EFHC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains three DM10 domains and three calcium-binding EF-hand motifs. A related protein is encoded by a gene on chromosome 6. It has been suggested that both proteins are involved in the development of epilepsy (PMID: 15258581, 16112844) and that this gene may be associated with fear recognition in individuals with Turner syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.51860949
2synaptonemal complex assembly (GO:0007130)8.44955847
3male meiosis (GO:0007140)8.02954593
4synaptonemal complex organization (GO:0070193)7.91607413
5acrosome assembly (GO:0001675)7.50553476
6multicellular organism reproduction (GO:0032504)7.24898046
7cell wall macromolecule metabolic process (GO:0044036)6.93332349
8cell wall macromolecule catabolic process (GO:0016998)6.93332349
9cilium or flagellum-dependent cell motility (GO:0001539)6.70602858
10sperm-egg recognition (GO:0035036)6.67406707
11fusion of sperm to egg plasma membrane (GO:0007342)6.47282452
12thrombin receptor signaling pathway (GO:0070493)6.32437258
13axonemal dynein complex assembly (GO:0070286)6.30371128
14DNA methylation involved in gamete generation (GO:0043046)6.23402301
15protein neddylation (GO:0045116)6.21069642
16regulation of cilium movement (GO:0003352)6.10047145
17cell-cell recognition (GO:0009988)5.93813881
18chromosome organization involved in meiosis (GO:0070192)5.90505783
19binding of sperm to zona pellucida (GO:0007339)5.83051401
20cilium movement (GO:0003341)5.71605459
21sperm motility (GO:0030317)5.52691089
22epithelial cilium movement (GO:0003351)5.52641032
23reproduction (GO:0000003)5.47797330
24meiotic nuclear division (GO:0007126)5.40260881
25left/right pattern formation (GO:0060972)5.32218743
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.28695772
27neutrophil activation involved in immune response (GO:0002283)5.25153054
28protein polyglutamylation (GO:0018095)4.98945839
29plasma membrane fusion (GO:0045026)4.85995641
30spermatid development (GO:0007286)4.78223243
31microtubule severing (GO:0051013)4.71806706
32protein K6-linked ubiquitination (GO:0085020)4.66463482
33centriole replication (GO:0007099)4.64153839
34meiotic chromosome segregation (GO:0045132)4.50857568
35left/right axis specification (GO:0070986)4.44260421
36centriole assembly (GO:0098534)4.39551595
37single fertilization (GO:0007338)4.39234439
38male meiosis I (GO:0007141)4.29390600
39regulation of platelet aggregation (GO:0090330)4.29352075
40cilium organization (GO:0044782)4.28479566
41fertilization (GO:0009566)4.20590882
42motile cilium assembly (GO:0044458)4.17705428
43cilium assembly (GO:0042384)4.14981820
44regulation of meiosis I (GO:0060631)4.11332456
45meiotic cell cycle process (GO:1903046)4.05946007
46regulation of platelet activation (GO:0010543)4.01984078
47acrosome reaction (GO:0007340)3.96347471
48relaxation of smooth muscle (GO:0044557)3.93281185
49ventricular system development (GO:0021591)3.90956140
50nuclear pore complex assembly (GO:0051292)3.90933372
51regulation of microtubule-based movement (GO:0060632)3.90696161
52negative regulation of heart rate (GO:0010459)3.86808691
53sperm capacitation (GO:0048240)3.84812421
54microtubule depolymerization (GO:0007019)3.79686212
55negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.77350168
56negative regulation of norepinephrine secretion (GO:0010700)3.74980065
57negative regulation of thymocyte apoptotic process (GO:0070244)3.72838257
58gene silencing by RNA (GO:0031047)3.72747194
59adenosine receptor signaling pathway (GO:0001973)3.72305542
60nuclear pore organization (GO:0006999)3.70402474
61lipoxygenase pathway (GO:0019372)3.69775434
62regulation of integrin-mediated signaling pathway (GO:2001044)3.66229373
63spermatogenesis (GO:0007283)3.65660228
64male gamete generation (GO:0048232)3.65199184
65negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.61498027
66protein localization to cilium (GO:0061512)3.60586503
67intraciliary transport (GO:0042073)3.60085488
68histone exchange (GO:0043486)3.59762576
69negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.56317155
70meiosis I (GO:0007127)3.55681310
71gamete generation (GO:0007276)3.54781079
72monoubiquitinated protein deubiquitination (GO:0035520)3.52132850
73microtubule bundle formation (GO:0001578)3.50727646
74germ cell development (GO:0007281)3.46963301
75DNA replication-dependent nucleosome organization (GO:0034723)3.45616286
76DNA replication-dependent nucleosome assembly (GO:0006335)3.45616286
77G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.43919242
78aggressive behavior (GO:0002118)3.43273824
79regulation of germinal center formation (GO:0002634)3.40845372
80meiotic cell cycle (GO:0051321)3.39104401
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38469680
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38469680
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.38469680
84purinergic nucleotide receptor signaling pathway (GO:0035590)3.37459358
85tolerance induction (GO:0002507)3.37212643
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.35047539
87negative regulation of meiosis (GO:0045835)3.34817239
88blood coagulation, intrinsic pathway (GO:0007597)3.34280294
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32704875
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.32704875
91megakaryocyte development (GO:0035855)3.31298332
92cellular component assembly involved in morphogenesis (GO:0010927)3.29260673
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.29089563
94autophagic vacuole fusion (GO:0000046)3.27338081
95negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.27114075
96female gamete generation (GO:0007292)3.26879044
97chromatin remodeling at centromere (GO:0031055)3.26811415
98maturation of 5.8S rRNA (GO:0000460)3.25856257
99negative regulation of cell cycle G2/M phase transition (GO:1902750)3.25198357
100mitotic sister chromatid segregation (GO:0000070)3.20281880
101positive regulation of cAMP-mediated signaling (GO:0043950)3.19350812
102pore complex assembly (GO:0046931)3.19258945
103reciprocal DNA recombination (GO:0035825)3.18228901
104reciprocal meiotic recombination (GO:0007131)3.18228901
105oogenesis (GO:0048477)3.17765244
106spermatid nucleus differentiation (GO:0007289)3.17589836
107DNA alkylation (GO:0006305)3.17462318
108DNA methylation (GO:0006306)3.17462318
109neutrophil activation (GO:0042119)3.16693504
110positive regulation of endothelial cell differentiation (GO:0045603)3.16693456
111attachment of spindle microtubules to kinetochore (GO:0008608)3.16002416
112regulation of centriole replication (GO:0046599)3.15597383
113leukocyte migration involved in inflammatory response (GO:0002523)3.14758754
114synapsis (GO:0007129)3.14498515
115cilium morphogenesis (GO:0060271)3.13890565
116DNA replication checkpoint (GO:0000076)3.12107319
117cell projection assembly (GO:0030031)3.11578692
118regulation of female receptivity (GO:0045924)3.09894061
119positive regulation of mast cell activation (GO:0033005)3.06837518
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05902932
121negative regulation of appetite (GO:0032099)3.05677552
122negative regulation of response to food (GO:0032096)3.05677552
123triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.05521805
124negative regulation of homotypic cell-cell adhesion (GO:0034111)3.02009174
125negative regulation of chromosome segregation (GO:0051985)3.01227648
126axoneme assembly (GO:0035082)2.99247838
127mitotic chromosome condensation (GO:0007076)2.98598513
128definitive hemopoiesis (GO:0060216)2.98521190
129metaphase plate congression (GO:0051310)2.98507831
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98211895
131regulation of spindle checkpoint (GO:0090231)2.96828624
132microtubule polymerization or depolymerization (GO:0031109)2.95933523
133regulation of sister chromatid segregation (GO:0033045)2.95924504
134regulation of mitotic sister chromatid separation (GO:0010965)2.95924504
135regulation of mitotic sister chromatid segregation (GO:0033047)2.95924504
136regulation of Golgi to plasma membrane protein transport (GO:0042996)2.95266731
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95185103
138sister chromatid cohesion (GO:0007062)2.93625777
139CENP-A containing nucleosome assembly (GO:0034080)2.92845129
140resolution of meiotic recombination intermediates (GO:0000712)2.92331948
141regulation of chromosome segregation (GO:0051983)2.92286565
142mitotic metaphase plate congression (GO:0007080)2.91771138
143negative regulation of platelet activation (GO:0010544)2.91656581
144negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91642837
145negative regulation of T-helper cell differentiation (GO:0045623)2.91642837
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.90747117
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90747117
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90747117
149negative regulation of sister chromatid segregation (GO:0033046)2.90747117
150microtubule-based movement (GO:0007018)2.89600093
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89385930
152positive regulation of chromosome segregation (GO:0051984)2.87254579
153endothelium development (GO:0003158)2.84066196
154platelet aggregation (GO:0070527)2.83289869
155pyrimidine-containing compound transmembrane transport (GO:0072531)2.82035094
156angiogenesis involved in wound healing (GO:0060055)2.79960962
157organelle membrane fusion (GO:0090174)2.77521449
158platelet formation (GO:0030220)2.74499074
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73579687
160regulation of memory T cell differentiation (GO:0043380)2.73166904
161response to xenobiotic stimulus (GO:0009410)2.72484930
162negative regulation of stress fiber assembly (GO:0051497)2.69545519
163regulation of female gonad development (GO:2000194)2.69413361
164regulation of interleukin-13 production (GO:0032656)2.68326921
165regulation of MHC class II biosynthetic process (GO:0045346)2.65003345
166purinergic receptor signaling pathway (GO:0035587)2.64416436
167regulation of integrin activation (GO:0033623)2.62167605
168female mating behavior (GO:0060180)2.61509505
169photoreceptor cell maintenance (GO:0045494)2.61494294
170phagocytosis, engulfment (GO:0006911)2.60459013
171glutathione derivative biosynthetic process (GO:1901687)2.60287937
172glutathione derivative metabolic process (GO:1901685)2.60287937
173regulation of norepinephrine secretion (GO:0014061)2.60102253
174positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58574256
175cyclooxygenase pathway (GO:0019371)2.58482528
176relaxation of muscle (GO:0090075)2.58041521
177positive regulation of systemic arterial blood pressure (GO:0003084)2.57847277
178positive regulation of granulocyte differentiation (GO:0030854)2.57845445
179negative regulation of protein localization to cell surface (GO:2000009)2.57813740
180nucleoside diphosphate phosphorylation (GO:0006165)2.57451827
181granulocyte activation (GO:0036230)2.56306969
182purine-containing compound salvage (GO:0043101)2.55759848
183one-carbon compound transport (GO:0019755)2.54650257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.33712875
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.46150957
3E2F7_22180533_ChIP-Seq_HELA_Human4.32166546
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40094233
5SCL_19346495_ChIP-Seq_HPC-7_Human3.05721287
6SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94620049
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55503497
8GBX2_23144817_ChIP-Seq_PC3_Human2.53914911
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52531184
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50632006
11* RNF2_27304074_Chip-Seq_NSC_Mouse2.48415362
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.40447803
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31814365
14GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.26169715
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.23532738
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22421283
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.19515336
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.18781289
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17409885
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11795817
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00538485
22* GATA1_19941826_ChIP-Seq_K562_Human1.92057388
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.91445254
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90362306
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87979394
26TAF15_26573619_Chip-Seq_HEK293_Human1.85227396
27KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81006476
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80348123
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77544362
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73234552
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69717937
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69107548
33* GATA2_19941826_ChIP-Seq_K562_Human1.65828704
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.61347558
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60903156
36GATA1_22025678_ChIP-Seq_K562_Human1.59989823
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59386543
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57811454
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.57807944
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56867058
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.56690574
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55515040
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54981465
44SMAD4_21799915_ChIP-Seq_A2780_Human1.54515813
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53609563
46EZH2_22144423_ChIP-Seq_EOC_Human1.51324509
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48461003
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46251242
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.46032531
50RUNX1_26923725_Chip-Seq_HPCs_Mouse1.42900875
51STAT1_20625510_ChIP-Seq_HELA_Human1.41710246
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41119364
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39788712
54IGF1R_20145208_ChIP-Seq_DFB_Human1.38138036
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37903625
56RUNX_20019798_ChIP-Seq_JUKART_Human1.37560969
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37130859
58ER_23166858_ChIP-Seq_MCF-7_Human1.36696003
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35804204
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35739473
61P300_19829295_ChIP-Seq_ESCs_Human1.34964116
62SOX2_19829295_ChIP-Seq_ESCs_Human1.34901883
63NANOG_19829295_ChIP-Seq_ESCs_Human1.34901883
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34679156
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33994524
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33717505
67SMRT_27268052_Chip-Seq_Bcells_Human1.32563889
68* SPI1_23127762_ChIP-Seq_K562_Human1.32035949
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.31274272
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30939736
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.30736057
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29912281
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.28603635
74FUS_26573619_Chip-Seq_HEK293_Human1.27605559
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27339461
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27146881
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.26839407
78TCF4_23295773_ChIP-Seq_U87_Human1.26761377
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26313563
80VDR_22108803_ChIP-Seq_LS180_Human1.25589443
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24557169
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24557169
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24557169
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24551196
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24540568
86* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24477007
87BCAT_22108803_ChIP-Seq_LS180_Human1.24374946
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24205973
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23411369
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.23357466
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.23026894
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.22008886
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21459191
94AR_20517297_ChIP-Seq_VCAP_Human1.21312659
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.20911678
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20475730
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20475730
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20309001
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20194455
100HTT_18923047_ChIP-ChIP_STHdh_Human1.20130765
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.18873356
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18340179
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18255394
104STAT3_23295773_ChIP-Seq_U87_Human1.18165345
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17595204
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17353361
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.17237573
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17034895
109P300_18555785_Chip-Seq_ESCs_Mouse1.16483271
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16386570
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.16386570
112AR_25329375_ChIP-Seq_VCAP_Human1.16285026
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16081990
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15807812
115STAT3_18555785_ChIP-Seq_MESCs_Mouse1.15396129
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.14390822
117CEBPB_22108803_ChIP-Seq_LS180_Human1.14363292
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14181147
119ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13986489
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.13828612
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13590712
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13310572
123CDX2_22108803_ChIP-Seq_LS180_Human1.13210300
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.11947829
125* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11740225
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11085773
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11085773
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10845302
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10815356
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10196910
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.09984001
132PHF8_20622853_ChIP-Seq_HELA_Human1.09697705
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09245415
134GATA3_27048872_Chip-Seq_THYMUS_Human1.08912839
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08750780
136ETV1_20927104_ChIP-Seq_GIST48_Human1.08279152
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.08277908
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08170018
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07835597
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.07635140
141RBPJ_21746931_ChIP-Seq_IB4_Human1.07605814
142ERG_20517297_ChIP-Seq_VCAP_Human1.07386256
143ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07070619
144HNFA_21074721_ChIP-Seq_CACO-2_Human1.07026846
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06308977
146TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06209249
147NFYB_21822215_ChIP-Seq_K562_Human1.06034129
148GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.05179780
149NFYA_21822215_ChIP-Seq_K562_Human1.05020020
150KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04923686
151NMYC_18555785_Chip-Seq_ESCs_Mouse1.04142430
152SOX2_18555785_Chip-Seq_ESCs_Mouse1.04133838
153TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03880860
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03858854
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03146907
156NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02914608
157PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02640670
158TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02614550
159OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02467889
160GATA3_26560356_Chip-Seq_TH2_Human1.02045587
161GATA3_21867929_ChIP-Seq_TH1_Mouse1.01928803
162FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01719058
163CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01219784
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99639814
165JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99621393
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.99301348
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98956533
168P53_22387025_ChIP-Seq_ESCs_Mouse0.98703214
169EWS_26573619_Chip-Seq_HEK293_Human0.98012329
170SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97804180
171TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97385188
172ZFX_18555785_Chip-Seq_ESCs_Mouse0.96530614
173IRF1_19129219_ChIP-ChIP_H3396_Human0.95955168
174SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95952535
175* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95760689
176FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94383862
177SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94378549
178REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94158358
179NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93772734
180NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93414239
181SPI1_26923725_Chip-Seq_HPCs_Mouse0.93252196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.46839871
2MP0008877_abnormal_DNA_methylation6.35491672
3MP0005410_abnormal_fertilization5.74983775
4MP0002653_abnormal_ependyma_morphology4.39508914
5MP0008004_abnormal_stomach_pH4.35831402
6MP0008057_abnormal_DNA_replication4.06615677
7MP0001929_abnormal_gametogenesis3.87144666
8MP0003724_increased_susceptibility_to3.67174165
9MP0003698_abnormal_male_reproductive3.55279904
10MP0008058_abnormal_DNA_repair3.50472938
11MP0002210_abnormal_sex_determination3.37895428
12MP0002132_abnormal_respiratory_system3.37759250
13MP0010094_abnormal_chromosome_stability3.37747146
14MP0000465_gastrointestinal_hemorrhage3.04614231
15MP0008875_abnormal_xenobiotic_pharmacok2.89835907
16MP0001145_abnormal_male_reproductive2.84179461
17MP0000653_abnormal_sex_gland2.74953381
18MP0001984_abnormal_olfaction2.43299981
19MP0003890_abnormal_embryonic-extraembry2.40042012
20MP0003787_abnormal_imprinting2.27212503
21MP0004957_abnormal_blastocyst_morpholog2.24940450
22MP0002161_abnormal_fertility/fecundity2.22291761
23MP0000383_abnormal_hair_follicle2.20357004
24MP0003693_abnormal_embryo_hatching2.16393920
25MP0003123_paternal_imprinting2.15490664
26MP0003718_maternal_effect2.13545017
27MP0001835_abnormal_antigen_presentation2.01444721
28MP0005623_abnormal_meninges_morphology2.00290032
29MP0008872_abnormal_physiological_respon1.96942026
30MP0005397_hematopoietic_system_phenotyp1.94071946
31MP0001545_abnormal_hematopoietic_system1.94071946
32MP0003077_abnormal_cell_cycle1.89614090
33MP0002877_abnormal_melanocyte_morpholog1.89141271
34MP0000230_abnormal_systemic_arterial1.88847234
35MP0004084_abnormal_cardiac_muscle1.87151347
36MP0009780_abnormal_chondrocyte_physiolo1.87111145
37MP0003111_abnormal_nucleus_morphology1.85306654
38MP0003121_genomic_imprinting1.83404873
39MP0008775_abnormal_heart_ventricle1.76802560
40MP0003786_premature_aging1.75192718
41MP0002148_abnormal_hypersensitivity_rea1.71221114
42MP0006054_spinal_hemorrhage1.67919332
43MP0010155_abnormal_intestine_physiology1.66296721
44MP0009046_muscle_twitch1.63790719
45MP0005083_abnormal_biliary_tract1.60845288
46MP0008995_early_reproductive_senescence1.59496384
47MP0002736_abnormal_nociception_after1.57310639
48MP0006292_abnormal_olfactory_placode1.56945901
49MP0000343_altered_response_to1.54320560
50MP0003656_abnormal_erythrocyte_physiolo1.48473249
51MP0003828_pulmonary_edema1.48047302
52MP0001119_abnormal_female_reproductive1.46126845
53MP0009765_abnormal_xenobiotic_induced1.44104292
54MP0010307_abnormal_tumor_latency1.43882082
55MP0001968_abnormal_touch/_nociception1.43761797
56MP0001765_abnormal_ion_homeostasis1.42731204
57MP0008789_abnormal_olfactory_epithelium1.41300303
58MP0005646_abnormal_pituitary_gland1.40621550
59MP0005084_abnormal_gallbladder_morpholo1.39469789
60MP0001879_abnormal_lymphatic_vessel1.39405580
61MP0003699_abnormal_female_reproductive1.39180826
62MP0008932_abnormal_embryonic_tissue1.38838957
63MP0006072_abnormal_retinal_apoptosis1.38580302
64MP0003638_abnormal_response/metabolism_1.38467324
65MP0004215_abnormal_myocardial_fiber1.38052960
66MP0005167_abnormal_blood-brain_barrier1.31645989
67MP0004264_abnormal_extraembryonic_tissu1.31589064
68MP0003303_peritoneal_inflammation1.30692798
69MP0009763_increased_sensitivity_to1.30211734
70MP0000569_abnormal_digit_pigmentation1.29345325
71MP0002084_abnormal_developmental_patter1.29145547
72MP0001730_embryonic_growth_arrest1.27587454
73MP0002160_abnormal_reproductive_system1.24747349
74MP0004147_increased_porphyrin_level1.24240789
75MP0010678_abnormal_skin_adnexa1.24072233
76MP0005551_abnormal_eye_electrophysiolog1.16020506
77MP0002398_abnormal_bone_marrow1.15310707
78MP0005000_abnormal_immune_tolerance1.12772921
79MP0002085_abnormal_embryonic_tissue1.12571093
80MP0009764_decreased_sensitivity_to1.10280858
81MP0003646_muscle_fatigue1.09972855
82MP0008007_abnormal_cellular_replicative1.08380585
83MP0005389_reproductive_system_phenotype1.06992002
84MP0000350_abnormal_cell_proliferation1.06387182
85MP0005165_increased_susceptibility_to1.06357196
86MP0004043_abnormal_pH_regulation1.06075716
87MP0005394_taste/olfaction_phenotype1.05277135
88MP0005499_abnormal_olfactory_system1.05277135
89MP0001293_anophthalmia1.04076824
90MP0009278_abnormal_bone_marrow1.03395720
91MP0004133_heterotaxia1.02767210
92MP0001697_abnormal_embryo_size1.00421865
93MP0001851_eye_inflammation1.00058480
94MP0004036_abnormal_muscle_relaxation0.98236158
95MP0003183_abnormal_peptide_metabolism0.97548076
96MP0002723_abnormal_immune_serum0.97412902
97MP0001672_abnormal_embryogenesis/_devel0.95876891
98MP0005380_embryogenesis_phenotype0.95876891
99MP0005671_abnormal_response_to0.95660519
100MP0003119_abnormal_digestive_system0.95233364
101MP0002837_dystrophic_cardiac_calcinosis0.93984485
102MP0006035_abnormal_mitochondrial_morpho0.92668268
103MP0002452_abnormal_antigen_presenting0.91772544
104MP0000689_abnormal_spleen_morphology0.91077411
105MP0003136_yellow_coat_color0.90735440
106MP0002735_abnormal_chemical_nociception0.89718985
107MP0002733_abnormal_thermal_nociception0.89648315
108MP0010386_abnormal_urinary_bladder0.89580056
109MP0004484_altered_response_of0.88908569
110MP0001970_abnormal_pain_threshold0.88886280
111MP0000372_irregular_coat_pigmentation0.86997469
112MP0001800_abnormal_humoral_immune0.86591401
113MP0001664_abnormal_digestion0.85906345
114MP0000249_abnormal_blood_vessel0.85402907
115MP0000678_abnormal_parathyroid_gland0.81176120
116MP0001819_abnormal_immune_cell0.79586811
117MP0003937_abnormal_limbs/digits/tail_de0.79436307
118MP0005636_abnormal_mineral_homeostasis0.79269009
119MP0002420_abnormal_adaptive_immunity0.78795959
120MP0003879_abnormal_hair_cell0.78595572
121MP0004142_abnormal_muscle_tone0.78422688
122MP0000358_abnormal_cell_content/0.78192743
123MP0000313_abnormal_cell_death0.78084395
124MP0002722_abnormal_immune_system0.77811037
125MP0004233_abnormal_muscle_weight0.76651879
126MP0002572_abnormal_emotion/affect_behav0.76614598
127MP0002429_abnormal_blood_cell0.75519205
128MP0002405_respiratory_system_inflammati0.75419359
129MP0009642_abnormal_blood_homeostasis0.74939079
130MP0010368_abnormal_lymphatic_system0.74559729
131MP0003861_abnormal_nervous_system0.73148680
132MP0009333_abnormal_splenocyte_physiolog0.72740543
133MP0000858_altered_metastatic_potential0.72272217
134MP0002909_abnormal_adrenal_gland0.71941887
135MP0001663_abnormal_digestive_system0.71817498
136MP0003984_embryonic_growth_retardation0.70979549
137MP0005395_other_phenotype0.70515561
138MP0000631_abnormal_neuroendocrine_gland0.70466884
139MP0001485_abnormal_pinna_reflex0.70018833
140MP0009703_decreased_birth_body0.67883098
141MP0002088_abnormal_embryonic_growth/wei0.67681832
142MP0005025_abnormal_response_to0.67612152
143MP0008874_decreased_physiological_sensi0.67295912
144MP0001986_abnormal_taste_sensitivity0.66881858
145MP0002080_prenatal_lethality0.66703960
146MP0000716_abnormal_immune_system0.66673217
147MP0001845_abnormal_inflammatory_respons0.66451475
148MP0010329_abnormal_lipoprotein_level0.66241500
149MP0005266_abnormal_metabolism0.65246240
150MP0002086_abnormal_extraembryonic_tissu0.64561541
151MP0004270_analgesia0.63507544
152MP0001188_hyperpigmentation0.62595230
153MP0003880_abnormal_central_pattern0.62328686
154MP0000427_abnormal_hair_cycle0.61523089
155MP0005647_abnormal_sex_gland0.59436644
156MP0002928_abnormal_bile_duct0.58143890
157MP0002693_abnormal_pancreas_physiology0.56627253
158MP0005253_abnormal_eye_physiology0.55845001
159MP0004197_abnormal_fetal_growth/weight/0.54064762
160MP0002282_abnormal_trachea_morphology0.53326203
161MP0002102_abnormal_ear_morphology0.52212339
162MP0006276_abnormal_autonomic_nervous0.51137036
163MP0003943_abnormal_hepatobiliary_system0.50517094
164MP0006036_abnormal_mitochondrial_physio0.49775276
165MP0003122_maternal_imprinting0.49760718
166MP0000432_abnormal_head_morphology0.49256114
167MP0002152_abnormal_brain_morphology0.49157554
168MP0002184_abnormal_innervation0.48794311
169MP0000013_abnormal_adipose_tissue0.48155889
170MP0000462_abnormal_digestive_system0.48043388
171MP0002734_abnormal_mechanical_nocicepti0.47543174
172MP0003806_abnormal_nucleotide_metabolis0.47506043
173MP0005645_abnormal_hypothalamus_physiol0.47248559
174MP0009697_abnormal_copulation0.47245750
175MP0002751_abnormal_autonomic_nervous0.46783050
176MP0003635_abnormal_synaptic_transmissio0.46776248
177MP0002557_abnormal_social/conspecific_i0.45545238
178MP0004145_abnormal_muscle_electrophysio0.45368771
179MP0004811_abnormal_neuron_physiology0.44923195

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.22857394
2Abnormal ciliary motility (HP:0012262)6.42516938
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.09710089
4Absent/shortened dynein arms (HP:0200106)6.09710089
5Rhinitis (HP:0012384)6.05090342
6Chronic bronchitis (HP:0004469)5.97083241
7Prolonged bleeding time (HP:0003010)5.78098587
8Abnormal respiratory epithelium morphology (HP:0012253)5.30126034
9Abnormal respiratory motile cilium morphology (HP:0005938)5.30126034
10Male infertility (HP:0003251)5.05839264
11Petechiae (HP:0000967)4.64993921
12Menorrhagia (HP:0000132)4.48395426
13Increased mean platelet volume (HP:0011877)4.41169542
14Abnormal platelet volume (HP:0011876)4.15737857
15Infertility (HP:0000789)4.10416246
16Purpura (HP:0000979)4.06982188
17Abnormal spermatogenesis (HP:0008669)3.89765154
18Medial flaring of the eyebrow (HP:0010747)3.86394625
19Dyschromatopsia (HP:0007641)3.84983513
20Nasal polyposis (HP:0100582)3.75688457
21Bronchiectasis (HP:0002110)3.72493009
22Tongue fasciculations (HP:0001308)3.70449210
23Chronic otitis media (HP:0000389)3.60963951
24Epistaxis (HP:0000421)3.60615722
25Abnormality of the lower motor neuron (HP:0002366)3.56084903
26Chronic sinusitis (HP:0011109)3.55422816
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55397473
28Bronchitis (HP:0012387)3.51738566
29Chromsome breakage (HP:0040012)3.46393709
30Pancreatic fibrosis (HP:0100732)3.40278320
31Abnormality of the labia minora (HP:0012880)3.40054345
32Abnormality of midbrain morphology (HP:0002418)3.40040330
33Molar tooth sign on MRI (HP:0002419)3.40040330
34Supernumerary spleens (HP:0009799)3.36988478
35Congenital primary aphakia (HP:0007707)3.24217182
36Gait imbalance (HP:0002141)3.23233060
37Muscle fibrillation (HP:0010546)3.21419553
38Azoospermia (HP:0000027)3.09353684
39Decreased central vision (HP:0007663)3.07379351
40Nephronophthisis (HP:0000090)3.02690170
41Median cleft lip (HP:0000161)2.89148240
42Gingival bleeding (HP:0000225)2.86223899
43Papillary thyroid carcinoma (HP:0002895)2.84100875
44Abnormality of the nasal mucosa (HP:0000433)2.81575818
45Poor coordination (HP:0002370)2.80932432
46Nephrogenic diabetes insipidus (HP:0009806)2.79322896
47Spontaneous abortion (HP:0005268)2.70632399
48Impaired platelet aggregation (HP:0003540)2.66467301
49Abnormal platelet function (HP:0011869)2.66467301
50Facial cleft (HP:0002006)2.63469568
51Genital tract atresia (HP:0001827)2.61474213
52Intestinal atresia (HP:0011100)2.48785978
53Chronic hepatic failure (HP:0100626)2.43076149
54Vaginal atresia (HP:0000148)2.37011716
55Nephroblastoma (Wilms tumor) (HP:0002667)2.36067566
56Hyperlipoproteinemia (HP:0010980)2.34192747
57Postaxial foot polydactyly (HP:0001830)2.29071082
58Poikilocytosis (HP:0004447)2.27893469
59Stomatitis (HP:0010280)2.27846153
60Postaxial hand polydactyly (HP:0001162)2.21646280
61Acanthocytosis (HP:0001927)2.21429614
62Abnormality of the renal medulla (HP:0100957)2.18117672
63Abnormality of chromosome stability (HP:0003220)2.14536979
64Embryonal renal neoplasm (HP:0011794)2.12575542
65Central scotoma (HP:0000603)2.12367438
66Rhabdomyosarcoma (HP:0002859)2.09987044
67Pancreatic cysts (HP:0001737)2.09975936
68Cystic liver disease (HP:0006706)2.07860946
69Occipital encephalocele (HP:0002085)2.07319503
70Abnormality of lateral ventricle (HP:0030047)2.07243949
71Impulsivity (HP:0100710)2.05337648
72True hermaphroditism (HP:0010459)2.04714619
73Male pseudohermaphroditism (HP:0000037)2.04540240
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.00795011
75Spontaneous hematomas (HP:0007420)2.00404392
76Bifid tongue (HP:0010297)2.00024706
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4134541
78Facial hemangioma (HP:0000329)1.99636111
79Congenital hepatic fibrosis (HP:0002612)1.98213681
80Hyperactive renin-angiotensin system (HP:0000841)1.95261886
81Tubulointerstitial nephritis (HP:0001970)1.95037804
82Thyroid-stimulating hormone excess (HP:0002925)1.91582003
83Anencephaly (HP:0002323)1.89506260
84Abnormal pupillary function (HP:0007686)1.89401029
85Broad foot (HP:0001769)1.89132520
86Abnormality of the renal cortex (HP:0011035)1.88924086
87Abnormality of the heme biosynthetic pathway (HP:0010472)1.88922494
88Recurrent bronchitis (HP:0002837)1.88175450
89Oculomotor apraxia (HP:0000657)1.87268051
90Birth length less than 3rd percentile (HP:0003561)1.85916508
91Impaired smooth pursuit (HP:0007772)1.83238807
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83221638
93Amyotrophic lateral sclerosis (HP:0007354)1.83050358
94Medulloblastoma (HP:0002885)1.82480094
95Abnormality of the ileum (HP:0001549)1.81866923
96Abnormality of the preputium (HP:0100587)1.81711637
97Bile duct proliferation (HP:0001408)1.80990104
98Abnormal biliary tract physiology (HP:0012439)1.80990104
99Neoplasm of the oral cavity (HP:0100649)1.80504661
100Sloping forehead (HP:0000340)1.79416237
101Abolished electroretinogram (ERG) (HP:0000550)1.76880143
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.75667121
103Aganglionic megacolon (HP:0002251)1.75574236
104Gastrointestinal atresia (HP:0002589)1.75130148
105Shawl scrotum (HP:0000049)1.74626963
106Decreased testicular size (HP:0008734)1.74394417
107Meckel diverticulum (HP:0002245)1.73885004
108Abnormality of ocular smooth pursuit (HP:0000617)1.73699102
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72691381
110Recurrent otitis media (HP:0000403)1.72562231
111Decreased circulating renin level (HP:0003351)1.72557295
112Tubular atrophy (HP:0000092)1.72365016
113Aplasia/Hypoplasia of the lens (HP:0008063)1.71827483
114Conjunctival telangiectasia (HP:0000524)1.71507350
115Atelectasis (HP:0100750)1.71211904
116Specific learning disability (HP:0001328)1.69845339
117Sandal gap (HP:0001852)1.68600881
118Absent radius (HP:0003974)1.68493521
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.68116082
1203-Methylglutaconic aciduria (HP:0003535)1.68047892
121Asplenia (HP:0001746)1.67887098
122Short ribs (HP:0000773)1.67257245
123Optic nerve hypoplasia (HP:0000609)1.67020538
124Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63515619
125Abnormal drinking behavior (HP:0030082)1.63465832
126Polydipsia (HP:0001959)1.63465832
127Breast carcinoma (HP:0003002)1.62740224
128Ependymoma (HP:0002888)1.61901817
129Thyroid carcinoma (HP:0002890)1.61805921
130Recurrent sinusitis (HP:0011108)1.61402259
131Absent forearm bone (HP:0003953)1.61369299
132Aplasia involving forearm bones (HP:0009822)1.61369299
133Neoplasm of striated muscle (HP:0009728)1.60458780
13411 pairs of ribs (HP:0000878)1.59675289
135Hypochromic microcytic anemia (HP:0004840)1.58053342
136Bony spicule pigmentary retinopathy (HP:0007737)1.57106000
137Cystic hygroma (HP:0000476)1.57000964
138Abnormal biliary tract morphology (HP:0012440)1.56603547
139Nephropathy (HP:0000112)1.56248452
140Patellar aplasia (HP:0006443)1.56159073
141Sclerocornea (HP:0000647)1.54695014
142Bruising susceptibility (HP:0000978)1.51213621
143Abnormality of the vasculature of the conjunctiva (HP:0008054)1.51184729
144Abnormality of transition element cation homeostasis (HP:0011030)1.50442767
145Abnormality of iron homeostasis (HP:0011031)1.49780482
146Furrowed tongue (HP:0000221)1.49378866
147Portal hypertension (HP:0001409)1.46215778
148Cone-rod dystrophy (HP:0000548)1.44979752
149Hypokalemic alkalosis (HP:0001949)1.43820508
150Abnormality of macular pigmentation (HP:0008002)1.40936441
151Renal cortical cysts (HP:0000803)1.34115994
152Episodic fever (HP:0001954)1.32722028
153Paralysis (HP:0003470)1.32147320
154Abnormal rod and cone electroretinograms (HP:0008323)1.31998630
155Elevated erythrocyte sedimentation rate (HP:0003565)1.31139816
156Abnormality of the hepatic vasculature (HP:0006707)1.29376158
157Tubulointerstitial abnormality (HP:0001969)1.29291306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.46611456
2PDK33.80860687
3PDK43.80860687
4CDC73.59009175
5RIPK43.51331379
6PDK22.85646724
7TTK2.82186409
8TEC2.81382054
9AKT32.80731245
10MAP3K62.75361418
11MAP2K72.53440599
12CDK122.50272799
13ADRBK22.43574064
14ACVR1B2.40733142
15STK38L2.33980179
16MYLK2.27199748
17MAP3K42.25901277
18BTK2.23927908
19BRAF2.22164318
20NUAK12.16212035
21MAPK152.16184930
22WEE12.13352658
23NEK11.98794718
24PINK11.96959727
25CSF1R1.89433840
26PRKD31.89197211
27BMX1.88429251
28ICK1.84453575
29BRSK21.82941500
30IRAK11.79950159
31CHEK21.75092129
32PLK11.70124109
33MAP3K91.69370859
34ARAF1.61028712
35TNIK1.58719606
36PNCK1.54994464
37SYK1.42865118
38MAPKAPK31.42754663
39STK31.42719841
40PLK41.42486934
41PTK2B1.40647988
42STK241.40317461
43BMPR1B1.37137502
44GRK61.37100845
45MUSK1.34840726
46TSSK61.34543964
47MAP4K21.32643490
48EIF2AK11.32160913
49PIK3CG1.30048481
50STK381.23374267
51BMPR21.21784606
52TXK1.19685507
53ERBB41.19050738
54CHEK11.16507587
55ADRBK11.12362952
56WNK41.11680042
57ITK1.08682365
58BCKDK1.07664600
59PASK1.07125689
60AURKA1.06503039
61ZAP701.04342509
62ATR1.04027001
63LATS21.01166350
64TYRO31.00233439
65CASK1.00199707
66ILK0.98436063
67LATS10.96786166
68NEK20.95628444
69ATM0.95492891
70CDK70.94968979
71PLK30.94024091
72FES0.93637219
73NTRK30.92737920
74BRSK10.90911014
75DAPK10.87517092
76HCK0.87156894
77MAP2K40.83943321
78EEF2K0.83610963
79IKBKB0.83397831
80TLK10.82951405
81WNK30.82203306
82PRKCI0.81410877
83MOS0.79887115
84INSRR0.79887108
85CCNB10.78410078
86EPHA30.77916879
87GRK10.77093336
88LYN0.76832382
89CDC42BPA0.76279628
90PRKCQ0.76142259
91FLT30.73271411
92TNK20.72948620
93MAP3K120.72820894
94TAOK30.72486133
95MAPK130.70158710
96KIT0.69816692
97CSK0.69466672
98STK40.68470741
99FER0.66747059
100ERBB20.65855116
101SRPK10.65150745
102PAK10.65114404
103CDK20.64709712
104CDK80.63026752
105LRRK20.62622125
106TRIM280.59767524
107ZAK0.59185913
108CDK10.57275374
109RPS6KB20.55945257
110PLK20.55891471
111KSR20.55590816
112AURKB0.54463976
113EPHA20.53422042
114MELK0.53066727
115CDK90.50934693
116MAP2K10.50596224
117MAPKAPK50.49462631
118OXSR10.48700756
119STK160.48335807
120NLK0.47752989
121PRKG10.46600383
122BUB10.46523756
123DYRK30.45680483
124RAF10.45655283
125CDK30.44270275
126GRK50.43160099
127MAP3K50.41928752
128CSNK1E0.41902110
129PRKAA10.41314450
130MAP3K20.41114637
131STK100.40964979
132STK390.40705374
133TRPM70.40194636
134TBK10.40019363
135MATK0.39177932
136MAP2K20.38382908
137PRKD10.38041877
138PRKCD0.37311398
139DAPK20.37227740
140PRPF4B0.36765271
141BLK0.36383764
142ABL10.36378240
143CSNK1G20.36339831
144GSK3B0.35665807
145CSNK2A20.35550618
146PRKCG0.35287200
147DYRK1A0.35089441
148FGR0.34968338
149MARK30.34853942
150PRKDC0.34293040
151PRKACG0.34248192
152MAPK100.34235907
153PRKCA0.34105763
154MAPK140.33922268
155ERBB30.32694737
156MAP3K30.31950679
157RPS6KB10.31920670
158LCK0.31492437
159PIM20.30871277
160PRKCE0.30491596
161PDK10.29214523
162IGF1R0.29105418
163PRKACA0.28994474
164FRK0.26811722
165KSR10.25107550
166BCR0.25043861
167MINK10.24782761
168VRK10.24425849
169NEK60.23678501
170CAMK2A0.23258524
171CSNK2A10.22686558

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.20246363
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15644183
3Platelet activation_Homo sapiens_hsa046114.11458461
4Fanconi anemia pathway_Homo sapiens_hsa034603.33184748
5Nitrogen metabolism_Homo sapiens_hsa009103.13131871
6Mismatch repair_Homo sapiens_hsa034303.09091307
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.07879469
8Homologous recombination_Homo sapiens_hsa034402.82914357
9RNA transport_Homo sapiens_hsa030132.80479628
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.77409092
11Cell cycle_Homo sapiens_hsa041102.74385894
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.70239734
13Chemical carcinogenesis_Homo sapiens_hsa052042.68399440
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.66202901
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.49898736
16Oocyte meiosis_Homo sapiens_hsa041142.44019932
17Base excision repair_Homo sapiens_hsa034102.42625634
18RNA degradation_Homo sapiens_hsa030182.37958456
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37112840
20Vitamin B6 metabolism_Homo sapiens_hsa007502.33719900
21mRNA surveillance pathway_Homo sapiens_hsa030152.31731539
22DNA replication_Homo sapiens_hsa030302.29067209
23Olfactory transduction_Homo sapiens_hsa047402.23273784
24Hematopoietic cell lineage_Homo sapiens_hsa046402.09143998
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.02727643
26Nucleotide excision repair_Homo sapiens_hsa034201.91919000
27Glutathione metabolism_Homo sapiens_hsa004801.91917413
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.81142746
29Non-homologous end-joining_Homo sapiens_hsa034501.70308983
30beta-Alanine metabolism_Homo sapiens_hsa004101.63958095
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63171804
32Phototransduction_Homo sapiens_hsa047441.57336419
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57107292
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54089247
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.51493354
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49673739
37Spliceosome_Homo sapiens_hsa030401.49133495
38Taste transduction_Homo sapiens_hsa047421.46756180
39Linoleic acid metabolism_Homo sapiens_hsa005911.45836248
40Purine metabolism_Homo sapiens_hsa002301.40455197
41RNA polymerase_Homo sapiens_hsa030201.38898068
42Systemic lupus erythematosus_Homo sapiens_hsa053221.37792259
43Fatty acid elongation_Homo sapiens_hsa000621.37449680
44Tyrosine metabolism_Homo sapiens_hsa003501.37136954
45Ovarian steroidogenesis_Homo sapiens_hsa049131.31927940
46Insulin secretion_Homo sapiens_hsa049111.31526246
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.30890907
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26448877
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24799367
50Glucagon signaling pathway_Homo sapiens_hsa049221.23287327
51Retinol metabolism_Homo sapiens_hsa008301.23122033
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22103213
53Pentose phosphate pathway_Homo sapiens_hsa000301.20809172
54Allograft rejection_Homo sapiens_hsa053301.19819513
55Amphetamine addiction_Homo sapiens_hsa050311.16722419
56Asthma_Homo sapiens_hsa053101.16068009
57Gap junction_Homo sapiens_hsa045401.15999948
58Pancreatic secretion_Homo sapiens_hsa049721.15706256
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.14304509
60Dorso-ventral axis formation_Homo sapiens_hsa043201.10753478
61Histidine metabolism_Homo sapiens_hsa003401.07890665
62Huntingtons disease_Homo sapiens_hsa050161.07109095
63Synaptic vesicle cycle_Homo sapiens_hsa047211.05300244
64Salivary secretion_Homo sapiens_hsa049701.04177512
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03987168
66Glycerolipid metabolism_Homo sapiens_hsa005611.03570717
67Protein export_Homo sapiens_hsa030601.01416481
68Pyrimidine metabolism_Homo sapiens_hsa002401.01141726
69p53 signaling pathway_Homo sapiens_hsa041151.00790246
70Caffeine metabolism_Homo sapiens_hsa002321.00514102
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00425949
72Peroxisome_Homo sapiens_hsa041460.99857656
73Pyruvate metabolism_Homo sapiens_hsa006200.99414981
74ECM-receptor interaction_Homo sapiens_hsa045120.99396935
75ABC transporters_Homo sapiens_hsa020100.96999717
76Renin-angiotensin system_Homo sapiens_hsa046140.96677278
77Sphingolipid metabolism_Homo sapiens_hsa006000.95914939
78Chemokine signaling pathway_Homo sapiens_hsa040620.94617708
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90413583
80Sulfur metabolism_Homo sapiens_hsa009200.86704969
81Selenocompound metabolism_Homo sapiens_hsa004500.86204792
82Lysine degradation_Homo sapiens_hsa003100.85286716
83Long-term potentiation_Homo sapiens_hsa047200.84085676
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83998982
85Starch and sucrose metabolism_Homo sapiens_hsa005000.83589815
86Graft-versus-host disease_Homo sapiens_hsa053320.81935726
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81002840
88Autoimmune thyroid disease_Homo sapiens_hsa053200.79889314
89Collecting duct acid secretion_Homo sapiens_hsa049660.79112185
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76522972
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76249590
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74806912
93Phenylalanine metabolism_Homo sapiens_hsa003600.73470568
94Biosynthesis of amino acids_Homo sapiens_hsa012300.70461653
95Vibrio cholerae infection_Homo sapiens_hsa051100.69718720
96Type I diabetes mellitus_Homo sapiens_hsa049400.68314830
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67708914
98Renin secretion_Homo sapiens_hsa049240.66953251
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.64942699
100Ether lipid metabolism_Homo sapiens_hsa005650.64731239
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63792716
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63267957
103Dopaminergic synapse_Homo sapiens_hsa047280.62988444
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61855095
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.59612408
106Primary immunodeficiency_Homo sapiens_hsa053400.59180749
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58888117
108mTOR signaling pathway_Homo sapiens_hsa041500.57224138
109Circadian rhythm_Homo sapiens_hsa047100.57154102
110Staphylococcus aureus infection_Homo sapiens_hsa051500.55733926
111Estrogen signaling pathway_Homo sapiens_hsa049150.55288420
112Fatty acid biosynthesis_Homo sapiens_hsa000610.55218859
113Fructose and mannose metabolism_Homo sapiens_hsa000510.54883867
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.54519635
115Thyroid cancer_Homo sapiens_hsa052160.53064568
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52141379
117Butanoate metabolism_Homo sapiens_hsa006500.51936184
118Nicotine addiction_Homo sapiens_hsa050330.51731773
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51023089
120Fatty acid degradation_Homo sapiens_hsa000710.50444911
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50295199
122Viral carcinogenesis_Homo sapiens_hsa052030.49415737
123Hippo signaling pathway_Homo sapiens_hsa043900.49283856
124Leishmaniasis_Homo sapiens_hsa051400.49236371
125Legionellosis_Homo sapiens_hsa051340.46938731
126Choline metabolism in cancer_Homo sapiens_hsa052310.46103350
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.45788328
128cAMP signaling pathway_Homo sapiens_hsa040240.44305543
129Malaria_Homo sapiens_hsa051440.44108789
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44000905
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43989913
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43787517
133Arachidonic acid metabolism_Homo sapiens_hsa005900.43017206
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.42750547
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42048393
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41938659
137Cocaine addiction_Homo sapiens_hsa050300.41905136
138Propanoate metabolism_Homo sapiens_hsa006400.41432795
139Endocytosis_Homo sapiens_hsa041440.41425155
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40214383
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40175135
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39417496
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39273397
144Long-term depression_Homo sapiens_hsa047300.39170031
145Serotonergic synapse_Homo sapiens_hsa047260.38195100
146GABAergic synapse_Homo sapiens_hsa047270.37426155
147Regulation of autophagy_Homo sapiens_hsa041400.37143620
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36626148
149Epstein-Barr virus infection_Homo sapiens_hsa051690.36593967
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.36570171
151Rheumatoid arthritis_Homo sapiens_hsa053230.36453013
152Alcoholism_Homo sapiens_hsa050340.35539432
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35366855
154Circadian entrainment_Homo sapiens_hsa047130.34420011
155Hedgehog signaling pathway_Homo sapiens_hsa043400.32968872
156Calcium signaling pathway_Homo sapiens_hsa040200.32882129
157Glutamatergic synapse_Homo sapiens_hsa047240.32363675
158Phagosome_Homo sapiens_hsa041450.32153893
159Wnt signaling pathway_Homo sapiens_hsa043100.31083462
160One carbon pool by folate_Homo sapiens_hsa006700.30156515
161HTLV-I infection_Homo sapiens_hsa051660.29938402
162Inositol phosphate metabolism_Homo sapiens_hsa005620.28512366
163TGF-beta signaling pathway_Homo sapiens_hsa043500.28225193
164Morphine addiction_Homo sapiens_hsa050320.27953983
165Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25448038
166Thyroid hormone synthesis_Homo sapiens_hsa049180.25336749
167Type II diabetes mellitus_Homo sapiens_hsa049300.24603631
168Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24294866
169Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23588870
170Proteasome_Homo sapiens_hsa030500.23558758
171Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23151703
172Tight junction_Homo sapiens_hsa045300.22632801
173GnRH signaling pathway_Homo sapiens_hsa049120.22272609

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