EFL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)4.38397500
2nucleobase biosynthetic process (GO:0046112)4.22688677
3mitotic chromosome condensation (GO:0007076)4.21339537
4purine nucleobase biosynthetic process (GO:0009113)4.16649771
5folic acid-containing compound biosynthetic process (GO:0009396)4.09682239
6regulation of centriole replication (GO:0046599)3.89617556
7IMP metabolic process (GO:0046040)3.80932769
8ribosomal small subunit assembly (GO:0000028)3.78106443
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76994845
10non-recombinational repair (GO:0000726)3.73670553
11double-strand break repair via nonhomologous end joining (GO:0006303)3.73670553
12mitotic metaphase plate congression (GO:0007080)3.65804106
13sister chromatid segregation (GO:0000819)3.64948510
14nuclear pore organization (GO:0006999)3.63302479
15protein localization to kinetochore (GO:0034501)3.61711702
16ribosome assembly (GO:0042255)3.60621543
17pre-miRNA processing (GO:0031054)3.53440992
18nuclear pore complex assembly (GO:0051292)3.49334944
19formation of translation preinitiation complex (GO:0001731)3.44872106
20maturation of SSU-rRNA (GO:0030490)3.44866933
21mitotic nuclear envelope disassembly (GO:0007077)3.44565731
22mitotic spindle checkpoint (GO:0071174)3.44393198
23spindle checkpoint (GO:0031577)3.42009158
24regulation of chromosome segregation (GO:0051983)3.39588347
25DNA deamination (GO:0045006)3.39361154
26negative regulation of chromosome segregation (GO:0051985)3.36670411
27negative regulation of mitotic sister chromatid separation (GO:2000816)3.36198278
28negative regulation of sister chromatid segregation (GO:0033046)3.36198278
29negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36198278
30negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36198278
31negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36198278
32DNA strand elongation involved in DNA replication (GO:0006271)3.35398708
33DNA replication initiation (GO:0006270)3.29294769
34maturation of 5.8S rRNA (GO:0000460)3.28927025
35paraxial mesoderm development (GO:0048339)3.28060863
36metaphase plate congression (GO:0051310)3.27018715
37regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26701796
38regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26701796
39DNA strand elongation (GO:0022616)3.26495121
40mitotic spindle assembly checkpoint (GO:0007094)3.25514641
41chromatin remodeling at centromere (GO:0031055)3.24256801
42ribosome biogenesis (GO:0042254)3.20122089
43DNA replication-dependent nucleosome assembly (GO:0006335)3.19786897
44DNA replication-dependent nucleosome organization (GO:0034723)3.19786897
45spindle assembly checkpoint (GO:0071173)3.18905317
46telomere maintenance via semi-conservative replication (GO:0032201)3.17916308
47daunorubicin metabolic process (GO:0044597)3.16956882
48polyketide metabolic process (GO:0030638)3.16956882
49doxorubicin metabolic process (GO:0044598)3.16956882
50chromosome condensation (GO:0030261)3.15299455
51CENP-A containing nucleosome assembly (GO:0034080)3.14967279
52regulation of sister chromatid segregation (GO:0033045)3.14829670
53regulation of mitotic sister chromatid separation (GO:0010965)3.14829670
54regulation of mitotic sister chromatid segregation (GO:0033047)3.14829670
55ribosomal large subunit biogenesis (GO:0042273)3.13435456
56membrane disassembly (GO:0030397)3.09204612
57nuclear envelope disassembly (GO:0051081)3.09204612
58DNA ligation (GO:0006266)3.03596914
59establishment of viral latency (GO:0019043)3.02723358
60regulation of sister chromatid cohesion (GO:0007063)3.02633199
61protein localization to chromosome, centromeric region (GO:0071459)3.02530226
62DNA unwinding involved in DNA replication (GO:0006268)3.01486952
63regulation of spindle organization (GO:0090224)3.01419438
64protein complex localization (GO:0031503)3.00417702
65establishment of chromosome localization (GO:0051303)3.00267792
66telomere maintenance via recombination (GO:0000722)2.98920100
67response to X-ray (GO:0010165)2.97886671
68cellular protein complex localization (GO:0034629)2.97308449
69negative regulation of DNA repair (GO:0045738)2.95957749
70DNA conformation change (GO:0071103)2.95396045
71mitotic recombination (GO:0006312)2.94614533
72sister chromatid cohesion (GO:0007062)2.93339708
73DNA replication checkpoint (GO:0000076)2.91815038
74ribonucleoprotein complex biogenesis (GO:0022613)2.90778744
75DNA synthesis involved in DNA repair (GO:0000731)2.90229594
76positive regulation of chromosome segregation (GO:0051984)2.89624200
77DNA topological change (GO:0006265)2.89614081
78DNA packaging (GO:0006323)2.89264359
79ATP-dependent chromatin remodeling (GO:0043044)2.89159993
80histone mRNA catabolic process (GO:0071044)2.89150380
81replication fork processing (GO:0031297)2.89047130
82rRNA processing (GO:0006364)2.88823486
83RNA-dependent DNA replication (GO:0006278)2.88008331
84mitotic G2/M transition checkpoint (GO:0044818)2.85313420
85regulation of centrosome cycle (GO:0046605)2.85280668
86tetrahydrofolate metabolic process (GO:0046653)2.85133176
87rRNA metabolic process (GO:0016072)2.84845049
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84766841
89mitochondrial DNA replication (GO:0006264)2.82984296
90telomere maintenance via telomere lengthening (GO:0010833)2.82576721
91regulation of translational fidelity (GO:0006450)2.82307682
92DNA duplex unwinding (GO:0032508)2.81667105
93heterochromatin organization (GO:0070828)2.81107547
94histone mRNA metabolic process (GO:0008334)2.80729532
95DNA geometric change (GO:0032392)2.80512897
96telomere maintenance via telomerase (GO:0007004)2.79686828
97regulation of helicase activity (GO:0051095)2.79293113
98regulation of centrosome duplication (GO:0010824)2.79277626
99mitotic sister chromatid cohesion (GO:0007064)2.79050545
100tRNA aminoacylation for protein translation (GO:0006418)2.78965690
101viral transcription (GO:0019083)2.77281664
102base-excision repair, AP site formation (GO:0006285)2.77245771
103translational termination (GO:0006415)2.76440062
104DNA replication-independent nucleosome organization (GO:0034724)2.75337064
105DNA replication-independent nucleosome assembly (GO:0006336)2.75337064
106attachment of spindle microtubules to kinetochore (GO:0008608)2.74004210
107pseudouridine synthesis (GO:0001522)2.72727510
108mitochondrial DNA metabolic process (GO:0032042)2.71039332
109mismatch repair (GO:0006298)2.69855621
110telomere maintenance (GO:0000723)2.69395980
111amino acid activation (GO:0043038)2.68538765
112tRNA aminoacylation (GO:0043039)2.68538765
113telomere organization (GO:0032200)2.67928462
114chromosome segregation (GO:0007059)2.67615202
115Golgi transport vesicle coating (GO:0048200)2.67252441
116COPI coating of Golgi vesicle (GO:0048205)2.67252441
117regulation of DNA endoreduplication (GO:0032875)2.66622804
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.65943173
119pteridine-containing compound biosynthetic process (GO:0042559)2.65336559
120regulation of RNA export from nucleus (GO:0046831)2.64357770
121energy homeostasis (GO:0097009)2.63264655
122chromatin assembly or disassembly (GO:0006333)2.61339742
123somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61216815
124isotype switching (GO:0045190)2.61216815
125somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61216815
126snRNA processing (GO:0016180)2.60504044
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60402919
128DNA strand renaturation (GO:0000733)2.58426185
129translational elongation (GO:0006414)2.58145539
130SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57459323
131pore complex assembly (GO:0046931)2.57197770
132deoxyribonucleotide catabolic process (GO:0009264)2.57071554
133translational initiation (GO:0006413)2.57047800
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55911432
135histone exchange (GO:0043486)2.53675473
136kinetochore organization (GO:0051383)2.53406871
137regulation of histone H3-K9 methylation (GO:0051570)2.52611535
138purine deoxyribonucleotide catabolic process (GO:0009155)2.51485493
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50175858
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.50175858
141base-excision repair (GO:0006284)2.49266963
142meiotic chromosome segregation (GO:0045132)2.48553432
143spliceosomal snRNP assembly (GO:0000387)2.48357734
144transcription-coupled nucleotide-excision repair (GO:0006283)2.48275407
145histone-serine phosphorylation (GO:0035404)2.48051203
146cotranslational protein targeting to membrane (GO:0006613)2.47977970
147protein targeting to ER (GO:0045047)2.47215931
148ncRNA catabolic process (GO:0034661)2.46655427
149regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46508866
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.46322725
151antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46322725
152viral mRNA export from host cell nucleus (GO:0046784)2.45949302
153rRNA transcription (GO:0009303)2.45366242
154spliceosomal complex assembly (GO:0000245)2.45287727
155establishment of integrated proviral latency (GO:0075713)2.43174110
156folic acid-containing compound metabolic process (GO:0006760)2.41948873
157mitotic sister chromatid segregation (GO:0000070)2.41896881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.87182208
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22216347
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35709825
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22702348
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09499560
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.87981264
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81597515
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81346572
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.78794798
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.64922727
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59884099
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59017995
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50739688
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46504123
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44943938
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32707323
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.29514508
18VDR_23849224_ChIP-Seq_CD4+_Human2.25109249
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18694673
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11499520
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07524786
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07011184
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04085571
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.03416502
25ELK1_19687146_ChIP-ChIP_HELA_Human2.00059908
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96953955
27FOXP3_21729870_ChIP-Seq_TREG_Human1.95591016
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90707029
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90248640
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90024617
31XRN2_22483619_ChIP-Seq_HELA_Human1.89033937
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85001160
33DCP1A_22483619_ChIP-Seq_HELA_Human1.78586858
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75404730
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73731380
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72474128
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.70518767
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68534278
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67802938
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66330316
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63855509
42TTF2_22483619_ChIP-Seq_HELA_Human1.61796886
43AR_21909140_ChIP-Seq_LNCAP_Human1.61761609
44MYC_22102868_ChIP-Seq_BL_Human1.58996949
45GABP_19822575_ChIP-Seq_HepG2_Human1.58020810
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57953657
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.55519926
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53219017
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53215400
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52858183
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51500443
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50615405
53KDM5A_27292631_Chip-Seq_BREAST_Human1.49703954
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.49692202
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48502991
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47331220
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43522701
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42794288
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42724853
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39033440
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.34410526
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34134434
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32709246
64SPI1_23547873_ChIP-Seq_NB4_Human1.31658606
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.31146926
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28224306
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.28138676
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25358128
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24482637
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.22858590
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.22431168
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22023290
73CIITA_25753668_ChIP-Seq_RAJI_Human1.20526602
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19583402
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.19553127
76CHD1_26751641_Chip-Seq_LNCaP_Human1.16742561
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15943782
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15165894
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13708348
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13706754
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11557623
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11538194
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09124532
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08600997
85CLOCK_20551151_ChIP-Seq_293T_Human1.06182622
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05443012
87BRD4_25478319_ChIP-Seq_HGPS_Human1.05178652
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03162574
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03030766
90MYC_18940864_ChIP-ChIP_HL60_Human1.02587953
91MYB_26560356_Chip-Seq_TH2_Human1.01966082
92TFEB_21752829_ChIP-Seq_HELA_Human1.00733053
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99471798
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98492806
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97555097
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96485601
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95880022
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95855876
99MYB_26560356_Chip-Seq_TH1_Human0.94709747
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94624959
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.94186503
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93472497
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93472497
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92753413
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90892328
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89753354
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89591676
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89314691
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88523476
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88244191
111ELK1_22589737_ChIP-Seq_MCF10A_Human0.88243274
112GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88156161
113FUS_26573619_Chip-Seq_HEK293_Human0.85462698
114EWS_26573619_Chip-Seq_HEK293_Human0.85306055
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84397033
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83622215
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.83516269
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81410370
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81343835
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80994929
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80388147
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80263238
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.80007075
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79635926
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79471318
126TP63_17297297_ChIP-ChIP_HaCaT_Human0.78363747
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76975248
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76824851
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76722139
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74893945
131IRF1_19129219_ChIP-ChIP_H3396_Human0.74663357
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74547100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.88340740
2MP0010094_abnormal_chromosome_stability3.71203616
3MP0003111_abnormal_nucleus_morphology3.44408947
4MP0003941_abnormal_skin_development3.43625686
5MP0004957_abnormal_blastocyst_morpholog3.26749180
6MP0003077_abnormal_cell_cycle3.17261967
7MP0008058_abnormal_DNA_repair3.00747696
8MP0002396_abnormal_hematopoietic_system2.61863593
9MP0008007_abnormal_cellular_replicative2.61571947
10MP0003890_abnormal_embryonic-extraembry2.38488403
11MP0008057_abnormal_DNA_replication2.14448294
12MP0002877_abnormal_melanocyte_morpholog1.98349063
13MP0003705_abnormal_hypodermis_morpholog1.95619197
14MP0000350_abnormal_cell_proliferation1.92350889
15MP0004272_abnormal_basement_membrane1.89672763
16MP0001730_embryonic_growth_arrest1.82316739
17MP0008932_abnormal_embryonic_tissue1.74781501
18MP0003806_abnormal_nucleotide_metabolis1.73116224
19MP0010352_gastrointestinal_tract_polyps1.71864273
20MP0004233_abnormal_muscle_weight1.63487075
21MP0003763_abnormal_thymus_physiology1.61213404
22MP0000490_abnormal_crypts_of1.61053931
23MP0003950_abnormal_plasma_membrane1.58547930
24MP0009333_abnormal_splenocyte_physiolog1.55258381
25MP0004808_abnormal_hematopoietic_stem1.52490194
26MP0006054_spinal_hemorrhage1.50510504
27MP0003186_abnormal_redox_activity1.50121380
28MP0001835_abnormal_antigen_presentation1.48607802
29MP0002398_abnormal_bone_marrow1.45208822
30MP0000313_abnormal_cell_death1.44841448
31MP0004264_abnormal_extraembryonic_tissu1.43660273
32MP0002796_impaired_skin_barrier1.43125173
33MP0003786_premature_aging1.42326047
34MP0001672_abnormal_embryogenesis/_devel1.41088981
35MP0005380_embryogenesis_phenotype1.41088981
36MP0002019_abnormal_tumor_incidence1.39058108
37MP0000579_abnormal_nail_morphology1.38756154
38MP0010678_abnormal_skin_adnexa1.34846060
39MP0000689_abnormal_spleen_morphology1.34734788
40MP0000537_abnormal_urethra_morphology1.34479039
41MP0001800_abnormal_humoral_immune1.33880402
42MP0003937_abnormal_limbs/digits/tail_de1.33625309
43MP0010307_abnormal_tumor_latency1.33243329
44MP0005023_abnormal_wound_healing1.30541140
45MP0001849_ear_inflammation1.30352266
46MP0001293_anophthalmia1.27918695
47MP0002722_abnormal_immune_system1.27256421
48MP0002088_abnormal_embryonic_growth/wei1.26885935
49MP0003984_embryonic_growth_retardation1.25851430
50MP0008877_abnormal_DNA_methylation1.24796308
51MP0005671_abnormal_response_to1.24484713
52MP0009672_abnormal_birth_weight1.23905406
53MP0002086_abnormal_extraembryonic_tissu1.23836491
54MP0002452_abnormal_antigen_presenting1.22611792
55MP0001545_abnormal_hematopoietic_system1.22603097
56MP0005397_hematopoietic_system_phenotyp1.22603097
57MP0003566_abnormal_cell_adhesion1.22158793
58MP0000703_abnormal_thymus_morphology1.21595100
59MP0002080_prenatal_lethality1.20649307
60MP0005076_abnormal_cell_differentiation1.19449568
61MP0002420_abnormal_adaptive_immunity1.18520151
62MP0003183_abnormal_peptide_metabolism1.17538276
63MP0001819_abnormal_immune_cell1.16466110
64MP0010234_abnormal_vibrissa_follicle1.15524466
65MP0003123_paternal_imprinting1.15214161
66MP0000685_abnormal_immune_system1.14821558
67MP0003718_maternal_effect1.14513525
68MP0001661_extended_life_span1.13437977
69MP0003436_decreased_susceptibility_to1.13184788
70MP0001915_intracranial_hemorrhage1.12902943
71MP0002429_abnormal_blood_cell1.12778185
72MP0002723_abnormal_immune_serum1.12244894
73MP0000716_abnormal_immune_system1.12177171
74MP0010030_abnormal_orbit_morphology1.10335864
75MP0002697_abnormal_eye_size1.09500254
76MP0001697_abnormal_embryo_size1.09486002
77MP0005075_abnormal_melanosome_morpholog1.09059827
78MP0002132_abnormal_respiratory_system1.07863711
79MP0008438_abnormal_cutaneous_collagen1.06483087
80MP0005257_abnormal_intraocular_pressure1.04511418
81MP0001853_heart_inflammation1.02700822
82MP0000762_abnormal_tongue_morphology1.02256308
83MP0003221_abnormal_cardiomyocyte_apopto1.00905758
84MP0002085_abnormal_embryonic_tissue1.00180536
85MP0004133_heterotaxia0.99441504
86MP0002084_abnormal_developmental_patter0.99301629
87MP0001790_abnormal_immune_system0.98029640
88MP0005387_immune_system_phenotype0.98029640
89MP0000858_altered_metastatic_potential0.97603049
90MP0003866_abnormal_defecation0.97250552
91MP0005623_abnormal_meninges_morphology0.95661390
92MP0002933_joint_inflammation0.95372899
93MP0002233_abnormal_nose_morphology0.94143027
94MP0003453_abnormal_keratinocyte_physiol0.91540430
95MP0000377_abnormal_hair_follicle0.91230168
96MP0001216_abnormal_epidermal_layer0.90771568
97MP0008004_abnormal_stomach_pH0.89456469
98MP0010155_abnormal_intestine_physiology0.88852992
99MP0005000_abnormal_immune_tolerance0.88720769
100MP0000428_abnormal_craniofacial_morphol0.88571663
101MP0009703_decreased_birth_body0.88091931
102MP0002148_abnormal_hypersensitivity_rea0.86811145
103MP0002092_abnormal_eye_morphology0.86699758
104MP0003121_genomic_imprinting0.85462660
105MP0005451_abnormal_body_composition0.84452251
106MP0001243_abnormal_dermal_layer0.84428716
107MP0002254_reproductive_system_inflammat0.83848212
108MP0000432_abnormal_head_morphology0.83703489
109MP0004197_abnormal_fetal_growth/weight/0.83307541
110MP0002269_muscular_atrophy0.83134351
111MP0005248_abnormal_Harderian_gland0.83033866
112MP0005025_abnormal_response_to0.82639150
113MP0000383_abnormal_hair_follicle0.82280466
114MP0003315_abnormal_perineum_morphology0.82194219
115MP0000465_gastrointestinal_hemorrhage0.82149618
116MP0001299_abnormal_eye_distance/0.81787229
117MP0002419_abnormal_innate_immunity0.81776254
118MP0005621_abnormal_cell_physiology0.81425447
119MP0002095_abnormal_skin_pigmentation0.81209804
120MP0005464_abnormal_platelet_physiology0.81199835
121MP0002210_abnormal_sex_determination0.80875983
122MP0003448_altered_tumor_morphology0.80580873
123MP0000358_abnormal_cell_content/0.80421251
124MP0005275_abnormal_skin_tensile0.79837984
125MP0003755_abnormal_palate_morphology0.79311453
126MP0005384_cellular_phenotype0.79173417
127MP0005174_abnormal_tail_pigmentation0.78849003
128MP0002111_abnormal_tail_morphology0.78696662
129MP0002060_abnormal_skin_morphology0.78542029
130MP0001286_abnormal_eye_development0.77943606
131MP0001929_abnormal_gametogenesis0.77676042
132MP0000627_abnormal_mammary_gland0.77221518
133MP0006035_abnormal_mitochondrial_morpho0.77135406
134MP0009697_abnormal_copulation0.77059956
135MP0005501_abnormal_skin_physiology0.76285354
136MP0009053_abnormal_anal_canal0.75078052
137MP0005408_hypopigmentation0.73688487
138MP0005395_other_phenotype0.72951691
139MP0002405_respiratory_system_inflammati0.71586562
140MP0000467_abnormal_esophagus_morphology0.71559136
141MP0000647_abnormal_sebaceous_gland0.71204350
142MP0003935_abnormal_craniofacial_develop0.71042514
143MP0000477_abnormal_intestine_morphology0.70380283
144MP0001764_abnormal_homeostasis0.70339308
145MP0000749_muscle_degeneration0.69143351
146MP0005389_reproductive_system_phenotype0.68956614
147MP0004084_abnormal_cardiac_muscle0.68346453
148MP0003567_abnormal_fetal_cardiomyocyte0.67895911
149MP0000427_abnormal_hair_cycle0.65508220

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.22220950
2Degeneration of anterior horn cells (HP:0002398)4.22220950
3Thrombocytosis (HP:0001894)3.80442816
4Birth length less than 3rd percentile (HP:0003561)3.22943799
5Hypoplasia of the capital femoral epiphysis (HP:0003090)3.19128204
6Rhabdomyosarcoma (HP:0002859)3.18755510
7Poikiloderma (HP:0001029)3.18245398
8Chromsome breakage (HP:0040012)3.05722717
911 pairs of ribs (HP:0000878)3.04319548
10Papillary thyroid carcinoma (HP:0002895)2.93824528
11Agnosia (HP:0010524)2.91148085
12Spinal muscular atrophy (HP:0007269)2.84270793
13Embryonal renal neoplasm (HP:0011794)2.77548473
14Rough bone trabeculation (HP:0100670)2.75612567
15Nephroblastoma (Wilms tumor) (HP:0002667)2.74787396
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73566231
17Abnormality of chromosome stability (HP:0003220)2.70657885
18Reticulocytopenia (HP:0001896)2.70625322
19Entropion (HP:0000621)2.69893378
20Myelodysplasia (HP:0002863)2.63728940
21Abnormality of the preputium (HP:0100587)2.63185441
22Premature graying of hair (HP:0002216)2.56713155
23Increased nuchal translucency (HP:0010880)2.48259435
24Aplastic anemia (HP:0001915)2.46132728
25Oral leukoplakia (HP:0002745)2.45230159
26Deep philtrum (HP:0002002)2.39591287
27Medulloblastoma (HP:0002885)2.35403164
28Bone marrow hypocellularity (HP:0005528)2.34921720
29Right ventricular cardiomyopathy (HP:0011663)2.31969334
30Abnormality of the renal collecting system (HP:0004742)2.30755457
31Squamous cell carcinoma (HP:0002860)2.28537585
32Meckel diverticulum (HP:0002245)2.27853574
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.27628504
34Wrist flexion contracture (HP:0001239)2.27244418
35Microglossia (HP:0000171)2.26142065
36Duplicated collecting system (HP:0000081)2.25698714
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25547703
38Absent epiphyses (HP:0010577)2.25547703
39Ependymoma (HP:0002888)2.24317384
40Amaurosis fugax (HP:0100576)2.21957916
41Abnormality of the ileum (HP:0001549)2.21711031
42Tongue fasciculations (HP:0001308)2.20308508
43Septo-optic dysplasia (HP:0100842)2.20151248
44Blepharitis (HP:0000498)2.19855848
45Acute myeloid leukemia (HP:0004808)2.19373291
46Basal cell carcinoma (HP:0002671)2.17616115
47Absent thumb (HP:0009777)2.17208344
48Fibular aplasia (HP:0002990)2.16517067
49Cellular immunodeficiency (HP:0005374)2.15797867
50Ankyloglossia (HP:0010296)2.15636691
51Abnormality of glycolysis (HP:0004366)2.13877000
52Abnormal lung lobation (HP:0002101)2.13332880
53Trismus (HP:0000211)2.12435009
54Biliary tract neoplasm (HP:0100574)2.12424160
55Abnormal trabecular bone morphology (HP:0100671)2.10938287
56Missing ribs (HP:0000921)2.10142022
57Symptomatic seizures (HP:0011145)2.09473142
58Cortical dysplasia (HP:0002539)2.08128533
59IgA deficiency (HP:0002720)2.05260327
60Lymphoma (HP:0002665)2.05136355
61Neoplasm of the small intestine (HP:0100833)2.03432501
62Gonadotropin excess (HP:0000837)2.03318872
63Volvulus (HP:0002580)2.02588914
64Abnormality of cells of the erythroid lineage (HP:0012130)2.01485239
65T lymphocytopenia (HP:0005403)2.00879103
66IgM deficiency (HP:0002850)1.99525045
67Malignant gastrointestinal tract tumors (HP:0006749)1.96951119
68Gastrointestinal carcinoma (HP:0002672)1.96951119
69Colon cancer (HP:0003003)1.96907757
70Small intestinal stenosis (HP:0012848)1.96010414
71Duodenal stenosis (HP:0100867)1.96010414
72Increased serum pyruvate (HP:0003542)1.95969876
73Spastic diplegia (HP:0001264)1.95725511
74Cheilitis (HP:0100825)1.95418803
75Secondary amenorrhea (HP:0000869)1.94476180
76Thyroid carcinoma (HP:0002890)1.94454608
77Pallor (HP:0000980)1.93911627
78Neoplasm of the colon (HP:0100273)1.93701116
79Lymphopenia (HP:0001888)1.93089007
80Abnormality of cells of the lymphoid lineage (HP:0012140)1.92809242
81Pancytopenia (HP:0001876)1.92689617
82Abnormality of T cell number (HP:0011839)1.92164187
83Prominent metopic ridge (HP:0005487)1.92027267
84Deviation of the thumb (HP:0009603)1.91557205
85Abnormality of T cells (HP:0002843)1.91528212
86Type 2 muscle fiber atrophy (HP:0003554)1.91370286
87Selective tooth agenesis (HP:0001592)1.91239065
88Breast hypoplasia (HP:0003187)1.89770068
89Bifid tongue (HP:0010297)1.89672824
90Clubbing of toes (HP:0100760)1.87893123
91Atrophy/Degeneration involving motor neurons (HP:0007373)1.87284867
92Abnormality of the duodenum (HP:0002246)1.86713730
93Abnormal biliary tract morphology (HP:0012440)1.86599695
94Hypoglycemic seizures (HP:0002173)1.86346595
95Cafe-au-lait spot (HP:0000957)1.85651262
96Sloping forehead (HP:0000340)1.85411759
97Macrocytic anemia (HP:0001972)1.84971238
98Curly hair (HP:0002212)1.84751966
99Abnormality of the astrocytes (HP:0100707)1.84454314
100Astrocytoma (HP:0009592)1.84454314
101Abnormality of DNA repair (HP:0003254)1.84289255
102Abnormal number of erythroid precursors (HP:0012131)1.84249807
103Cutaneous melanoma (HP:0012056)1.83289649
104Absent radius (HP:0003974)1.82640023
105Recurrent bronchitis (HP:0002837)1.82317470
106Abnormal umbilical cord blood vessels (HP:0011403)1.82257280
107Single umbilical artery (HP:0001195)1.82257280
108Abnormality of the fetal cardiovascular system (HP:0010948)1.82257280
109Ectopic kidney (HP:0000086)1.82103351
110High pitched voice (HP:0001620)1.81789750
111Exercise-induced muscle cramps (HP:0003710)1.81331310
112Short humerus (HP:0005792)1.81244997
113Abnormalities of placenta or umbilical cord (HP:0001194)1.81179243
114Facial cleft (HP:0002006)1.80636448
115Muscle fibrillation (HP:0010546)1.80241736
116Uterine neoplasm (HP:0010784)1.79712301
117Increased mean platelet volume (HP:0011877)1.79060864
118Progressive external ophthalmoplegia (HP:0000590)1.78182736
119High anterior hairline (HP:0009890)1.77784790
120Progressive sensorineural hearing impairment (HP:0000408)1.77668602
121Freckling (HP:0001480)1.77570042
122Abnormality of nail color (HP:0100643)1.76474923
123Ovarian neoplasm (HP:0100615)1.76355493
124Pancreatic islet-cell hyperplasia (HP:0004510)1.75748386
125Bifid uvula (HP:0000193)1.75732985
126Premature ovarian failure (HP:0008209)1.74232421
127Preauricular skin tag (HP:0000384)1.73935537
128Glioma (HP:0009733)1.73878663
129Abnormality of methionine metabolism (HP:0010901)1.73801345
130Proximal placement of thumb (HP:0009623)1.73618297
131Abnormality of the umbilical cord (HP:0010881)1.73018630
132Neoplasm of the pancreas (HP:0002894)1.72913145
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72742773
134Choanal atresia (HP:0000453)1.72267718
135Abnormal hair whorl (HP:0010721)1.71518635
136Optic nerve coloboma (HP:0000588)1.71214040
137Granulocytopenia (HP:0001913)1.71152216
138Aplasia/hypoplasia of the humerus (HP:0006507)1.70941505
139Microretrognathia (HP:0000308)1.70725328
140Abnormality of oral frenula (HP:0000190)1.70512259
141Abnormality of eosinophils (HP:0001879)1.69788349
142Long clavicles (HP:0000890)1.69239240
143Abnormal platelet volume (HP:0011876)1.68757688
144Multiple enchondromatosis (HP:0005701)1.68721060
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68436653
146Delayed closure of the anterior fontanelle (HP:0001476)1.68266108
147Leiomyosarcoma (HP:0100243)1.68018859
148Uterine leiomyosarcoma (HP:0002891)1.68018859
149Neoplasm of the rectum (HP:0100743)1.67482908
150Skull defect (HP:0001362)1.66883898
151Patellar aplasia (HP:0006443)1.66654536
152Natal tooth (HP:0000695)1.66340734
153Eosinophilia (HP:0001880)1.65995208
154Muscle fiber atrophy (HP:0100295)1.65406686
155Neoplasm of striated muscle (HP:0009728)1.65269164
156Onycholysis (HP:0001806)1.64616489
157Chronic diarrhea (HP:0002028)1.63441283
158Type I transferrin isoform profile (HP:0003642)1.63362059
159Shoulder girdle muscle weakness (HP:0003547)1.62891460
160Abnormality of the septum pellucidum (HP:0007375)1.62525759
161Leukopenia (HP:0001882)1.62491172
162Tetraparesis (HP:0002273)1.62200954
163Absent forearm bone (HP:0003953)1.62150040
164Aplasia involving forearm bones (HP:0009822)1.62150040
165Abnormal spermatogenesis (HP:0008669)1.61995996
166Breast carcinoma (HP:0003002)1.61813383
167Abnormality of the carotid arteries (HP:0005344)1.61415882
168Aplasia/Hypoplasia of the sternum (HP:0006714)1.60702619
169Lower limb hyperreflexia (HP:0002395)1.60557246
170Aplasia cutis congenita (HP:0001057)1.59740496
171Hypoplastic pelvis (HP:0008839)1.58623048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.56112764
2CDC73.42867761
3EIF2AK12.83260993
4BUB12.58085900
5ZAK2.44282805
6WEE12.34856095
7FLT32.26660386
8EPHA22.11421410
9PASK2.10314825
10SRPK11.97964137
11VRK11.93720625
12STK38L1.91865357
13MAP3K141.91602604
14RPS6KA41.90455512
15STK101.89156151
16SCYL21.77843538
17MAP2K31.77013400
18MAP4K11.76350396
19TRIM281.74642693
20PKN21.73559471
21MAP3K101.72198922
22CDK121.67877243
23NME21.64384753
24RPS6KB21.63411180
25MET1.62287409
26TTK1.59278380
27MST1R1.54830267
28CDK71.54680852
29EIF2AK31.53219419
30AURKB1.49900157
31ATR1.48659420
32IRAK41.44697167
33NEK21.44641611
34BRD41.41772362
35ERBB41.41562883
36STK161.39196163
37JAK31.38631550
38PAK41.37484793
39STK241.36266987
40PLK31.31696250
41ACVR1B1.30481019
42KIT1.29906907
43PLK11.25962136
44TLK11.23957428
45PNCK1.23045664
46STK31.22560874
47TXK1.18321840
48NEK91.12039536
49MAP3K31.11245918
50PDGFRA1.10214084
51BCR1.08182720
52MAP3K81.07431473
53PLK21.03721143
54MST41.02565328
55PIK3CG1.01363218
56ZAP700.99979992
57NEK60.99929143
58TESK10.97374547
59CHUK0.96175594
60CSF1R0.95638431
61FGFR10.95295832
62YES10.94993524
63FRK0.94652010
64TYK20.92654556
65DYRK30.92516910
66TGFBR20.91013676
67CDK40.90157778
68PLK40.89997544
69TAF10.88895218
70MKNK10.88824097
71CAMK1G0.88366168
72TGFBR10.87522889
73TNIK0.86883682
74IKBKB0.84793171
75PTK20.84161896
76BRSK20.83857493
77ATM0.80860299
78BMPR1B0.80507208
79EIF2AK20.79022015
80BMX0.78437148
81CHEK10.76945209
82RPS6KA60.76490090
83PIM10.72717005
84BRSK10.72401519
85MELK0.72351505
86CCNB10.71020173
87STK40.70420591
88PBK0.67831013
89EEF2K0.67646015
90AURKA0.66014219
91BTK0.65520417
92CDK80.63802771
93FER0.63397489
94PIM20.62142326
95PDK20.60009389
96VRK20.59495646
97ALK0.59017060
98CHEK20.58139665
99LCK0.58030522
100ERBB30.57674759
101CDK20.57230566
102AKT20.56621116
103BCKDK0.56104518
104CSNK2A20.55238948
105CDK10.54838131
106CSNK2A10.54776657
107RPS6KC10.54388226
108RPS6KL10.54388226
109NLK0.54001259
110FGR0.53389859
111CDK60.51832408
112AKT30.51759852
113TBK10.51199517
114RPS6KB10.50652539
115NUAK10.49845635
116TESK20.49083825
117CLK10.48899570
118TAOK30.48871206
119CSNK1G10.48539158
120BRAF0.48355069
121PDGFRB0.48263270
122KSR10.47596238
123SMG10.46774777
124MAP3K90.46700292
125MAP3K120.46484866
126OBSCN0.46453037
127MKNK20.45122698
128TEC0.44123082
129ERN10.43385376
130MTOR0.43196015
131RPS6KA50.41942104
132TTN0.41839159
133LYN0.41553475
134PAK20.41531508
135KSR20.41431464
136LATS20.41139946
137DYRK1B0.40859565
138NEK10.40487790
139LATS10.40323039
140MAP2K60.39136429
141EPHA30.38718919
142MAP3K110.38601508

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.88550866
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55198703
3Mismatch repair_Homo sapiens_hsa034303.44092819
4One carbon pool by folate_Homo sapiens_hsa006703.17376587
5RNA polymerase_Homo sapiens_hsa030202.72163496
6Base excision repair_Homo sapiens_hsa034102.70353162
7Proteasome_Homo sapiens_hsa030502.56784561
8Ribosome_Homo sapiens_hsa030102.56669530
9Spliceosome_Homo sapiens_hsa030402.53088726
10RNA transport_Homo sapiens_hsa030132.51949013
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49653501
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47237496
13Nucleotide excision repair_Homo sapiens_hsa034202.30043664
14Homologous recombination_Homo sapiens_hsa034402.23384004
15Fanconi anemia pathway_Homo sapiens_hsa034602.22529615
16RNA degradation_Homo sapiens_hsa030182.01761446
17Cell cycle_Homo sapiens_hsa041102.01256879
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01129732
19Pyrimidine metabolism_Homo sapiens_hsa002401.92691725
20Non-homologous end-joining_Homo sapiens_hsa034501.72325901
21Basal transcription factors_Homo sapiens_hsa030221.70975380
22Adherens junction_Homo sapiens_hsa045201.60733631
23Propanoate metabolism_Homo sapiens_hsa006401.60667102
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58407302
25Antigen processing and presentation_Homo sapiens_hsa046121.57414577
26Steroid biosynthesis_Homo sapiens_hsa001001.50219619
27Carbon metabolism_Homo sapiens_hsa012001.47355183
28p53 signaling pathway_Homo sapiens_hsa041151.44822146
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43307736
30mRNA surveillance pathway_Homo sapiens_hsa030151.41896102
31Pyruvate metabolism_Homo sapiens_hsa006201.33646133
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33092357
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.26052396
34Purine metabolism_Homo sapiens_hsa002301.24897194
35Epstein-Barr virus infection_Homo sapiens_hsa051691.23725746
36Protein export_Homo sapiens_hsa030601.19042849
37Primary immunodeficiency_Homo sapiens_hsa053401.18718502
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17091588
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15783863
40Legionellosis_Homo sapiens_hsa051341.13049521
41Herpes simplex infection_Homo sapiens_hsa051681.04941297
42Fatty acid elongation_Homo sapiens_hsa000621.03514821
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03389238
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.00648646
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.00427253
46Renin-angiotensin system_Homo sapiens_hsa046140.99708378
47Viral carcinogenesis_Homo sapiens_hsa052030.99138533
48Oocyte meiosis_Homo sapiens_hsa041140.96509138
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.95392268
50Glutathione metabolism_Homo sapiens_hsa004800.94196703
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.93134201
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92425895
53Selenocompound metabolism_Homo sapiens_hsa004500.91995163
54Measles_Homo sapiens_hsa051620.91969329
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91150566
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90466220
57Apoptosis_Homo sapiens_hsa042100.90331152
58Pentose phosphate pathway_Homo sapiens_hsa000300.90123573
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90040559
60Systemic lupus erythematosus_Homo sapiens_hsa053220.88411614
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87088990
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84233034
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.84120764
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82420114
65Lysine degradation_Homo sapiens_hsa003100.80286955
66Galactose metabolism_Homo sapiens_hsa000520.79362488
67Folate biosynthesis_Homo sapiens_hsa007900.78561085
68Acute myeloid leukemia_Homo sapiens_hsa052210.77055589
69Hematopoietic cell lineage_Homo sapiens_hsa046400.77036856
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75995413
71HTLV-I infection_Homo sapiens_hsa051660.75327171
72Proteoglycans in cancer_Homo sapiens_hsa052050.73071170
73Small cell lung cancer_Homo sapiens_hsa052220.71851239
74Fatty acid metabolism_Homo sapiens_hsa012120.70145706
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67524218
76Fructose and mannose metabolism_Homo sapiens_hsa000510.67271540
77B cell receptor signaling pathway_Homo sapiens_hsa046620.64273135
78Leishmaniasis_Homo sapiens_hsa051400.63549230
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63105307
80Arginine biosynthesis_Homo sapiens_hsa002200.60671523
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60361768
82Tight junction_Homo sapiens_hsa045300.59327762
83Hippo signaling pathway_Homo sapiens_hsa043900.58941856
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58798177
85MicroRNAs in cancer_Homo sapiens_hsa052060.58490793
86Biosynthesis of amino acids_Homo sapiens_hsa012300.57738551
87Hepatitis B_Homo sapiens_hsa051610.57547983
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57132818
89ECM-receptor interaction_Homo sapiens_hsa045120.56453632
90T cell receptor signaling pathway_Homo sapiens_hsa046600.55990493
91Vitamin digestion and absorption_Homo sapiens_hsa049770.55208956
92Colorectal cancer_Homo sapiens_hsa052100.54867962
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53690165
94Influenza A_Homo sapiens_hsa051640.53372291
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52523535
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48514133
97Shigellosis_Homo sapiens_hsa051310.48285603
98Wnt signaling pathway_Homo sapiens_hsa043100.48255200
99TNF signaling pathway_Homo sapiens_hsa046680.46885516
100N-Glycan biosynthesis_Homo sapiens_hsa005100.46799530
101TGF-beta signaling pathway_Homo sapiens_hsa043500.46458737
102Toxoplasmosis_Homo sapiens_hsa051450.45941292
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45346684
104Chemical carcinogenesis_Homo sapiens_hsa052040.44702769
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43237440
106Thyroid cancer_Homo sapiens_hsa052160.42973160
107Sulfur metabolism_Homo sapiens_hsa009200.42239473
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41562308
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41302768
110Focal adhesion_Homo sapiens_hsa045100.40532034
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38757483
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.38727308
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37437647
114Prostate cancer_Homo sapiens_hsa052150.37087723
115Chronic myeloid leukemia_Homo sapiens_hsa052200.36789454
116Starch and sucrose metabolism_Homo sapiens_hsa005000.36698650
117Endometrial cancer_Homo sapiens_hsa052130.33991231
118Sphingolipid metabolism_Homo sapiens_hsa006000.33942625
119Pertussis_Homo sapiens_hsa051330.32896245
120Fatty acid degradation_Homo sapiens_hsa000710.32795974
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.32390724
122Metabolic pathways_Homo sapiens_hsa011000.31840743
123Bladder cancer_Homo sapiens_hsa052190.31039048
124Basal cell carcinoma_Homo sapiens_hsa052170.30772222
125Hedgehog signaling pathway_Homo sapiens_hsa043400.29819779
126Pancreatic cancer_Homo sapiens_hsa052120.29582332
127Fat digestion and absorption_Homo sapiens_hsa049750.29147008
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28624379
129Arachidonic acid metabolism_Homo sapiens_hsa005900.28158080
130Viral myocarditis_Homo sapiens_hsa054160.27823978
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27699174
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25299844
133Alcoholism_Homo sapiens_hsa050340.24576246
134Vitamin B6 metabolism_Homo sapiens_hsa007500.24457600
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23362374
136Allograft rejection_Homo sapiens_hsa053300.22428491
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22156801
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.21707792
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21581577
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21468057

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