EFCAB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.75856312
2binding of sperm to zona pellucida (GO:0007339)9.63490533
3cell-cell recognition (GO:0009988)9.29291854
4plasma membrane fusion (GO:0045026)9.22834095
5motile cilium assembly (GO:0044458)9.11636248
6epithelial cilium movement (GO:0003351)9.00301960
7spermatid development (GO:0007286)8.57199401
8male meiosis (GO:0007140)8.38645325
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.37834709
10negative regulation of cell killing (GO:0031342)8.37834709
11synaptonemal complex organization (GO:0070193)8.24443266
12reproduction (GO:0000003)8.22224879
13synaptonemal complex assembly (GO:0007130)7.87070963
14cell wall macromolecule metabolic process (GO:0044036)7.78540254
15cell wall macromolecule catabolic process (GO:0016998)7.78540254
16cilium movement (GO:0003341)7.71267361
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.64511087
18positive regulation of T cell cytokine production (GO:0002726)7.52019977
19regulation of cilium movement (GO:0003352)7.37790565
20tolerance induction (GO:0002507)7.03002573
21cellular response to interleukin-15 (GO:0071350)7.01690406
22DNA methylation involved in gamete generation (GO:0043046)6.86398155
23single fertilization (GO:0007338)6.83332203
24regulation of memory T cell differentiation (GO:0043380)6.25727149
25receptor recycling (GO:0001881)6.19210759
26sperm capacitation (GO:0048240)6.09340175
27negative regulation of inclusion body assembly (GO:0090084)5.98720909
28spermatogenesis (GO:0007283)5.96395484
29sleep (GO:0030431)5.94920737
30male gamete generation (GO:0048232)5.94363647
31fertilization (GO:0009566)5.92867521
32response to interleukin-15 (GO:0070672)5.88857623
33male meiosis I (GO:0007141)5.86512497
34organic cation transport (GO:0015695)5.59442250
35chromosome organization involved in meiosis (GO:0070192)5.48591103
36gamete generation (GO:0007276)5.45315657
37adenosine metabolic process (GO:0046085)5.19879491
38ventricular system development (GO:0021591)5.16410160
39seminiferous tubule development (GO:0072520)5.08408840
40cellular process involved in reproduction in multicellular organism (GO:0022412)5.07916204
41germ cell development (GO:0007281)5.06116389
42regulation of T cell cytokine production (GO:0002724)4.96102532
43meiotic nuclear division (GO:0007126)4.86929418
44positive regulation of heat generation (GO:0031652)4.82844714
45meiosis I (GO:0007127)4.78541099
46regulation of inclusion body assembly (GO:0090083)4.65916716
47regulation of fever generation (GO:0031620)4.61093638
48regulation of natural killer cell mediated immunity (GO:0002715)4.53112514
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.53112514
50meiotic cell cycle (GO:0051321)4.44786220
51microtubule depolymerization (GO:0007019)4.36722370
52cell recognition (GO:0008037)4.35316856
53positive regulation of prostaglandin secretion (GO:0032308)4.35120801
54cellular response to prostaglandin stimulus (GO:0071379)4.29139920
55calcium ion-dependent exocytosis (GO:0017156)4.29119257
56multicellular organismal reproductive process (GO:0048609)4.24858497
57protein K11-linked deubiquitination (GO:0035871)4.20566490
58regulation of microtubule-based movement (GO:0060632)4.19593812
59left/right pattern formation (GO:0060972)4.14641944
60positive regulation of T cell mediated immunity (GO:0002711)4.08263161
61regulation of leukocyte mediated cytotoxicity (GO:0001910)4.08218165
62tumor necrosis factor-mediated signaling pathway (GO:0033209)4.02247990
63regulation of T cell mediated cytotoxicity (GO:0001914)4.02137554
64microtubule severing (GO:0051013)3.97191187
65protein localization to cilium (GO:0061512)3.89484451
66negative T cell selection (GO:0043383)3.88612497
67negative thymic T cell selection (GO:0045060)3.87249746
68regulation of B cell receptor signaling pathway (GO:0050855)3.85211804
69male sex determination (GO:0030238)3.78712082
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.77340503
71regulation of T cell mediated immunity (GO:0002709)3.77200903
72genitalia morphogenesis (GO:0035112)3.76225951
73regulation of cell killing (GO:0031341)3.75707053
74cornea development in camera-type eye (GO:0061303)3.70006513
75gene silencing by RNA (GO:0031047)3.69448091
76leukotriene biosynthetic process (GO:0019370)3.69141386
77regulation of prostaglandin secretion (GO:0032306)3.67776738
78NIK/NF-kappaB signaling (GO:0038061)3.66440786
79positive regulation of defense response to virus by host (GO:0002230)3.65426765
80regulation of heat generation (GO:0031650)3.62965423
81DNA packaging (GO:0006323)3.51388680
82chaperone-mediated protein complex assembly (GO:0051131)3.51156898
83nuclear pore complex assembly (GO:0051292)3.48809853
84positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47408915
85mast cell activation (GO:0045576)3.45552020
86negative regulation of organelle assembly (GO:1902116)3.44466401
87mast cell degranulation (GO:0043303)3.44376174
88mast cell activation involved in immune response (GO:0002279)3.44376174
89chromosome condensation (GO:0030261)3.44242323
90intraciliary transport (GO:0042073)3.44197230
91regulation of spindle checkpoint (GO:0090231)3.43269336
92synapsis (GO:0007129)3.42139355
93negative regulation of cAMP-mediated signaling (GO:0043951)3.41007935
94regulation of immunoglobulin secretion (GO:0051023)3.38790260
95multicellular organismal development (GO:0007275)3.38357045
96positive regulation of osteoclast differentiation (GO:0045672)3.38113346
97monoubiquitinated protein deubiquitination (GO:0035520)3.37094685
98positive regulation of odontogenesis (GO:0042482)3.35729271
99positive regulation of T cell differentiation in thymus (GO:0033089)3.34583741
100meiotic cell cycle process (GO:1903046)3.32030136
101positive regulation of natural killer cell mediated immunity (GO:0002717)3.31805419
102coenzyme catabolic process (GO:0009109)3.29081800
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.27040010
104production of molecular mediator of immune response (GO:0002440)3.24153179
105alditol metabolic process (GO:0019400)3.22121618
106carnitine transmembrane transport (GO:1902603)3.21504561
107carnitine transport (GO:0015879)3.19168768
108amino-acid betaine transport (GO:0015838)3.19168768
109negative regulation of glycoprotein biosynthetic process (GO:0010561)3.18671174
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18551764
111keratan sulfate catabolic process (GO:0042340)3.15686060
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.15641314
113positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.15060428
114rRNA catabolic process (GO:0016075)3.14943847
115microtubule-based movement (GO:0007018)3.14795751
116negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.12955805
117negative regulation of T-helper cell differentiation (GO:0045623)3.12955805
118cofactor catabolic process (GO:0051187)3.11023769
119regulation of natural killer cell activation (GO:0032814)3.10982362
120folic acid metabolic process (GO:0046655)3.10910268
121metallo-sulfur cluster assembly (GO:0031163)3.10902193
122iron-sulfur cluster assembly (GO:0016226)3.10902193
123regulation of germinal center formation (GO:0002634)3.10827500
124glycerol ether metabolic process (GO:0006662)3.10462393
125regulation of T-helper 1 type immune response (GO:0002825)3.10068060
126positive regulation of icosanoid secretion (GO:0032305)3.09775004
127regulation of defense response to virus by host (GO:0050691)3.07444031
128mitotic sister chromatid cohesion (GO:0007064)3.06618089
129positive regulation of interleukin-2 production (GO:0032743)3.06287744
130regulation of lymphocyte mediated immunity (GO:0002706)3.05692978
131regulation of mast cell degranulation (GO:0043304)3.04648195
132positive regulation of fatty acid transport (GO:2000193)3.04470170
133protein polyglutamylation (GO:0018095)3.04051417
134cell aggregation (GO:0098743)3.03995281
135cartilage condensation (GO:0001502)3.03995281
136CD4-positive, alpha-beta T cell activation (GO:0035710)3.02018002
137positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.01168162
138establishment of protein localization to Golgi (GO:0072600)3.01001931
139positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.00547846
140regulation of centriole replication (GO:0046599)3.00308017
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.96443561
142axoneme assembly (GO:0035082)2.95480443
143regulation of mast cell activation involved in immune response (GO:0033006)2.94500064
144protein targeting to Golgi (GO:0000042)2.93454022
145positive regulation of interleukin-4 production (GO:0032753)2.92773250
146regulation of response to osmotic stress (GO:0047484)2.91771882
147regulation of leukocyte mediated immunity (GO:0002703)2.89860779
148T-helper cell differentiation (GO:0042093)2.89319134
149CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.89319134
150negative regulation of leukocyte mediated immunity (GO:0002704)2.89237815
151positive regulation of cytokine production involved in immune response (GO:0002720)2.89163432
152regulation of regulatory T cell differentiation (GO:0045589)2.88162462
153glycerol metabolic process (GO:0006071)2.87971461
154endosome organization (GO:0007032)2.87522000
155mammary gland alveolus development (GO:0060749)2.87314418
156negative regulation of T cell mediated immunity (GO:0002710)2.85765530
157positive regulation of bone remodeling (GO:0046852)2.84354337
158positive regulation of bone resorption (GO:0045780)2.84354337
159regulation of mast cell activation (GO:0033003)2.84155548
160positive regulation of circadian rhythm (GO:0042753)2.84130381
161positive regulation of actin cytoskeleton reorganization (GO:2000251)2.83878404
162nuclear pore organization (GO:0006999)2.83405440
163ether metabolic process (GO:0018904)2.82957207
164thymic T cell selection (GO:0045061)2.82732788
165regulation of T-helper 1 cell differentiation (GO:0045625)2.82544461
166negative regulation of skeletal muscle tissue development (GO:0048642)2.82180277
167microtubule polymerization or depolymerization (GO:0031109)2.81628272
168positive regulation of extracellular matrix organization (GO:1903055)2.81535467
169G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79916273
170positive regulation of cell killing (GO:0031343)2.79881702
171nucleus organization (GO:0006997)2.79794192
172T cell selection (GO:0045058)2.79550709
173lactate metabolic process (GO:0006089)2.79120925
174positive regulation of T-helper cell differentiation (GO:0045624)2.79080275
175regulation of cytokine production involved in inflammatory response (GO:1900015)2.78811751
176regulation of protein polyubiquitination (GO:1902914)2.78247055
177DNA alkylation (GO:0006305)2.77321270
178DNA methylation (GO:0006306)2.77321270
179regulation of histone H3-K9 methylation (GO:0051570)2.76725377
180negative regulation of DNA repair (GO:0045738)2.76631765
181regulation of meiosis I (GO:0060631)2.75882302
182protein refolding (GO:0042026)2.72033393
183nucleoside diphosphate phosphorylation (GO:0006165)2.71120127
184gene silencing (GO:0016458)2.67321083
185histone exchange (GO:0043486)2.67308800
186pore complex assembly (GO:0046931)2.66554068
187cilium or flagellum-dependent cell motility (GO:0001539)14.2997786
188fusion of sperm to egg plasma membrane (GO:0007342)12.2437310
189sperm motility (GO:0030317)11.5873452
190acrosome assembly (GO:0001675)10.8611819
191piRNA metabolic process (GO:0034587)10.5084088
192sperm-egg recognition (GO:0035036)10.3716783
193multicellular organism reproduction (GO:0032504)10.0730775
194axonemal dynein complex assembly (GO:0070286)10.0101464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53431757
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58962081
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46707521
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.07123125
5RUNX_20019798_ChIP-Seq_JUKART_Human3.68229578
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.13426079
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.48652840
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43529716
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.34316593
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.25209772
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22883068
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22512640
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15038253
14MYB_26560356_Chip-Seq_TH2_Human2.10204422
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.04695206
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.0609037
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.98735218
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97920640
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95966425
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93613312
21GATA3_26560356_Chip-Seq_TH2_Human1.92333070
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89446256
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.88769873
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86768849
25ZNF274_21170338_ChIP-Seq_K562_Hela1.86683693
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78825446
27GATA3_27048872_Chip-Seq_THYMUS_Human1.73423888
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.71066188
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70849322
30VDR_22108803_ChIP-Seq_LS180_Human1.66260402
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65720673
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61888134
33IRF1_19129219_ChIP-ChIP_H3396_Human1.59917774
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.59342378
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57609116
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57609116
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57539138
38PRDM14_20953172_ChIP-Seq_ESCs_Human1.56370983
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55904685
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55593265
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54764424
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.53477481
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52899525
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51791967
45STAT1_17558387_ChIP-Seq_HELA_Human1.51165050
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.50312940
47SMRT_27268052_Chip-Seq_Bcells_Human1.49878048
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48635134
49TAF15_26573619_Chip-Seq_HEK293_Human1.47351340
50BCAT_22108803_ChIP-Seq_LS180_Human1.45454844
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45130004
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.42840739
53GF1_26923725_Chip-Seq_HPCs_Mouse1.40434150
54STAT1_20625510_ChIP-Seq_HELA_Human1.40326167
55FOXH1_21741376_ChIP-Seq_ESCs_Human1.39848089
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34920203
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33765586
58MYB_26560356_Chip-Seq_TH1_Human1.33352027
59TP53_22573176_ChIP-Seq_HFKS_Human1.32489810
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32432882
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31070964
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30680980
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29896368
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29489543
65RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27700197
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.27095093
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25585000
68CBP_20019798_ChIP-Seq_JUKART_Human1.25585000
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25164996
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.25160111
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24755039
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24721622
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24282720
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23858707
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23023004
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22814245
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22286792
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.21940605
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21325914
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20380356
81CDX2_22108803_ChIP-Seq_LS180_Human1.20181532
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20066873
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19678381
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.19301452
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19144728
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18522544
87UTX_26944678_Chip-Seq_JUKART_Human1.18148298
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17741026
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.17405654
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17356727
91P300_19829295_ChIP-Seq_ESCs_Human1.16388113
92NANOG_19829295_ChIP-Seq_ESCs_Human1.16305225
93SOX2_19829295_ChIP-Seq_ESCs_Human1.16305225
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.16140628
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15811345
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15075216
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.14917720
98SCL_19346495_ChIP-Seq_HPC-7_Human1.14630191
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.13902206
100GATA3_26560356_Chip-Seq_TH1_Human1.12177095
101* OCT4_20526341_ChIP-Seq_ESCs_Human1.10768855
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10314444
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09686049
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09656024
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.09656024
106P53_21459846_ChIP-Seq_SAOS-2_Human1.08888811
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.08390681
108TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07731311
109RBPJ_21746931_ChIP-Seq_IB4_Human1.07384286
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.07245924
111GF1B_26923725_Chip-Seq_HPCs_Mouse1.06906186
112KDM2B_26808549_Chip-Seq_REH_Human1.05460540
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04936353
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.04559237
115AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04108631
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03902221
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03404225
118GBX2_23144817_ChIP-Seq_PC3_Human1.02969158
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.02760690
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02742324
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02530849
122GATA3_21867929_ChIP-Seq_TH1_Mouse1.02407842
123REST_21632747_ChIP-Seq_MESCs_Mouse1.02401074
124NANOG_20526341_ChIP-Seq_ESCs_Human1.02242510
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02202011
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01410335
127GATA2_21666600_ChIP-Seq_HMVEC_Human1.01181836
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00862302
129AR_20517297_ChIP-Seq_VCAP_Human1.00352942
130GATA1_22025678_ChIP-Seq_K562_Human0.99702656
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99541928
132* MYC_19829295_ChIP-Seq_ESCs_Human0.99310174
133RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99306266
134CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99116116
135RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98521410
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97769636
137* P300_27268052_Chip-Seq_Bcells_Human0.97705241
138ER_23166858_ChIP-Seq_MCF-7_Human0.97575275
139TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97134492
140MYC_27129775_Chip-Seq_CORNEA_Mouse0.97009078
141GATA3_21867929_ChIP-Seq_CD8_Mouse0.96364996
142SOX11_22085726_ChIP-Seq_ESNs_Mouse0.96161000
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95967860
144NFYB_21822215_ChIP-Seq_K562_Human0.95038002
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94474088
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94301923
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.94092216
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93629653
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.93001243
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91287524
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90901001
152STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90667082
153P300_18555785_Chip-Seq_ESCs_Mouse0.90605127
154ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89700676
155P53_22387025_ChIP-Seq_ESCs_Mouse0.89662064
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89145177
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89021662
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.88719396
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88580531
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.88481929
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.88031589
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87900895
163KLF4_19829295_ChIP-Seq_ESCs_Human0.87862622
164* ELF1_20517297_ChIP-Seq_JURKAT_Human0.87668537
165KLF4_18555785_Chip-Seq_ESCs_Mouse0.87071207
166TBL1_22424771_ChIP-Seq_293T_Human0.86981811
167TP53_22127205_ChIP-Seq_IMR90_Human0.86428921
168SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85788783
169AR_21909140_ChIP-Seq_LNCAP_Human0.84616827
170CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84395647
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84215227
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84092754
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83320459
174STAT3_18555785_Chip-Seq_ESCs_Mouse0.83255306
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82889268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.20030357
2MP0001929_abnormal_gametogenesis4.94400479
3MP0008877_abnormal_DNA_methylation4.91923850
4MP0005671_abnormal_response_to4.44090161
5MP0003724_increased_susceptibility_to4.22444951
6MP0002254_reproductive_system_inflammat3.69397309
7MP0002210_abnormal_sex_determination3.58665748
8MP0002282_abnormal_trachea_morphology3.26156775
9MP0000685_abnormal_immune_system3.22113795
10MP0002653_abnormal_ependyma_morphology2.97278995
11MP0003646_muscle_fatigue2.93722206
12MP0001145_abnormal_male_reproductive2.87401327
13MP0002161_abnormal_fertility/fecundity2.85962377
14MP0001348_abnormal_lacrimal_gland2.77375830
15MP0004134_abnormal_chest_morphology2.70592233
16MP0003763_abnormal_thymus_physiology2.57175037
17MP0001835_abnormal_antigen_presentation2.55150417
18MP0005670_abnormal_white_adipose2.54580205
19MP0000653_abnormal_sex_gland2.51843146
20MP0005000_abnormal_immune_tolerance2.47101431
21MP0002876_abnormal_thyroid_physiology2.39771428
22MP0003436_decreased_susceptibility_to2.26187898
23MP0002405_respiratory_system_inflammati2.15592712
24MP0001800_abnormal_humoral_immune2.14592874
25MP0003252_abnormal_bile_duct2.12072845
26MP0001501_abnormal_sleep_pattern2.07451906
27MP0005310_abnormal_salivary_gland2.05323462
28MP0005623_abnormal_meninges_morphology2.04862000
29MP0002723_abnormal_immune_serum2.00650946
30MP0005410_abnormal_fertilization13.6673944
31MP0002277_abnormal_respiratory_mucosa1.96563478
32MP0005387_immune_system_phenotype1.93354139
33MP0001790_abnormal_immune_system1.93354139
34MP0000465_gastrointestinal_hemorrhage1.91484337
35MP0003195_calcinosis1.89704111
36MP0001819_abnormal_immune_cell1.77868443
37MP0005503_abnormal_tendon_morphology1.76002404
38MP0002420_abnormal_adaptive_immunity1.74212539
39MP0003183_abnormal_peptide_metabolism1.70224828
40MP0002102_abnormal_ear_morphology1.69778591
41MP0005379_endocrine/exocrine_gland_phen1.69086469
42MP0001533_abnormal_skeleton_physiology1.65203828
43MP0006054_spinal_hemorrhage1.65174946
44MP0003172_abnormal_lysosome_physiology1.64229560
45MP0002138_abnormal_hepatobiliary_system1.63788240
46MP0002452_abnormal_antigen_presenting1.63334376
47MP0002933_joint_inflammation1.63094047
48MP0004043_abnormal_pH_regulation1.60341949
49MP0002160_abnormal_reproductive_system1.60279328
50MP0002148_abnormal_hypersensitivity_rea1.56970117
51MP0009333_abnormal_splenocyte_physiolog1.55619129
52MP0002419_abnormal_innate_immunity1.52438937
53MP0009250_abnormal_appendicular_skeleto1.52045283
54MP0001986_abnormal_taste_sensitivity1.51769226
55MP0002722_abnormal_immune_system1.51524295
56MP0008995_early_reproductive_senescence1.46840322
57MP0009764_decreased_sensitivity_to1.45013277
58MP0003879_abnormal_hair_cell1.44966775
59MP0005083_abnormal_biliary_tract1.44832599
60MP0005025_abnormal_response_to1.44323828
61MP0002398_abnormal_bone_marrow1.43472414
62MP0000015_abnormal_ear_pigmentation1.42850534
63MP0001968_abnormal_touch/_nociception1.39695953
64MP0009384_cardiac_valve_regurgitation1.39509777
65MP0000703_abnormal_thymus_morphology1.39270791
66MP0000716_abnormal_immune_system1.36786327
67MP0006082_CNS_inflammation1.34342249
68MP0000689_abnormal_spleen_morphology1.32969668
69MP0003786_premature_aging1.26855183
70MP0010155_abnormal_intestine_physiology1.25178326
71MP0002909_abnormal_adrenal_gland1.24699912
72MP0005360_urolithiasis1.22423044
73MP0002166_altered_tumor_susceptibility1.19447528
74MP0005551_abnormal_eye_electrophysiolog1.18692013
75MP0008961_abnormal_basal_metabolism1.18035584
76MP0008260_abnormal_autophagy1.16260414
77MP0009785_altered_susceptibility_to1.16134216
78MP0008007_abnormal_cellular_replicative1.13121989
79MP0005464_abnormal_platelet_physiology1.11700972
80MP0002928_abnormal_bile_duct1.08620964
81MP0003787_abnormal_imprinting1.05278248
82MP0004510_myositis1.02883322
83MP0001845_abnormal_inflammatory_respons1.02651629
84MP0008058_abnormal_DNA_repair0.98505098
85MP0002429_abnormal_blood_cell0.98129751
86MP0000163_abnormal_cartilage_morphology0.95664195
87MP0000751_myopathy0.94495656
88MP0005647_abnormal_sex_gland0.93905099
89MP0002115_abnormal_skeleton_extremities0.92394234
90MP0003950_abnormal_plasma_membrane0.92056967
91MP0001984_abnormal_olfaction0.91308618
92MP0000566_synostosis0.91265372
93MP0002127_abnormal_cardiovascular_syste0.90264398
94MP0001270_distended_abdomen0.89856733
95MP0000343_altered_response_to0.89570368
96MP0003638_abnormal_response/metabolism_0.88142067
97MP0003283_abnormal_digestive_organ0.88003030
98MP0004947_skin_inflammation0.87709101
99MP0001873_stomach_inflammation0.85906397
100MP0003111_abnormal_nucleus_morphology0.84999547
101MP0008057_abnormal_DNA_replication0.83615763
102MP0001851_eye_inflammation0.83320399
103MP0008872_abnormal_physiological_respon0.83174814
104MP0002006_tumorigenesis0.82522866
105MP0003866_abnormal_defecation0.82193451
106MP0005508_abnormal_skeleton_morphology0.80972545
107MP0003123_paternal_imprinting0.77699366
108MP0010094_abnormal_chromosome_stability0.77023470
109MP0005666_abnormal_adipose_tissue0.76480014
110MP0005377_hearing/vestibular/ear_phenot0.76160946
111MP0003878_abnormal_ear_physiology0.76160946
112MP0004197_abnormal_fetal_growth/weight/0.75445733
113MP0005646_abnormal_pituitary_gland0.75175862
114MP0008469_abnormal_protein_level0.74705539
115MP0001346_abnormal_lacrimal_gland0.74394788
116MP0001545_abnormal_hematopoietic_system0.74026379
117MP0005397_hematopoietic_system_phenotyp0.74026379
118MP0010329_abnormal_lipoprotein_level0.72132352
119MP0009046_muscle_twitch0.71450804
120MP0003656_abnormal_erythrocyte_physiolo0.71071029
121MP0001299_abnormal_eye_distance/0.68466517
122MP0002109_abnormal_limb_morphology0.66743502
123MP0003091_abnormal_cell_migration0.66402585
124MP0002113_abnormal_skeleton_development0.65092610
125MP0002116_abnormal_craniofacial_bone0.65068060
126MP0000427_abnormal_hair_cycle0.64938371
127MP0005075_abnormal_melanosome_morpholog0.64356712
128MP0003828_pulmonary_edema0.64154926
129MP0001963_abnormal_hearing_physiology0.61660597
130MP0005334_abnormal_fat_pad0.61395348
131MP0000230_abnormal_systemic_arterial0.61236693
132MP0000249_abnormal_blood_vessel0.61176600
133MP0005332_abnormal_amino_acid0.60685056
134MP0004484_altered_response_of0.60647132
135MP0002089_abnormal_postnatal_growth/wei0.60246685
136MP0009115_abnormal_fat_cell0.59802838
137MP0001730_embryonic_growth_arrest0.59000269
138MP0005389_reproductive_system_phenotype0.58740915
139MP0000432_abnormal_head_morphology0.58537270
140MP0002136_abnormal_kidney_physiology0.57600166
141MP0002114_abnormal_axial_skeleton0.55658742
142MP0003890_abnormal_embryonic-extraembry0.55169840
143MP0002736_abnormal_nociception_after0.55084846
144MP0002108_abnormal_muscle_morphology0.54632337
145MP0000049_abnormal_middle_ear0.53502154
146MP0003942_abnormal_urinary_system0.53072547
147MP0001765_abnormal_ion_homeostasis0.52422200
148MP0002163_abnormal_gland_morphology0.52194871
149MP0003699_abnormal_female_reproductive0.52144934
150MP0005390_skeleton_phenotype0.51389012
151MP0009278_abnormal_bone_marrow0.51299504
152MP0009697_abnormal_copulation0.48489312
153MP0004808_abnormal_hematopoietic_stem0.48058244
154MP0009780_abnormal_chondrocyte_physiolo0.46757649
155MP0001119_abnormal_female_reproductive0.46043416
156MP0005076_abnormal_cell_differentiation0.45895194
157MP0000647_abnormal_sebaceous_gland0.45884610
158MP0003329_amyloid_beta_deposits0.44978888
159MP0004233_abnormal_muscle_weight0.43931617
160MP0003115_abnormal_respiratory_system0.43585163
161MP0003011_delayed_dark_adaptation0.43487157
162MP0003186_abnormal_redox_activity0.42403763
163MP0000569_abnormal_digit_pigmentation0.41810837
164MP0004036_abnormal_muscle_relaxation0.41745910
165MP0000534_abnormal_ureter_morphology0.39951982
166MP0003755_abnormal_palate_morphology0.39188809
167MP0010307_abnormal_tumor_latency0.38554561
168MP0001672_abnormal_embryogenesis/_devel0.37672319
169MP0005380_embryogenesis_phenotype0.37672319
170MP0003795_abnormal_bone_structure0.37296005
171MP0000762_abnormal_tongue_morphology0.36898891
172MP0004742_abnormal_vestibular_system0.36691990
173MP0003045_fibrosis0.36112783
174MP0005375_adipose_tissue_phenotype0.35841035
175MP0002111_abnormal_tail_morphology0.35194655
176MP0002896_abnormal_bone_mineralization0.34270014
177MP0000358_abnormal_cell_content/0.34254577
178MP0006138_congestive_heart_failure0.32306636
179MP0001661_extended_life_span0.32058114
180MP0003693_abnormal_embryo_hatching0.30865676
181MP0000313_abnormal_cell_death0.30641587
182MP0003984_embryonic_growth_retardation0.30136706
183MP0005275_abnormal_skin_tensile0.30045877
184MP0003385_abnormal_body_wall0.28490213
185MP0003935_abnormal_craniofacial_develop0.28480234

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.98563420
2Absent/shortened dynein arms (HP:0200106)9.98563420
3Abnormal respiratory motile cilium physiology (HP:0012261)6.94605331
4Abnormal respiratory motile cilium morphology (HP:0005938)6.81037248
5Abnormal respiratory epithelium morphology (HP:0012253)6.81037248
6Rhinitis (HP:0012384)6.13628278
7Severe combined immunodeficiency (HP:0004430)5.74446074
8Epiphyseal dysplasia (HP:0002656)5.53536382
9Abnormal ciliary motility (HP:0012262)5.40014687
10B lymphocytopenia (HP:0010976)5.28736900
11Irregular epiphyses (HP:0010582)5.20920708
12Chronic bronchitis (HP:0004469)5.20231291
13Increased density of long bones (HP:0006392)5.17999040
14Abnormality of B cell number (HP:0010975)5.11682933
15Infertility (HP:0000789)4.97608263
16Nasal polyposis (HP:0100582)4.85074876
17Combined immunodeficiency (HP:0005387)4.58865407
18Abnormality of T cell number (HP:0011839)4.51496897
19IgG deficiency (HP:0004315)4.36633969
20Renal cortical cysts (HP:0000803)4.34801090
21Thyroiditis (HP:0100646)4.13706669
22Gastrointestinal infarctions (HP:0005244)4.01730313
23Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.98601669
24Absent epiphyses (HP:0010577)3.98601669
25Alveolar cell carcinoma (HP:0006519)3.94692540
26T lymphocytopenia (HP:0005403)3.92981484
27Abnormality of the nasal mucosa (HP:0000433)3.86816538
28Small epiphyses (HP:0010585)3.79366981
29Abnormality of T cells (HP:0002843)3.69881944
30Neoplasm of the tracheobronchial system (HP:0100552)3.64152910
31IgM deficiency (HP:0002850)3.63252444
32Vitreoretinal degeneration (HP:0000655)3.63147468
33Abnormality of eosinophils (HP:0001879)3.62954314
34Persistence of primary teeth (HP:0006335)3.60900947
35Nephronophthisis (HP:0000090)3.59564897
36Hypoplasia of the thymus (HP:0000778)3.57361773
37Degeneration of anterior horn cells (HP:0002398)3.48425799
38Abnormality of the anterior horn cell (HP:0006802)3.48425799
39Retrobulbar optic neuritis (HP:0100654)3.47634175
40Optic neuritis (HP:0100653)3.47634175
41Short femoral neck (HP:0100864)3.46170236
42Fibular hypoplasia (HP:0003038)3.45697265
43Abnormality of T cell physiology (HP:0011840)3.38970010
44Bronchiectasis (HP:0002110)3.31076717
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.30100060
46Orchitis (HP:0100796)3.24642844
47Flat capital femoral epiphysis (HP:0003370)3.23817228
48Abnormality of femoral epiphyses (HP:0006499)3.23662839
49Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.23662839
50Flattened epiphyses (HP:0003071)3.23069673
51Absent frontal sinuses (HP:0002688)3.22534117
52Hypoplastic ischia (HP:0003175)3.20971946
53Muscle fibrillation (HP:0010546)3.20965811
54Bronchitis (HP:0012387)3.20201195
55Keratoconjunctivitis (HP:0001096)3.16524727
56Cupped ribs (HP:0000887)3.16050862
57Flat acetabular roof (HP:0003180)3.13769022
58Abnormality of the epiphysis of the femoral head (HP:0010574)3.08711218
59Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.08303253
60Hypoplasia of the capital femoral epiphysis (HP:0003090)3.06192264
61Autoimmune thrombocytopenia (HP:0001973)3.02882069
62Genu varum (HP:0002970)3.01797461
63Attenuation of retinal blood vessels (HP:0007843)3.00799981
64Abnormality of the renal cortex (HP:0011035)3.00322576
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.98348150
66Myositis (HP:0100614)2.98011946
67Tongue fasciculations (HP:0001308)2.96724438
68Vasculitis (HP:0002633)2.94313585
69Abnormal tarsal ossification (HP:0008369)2.89533786
70Recurrent otitis media (HP:0000403)2.84223231
71Keratoconjunctivitis sicca (HP:0001097)2.78434847
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.78044556
73Abnormality of the renal medulla (HP:0100957)2.77864658
74Abnormality of the femoral head (HP:0003368)2.74481089
75Abnormality of the ischium (HP:0003174)2.73403755
76Brittle hair (HP:0002299)2.69800632
77Delayed epiphyseal ossification (HP:0002663)2.67950114
78Joint swelling (HP:0001386)2.65940597
79Abnormality of the prostate (HP:0008775)2.63791885
80Clumsiness (HP:0002312)2.62626702
81Gonadotropin excess (HP:0000837)2.55483801
82Abnormality of the vertebral endplates (HP:0005106)2.53167120
83Short ribs (HP:0000773)2.52970726
84Mediastinal lymphadenopathy (HP:0100721)2.50564751
85Hepatosplenomegaly (HP:0001433)2.49558613
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.48648968
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48648968
88Leukocytosis (HP:0001974)2.48240482
89Neonatal short-limb short stature (HP:0008921)2.48073234
90Eosinophilia (HP:0001880)2.46562987
91Abnormal spermatogenesis (HP:0008669)2.46371934
92Panhypogammaglobulinemia (HP:0003139)2.42619709
93Male infertility (HP:0003251)2.41280875
94Dysostosis multiplex (HP:0000943)2.41135193
95Disproportionate short-trunk short stature (HP:0003521)2.40050104
96Autoimmune hemolytic anemia (HP:0001890)2.38573314
97Hypoplasia of the odontoid process (HP:0003311)2.38173140
98Gangrene (HP:0100758)2.37515639
99Recurrent sinusitis (HP:0011108)2.36900160
100Thyroid-stimulating hormone excess (HP:0002925)2.35524615
101Abnormality of the lower motor neuron (HP:0002366)2.35124098
10211 pairs of ribs (HP:0000878)2.34423326
103Pulmonary infiltrates (HP:0002113)2.33400653
104Hemoptysis (HP:0002105)2.31363153
105Aplasia/hypoplasia of the femur (HP:0005613)2.29855052
106Tubular atrophy (HP:0000092)2.29449326
107Carpal bone hypoplasia (HP:0001498)2.29036192
108Conjunctival telangiectasia (HP:0000524)2.27055002
109Tubulointerstitial nephritis (HP:0001970)2.26529460
110Abnormality of dentin (HP:0010299)2.25689701
111Diplopia (HP:0000651)2.22595941
112Abnormality of binocular vision (HP:0011514)2.22595941
113Premature loss of primary teeth (HP:0006323)2.22178381
114Anorexia (HP:0002039)2.21942609
115Nonprogressive disorder (HP:0003680)2.20721337
116Pulmonary embolism (HP:0002204)2.20537230
117Aplasia/Hypoplasia of the fibula (HP:0006492)2.19862088
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17780702
119Irregular vertebral endplates (HP:0003301)2.14448925
120Pili torti (HP:0003777)2.14025402
121Abnormal foot bone ossification (HP:0010675)2.13863410
122Abnormal vertebral ossification (HP:0100569)2.12236558
123Facial diplegia (HP:0001349)2.11751294
124Metaphyseal irregularity (HP:0003025)2.08950946
125Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.07439001
126Recurrent fungal infections (HP:0002841)2.07052763
127Bony spicule pigmentary retinopathy (HP:0007737)2.03665407
128Granulocytopenia (HP:0001913)2.03557673
129Short thorax (HP:0010306)2.00648835
130Deformed sella turcica (HP:0002681)2.00485402
131Neoplasm of the lung (HP:0100526)2.00034154
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3934521
133Abolished electroretinogram (ERG) (HP:0000550)1.99365287
134Osteoarthritis (HP:0002758)1.99138616
135Arthropathy (HP:0003040)1.98099148
136Abnormal rod and cone electroretinograms (HP:0008323)1.97425622
137Hypoproteinemia (HP:0003075)1.96920404
138Short nail (HP:0001799)1.96645254
139Abnormality of polysaccharide metabolism (HP:0011012)1.96395824
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96395824
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96395824
142Amyotrophic lateral sclerosis (HP:0007354)1.96362181
143Flared iliac wings (HP:0002869)1.93515229
144Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.91948360
145Protuberant abdomen (HP:0001538)1.91907962
146Impaired proprioception (HP:0010831)1.91725116
147Metaphyseal dysplasia (HP:0100255)1.91218337
148Arterial thrombosis (HP:0004420)1.91045125
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90110154
150Abnormality of cells of the lymphoid lineage (HP:0012140)1.90045453
151Hypochromic anemia (HP:0001931)1.89827271
152Limited elbow extension (HP:0001377)1.89660605
153IgA deficiency (HP:0002720)1.88799778
154Abnormality of dental color (HP:0011073)1.88374167
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87590602
156Abnormality of the odontoid process (HP:0003310)1.87445411
157Recurrent bronchitis (HP:0002837)1.86847798
158Pulmonary fibrosis (HP:0002206)1.86135066
159Pancreatic cysts (HP:0001737)1.84591406
160Azoospermia (HP:0000027)1.84259557
161Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.83613214
162Impulsivity (HP:0100710)1.83430670
163Congenital stationary night blindness (HP:0007642)1.82526878
164Chronic obstructive pulmonary disease (HP:0006510)1.81973954
165Obstructive lung disease (HP:0006536)1.81973954
166Neoplasm of the respiratory system (HP:0100606)1.81441714
167Abnormality of the corticospinal tract (HP:0002492)1.80846305
168Increased neuronal autofluorescent lipopigment (HP:0002074)1.79286466
169Vertigo (HP:0002321)1.78844104
170J-shaped sella turcica (HP:0002680)1.78503793
171Metaphyseal cupping (HP:0003021)1.77658369
172Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76229962
173Coxa vara (HP:0002812)1.76126783
174Abnormality of the epiphyses of the hand (HP:0005924)1.75159766
175Mild short stature (HP:0003502)1.73250136
176Abnormality of the pubic bones (HP:0003172)1.69609975
177Atrophy/Degeneration involving motor neurons (HP:0007373)1.68400956
178Abnormality of carpal bone ossification (HP:0006257)1.67998864
179Abnormality of the frontal sinuses (HP:0002687)1.67157163
180Micromelia (HP:0002983)1.66651752
181Tubulointerstitial abnormality (HP:0001969)1.63048011
182Abnormality of the proximal phalanges of the hand (HP:0009834)1.62648062
183Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60043519
184Rhizomelia (HP:0008905)1.59914807
185Abnormality of the vitreous humor (HP:0004327)1.59882652
186Thoracolumbar scoliosis (HP:0002944)1.55099967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.68730974
2PDK47.68730974
3MAP4K25.19651159
4PDK25.13448641
5TESK15.12099464
6TAOK34.29540119
7FES4.23645154
8ACVR1B4.07932017
9BMPR24.07570495
10PRKD33.85833359
11ICK3.45255222
12STK392.95846035
13ADRBK22.90260208
14JAK12.89866523
15WNK42.80913385
16MAP3K32.53937632
17STK38L2.43622750
18PTK2B2.42824579
19TXK2.25344805
20GRK62.20631563
21PNCK2.16540808
22FRK2.14064946
23NME11.95181770
24MAP3K141.94082828
25NEK21.78283895
26STK31.73908765
27TLK11.73863314
28BCKDK1.61762218
29STK241.60218178
30IKBKB1.55988003
31MAP4K11.52012816
32CDC71.50491662
33MAP2K21.48439310
34BLK1.48095447
35BRD41.40933194
36SIK31.39038807
37ZAP701.27884653
38WNK11.21260782
39DYRK1B1.20632378
40IKBKE1.16236044
41DDR21.13517150
42ERN11.11820978
43STK381.06362024
44LCK1.03330528
45HCK1.02474384
46GRK11.00444285
47ADRBK10.93158738
48MAP3K130.89611592
49TYRO30.85759518
50INSRR0.82150039
51MAPK110.81982769
52CASK0.80139319
53PRKG20.79306874
54PDK10.79148834
55MAP3K70.78571860
56PASK0.74138642
57MAPK150.73974266
58PIK3CG0.73905822
59SYK0.69418707
60NUAK10.66916414
61CLK10.66533311
62MKNK20.65783395
63TYK20.65106627
64GRK70.64985673
65CDK120.63565175
66CSK0.63000245
67MARK30.62981076
68CAMK1G0.61464431
69TTK0.60432650
70MELK0.59909013
71MKNK10.59180007
72CHEK10.59109794
73TGFBR20.58806676
74NEK60.56387045
75TNK20.52808157
76AKT30.52409438
77LATS10.51438439
78KDR0.51121383
79PAK20.50751502
80LYN0.50305065
81MUSK0.50229845
82BUB10.49730183
83TEC0.49246518
84TRIM280.48590261
85MATK0.48236353
86DYRK1A0.47601556
87KIT0.45900732
88ITK0.44672667
89CHEK20.43433918
90MAP3K50.43041667
91TESK20.42422447
92TGFBR10.41618982
93CHUK0.41582096
94JAK30.41504404
95CCNB10.40401791
96BMX0.40137030
97PINK10.40086522
98MTOR0.39248410
99ATM0.38656435
100IGF1R0.38368530
101CDC42BPA0.38105929
102DYRK30.37516281
103MAPKAPK20.37151857
104ATR0.37140552
105PLK20.36028639
106PIM10.35282064
107RPS6KB10.34293658
108INSR0.33920422
109PRKACB0.32690196
110PRKCZ0.31748532
111IRAK10.31724059
112JAK20.29812830
113RPS6KA60.28642094
114PLK10.28368152
115WEE10.28343380
116MST40.28043088
117MAPK40.28029311
118PDPK10.27749646
119MAPK70.27233948
120CDK40.27196555
121YES10.26374813
122PRKCB0.26260622
123STK100.25803830
124TAOK10.25060117
125EEF2K0.24951575
126CSNK1D0.24890601
127CSF1R0.22395567
128PRKAA10.22333957
129EPHB10.21790530
130PAK10.21509875
131CAMK10.21039060
132EIF2AK10.20452021
133BCR0.20382844
134FYN0.20175522
135CAMK40.19794072
136PRKCD0.19273952
137PRKCG0.18291674
138RPS6KL10.18260899
139RPS6KC10.18260899
140PLK40.17675645
141PRKAA20.17167998
142PRKCQ0.16248119
143STK110.16079204
144CDK20.14774242
145AURKA0.14342784
146PLK30.13774353
147ROCK10.13749644
148GSK3A0.13713624
149CDK10.13351192
150BMPR1B0.12658401
151ZAK0.12031990
152UHMK10.11743417
153SRPK10.11423513
154LMTK20.11403306
155MAPK10.11159398
156MAPK80.10240469
157RIPK10.10234302
158PRKDC0.10077669
159PRKACG0.10059307
160MARK20.10017334
161AURKB0.09873700
162PAK40.09053203
163MAPK120.08755241
164GSK3B0.08367199
165MAP2K60.07731229
166CAMKK10.06755383
167PRKG10.06369470
168OXSR10.05922788
169RIPK40.05853499
170MAPK100.04471962
171EPHA20.03999701
172MAPK140.02802655
173SGK30.02508342
174CSNK2A10.02253311
175CDK60.01798230

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.31012741
2Fatty acid biosynthesis_Homo sapiens_hsa000614.05711032
3Primary immunodeficiency_Homo sapiens_hsa053404.05657165
4Pyruvate metabolism_Homo sapiens_hsa006203.68352679
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.36358322
6Basal transcription factors_Homo sapiens_hsa030223.22307200
7NF-kappa B signaling pathway_Homo sapiens_hsa040643.19066410
8Selenocompound metabolism_Homo sapiens_hsa004503.11765079
9Dorso-ventral axis formation_Homo sapiens_hsa043203.08682825
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.05260114
11Cyanoamino acid metabolism_Homo sapiens_hsa004603.01294545
12Propanoate metabolism_Homo sapiens_hsa006402.92082808
13Graft-versus-host disease_Homo sapiens_hsa053322.58233182
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46214184
15Glucagon signaling pathway_Homo sapiens_hsa049222.43279852
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31791175
17Linoleic acid metabolism_Homo sapiens_hsa005912.27875066
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.23698618
19Fanconi anemia pathway_Homo sapiens_hsa034602.20422799
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11423116
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10629820
22Osteoclast differentiation_Homo sapiens_hsa043802.08401319
23T cell receptor signaling pathway_Homo sapiens_hsa046602.06517668
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.05190418
25NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03781260
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96452016
27ECM-receptor interaction_Homo sapiens_hsa045121.95140082
28Protein digestion and absorption_Homo sapiens_hsa049741.93266845
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.91912616
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91111306
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.88056481
32PPAR signaling pathway_Homo sapiens_hsa033201.80051001
33Regulation of autophagy_Homo sapiens_hsa041401.78473851
34Pentose phosphate pathway_Homo sapiens_hsa000301.78187873
35Phototransduction_Homo sapiens_hsa047441.77696335
36Glycerolipid metabolism_Homo sapiens_hsa005611.69743295
37Oocyte meiosis_Homo sapiens_hsa041141.68538692
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.67435603
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67347455
40TNF signaling pathway_Homo sapiens_hsa046681.63763723
41Huntingtons disease_Homo sapiens_hsa050161.63108511
42RNA transport_Homo sapiens_hsa030131.60845949
43Allograft rejection_Homo sapiens_hsa053301.57833245
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53527160
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53313691
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49267400
47mRNA surveillance pathway_Homo sapiens_hsa030151.48793198
48Measles_Homo sapiens_hsa051621.45812305
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.44103846
50Autoimmune thyroid disease_Homo sapiens_hsa053201.40832220
51African trypanosomiasis_Homo sapiens_hsa051431.39346826
52Nitrogen metabolism_Homo sapiens_hsa009101.38710732
53Amphetamine addiction_Homo sapiens_hsa050311.35230495
54Type I diabetes mellitus_Homo sapiens_hsa049401.27452808
55Herpes simplex infection_Homo sapiens_hsa051681.27304260
56Fatty acid metabolism_Homo sapiens_hsa012121.24360437
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18611399
58Fat digestion and absorption_Homo sapiens_hsa049751.17472035
59Circadian rhythm_Homo sapiens_hsa047101.15102865
60Leishmaniasis_Homo sapiens_hsa051401.14004229
61Hedgehog signaling pathway_Homo sapiens_hsa043401.11714843
62Hematopoietic cell lineage_Homo sapiens_hsa046401.08515662
63Fructose and mannose metabolism_Homo sapiens_hsa000511.06687092
64Sphingolipid metabolism_Homo sapiens_hsa006001.04596002
65Glycerophospholipid metabolism_Homo sapiens_hsa005641.04420195
66Fatty acid degradation_Homo sapiens_hsa000711.03599706
67Non-homologous end-joining_Homo sapiens_hsa034501.03370387
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02440190
69Renin secretion_Homo sapiens_hsa049241.01532906
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99620782
71Purine metabolism_Homo sapiens_hsa002300.96141402
72Rheumatoid arthritis_Homo sapiens_hsa053230.96112600
73Cardiac muscle contraction_Homo sapiens_hsa042600.92427147
74Ether lipid metabolism_Homo sapiens_hsa005650.89664441
75Taste transduction_Homo sapiens_hsa047420.88386634
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86972117
77Antigen processing and presentation_Homo sapiens_hsa046120.83296174
78Morphine addiction_Homo sapiens_hsa050320.82151485
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81406475
80Carbon metabolism_Homo sapiens_hsa012000.81348454
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78711515
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73189629
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69923683
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.69835842
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69759145
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68837133
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68816741
88Long-term potentiation_Homo sapiens_hsa047200.68587673
89Toxoplasmosis_Homo sapiens_hsa051450.67916772
90Apoptosis_Homo sapiens_hsa042100.65684649
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64054317
92Butanoate metabolism_Homo sapiens_hsa006500.63505493
93Non-small cell lung cancer_Homo sapiens_hsa052230.63200373
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.62122813
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62084811
96ABC transporters_Homo sapiens_hsa020100.61844055
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61189873
98Steroid biosynthesis_Homo sapiens_hsa001000.60818366
99Legionellosis_Homo sapiens_hsa051340.59252833
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59047170
101Lysosome_Homo sapiens_hsa041420.58765802
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.58130188
103Histidine metabolism_Homo sapiens_hsa003400.57994425
104Arachidonic acid metabolism_Homo sapiens_hsa005900.57903866
105Tryptophan metabolism_Homo sapiens_hsa003800.56747598
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.54814980
107Retinol metabolism_Homo sapiens_hsa008300.53703006
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.52701005
109Estrogen signaling pathway_Homo sapiens_hsa049150.51690201
110Influenza A_Homo sapiens_hsa051640.51553733
111Notch signaling pathway_Homo sapiens_hsa043300.51295196
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51068059
113Cell cycle_Homo sapiens_hsa041100.50725237
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50370512
115MAPK signaling pathway_Homo sapiens_hsa040100.49919067
116Nicotine addiction_Homo sapiens_hsa050330.49206831
117AMPK signaling pathway_Homo sapiens_hsa041520.49175834
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48839556
119N-Glycan biosynthesis_Homo sapiens_hsa005100.47625540
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46995721
121Staphylococcus aureus infection_Homo sapiens_hsa051500.46587915
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46496607
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46285215
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46268447
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45828743
126Renin-angiotensin system_Homo sapiens_hsa046140.45734801
127Basal cell carcinoma_Homo sapiens_hsa052170.44723941
128Chemokine signaling pathway_Homo sapiens_hsa040620.44449044
129Sulfur metabolism_Homo sapiens_hsa009200.44207687
130Serotonergic synapse_Homo sapiens_hsa047260.43595092
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42417845
132Acute myeloid leukemia_Homo sapiens_hsa052210.40130282
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39630504
134VEGF signaling pathway_Homo sapiens_hsa043700.37990479
135Salivary secretion_Homo sapiens_hsa049700.37915128
136Asthma_Homo sapiens_hsa053100.37591167
137Calcium signaling pathway_Homo sapiens_hsa040200.37560923
138Viral carcinogenesis_Homo sapiens_hsa052030.37058298
139Proteasome_Homo sapiens_hsa030500.36713836
140Tuberculosis_Homo sapiens_hsa051520.36611865
141Bile secretion_Homo sapiens_hsa049760.36588819
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35555935
143Mineral absorption_Homo sapiens_hsa049780.34956649
144Thyroid hormone synthesis_Homo sapiens_hsa049180.34776008
145Focal adhesion_Homo sapiens_hsa045100.34311022
146FoxO signaling pathway_Homo sapiens_hsa040680.33560576
147Sulfur relay system_Homo sapiens_hsa041220.33485488
148Olfactory transduction_Homo sapiens_hsa047400.33297412
149Circadian entrainment_Homo sapiens_hsa047130.33154064
150Systemic lupus erythematosus_Homo sapiens_hsa053220.32537474
151RNA degradation_Homo sapiens_hsa030180.32412567
152Gastric acid secretion_Homo sapiens_hsa049710.31963438
153Pyrimidine metabolism_Homo sapiens_hsa002400.31924125
154Malaria_Homo sapiens_hsa051440.31880415
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.30257239
156Ovarian steroidogenesis_Homo sapiens_hsa049130.30125207
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29667226
158Biosynthesis of amino acids_Homo sapiens_hsa012300.27872419
159Metabolic pathways_Homo sapiens_hsa011000.26763593
160Endocytosis_Homo sapiens_hsa041440.25900796
161Chemical carcinogenesis_Homo sapiens_hsa052040.25111853
162Lysine degradation_Homo sapiens_hsa003100.24648416
163Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23560704
164Glutathione metabolism_Homo sapiens_hsa004800.23244090
165Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23025932
166HIF-1 signaling pathway_Homo sapiens_hsa040660.22877669
167B cell receptor signaling pathway_Homo sapiens_hsa046620.22754921
168Pancreatic secretion_Homo sapiens_hsa049720.22205060
169cAMP signaling pathway_Homo sapiens_hsa040240.22158398
170Wnt signaling pathway_Homo sapiens_hsa043100.21948149
171Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21542272

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