EFCAB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.76150658
2plasma membrane fusion (GO:0045026)9.59217399
3cell-cell recognition (GO:0009988)9.45193844
4piRNA metabolic process (GO:0034587)9.17999733
5motile cilium assembly (GO:0044458)9.16388255
6reproduction (GO:0000003)8.98241982
7spermatid development (GO:0007286)8.95039037
8cilium movement (GO:0003341)8.54769092
9regulation of cilium movement (GO:0003352)8.37417266
10male meiosis (GO:0007140)8.18335994
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.12126774
12synaptonemal complex organization (GO:0070193)7.48215321
13single fertilization (GO:0007338)7.34113118
14synaptonemal complex assembly (GO:0007130)7.26560232
15sperm capacitation (GO:0048240)6.77853936
16fertilization (GO:0009566)6.34525945
17negative regulation of inclusion body assembly (GO:0090084)6.24791125
18spermatogenesis (GO:0007283)6.18017020
19male gamete generation (GO:0048232)6.15973880
20microtubule depolymerization (GO:0007019)5.84075784
21gamete generation (GO:0007276)5.77571047
22DNA methylation involved in gamete generation (GO:0043046)5.73743751
23male meiosis I (GO:0007141)5.61610561
24organic cation transport (GO:0015695)5.30385142
25microtubule severing (GO:0051013)5.28589043
26germ cell development (GO:0007281)5.21154841
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.21001182
28regulation of inclusion body assembly (GO:0090083)5.16816726
29ventricular system development (GO:0021591)5.15680434
30calcium ion-dependent exocytosis (GO:0017156)5.00966089
31chromosome organization involved in meiosis (GO:0070192)4.90039653
32meiotic nuclear division (GO:0007126)4.87189171
33regulation of microtubule-based movement (GO:0060632)4.84916217
34cell recognition (GO:0008037)4.66711487
35meiosis I (GO:0007127)4.63374691
36multicellular organismal reproductive process (GO:0048609)4.54700749
37meiotic cell cycle (GO:0051321)4.47452332
38seminiferous tubule development (GO:0072520)4.46782449
39monoubiquitinated protein deubiquitination (GO:0035520)4.44905064
40tryptophan catabolic process (GO:0006569)4.22306286
41indole-containing compound catabolic process (GO:0042436)4.22306286
42indolalkylamine catabolic process (GO:0046218)4.22306286
43left/right pattern formation (GO:0060972)4.15018478
44protein polyglutamylation (GO:0018095)4.11498980
45indolalkylamine metabolic process (GO:0006586)4.10911137
46spermatid nucleus differentiation (GO:0007289)4.10236135
47response to pheromone (GO:0019236)4.04557017
48protein localization to cilium (GO:0061512)4.00045771
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.99866513
50chromosome condensation (GO:0030261)3.90117109
51photoreceptor cell maintenance (GO:0045494)3.81796444
52glycerol ether metabolic process (GO:0006662)3.76446488
53regulation of meiosis I (GO:0060631)3.75405497
54tryptophan metabolic process (GO:0006568)3.74775181
55DNA packaging (GO:0006323)3.72887799
56neural tube formation (GO:0001841)3.68435960
57kynurenine metabolic process (GO:0070189)3.66991291
58cellular ketone body metabolic process (GO:0046950)3.65235378
59detection of light stimulus involved in visual perception (GO:0050908)3.63617649
60detection of light stimulus involved in sensory perception (GO:0050962)3.63617649
61establishment of protein localization to Golgi (GO:0072600)3.62116754
62multicellular organismal development (GO:0007275)3.57077729
63genitalia morphogenesis (GO:0035112)3.54365800
64retinal cone cell development (GO:0046549)3.53748394
65gene silencing by RNA (GO:0031047)3.52172361
66ether metabolic process (GO:0018904)3.46949456
67L-fucose catabolic process (GO:0042355)3.46175030
68fucose catabolic process (GO:0019317)3.46175030
69L-fucose metabolic process (GO:0042354)3.46175030
70single strand break repair (GO:0000012)3.39087857
71meiotic cell cycle process (GO:1903046)3.31891736
72intraciliary transport (GO:0042073)3.31185144
73regulation of spindle checkpoint (GO:0090231)3.29744890
74ketone body metabolic process (GO:1902224)3.25853504
75behavioral response to ethanol (GO:0048149)3.22935975
76behavioral response to nicotine (GO:0035095)3.22689360
77microtubule-based movement (GO:0007018)3.20767566
78mitotic sister chromatid cohesion (GO:0007064)3.20684184
79axoneme assembly (GO:0035082)3.20040774
80reflex (GO:0060004)3.18445519
81microtubule polymerization or depolymerization (GO:0031109)3.16029603
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15218672
83cilium organization (GO:0044782)3.14449779
84protein K11-linked deubiquitination (GO:0035871)3.11800849
85negative regulation of organelle assembly (GO:1902116)3.10377250
86chaperone-mediated protein complex assembly (GO:0051131)3.04378645
87regulation of centriole replication (GO:0046599)3.03650646
88cilium assembly (GO:0042384)3.03635538
89cilium morphogenesis (GO:0060271)3.03008302
90polyol catabolic process (GO:0046174)2.99923128
91amino-acid betaine transport (GO:0015838)2.98961606
92carnitine transport (GO:0015879)2.98961606
93centriole assembly (GO:0098534)2.96036268
94nonmotile primary cilium assembly (GO:0035058)2.95565501
95negative regulation of mast cell activation (GO:0033004)2.95105630
96indole-containing compound metabolic process (GO:0042430)2.93410859
97nucleus organization (GO:0006997)2.90995874
98protein targeting to Golgi (GO:0000042)2.90209567
99centriole replication (GO:0007099)2.90167160
100left/right axis specification (GO:0070986)2.88047229
101carnitine transmembrane transport (GO:1902603)2.87988353
102lactate metabolic process (GO:0006089)2.87444418
103protein refolding (GO:0042026)2.86714111
104regulation of sarcomere organization (GO:0060297)2.86441950
105cellular component assembly involved in morphogenesis (GO:0010927)2.85250305
106nucleoside diphosphate phosphorylation (GO:0006165)2.81467454
107amine catabolic process (GO:0009310)2.77558641
108cellular biogenic amine catabolic process (GO:0042402)2.77558641
109alditol metabolic process (GO:0019400)2.74491192
110glycolytic process (GO:0006096)2.72700758
111auditory receptor cell stereocilium organization (GO:0060088)2.71743109
112regulation of cilium assembly (GO:1902017)2.71215455
113sexual reproduction (GO:0019953)2.70743023
114benzene-containing compound metabolic process (GO:0042537)2.69929344
115limb development (GO:0060173)2.68132275
116appendage development (GO:0048736)2.68132275
117sequestering of actin monomers (GO:0042989)2.67830076
118synapsis (GO:0007129)2.67424582
119thyroid hormone metabolic process (GO:0042403)2.66810336
120regulation of acrosome reaction (GO:0060046)2.66717422
121one-carbon compound transport (GO:0019755)2.66417124
122regulation of collateral sprouting (GO:0048670)2.65054677
123inner ear receptor stereocilium organization (GO:0060122)2.64780101
124gene silencing (GO:0016458)2.64471389
125peptidyl-glutamic acid modification (GO:0018200)2.64395483
126RNA localization (GO:0006403)2.64151181
127gamma-aminobutyric acid transport (GO:0015812)2.63850036
128microtubule bundle formation (GO:0001578)2.63805267
129regulation of action potential (GO:0098900)2.62545088
130retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61032598
131smoothened signaling pathway (GO:0007224)2.59234798
132regulation of establishment of cell polarity (GO:2000114)2.56463946
133photoreceptor cell development (GO:0042461)2.56164964
134RNA destabilization (GO:0050779)2.55689814
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55537696
136sister chromatid cohesion (GO:0007062)2.55337807
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53350025
138dopamine transport (GO:0015872)2.51605183
139cell projection assembly (GO:0030031)2.51505298
140regulation of hexokinase activity (GO:1903299)2.51499211
141regulation of glucokinase activity (GO:0033131)2.51499211
142sex differentiation (GO:0007548)2.49481912
143neuronal action potential (GO:0019228)2.49275140
144startle response (GO:0001964)2.48995779
145detection of mechanical stimulus involved in sensory perception (GO:0050974)2.48573650
146signal peptide processing (GO:0006465)2.47582546
147regulation of hippo signaling (GO:0035330)2.46281634
148DNA double-strand break processing (GO:0000729)2.45881645
149protein localization to Golgi apparatus (GO:0034067)2.45369407
150central nervous system neuron axonogenesis (GO:0021955)2.44860238
151presynaptic membrane assembly (GO:0097105)2.40706917
152proline transport (GO:0015824)2.38586084
153primary amino compound metabolic process (GO:1901160)2.37754077
154reciprocal meiotic recombination (GO:0007131)2.36782649
155reciprocal DNA recombination (GO:0035825)2.36782649
156fusion of sperm to egg plasma membrane (GO:0007342)12.5263615
157sperm motility (GO:0030317)12.2329220
158cilium or flagellum-dependent cell motility (GO:0001539)11.5591789
159multicellular organism reproduction (GO:0032504)10.7752739
160cell wall macromolecule metabolic process (GO:0044036)10.7140820
161cell wall macromolecule catabolic process (GO:0016998)10.7140820
162sperm-egg recognition (GO:0035036)10.6036146
163acrosome reaction (GO:0007340)10.4843234
164axonemal dynein complex assembly (GO:0070286)10.2131256
165epithelial cilium movement (GO:0003351)10.0612678
166acrosome assembly (GO:0001675)10.0408879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.82994397
2EZH2_22144423_ChIP-Seq_EOC_Human5.24258399
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50996478
4GBX2_23144817_ChIP-Seq_PC3_Human3.60388571
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09686767
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68851064
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59371566
8IGF1R_20145208_ChIP-Seq_DFB_Human2.53487647
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30670438
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30277376
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.26605231
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.26159842
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25405295
14P300_19829295_ChIP-Seq_ESCs_Human2.22064529
15VDR_22108803_ChIP-Seq_LS180_Human2.18913837
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08796002
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.08102707
18* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05710213
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.04804096
20ER_23166858_ChIP-Seq_MCF-7_Human1.99903915
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98204604
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95627899
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93792188
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92928499
25EWS_26573619_Chip-Seq_HEK293_Human1.92147216
26SMAD4_21799915_ChIP-Seq_A2780_Human1.91507545
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.87932900
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.86955126
29STAT3_23295773_ChIP-Seq_U87_Human1.83189781
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80510272
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80485591
32MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.76961515
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76849699
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76661131
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75733043
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72443828
37BCAT_22108803_ChIP-Seq_LS180_Human1.72012976
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71789754
39ZNF274_21170338_ChIP-Seq_K562_Hela1.68775130
40AR_25329375_ChIP-Seq_VCAP_Human1.66395229
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63560790
42* STAT1_17558387_ChIP-Seq_HELA_Human1.62782623
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.55479376
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.55463772
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53737256
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53412537
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50360363
48KDM2B_26808549_Chip-Seq_REH_Human1.49571549
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.46895796
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.44522460
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44203153
52RUNX2_22187159_ChIP-Seq_PCA_Human1.43117626
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42524737
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42360034
55* REST_21632747_ChIP-Seq_MESCs_Mouse1.41201760
56TCF4_22108803_ChIP-Seq_LS180_Human1.40877141
57CBP_20019798_ChIP-Seq_JUKART_Human1.40380485
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40380485
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.39880294
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39129043
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38713700
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35954844
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35852719
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34983887
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34983887
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.34321574
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34194208
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34028076
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33636708
70AR_21572438_ChIP-Seq_LNCaP_Human1.30430705
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.28426314
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28110847
73DROSHA_22980978_ChIP-Seq_HELA_Human1.27775120
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.27770435
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.26915699
76SOX2_19829295_ChIP-Seq_ESCs_Human1.26849913
77NANOG_19829295_ChIP-Seq_ESCs_Human1.26849913
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26478497
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.25845872
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.24915254
81TP53_22573176_ChIP-Seq_HFKS_Human1.24534712
82CDX2_22108803_ChIP-Seq_LS180_Human1.24421525
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24356698
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23665250
85RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23227599
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22833345
87RNF2_27304074_Chip-Seq_NSC_Mouse1.22577277
88IRF1_19129219_ChIP-ChIP_H3396_Human1.19741560
89SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18096125
90TAF15_26573619_Chip-Seq_HEK293_Human1.16464796
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15842764
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15044761
93CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13882283
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13372909
95TP53_16413492_ChIP-PET_HCT116_Human1.13334892
96GF1_26923725_Chip-Seq_HPCs_Mouse1.13297452
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13288089
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.13063830
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.12103607
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11701069
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.11604805
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11514746
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11499161
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.11019520
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11019520
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.10461128
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09961996
108* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09764120
109P53_21459846_ChIP-Seq_SAOS-2_Human1.08240591
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.08184947
111P53_22387025_ChIP-Seq_ESCs_Mouse1.07923853
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07822283
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.07244219
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07056046
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05743866
116* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05377569
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.04578750
118AHR_22903824_ChIP-Seq_MCF-7_Human1.03077486
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02965877
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02479205
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02087471
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.02006432
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.01813215
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00764050
125FUS_26573619_Chip-Seq_HEK293_Human1.00667669
126TP53_18474530_ChIP-ChIP_U2OS_Human1.00638921
127ERG_20517297_ChIP-Seq_VCAP_Human1.00305667
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99781802
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99686083
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98900334
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.97823651
132SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97331847
133P300_18555785_Chip-Seq_ESCs_Mouse0.96767005
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96625093
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.96391125
136TBL1_22424771_ChIP-Seq_293T_Human0.96226995
137ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95188313
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.92556278
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92442467
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92336055
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92100421
142NFYB_21822215_ChIP-Seq_K562_Human0.91860660
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.91127353
144* SPI1_26923725_Chip-Seq_HPCs_Mouse0.90997939
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90116736
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.89849510
147* TCF4_23295773_ChIP-Seq_U87_Human0.89537346
148SOX9_26525672_Chip-Seq_HEART_Mouse0.89309011
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89246347
150STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89102781
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.88485996
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88361801
153OCT1_27270436_Chip-Seq_PROSTATE_Human0.88288520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.75688795
2MP0001929_abnormal_gametogenesis5.47594644
3MP0008877_abnormal_DNA_methylation4.92214945
4MP0002653_abnormal_ependyma_morphology3.71077366
5MP0002210_abnormal_sex_determination3.63264425
6MP0002161_abnormal_fertility/fecundity3.32308617
7MP0003646_muscle_fatigue3.08556573
8MP0001145_abnormal_male_reproductive3.03187493
9MP0000653_abnormal_sex_gland2.82258002
10MP0003195_calcinosis2.37006165
11MP0001501_abnormal_sleep_pattern2.24747387
12MP0004043_abnormal_pH_regulation2.16996910
13MP0005410_abnormal_fertilization14.5343914
14MP0005670_abnormal_white_adipose1.96203896
15MP0009745_abnormal_behavioral_response1.94994491
16MP0002102_abnormal_ear_morphology1.90223582
17MP0006276_abnormal_autonomic_nervous1.83741817
18MP0002160_abnormal_reproductive_system1.83451180
19MP0008875_abnormal_xenobiotic_pharmacok1.82461041
20MP0002876_abnormal_thyroid_physiology1.78950165
21MP0000427_abnormal_hair_cycle1.78223568
22MP0000383_abnormal_hair_follicle1.76865523
23MP0006072_abnormal_retinal_apoptosis1.64487765
24MP0000631_abnormal_neuroendocrine_gland1.59703128
25MP0004133_heterotaxia1.55585395
26MP0001485_abnormal_pinna_reflex1.55029816
27MP0000372_irregular_coat_pigmentation1.50642044
28MP0008872_abnormal_physiological_respon1.46493609
29MP0004233_abnormal_muscle_weight1.45827302
30MP0005623_abnormal_meninges_morphology1.45281721
31MP0005645_abnormal_hypothalamus_physiol1.45212984
32MP0001984_abnormal_olfaction1.43864638
33MP0002735_abnormal_chemical_nociception1.38875342
34MP0003252_abnormal_bile_duct1.38435105
35MP0003136_yellow_coat_color1.37382528
36MP0010386_abnormal_urinary_bladder1.33030022
37MP0002064_seizures1.32885986
38MP0002837_dystrophic_cardiac_calcinosis1.32184649
39MP0002282_abnormal_trachea_morphology1.29712278
40MP0008789_abnormal_olfactory_epithelium1.28562345
41MP0001986_abnormal_taste_sensitivity1.27132708
42MP0004142_abnormal_muscle_tone1.25422913
43MP0002938_white_spotting1.21892065
44MP0002557_abnormal_social/conspecific_i1.20597115
45MP0005310_abnormal_salivary_gland1.20333318
46MP0001970_abnormal_pain_threshold1.19737296
47MP0002638_abnormal_pupillary_reflex1.16997811
48MP0010094_abnormal_chromosome_stability1.15909898
49MP0004924_abnormal_behavior1.14727832
50MP0005386_behavior/neurological_phenoty1.14727832
51MP0004885_abnormal_endolymph1.10899384
52MP0009046_muscle_twitch1.10647844
53MP0005174_abnormal_tail_pigmentation1.09666812
54MP0006292_abnormal_olfactory_placode1.08711536
55MP0009780_abnormal_chondrocyte_physiolo1.06597602
56MP0010678_abnormal_skin_adnexa1.05620691
57MP0008995_early_reproductive_senescence1.05608209
58MP0002067_abnormal_sensory_capabilities1.04676815
59MP0008058_abnormal_DNA_repair1.04436161
60MP0002733_abnormal_thermal_nociception1.04319339
61MP0001765_abnormal_ion_homeostasis1.04158576
62MP0005389_reproductive_system_phenotype1.02595467
63MP0005085_abnormal_gallbladder_physiolo0.99680137
64MP0005084_abnormal_gallbladder_morpholo0.97353226
65MP0001764_abnormal_homeostasis0.96982026
66MP0000026_abnormal_inner_ear0.96784014
67MP0003699_abnormal_female_reproductive0.96241293
68MP0000569_abnormal_digit_pigmentation0.96004459
69MP0005195_abnormal_posterior_eye0.94303360
70MP0000566_synostosis0.93222566
71MP0005647_abnormal_sex_gland0.92050740
72MP0003787_abnormal_imprinting0.92007352
73MP0000230_abnormal_systemic_arterial0.91341114
74MP0002138_abnormal_hepatobiliary_system0.90973087
75MP0004215_abnormal_myocardial_fiber0.89722559
76MP0004270_analgesia0.89430110
77MP0005167_abnormal_blood-brain_barrier0.86542623
78MP0003937_abnormal_limbs/digits/tail_de0.85486849
79MP0002909_abnormal_adrenal_gland0.84506585
80MP0001119_abnormal_female_reproductive0.83983391
81MP0004742_abnormal_vestibular_system0.82407391
82MP0003111_abnormal_nucleus_morphology0.81442891
83MP0002095_abnormal_skin_pigmentation0.81426470
84MP0005499_abnormal_olfactory_system0.80975341
85MP0005394_taste/olfaction_phenotype0.80975341
86MP0004085_abnormal_heartbeat0.80593235
87MP0003718_maternal_effect0.78630250
88MP0005451_abnormal_body_composition0.78312996
89MP0003329_amyloid_beta_deposits0.77964722
90MP0003878_abnormal_ear_physiology0.70889132
91MP0005377_hearing/vestibular/ear_phenot0.70889132
92MP0002736_abnormal_nociception_after0.69536737
93MP0004145_abnormal_muscle_electrophysio0.69424100
94MP0004859_abnormal_synaptic_plasticity0.62144315
95MP0002234_abnormal_pharynx_morphology0.61379010
96MP0003879_abnormal_hair_cell0.61005224
97MP0005646_abnormal_pituitary_gland0.58940396
98MP0003115_abnormal_respiratory_system0.56982107
99MP0004036_abnormal_muscle_relaxation0.55506786
100MP0001968_abnormal_touch/_nociception0.52133726
101MP0000358_abnormal_cell_content/0.51503150
102MP0003786_premature_aging0.49712401
103MP0003861_abnormal_nervous_system0.49692126
104MP0003011_delayed_dark_adaptation0.48749289
105MP0002063_abnormal_learning/memory/cond0.48313771
106MP0008057_abnormal_DNA_replication0.48008799
107MP0003635_abnormal_synaptic_transmissio0.47876907
108MP0001529_abnormal_vocalization0.47816963
109MP0002269_muscular_atrophy0.47340291
110MP0005551_abnormal_eye_electrophysiolog0.45399407
111MP0003880_abnormal_central_pattern0.44499193
112MP0002572_abnormal_emotion/affect_behav0.43490726
113MP0005636_abnormal_mineral_homeostasis0.43430362
114MP0003077_abnormal_cell_cycle0.43221257
115MP0002152_abnormal_brain_morphology0.43075956
116MP0005666_abnormal_adipose_tissue0.40366612
117MP0004811_abnormal_neuron_physiology0.39725944
118MP0001730_embryonic_growth_arrest0.38050657
119MP0008007_abnormal_cellular_replicative0.37469890
120MP0002734_abnormal_mechanical_nocicepti0.37406995
121MP0002928_abnormal_bile_duct0.37371061
122MP0003950_abnormal_plasma_membrane0.36893818
123MP0000751_myopathy0.36384881
124MP0000534_abnormal_ureter_morphology0.35779508
125MP0005395_other_phenotype0.34689006
126MP0002084_abnormal_developmental_patter0.34643925
127MP0001324_abnormal_eye_pigmentation0.33541067
128MP0005423_abnormal_somatic_nervous0.32801919
129MP0001502_abnormal_circadian_rhythm0.32162940
130MP0005397_hematopoietic_system_phenotyp0.32001048
131MP0001545_abnormal_hematopoietic_system0.32001048
132MP0002971_abnormal_brown_adipose0.31626081
133MP0003693_abnormal_embryo_hatching0.31304414
134MP0000604_amyloidosis0.30758750
135MP0005253_abnormal_eye_physiology0.30521872
136MP0003631_nervous_system_phenotype0.29262847
137MP0001293_anophthalmia0.28852874
138MP0002752_abnormal_somatic_nervous0.28041714
139MP0002106_abnormal_muscle_physiology0.27646381
140MP0002085_abnormal_embryonic_tissue0.27400760
141MP0006036_abnormal_mitochondrial_physio0.27349180
142MP0001440_abnormal_grooming_behavior0.26768986
143MP0000955_abnormal_spinal_cord0.26626694
144MP0001697_abnormal_embryo_size0.26283900
145MP0009278_abnormal_bone_marrow0.25996064
146MP0002272_abnormal_nervous_system0.25085575
147MP0003633_abnormal_nervous_system0.24454110
148MP0001963_abnormal_hearing_physiology0.24451464
149MP0002249_abnormal_larynx_morphology0.24082066
150MP0009115_abnormal_fat_cell0.23928507
151MP0001851_eye_inflammation0.23668148
152MP0001486_abnormal_startle_reflex0.23570248
153MP0002882_abnormal_neuron_morphology0.23563536
154MP0002169_no_abnormal_phenotype0.23535920
155MP0002229_neurodegeneration0.23522252
156MP0002873_normal_phenotype0.23391614

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.25326731
2Abnormal respiratory motile cilium morphology (HP:0005938)8.75769901
3Abnormal respiratory epithelium morphology (HP:0012253)8.75769901
4Rhinitis (HP:0012384)7.71961898
5Abnormal ciliary motility (HP:0012262)7.30328693
6Chronic bronchitis (HP:0004469)7.26212250
7Infertility (HP:0000789)6.79712079
8Nasal polyposis (HP:0100582)5.91734767
9Male infertility (HP:0003251)4.90830674
10Abnormality of the nasal mucosa (HP:0000433)4.79409529
11Bronchiectasis (HP:0002110)4.56026642
12Nephronophthisis (HP:0000090)4.46597456
13Bronchitis (HP:0012387)4.33119840
14Chronic hepatic failure (HP:0100626)4.15907300
15Abnormality of the renal medulla (HP:0100957)3.45600986
16Abnormal spermatogenesis (HP:0008669)3.25855621
17Hyperventilation (HP:0002883)3.19300306
18Recurrent otitis media (HP:0000403)3.18878237
19Congenital stationary night blindness (HP:0007642)3.18363521
20Attenuation of retinal blood vessels (HP:0007843)3.17542788
21Gaze-evoked nystagmus (HP:0000640)3.04976718
22Recurrent sinusitis (HP:0011108)2.96796040
23Progressive cerebellar ataxia (HP:0002073)2.93255346
24Tubulointerstitial nephritis (HP:0001970)2.83772973
25Genetic anticipation (HP:0003743)2.83231249
26Bony spicule pigmentary retinopathy (HP:0007737)2.78910538
27Intestinal atresia (HP:0011100)2.76100319
28Molar tooth sign on MRI (HP:0002419)2.73226948
29Abnormality of midbrain morphology (HP:0002418)2.73226948
30Abnormal rod and cone electroretinograms (HP:0008323)2.69218999
31Occipital encephalocele (HP:0002085)2.67900030
32Medial flaring of the eyebrow (HP:0010747)2.63001409
33Impulsivity (HP:0100710)2.62551204
34Sclerocornea (HP:0000647)2.62423039
35Anencephaly (HP:0002323)2.60682368
36Absent speech (HP:0001344)2.57309801
37Abolished electroretinogram (ERG) (HP:0000550)2.56894821
38Severe visual impairment (HP:0001141)2.53600643
39Abnormality of macular pigmentation (HP:0008002)2.46975553
40Tubular atrophy (HP:0000092)2.44815904
41Tubulointerstitial abnormality (HP:0001969)2.39736318
42Recurrent bronchitis (HP:0002837)2.37724900
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.35079985
44Male pseudohermaphroditism (HP:0000037)2.34453836
45Gonadotropin excess (HP:0000837)2.33658508
46Azoospermia (HP:0000027)2.33268322
47Type II lissencephaly (HP:0007260)2.32176996
48Congenital sensorineural hearing impairment (HP:0008527)2.29170994
49Furrowed tongue (HP:0000221)2.28378705
50Abnormality of the lower motor neuron (HP:0002366)2.28026588
51Increased corneal curvature (HP:0100692)2.25286212
52Keratoconus (HP:0000563)2.25286212
53Pendular nystagmus (HP:0012043)2.18377799
54Febrile seizures (HP:0002373)2.17967689
55Renal cortical cysts (HP:0000803)2.17610176
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17012515
57Focal seizures (HP:0007359)2.11960335
58Broad-based gait (HP:0002136)2.11831023
59Cholecystitis (HP:0001082)2.11795490
60Abnormal gallbladder physiology (HP:0012438)2.11795490
61Preaxial hand polydactyly (HP:0001177)2.07685170
62Widely spaced teeth (HP:0000687)2.07090848
63Postaxial foot polydactyly (HP:0001830)2.03491216
64Central scotoma (HP:0000603)2.03473394
65Retinitis pigmentosa (HP:0000510)2.02812295
66Decreased circulating renin level (HP:0003351)2.01498179
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3097473
68Absent/shortened dynein arms (HP:0200106)12.3821014
69Dynein arm defect of respiratory motile cilia (HP:0012255)12.3821014
70Fair hair (HP:0002286)1.98068452
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93161800
72Polyuria (HP:0000103)1.92624625
73Constricted visual fields (HP:0001133)1.91124822
74Cerebellar dysplasia (HP:0007033)1.89990545
75Tubulointerstitial fibrosis (HP:0005576)1.89429076
76Inability to walk (HP:0002540)1.89267359
77Gastrointestinal atresia (HP:0002589)1.87565494
78Dialeptic seizures (HP:0011146)1.86936148
79Amyotrophic lateral sclerosis (HP:0007354)1.86387737
80Heterotopia (HP:0002282)1.84980502
81Spastic tetraparesis (HP:0001285)1.84260662
82Large for gestational age (HP:0001520)1.83170387
83Protruding tongue (HP:0010808)1.82259720
84Stage 5 chronic kidney disease (HP:0003774)1.81368555
85Congenital hepatic fibrosis (HP:0002612)1.80620825
86Hypoplasia of the fovea (HP:0007750)1.80430381
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.80430381
88Focal motor seizures (HP:0011153)1.75375734
89Hyperalaninemia (HP:0003348)1.75028094
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75028094
91Abnormality of alanine metabolism (HP:0010916)1.75028094
92Microglossia (HP:0000171)1.74064948
93Pancreatic fibrosis (HP:0100732)1.72198404
94Supernumerary spleens (HP:0009799)1.70714312
95Oligodactyly (hands) (HP:0001180)1.70470956
96Astigmatism (HP:0000483)1.70351119
97Polydipsia (HP:0001959)1.70284497
98Abnormal drinking behavior (HP:0030082)1.70284497
99Abnormality of the fovea (HP:0000493)1.68050057
100Gait imbalance (HP:0002141)1.67798685
101Postaxial hand polydactyly (HP:0001162)1.67642066
102Clumsiness (HP:0002312)1.66843535
103Oculomotor apraxia (HP:0000657)1.66681161
104Abnormality of the dental root (HP:0006486)1.66364476
105Taurodontia (HP:0000679)1.66364476
106Abnormality of permanent molar morphology (HP:0011071)1.66364476
107Congenital primary aphakia (HP:0007707)1.65808050
108Small hand (HP:0200055)1.65526904
109Short ribs (HP:0000773)1.65114990
110Progressive inability to walk (HP:0002505)1.64700752
111Short foot (HP:0001773)1.64026160
112Abnormality of the renal cortex (HP:0011035)1.63707872
113Highly arched eyebrow (HP:0002553)1.63322193
114Dyschromatopsia (HP:0007641)1.61816626
115Abnormality of the labia minora (HP:0012880)1.61691660
116Choroideremia (HP:0001139)1.61443430
117Renal dysplasia (HP:0000110)1.61374680
118Abnormal biliary tract physiology (HP:0012439)1.60579990
119Bile duct proliferation (HP:0001408)1.60579990
120Abnormality of dentin (HP:0010299)1.56904397
121Cystic liver disease (HP:0006706)1.56271812
122Aplasia/Hypoplasia of the lens (HP:0008063)1.53515925
123Abnormality of molar morphology (HP:0011070)1.53404481
124Abnormality of molar (HP:0011077)1.53404481
125Fibular hypoplasia (HP:0003038)1.53382285
126Abnormality of the dental pulp (HP:0006479)1.50932892
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.50375643
128Bell-shaped thorax (HP:0001591)1.49207004
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48775343
130Absent epiphyses (HP:0010577)1.48775343
131Abnormality of renal excretion (HP:0011036)1.45441759
132Decreased central vision (HP:0007663)1.42241548
133Nephrogenic diabetes insipidus (HP:0009806)1.42224930
134Impaired proprioception (HP:0010831)1.41391109
135Absent frontal sinuses (HP:0002688)1.41084126
136Bundle branch block (HP:0011710)1.40676681
137Poor coordination (HP:0002370)1.36149615
138Papillary thyroid carcinoma (HP:0002895)1.35640767
139True hermaphroditism (HP:0010459)1.33854882
140Short thorax (HP:0010306)1.33532361
141Chronic sinusitis (HP:0011109)1.31833892
142Neurofibrillary tangles (HP:0002185)1.30586845
143Deformed sella turcica (HP:0002681)1.29545554
144Fatigable weakness (HP:0003473)1.29432321
145Abnormality of the neuromuscular junction (HP:0003398)1.29432321
146J-shaped sella turcica (HP:0002680)1.28918499
147Asymmetric septal hypertrophy (HP:0001670)1.28916891
148Facial cleft (HP:0002006)1.27292195
149Genital tract atresia (HP:0001827)1.26406352
150Short femoral neck (HP:0100864)1.25527498
151Median cleft lip (HP:0000161)1.24455441
152Vaginal atresia (HP:0000148)1.23860911
153Hemiparesis (HP:0001269)1.23265727
154Easy fatigability (HP:0003388)1.21201481
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21083969
156Abnormality of ocular smooth pursuit (HP:0000617)1.20317642
157Pancreatic cysts (HP:0001737)1.20064434
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.16072902
159Broad distal phalanx of finger (HP:0009836)1.15099506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.96277621
2PDK47.95373407
3PDK37.95373407
4TESK15.17257213
5PDK25.04220416
6PRKD34.99343182
7ICK3.66264588
8MAP4K23.50129754
9WNK32.67670009
10ADRBK22.58031512
11ACVR1B2.43672113
12PTK2B2.28523598
13INSRR2.26411221
14PNCK2.12570950
15OXSR11.95213957
16GRK11.93492716
17NUAK11.89132905
18STK381.88424701
19WNK41.87394097
20NEK21.83788009
21ZAK1.77311850
22STK391.71656309
23MUSK1.53710146
24NTRK31.50082908
25MST41.47979669
26CDK191.42109319
27TRIM281.34940549
28EEF2K1.33715263
29STK161.25487376
30TTK1.25290877
31PLK21.24104236
32TYRO31.23860864
33PLK41.20440316
34BCR1.20335786
35STK38L1.12296917
36MKNK21.11629254
37TNIK1.06896114
38CCNB11.04181537
39PRKCE1.03689325
40ERBB31.02723431
41ADRBK11.01856486
42BRAF0.98427297
43PDK10.97911720
44DYRK1B0.97724218
45STK30.95466813
46FER0.95402154
47MAPK150.95360106
48TXK0.93848894
49PAK30.89954118
50MAP3K60.89152099
51AKT30.84811197
52CHEK20.83825038
53MAP3K90.83577369
54CSNK1G20.81581530
55KSR20.81541028
56CSNK1G10.80958460
57TAOK10.80192873
58CAMKK20.79109866
59TGFBR10.79073772
60CDC70.78049669
61TNK20.78024686
62DAPK20.74111928
63ERBB40.73779988
64MAP3K70.73445480
65RIPK40.72978499
66DYRK30.72919737
67FGFR20.71869936
68PINK10.71544015
69MAP3K40.71212910
70TEC0.70141033
71PAK60.68497035
72CSNK1G30.66342751
73CSNK1A1L0.65797592
74TLK10.65175461
75LATS20.63888151
76BRSK20.62654868
77PIK3CG0.61973849
78LATS10.60820906
79EIF2AK30.59804925
80WNK10.57973032
81VRK10.57921108
82NTRK20.57819069
83PRKAA20.56384641
84PDPK10.51610031
85MKNK10.49694202
86MARK20.49529673
87MAPKAPK50.49339821
88BRD40.48559297
89MAPKAPK30.48268709
90PLK30.46775109
91PRKG10.46546718
92MAP2K70.46313886
93SGK20.46263717
94PIK3CA0.45775044
95EPHA40.44990868
96PKN10.44472708
97CHEK10.44347223
98CAMK1G0.43955245
99PRKACA0.42502649
100CHUK0.41754597
101CAMK10.41564495
102TIE10.41364621
103ARAF0.41189181
104TRPM70.40416011
105NLK0.39659684
106EPHA30.39652571
107PLK10.39276214
108PHKG20.39156542
109PHKG10.39156542
110PRKAA10.38868010
111FLT30.36945609
112MAP2K10.36735640
113CSNK1A10.36665951
114IRAK10.36560573
115RAF10.36191372
116OBSCN0.35649212
117MAP2K60.35081596
118ATM0.34474959
119PAK10.33597970
120PRKCA0.32357708
121MARK10.30188461
122ERBB20.30172951
123PASK0.28095674
124PRKCG0.26658631
125LMTK20.25964726
126CAMK2A0.25803109
127ATR0.24773335
128CDK30.24363586
129BMPR1B0.23586196
130MAPK130.23382326
131CDK90.23334670
132CDK150.20497158
133MAP2K40.20006096
134MOS0.19667823
135MTOR0.19422185
136CDK180.18330415
137STK110.18127158
138TESK20.18017526
139BRSK10.17387483
140CAMKK10.16719008
141BMPR20.16707214
142KSR10.15232446
143CDK11A0.14688662
144MAP3K50.14615577
145DYRK20.14437887
146PRKCZ0.13681843
147RPS6KB10.13452622
148NEK60.12695168
149PRKD20.11418112
150AURKA0.11089053
151WEE10.10809433
152CDK140.08750340
153CSNK1D0.08400538
154GSK3B0.08104154
155CASK0.07541161
156CDK10.06987637
157TAOK30.05553942
158CDK20.05232533
159MAP3K10.05170240
160MAPK100.03865079
161RPS6KA10.03063637
162MELK0.02289959
163PRKCQ0.01995118
164IRAK20.01794431
165RPS6KA30.01670604

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.10588461
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.60886860
3Fatty acid biosynthesis_Homo sapiens_hsa000613.44582614
4Pyruvate metabolism_Homo sapiens_hsa006203.11362489
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.02742573
6Basal transcription factors_Homo sapiens_hsa030223.00479885
7Linoleic acid metabolism_Homo sapiens_hsa005912.92305500
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88381082
9Butanoate metabolism_Homo sapiens_hsa006502.81644325
10Glucagon signaling pathway_Homo sapiens_hsa049222.62723453
11Phototransduction_Homo sapiens_hsa047442.55955960
12Oocyte meiosis_Homo sapiens_hsa041142.55785751
13Dorso-ventral axis formation_Homo sapiens_hsa043202.54786974
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29704131
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29668018
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.22983477
17Tryptophan metabolism_Homo sapiens_hsa003802.12812791
18Propanoate metabolism_Homo sapiens_hsa006402.08405009
19Fanconi anemia pathway_Homo sapiens_hsa034602.01431976
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00681065
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99415866
22Amphetamine addiction_Homo sapiens_hsa050311.97240704
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.96817262
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86426561
25Nitrogen metabolism_Homo sapiens_hsa009101.83967249
26ABC transporters_Homo sapiens_hsa020101.82416858
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79627241
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71126064
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.70119357
30Ether lipid metabolism_Homo sapiens_hsa005651.68858354
31Glycerolipid metabolism_Homo sapiens_hsa005611.67971762
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.67307479
33Chemical carcinogenesis_Homo sapiens_hsa052041.63813705
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63672407
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54598121
36Retinol metabolism_Homo sapiens_hsa008301.47817826
37Selenocompound metabolism_Homo sapiens_hsa004501.47797931
38Caffeine metabolism_Homo sapiens_hsa002321.47247484
39Long-term potentiation_Homo sapiens_hsa047201.45791193
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45345441
41beta-Alanine metabolism_Homo sapiens_hsa004101.41727915
42Histidine metabolism_Homo sapiens_hsa003401.37386557
43Renin secretion_Homo sapiens_hsa049241.35857952
44mRNA surveillance pathway_Homo sapiens_hsa030151.29938208
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29387383
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28782174
47Huntingtons disease_Homo sapiens_hsa050161.21417688
48Pentose phosphate pathway_Homo sapiens_hsa000301.21414524
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21316089
50Serotonergic synapse_Homo sapiens_hsa047261.20047964
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20043514
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19456703
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17756563
54Olfactory transduction_Homo sapiens_hsa047401.15857402
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.15214893
56GABAergic synapse_Homo sapiens_hsa047271.15101883
57RNA transport_Homo sapiens_hsa030131.14095767
58Non-homologous end-joining_Homo sapiens_hsa034501.14035593
59Estrogen signaling pathway_Homo sapiens_hsa049151.12742360
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.11457234
61PPAR signaling pathway_Homo sapiens_hsa033201.11114657
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08480695
63RNA degradation_Homo sapiens_hsa030181.06817362
64Peroxisome_Homo sapiens_hsa041461.05070141
65Synaptic vesicle cycle_Homo sapiens_hsa047211.04791801
66Mineral absorption_Homo sapiens_hsa049781.04369105
67Cardiac muscle contraction_Homo sapiens_hsa042601.03587311
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03261741
69Purine metabolism_Homo sapiens_hsa002301.01943138
70Cell cycle_Homo sapiens_hsa041101.01173873
71Protein export_Homo sapiens_hsa030601.01134896
72Insulin secretion_Homo sapiens_hsa049110.99636596
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99389774
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97776854
75Fructose and mannose metabolism_Homo sapiens_hsa000510.96436013
76Collecting duct acid secretion_Homo sapiens_hsa049660.94702742
77VEGF signaling pathway_Homo sapiens_hsa043700.92535346
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91325524
79Ovarian steroidogenesis_Homo sapiens_hsa049130.91101229
80Calcium signaling pathway_Homo sapiens_hsa040200.88982089
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88428186
82RNA polymerase_Homo sapiens_hsa030200.88143530
83Circadian entrainment_Homo sapiens_hsa047130.87761753
84Regulation of autophagy_Homo sapiens_hsa041400.86000698
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85843691
86Taste transduction_Homo sapiens_hsa047420.85237437
87Sphingolipid metabolism_Homo sapiens_hsa006000.84376234
88Inositol phosphate metabolism_Homo sapiens_hsa005620.81537441
89Glutamatergic synapse_Homo sapiens_hsa047240.80769792
90Hedgehog signaling pathway_Homo sapiens_hsa043400.78366231
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77935077
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75995732
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73228778
94cAMP signaling pathway_Homo sapiens_hsa040240.71593896
95Salivary secretion_Homo sapiens_hsa049700.70318915
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69901592
97Nicotine addiction_Homo sapiens_hsa050330.67984519
98Carbon metabolism_Homo sapiens_hsa012000.67830444
99Long-term depression_Homo sapiens_hsa047300.67730403
100Circadian rhythm_Homo sapiens_hsa047100.66133667
101Arachidonic acid metabolism_Homo sapiens_hsa005900.65865414
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.64100608
103Gastric acid secretion_Homo sapiens_hsa049710.61260812
104AMPK signaling pathway_Homo sapiens_hsa041520.58801071
105Fat digestion and absorption_Homo sapiens_hsa049750.57344951
106Oxytocin signaling pathway_Homo sapiens_hsa049210.57244799
107Lysine degradation_Homo sapiens_hsa003100.57045350
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56851697
109Metabolic pathways_Homo sapiens_hsa011000.56566921
110Endocytosis_Homo sapiens_hsa041440.55757178
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54583452
112Dopaminergic synapse_Homo sapiens_hsa047280.53691943
113Thyroid hormone synthesis_Homo sapiens_hsa049180.53501444
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.51019784
115One carbon pool by folate_Homo sapiens_hsa006700.50965309
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49050731
117Cocaine addiction_Homo sapiens_hsa050300.48464954
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46755086
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45941017
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.45328023
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.45210435
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45147201
123Fatty acid metabolism_Homo sapiens_hsa012120.44586351
124Biosynthesis of amino acids_Homo sapiens_hsa012300.43410736
125Antigen processing and presentation_Homo sapiens_hsa046120.42452911
126Cholinergic synapse_Homo sapiens_hsa047250.41644549
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41503149
128Wnt signaling pathway_Homo sapiens_hsa043100.36854420
129Glutathione metabolism_Homo sapiens_hsa004800.36332147
130Steroid biosynthesis_Homo sapiens_hsa001000.35909920
131Fatty acid degradation_Homo sapiens_hsa000710.35759196
132Pancreatic secretion_Homo sapiens_hsa049720.33956377
133Morphine addiction_Homo sapiens_hsa050320.33497875
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33172800
135Bile secretion_Homo sapiens_hsa049760.32444686
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31990235
137Arginine and proline metabolism_Homo sapiens_hsa003300.31116674
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28750659
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28436541
140Tyrosine metabolism_Homo sapiens_hsa003500.28405087
141MAPK signaling pathway_Homo sapiens_hsa040100.28297544
142Type I diabetes mellitus_Homo sapiens_hsa049400.27305127
143GnRH signaling pathway_Homo sapiens_hsa049120.25959774
144Asthma_Homo sapiens_hsa053100.25551902
145Choline metabolism in cancer_Homo sapiens_hsa052310.25049400
146Alcoholism_Homo sapiens_hsa050340.24057556
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20824636
148Homologous recombination_Homo sapiens_hsa034400.19953196
149Type II diabetes mellitus_Homo sapiens_hsa049300.18611778
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.16488884

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