EFNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04857320
2L-phenylalanine catabolic process (GO:0006559)6.04857320
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.84270996
4L-phenylalanine metabolic process (GO:0006558)5.84270996
5aromatic amino acid family catabolic process (GO:0009074)4.93665937
6negative regulation of complement activation (GO:0045916)4.80367256
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44686621
8glyoxylate metabolic process (GO:0046487)4.43689353
9negative regulation of fibrinolysis (GO:0051918)4.36063925
10regulation of fibrinolysis (GO:0051917)4.33481849
11very-low-density lipoprotein particle assembly (GO:0034379)4.31090662
12high-density lipoprotein particle remodeling (GO:0034375)4.26235188
13bile acid biosynthetic process (GO:0006699)4.24868209
14indole-containing compound catabolic process (GO:0042436)4.17541834
15indolalkylamine catabolic process (GO:0046218)4.17541834
16tryptophan catabolic process (GO:0006569)4.17541834
17plasma lipoprotein particle assembly (GO:0034377)4.14563469
18desmosome organization (GO:0002934)4.13803115
19regulation of protein activation cascade (GO:2000257)4.12993555
20peptidyl-glutamic acid carboxylation (GO:0017187)4.10736828
21protein carboxylation (GO:0018214)4.10736828
22sulfur amino acid catabolic process (GO:0000098)4.02777785
23kynurenine metabolic process (GO:0070189)4.00772089
24tryptophan metabolic process (GO:0006568)3.96964447
25triglyceride homeostasis (GO:0070328)3.96642799
26acylglycerol homeostasis (GO:0055090)3.96642799
27positive regulation of lipoprotein lipase activity (GO:0051006)3.94108251
28positive regulation of triglyceride lipase activity (GO:0061365)3.94108251
29regulation of triglyceride catabolic process (GO:0010896)3.91180293
30low-density lipoprotein particle remodeling (GO:0034374)3.89305106
31regulation of complement activation (GO:0030449)3.86429469
32endothelium development (GO:0003158)3.86172875
33epoxygenase P450 pathway (GO:0019373)3.82750183
34reverse cholesterol transport (GO:0043691)3.78520413
35fibrinolysis (GO:0042730)3.77142370
36complement activation, alternative pathway (GO:0006957)3.76230754
37cysteine metabolic process (GO:0006534)3.72867759
38protein-lipid complex assembly (GO:0065005)3.71773025
39plasma lipoprotein particle organization (GO:0071827)3.69358163
40urea metabolic process (GO:0019627)3.68631177
41urea cycle (GO:0000050)3.68631177
42amino-acid betaine metabolic process (GO:0006577)3.66314338
43complement activation, classical pathway (GO:0006958)3.64031836
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62881146
45bile acid and bile salt transport (GO:0015721)3.62607776
46bile acid metabolic process (GO:0008206)3.62319515
47regulation of cholesterol esterification (GO:0010872)3.60022475
48regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.59718342
49serine family amino acid catabolic process (GO:0009071)3.59533272
50phospholipid efflux (GO:0033700)3.57874300
51aromatic amino acid family metabolic process (GO:0009072)3.57423091
52negative regulation of humoral immune response (GO:0002921)3.54604780
53cellular glucuronidation (GO:0052695)3.54212770
54positive regulation of extracellular matrix organization (GO:1903055)3.53684230
55alpha-linolenic acid metabolic process (GO:0036109)3.51333619
56intestinal absorption (GO:0050892)3.50452692
57protein-lipid complex remodeling (GO:0034368)3.49546208
58macromolecular complex remodeling (GO:0034367)3.49546208
59plasma lipoprotein particle remodeling (GO:0034369)3.49546208
60protein-lipid complex subunit organization (GO:0071825)3.48757636
61positive regulation of respiratory burst (GO:0060267)3.46795553
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44405919
63negative regulation of lipase activity (GO:0060192)3.44352960
64arginine metabolic process (GO:0006525)3.43187007
65hemidesmosome assembly (GO:0031581)3.42606274
66nitrogen cycle metabolic process (GO:0071941)3.40035809
67homocysteine metabolic process (GO:0050667)3.38406864
68negative regulation of hemostasis (GO:1900047)3.37897071
69negative regulation of blood coagulation (GO:0030195)3.37897071
70lymph vessel development (GO:0001945)3.37209496
71regulation of bile acid biosynthetic process (GO:0070857)3.36335887
72blood coagulation, intrinsic pathway (GO:0007597)3.33755939
73plasma lipoprotein particle clearance (GO:0034381)3.33298371
74tyrosine metabolic process (GO:0006570)3.33259864
75cholesterol homeostasis (GO:0042632)3.32275076
76regulation of cholesterol homeostasis (GO:2000188)3.31887369
77complement activation (GO:0006956)3.29875092
78alpha-amino acid catabolic process (GO:1901606)3.29697050
79sterol homeostasis (GO:0055092)3.25941513
80drug catabolic process (GO:0042737)3.24414165
81negative regulation of protein activation cascade (GO:2000258)3.22961443
82regulation of apoptotic cell clearance (GO:2000425)3.22146747
83exocrine pancreas development (GO:0031017)3.21133042
84uronic acid metabolic process (GO:0006063)3.18603489
85glucuronate metabolic process (GO:0019585)3.18603489
86heme transport (GO:0015886)3.18198904
87negative regulation of coagulation (GO:0050819)3.15291547
88cellular biogenic amine catabolic process (GO:0042402)3.15185892
89amine catabolic process (GO:0009310)3.15185892
90regulation of humoral immune response (GO:0002920)3.14605073
91cholesterol efflux (GO:0033344)3.13245055
92regulation of respiratory burst (GO:0060263)3.12787077
93negative regulation of wound healing (GO:0061045)3.12024995
94ethanol oxidation (GO:0006069)3.10767636
95Rap protein signal transduction (GO:0032486)3.10635836
96lysine metabolic process (GO:0006553)3.09519595
97lysine catabolic process (GO:0006554)3.09519595
98transcytosis (GO:0045056)3.08224874
99cellular ketone body metabolic process (GO:0046950)3.07803645
100flavonoid metabolic process (GO:0009812)3.07673430
101opsonization (GO:0008228)3.06670100
102regulation of cholesterol biosynthetic process (GO:0045540)3.06409954
103calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.04407867
104negative regulation of sterol transport (GO:0032372)3.03641406
105negative regulation of cholesterol transport (GO:0032375)3.03641406
106cellular amino acid catabolic process (GO:0009063)3.02486340
107proline metabolic process (GO:0006560)3.01104067
108protein activation cascade (GO:0072376)2.99908737
109surfactant homeostasis (GO:0043129)2.99706500
110peptidyl-tyrosine autophosphorylation (GO:0038083)2.99479148
111positive regulation of steroid metabolic process (GO:0045940)2.99279779
112primary alcohol catabolic process (GO:0034310)2.96559351
113drug transmembrane transport (GO:0006855)2.96165853
114acute inflammatory response (GO:0002526)2.94528260
115regulation of plasminogen activation (GO:0010755)2.92226763
116aldehyde catabolic process (GO:0046185)2.92128733
117transepithelial transport (GO:0070633)2.91042107
118ethanol metabolic process (GO:0006067)2.90900218
119carnitine metabolic process (GO:0009437)2.89987207
120intestinal cholesterol absorption (GO:0030299)2.89471552
121fatty acid elongation (GO:0030497)2.88339449
122exogenous drug catabolic process (GO:0042738)2.87979034
123coenzyme catabolic process (GO:0009109)2.87449593
124acute-phase response (GO:0006953)2.87282522
125benzene-containing compound metabolic process (GO:0042537)2.85469960
126basement membrane organization (GO:0071711)2.85066212
127lipoprotein metabolic process (GO:0042157)2.84420573
128glycine metabolic process (GO:0006544)2.83532019
129indolalkylamine metabolic process (GO:0006586)2.82400999
130urate metabolic process (GO:0046415)2.82051902
131drug metabolic process (GO:0017144)2.81963659
132fatty acid beta-oxidation (GO:0006635)2.80959664
133gap junction assembly (GO:0016264)2.79502950
134L-ascorbic acid metabolic process (GO:0019852)2.79078886
135multicellular organismal water homeostasis (GO:0050891)2.76269869
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.73620201
137regulation of cholesterol metabolic process (GO:0090181)2.73366956
138sterol transport (GO:0015918)2.68132256
139cholesterol transport (GO:0030301)2.68132256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.68971869
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.53734637
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.48569866
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.77684189
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67906791
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.42906030
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.33512461
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.11904055
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.50782658
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.26748776
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.81833779
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.80616801
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.57705044
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52902632
15* ESR2_21235772_ChIP-Seq_MCF-7_Human2.43521925
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.40833168
17CLOCK_20551151_ChIP-Seq_293T_Human2.19306878
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16234677
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91829139
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90599812
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83877704
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82869162
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79241102
24SOX2_20726797_ChIP-Seq_SW620_Human1.76791790
25ZNF263_19887448_ChIP-Seq_K562_Human1.75841967
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.73990991
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.67940825
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58610897
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47745345
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39738573
31* GATA4_25053715_ChIP-Seq_YYC3_Human1.35457762
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.33365466
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31598177
34* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30985208
35* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30089754
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29587682
37* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28652012
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27949789
39* FOXO3_23340844_ChIP-Seq_DLD1_Human1.26842809
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26435453
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26367577
42* TCF4_18268006_ChIP-ChIP_LS174T_Human1.24907195
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23961067
44* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23212123
45GATA1_22025678_ChIP-Seq_K562_Human1.20869782
46AHR_22903824_ChIP-Seq_MCF-7_Human1.18188509
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17503539
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13545630
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13545630
50* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12203054
51EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10210105
52* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09590934
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.08233058
54* FOXA1_25552417_ChIP-Seq_VCAP_Human1.06647219
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04874879
56* CJUN_26792858_Chip-Seq_BT549_Human1.03845387
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03694450
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03128322
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02626678
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00497916
61* RACK7_27058665_Chip-Seq_MCF-7_Human0.99171874
62EGR1_19032775_ChIP-ChIP_M12_Human0.98778430
63KLF5_25053715_ChIP-Seq_YYC3_Human0.98582035
64* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96128932
65NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95703692
66* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94884573
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93936765
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93406171
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89399393
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88325225
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87681076
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87338987
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87338987
74* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86728528
75* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86486128
76* GATA3_24758297_ChIP-Seq_MCF-7_Human0.85210283
77* CREB1_26743006_Chip-Seq_LNCaP_Human0.84946802
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84337882
79TBX20_22080862_ChIP-Seq_HEART_Mouse0.83792128
80TBX20_22328084_ChIP-Seq_HEART_Mouse0.83792128
81* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82918257
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81898582
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81898582
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81898582
85AR_21909140_ChIP-Seq_LNCAP_Human0.80971983
86HTT_18923047_ChIP-ChIP_STHdh_Human0.79803496
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79505421
88* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79008859
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77965906
90* GATA6_25053715_ChIP-Seq_YYC3_Human0.77949812
91* ELK3_25401928_ChIP-Seq_HUVEC_Human0.76381405
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76002322
93* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74576006
94TP63_23658742_ChIP-Seq_EP156T_Human0.74209666
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73807552
96* ATF3_27146783_Chip-Seq_COLON_Human0.71697451
97* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71601855
98* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71409134
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71148932
100* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71031570
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71006221
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70291434
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69824573
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69573071
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68543579
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.68208642
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67889512
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66646455
109CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65824132
110* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65389767
111* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.65274554
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.64389914
113* CTCF_27219007_Chip-Seq_Bcells_Human0.63934749
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63547576
115EED_16625203_ChIP-ChIP_MESCs_Mouse0.63305104
116* RUNX1_27514584_Chip-Seq_MCF-7_Human0.63241440
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.63066302
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.62289362
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.61845088
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.60913250
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60562708
122* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60371040
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60005526
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59596881
125LXR_22292898_ChIP-Seq_THP-1_Human0.59284074
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.59228362
127AR_20517297_ChIP-Seq_VCAP_Human0.58986279
128* TP63_22573176_ChIP-Seq_HFKS_Human0.58648066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.81622184
2MP0002139_abnormal_hepatobiliary_system5.48840078
3MP0005085_abnormal_gallbladder_physiolo4.66212104
4MP0005365_abnormal_bile_salt3.96032585
5MP0005670_abnormal_white_adipose3.79823879
6MP0008875_abnormal_xenobiotic_pharmacok3.64606709
7MP0010368_abnormal_lymphatic_system3.63662632
8MP0003806_abnormal_nucleotide_metabolis3.02019843
9MP0003191_abnormal_cellular_cholesterol2.60064173
10MP0003252_abnormal_bile_duct2.59728339
11MP0001666_abnormal_nutrient_absorption2.49031313
12MP0001879_abnormal_lymphatic_vessel2.40071231
13MP0010329_abnormal_lipoprotein_level2.37545123
14MP0005083_abnormal_biliary_tract2.36893308
15MP0002796_impaired_skin_barrier2.36633298
16MP0009840_abnormal_foam_cell2.27068900
17MP0009379_abnormal_foot_pigmentation2.10086092
18MP0004019_abnormal_vitamin_homeostasis2.06236929
19MP0004272_abnormal_basement_membrane2.01536700
20MP0005167_abnormal_blood-brain_barrier2.00809154
21MP0005332_abnormal_amino_acid1.95794973
22MP0002138_abnormal_hepatobiliary_system1.93525007
23MP0002876_abnormal_thyroid_physiology1.91854148
24MP0003705_abnormal_hypodermis_morpholog1.82461320
25MP0005451_abnormal_body_composition1.81868345
26MP0003195_calcinosis1.79046984
27MP0010234_abnormal_vibrissa_follicle1.70326181
28MP0002254_reproductive_system_inflammat1.67858853
29MP0000566_synostosis1.67798918
30MP0009697_abnormal_copulation1.61321252
31MP0004381_abnormal_hair_follicle1.53017491
32MP0002118_abnormal_lipid_homeostasis1.43242609
33MP0005409_darkened_coat_color1.35067498
34MP0000003_abnormal_adipose_tissue1.33951972
35MP0009780_abnormal_chondrocyte_physiolo1.33147910
36MP0002060_abnormal_skin_morphology1.31787380
37MP0005275_abnormal_skin_tensile1.31395980
38MP0002098_abnormal_vibrissa_morphology1.31052612
39MP0000383_abnormal_hair_follicle1.30915418
40MP0010678_abnormal_skin_adnexa1.30208430
41MP0003724_increased_susceptibility_to1.28474662
42MP0003941_abnormal_skin_development1.28451129
43MP0005501_abnormal_skin_physiology1.28389771
44MP0003868_abnormal_feces_composition1.28201251
45MP0000609_abnormal_liver_physiology1.27293188
46MP0003183_abnormal_peptide_metabolism1.24473019
47MP0000762_abnormal_tongue_morphology1.19652345
48MP0003123_paternal_imprinting1.18907771
49MP0005058_abnormal_lysosome_morphology1.18801083
50MP0006054_spinal_hemorrhage1.17877632
51MP0005319_abnormal_enzyme/_coenzyme1.17813239
52MP0005375_adipose_tissue_phenotype1.17358192
53MP0003453_abnormal_keratinocyte_physiol1.17315301
54MP0009384_cardiac_valve_regurgitation1.15609241
55MP0004782_abnormal_surfactant_physiolog1.15371166
56MP0005408_hypopigmentation1.14153772
57MP0009643_abnormal_urine_homeostasis1.13961205
58MP0008004_abnormal_stomach_pH1.13910209
59MP0003011_delayed_dark_adaptation1.08854272
60MP0005666_abnormal_adipose_tissue1.08235681
61MP0003566_abnormal_cell_adhesion1.08024981
62MP0003950_abnormal_plasma_membrane1.02555394
63MP0001764_abnormal_homeostasis1.01881819
64MP0002909_abnormal_adrenal_gland1.01674428
65MP0000579_abnormal_nail_morphology1.00204269
66MP0001216_abnormal_epidermal_layer0.99170645
67MP0000647_abnormal_sebaceous_gland0.92466810
68MP0001851_eye_inflammation0.92041108
69MP0003828_pulmonary_edema0.91726148
70MP0002136_abnormal_kidney_physiology0.90527832
71MP0004043_abnormal_pH_regulation0.88428291
72MP0000013_abnormal_adipose_tissue0.88250954
73MP0005084_abnormal_gallbladder_morpholo0.88136794
74MP0006138_congestive_heart_failure0.86898240
75MP0002166_altered_tumor_susceptibility0.86088425
76MP0005023_abnormal_wound_healing0.85722885
77MP0010771_integument_phenotype0.85024782
78MP0000377_abnormal_hair_follicle0.84746092
79MP0000537_abnormal_urethra_morphology0.84539961
80MP0004264_abnormal_extraembryonic_tissu0.83833865
81MP0000678_abnormal_parathyroid_gland0.83174452
82MP0003943_abnormal_hepatobiliary_system0.82550327
83MP0001542_abnormal_bone_strength0.79719642
84MP0005410_abnormal_fertilization0.79056503
85MP0001765_abnormal_ion_homeostasis0.78367553
86MP0003186_abnormal_redox_activity0.78059834
87MP0000467_abnormal_esophagus_morphology0.77576279
88MP0001873_stomach_inflammation0.77332757
89MP0002295_abnormal_pulmonary_circulatio0.75834653
90MP0000538_abnormal_urinary_bladder0.75163785
91MP0002282_abnormal_trachea_morphology0.74367463
92MP0000465_gastrointestinal_hemorrhage0.73953976
93MP0000427_abnormal_hair_cycle0.72628254
94MP0003315_abnormal_perineum_morphology0.72121458
95MP0004084_abnormal_cardiac_muscle0.71370680
96MP0005395_other_phenotype0.70375859
97MP0005636_abnormal_mineral_homeostasis0.70100009
98MP0000249_abnormal_blood_vessel0.68889416
99MP0000598_abnormal_liver_morphology0.68797552
100MP0005647_abnormal_sex_gland0.68685722
101MP0003638_abnormal_response/metabolism_0.67716793
102MP0001243_abnormal_dermal_layer0.67581584
103MP0000767_abnormal_smooth_muscle0.67539901
104MP0002168_other_aberrant_phenotype0.67471462
105MP0000613_abnormal_salivary_gland0.67349364
106MP0003878_abnormal_ear_physiology0.67306846
107MP0005377_hearing/vestibular/ear_phenot0.67306846
108MP0000230_abnormal_systemic_arterial0.67257342
109MP0005584_abnormal_enzyme/coenzyme_acti0.66216073
110MP0005595_abnormal_vascular_smooth0.65388723
111MP0005330_cardiomyopathy0.65357161
112MP0003718_maternal_effect0.65028895
113MP0010352_gastrointestinal_tract_polyps0.64998113
114MP0002089_abnormal_postnatal_growth/wei0.64892179
115MP0002132_abnormal_respiratory_system0.64842674
116MP0000627_abnormal_mammary_gland0.64105926
117MP0005165_increased_susceptibility_to0.63734919
118MP0001756_abnormal_urination0.63457474
119MP0009642_abnormal_blood_homeostasis0.63159032
120MP0002249_abnormal_larynx_morphology0.62956152
121MP0009764_decreased_sensitivity_to0.62612235
122MP0005334_abnormal_fat_pad0.62357106
123MP0001346_abnormal_lacrimal_gland0.61579978
124MP0005164_abnormal_response_to0.60019469
125MP0002896_abnormal_bone_mineralization0.59464990
126MP0009763_increased_sensitivity_to0.59423785
127MP0005385_cardiovascular_system_phenoty0.59354888
128MP0001544_abnormal_cardiovascular_syste0.59354888
129MP0001270_distended_abdomen0.58841136
130MP0004883_abnormal_blood_vessel0.58762472
131MP0001614_abnormal_blood_vessel0.58347397
132MP0000163_abnormal_cartilage_morphology0.57916207
133MP0005076_abnormal_cell_differentiation0.55661343
134MP0009931_abnormal_skin_appearance0.55528859
135MP0005508_abnormal_skeleton_morphology0.54506202
136MP0000477_abnormal_intestine_morphology0.53782657
137MP0000462_abnormal_digestive_system0.53707580
138MP0003953_abnormal_hormone_level0.50854830

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.89589008
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.79510182
3Intrahepatic cholestasis (HP:0001406)5.74198107
4Glomerulonephritis (HP:0000099)4.83652766
5Prolonged partial thromboplastin time (HP:0003645)4.77352724
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.75341438
7Xanthomatosis (HP:0000991)4.68133457
8Systemic lupus erythematosus (HP:0002725)4.45151020
9Hypobetalipoproteinemia (HP:0003563)4.21999146
10Hyperlipoproteinemia (HP:0010980)3.66289034
11Hypolipoproteinemia (HP:0010981)3.47578844
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43778352
13Complement deficiency (HP:0004431)3.43069742
14Right ventricular cardiomyopathy (HP:0011663)3.39984927
15Hemorrhage of the eye (HP:0011885)3.38475445
16Fat malabsorption (HP:0002630)3.34066561
17Pancreatic islet-cell hyperplasia (HP:0004510)3.33158137
18Hypoalphalipoproteinemia (HP:0003233)3.31060653
19Joint hemorrhage (HP:0005261)3.30830012
20Hypoglycemic seizures (HP:0002173)3.25085277
21Abnormality of the intrinsic pathway (HP:0010989)3.24943145
22Hyperammonemia (HP:0001987)3.24806528
23Nephritis (HP:0000123)3.14740672
24Abnormality of the common coagulation pathway (HP:0010990)3.14733904
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14013126
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04532394
27Hyperglycinemia (HP:0002154)2.98429916
28Hyperglycinuria (HP:0003108)2.96811140
29Abnormal tarsal ossification (HP:0008369)2.91767521
30Abnormality of glycine metabolism (HP:0010895)2.88855878
31Abnormality of serine family amino acid metabolism (HP:0010894)2.88855878
32Mitral stenosis (HP:0001718)2.86524253
33Epidermoid cyst (HP:0200040)2.85991592
34Vascular calcification (HP:0004934)2.81861940
35Abnormality of methionine metabolism (HP:0010901)2.81511283
36Hypoglycemic coma (HP:0001325)2.79233584
37Growth hormone excess (HP:0000845)2.77451804
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.71584455
39Ketosis (HP:0001946)2.70683929
40Malnutrition (HP:0004395)2.69078104
41Fragile nails (HP:0001808)2.69075607
42Onycholysis (HP:0001806)2.65409036
43Follicular hyperkeratosis (HP:0007502)2.63750708
44Esophageal varix (HP:0002040)2.63655048
45Delayed CNS myelination (HP:0002188)2.63063239
46Hypercholesterolemia (HP:0003124)2.60729000
47Abnormality of fatty-acid metabolism (HP:0004359)2.59835940
48Steatorrhea (HP:0002570)2.57801128
49Cardiovascular calcification (HP:0011915)2.54524540
50Abnormality of the nasal septum (HP:0000419)2.54196991
51Abnormality of complement system (HP:0005339)2.54111237
52Hyperinsulinemic hypoglycemia (HP:0000825)2.53337515
53Spontaneous abortion (HP:0005268)2.51774311
54Gout (HP:0001997)2.47581247
55Conjugated hyperbilirubinemia (HP:0002908)2.47317392
56Vitreoretinal degeneration (HP:0000655)2.46105525
57Ileus (HP:0002595)2.46005306
58Dicarboxylic aciduria (HP:0003215)2.37659687
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37659687
60Symptomatic seizures (HP:0011145)2.37579544
61Nonimmune hydrops fetalis (HP:0001790)2.37336371
62Amyloidosis (HP:0011034)2.33380056
63Hepatocellular carcinoma (HP:0001402)2.30969311
64Abnormal hemoglobin (HP:0011902)2.29891750
65Enlarged penis (HP:0000040)2.28253426
66Hypotrichosis (HP:0001006)2.28114517
67Advanced eruption of teeth (HP:0006288)2.27932185
68Abdominal distention (HP:0003270)2.24400283
69Distal lower limb muscle weakness (HP:0009053)2.22652813
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22216671
71Polycythemia (HP:0001901)2.20611487
72Pigmentary retinal degeneration (HP:0001146)2.20537824
73Widely patent fontanelles and sutures (HP:0004492)2.15303060
74Protuberant abdomen (HP:0001538)2.14391695
75Sparse eyelashes (HP:0000653)2.14390102
76Plantar hyperkeratosis (HP:0007556)2.12494279
77Abnormality of proline metabolism (HP:0010907)2.12281407
78Hydroxyprolinuria (HP:0003080)2.12281407
79Lethargy (HP:0001254)2.11382189
80Woolly hair (HP:0002224)2.11296682
81Parakeratosis (HP:0001036)2.11002682
82Thick nail (HP:0001805)2.09955316
83Abnormality of purine metabolism (HP:0004352)2.09657142
84Rickets (HP:0002748)2.09532006
85Hyporeflexia of lower limbs (HP:0002600)2.07653377
86Menorrhagia (HP:0000132)2.06229722
87Facial shape deformation (HP:0011334)2.05606799
88Potter facies (HP:0002009)2.05606799
89Ventricular tachycardia (HP:0004756)2.03784463
90Epiphyseal dysplasia (HP:0002656)2.02558394
91Hyperbilirubinemia (HP:0002904)2.00991663
92Metabolic acidosis (HP:0001942)2.00547052
93Hypophosphatemic rickets (HP:0004912)2.00508228
94Abnormality of nucleobase metabolism (HP:0010932)1.98842374
95Myocardial infarction (HP:0001658)1.97451400
96Flat acetabular roof (HP:0003180)1.96990226
97Lip pit (HP:0100267)1.95950350
98Milia (HP:0001056)1.95062413
99Abnormality of the pancreatic islet cells (HP:0006476)1.94595701
100Abnormality of endocrine pancreas physiology (HP:0012093)1.94595701
101Elfin facies (HP:0004428)1.94571300
102Respiratory distress (HP:0002098)1.93474758
103Reduced subcutaneous adipose tissue (HP:0003758)1.93211147
104Alopecia of scalp (HP:0002293)1.92866138
105Abnormality of the ischium (HP:0003174)1.92460446
106Abnormality of serum amino acid levels (HP:0003112)1.92262154
107Abnormality of carpal bone ossification (HP:0006257)1.91451462
108Cerebral edema (HP:0002181)1.91023440
109Pili torti (HP:0003777)1.90691395
110Abnormality of glycolysis (HP:0004366)1.89669661
111Abnormal foot bone ossification (HP:0010675)1.88405686
112Cerebral hemorrhage (HP:0001342)1.86957911
113Abnormal hair laboratory examination (HP:0003328)1.86949350
114Hyperglycemia (HP:0003074)1.85450032
115Ketoacidosis (HP:0001993)1.85006239
116Spastic paraparesis (HP:0002313)1.84532030
117Increased serum pyruvate (HP:0003542)1.83440677
118Glomerulosclerosis (HP:0000096)1.80061527
119Bronchomalacia (HP:0002780)1.78945085
120Enlarged kidneys (HP:0000105)1.78426583
121Acanthosis nigricans (HP:0000956)1.78418117
122Hypoplastic ischia (HP:0003175)1.77487166
123Abnormality of pyrimidine metabolism (HP:0004353)1.77212837
124Cupped ribs (HP:0000887)1.77139479
125Delayed epiphyseal ossification (HP:0002663)1.76442966
126Vacuolated lymphocytes (HP:0001922)1.76247013
127Insulin-resistant diabetes mellitus (HP:0000831)1.76145210
128Abnormality of dental color (HP:0011073)1.75973470
129Congenital, generalized hypertrichosis (HP:0004540)1.74728177
130Abnormal gallbladder physiology (HP:0012438)1.74465167
131Cholecystitis (HP:0001082)1.74465167
132Glycosuria (HP:0003076)1.73647102
133Abnormality of urine glucose concentration (HP:0011016)1.73647102
134Increased purine levels (HP:0004368)1.73564747
135Hyperuricemia (HP:0002149)1.73564747
136Bifid scrotum (HP:0000048)1.73524447
137Alkalosis (HP:0001948)1.73094619
138Focal segmental glomerulosclerosis (HP:0000097)1.72786403
139Broad metatarsal (HP:0001783)1.71681287
140Pancreatitis (HP:0001733)1.71196995
141Proximal tubulopathy (HP:0000114)1.70131960
142Arterial tortuosity (HP:0005116)1.69662084
143Back pain (HP:0003418)1.67737939
144Irregular epiphyses (HP:0010582)1.67342592
145Generalized aminoaciduria (HP:0002909)1.67100688
146Purpura (HP:0000979)1.66067944
147Long foot (HP:0001833)1.65794681
148Abnormality of the gastric mucosa (HP:0004295)1.65772704
149Seborrheic dermatitis (HP:0001051)1.65661812
150Skin nodule (HP:0200036)1.65330521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.93275922
2KDR4.25837837
3ERN13.28090351
4BCKDK3.25041797
5EPHB22.51831719
6MAP3K32.43489136
7MST1R2.40700747
8TGFBR22.35540640
9FGFR42.35133831
10BRSK22.18259921
11EPHA22.05678536
12MAP3K122.00775167
13EPHB11.98428262
14GRK11.92809503
15MET1.90959236
16TGFBR11.89507953
17MYLK1.83964981
18STK38L1.78811796
19FER1.76000684
20BCR1.69020389
21LATS11.68009671
22STK241.59278158
23MAP2K61.49444108
24PRKG21.49417777
25PIK3CA1.40942409
26MAPK151.40888007
27MAP2K21.37839261
28STK391.36956886
29MST41.34985014
30SIK11.31365975
31NUAK11.27897030
32NEK91.24646447
33MUSK1.19751295
34NME11.18610218
35ERBB41.17992032
36MAP2K31.14345678
37PTK61.12525798
38WEE11.11617360
39MAP3K111.01925494
40OBSCN1.01504596
41WNK40.93832391
42EPHA30.93673544
43FGFR30.92064677
44TRPM70.91918857
45SIK30.90373345
46LMTK20.90142673
47PRKD10.88796587
48RIPK10.88611783
49STK380.88031548
50PTK20.87898293
51FRK0.87246393
52ICK0.83584782
53PRKCI0.82427750
54PAK40.82392981
55MAPKAPK30.81943998
56MAP2K10.80901892
57IRAK30.80803975
58AKT30.80042383
59OXSR10.77398800
60PTK2B0.77260256
61RPS6KB20.77214367
62LRRK20.76597285
63MAP3K20.76550867
64MAPK70.75305644
65PIK3CG0.73651066
66PDK20.72478067
67MAP3K70.71422822
68PKN20.70832231
69MAP3K140.70795363
70GSK3A0.69684798
71MAPK120.68020576
72NME20.65787072
73MAPK110.65131972
74FGFR10.64635337
75BRSK10.64038656
76LIMK10.63863152
77MAP3K10.62441479
78FGFR20.62269096
79STK30.62107946
80PBK0.61445776
81PINK10.61175113
82TAOK30.60843271
83DYRK1B0.60692595
84CAMK2G0.58716985
85NEK60.58473191
86CSNK1G10.58232403
87FLT30.57568080
88CSNK1A1L0.57037227
89INSRR0.56318366
90IKBKB0.56064995
91ILK0.55370975
92LATS20.53497641
93EIF2AK10.52753864
94PKN10.50256210
95CSNK1G20.49718567
96PRKAA20.49662331
97BMPR1B0.49127749
98CSNK1G30.48444928
99ERBB20.46966158
100TBK10.46798798
101PIM20.46472527
102CHUK0.46249762
103SMG10.45860902
104TRIB30.45533996
105MAPK40.44093301
106ABL20.43681999
107EEF2K0.42849801
108TESK10.41079097
109PRKCE0.39729200
110MTOR0.39459070
111DDR20.39402439
112PDGFRA0.37948049
113MAP4K20.37427302
114PRKAA10.36989696
115ROCK10.35248789
116CDK120.35099189
117RET0.33505011
118AKT20.33494380
119PDPK10.32683936
120TYK20.32058499
121EIF2AK30.31715806
122PRKD20.31207605
123IKBKE0.31020703
124ZAK0.30010099
125MAPKAPK50.29543263
126IGF1R0.27710131
127DAPK10.27556838
128PAK30.25036992
129CAMK2D0.24889097
130JAK20.24851980
131STK100.23392316
132NTRK10.22622921
133MAPKAPK20.20225826
134YES10.19436604
135SRC0.19392653

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.87489308
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99707713
3Complement and coagulation cascades_Homo sapiens_hsa046102.84598762
4Arginine biosynthesis_Homo sapiens_hsa002202.55190707
5Fatty acid degradation_Homo sapiens_hsa000712.52630293
6Nitrogen metabolism_Homo sapiens_hsa009102.52160559
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44927922
8Tryptophan metabolism_Homo sapiens_hsa003802.40734142
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.39949130
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34707145
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33595901
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30571066
13Histidine metabolism_Homo sapiens_hsa003402.27424318
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24486796
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.13131393
16Chemical carcinogenesis_Homo sapiens_hsa052042.11337390
17Sulfur metabolism_Homo sapiens_hsa009202.08378018
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02534268
19Fatty acid elongation_Homo sapiens_hsa000622.00637304
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96683311
21Retinol metabolism_Homo sapiens_hsa008301.87998126
22Peroxisome_Homo sapiens_hsa041461.84134458
23Propanoate metabolism_Homo sapiens_hsa006401.83160233
24Folate biosynthesis_Homo sapiens_hsa007901.82327626
25PPAR signaling pathway_Homo sapiens_hsa033201.81652701
26Butanoate metabolism_Homo sapiens_hsa006501.77945002
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.71579967
28Fatty acid metabolism_Homo sapiens_hsa012121.66873253
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65575736
30Phenylalanine metabolism_Homo sapiens_hsa003601.59660966
31Fat digestion and absorption_Homo sapiens_hsa049751.58737399
32Tyrosine metabolism_Homo sapiens_hsa003501.55436416
33beta-Alanine metabolism_Homo sapiens_hsa004101.55062273
34Caffeine metabolism_Homo sapiens_hsa002321.50562482
35Steroid biosynthesis_Homo sapiens_hsa001001.40938966
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.40299735
37Bile secretion_Homo sapiens_hsa049761.39920126
38Other glycan degradation_Homo sapiens_hsa005111.30986819
39Staphylococcus aureus infection_Homo sapiens_hsa051501.30661984
40Vitamin digestion and absorption_Homo sapiens_hsa049771.29276651
41Selenocompound metabolism_Homo sapiens_hsa004501.28180974
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.24501733
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.23337090
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22878034
45Arginine and proline metabolism_Homo sapiens_hsa003301.22662536
46Starch and sucrose metabolism_Homo sapiens_hsa005001.20349971
47Pyruvate metabolism_Homo sapiens_hsa006201.13836771
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.12003438
49ABC transporters_Homo sapiens_hsa020101.09791213
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07046490
51Glutathione metabolism_Homo sapiens_hsa004801.03844377
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01647089
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98461242
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93401459
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93372244
56Linoleic acid metabolism_Homo sapiens_hsa005910.89067050
57Carbon metabolism_Homo sapiens_hsa012000.87353117
58ECM-receptor interaction_Homo sapiens_hsa045120.81496627
59Prion diseases_Homo sapiens_hsa050200.80817640
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78623125
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77783402
62Vitamin B6 metabolism_Homo sapiens_hsa007500.77731252
63Biosynthesis of amino acids_Homo sapiens_hsa012300.75792446
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.74231266
65Circadian rhythm_Homo sapiens_hsa047100.70222734
66Protein digestion and absorption_Homo sapiens_hsa049740.66692632
67Glycerolipid metabolism_Homo sapiens_hsa005610.63583846
68Arachidonic acid metabolism_Homo sapiens_hsa005900.61211183
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61089308
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60894956
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59954077
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58533865
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57783095
74Metabolic pathways_Homo sapiens_hsa011000.54875284
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50349187
76AMPK signaling pathway_Homo sapiens_hsa041520.49289676
77N-Glycan biosynthesis_Homo sapiens_hsa005100.46351152
78Tight junction_Homo sapiens_hsa045300.46344677
79Adherens junction_Homo sapiens_hsa045200.45702101
80HIF-1 signaling pathway_Homo sapiens_hsa040660.44698640
81Ribosome_Homo sapiens_hsa030100.44443959
82Sphingolipid metabolism_Homo sapiens_hsa006000.43149463
83Glucagon signaling pathway_Homo sapiens_hsa049220.42973439
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41352346
85Thyroid hormone synthesis_Homo sapiens_hsa049180.41274117
86Mineral absorption_Homo sapiens_hsa049780.38929401
87Galactose metabolism_Homo sapiens_hsa000520.38822083
88Sulfur relay system_Homo sapiens_hsa041220.35338488
89Protein export_Homo sapiens_hsa030600.34050004
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.34026755
91Vibrio cholerae infection_Homo sapiens_hsa051100.33913473
92Ether lipid metabolism_Homo sapiens_hsa005650.33664827
93Pentose phosphate pathway_Homo sapiens_hsa000300.32896826
94Pertussis_Homo sapiens_hsa051330.32516425
95Lysine degradation_Homo sapiens_hsa003100.32397558
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31355617
97Oxidative phosphorylation_Homo sapiens_hsa001900.30500395
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28695509
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28597484
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26682051
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26297044
102Hepatitis C_Homo sapiens_hsa051600.25604196
103Bladder cancer_Homo sapiens_hsa052190.23330995
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22826550
105Insulin resistance_Homo sapiens_hsa049310.22570205
106TGF-beta signaling pathway_Homo sapiens_hsa043500.18926007
107Basal cell carcinoma_Homo sapiens_hsa052170.18875478
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.18515603
109Regulation of autophagy_Homo sapiens_hsa041400.17053249
110Focal adhesion_Homo sapiens_hsa045100.14225036
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.13477267
112Fructose and mannose metabolism_Homo sapiens_hsa000510.12770081
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12674570
114Ovarian steroidogenesis_Homo sapiens_hsa049130.12144644
115Parkinsons disease_Homo sapiens_hsa050120.12022464
116Fatty acid biosynthesis_Homo sapiens_hsa000610.09609472
117Hippo signaling pathway_Homo sapiens_hsa043900.09559773
118Amoebiasis_Homo sapiens_hsa051460.09312653
119Renin-angiotensin system_Homo sapiens_hsa046140.08909746

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