EFCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to nitric oxide (GO:0071731)7.69111973
2autophagic vacuole fusion (GO:0000046)7.62729320
3ribosomal small subunit assembly (GO:0000028)6.50500700
4positive regulation of digestive system process (GO:0060456)6.37169908
5DNA deamination (GO:0045006)6.33875110
6toxin transport (GO:1901998)5.86999871
7labyrinthine layer development (GO:0060711)5.76722451
8organelle membrane fusion (GO:0090174)5.55107246
9definitive hemopoiesis (GO:0060216)5.29544966
10peptidyl-proline hydroxylation (GO:0019511)5.14483530
11aggressive behavior (GO:0002118)5.06003018
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.02928385
13regulation of penile erection (GO:0060405)4.69968691
14glomerular filtration (GO:0003094)4.69658304
15protein hydroxylation (GO:0018126)4.51987745
16endothelium development (GO:0003158)4.51337284
17platelet dense granule organization (GO:0060155)4.50453331
18cell differentiation involved in metanephros development (GO:0072202)4.32173196
19pseudouridine synthesis (GO:0001522)4.26735015
20establishment of tissue polarity (GO:0007164)4.19420599
21establishment of planar polarity (GO:0001736)4.19420599
22maturation of SSU-rRNA (GO:0030490)4.17105949
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.16847170
24regulation of female receptivity (GO:0045924)4.15957968
25respiratory chain complex IV assembly (GO:0008535)4.14921903
26forebrain morphogenesis (GO:0048853)4.08853933
27renal filtration (GO:0097205)3.96506437
28tRNA methylation (GO:0030488)3.96230209
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.92816006
30termination of RNA polymerase III transcription (GO:0006386)3.92816006
314-hydroxyproline metabolic process (GO:0019471)3.91445836
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.90517612
33carnitine transmembrane transport (GO:1902603)3.81141740
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.79189186
35somite development (GO:0061053)3.74676950
36RNA destabilization (GO:0050779)3.74574765
37sleep (GO:0030431)3.74503616
38RNA methylation (GO:0001510)3.72170591
39endosome to pigment granule transport (GO:0043485)3.71866789
40endosome to melanosome transport (GO:0035646)3.71866789
41telomere maintenance via semi-conservative replication (GO:0032201)3.70329393
42cellular response to exogenous dsRNA (GO:0071360)3.63166382
43phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.63021545
44seminiferous tubule development (GO:0072520)3.62213964
45hematopoietic stem cell proliferation (GO:0071425)3.59164464
46cytochrome complex assembly (GO:0017004)3.58968677
47epithelial cell differentiation involved in kidney development (GO:0035850)3.54853295
48ribosomal small subunit biogenesis (GO:0042274)3.52818834
49cellular response to nitric oxide (GO:0071732)3.47712400
50cell proliferation in forebrain (GO:0021846)3.46399962
51carnitine transport (GO:0015879)3.45338430
52amino-acid betaine transport (GO:0015838)3.45338430
53regulation of skeletal muscle contraction (GO:0014819)3.45006821
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39231817
55rRNA modification (GO:0000154)3.37520525
56response to interferon-beta (GO:0035456)3.37091034
57viral transcription (GO:0019083)3.35893484
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33671172
59proteasome assembly (GO:0043248)3.33493758
60phagocytosis, engulfment (GO:0006911)3.31571625
61metallo-sulfur cluster assembly (GO:0031163)3.27510799
62iron-sulfur cluster assembly (GO:0016226)3.27510799
63female mating behavior (GO:0060180)3.26892581
64translational termination (GO:0006415)3.26818308
65axon ensheathment in central nervous system (GO:0032291)3.26171001
66central nervous system myelination (GO:0022010)3.26171001
67telomere maintenance via recombination (GO:0000722)3.25354437
68quaternary ammonium group transport (GO:0015697)3.24906454
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24131115
70maternal behavior (GO:0042711)3.19988748
71pattern specification involved in kidney development (GO:0061004)3.18602493
72neuronal stem cell maintenance (GO:0097150)3.16562369
73IMP biosynthetic process (GO:0006188)3.15887870
74cotranslational protein targeting to membrane (GO:0006613)3.14966557
75intra-S DNA damage checkpoint (GO:0031573)3.14617357
76protein complex biogenesis (GO:0070271)3.13927604
77purine nucleotide salvage (GO:0032261)3.13259768
78heart trabecula formation (GO:0060347)3.11688614
79RNA modification (GO:0009451)3.11136524
80protein targeting to ER (GO:0045047)3.10850686
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.10600370
82NADH dehydrogenase complex assembly (GO:0010257)3.10600370
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10600370
84DNA strand elongation involved in DNA replication (GO:0006271)3.09529264
85neurotransmitter catabolic process (GO:0042135)3.06425305
86protein localization to endoplasmic reticulum (GO:0070972)3.04626317
87megakaryocyte development (GO:0035855)3.02191865
88DNA strand elongation (GO:0022616)3.01687301
89telencephalon development (GO:0021537)3.01351896
90response to auditory stimulus (GO:0010996)3.01032990
91grooming behavior (GO:0007625)2.99510521
92tRNA modification (GO:0006400)2.98671961
93ribonucleoprotein complex biogenesis (GO:0022613)2.98455128
94fucose catabolic process (GO:0019317)2.98159375
95L-fucose metabolic process (GO:0042354)2.98159375
96L-fucose catabolic process (GO:0042355)2.98159375
97segment specification (GO:0007379)2.96814013
98xenobiotic catabolic process (GO:0042178)2.96377754
99ventricular septum morphogenesis (GO:0060412)2.94685565
100telomere maintenance via telomere lengthening (GO:0010833)2.94070041
101ribosome biogenesis (GO:0042254)2.91731904
102translational elongation (GO:0006414)2.91286121
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91092031
104rRNA methylation (GO:0031167)2.90790608
105organ formation (GO:0048645)2.90266766
106tRNA processing (GO:0008033)2.88888826
107DNA synthesis involved in DNA repair (GO:0000731)2.88752824
108mitochondrial respiratory chain complex assembly (GO:0033108)2.87775131
109negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86782972
110mature B cell differentiation involved in immune response (GO:0002313)2.85944222
111nephron tubule morphogenesis (GO:0072078)2.84941535
112nephron epithelium morphogenesis (GO:0072088)2.84941535
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83436800
114maturation of 5.8S rRNA (GO:0000460)2.83119794
115lymphoid progenitor cell differentiation (GO:0002320)2.82149405
116cellular component biogenesis (GO:0044085)2.81956637
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81607067
118defense response to protozoan (GO:0042832)2.80797486
119IMP metabolic process (GO:0046040)2.80236742
120organic cation transport (GO:0015695)2.78659034
121deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.77680900
122necroptotic process (GO:0070266)2.77358297
123negative regulation of telomere maintenance (GO:0032205)2.76858066
1247-methylguanosine RNA capping (GO:0009452)2.76317591
125RNA capping (GO:0036260)2.76317591
126peptidyl-histidine modification (GO:0018202)2.75362521
127response to nitrosative stress (GO:0051409)2.74602190
128CENP-A containing nucleosome assembly (GO:0034080)2.74414602
129DNA replication initiation (GO:0006270)2.74382037
130axonemal dynein complex assembly (GO:0070286)2.72539782
131histone H2A acetylation (GO:0043968)2.71063554
132response to methylmercury (GO:0051597)2.70940652
133positive regulation of vasculogenesis (GO:2001214)2.70717871
134deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69977242
135transcription-coupled nucleotide-excision repair (GO:0006283)2.69483968
1367-methylguanosine mRNA capping (GO:0006370)2.69074211
137regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)2.69069830
138mitochondrial DNA replication (GO:0006264)2.68767573
139lymph node development (GO:0048535)2.68558364
140neuron fate determination (GO:0048664)2.68552974
141regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68537537
142non-canonical Wnt signaling pathway (GO:0035567)2.67757474
143negative regulation of oligodendrocyte differentiation (GO:0048715)2.64844221
144heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64014053
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63103121
146viral life cycle (GO:0019058)2.63055478
147positive regulation of T cell differentiation in thymus (GO:0033089)2.62369860
148negative regulation of cAMP metabolic process (GO:0030815)2.61497701
149mitotic recombination (GO:0006312)2.61480324
150neutrophil activation involved in immune response (GO:0002283)2.61474090
151negative regulation of cyclic nucleotide metabolic process (GO:0030800)2.60760055
152positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.60691038
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60405812
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60405812
155nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60016858
156rRNA processing (GO:0006364)2.59571305
157parental behavior (GO:0060746)2.59068972
158cornea development in camera-type eye (GO:0061303)2.58745947
159dopamine transport (GO:0015872)2.58074431
160hyperosmotic salinity response (GO:0042538)2.57535106
161lens morphogenesis in camera-type eye (GO:0002089)2.57470721
162cellular response to reactive nitrogen species (GO:1902170)2.57407110
163thrombin receptor signaling pathway (GO:0070493)2.57067770
164positive regulation of icosanoid secretion (GO:0032305)2.56634603
165regulation of establishment of planar polarity (GO:0090175)2.56531116
166positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.55974777
167negative regulation of erythrocyte differentiation (GO:0045647)2.55973722
168translation (GO:0006412)2.55668704
169negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.54596662
170response to protozoan (GO:0001562)2.53996380
171cellular protein complex disassembly (GO:0043624)2.53328167
172positive regulation of granulocyte differentiation (GO:0030854)2.52596182
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.51327215
174tryptophan catabolic process (GO:0006569)2.51270873
175indole-containing compound catabolic process (GO:0042436)2.51270873
176indolalkylamine catabolic process (GO:0046218)2.51270873
177replication fork processing (GO:0031297)2.50818308
178GTP biosynthetic process (GO:0006183)2.50097622
179viral mRNA export from host cell nucleus (GO:0046784)2.49778884
180rRNA metabolic process (GO:0016072)2.49601930
181positive regulation of fatty acid transport (GO:2000193)2.49190042
182purine deoxyribonucleotide catabolic process (GO:0009155)2.48855808
183regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.48297760
184ncRNA processing (GO:0034470)2.47535943
185chromatin remodeling at centromere (GO:0031055)2.46340636
186ribosomal large subunit biogenesis (GO:0042273)2.46145462
187maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46083596
188secretory granule organization (GO:0033363)2.46030056
189energy homeostasis (GO:0097009)2.44966225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52723226
2E2F7_22180533_ChIP-Seq_HELA_Human4.64813332
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.94463391
4SCL_19346495_ChIP-Seq_HPC-7_Human3.63522579
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.12365613
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.03701220
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02814186
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01195628
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01030801
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00983499
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.97108516
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93907946
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82025187
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66945124
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.62791143
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61072147
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.60618247
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.59727614
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55699307
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.54980179
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.54802681
22GATA1_22025678_ChIP-Seq_K562_Human2.48086828
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.47090567
24VDR_23849224_ChIP-Seq_CD4+_Human2.45482937
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41788236
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.40227152
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39575048
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.31791753
29IGF1R_20145208_ChIP-Seq_DFB_Human2.29259476
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27355456
31HOXB4_20404135_ChIP-ChIP_EML_Mouse2.26092434
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26050558
33FOXP3_21729870_ChIP-Seq_TREG_Human2.24417964
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19271739
35ZNF274_21170338_ChIP-Seq_K562_Hela2.19060884
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19000160
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14073868
38EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12084618
39RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12084618
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11319571
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09778916
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09073658
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06680055
44MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02878248
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.98740832
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.92566680
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91555621
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87273257
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86965772
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86666000
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85536651
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85037752
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.83819248
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83049976
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.81448319
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81049093
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81018703
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80342250
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80307655
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80095322
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79952813
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79035712
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78541037
64SPI1_23547873_ChIP-Seq_NB4_Human1.78048691
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.76507516
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76476818
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75337662
68DROSHA_22980978_ChIP-Seq_HELA_Human1.74745057
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.73612872
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.71945536
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71515204
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70746208
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67252231
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66769711
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65999977
76ELK1_19687146_ChIP-ChIP_HELA_Human1.65023517
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64896130
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64855020
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.63160428
80CIITA_25753668_ChIP-Seq_RAJI_Human1.62959793
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62939060
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62358536
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.54788691
84GABP_19822575_ChIP-Seq_HepG2_Human1.54252903
85TTF2_22483619_ChIP-Seq_HELA_Human1.51847768
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51011034
87XRN2_22483619_ChIP-Seq_HELA_Human1.50852661
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47374657
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.46960590
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.46015123
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45259608
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44696276
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44136787
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.44136787
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43267535
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42667317
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42290447
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42170251
99RNF2_27304074_Chip-Seq_NSC_Mouse1.41147796
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36835879
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36753890
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33917902
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33235532
104IRF1_19129219_ChIP-ChIP_H3396_Human1.32144869
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.31990586
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.31386531
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30143828
108FUS_26573619_Chip-Seq_HEK293_Human1.29514463
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25875945
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24771536
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24080567
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23228134
113DCP1A_22483619_ChIP-Seq_HELA_Human1.22929391
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21950478
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20634845
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20291968
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19447806
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19119411
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19111077
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19006745
121VDR_21846776_ChIP-Seq_THP-1_Human1.18752415
122REST_21632747_ChIP-Seq_MESCs_Mouse1.17256838
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16365215
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15023681
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14428826
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.13987393
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12131107
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10787166
129YY1_22570637_ChIP-Seq_MALME-3M_Human1.08613390
130WDR5_24793694_ChIP-Seq_LNCAP_Human1.07471527
131BCAT_22108803_ChIP-Seq_LS180_Human1.06928411
132MYC_18940864_ChIP-ChIP_HL60_Human1.06763397
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06247715
134MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05175085
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04206359
136BCL6_27268052_Chip-Seq_Bcells_Human1.01464269
137TAF2_19829295_ChIP-Seq_ESCs_Human1.00594656
138AR_20517297_ChIP-Seq_VCAP_Human0.99178528
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98004192
140AR_25329375_ChIP-Seq_VCAP_Human0.97507287
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97356972
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.97171656
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97165816
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.96525241
145EWS_26573619_Chip-Seq_HEK293_Human0.96459025
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94994866
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93939020
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92522152
149ELK1_22589737_ChIP-Seq_MCF10A_Human0.92446851
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.92249749
151MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92142125
152GATA1_19941826_ChIP-Seq_K562_Human0.92119951
153CTCF_27219007_Chip-Seq_Bcells_Human0.90731884
154E2F1_21310950_ChIP-Seq_MCF-7_Human0.90670035
155NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90282156
156CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88676259
157IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86702849
158ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86592416
159GBX2_23144817_ChIP-Seq_PC3_Human0.85494751
160NANOG_20526341_ChIP-Seq_ESCs_Human0.85298427
161SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85148709
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84245163
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83934686
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.82745007
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.82587924
166REST_18959480_ChIP-ChIP_MESCs_Mouse0.81819844
167TP53_22573176_ChIP-Seq_HFKS_Human0.81802930
168VDR_22108803_ChIP-Seq_LS180_Human0.81781095
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80853062
170RUNX_20019798_ChIP-Seq_JUKART_Human0.80485907
171MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79619495
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79579068
173WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79541298
174IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79263149
175CBP_20019798_ChIP-Seq_JUKART_Human0.79263149
176BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78331514
177CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77990269
178NFE2_27457419_Chip-Seq_LIVER_Mouse0.77119769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.92925416
2MP0005083_abnormal_biliary_tract4.18588194
3MP0006292_abnormal_olfactory_placode3.81554452
4MP0003136_yellow_coat_color3.63634716
5MP0001188_hyperpigmentation3.52012150
6MP0002396_abnormal_hematopoietic_system3.43264142
7MP0009278_abnormal_bone_marrow3.42945765
8MP0005075_abnormal_melanosome_morpholog3.15283496
9MP0000383_abnormal_hair_follicle2.90771735
10MP0003693_abnormal_embryo_hatching2.66541666
11MP0008057_abnormal_DNA_replication2.62449122
12MP0001835_abnormal_antigen_presentation2.58827127
13MP0005174_abnormal_tail_pigmentation2.53380876
14MP0004147_increased_porphyrin_level2.45933723
15MP0008058_abnormal_DNA_repair2.41037873
16MP0005671_abnormal_response_to2.35193630
17MP0008007_abnormal_cellular_replicative2.29329095
18MP0002822_catalepsy2.29080095
19MP0004808_abnormal_hematopoietic_stem2.24196139
20MP0009785_altered_susceptibility_to2.24017699
21MP0000015_abnormal_ear_pigmentation2.23626307
22MP0001873_stomach_inflammation2.13677089
23MP0001986_abnormal_taste_sensitivity2.13567889
24MP0002095_abnormal_skin_pigmentation2.02989935
25MP0006276_abnormal_autonomic_nervous1.97372219
26MP0003763_abnormal_thymus_physiology1.93640256
27MP0003724_increased_susceptibility_to1.93413655
28MP0009697_abnormal_copulation1.91727406
29MP0003283_abnormal_digestive_organ1.89066437
30MP0005409_darkened_coat_color1.88693331
31MP0005646_abnormal_pituitary_gland1.87473469
32MP0004484_altered_response_of1.84383705
33MP0010094_abnormal_chromosome_stability1.83795291
34MP0002282_abnormal_trachea_morphology1.83674928
35MP0005464_abnormal_platelet_physiology1.78415556
36MP0004510_myositis1.73365359
37MP0005084_abnormal_gallbladder_morpholo1.71509925
38MP0002132_abnormal_respiratory_system1.69926796
39MP0003121_genomic_imprinting1.69574094
40MP0002398_abnormal_bone_marrow1.64294145
41MP0005025_abnormal_response_to1.63587085
42MP0001664_abnormal_digestion1.62616854
43MP0001764_abnormal_homeostasis1.55834466
44MP0003111_abnormal_nucleus_morphology1.54511689
45MP0002148_abnormal_hypersensitivity_rea1.53936290
46MP0000566_synostosis1.52962461
47MP0002249_abnormal_larynx_morphology1.48692695
48MP0005397_hematopoietic_system_phenotyp1.46727364
49MP0001545_abnormal_hematopoietic_system1.46727364
50MP0008877_abnormal_DNA_methylation1.45614623
51MP0010678_abnormal_skin_adnexa1.44025695
52MP0003786_premature_aging1.42218757
53MP0003077_abnormal_cell_cycle1.41178060
54MP0002420_abnormal_adaptive_immunity1.41125809
55MP0002928_abnormal_bile_duct1.39202089
56MP0000685_abnormal_immune_system1.39153042
57MP0001819_abnormal_immune_cell1.38491241
58MP0002723_abnormal_immune_serum1.37158048
59MP0000465_gastrointestinal_hemorrhage1.35868236
60MP0000689_abnormal_spleen_morphology1.33880167
61MP0002638_abnormal_pupillary_reflex1.33383202
62MP0000490_abnormal_crypts_of1.31713297
63MP0003806_abnormal_nucleotide_metabolis1.31655423
64MP0004142_abnormal_muscle_tone1.31627669
65MP0004858_abnormal_nervous_system1.31048894
66MP0005167_abnormal_blood-brain_barrier1.30369712
67MP0001293_anophthalmia1.29492111
68MP0002419_abnormal_innate_immunity1.29324000
69MP0000716_abnormal_immune_system1.28353917
70MP0005000_abnormal_immune_tolerance1.25655779
71MP0002909_abnormal_adrenal_gland1.25291170
72MP0000631_abnormal_neuroendocrine_gland1.25257300
73MP0000681_abnormal_thyroid_gland1.25122262
74MP0003122_maternal_imprinting1.24451919
75MP0005379_endocrine/exocrine_gland_phen1.23434321
76MP0002722_abnormal_immune_system1.22865857
77MP0002429_abnormal_blood_cell1.21568443
78MP0002452_abnormal_antigen_presenting1.19733451
79MP0000026_abnormal_inner_ear1.18282793
80MP0009379_abnormal_foot_pigmentation1.18103907
81MP0001800_abnormal_humoral_immune1.18037939
82MP0003315_abnormal_perineum_morphology1.17610064
83MP0004885_abnormal_endolymph1.17479676
84MP0001663_abnormal_digestive_system1.16814945
85MP0005645_abnormal_hypothalamus_physiol1.13666870
86MP0001853_heart_inflammation1.12886231
87MP0005171_absent_coat_pigmentation1.12052582
88MP0003787_abnormal_imprinting1.12038934
89MP0003632_abnormal_nervous_system1.11393957
90MP0003943_abnormal_hepatobiliary_system1.11146663
91MP0002733_abnormal_thermal_nociception1.08583408
92MP0004957_abnormal_blastocyst_morpholog1.07976684
93MP0005381_digestive/alimentary_phenotyp1.06882350
94MP0002234_abnormal_pharynx_morphology1.06528928
95MP0005595_abnormal_vascular_smooth1.05600764
96MP0000613_abnormal_salivary_gland1.02828851
97MP0000703_abnormal_thymus_morphology1.01033599
98MP0003186_abnormal_redox_activity0.99103269
99MP0010386_abnormal_urinary_bladder0.96989743
100MP0001186_pigmentation_phenotype0.96517353
101MP0000230_abnormal_systemic_arterial0.96279582
102MP0002938_white_spotting0.95344711
103MP0000313_abnormal_cell_death0.94133959
104MP0009333_abnormal_splenocyte_physiolog0.93951019
105MP0005220_abnormal_exocrine_pancreas0.91818057
106MP0002075_abnormal_coat/hair_pigmentati0.91460499
107MP0003866_abnormal_defecation0.90917736
108MP0001970_abnormal_pain_threshold0.90679264
109MP0000778_abnormal_nervous_system0.89779742
110MP0001529_abnormal_vocalization0.89518727
111MP0005367_renal/urinary_system_phenotyp0.87019616
112MP0000516_abnormal_urinary_system0.87019616
113MP0005387_immune_system_phenotype0.86552348
114MP0001790_abnormal_immune_system0.86552348
115MP0003942_abnormal_urinary_system0.85492586
116MP0006036_abnormal_mitochondrial_physio0.84063791
117MP0002210_abnormal_sex_determination0.83669988
118MP0002736_abnormal_nociception_after0.82310163
119MP0002557_abnormal_social/conspecific_i0.81057595
120MP0008995_early_reproductive_senescence0.80385455
121MP0005330_cardiomyopathy0.80092817
122MP0002163_abnormal_gland_morphology0.80058483
123MP0002876_abnormal_thyroid_physiology0.79247722
124MP0003567_abnormal_fetal_cardiomyocyte0.78927252
125MP0001845_abnormal_inflammatory_respons0.78683989
126MP0001440_abnormal_grooming_behavior0.77877874
127MP0003011_delayed_dark_adaptation0.77788062
128MP0001119_abnormal_female_reproductive0.77769526
129MP0002166_altered_tumor_susceptibility0.76208565
130MP0001968_abnormal_touch/_nociception0.75903019
131MP0001944_abnormal_pancreas_morphology0.75856659
132MP0002006_tumorigenesis0.75781903
133MP0000678_abnormal_parathyroid_gland0.75000808
134MP0000955_abnormal_spinal_cord0.74965985
135MP0009745_abnormal_behavioral_response0.74915441
136MP0003880_abnormal_central_pattern0.74375893
137MP0005535_abnormal_body_temperature0.74099754
138MP0001905_abnormal_dopamine_level0.74035103
139MP0002735_abnormal_chemical_nociception0.73405085
140MP0000462_abnormal_digestive_system0.72489210
141MP0006072_abnormal_retinal_apoptosis0.72409727
142MP0003879_abnormal_hair_cell0.72386586
143MP0002019_abnormal_tumor_incidence0.72287478
144MP0010155_abnormal_intestine_physiology0.71891916
145MP0010368_abnormal_lymphatic_system0.71705956
146MP0002272_abnormal_nervous_system0.70603050
147MP0003436_decreased_susceptibility_to0.70487492
148MP0006054_spinal_hemorrhage0.69661215
149MP0005365_abnormal_bile_salt0.68111658
150MP0002572_abnormal_emotion/affect_behav0.67156416
151MP0001851_eye_inflammation0.65149280
152MP0002693_abnormal_pancreas_physiology0.63201774
153MP0004782_abnormal_surfactant_physiolog0.62879122
154MP0001879_abnormal_lymphatic_vessel0.61917191
155MP0002277_abnormal_respiratory_mucosa0.60400631
156MP0002127_abnormal_cardiovascular_syste0.60013755
157MP0003948_abnormal_gas_homeostasis0.59570181
158MP0003959_abnormal_lean_body0.58527320
159MP0002067_abnormal_sensory_capabilities0.57502008
160MP0001501_abnormal_sleep_pattern0.55821214
161MP0001544_abnormal_cardiovascular_syste0.55802467
162MP0005385_cardiovascular_system_phenoty0.55802467
163MP0009250_abnormal_appendicular_skeleto0.55124550
164MP0003119_abnormal_digestive_system0.55113802
165MP0000249_abnormal_blood_vessel0.54999945

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.62911367
2Polycythemia (HP:0001901)4.55423693
3Increased intramyocellular lipid droplets (HP:0012240)4.33744446
4Increased muscle lipid content (HP:0009058)4.08233295
5Type I transferrin isoform profile (HP:0003642)4.00951281
6Absent/shortened dynein arms (HP:0200106)3.91504709
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.91504709
8Lipid accumulation in hepatocytes (HP:0006561)3.87567591
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.73751059
10Abnormal number of erythroid precursors (HP:0012131)3.50125392
11Petechiae (HP:0000967)3.48925048
12Reduced antithrombin III activity (HP:0001976)3.45926484
13Prolonged bleeding time (HP:0003010)3.39500778
14Cerebellar dysplasia (HP:0007033)3.36958256
15Confusion (HP:0001289)3.31321488
16Nephronophthisis (HP:0000090)3.28789447
17Abnormality of cells of the erythroid lineage (HP:0012130)3.24610603
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19522447
19Abnormal respiratory epithelium morphology (HP:0012253)3.19444877
20Abnormal respiratory motile cilium morphology (HP:0005938)3.19444877
21Reticulocytopenia (HP:0001896)3.18578414
22Pancytopenia (HP:0001876)3.18522373
23IgM deficiency (HP:0002850)3.17267962
24Type 2 muscle fiber atrophy (HP:0003554)3.17174445
25Abnormal ciliary motility (HP:0012262)3.13256990
26Birth length less than 3rd percentile (HP:0003561)3.12441510
27Hypoglycemic seizures (HP:0002173)3.09995621
28Thrombocytosis (HP:0001894)3.06329997
29Abnormal pupillary function (HP:0007686)3.05975983
30Interstitial pulmonary disease (HP:0006530)3.04187850
31Microvesicular hepatic steatosis (HP:0001414)3.03145602
32Polyphagia (HP:0002591)3.01731708
33Myelodysplasia (HP:0002863)2.98619866
34Hyperthyroidism (HP:0000836)2.97503912
35Glycosuria (HP:0003076)2.87546303
36Abnormality of urine glucose concentration (HP:0011016)2.87546303
37Stomatitis (HP:0010280)2.85788103
3811 pairs of ribs (HP:0000878)2.82985467
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80829033
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80829033
41Septo-optic dysplasia (HP:0100842)2.79973487
42Abnormal respiratory motile cilium physiology (HP:0012261)2.79657876
43Colon cancer (HP:0003003)2.75777711
44Muscle fiber atrophy (HP:0100295)2.73447975
45Increased IgE level (HP:0003212)2.72196343
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69492175
47Abnormality of renal resorption (HP:0011038)2.65774285
48Severe global developmental delay (HP:0011344)2.63602340
49Bone marrow hypocellularity (HP:0005528)2.62800025
503-Methylglutaconic aciduria (HP:0003535)2.59279771
51Pallor (HP:0000980)2.59169267
52Abnormality of the renal medulla (HP:0100957)2.57266851
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55325040
54Onycholysis (HP:0001806)2.53593422
55Clubbing of toes (HP:0100760)2.52544694
56Partial agenesis of the corpus callosum (HP:0001338)2.51496509
57Hypothermia (HP:0002045)2.51406473
58Acute lymphatic leukemia (HP:0006721)2.49826428
59Hypercortisolism (HP:0001578)2.49509321
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49157177
61Abnormal protein N-linked glycosylation (HP:0012347)2.49157177
62Abnormal protein glycosylation (HP:0012346)2.49157177
63Abnormal glycosylation (HP:0012345)2.49157177
64Loss of speech (HP:0002371)2.46775905
65Syringomyelia (HP:0003396)2.44018792
66Spinal cord lesions (HP:0100561)2.44018792
67Weak cry (HP:0001612)2.43529866
68Abnormality of the preputium (HP:0100587)2.42531428
69Abnormality of the columella (HP:0009929)2.41242293
70Chronic otitis media (HP:0000389)2.40075785
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38739812
72Maternal diabetes (HP:0009800)2.36414512
73Patchy hypopigmentation of hair (HP:0011365)2.35983020
74Renal Fanconi syndrome (HP:0001994)2.35709518
75Nonprogressive disorder (HP:0003680)2.33967306
76Elevated erythrocyte sedimentation rate (HP:0003565)2.32073580
77Gonadotropin excess (HP:0000837)2.29030539
78Abnormal rod and cone electroretinograms (HP:0008323)2.28741777
79Neutropenia (HP:0001875)2.28676702
80Epistaxis (HP:0000421)2.28365300
81Abnormal hair whorl (HP:0010721)2.28151429
82Abnormality of B cell number (HP:0010975)2.26861472
83White forelock (HP:0002211)2.21967050
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19789534
85Abnormality of alanine metabolism (HP:0010916)2.19789534
86Hyperalaninemia (HP:0003348)2.19789534
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19037680
88Hyperinsulinemic hypoglycemia (HP:0000825)2.17588601
89Exertional dyspnea (HP:0002875)2.17250200
90Abnormality of the prostate (HP:0008775)2.16485812
91Meckel diverticulum (HP:0002245)2.16144855
92Abnormal platelet volume (HP:0011876)2.16029144
93Cortical visual impairment (HP:0100704)2.15712405
94Chromsome breakage (HP:0040012)2.15367204
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.14969459
96Abnormality of the anterior horn cell (HP:0006802)2.13620469
97Degeneration of anterior horn cells (HP:0002398)2.13620469
98Bulbar palsy (HP:0001283)2.13151839
99Truncus arteriosus (HP:0001660)2.12786846
100Spontaneous hematomas (HP:0007420)2.11448637
101Increased mean platelet volume (HP:0011877)2.10177274
102Neurodegeneration (HP:0002180)2.09704824
103Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09189363
104Midline defect of the nose (HP:0004122)2.08321142
105Hypertensive crisis (HP:0100735)2.08235256
106Pancreatic fibrosis (HP:0100732)2.07536623
107Aplasia/Hypoplasia of the spleen (HP:0010451)2.07500966
108Optic nerve coloboma (HP:0000588)2.07345021
109Increased serum lactate (HP:0002151)2.06784232
110B lymphocytopenia (HP:0010976)2.05913588
111Myositis (HP:0100614)2.05511815
112Amaurosis fugax (HP:0100576)2.05213399
113Hepatocellular necrosis (HP:0001404)2.05177541
114Mesangial abnormality (HP:0001966)2.04879230
115Abnormality of endocrine pancreas physiology (HP:0012093)2.04796900
116Abnormality of the pancreatic islet cells (HP:0006476)2.04796900
117Optic neuritis (HP:0100653)2.04266138
118Retrobulbar optic neuritis (HP:0100654)2.04266138
119Abnormality of the ileum (HP:0001549)2.04000572
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02633187
121Mitochondrial inheritance (HP:0001427)2.02433723
122Cerebral palsy (HP:0100021)2.01583030
123Macrocytic anemia (HP:0001972)2.01551005
124Medial flaring of the eyebrow (HP:0010747)1.99802967
125IgG deficiency (HP:0004315)1.99745104
126Pancreatic cysts (HP:0001737)1.99228332
127Increased hepatocellular lipid droplets (HP:0006565)1.98434821
128Encephalitis (HP:0002383)1.98349232
129Oral leukoplakia (HP:0002745)1.95765598
130Attenuation of retinal blood vessels (HP:0007843)1.94234699
131Abnormality of DNA repair (HP:0003254)1.94231933
132Respiratory distress (HP:0002098)1.93400380
133Purpura (HP:0000979)1.93175237
134Abnormality of chromosome stability (HP:0003220)1.92033765
135Hyperphosphaturia (HP:0003109)1.91874315
136Abnormality of the axillary hair (HP:0100134)1.91101571
137Abnormality of secondary sexual hair (HP:0009888)1.91101571
138Increased CSF lactate (HP:0002490)1.90686948
139Pseudobulbar signs (HP:0002200)1.88191397
140Premature graying of hair (HP:0002216)1.87878274
141Abnormal eating behavior (HP:0100738)1.86273593
142Acute myeloid leukemia (HP:0004808)1.86088464
143Asplenia (HP:0001746)1.85818064
144Lactic acidosis (HP:0003128)1.85056341
145Congenital hepatic fibrosis (HP:0002612)1.84526140
146Increased neuronal autofluorescent lipopigment (HP:0002074)1.84328835
147Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84237179
148Cystic liver disease (HP:0006706)1.83541452
149Hepatic necrosis (HP:0002605)1.82861285
150Albinism (HP:0001022)1.82735445
151Abnormal platelet function (HP:0011869)1.82724925
152Impaired platelet aggregation (HP:0003540)1.82724925
153Respiratory difficulties (HP:0002880)1.81935327
154Panhypogammaglobulinemia (HP:0003139)1.81023125
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79552948
156Rhabdomyosarcoma (HP:0002859)1.78354341
157Abnormality of the 4th metacarpal (HP:0010012)1.78352121
158Lymphoma (HP:0002665)1.78259659
159Prostate neoplasm (HP:0100787)1.77272741
160True hermaphroditism (HP:0010459)1.76791601
161Congenital stationary night blindness (HP:0007642)1.76110184
162Acute necrotizing encephalopathy (HP:0006965)1.75886498
163Aplasia/Hypoplasia of the thymus (HP:0010515)1.74530912
164Generalized hypopigmentation (HP:0007513)1.74497071
165Obstructive lung disease (HP:0006536)1.74083544
166Chronic obstructive pulmonary disease (HP:0006510)1.74083544
167Brushfield spots (HP:0001088)1.72945075
168Joint stiffness (HP:0001387)1.72277562
169Chronic sinusitis (HP:0011109)1.70536505
170Gingival bleeding (HP:0000225)1.69602102
171Symptomatic seizures (HP:0011145)1.69244703
172Humeroradial synostosis (HP:0003041)1.68169431
173Synostosis involving the elbow (HP:0003938)1.68169431
174Ketosis (HP:0001946)1.67927327
175Adactyly (HP:0009776)1.67501758
176Hypergammaglobulinemia (HP:0010702)1.67237981
177Large for gestational age (HP:0001520)1.67232866
178Myoglobinuria (HP:0002913)1.65967087
179Type II lissencephaly (HP:0007260)1.65963882
180Visual hallucinations (HP:0002367)1.65548435
181Menorrhagia (HP:0000132)1.64967721
182Gait imbalance (HP:0002141)1.64271762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.90810686
2PNCK3.26212500
3IRAK33.11071789
4IRAK43.00953271
5WEE13.00426052
6MAP3K122.99807808
7MUSK2.64674297
8MAPK72.57879231
9STK162.57085287
10MAPK152.39390407
11TNIK2.34722783
12EPHB22.34227266
13ZAK2.14234587
14TXK2.10146270
15NTRK22.03017667
16TEC2.00653208
17PINK11.95630267
18MAP2K71.95186162
19SCYL21.93039575
20VRK11.93009509
21KIT1.92648263
22MAP4K11.91812452
23CASK1.90600097
24CDK191.88173360
25FLT31.85697660
26GRK11.78832244
27PLK41.77489718
28CCNB11.77318091
29NME21.73687739
30TBK11.72801904
31BTK1.65583039
32MAP3K61.61957902
33IRAK11.54695325
34SRPK11.52568240
35PRKD31.47599565
36TSSK61.47198197
37ADRBK21.45141302
38TIE11.44382975
39TNK21.43915454
40ACVR1B1.37941619
41MKNK11.35939172
42EIF2AK31.33876091
43BUB11.33563945
44DYRK31.24854236
45BRSK21.24568266
46NUAK11.21743869
47IKBKE1.21715758
48MAP4K21.17891162
49MAP2K41.17170441
50MAP2K21.15692424
51CSNK1G11.14955449
52SGK21.12983171
53CAMKK21.10378847
54PIK3CG1.09041191
55NLK1.08298296
56NEK61.07496695
57SYK1.07364842
58ATR1.06312327
59DAPK11.02831055
60IKBKB1.01078223
61RET0.99255176
62PASK0.99173310
63TGFBR10.98829610
64CDK70.98278184
65SIK30.94598988
66DYRK1A0.94370420
67IRAK20.93832697
68JAK30.93294678
69YES10.91714389
70BMPR1B0.88437285
71MAPKAPK50.87254641
72TAF10.87006431
73MAP3K110.84853117
74CDK30.84660012
75EIF2AK20.83497375
76CAMK10.83249358
77BMX0.79760578
78MYLK0.76243817
79LYN0.74515229
80BMPR20.71943984
81MATK0.71570315
82SGK4940.70527278
83SGK2230.70527278
84CSF1R0.70260521
85GRK70.70128455
86CDK80.69398892
87MKNK20.69008206
88TAOK20.68655828
89ZAP700.68059776
90MAP3K130.67817544
91EPHA30.66140214
92KDR0.64528398
93PIM20.62624056
94INSRR0.60839663
95WNK30.60788030
96RPS6KL10.60380249
97RPS6KC10.60380249
98CLK10.59931753
99TLK10.59823462
100RPS6KA50.59794254
101PLK20.59646784
102MAP3K140.59269726
103FRK0.58923903
104BRSK10.58133384
105MAP2K30.57740840
106GSK3A0.57377196
107MAP2K60.57343003
108SGK30.56740588
109CDC70.53767126
110AKT30.53378445
111MAP3K50.53376906
112STK240.52817275
113RPS6KA40.51185122
114MAP3K40.51037492
115UHMK10.50237367
116FES0.49225482
117CDK40.49217661
118VRK20.48300105
119LCK0.47673531
120HCK0.46942296
121RIPK40.46543056
122BCKDK0.46537620
123PLK30.46187408
124TAOK30.46089960
125RPS6KB20.44937456
126ADRBK10.44764411
127DAPK20.42994231
128STK38L0.42557562
129PRKCH0.42316889
130PLK10.42145543
131PAK20.42059281
132CSNK2A10.41823113
133MAPK40.40886593
134CSNK1G30.40275817
135RPS6KA60.39475759
136CSNK2A20.38604541
137PRKG20.37037903
138HIPK20.36917759
139TYK20.36845327
140NEK90.36607912
141GRK60.36361845
142MAPK130.36274258
143PIM10.34964145
144OBSCN0.32666911
145PRKCD0.28844493
146PKN10.28744347
147MAPK30.27042718
148FER0.26607196
149ITK0.26211382
150DYRK20.26142457
151PRKCA0.24342839
152AURKA0.23963959
153PTK2B0.23849618
154AKT10.23238998

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15186051
2Ribosome_Homo sapiens_hsa030104.03155191
3RNA polymerase_Homo sapiens_hsa030203.82821098
4Mismatch repair_Homo sapiens_hsa034303.50702626
5Pyrimidine metabolism_Homo sapiens_hsa002402.93813547
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.88484303
7Proteasome_Homo sapiens_hsa030502.78245269
8Ether lipid metabolism_Homo sapiens_hsa005652.59591586
9Protein export_Homo sapiens_hsa030602.57619907
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55256925
11Base excision repair_Homo sapiens_hsa034102.50333884
12Linoleic acid metabolism_Homo sapiens_hsa005912.48991892
13Fanconi anemia pathway_Homo sapiens_hsa034602.42686901
14Homologous recombination_Homo sapiens_hsa034402.40489840
15Peroxisome_Homo sapiens_hsa041462.38285271
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.34968572
17Basal cell carcinoma_Homo sapiens_hsa052172.32974574
18Spliceosome_Homo sapiens_hsa030402.28125990
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22722668
20Nucleotide excision repair_Homo sapiens_hsa034202.18856218
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18371068
22SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14963967
23Purine metabolism_Homo sapiens_hsa002302.01833736
24RNA degradation_Homo sapiens_hsa030181.96301415
25Non-homologous end-joining_Homo sapiens_hsa034501.94483615
26Basal transcription factors_Homo sapiens_hsa030221.92733962
27Cocaine addiction_Homo sapiens_hsa050301.86592974
28Tryptophan metabolism_Homo sapiens_hsa003801.68346309
29Butanoate metabolism_Homo sapiens_hsa006501.58627255
30Renin secretion_Homo sapiens_hsa049241.53760723
31Retinol metabolism_Homo sapiens_hsa008301.49733868
32Insulin secretion_Homo sapiens_hsa049111.42253033
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37595563
34Hedgehog signaling pathway_Homo sapiens_hsa043401.37541028
35Primary immunodeficiency_Homo sapiens_hsa053401.37424394
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35694676
37ABC transporters_Homo sapiens_hsa020101.30408002
38Cell cycle_Homo sapiens_hsa041101.30215238
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29069116
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28078008
41RNA transport_Homo sapiens_hsa030131.23096060
42Propanoate metabolism_Homo sapiens_hsa006401.18736536
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16888249
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15249336
45Herpes simplex infection_Homo sapiens_hsa051681.14908755
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14438270
47Hematopoietic cell lineage_Homo sapiens_hsa046401.14110350
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.13118095
49Other glycan degradation_Homo sapiens_hsa005111.10919357
50Arachidonic acid metabolism_Homo sapiens_hsa005901.10767707
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09958883
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.08162270
53Measles_Homo sapiens_hsa051621.07268142
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06998584
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06454716
56Fatty acid elongation_Homo sapiens_hsa000621.06034656
57Amphetamine addiction_Homo sapiens_hsa050311.03778120
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.02215672
59Melanogenesis_Homo sapiens_hsa049161.02035952
60Allograft rejection_Homo sapiens_hsa053301.01876021
61Sulfur relay system_Homo sapiens_hsa041221.01029580
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00785590
63Regulation of autophagy_Homo sapiens_hsa041401.00110970
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00014197
65Chemical carcinogenesis_Homo sapiens_hsa052040.99818119
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94043713
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88073667
68Notch signaling pathway_Homo sapiens_hsa043300.87619591
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.85377975
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.85290444
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84969496
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84889616
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84752579
74Sphingolipid metabolism_Homo sapiens_hsa006000.83653007
75Histidine metabolism_Homo sapiens_hsa003400.83165348
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82167827
77Folate biosynthesis_Homo sapiens_hsa007900.80379288
78p53 signaling pathway_Homo sapiens_hsa041150.79802586
79Parkinsons disease_Homo sapiens_hsa050120.79610946
80N-Glycan biosynthesis_Homo sapiens_hsa005100.79521967
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79500840
82Type I diabetes mellitus_Homo sapiens_hsa049400.77875440
83Asthma_Homo sapiens_hsa053100.77489853
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76146410
85cAMP signaling pathway_Homo sapiens_hsa040240.75696548
86Leishmaniasis_Homo sapiens_hsa051400.75473579
87Pancreatic secretion_Homo sapiens_hsa049720.74921678
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.74013853
89Huntingtons disease_Homo sapiens_hsa050160.73659854
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.72239542
91Epstein-Barr virus infection_Homo sapiens_hsa051690.71301314
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70803458
93Salivary secretion_Homo sapiens_hsa049700.68802765
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.67627648
95Oxidative phosphorylation_Homo sapiens_hsa001900.63799247
96mRNA surveillance pathway_Homo sapiens_hsa030150.62758120
97Dopaminergic synapse_Homo sapiens_hsa047280.61158315
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60324835
99ECM-receptor interaction_Homo sapiens_hsa045120.59966907
100Cardiac muscle contraction_Homo sapiens_hsa042600.58026331
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57876965
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57837584
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57769522
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.57208730
105Protein digestion and absorption_Homo sapiens_hsa049740.56969738
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55513127
107Taste transduction_Homo sapiens_hsa047420.54678196
108Serotonergic synapse_Homo sapiens_hsa047260.54472493
109Antigen processing and presentation_Homo sapiens_hsa046120.54284297
110Legionellosis_Homo sapiens_hsa051340.53313841
111Glutathione metabolism_Homo sapiens_hsa004800.52733390
112Tyrosine metabolism_Homo sapiens_hsa003500.52177050
113Pertussis_Homo sapiens_hsa051330.51568233
114One carbon pool by folate_Homo sapiens_hsa006700.51279886
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50635729
116Oxytocin signaling pathway_Homo sapiens_hsa049210.49880010
117Glycerolipid metabolism_Homo sapiens_hsa005610.49708986
118Olfactory transduction_Homo sapiens_hsa047400.49489746
119Nitrogen metabolism_Homo sapiens_hsa009100.49423068
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49014054
121Staphylococcus aureus infection_Homo sapiens_hsa051500.48488974
122Arginine and proline metabolism_Homo sapiens_hsa003300.48257152
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46213991
124Morphine addiction_Homo sapiens_hsa050320.46211557
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45679062
126Fat digestion and absorption_Homo sapiens_hsa049750.44434676
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43302043
128Insulin resistance_Homo sapiens_hsa049310.43233187
129Platelet activation_Homo sapiens_hsa046110.43056393
130Circadian entrainment_Homo sapiens_hsa047130.41463972
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41186968
132Thyroid cancer_Homo sapiens_hsa052160.40931485
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40114518
134Circadian rhythm_Homo sapiens_hsa047100.39039146
135Influenza A_Homo sapiens_hsa051640.38814271
136Metabolic pathways_Homo sapiens_hsa011000.38373468
137Rheumatoid arthritis_Homo sapiens_hsa053230.34604815
138Phototransduction_Homo sapiens_hsa047440.33544948
139Nicotine addiction_Homo sapiens_hsa050330.33197009
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32850265
141Galactose metabolism_Homo sapiens_hsa000520.31464253
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.30302739
143Shigellosis_Homo sapiens_hsa051310.28830811
144Alzheimers disease_Homo sapiens_hsa050100.28652299
145Pentose phosphate pathway_Homo sapiens_hsa000300.27733450
146Graft-versus-host disease_Homo sapiens_hsa053320.27203365
147Autoimmune thyroid disease_Homo sapiens_hsa053200.27195303
148Hepatitis B_Homo sapiens_hsa051610.26139743
149Ovarian steroidogenesis_Homo sapiens_hsa049130.25739371
150Calcium signaling pathway_Homo sapiens_hsa040200.24957630
151Vitamin digestion and absorption_Homo sapiens_hsa049770.23428384
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21778530
153Alcoholism_Homo sapiens_hsa050340.20389045
154Acute myeloid leukemia_Homo sapiens_hsa052210.19575376
155Oocyte meiosis_Homo sapiens_hsa041140.19530048
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19351312
157HTLV-I infection_Homo sapiens_hsa051660.19177369
158Caffeine metabolism_Homo sapiens_hsa002320.19050226

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