EFEMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.51693463
2collagen fibril organization (GO:0030199)5.40075354
3chondrocyte proliferation (GO:0035988)5.09314471
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.80471949
5negative regulation of fatty acid transport (GO:2000192)4.74704211
6protein heterotrimerization (GO:0070208)4.58430886
7cellular glucuronidation (GO:0052695)4.32627488
8substrate-dependent cell migration (GO:0006929)4.28494213
9glucuronate metabolic process (GO:0019585)4.17286978
10uronic acid metabolic process (GO:0006063)4.17286978
11kidney mesenchyme development (GO:0072074)4.16174948
12regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.10658328
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.07888766
14low-density lipoprotein particle clearance (GO:0034383)3.98127250
15cell migration involved in heart development (GO:0060973)3.91256935
16sequestering of extracellular ligand from receptor (GO:0035581)3.87836875
17mesenchymal-epithelial cell signaling (GO:0060638)3.86505304
18positive regulation of blood vessel endothelial cell migration (GO:0043536)3.84871805
19regulation of plasminogen activation (GO:0010755)3.79079720
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.76842283
21axon extension involved in axon guidance (GO:0048846)3.76842283
22xenobiotic catabolic process (GO:0042178)3.75298905
23peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.74387143
24epoxygenase P450 pathway (GO:0019373)3.73504731
25positive regulation of endothelial cell apoptotic process (GO:2000353)3.73482564
26artery development (GO:0060840)3.73345410
27negative regulation of adherens junction organization (GO:1903392)3.70887138
28negative regulation of focal adhesion assembly (GO:0051895)3.70887138
29negative regulation of cell junction assembly (GO:1901889)3.70887138
30positive regulation of endothelial cell differentiation (GO:0045603)3.68508763
31venous blood vessel morphogenesis (GO:0048845)3.64286247
32sprouting angiogenesis (GO:0002040)3.57568705
33negative regulation of blood vessel endothelial cell migration (GO:0043537)3.55715623
34positive regulation of cartilage development (GO:0061036)3.53258123
35apoptotic cell clearance (GO:0043277)3.51836648
36metanephric mesenchyme development (GO:0072075)3.50446425
37regulation of chemokine-mediated signaling pathway (GO:0070099)3.47895629
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.46941766
39lymph vessel development (GO:0001945)3.46408233
40positive regulation of fibroblast migration (GO:0010763)3.44091017
41positive regulation of endothelial cell migration (GO:0010595)3.41796322
42endodermal cell differentiation (GO:0035987)3.40319797
43vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.39562215
44basement membrane organization (GO:0071711)3.38637161
45glomerular basement membrane development (GO:0032836)3.38369956
46collagen metabolic process (GO:0032963)3.36346510
47positive regulation of extracellular matrix organization (GO:1903055)3.34811302
48hyaluronan catabolic process (GO:0030214)3.34644559
49positive regulation of receptor recycling (GO:0001921)3.33585429
50regulation of tight junction assembly (GO:2000810)3.33453642
51regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.33063748
52G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30928228
53negative regulation of nitric-oxide synthase activity (GO:0051001)3.29491865
54positive regulation of fatty acid beta-oxidation (GO:0032000)3.29374566
55glomerular filtration (GO:0003094)3.28133378
56negative regulation of endothelial cell proliferation (GO:0001937)3.26854254
57multicellular organismal macromolecule metabolic process (GO:0044259)3.23855594
58collagen catabolic process (GO:0030574)3.18958208
59regulation of glomerular filtration (GO:0003093)3.18453876
60cell-substrate junction assembly (GO:0007044)3.17502314
61positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.15784269
62outer ear morphogenesis (GO:0042473)3.15126348
63multicellular organismal metabolic process (GO:0044236)3.15063267
64bone trabecula formation (GO:0060346)3.13827388
65regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.12426615
66regulation of blood vessel endothelial cell migration (GO:0043535)3.11935315
67lymphangiogenesis (GO:0001946)3.11159740
68regulation of integrin-mediated signaling pathway (GO:2001044)3.08539773
69positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.07176808
70extracellular matrix assembly (GO:0085029)3.06670002
71positive regulation of epithelial cell migration (GO:0010634)3.06183713
72extracellular matrix disassembly (GO:0022617)3.05951565
73positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.04929464
74blood vessel remodeling (GO:0001974)3.04575376
75positive regulation of gastrulation (GO:2000543)3.04387040
76skin morphogenesis (GO:0043589)3.04294811
77keratan sulfate catabolic process (GO:0042340)3.03712423
78endothelial cell morphogenesis (GO:0001886)3.03173433
79endothelial tube morphogenesis (GO:0061154)3.01377429
80morphogenesis of an endothelium (GO:0003159)3.01377429
81hemidesmosome assembly (GO:0031581)3.00845016
82regulation of transforming growth factor beta1 production (GO:0032908)3.00307682
83* negative regulation of chondrocyte differentiation (GO:0032331)2.98973675
84multicellular organismal catabolic process (GO:0044243)2.98613446
85regulation of skeletal muscle contraction (GO:0014819)2.96651901
86angiogenesis involved in wound healing (GO:0060055)2.95733956
87Golgi transport vesicle coating (GO:0048200)2.94538976
88COPI coating of Golgi vesicle (GO:0048205)2.94538976
89protein retention in ER lumen (GO:0006621)2.93887998
90induction of positive chemotaxis (GO:0050930)2.93528412
91membrane raft organization (GO:0031579)2.93482087
92cell migration involved in sprouting angiogenesis (GO:0002042)2.91968587
93endothelial cell proliferation (GO:0001935)2.90522284
94hippo signaling (GO:0035329)2.90226973
95neuron remodeling (GO:0016322)2.90173384
96positive regulation of urine volume (GO:0035810)2.89837944
97regulation of endothelial cell differentiation (GO:0045601)2.89146244
98positive regulation of odontogenesis (GO:0042482)2.87507063
99endocardial cushion development (GO:0003197)2.86985460
100cell proliferation involved in metanephros development (GO:0072203)2.86227774
101atrioventricular valve morphogenesis (GO:0003181)2.84077212
102positive regulation of osteoblast proliferation (GO:0033690)2.82791883
103positive regulation of fatty acid oxidation (GO:0046321)2.82167323
104response to magnesium ion (GO:0032026)2.81720510
105peptidyl-proline hydroxylation (GO:0019511)2.81049408
106* regulation of chondrocyte differentiation (GO:0032330)2.80747478
107negative regulation of complement activation (GO:0045916)2.79434020
108wound healing, spreading of cells (GO:0044319)2.78702732
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78536264
110dermatan sulfate biosynthetic process (GO:0030208)2.78429332
111L-ascorbic acid metabolic process (GO:0019852)2.77062860
112cell adhesion mediated by integrin (GO:0033627)2.76800315
113substrate adhesion-dependent cell spreading (GO:0034446)2.76024515
114regulation of endothelial cell migration (GO:0010594)2.75551229
115positive regulation of cardiac muscle hypertrophy (GO:0010613)2.75120516
116positive regulation of muscle hypertrophy (GO:0014742)2.75120516
117cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.74621583
118blood vessel endothelial cell migration (GO:0043534)2.73727300
119negative regulation of endothelial cell migration (GO:0010596)2.73610019
120negative regulation of cell-matrix adhesion (GO:0001953)2.73541830
121positive regulation of chondrocyte differentiation (GO:0032332)2.73137506
122white fat cell differentiation (GO:0050872)2.72680179
123ovulation cycle (GO:0042698)2.71494591
124pattern specification involved in kidney development (GO:0061004)2.69568931
125craniofacial suture morphogenesis (GO:0097094)2.69180430
126vascular endothelial growth factor signaling pathway (GO:0038084)2.68097251
127epithelial cell-cell adhesion (GO:0090136)2.67304720
128wound healing, spreading of epidermal cells (GO:0035313)2.65820627
129regulation of phospholipase A2 activity (GO:0032429)2.65778719
130* regulation of cartilage development (GO:0061035)2.64416482
131regulation of gastrulation (GO:0010470)2.63527846
132omega-hydroxylase P450 pathway (GO:0097267)2.63213783
133embryonic cranial skeleton morphogenesis (GO:0048701)2.62755134
134positive regulation of p38MAPK cascade (GO:1900745)2.61047282
135cellular response to interferon-alpha (GO:0035457)2.60808884
136branching involved in salivary gland morphogenesis (GO:0060445)2.60533531
137protein localization to cell surface (GO:0034394)2.60491852
138negative regulation of leukocyte chemotaxis (GO:0002689)2.60272677
139middle ear morphogenesis (GO:0042474)2.59888318
140negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.59595381
141* extracellular matrix organization (GO:0030198)2.59197236
142protein targeting to plasma membrane (GO:0072661)2.58810827
143* extracellular structure organization (GO:0043062)2.57865616
144phagocytosis, recognition (GO:0006910)2.56306450
145extracellular fibril organization (GO:0043206)2.55312582
146renal filtration (GO:0097205)2.53343806
147blood vessel maturation (GO:0001955)2.53037243
148dermatan sulfate metabolic process (GO:0030205)2.52957927
149type B pancreatic cell proliferation (GO:0044342)2.52135767
150mesenchyme morphogenesis (GO:0072132)2.51369188
151fibril organization (GO:0097435)2.51171136
152muscle cell migration (GO:0014812)2.51058953
153* negative regulation of cartilage development (GO:0061037)2.49927208
154negative regulation of catenin import into nucleus (GO:0035414)2.48900517
155plasma membrane repair (GO:0001778)2.46890880
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45404210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human5.65403902
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.29031042
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.13461523
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.67899207
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35715569
6CLOCK_20551151_ChIP-Seq_293T_Human4.02215394
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17166754
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.87613370
9* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.46191022
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42476658
11NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.38242346
12NRF2_20460467_ChIP-Seq_MEFs_Mouse2.38242346
13* CJUN_26792858_Chip-Seq_BT549_Human2.38203250
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35096660
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33500177
16* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.29018808
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24190505
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22051121
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09915185
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.07811222
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03851665
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.96682219
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92267966
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87184996
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.82580537
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.81041196
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.80982990
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.77645022
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77378034
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77378034
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72866856
32TP53_18474530_ChIP-ChIP_U2OS_Human1.66485934
33SOX2_20726797_ChIP-Seq_SW620_Human1.65869504
34* BRD4_25478319_ChIP-Seq_HGPS_Human1.64456031
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.58539620
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57110329
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54467286
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53961218
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53839575
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47319577
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47178373
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.47132831
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.45475209
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38718692
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37996247
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37335631
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.34539097
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.32954993
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28553989
50TP53_16413492_ChIP-PET_HCT116_Human1.27774104
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.27159327
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26743321
53ZNF263_19887448_ChIP-Seq_K562_Human1.25879479
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24930472
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21514772
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20904496
57SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20107165
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18059999
59SA1_22415368_ChIP-Seq_MEFs_Mouse1.17080624
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.17052593
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16278400
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.15706687
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13486545
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11966913
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11741775
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10777608
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.10641331
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.10641331
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10202676
70* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09878828
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09511205
72* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09494123
73* GATA2_21666600_ChIP-Seq_HMVEC_Human1.09388751
74* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.09187363
75SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09186834
76* AHR_22903824_ChIP-Seq_MCF-7_Human1.08634533
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08471870
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07363363
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07315444
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07001905
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06239510
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05932626
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05767539
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05767539
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05697660
86ATF3_27146783_Chip-Seq_COLON_Human1.04146165
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03587982
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02848630
89RACK7_27058665_Chip-Seq_MCF-7_Human1.02823091
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01635453
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00944381
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00707693
93KLF5_25053715_ChIP-Seq_YYC3_Human1.00690000
94* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99545236
95TP53_22127205_ChIP-Seq_IMR90_Human0.99425284
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98669278
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98325046
98RXR_22108803_ChIP-Seq_LS180_Human0.98266296
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96952446
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96623030
101* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95024108
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94557440
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.94041320
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93927860
105* TP63_23658742_ChIP-Seq_EP156T_Human0.92680776
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90737183
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.90714232
108* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90493591
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90428781
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.90245709
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89287532
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.89154323
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88980770
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.88052614
115GATA4_25053715_ChIP-Seq_YYC3_Human0.85526790
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.84605066
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84505092
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.83146061
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82994951
120NFI_21473784_ChIP-Seq_ESCs_Mouse0.82815721
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82122968
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81520049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.21813198
2MP0005275_abnormal_skin_tensile5.15026820
3MP0003705_abnormal_hypodermis_morpholog4.98660730
4MP0005503_abnormal_tendon_morphology4.17071188
5MP0001958_emphysema4.00575480
6MP0003279_aneurysm3.64610232
7MP0009384_cardiac_valve_regurgitation3.60906730
8MP0002254_reproductive_system_inflammat2.97948704
9MP0004272_abnormal_basement_membrane2.84845347
10MP0002295_abnormal_pulmonary_circulatio2.20227676
11MP0010030_abnormal_orbit_morphology2.12047680
12MP0002060_abnormal_skin_morphology2.05424500
13MP0003941_abnormal_skin_development2.04055588
14MP0010368_abnormal_lymphatic_system1.98360038
15MP0005167_abnormal_blood-brain_barrier1.96774538
16MP0005623_abnormal_meninges_morphology1.94673183
17MP0005023_abnormal_wound_healing1.90839358
18MP0005508_abnormal_skeleton_morphology1.81920166
19MP0002877_abnormal_melanocyte_morpholog1.68652394
20MP0009250_abnormal_appendicular_skeleto1.58618018
21MP0001542_abnormal_bone_strength1.57103714
22MP0003566_abnormal_cell_adhesion1.54758450
23MP0000465_gastrointestinal_hemorrhage1.52982293
24MP0001879_abnormal_lymphatic_vessel1.47247940
25MP0006054_spinal_hemorrhage1.46168796
26MP0000534_abnormal_ureter_morphology1.45969792
27MP0003091_abnormal_cell_migration1.45529983
28MP0002108_abnormal_muscle_morphology1.44777330
29* MP0003385_abnormal_body_wall1.42412986
30MP0003950_abnormal_plasma_membrane1.37654349
31* MP0002168_other_aberrant_phenotype1.37280088
32MP0000013_abnormal_adipose_tissue1.35963312
33MP0009053_abnormal_anal_canal1.31196704
34MP0001346_abnormal_lacrimal_gland1.24629659
35MP0005388_respiratory_system_phenotype1.24285852
36MP0002133_abnormal_respiratory_system1.24285852
37MP0005670_abnormal_white_adipose1.23385304
38MP0003942_abnormal_urinary_system1.23111978
39MP0001915_intracranial_hemorrhage1.22804867
40MP0001849_ear_inflammation1.22452540
41MP0002896_abnormal_bone_mineralization1.22411134
42MP0000767_abnormal_smooth_muscle1.21226045
43MP0005164_abnormal_response_to1.20615284
44MP0000762_abnormal_tongue_morphology1.19929458
45MP0001348_abnormal_lacrimal_gland1.15363847
46MP0009780_abnormal_chondrocyte_physiolo1.12813429
47MP0010352_gastrointestinal_tract_polyps1.10176329
48MP0005390_skeleton_phenotype1.10074573
49MP0003191_abnormal_cellular_cholesterol1.09305260
50MP0001299_abnormal_eye_distance/1.08603340
51MP0003828_pulmonary_edema1.08233481
52MP0000163_abnormal_cartilage_morphology1.06271472
53MP0001177_atelectasis1.05701430
54MP0005257_abnormal_intraocular_pressure1.04702541
55MP0000428_abnormal_craniofacial_morphol1.04273585
56MP0005595_abnormal_vascular_smooth1.03247170
57MP0000733_abnormal_muscle_development1.02651371
58MP0000343_altered_response_to1.02122302
59MP0004883_abnormal_blood_vessel1.01424432
60MP0005165_increased_susceptibility_to0.98930125
61MP0003186_abnormal_redox_activity0.98505234
62MP0002796_impaired_skin_barrier0.98426163
63MP0003806_abnormal_nucleotide_metabolis0.98366230
64MP0000751_myopathy0.97788479
65MP0003045_fibrosis0.97037136
66MP0002115_abnormal_skeleton_extremities0.95047654
67MP0005409_darkened_coat_color0.94508450
68MP0001243_abnormal_dermal_layer0.94111724
69MP0002925_abnormal_cardiovascular_devel0.91276284
70MP0001533_abnormal_skeleton_physiology0.89095082
71MP0004858_abnormal_nervous_system0.87618364
72MP0000249_abnormal_blood_vessel0.87402139
73MP0002282_abnormal_trachea_morphology0.85756246
74MP0003300_gastrointestinal_ulcer0.84789482
75MP0009115_abnormal_fat_cell0.83943268
76MP0005666_abnormal_adipose_tissue0.83403515
77MP0003115_abnormal_respiratory_system0.81336988
78MP0002932_abnormal_joint_morphology0.80976134
79MP0003935_abnormal_craniofacial_develop0.80860773
80MP0000750_abnormal_muscle_regeneration0.80768782
81MP0008007_abnormal_cellular_replicative0.80654538
82MP0003448_altered_tumor_morphology0.80334383
83MP0000003_abnormal_adipose_tissue0.80224050
84MP0000467_abnormal_esophagus_morphology0.80011496
85MP0000678_abnormal_parathyroid_gland0.79909110
86MP0000049_abnormal_middle_ear0.79482999
87MP0002249_abnormal_larynx_morphology0.79252296
88MP0002933_joint_inflammation0.78838382
89MP0004084_abnormal_cardiac_muscle0.78835419
90MP0005375_adipose_tissue_phenotype0.78691222
91MP0003724_increased_susceptibility_to0.78468556
92MP0001661_extended_life_span0.78215849
93MP0003755_abnormal_palate_morphology0.74953351
94MP0002128_abnormal_blood_circulation0.74901974
95* MP0005197_abnormal_uvea_morphology0.74840758
96MP0001270_distended_abdomen0.73676220
97MP0005171_absent_coat_pigmentation0.73198765
98MP0003868_abnormal_feces_composition0.73118769
99MP0002127_abnormal_cardiovascular_syste0.71717161
100MP0002998_abnormal_bone_remodeling0.70364156
101MP0003937_abnormal_limbs/digits/tail_de0.70112106
102MP0008004_abnormal_stomach_pH0.69931308
103MP0004130_abnormal_muscle_cell0.69739069
104MP0005193_abnormal_anterior_eye0.69368904
105MP0002113_abnormal_skeleton_development0.69334918
106MP0004185_abnormal_adipocyte_glucose0.68910011
107* MP0001614_abnormal_blood_vessel0.68798640
108MP0009379_abnormal_foot_pigmentation0.68292992
109MP0004782_abnormal_surfactant_physiolog0.67028968
110MP0005248_abnormal_Harderian_gland0.65541671
111MP0002233_abnormal_nose_morphology0.64561760
112MP0001175_abnormal_lung_morphology0.64294664
113MP0000538_abnormal_urinary_bladder0.63385175
114MP0006138_congestive_heart_failure0.62855084
115MP0002090_abnormal_vision0.59688362
116MP0000462_abnormal_digestive_system0.57961678
117MP0000858_altered_metastatic_potential0.57735254
118MP0003453_abnormal_keratinocyte_physiol0.55947296
119MP0009278_abnormal_bone_marrow0.55612961
120MP0000537_abnormal_urethra_morphology0.54968560
121MP0004134_abnormal_chest_morphology0.54347067
122MP0000749_muscle_degeneration0.54311052
123* MP0000759_abnormal_skeletal_muscle0.54145185
124MP0002177_abnormal_outer_ear0.54120644
125MP0002697_abnormal_eye_size0.54035300
126MP0000432_abnormal_head_morphology0.53300597
127MP0000613_abnormal_salivary_gland0.53217749
128MP0000266_abnormal_heart_morphology0.52918783
129MP0002138_abnormal_hepatobiliary_system0.52746213
130MP0005501_abnormal_skin_physiology0.52271753
131MP0004484_altered_response_of0.51774392
132MP0003075_altered_response_to0.50968871

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.03377157
2Premature rupture of membranes (HP:0001788)6.49449317
3Aortic aneurysm (HP:0004942)5.14020082
4Broad metatarsal (HP:0001783)4.64722644
5Soft skin (HP:0000977)4.44293020
6Shallow orbits (HP:0000586)4.32279876
7Vascular tortuosity (HP:0004948)4.27535521
8Aortic dissection (HP:0002647)4.17281007
9Wrist flexion contracture (HP:0001239)4.12727960
10Ankle contracture (HP:0006466)4.06707458
11Dilatation of the ascending aorta (HP:0005111)3.88806592
12Arterial tortuosity (HP:0005116)3.80679666
13Atrophic scars (HP:0001075)3.73707653
14Bladder diverticulum (HP:0000015)3.68226681
15Cervical subluxation (HP:0003308)3.63710555
16Peritonitis (HP:0002586)3.61338445
17Wormian bones (HP:0002645)3.58617901
18Fragile skin (HP:0001030)3.53094496
19Follicular hyperkeratosis (HP:0007502)3.51342683
20Increased connective tissue (HP:0009025)3.41664996
21Spinal rigidity (HP:0003306)3.30701272
22Vertebral compression fractures (HP:0002953)3.20673344
23Aortic valve stenosis (HP:0001650)3.12797089
24Cerebral aneurysm (HP:0004944)3.11706728
25Abnormality of dentin (HP:0010299)3.09640835
26Hematochezia (HP:0002573)3.06541378
27Aplasia involving bones of the upper limbs (HP:0009823)2.97015064
28Aplasia of the phalanges of the hand (HP:0009802)2.97015064
29Aplasia involving bones of the extremities (HP:0009825)2.97015064
30Spontaneous hematomas (HP:0007420)2.86918642
31Type 1 muscle fiber predominance (HP:0003803)2.86364107
32Overgrowth (HP:0001548)2.85269281
33Neonatal short-limb short stature (HP:0008921)2.82925892
34Polycythemia (HP:0001901)2.78396776
35Biconcave vertebral bodies (HP:0004586)2.77421800
36Blue sclerae (HP:0000592)2.77250875
37Mitral valve prolapse (HP:0001634)2.74567075
38Short nail (HP:0001799)2.70325480
39Osteolytic defects of the hand bones (HP:0009699)2.66504396
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.66504396
41Esophageal varix (HP:0002040)2.65258912
42Conjunctival telangiectasia (HP:0000524)2.62985809
43Camptodactyly of toe (HP:0001836)2.57796649
44Nonimmune hydrops fetalis (HP:0001790)2.49309036
45Spinal cord lesions (HP:0100561)2.46510709
46Syringomyelia (HP:0003396)2.46510709
47Aneurysm (HP:0002617)2.45622955
48Bowel diverticulosis (HP:0005222)2.43704457
49Hyperextensible skin (HP:0000974)2.43151925
50Aortic regurgitation (HP:0001659)2.42757846
51Right ventricular cardiomyopathy (HP:0011663)2.38341051
52Mitral stenosis (HP:0001718)2.33556340
53Mesomelia (HP:0003027)2.27043385
54Wide anterior fontanel (HP:0000260)2.26309159
55Elbow flexion contracture (HP:0002987)2.26261886
56Hypoplasia of the iris (HP:0007676)2.25874745
57Coronal craniosynostosis (HP:0004440)2.21677339
58Buphthalmos (HP:0000557)2.21419081
59Acanthosis nigricans (HP:0000956)2.20868544
60Genu recurvatum (HP:0002816)2.20355476
61Spondylolisthesis (HP:0003302)2.18443255
62Tarsal synostosis (HP:0008368)2.17504309
63Venous insufficiency (HP:0005293)2.16024314
64Coxa vara (HP:0002812)2.14170124
65Short hallux (HP:0010109)2.12446462
66Abnormality of the acetabulum (HP:0003170)2.10997147
67Disproportionate tall stature (HP:0001519)2.10726582
68Bronchomalacia (HP:0002780)2.10049745
69Ovoid vertebral bodies (HP:0003300)2.09816526
70Knee flexion contracture (HP:0006380)2.08400813
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07983277
72Abnormal hemoglobin (HP:0011902)2.06844387
73Reduced subcutaneous adipose tissue (HP:0003758)2.05202008
74Abnormal delivery (HP:0001787)2.05138873
75Abnormality of the nasal mucosa (HP:0000433)2.04608521
76Trismus (HP:0000211)2.02799908
77Joint laxity (HP:0001388)2.02595114
78Deviation of the hallux (HP:0010051)2.02352316
79Cardiovascular calcification (HP:0011915)2.01588460
80Ectopia lentis (HP:0001083)2.01552538
81Mildly elevated creatine phosphokinase (HP:0008180)2.01398587
82Bell-shaped thorax (HP:0001591)2.00333528
83Spinal cord compression (HP:0002176)1.98246582
84Abnormality of the distal phalanges of the toes (HP:0010182)1.95339276
85Cerebral hemorrhage (HP:0001342)1.93817163
86Thin bony cortex (HP:0002753)1.93392417
87Alopecia of scalp (HP:0002293)1.93122067
88Aplasia/Hypoplasia of the hallux (HP:0008362)1.92999662
89Increased variability in muscle fiber diameter (HP:0003557)1.91738991
90Mitral regurgitation (HP:0001653)1.91658642
91Slender build (HP:0001533)1.91251386
92Ulnar bowing (HP:0003031)1.91239785
93Hallux valgus (HP:0001822)1.89870987
94Turricephaly (HP:0000262)1.89780027
95Neonatal death (HP:0003811)1.89752203
96Broad face (HP:0000283)1.89417588
97Asymmetry of the thorax (HP:0001555)1.89160458
98Infantile muscular hypotonia (HP:0008947)1.89157022
99Joint stiffness (HP:0001387)1.89083428
100Limited hip movement (HP:0008800)1.88689877
101Synostosis involving bones of the lower limbs (HP:0009138)1.87371705
102Synostosis involving bones of the feet (HP:0009140)1.87371705
103Joint contractures involving the joints of the feet (HP:0100492)1.86528430
104Flexion contracture of toe (HP:0005830)1.86528430
105Hip contracture (HP:0003273)1.85793175
106Abnormal cartilage morphology (HP:0002763)1.81609761
107Distal lower limb muscle weakness (HP:0009053)1.81532131
108Broad hallux (HP:0010055)1.81495174
109Round ear (HP:0100830)1.81376395
110Beaking of vertebral bodies (HP:0004568)1.81060707
111Abnormality of the anterior chamber (HP:0000593)1.80547739
112Fragile nails (HP:0001808)1.80545845
113Congenital glaucoma (HP:0001087)1.80349260
114Inguinal hernia (HP:0000023)1.80252805
115Fibular aplasia (HP:0002990)1.80241851
116Broad toe (HP:0001837)1.79773343
117Skull defect (HP:0001362)1.78699902
118Mucopolysacchariduria (HP:0008155)1.78600596
119Urinary glycosaminoglycan excretion (HP:0003541)1.78600596
120Abnormality of the 2nd finger (HP:0004100)1.78040962
121Bowed forearm bones (HP:0003956)1.76478609
122Bowing of the arm (HP:0006488)1.76478609
123Natal tooth (HP:0000695)1.76256702
124Abnormal vertebral ossification (HP:0100569)1.75820618
125Striae distensae (HP:0001065)1.74638425
126Vertebral clefting (HP:0008428)1.74279017
127Broad ribs (HP:0000885)1.73781875
128Venous abnormality (HP:0002624)1.72848310
129Protruding ear (HP:0000411)1.72435650
130Osteopenia (HP:0000938)1.71851538
131Rectal prolapse (HP:0002035)1.70817228
132Abnormality of the intrinsic pathway (HP:0010989)1.70350019
133Menorrhagia (HP:0000132)1.70276581
134Delayed cranial suture closure (HP:0000270)1.68421159
135Pulmonary hypertension (HP:0002092)1.68032315
136Bradycardia (HP:0001662)1.68011513
137Flat cornea (HP:0007720)1.67792512
138Lymphangioma (HP:0100764)1.67357491
139Osteoarthritis (HP:0002758)1.66460612
140Abnormality of skeletal muscle fiber size (HP:0012084)1.66252166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.51180012
2ERN14.02292943
3TRIB33.25120204
4TTN2.90692646
5EPHB22.84485368
6ERBB32.74211376
7LATS22.72449950
8PDGFRA2.57740895
9LATS12.43527827
10SIK12.23432569
11TESK12.04131761
12TRPM72.01779018
13FER2.01318774
14PAK21.95351613
15TGFBR11.94251315
16NEK91.86535797
17KDR1.76484473
18MAP3K31.72705423
19CAMK1D1.71444148
20RIPK11.69221038
21PIM21.65810935
22LIMK11.65772302
23FRK1.59852646
24TGFBR21.54968995
25MST1R1.50206834
26MOS1.45171219
27PTK21.42604608
28PAK31.40526333
29PAK41.38375951
30MYLK1.37125433
31FLT31.32828807
32MET1.31174174
33PKN21.28083282
34PTK61.26754653
35PTK2B1.26401795
36RPS6KA41.25752273
37LRRK21.23676678
38BMX1.22809521
39MAP2K11.22602409
40MAP3K121.21016901
41FES1.16241647
42LMTK21.15489184
43CDK61.07142553
44EPHA21.04485981
45BMPR1B1.04084782
46ROCK11.00838496
47BCKDK0.99676381
48STK30.99499769
49FGFR10.98599212
50CAMK1G0.98101403
51CDK80.96239413
52PIK3CA0.96162428
53PDK20.95175922
54PDGFRB0.92752421
55WNK10.85162825
56EPHA30.84402477
57EPHB10.83747680
58ILK0.81141081
59ROCK20.79621563
60FGFR20.78965922
61TAOK10.77353315
62MAPKAPK30.76960412
63STK380.76949407
64NME20.76494893
65PIK3CG0.74236036
66MAP2K20.72393226
67PAK60.70975374
68PRKD10.69825037
69MAP3K60.69633357
70RPS6KA20.69545955
71DMPK0.66598391
72ERBB40.65522501
73MTOR0.61724644
74NTRK10.61709182
75PDK40.61176284
76PDK30.61176284
77ZAK0.60709260
78DYRK1B0.60205080
79TAOK20.59994934
80GRK50.58482795
81MAP3K20.57936730
82EEF2K0.57920889
83ABL20.57535514
84MAPK70.55027028
85CDC42BPA0.54672300
86ZAP700.54504944
87PRKCH0.54089096
88SCYL20.52203134
89PRKD30.51936825
90SMG10.51727879
91TIE10.51564333
92IRAK30.50597084
93IGF1R0.47986944
94JAK30.47588309
95INSR0.47274372
96ARAF0.44878956
97MAPKAPK50.44652259
98MAP2K30.40478233
99SRC0.38378366
100PBK0.37484842
101GSK3A0.36712463
102PRKD20.36021195
103STK38L0.35982663
104DAPK30.35147487
105TEC0.34016824
106CAMK2G0.32091028
107CSK0.31278538
108NUAK10.30800362
109MAP3K70.30057098
110CAMKK10.29713845
111PRKCE0.29675181
112KSR20.29387701
113JAK10.29044243
114CDK90.28839412
115CLK10.28554564
116FGFR40.28480047
117PRKG20.28236513
118MAP3K110.28005996
119MAPKAPK20.27572287
120PAK10.27271625
121ABL10.26920230
122PLK20.26856732
123WNK40.26500930
124MELK0.25342609
125CAMK2B0.25211295
126MARK20.24054163
127EGFR0.23400283
128ADRBK10.23306105
129RET0.23059767
130PRKAA20.21102857
131FGFR30.19147102
132ICK0.18338245

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47161493
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.35424859
3ECM-receptor interaction_Homo sapiens_hsa045123.17610403
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.09919983
5Chemical carcinogenesis_Homo sapiens_hsa052043.07010348
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.72012874
7Focal adhesion_Homo sapiens_hsa045102.25933721
8Caffeine metabolism_Homo sapiens_hsa002321.99096799
9Proteoglycans in cancer_Homo sapiens_hsa052051.90457631
10Glutathione metabolism_Homo sapiens_hsa004801.87520095
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.84520983
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79968725
13Protein digestion and absorption_Homo sapiens_hsa049741.67584814
14Adherens junction_Homo sapiens_hsa045201.63502359
15TGF-beta signaling pathway_Homo sapiens_hsa043501.61622603
16Starch and sucrose metabolism_Homo sapiens_hsa005001.56575106
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55822533
18PPAR signaling pathway_Homo sapiens_hsa033201.54489349
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53522322
20Bladder cancer_Homo sapiens_hsa052191.49045743
21Malaria_Homo sapiens_hsa051441.45992097
22Nitrogen metabolism_Homo sapiens_hsa009101.45393988
23Retinol metabolism_Homo sapiens_hsa008301.44841442
24Other glycan degradation_Homo sapiens_hsa005111.42638422
25Hippo signaling pathway_Homo sapiens_hsa043901.41287020
26Fatty acid biosynthesis_Homo sapiens_hsa000611.38927365
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37473916
28Amoebiasis_Homo sapiens_hsa051461.35886811
29Phenylalanine metabolism_Homo sapiens_hsa003601.32999209
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28601466
31Fatty acid metabolism_Homo sapiens_hsa012121.22386074
32Sulfur metabolism_Homo sapiens_hsa009201.17992280
33Basal cell carcinoma_Homo sapiens_hsa052171.15356342
34Complement and coagulation cascades_Homo sapiens_hsa046101.09964716
35Melanoma_Homo sapiens_hsa052181.09623206
36Propanoate metabolism_Homo sapiens_hsa006401.08245227
37Small cell lung cancer_Homo sapiens_hsa052221.07746034
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05423862
39Dilated cardiomyopathy_Homo sapiens_hsa054141.03883900
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01955367
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00995177
42Fatty acid degradation_Homo sapiens_hsa000710.99898689
43N-Glycan biosynthesis_Homo sapiens_hsa005100.99714218
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.95315803
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.92501708
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92372266
47Pertussis_Homo sapiens_hsa051330.92029758
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91061001
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90839522
50Tight junction_Homo sapiens_hsa045300.90405688
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90314341
52Renin-angiotensin system_Homo sapiens_hsa046140.89389332
53Renal cell carcinoma_Homo sapiens_hsa052110.87685689
54Endocytosis_Homo sapiens_hsa041440.87469206
55MicroRNAs in cancer_Homo sapiens_hsa052060.85060741
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83686361
57Ras signaling pathway_Homo sapiens_hsa040140.82387546
58Phagosome_Homo sapiens_hsa041450.82058347
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81440425
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81170804
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79731451
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.78211437
63Vibrio cholerae infection_Homo sapiens_hsa051100.77852708
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.75056323
65beta-Alanine metabolism_Homo sapiens_hsa004100.74826378
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73255298
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73247234
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72940830
69Lysosome_Homo sapiens_hsa041420.72555177
70Galactose metabolism_Homo sapiens_hsa000520.70943743
71Viral myocarditis_Homo sapiens_hsa054160.70464194
72Hedgehog signaling pathway_Homo sapiens_hsa043400.70410774
73Prostate cancer_Homo sapiens_hsa052150.70388243
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.70082505
75Tyrosine metabolism_Homo sapiens_hsa003500.68880271
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68563187
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68513633
78HIF-1 signaling pathway_Homo sapiens_hsa040660.67080092
79Chronic myeloid leukemia_Homo sapiens_hsa052200.66944501
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66743221
81Salmonella infection_Homo sapiens_hsa051320.65259666
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.63906232
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63311101
84Rap1 signaling pathway_Homo sapiens_hsa040150.62242016
85Notch signaling pathway_Homo sapiens_hsa043300.61435530
86Pathways in cancer_Homo sapiens_hsa052000.60395355
87Axon guidance_Homo sapiens_hsa043600.59050248
88Thyroid cancer_Homo sapiens_hsa052160.58570376
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57345395
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56653921
91Sphingolipid metabolism_Homo sapiens_hsa006000.56484504
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55570859
93VEGF signaling pathway_Homo sapiens_hsa043700.52265047
94Thyroid hormone synthesis_Homo sapiens_hsa049180.51406748
95TNF signaling pathway_Homo sapiens_hsa046680.51377177
96Pentose phosphate pathway_Homo sapiens_hsa000300.50691260
97Insulin resistance_Homo sapiens_hsa049310.48983086
98Prion diseases_Homo sapiens_hsa050200.47892179
99GnRH signaling pathway_Homo sapiens_hsa049120.47229232
100p53 signaling pathway_Homo sapiens_hsa041150.46517908
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.46431200
102Estrogen signaling pathway_Homo sapiens_hsa049150.45734934
103Ovarian steroidogenesis_Homo sapiens_hsa049130.45420784
104AMPK signaling pathway_Homo sapiens_hsa041520.44477854
105Tryptophan metabolism_Homo sapiens_hsa003800.44250307
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.44063546
107Choline metabolism in cancer_Homo sapiens_hsa052310.43702283
108Mineral absorption_Homo sapiens_hsa049780.42293535
109mTOR signaling pathway_Homo sapiens_hsa041500.42270417
110Gap junction_Homo sapiens_hsa045400.40402768
111Platelet activation_Homo sapiens_hsa046110.39752647
112Steroid biosynthesis_Homo sapiens_hsa001000.39547842
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.39073165
114Pyruvate metabolism_Homo sapiens_hsa006200.38976877
115Glycerolipid metabolism_Homo sapiens_hsa005610.38492375
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.38265582
117Melanogenesis_Homo sapiens_hsa049160.38265446
118Fat digestion and absorption_Homo sapiens_hsa049750.38250941
119Pancreatic cancer_Homo sapiens_hsa052120.38149250
120MAPK signaling pathway_Homo sapiens_hsa040100.38090943
121Colorectal cancer_Homo sapiens_hsa052100.37553707
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37385110
123Wnt signaling pathway_Homo sapiens_hsa043100.36829048
124Shigellosis_Homo sapiens_hsa051310.36730936
125Arginine and proline metabolism_Homo sapiens_hsa003300.36710340
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36573285
127Apoptosis_Homo sapiens_hsa042100.36352549
128HTLV-I infection_Homo sapiens_hsa051660.35419842
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34699584
130Bile secretion_Homo sapiens_hsa049760.33973433
131Glioma_Homo sapiens_hsa052140.33858685
132Toxoplasmosis_Homo sapiens_hsa051450.33152157
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32506558
134Arginine biosynthesis_Homo sapiens_hsa002200.32303028
135African trypanosomiasis_Homo sapiens_hsa051430.29062964
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28677353

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