneme assembly (GO:0035082)4.83449893
25cardiac muscle cell development (GO:0055013)4.74360293
26sarcoplasmic reticulum calcium ion transport (GO:0070296)4.69009166
27regulation of acyl-CoA biosynthetic process (GO:0050812)4.63458281
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.58007141
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50659081
30behavioral response to nicotine (GO:0035095)4.49704748
31ventricular cardiac muscle cell action potential (GO:0086005)4.46569780
32regulation of membrane repolarization (GO:0060306)4.46447716
33regulation of sarcomere organization (GO:0060297)4.42518533
34cardiac cell development (GO:0055006)4.39448772
35oxidative phosphorylation (GO:0006119)4.37215860
36muscle filament sliding (GO:0030049)4.33303221
37actin-myosin filament sliding (GO:0033275)4.33303221
38adult heart development (GO:0007512)4.32895600
39positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.32253884
40regulation of striated muscle contraction (GO:0006942)4.26306997
41regulation of cardiac muscle cell contraction (GO:0086004)4.26180035
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.23240622
43detection of calcium ion (GO:0005513)4.20618399
44cell communication involved in cardiac conduction (GO:0086065)4.19453874
45striated muscle contraction (GO:0006941)4.18381039
46cilium or flagellum-dependent cell motility (GO:0001539)4.17961489
47regulation of cofactor metabolic process (GO:0051193)4.15320545
48regulation of coenzyme metabolic process (GO:0051196)4.15320545
49cardiac muscle hypertrophy (GO:0003300)4.14542716
50heart contraction (GO:0060047)4.08057038
51heart process (GO:0003015)4.08057038
52regulation of cilium movement (GO:0003352)4.04676752
53oxygen transport (GO:0015671)4.03863206
54fucose catabolic process (GO:0019317)4.00651689
55L-fucose metabolic process (GO:0042354)4.00651689
56L-fucose catabolic process (GO:0042355)4.00651689
57regulation of cardiac muscle contraction (GO:0055117)4.00627277
58regulation of the force of heart contraction (GO:0002026)3.96211031
59regulation of skeletal muscle contraction (GO:0014819)3.95168954
60cell communication by electrical coupling (GO:0010644)3.93223388
61striated muscle hypertrophy (GO:0014897)3.92739319
62cardiac muscle tissue morphogenesis (GO:0055008)3.91999449
63quinone biosynthetic process (GO:1901663)3.86540195
64ubiquinone biosynthetic process (GO:0006744)3.86540195
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.86279803
66succinate metabolic process (GO:0006105)3.79977873
67heart trabecula formation (GO:0060347)3.78930727
68NADH metabolic process (GO:0006734)3.75869773
69cilium movement (GO:0003341)3.74061176
70ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.72028143
71positive regulation of cation channel activity (GO:2001259)3.71782971
72actomyosin structure organization (GO:0031032)3.70394447
73ATP biosynthetic process (GO:0006754)3.68500450
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66470076
75regulation of calcium ion transmembrane transporter activity (GO:1901019)3.65235634
76regulation of calcium ion transmembrane transport (GO:1903169)3.65235634
77response to pheromone (GO:0019236)3.63744340
78plasma membrane repair (GO:0001778)3.63155287
79indole-containing compound catabolic process (GO:0042436)3.62997024
80indolalkylamine catabolic process (GO:0046218)3.62997024
81tryptophan catabolic process (GO:0006569)3.62997024
82cilium organization (GO:0044782)3.62363950
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60563530
84indolalkylamine metabolic process (GO:0006586)3.58853376
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57483026
86carnitine shuttle (GO:0006853)3.57326659
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.57151046
88regulation of sulfur metabolic process (GO:0042762)3.56793589
89regulation of heart rate (GO:0002027)3.54318700
90cilium assembly (GO:0042384)3.52362513
91cardiac muscle cell action potential (GO:0086001)3.51579130
92inner mitochondrial membrane organization (GO:0007007)3.50699044
93purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50369007
94muscle tissue morphogenesis (GO:0060415)3.49902424
95cardiac muscle cell action potential involved in contraction (GO:0086002)3.49450398
96relaxation of cardiac muscle (GO:0055119)3.48324075
97actin-mediated cell contraction (GO:0070252)3.45844954
98epithelial cilium movement (GO:0003351)3.42972044
99protein complex biogenesis (GO:0070271)3.41066260
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40688686
101mitochondrial respiratory chain complex I assembly (GO:0032981)3.40688686
102NADH dehydrogenase complex assembly (GO:0010257)3.40688686
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38867044
104muscle hypertrophy (GO:0014896)3.37743040
105detection of light stimulus involved in sensory perception (GO:0050962)3.37411114
106detection of light stimulus involved in visual perception (GO:0050908)3.37411114
107carnitine transmembrane transport (GO:1902603)3.36683828
108kynurenine metabolic process (GO:0070189)3.34244042
109negative regulation of potassium ion transport (GO:0043267)3.33885829
110cardiac conduction (GO:0061337)3.31664623
111positive regulation of potassium ion transmembrane transport (GO:1901381)3.31346735
112aerobic respiration (GO:0009060)3.30131773
113positive regulation of heart rate (GO:0010460)3.30125680
114cilium morphogenesis (GO:0060271)3.29982005
115ubiquinone metabolic process (GO:0006743)3.29357213
116centriole replication (GO:0007099)3.27523103
117nonmotile primary cilium assembly (GO:0035058)3.26012855
118axonemal dynein complex assembly (GO:0070286)3.24762006
119regulation of heart contraction (GO:0008016)3.23072532
120neural tube formation (GO:0001841)3.22183386
121negative regulation of calcium ion transmembrane transport (GO:1903170)3.20050583
122negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.20050583
123adrenergic receptor signaling pathway (GO:0071875)3.19964428
124photoreceptor cell maintenance (GO:0045494)3.19866146
125cellular ketone body metabolic process (GO:0046950)3.18678549
126platelet dense granule organization (GO:0060155)3.18123731
127GTP biosynthetic process (GO:0006183)3.17428133
128motile cilium assembly (GO:0044458)3.17367590
129regulation of heart rate by cardiac conduction (GO:0086091)3.17244838
130mitochondrial fusion (GO:0008053)3.16288449
131tryptophan metabolic process (GO:0006568)3.12794536
132mitochondrial respiratory chain complex assembly (GO:0033108)3.12764248
133intraciliary transport (GO:0042073)3.11921874
134retinal cone cell development (GO:0046549)3.04684790
135protein localization to cilium (GO:0061512)3.04198730
136DNA deamination (GO:0045006)3.03012404
137respiratory chain complex IV assembly (GO:0008535)3.01364389
138indole-containing compound metabolic process (GO:0042430)2.98283108
139dopamine transport (GO:0015872)2.95409258
140sperm motility (GO:0030317)2.90192827
141ketone body metabolic process (GO:1902224)2.89533302
142left/right axis specification (GO:0070986)2.86856602
143neuronal action potential (GO:0019228)2.85370489
144sulfation (GO:0051923)2.84854703
145gamma-aminobutyric acid transport (GO:0015812)2.84325764
146cornea development in camera-type eye (GO:0061303)2.84103820
147cytochrome complex assembly (GO:0017004)2.83218261
148amine catabolic process (GO:0009310)2.80821165
149cellular biogenic amine catabolic process (GO:0042402)2.80821165
150cellular component assembly involved in morphogenesis (GO:0010927)2.80392124
151behavioral response to ethanol (GO:0048149)2.77650155
152serotonin metabolic process (GO:0042428)2.76332897
153piRNA metabolic process (GO:0034587)2.75633707
154preassembly of GPI anchor in ER membrane (GO:0016254)2.74228164
155replication fork processing (GO:0031297)2.73496093
156water-soluble vitamin biosynthetic process (GO:0042364)2.73150990
157reciprocal DNA recombination (GO:0035825)2.72391382
158reciprocal meiotic recombination (GO:0007131)2.72391382
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71701338
160protein polyglutamylation (GO:0018095)2.71134261
161negative regulation of telomere maintenance (GO:0032205)2.67197948
162primary amino compound metabolic process (GO:1901160)2.65246274
163regulation of microtubule-based movement (GO:0060632)2.64895236
164centriole assembly (GO:0098534)2.63046822
165benzene-containing compound metabolic process (GO:0042537)2.62783847
166reflex (GO:0060004)2.61668050
167G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61538497
168protein K11-linked deubiquitination (GO:0035871)2.60182536
169regulation of nuclear cell cycle DNA replication (GO:0033262)2.60076337
170transmission of nerve impulse (GO:0019226)2.58749745
171L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57940854
172rRNA catabolic process (GO:0016075)2.57380023
173regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54182939
174protein neddylation (GO:0045116)2.53374121
175DNA double-strand break processing (GO:0000729)2.53115383
176rhodopsin mediated signaling pathway (GO:0016056)2.51853668
177mannosylation (GO:0097502)2.51628956
178photoreceptor cell development (GO:0042461)2.51392068
179DNA methylation involved in gamete generation (GO:0043046)2.50099409
180microtubule bundle formation (GO:0001578)2.49789034
181recombinational repair (GO:0000725)2.48631362
182double-strand break repair via homologous recombination (GO:0000724)2.48115941
183regulation of action potential (GO:0098900)2.47531590
184spinal cord motor neuron differentiation (GO:0021522)2.47270555
185regulation of glucokinase activity (GO:0033131)2.44431083
186regulation of hexokinase activity (GO:1903299)2.44431083
187signal peptide processing (GO:0006465)2.44019735
188drug catabolic process (GO:0042737)2.42066511
189nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41235541
190negative regulation of mast cell activation (GO:0033004)2.39552344
191male meiosis I (GO:0007141)2.38461599
192synaptic transmission, cholinergic (GO:0007271)2.36675535
193phosphatidylinositol acyl-chain remodeling (GO:0036149)2.35153490
194exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.34165656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.97075219
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.63638987
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91676696
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.90855054
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38892984
6IGF1R_20145208_ChIP-Seq_DFB_Human2.33297626
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28527266
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20421926
9* EWS_26573619_Chip-Seq_HEK293_Human2.20236256
10TAF15_26573619_Chip-Seq_HEK293_Human2.04285193
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02993997
12* ZNF274_21170338_ChIP-Seq_K562_Hela1.99192896
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96223996
14SALL1_21062744_ChIP-ChIP_HESCs_Human1.94370092
15GBX2_23144817_ChIP-Seq_PC3_Human1.93035286
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91894309
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86377512
18TBX20_22080862_ChIP-Seq_HEART_Mouse1.83089622
19TBX20_22328084_ChIP-Seq_HEART_Mouse1.83089622
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81475015
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81200360
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80146526
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79854268
24VDR_22108803_ChIP-Seq_LS180_Human1.76180435
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74811790
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74429978
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73214124
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73087932
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.70360854
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70343521
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.67752832
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64719728
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.57598576
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56595591
35STAT3_23295773_ChIP-Seq_U87_Human1.55362409
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54657831
37SMAD4_21799915_ChIP-Seq_A2780_Human1.53881146
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51951373
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51083716
40REST_21632747_ChIP-Seq_MESCs_Mouse1.49949875
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48934790
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46855451
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46158220
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45448832
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44446655
46TP53_22573176_ChIP-Seq_HFKS_Human1.43457401
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.42329814
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42040471
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42040471
50BCAT_22108803_ChIP-Seq_LS180_Human1.41183286
51NANOG_19829295_ChIP-Seq_ESCs_Human1.41163001
52SOX2_19829295_ChIP-Seq_ESCs_Human1.41163001
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.40681842
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40681842
55IRF1_19129219_ChIP-ChIP_H3396_Human1.40172133
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.39570871
57DROSHA_22980978_ChIP-Seq_HELA_Human1.39536841
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38834788
59MYC_18940864_ChIP-ChIP_HL60_Human1.38604181
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36061054
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35069223
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.34940784
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34578852
64TCF4_22108803_ChIP-Seq_LS180_Human1.31602300
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.29264154
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27672599
67ER_23166858_ChIP-Seq_MCF-7_Human1.26158481
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25454368
69RUNX2_22187159_ChIP-Seq_PCA_Human1.25293742
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.23564180
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22850093
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21626615
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20973749
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20085331
75AR_20517297_ChIP-Seq_VCAP_Human1.19976194
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19096181
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17950708
78* GATA3_21878914_ChIP-Seq_MCF-7_Human1.16203224
79NCOR_22424771_ChIP-Seq_293T_Human1.15893234
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15532093
81RNF2_27304074_Chip-Seq_NSC_Mouse1.14516815
82* CRX_20693478_ChIP-Seq_RETINA_Mouse1.13953071
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13325119
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13301555
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13071095
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11973445
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.11282559
88* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09915667
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09846650
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09824894
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09787547
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09293542
93* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07861263
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.07612917
95CDX2_22108803_ChIP-Seq_LS180_Human1.07520431
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07251059
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06798879
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.06339555
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06188673
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05576246
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05574864
102* P53_22387025_ChIP-Seq_ESCs_Mouse1.05411344
103P300_19829295_ChIP-Seq_ESCs_Human1.05040850
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04530619
105HOXB7_26014856_ChIP-Seq_BT474_Human1.03027084
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02116719
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.01497665
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.00651530
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00411401
110* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00220471
111* ETV1_20927104_ChIP-Seq_GIST48_Human0.98607140
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98604944
113CBP_20019798_ChIP-Seq_JUKART_Human0.98604944
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.98434071
115* STAT3_18555785_Chip-Seq_ESCs_Mouse0.98370248
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98143698
117GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98004908
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97934150
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97919764
120* E2F1_18555785_Chip-Seq_ESCs_Mouse0.97635924
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97202013
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.96549139
123AR_21572438_ChIP-Seq_LNCaP_Human0.96399558
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.95333285
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95307501
126WDR5_24793694_ChIP-Seq_LNCAP_Human0.95270470
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94661833
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.94318201
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93790743
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93766083
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93355311
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92635913
133TCF4_23295773_ChIP-Seq_U87_Human0.92256563
134* NFE2_27457419_Chip-Seq_LIVER_Mouse0.91897570
135ERG_20517297_ChIP-Seq_VCAP_Human0.90733846
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.88332587
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88173718
138CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87379222
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86681245
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.86545036
141* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86257692
142ZNF263_19887448_ChIP-Seq_K562_Human0.86217533
143* EZH2_27294783_Chip-Seq_NPCs_Mouse0.85193602
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.84959440
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84739227
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84730009
147FUS_26573619_Chip-Seq_HEK293_Human0.84555427
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84032393
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84002910
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83206875
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83206875
152* TBL1_22424771_ChIP-Seq_293T_Human0.83104250
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81795590
154AR_25329375_ChIP-Seq_VCAP_Human0.81708384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.12918287
2MP0002837_dystrophic_cardiac_calcinosis6.00987591
3MP0000751_myopathy4.84894382
4MP0004084_abnormal_cardiac_muscle4.67913392
5MP0004215_abnormal_myocardial_fiber4.67804231
6MP0000749_muscle_degeneration3.70180377
7MP0004036_abnormal_muscle_relaxation3.62895755
8MP0005330_cardiomyopathy3.37286613
9MP0003195_calcinosis2.86004669
10MP0003137_abnormal_impulse_conducting2.77456768
11MP0002653_abnormal_ependyma_morphology2.66679460
12MP0004484_altered_response_of2.64459575
13MP0004145_abnormal_muscle_electrophysio2.60251404
14MP0002972_abnormal_cardiac_muscle2.56066098
15MP0008775_abnormal_heart_ventricle2.50721289
16MP0005551_abnormal_eye_electrophysiolog2.48476682
17MP0004510_myositis2.39486016
18MP0004087_abnormal_muscle_fiber2.31913483
19MP0004130_abnormal_muscle_cell2.26846580
20MP0002102_abnormal_ear_morphology2.26040789
21MP0006036_abnormal_mitochondrial_physio2.21058049
22MP0008875_abnormal_xenobiotic_pharmacok2.17341674
23MP0005620_abnormal_muscle_contractility2.16750371
24MP0002106_abnormal_muscle_physiology2.15487976
25MP0004085_abnormal_heartbeat2.09532276
26MP0001544_abnormal_cardiovascular_syste2.02696045
27MP0005385_cardiovascular_system_phenoty2.02696045
28MP0000569_abnormal_digit_pigmentation1.99070533
29MP0005253_abnormal_eye_physiology1.95403038
30MP0006138_congestive_heart_failure1.91276324
31MP0000372_irregular_coat_pigmentation1.90068791
32MP0000750_abnormal_muscle_regeneration1.86000441
33MP0002269_muscular_atrophy1.81865117
34MP0004133_heterotaxia1.80390469
35MP0010630_abnormal_cardiac_muscle1.77713721
36MP0008872_abnormal_physiological_respon1.76699146
37MP0005369_muscle_phenotype1.75799421
38MP0001485_abnormal_pinna_reflex1.75668623
39MP0000747_muscle_weakness1.74414208
40MP0005410_abnormal_fertilization1.73233980
41MP0002876_abnormal_thyroid_physiology1.69403925
42MP0005174_abnormal_tail_pigmentation1.66337108
43MP0003880_abnormal_central_pattern1.64846654
44MP0005645_abnormal_hypothalamus_physiol1.62652226
45MP0003828_pulmonary_edema1.61549332
46MP0005084_abnormal_gallbladder_morpholo1.58539438
47MP0000759_abnormal_skeletal_muscle1.54308546
48MP0003011_delayed_dark_adaptation1.53489471
49MP0000631_abnormal_neuroendocrine_gland1.47754652
50MP0003718_maternal_effect1.46684979
51MP0002822_catalepsy1.46584380
52MP0003787_abnormal_imprinting1.44919560
53MP0001986_abnormal_taste_sensitivity1.42000080
54MP0002938_white_spotting1.39205190
55MP0006035_abnormal_mitochondrial_morpho1.38966845
56MP0009046_muscle_twitch1.37817102
57MP0004885_abnormal_endolymph1.37077129
58MP0002127_abnormal_cardiovascular_syste1.30980490
59MP0002332_abnormal_exercise_endurance1.30672853
60MP0002928_abnormal_bile_duct1.30352266
61MP0000383_abnormal_hair_follicle1.29459294
62MP0004233_abnormal_muscle_weight1.29119314
63MP0002234_abnormal_pharynx_morphology1.26914650
64MP0000427_abnormal_hair_cycle1.26621902
65MP0002160_abnormal_reproductive_system1.25223225
66MP0003221_abnormal_cardiomyocyte_apopto1.25167093
67MP0001529_abnormal_vocalization1.23246359
68MP0010386_abnormal_urinary_bladder1.21747739
69MP0002909_abnormal_adrenal_gland1.21082963
70MP0008995_early_reproductive_senescence1.19192394
71MP0002733_abnormal_thermal_nociception1.18156615
72MP0005083_abnormal_biliary_tract1.15029059
73MP0005165_increased_susceptibility_to1.14187452
74MP0006276_abnormal_autonomic_nervous1.12973825
75MP0005171_absent_coat_pigmentation1.11249450
76MP0009745_abnormal_behavioral_response1.10545844
77MP0002272_abnormal_nervous_system1.10084291
78MP0008058_abnormal_DNA_repair1.10031153
79MP0004043_abnormal_pH_regulation1.08322987
80MP0006292_abnormal_olfactory_placode1.08266404
81MP0004147_increased_porphyrin_level1.07313285
82MP0005670_abnormal_white_adipose1.06742290
83MP0003252_abnormal_bile_duct1.06565444
84MP0003635_abnormal_synaptic_transmissio1.05950894
85MP0002064_seizures1.04196157
86MP0004859_abnormal_synaptic_plasticity1.03488552
87MP0005386_behavior/neurological_phenoty1.02906669
88MP0004924_abnormal_behavior1.02906669
89MP0005389_reproductive_system_phenotype1.02466177
90MP0004142_abnormal_muscle_tone1.02447995
91MP0004742_abnormal_vestibular_system1.01491440
92MP0003136_yellow_coat_color1.00056591
93MP0005195_abnormal_posterior_eye0.97051325
94MP0005167_abnormal_blood-brain_barrier0.96819681
95MP0002095_abnormal_skin_pigmentation0.95868475
96MP0005332_abnormal_amino_acid0.95564018
97MP0002067_abnormal_sensory_capabilities0.93273430
98MP0002277_abnormal_respiratory_mucosa0.92287465
99MP0009697_abnormal_copulation0.89593714
100MP0008789_abnormal_olfactory_epithelium0.89147605
101MP0002638_abnormal_pupillary_reflex0.88478391
102MP0008569_lethality_at_weaning0.85905184
103MP0003878_abnormal_ear_physiology0.85634396
104MP0005377_hearing/vestibular/ear_phenot0.85634396
105MP0005075_abnormal_melanosome_morpholog0.84962039
106MP0000230_abnormal_systemic_arterial0.84660382
107MP0001963_abnormal_hearing_physiology0.82919799
108MP0002572_abnormal_emotion/affect_behav0.82885088
109MP0002229_neurodegeneration0.82813606
110MP0000026_abnormal_inner_ear0.82176581
111MP0002752_abnormal_somatic_nervous0.82046692
112MP0001324_abnormal_eye_pigmentation0.81627275
113MP0001486_abnormal_startle_reflex0.81007983
114MP0001440_abnormal_grooming_behavior0.80800094
115MP0002751_abnormal_autonomic_nervous0.79336163
116MP0005666_abnormal_adipose_tissue0.79226599
117MP0001501_abnormal_sleep_pattern0.79001125
118MP0002210_abnormal_sex_determination0.78622947
119MP0001764_abnormal_homeostasis0.78183354
120MP0005085_abnormal_gallbladder_physiolo0.78075831
121MP0005379_endocrine/exocrine_gland_phen0.76189220
122MP0005535_abnormal_body_temperature0.75721691
123MP0002735_abnormal_chemical_nociception0.75128782
124MP0003698_abnormal_male_reproductive0.73378788
125MP0000653_abnormal_sex_gland0.73297240
126MP0002163_abnormal_gland_morphology0.72702988
127MP0001968_abnormal_touch/_nociception0.71903698
128MP0005266_abnormal_metabolism0.71781765
129MP0001984_abnormal_olfaction0.71086432
130MP0002108_abnormal_muscle_morphology0.70489651
131MP0001905_abnormal_dopamine_level0.69573805
132MP0005409_darkened_coat_color0.67756008
133MP0000266_abnormal_heart_morphology0.66782184
134MP0002063_abnormal_learning/memory/cond0.65953061
135MP0003950_abnormal_plasma_membrane0.65906290
136MP0000343_altered_response_to0.65338209
137MP0006072_abnormal_retinal_apoptosis0.64732091
138MP0002557_abnormal_social/conspecific_i0.64503871
139MP0001188_hyperpigmentation0.62067097
140MP0004270_analgesia0.61693170
141MP0002734_abnormal_mechanical_nocicepti0.61355111
142MP0005187_abnormal_penis_morphology0.59365724
143MP0005623_abnormal_meninges_morphology0.57409617
144MP0005646_abnormal_pituitary_gland0.55908973
145MP0009379_abnormal_foot_pigmentation0.55481570
146MP0001970_abnormal_pain_threshold0.54490415
147MP0005423_abnormal_somatic_nervous0.51962563
148MP0003633_abnormal_nervous_system0.51910565
149MP0003567_abnormal_fetal_cardiomyocyte0.51148021
150MP0002066_abnormal_motor_capabilities/c0.50964066
151MP0002078_abnormal_glucose_homeostasis0.50576602
152MP0002736_abnormal_nociception_after0.50463869
153MP0008877_abnormal_DNA_methylation0.49845965
154MP0001929_abnormal_gametogenesis0.48560943
155MP0010368_abnormal_lymphatic_system0.47883145
156MP0003279_aneurysm0.47837848

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.27248113
2Calf muscle hypertrophy (HP:0008981)5.70865958
3Atrial fibrillation (HP:0005110)5.45067893
4Muscle hypertrophy of the lower extremities (HP:0008968)5.31501937
5Ventricular tachycardia (HP:0004756)5.31098871
6Primary atrial arrhythmia (HP:0001692)5.14390795
7Supraventricular tachycardia (HP:0004755)5.03475057
8Supraventricular arrhythmia (HP:0005115)4.88298524
9Exercise-induced myalgia (HP:0003738)4.84520194
10Pancreatic cysts (HP:0001737)4.71638987
11Abnormality of the calf musculature (HP:0001430)4.64676468
12Acute necrotizing encephalopathy (HP:0006965)4.62284471
13Pancreatic fibrosis (HP:0100732)4.54068492
14Abnormal mitochondria in muscle tissue (HP:0008316)4.48904445
15True hermaphroditism (HP:0010459)4.36008999
16Abnormality of midbrain morphology (HP:0002418)4.33818336
17Molar tooth sign on MRI (HP:0002419)4.33818336
18Syncope (HP:0001279)4.25538445
19Hepatic necrosis (HP:0002605)4.22486004
20Hepatocellular necrosis (HP:0001404)4.16729017
21Lipoatrophy (HP:0100578)4.12666523
22Myoglobinuria (HP:0002913)4.10009500
23Mitochondrial inheritance (HP:0001427)4.06108692
24Bundle branch block (HP:0011710)4.00752348
25Palpitations (HP:0001962)3.98053163
26Nephronophthisis (HP:0000090)3.93513106
27Progressive macrocephaly (HP:0004481)3.91145970
28Exercise-induced muscle cramps (HP:0003710)3.88408580
29Acute encephalopathy (HP:0006846)3.75936660
30Prolonged QT interval (HP:0001657)3.71797337
31Abnormal ciliary motility (HP:0012262)3.67533986
32Increased CSF lactate (HP:0002490)3.66699148
33Dilated cardiomyopathy (HP:0001644)3.66192171
34Absent/shortened dynein arms (HP:0200106)3.61100719
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.61100719
36Abnormal respiratory motile cilium physiology (HP:0012261)3.58251571
37Muscle fiber splitting (HP:0003555)3.48224067
38Congenital stationary night blindness (HP:0007642)3.42865147
39Abnormality of the renal medulla (HP:0100957)3.41161705
40Heart block (HP:0012722)3.39333201
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36662930
42Left ventricular hypertrophy (HP:0001712)3.33696253
43Medial flaring of the eyebrow (HP:0010747)3.29048164
44Increased intramyocellular lipid droplets (HP:0012240)3.27273830
45Cerebral edema (HP:0002181)3.25916273
46Increased muscle lipid content (HP:0009058)3.24361953
47Hyporeflexia of lower limbs (HP:0002600)3.22828792
48Abnormality of the left ventricular outflow tract (HP:0011103)3.22780261
49Subaortic stenosis (HP:0001682)3.22780261
50Right ventricular cardiomyopathy (HP:0011663)3.22677239
51Cystic liver disease (HP:0006706)3.18796479
52Abnormality of the renal cortex (HP:0011035)3.15099323
53Atrioventricular block (HP:0001678)3.14836463
54Ventricular arrhythmia (HP:0004308)3.13996385
55Abnormal respiratory epithelium morphology (HP:0012253)3.11328937
56Abnormal respiratory motile cilium morphology (HP:0005938)3.11328937
57Abnormal atrioventricular conduction (HP:0005150)3.09706793
58Lipid accumulation in hepatocytes (HP:0006561)3.08347777
59Chronic hepatic failure (HP:0100626)3.07928825
60Rhabdomyolysis (HP:0003201)3.06257829
61Exercise intolerance (HP:0003546)3.04470727
62Ventricular fibrillation (HP:0001663)3.01681185
63Increased hepatocellular lipid droplets (HP:0006565)2.98443018
64Lactic acidosis (HP:0003128)2.97473968
65Asymmetric septal hypertrophy (HP:0001670)2.95813480
66Attenuation of retinal blood vessels (HP:0007843)2.94777842
67Rhinitis (HP:0012384)2.89154771
68Abolished electroretinogram (ERG) (HP:0000550)2.87937632
69EMG: myopathic abnormalities (HP:0003458)2.84641536
70Tubular atrophy (HP:0000092)2.84212617
71Abnormal EKG (HP:0003115)2.83511573
72Myotonia (HP:0002486)2.82396991
73Optic disc pallor (HP:0000543)2.73074032
74Respiratory failure (HP:0002878)2.70879533
75Decreased central vision (HP:0007663)2.68982236
76Gait imbalance (HP:0002141)2.63257333
77Congenital primary aphakia (HP:0007707)2.58986744
78Ketoacidosis (HP:0001993)2.55392623
79Pheochromocytoma (HP:0002666)2.53410423
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52815894
81Dicarboxylic aciduria (HP:0003215)2.52815894
82Gaze-evoked nystagmus (HP:0000640)2.50124443
83Bronchiectasis (HP:0002110)2.49989373
84Type II lissencephaly (HP:0007260)2.49106228
85Neuroendocrine neoplasm (HP:0100634)2.47911184
86Congenital hepatic fibrosis (HP:0002612)2.47239152
87Sclerocornea (HP:0000647)2.46929925
88Polydipsia (HP:0001959)2.46025956
89Abnormal drinking behavior (HP:0030082)2.46025956
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.44404739
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44331934
92Hyperventilation (HP:0002883)2.42515001
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41452569
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41452569
95Abnormal rod and cone electroretinograms (HP:0008323)2.41084614
96Focal motor seizures (HP:0011153)2.39593777
97Ragged-red muscle fibers (HP:0003200)2.38832993
98Male pseudohermaphroditism (HP:0000037)2.36163240
99Postaxial foot polydactyly (HP:0001830)2.34486290
100Large for gestational age (HP:0001520)2.33804772
101Pendular nystagmus (HP:0012043)2.32418811
102Furrowed tongue (HP:0000221)2.31803825
103Anencephaly (HP:0002323)2.31280536
104Chronic bronchitis (HP:0004469)2.31161682
105Genetic anticipation (HP:0003743)2.29927953
106Bile duct proliferation (HP:0001408)2.29416195
107Abnormal biliary tract physiology (HP:0012439)2.29416195
108Nephrogenic diabetes insipidus (HP:0009806)2.28275015
109Bony spicule pigmentary retinopathy (HP:0007737)2.23886355
110Increased serum lactate (HP:0002151)2.22918587
111Occipital encephalocele (HP:0002085)2.21250175
112Limb-girdle muscle atrophy (HP:0003797)2.20815715
113Hypoglycemic coma (HP:0001325)2.20798691
114Esophageal neoplasm (HP:0100751)2.20329469
115Neoplasm of head and neck (HP:0012288)2.20329469
116Genital tract atresia (HP:0001827)2.18384676
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17419089
118Abnormality of alanine metabolism (HP:0010916)2.17419089
119Hyperalaninemia (HP:0003348)2.17419089
120Renal Fanconi syndrome (HP:0001994)2.14421662
121Progressive cerebellar ataxia (HP:0002073)2.13617288
122Chronic sinusitis (HP:0011109)2.12532549
123Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12509161
124Aplasia/Hypoplasia of the tibia (HP:0005772)2.10932524
125Vaginal atresia (HP:0000148)2.09207925
126Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09123467
127Congenital, generalized hypertrichosis (HP:0004540)2.08491954
128Abnormality of fatty-acid metabolism (HP:0004359)2.07873453
129Difficulty running (HP:0009046)2.06075325
130Increased serum pyruvate (HP:0003542)2.05408012
131Abnormality of glycolysis (HP:0004366)2.05408012
132Areflexia of lower limbs (HP:0002522)2.04783219
133Central scotoma (HP:0000603)2.02021603
134Renal cortical cysts (HP:0000803)2.00711625
135Inability to walk (HP:0002540)1.99549428
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98356229
137Leukodystrophy (HP:0002415)1.97358838
138Polyuria (HP:0000103)1.96541318
139Muscle stiffness (HP:0003552)1.96305497
140Cerebellar dysplasia (HP:0007033)1.95043770
141Keratoconus (HP:0000563)1.93957159
142Increased corneal curvature (HP:0100692)1.93957159
143Increased variability in muscle fiber diameter (HP:0003557)1.93899090
144Ketosis (HP:0001946)1.93331214
145Decreased circulating renin level (HP:0003351)1.93162053
146Postaxial hand polydactyly (HP:0001162)1.91903006
147Rimmed vacuoles (HP:0003805)1.91631530
1483-Methylglutaconic aciduria (HP:0003535)1.90281063
149Palmoplantar keratoderma (HP:0000982)1.87824760
150Testicular atrophy (HP:0000029)1.87569065
151Respiratory difficulties (HP:0002880)1.87396449
152Generalized aminoaciduria (HP:0002909)1.86636129
153Poor coordination (HP:0002370)1.86480878
154Broad-based gait (HP:0002136)1.86141602
155Methylmalonic acidemia (HP:0002912)1.84601738
156Febrile seizures (HP:0002373)1.82544529
157Increased connective tissue (HP:0009025)1.81409470
158Retinitis pigmentosa (HP:0000510)1.78269791
159Hypoplastic left heart (HP:0004383)1.78079128
160Clumsiness (HP:0002312)1.77990219
161Oculomotor apraxia (HP:0000657)1.75563610
162Hypothermia (HP:0002045)1.75468606
163Difficulty climbing stairs (HP:0003551)1.75434772
164Chronic otitis media (HP:0000389)1.75333571
165Progressive external ophthalmoplegia (HP:0000590)1.75122638
166Abnormality of the pons (HP:0007361)1.74528329
167Progressive inability to walk (HP:0002505)1.73459239
168Preaxial hand polydactyly (HP:0001177)1.71394193
169Stomach cancer (HP:0012126)1.71007783
170Aplasia/Hypoplasia of the spleen (HP:0010451)1.70280416
171Chorioretinal atrophy (HP:0000533)1.69610163
172Tubulointerstitial nephritis (HP:0001970)1.69565321
173Hyperglycinuria (HP:0003108)1.68901605
174Hypoplasia of the pons (HP:0012110)1.67727823
175Intestinal atresia (HP:0011100)1.65187676
176Aplasia/Hypoplasia of the uvula (HP:0010293)1.64681764
177Optic nerve hypoplasia (HP:0000609)1.64463288
178Protruding tongue (HP:0010808)1.63614400
179Constricted visual fields (HP:0001133)1.63578040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.24143490
2PDK34.98097685
3PDK44.98097685
4MUSK3.67301801
5LMTK23.64055442
6TTN3.59411049
7PHKG23.56343373
8PHKG13.56343373
9MYLK3.30032958
10ADRBK23.15925980
11BMPR1B3.09550700
12PDK23.07013645
13OBSCN2.98638961
14MAP4K22.84599752
15TNIK2.60647146
16PINK12.48411897
17GRK72.47121093
18ACVR1B2.44046645
19GRK12.39811368
20TAOK32.27889835
21WNK32.20778302
22NUAK12.17216329
23BCKDK2.15595524
24TIE11.82828574
25MST41.73528092
26WNK41.71882184
27CASK1.57856944
28STK241.54536613
29NEK11.47684075
30PRKD31.46617893
31CAMK2D1.41085567
32MAP3K121.35704187
33DMPK1.35014405
34PIK3CA1.32958610
35CCNB11.31729441
36BRSK21.27860463
37OXSR11.26993456
38MAP2K71.25243574
39STK38L1.19132383
40TRIM281.16728704
41VRK11.15945778
42CAMK2A1.14540754
43DAPK21.12068569
44MAPKAPK31.11583376
45PAK31.11428930
46STK391.09280110
47PLK41.08456273
48CAMK11.08432317
49PLK21.06820980
50INSRR1.06405013
51NTRK31.04040712
52MAP3K40.98860745
53MAPK130.98672454
54WEE10.96991371
55PKN20.93175619
56MKNK10.92917624
57CAMKK20.90892066
58DYRK20.89601626
59WNK10.89302624
60CAMK40.88465716
61MKNK20.88024570
62NME10.83148356
63EPHA40.81470108
64TXK0.81221002
65TEC0.80994925
66TLK10.79159418
67MAPK120.79073981
68NME20.78920020
69STK380.78504184
70PTK2B0.76649020
71PRKD10.76504664
72MAP2K40.75404622
73UHMK10.73989982
74BCR0.71715568
75ERBB30.71675875
76TGFBR10.71429108
77CSNK1G20.69396826
78CAMK2G0.69248766
79PIK3CG0.68574012
80MAPKAPK50.67559054
81PKN10.67483082
82PLK30.66611426
83NEK20.65397917
84PRKAA10.64949915
85ILK0.64093488
86STK30.63673970
87MAPK150.63335521
88PRKACA0.63228590
89CSNK1G10.62368003
90MAP2K60.60589395
91PRKAA20.59898066
92ROCK10.58716203
93CAMK2B0.58156642
94CDC42BPA0.53624481
95NEK90.53364819
96PRKCE0.52595493
97IKBKB0.52428468
98VRK20.52197779
99KIT0.50761150
100PRKCQ0.50552956
101PRKACB0.50317669
102PDK10.50224055
103CSNK1G30.49714418
104GRK50.49061678
105RPS6KA50.49002896
106TNK20.48725403
107EIF2AK30.47877052
108PLK10.47629658
109PNCK0.46773839
110NLK0.46639000
111MAP3K50.46186938
112ERBB20.45198531
113MAP3K110.44602041
114CSNK1A1L0.43904049
115PRKACG0.43903498
116MARK10.43899711
117ROCK20.42231558
118DAPK30.42195515
119SGK20.42017753
120NTRK20.40994039
121RPS6KL10.40633127
122RPS6KC10.40633127
123STK110.39681217
124PDPK10.38474305
125PRKG20.38012530
126IRAK10.37811264
127FER0.37697407
128SGK10.37314898
129PRKG10.37138874
130CDK190.35232524
131PRKCA0.34187029
132RPS6KA60.34186111
133CDK30.33329820
134STK160.32686911
135CSNK1A10.32470381
136MAP3K10.32406047
137ADRBK10.31912476
138CSNK1D0.31769458
139CAMKK10.30287943
140SGK2230.29421120
141SGK4940.29421120
142ZAK0.28649328
143ARAF0.27467100
144FES0.27280263
145AKT30.27078220
146ATR0.26299603
147PRKCG0.25446741
148MAP3K70.25313974
149FLT30.23588202
150MAPK40.23486405
151PRKCH0.22750116

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.20944068
2Oxidative phosphorylation_Homo sapiens_hsa001904.56903401
3Cardiac muscle contraction_Homo sapiens_hsa042604.35489174
4Parkinsons disease_Homo sapiens_hsa050124.34274609
5Propanoate metabolism_Homo sapiens_hsa006403.40548692
6Alzheimers disease_Homo sapiens_hsa050103.24794788
7Huntingtons disease_Homo sapiens_hsa050163.21605197
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.78032671
9Dilated cardiomyopathy_Homo sapiens_hsa054142.72577773
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.63699290
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.55635823
12Linoleic acid metabolism_Homo sapiens_hsa005912.54562679
13Nitrogen metabolism_Homo sapiens_hsa009102.40390773
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32990194
15Fatty acid degradation_Homo sapiens_hsa000712.25731249
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23749368
17Pyruvate metabolism_Homo sapiens_hsa006202.12800930
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08003911
19Homologous recombination_Homo sapiens_hsa034402.07033905
20Carbon metabolism_Homo sapiens_hsa012001.98247736
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92009983
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85211014
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.83952105
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83126156
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79071376
26Fanconi anemia pathway_Homo sapiens_hsa034601.74154541
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73784262
28Fatty acid metabolism_Homo sapiens_hsa012121.69585060
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66684492
30Butanoate metabolism_Homo sapiens_hsa006501.64382589
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59532355
32Chemical carcinogenesis_Homo sapiens_hsa052041.59073436
33RNA polymerase_Homo sapiens_hsa030201.56992684
34Ether lipid metabolism_Homo sapiens_hsa005651.56846254
35Fatty acid elongation_Homo sapiens_hsa000621.55279744
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48141299
37Selenocompound metabolism_Homo sapiens_hsa004501.47567510
38Basal transcription factors_Homo sapiens_hsa030221.42596180
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39885366
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.34494871
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33707455
42Retinol metabolism_Homo sapiens_hsa008301.29653212
43Arachidonic acid metabolism_Homo sapiens_hsa005901.28769156
44Calcium signaling pathway_Homo sapiens_hsa040201.27222510
45Caffeine metabolism_Homo sapiens_hsa002321.26857750
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23481971
47ABC transporters_Homo sapiens_hsa020101.18248327
48Histidine metabolism_Homo sapiens_hsa003401.16491018
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10574599
50RNA degradation_Homo sapiens_hsa030181.10537876
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.09409206
52One carbon pool by folate_Homo sapiens_hsa006701.09030153
53Glucagon signaling pathway_Homo sapiens_hsa049221.08605993
54Circadian entrainment_Homo sapiens_hsa047131.07942885
55Olfactory transduction_Homo sapiens_hsa047401.07120106
56Nicotine addiction_Homo sapiens_hsa050331.06631099
57Taste transduction_Homo sapiens_hsa047421.01993940
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98556491
59Insulin secretion_Homo sapiens_hsa049110.97753327
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.92772613
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91797565
62Morphine addiction_Homo sapiens_hsa050320.90124864
63Renin secretion_Homo sapiens_hsa049240.88223127
64GABAergic synapse_Homo sapiens_hsa047270.86081027
65Gastric acid secretion_Homo sapiens_hsa049710.85244374
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83541997
67Non-homologous end-joining_Homo sapiens_hsa034500.80055111
68Oxytocin signaling pathway_Homo sapiens_hsa049210.79713564
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78736640
70Amphetamine addiction_Homo sapiens_hsa050310.78668281
71Glycerolipid metabolism_Homo sapiens_hsa005610.77877941
72Asthma_Homo sapiens_hsa053100.76724657
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75654115
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74762296
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74422207
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70663525
77Glutamatergic synapse_Homo sapiens_hsa047240.69676355
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69659945
79Glutathione metabolism_Homo sapiens_hsa004800.69170906
80Long-term potentiation_Homo sapiens_hsa047200.67782116
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65113271
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64994804
83beta-Alanine metabolism_Homo sapiens_hsa004100.64848061
84cAMP signaling pathway_Homo sapiens_hsa040240.64713703
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.61080132
86Ribosome_Homo sapiens_hsa030100.58847181
87Proteasome_Homo sapiens_hsa030500.57424738
88Dopaminergic synapse_Homo sapiens_hsa047280.57100336
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.56968551
90Viral myocarditis_Homo sapiens_hsa054160.56606633
91PPAR signaling pathway_Homo sapiens_hsa033200.56434073
92Serotonergic synapse_Homo sapiens_hsa047260.55654004
93Cholinergic synapse_Homo sapiens_hsa047250.55566843
94Biosynthesis of amino acids_Homo sapiens_hsa012300.54619304
95Salivary secretion_Homo sapiens_hsa049700.54204825
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53674385
97Insulin signaling pathway_Homo sapiens_hsa049100.53151465
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52457641
99Steroid biosynthesis_Homo sapiens_hsa001000.51329712
100Metabolic pathways_Homo sapiens_hsa011000.51177587
101Fat digestion and absorption_Homo sapiens_hsa049750.50689204
102Synaptic vesicle cycle_Homo sapiens_hsa047210.50352616
103Circadian rhythm_Homo sapiens_hsa047100.50198807
104Collecting duct acid secretion_Homo sapiens_hsa049660.49237901
105Starch and sucrose metabolism_Homo sapiens_hsa005000.48783740
106Pyrimidine metabolism_Homo sapiens_hsa002400.46711347
107Tryptophan metabolism_Homo sapiens_hsa003800.45782370
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45736074
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43669168
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43503484
111Purine metabolism_Homo sapiens_hsa002300.43069086
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41691801
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41486806
114Fatty acid biosynthesis_Homo sapiens_hsa000610.41486421
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.40803426
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40156949
117Mismatch repair_Homo sapiens_hsa034300.39629683
118Peroxisome_Homo sapiens_hsa041460.38051364
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37677251
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37129940
121Insulin resistance_Homo sapiens_hsa049310.36165804
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35313192
123Type I diabetes mellitus_Homo sapiens_hsa049400.35166691
124Vitamin digestion and absorption_Homo sapiens_hsa049770.34500809
125Arginine and proline metabolism_Homo sapiens_hsa003300.33195902
126Phenylalanine metabolism_Homo sapiens_hsa003600.31862200
127Nucleotide excision repair_Homo sapiens_hsa034200.29381229
128Type II diabetes mellitus_Homo sapiens_hsa049300.27601077
129HIF-1 signaling pathway_Homo sapiens_hsa040660.26940688
130Arginine biosynthesis_Homo sapiens_hsa002200.26400140
131Cocaine addiction_Homo sapiens_hsa050300.25727551
132Fructose and mannose metabolism_Homo sapiens_hsa000510.25550548
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.24584234
134Pancreatic secretion_Homo sapiens_hsa049720.23775102
135AMPK signaling pathway_Homo sapiens_hsa041520.23039472
136Dorso-ventral axis formation_Homo sapiens_hsa043200.21728799
137Protein export_Homo sapiens_hsa030600.21156358
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20057512
139Sulfur metabolism_Homo sapiens_hsa009200.19384674
140Galactose metabolism_Homo sapiens_hsa000520.17298289
141GnRH signaling pathway_Homo sapiens_hsa049120.16852238
142Gap junction_Homo sapiens_hsa045400.16663933
143Ovarian steroidogenesis_Homo sapiens_hsa049130.15381769
144Phototransduction_Homo sapiens_hsa047440.13578235
145Regulation of autophagy_Homo sapiens_hsa041400.13556348
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13080989
147Melanogenesis_Homo sapiens_hsa049160.11434249
148Tyrosine metabolism_Homo sapiens_hsa003500.08825762

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