EFNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.99438969
2axon ensheathment in central nervous system (GO:0032291)6.99438969
3intestinal absorption (GO:0050892)5.08621262
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.87047556
5regulation of bile acid biosynthetic process (GO:0070857)4.53737227
6regulation of cholesterol homeostasis (GO:2000188)4.45611410
7very-low-density lipoprotein particle assembly (GO:0034379)4.24715518
8plasma lipoprotein particle assembly (GO:0034377)4.14842724
9lateral sprouting from an epithelium (GO:0060601)4.04721737
10neuron cell-cell adhesion (GO:0007158)4.04282595
11dendritic spine morphogenesis (GO:0060997)3.89190946
12myelination (GO:0042552)3.88936078
13axon ensheathment (GO:0008366)3.87834636
14ensheathment of neurons (GO:0007272)3.87834636
15chaperone-mediated protein transport (GO:0072321)3.78476371
16limb bud formation (GO:0060174)3.76227310
17cell migration in hindbrain (GO:0021535)3.66542875
18angiotensin maturation (GO:0002003)3.61947133
19protein-lipid complex assembly (GO:0065005)3.59614647
20neuron recognition (GO:0008038)3.53970135
21nucleobase catabolic process (GO:0046113)3.53854709
22proline metabolic process (GO:0006560)3.52768844
23presynaptic membrane assembly (GO:0097105)3.49693302
24intestinal cholesterol absorption (GO:0030299)3.47500895
25proline biosynthetic process (GO:0006561)3.39430437
26vitamin transmembrane transport (GO:0035461)3.38977508
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.36690916
28regulation of cholesterol biosynthetic process (GO:0045540)3.31578917
29lung-associated mesenchyme development (GO:0060484)3.27198959
30low-density lipoprotein particle remodeling (GO:0034374)3.24607987
31renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.24586075
32plasma lipoprotein particle remodeling (GO:0034369)3.24104517
33protein-lipid complex remodeling (GO:0034368)3.24104517
34macromolecular complex remodeling (GO:0034367)3.24104517
35presynaptic membrane organization (GO:0097090)3.23080425
36axonal fasciculation (GO:0007413)3.22366569
37myelination in peripheral nervous system (GO:0022011)3.19540320
38peripheral nervous system axon ensheathment (GO:0032292)3.19540320
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18911884
40cerebral cortex radially oriented cell migration (GO:0021799)3.18683558
41cell-cell junction maintenance (GO:0045217)3.18582210
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17574999
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16986003
44lung epithelium development (GO:0060428)3.16223195
45diacylglycerol metabolic process (GO:0046339)3.14976318
46urea cycle (GO:0000050)3.14089873
47glucose 6-phosphate metabolic process (GO:0051156)3.12436913
48plasma lipoprotein particle organization (GO:0071827)3.10761234
49establishment of mitochondrion localization (GO:0051654)3.10326255
50regulation of cholesterol esterification (GO:0010872)3.06986203
51negative regulation of axon extension (GO:0030517)3.06642263
52negative regulation of cholesterol transport (GO:0032375)3.05098788
53negative regulation of sterol transport (GO:0032372)3.05098788
54regulation of collateral sprouting (GO:0048670)3.04876458
55substantia nigra development (GO:0021762)3.02091427
56lens fiber cell development (GO:0070307)3.00577211
57cell junction maintenance (GO:0034331)2.99684666
58convergent extension (GO:0060026)2.97788530
59urea metabolic process (GO:0019627)2.97470140
60embryonic retina morphogenesis in camera-type eye (GO:0060059)2.97244469
61central nervous system projection neuron axonogenesis (GO:0021952)2.95641000
62protein neddylation (GO:0045116)2.95570217
63regulation of cholesterol metabolic process (GO:0090181)2.94507276
64NADH metabolic process (GO:0006734)2.93923167
65head development (GO:0060322)2.93803301
66regulation of guanylate cyclase activity (GO:0031282)2.93215542
67apical protein localization (GO:0045176)2.92555284
68lipoprotein transport (GO:0042953)2.91140016
69cranial nerve morphogenesis (GO:0021602)2.90518828
70endocrine process (GO:0050886)2.89239739
71regulation of systemic arterial blood pressure by hormone (GO:0001990)2.89239739
72regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.89239739
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.88688845
74negative regulation of astrocyte differentiation (GO:0048712)2.88533010
75protein-lipid complex subunit organization (GO:0071825)2.86944798
76cholesterol efflux (GO:0033344)2.86553039
77transmission of nerve impulse (GO:0019226)2.85973681
78negative regulation of fibrinolysis (GO:0051918)2.84630737
79glutamine family amino acid biosynthetic process (GO:0009084)2.84049138
80protein retention in ER lumen (GO:0006621)2.83824409
81cholesterol biosynthetic process (GO:0006695)2.83350340
82midgut development (GO:0007494)2.81640084
83negative regulation of glial cell differentiation (GO:0045686)2.81626336
84negative regulation of axonogenesis (GO:0050771)2.81281384
85renal system process involved in regulation of blood volume (GO:0001977)2.80941985
86positive regulation of synapse assembly (GO:0051965)2.80654046
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.79234010
88regulation of systemic arterial blood pressure (GO:0003073)2.79089087
89G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.78540870
90regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.77664843
91oligodendrocyte differentiation (GO:0048709)2.76805495
92epithelial cell fate commitment (GO:0072148)2.76636457
93pyrimidine nucleobase catabolic process (GO:0006208)2.75849045
94high-density lipoprotein particle remodeling (GO:0034375)2.75526134
95forebrain neuron development (GO:0021884)2.73547162
96positive regulation of pseudopodium assembly (GO:0031274)2.68923017
97negative regulation of microtubule polymerization (GO:0031115)2.68402544
98protein carboxylation (GO:0018214)2.67719441
99peptidyl-glutamic acid carboxylation (GO:0017187)2.67719441
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65962085
101regulation of NFAT protein import into nucleus (GO:0051532)2.65062457
102DNA damage response, detection of DNA damage (GO:0042769)2.65027179
103negative regulation of neurotransmitter secretion (GO:0046929)2.64879314
104long-chain fatty acid biosynthetic process (GO:0042759)2.64387416
105epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.63876839
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63782258
107cellular glucuronidation (GO:0052695)2.63748173
108cellular response to prostaglandin stimulus (GO:0071379)2.63463939
109COPI coating of Golgi vesicle (GO:0048205)2.62457125
110Golgi transport vesicle coating (GO:0048200)2.62457125
111establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.62409463
112cell fate commitment involved in formation of primary germ layer (GO:0060795)2.62051786
113dopaminergic neuron differentiation (GO:0071542)2.60922760
114negative regulation of catenin import into nucleus (GO:0035414)2.60897501
115negative regulation of axon guidance (GO:1902668)2.60246774
116regulation of somitogenesis (GO:0014807)2.60232917
117embryonic skeletal joint morphogenesis (GO:0060272)2.60119289
118nitrogen cycle metabolic process (GO:0071941)2.60113225
119RNA localization (GO:0006403)2.59925637
120negative regulation of smoothened signaling pathway (GO:0045879)2.59743244
121fructose metabolic process (GO:0006000)2.59272322
122sulfate transmembrane transport (GO:1902358)2.58761530
123histone H2B ubiquitination (GO:0033523)2.58635483
124fat-soluble vitamin biosynthetic process (GO:0042362)2.58145863
125layer formation in cerebral cortex (GO:0021819)2.58122300
126cranial nerve development (GO:0021545)2.58059459
127negative regulation of gliogenesis (GO:0014014)2.57799915
128fatty acid elongation (GO:0030497)2.57516549
129flavonoid metabolic process (GO:0009812)2.56958346
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.55653026
131positive regulation of oligodendrocyte differentiation (GO:0048714)2.54962289
132drinking behavior (GO:0042756)2.54113271
133phospholipid efflux (GO:0033700)2.52666641
134reverse cholesterol transport (GO:0043691)2.52281985
135asymmetric protein localization (GO:0008105)2.51978823
136regulation of respiratory system process (GO:0044065)2.51558963
137retinal ganglion cell axon guidance (GO:0031290)2.51148715
138gap junction assembly (GO:0016264)2.50348044
139epoxygenase P450 pathway (GO:0019373)2.50262877
140isoprenoid biosynthetic process (GO:0008299)2.49667158
141desmosome organization (GO:0002934)2.48749701
142collecting duct development (GO:0072044)2.48417228
143skeletal muscle organ development (GO:0060538)2.47383901
144cell proliferation in forebrain (GO:0021846)2.46854812
145negative regulation of neurotransmitter transport (GO:0051589)2.46048842
146central nervous system neuron axonogenesis (GO:0021955)2.45933904
147polarized epithelial cell differentiation (GO:0030859)2.45479782
148uronic acid metabolic process (GO:0006063)2.45197363
149glucuronate metabolic process (GO:0019585)2.45197363
150positive regulation of triglyceride lipase activity (GO:0061365)2.44525972
151positive regulation of lipoprotein lipase activity (GO:0051006)2.44525972
152establishment of protein localization to mitochondrial membrane (GO:0090151)2.43709959
153spinal cord motor neuron differentiation (GO:0021522)2.43007870
154positive regulation of meiosis (GO:0045836)2.41543034
155sterol biosynthetic process (GO:0016126)2.40882442
156dendrite morphogenesis (GO:0048813)2.40094618
157keratinocyte development (GO:0003334)2.39950197
158lipoprotein metabolic process (GO:0042157)2.39922589
159dendritic spine organization (GO:0097061)2.39499523
160positive regulation of lipid catabolic process (GO:0050996)2.39454816
161neural nucleus development (GO:0048857)2.38558292
162maintenance of gastrointestinal epithelium (GO:0030277)2.38404476
163hippocampus development (GO:0021766)2.38035687
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38019631
165regulation of fibrinolysis (GO:0051917)2.37858595
166ectodermal placode formation (GO:0060788)2.37514835
167vocalization behavior (GO:0071625)2.37439414
168short-term memory (GO:0007614)2.37340121
169notochord development (GO:0030903)2.36304407
170regulation of oligodendrocyte differentiation (GO:0048713)2.34304087
171astrocyte development (GO:0014002)2.33804165
172enteric nervous system development (GO:0048484)2.33291537
173postsynaptic membrane organization (GO:0001941)2.32387712
174somite development (GO:0061053)2.32250740
175mesenchymal to epithelial transition (GO:0060231)2.31023162
176establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29783745
177mitochondrion transport along microtubule (GO:0047497)2.29783745
178positive regulation of meiotic cell cycle (GO:0051446)2.29491854
179negative regulation of protein localization to cell surface (GO:2000009)2.28364865
180regulation of glial cell differentiation (GO:0045685)2.28062880
181paraxial mesoderm development (GO:0048339)2.26864879
182semaphorin-plexin signaling pathway (GO:0071526)2.24384205
183endocardial cushion morphogenesis (GO:0003203)2.23522077
184thalamus development (GO:0021794)2.21899214
185positive regulation of gastrulation (GO:2000543)2.21645946
186mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.21063156
187hindlimb morphogenesis (GO:0035137)2.18754059
188dendrite development (GO:0016358)2.18673354
189mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.18018212
190regulation of astrocyte differentiation (GO:0048710)2.17643866
191negative regulation of JAK-STAT cascade (GO:0046426)2.17157830
192regulation of respiratory gaseous exchange (GO:0043576)2.16979882
193* ephrin receptor signaling pathway (GO:0048013)2.16146648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12016133
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33891258
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.31910698
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.17945183
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.15816298
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82094433
7ZNF263_19887448_ChIP-Seq_K562_Human2.54290960
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53027995
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53027995
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.50004055
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.48858021
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48203903
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42816316
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.40538179
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37787148
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29733183
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27184377
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26317824
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18037792
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16381453
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.12369818
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09767240
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08927847
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07812588
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05354134
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04733783
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03800556
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99209265
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97440561
30LXR_22292898_ChIP-Seq_THP-1_Human1.95882930
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90613597
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88473334
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86474796
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82181332
35RNF2_27304074_Chip-Seq_NSC_Mouse1.80949362
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.80482145
37* RING1B_27294783_Chip-Seq_NPCs_Mouse1.72024784
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.69705564
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68586765
40CLOCK_20551151_ChIP-Seq_293T_Human1.66757172
41CTCF_27219007_Chip-Seq_Bcells_Human1.66441135
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65991949
43* KDM2B_26808549_Chip-Seq_K562_Human1.65671191
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.63540618
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63504008
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62687740
47RACK7_27058665_Chip-Seq_MCF-7_Human1.60318378
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58911485
49FUS_26573619_Chip-Seq_HEK293_Human1.57762841
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55967375
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54669805
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.53802859
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.52903574
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52622018
55* REST_21632747_ChIP-Seq_MESCs_Mouse1.50973434
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50889065
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49259354
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49060459
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49060459
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49060459
61VDR_22108803_ChIP-Seq_LS180_Human1.46566379
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46281131
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.44958110
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42604102
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42497917
66GBX2_23144817_ChIP-Seq_PC3_Human1.40875412
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.40473090
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39370786
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38929219
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.38775884
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.38474898
72* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38470238
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37702972
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.36993229
75CREB1_26743006_Chip-Seq_LNCaP_Human1.36988926
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34945377
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32314878
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31951178
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30690032
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29805078
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29767227
82GATA6_25053715_ChIP-Seq_YYC3_Human1.28685582
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24642772
84* REST_18959480_ChIP-ChIP_MESCs_Mouse1.23748270
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.23701059
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.22679148
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22554970
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22002681
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21742511
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21295542
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.20675487
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20563748
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19242473
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18455400
95ZNF274_21170338_ChIP-Seq_K562_Hela1.17670216
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16725588
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16440528
98AR_21572438_ChIP-Seq_LNCaP_Human1.16378286
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15884186
100GATA4_25053715_ChIP-Seq_YYC3_Human1.15193048
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14308683
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13078612
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12500573
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11568882
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11452625
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11388851
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10499707
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10487747
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10378298
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.10073601
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.09485138
112* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09274071
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08332627
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08205631
115P68_20966046_ChIP-Seq_HELA_Human1.08172345
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06820343
117AR_21909140_ChIP-Seq_LNCAP_Human1.06666624
118GATA1_26923725_Chip-Seq_HPCs_Mouse1.06505978
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06211001
120* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06088475
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05761175
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.05365410
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05227959
124ETS1_20019798_ChIP-Seq_JURKAT_Human1.04741044
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04223659
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03968946
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.03374455
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.03322920
129KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02850147
130POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.02745090
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02340391
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.01288211
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01141843
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00380107
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00220070
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99636831
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97147797
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96587999
139GABP_17652178_ChIP-ChIP_JURKAT_Human0.95838171
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95720043
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.95430440
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95153074
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94862325
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94410206
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94203748
146SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94100692
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90365872
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.88752466
149SOX9_26525672_Chip-Seq_HEART_Mouse0.88610822
150MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87327153
151DROSHA_22980978_ChIP-Seq_HELA_Human0.86934999
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85587231
153TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84332860
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83298512
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82609480
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82342019
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82072626
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81470139
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80274361
160TAF15_26573619_Chip-Seq_HEK293_Human0.80016710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.07533940
2MP0003880_abnormal_central_pattern4.56395990
3MP0002139_abnormal_hepatobiliary_system4.13625996
4MP0010234_abnormal_vibrissa_follicle3.68524131
5MP0000566_synostosis3.15238765
6MP0005365_abnormal_bile_salt3.05107373
7MP0005423_abnormal_somatic_nervous3.03961500
8MP0010030_abnormal_orbit_morphology2.96373829
9MP0004264_abnormal_extraembryonic_tissu2.84284591
10MP0000778_abnormal_nervous_system2.72929981
11MP0001666_abnormal_nutrient_absorption2.64601405
12MP0005085_abnormal_gallbladder_physiolo2.41224189
13MP0003938_abnormal_ear_development2.32859793
14MP0002102_abnormal_ear_morphology2.25425056
15MP0003136_yellow_coat_color2.21962994
16MP0000049_abnormal_middle_ear2.13822171
17MP0004270_analgesia2.13553363
18MP0001529_abnormal_vocalization2.03409835
19MP0005257_abnormal_intraocular_pressure1.97483840
20MP0003567_abnormal_fetal_cardiomyocyte1.86944459
21MP0003937_abnormal_limbs/digits/tail_de1.82946092
22MP0000537_abnormal_urethra_morphology1.80798654
23MP0001485_abnormal_pinna_reflex1.80072017
24MP0002938_white_spotting1.78374016
25MP0009250_abnormal_appendicular_skeleto1.77797795
26MP0002089_abnormal_postnatal_growth/wei1.69856352
27MP0010329_abnormal_lipoprotein_level1.67756422
28MP0002653_abnormal_ependyma_morphology1.63467838
29MP0001346_abnormal_lacrimal_gland1.61632740
30MP0004742_abnormal_vestibular_system1.61169768
31MP0002249_abnormal_larynx_morphology1.61001788
32MP0003755_abnormal_palate_morphology1.60840496
33MP0000462_abnormal_digestive_system1.60650172
34MP0003385_abnormal_body_wall1.60539227
35MP0006072_abnormal_retinal_apoptosis1.56934747
36MP0008789_abnormal_olfactory_epithelium1.55704124
37MP0002751_abnormal_autonomic_nervous1.53478103
38* MP0003861_abnormal_nervous_system1.52250808
39MP0003119_abnormal_digestive_system1.52110439
40* MP0002184_abnormal_innervation1.51401192
41MP0001486_abnormal_startle_reflex1.49307523
42MP0004859_abnormal_synaptic_plasticity1.48921476
43MP0005076_abnormal_cell_differentiation1.46024072
44MP0003868_abnormal_feces_composition1.45872202
45MP0003122_maternal_imprinting1.41265171
46MP0008932_abnormal_embryonic_tissue1.39761552
47MP0002697_abnormal_eye_size1.39193374
48MP0005171_absent_coat_pigmentation1.38051454
49MP0000678_abnormal_parathyroid_gland1.37838018
50MP0003315_abnormal_perineum_morphology1.37551577
51MP0002098_abnormal_vibrissa_morphology1.36740501
52* MP0002882_abnormal_neuron_morphology1.36613854
53MP0001664_abnormal_digestion1.36435605
54MP0000955_abnormal_spinal_cord1.35475879
55MP0003635_abnormal_synaptic_transmissio1.34741286
56MP0004885_abnormal_endolymph1.32127665
57MP0000026_abnormal_inner_ear1.32006712
58MP0000477_abnormal_intestine_morphology1.31934998
59MP0003890_abnormal_embryonic-extraembry1.31784968
60MP0006276_abnormal_autonomic_nervous1.31300824
61* MP0002752_abnormal_somatic_nervous1.31162456
62MP0009379_abnormal_foot_pigmentation1.30973644
63MP0005623_abnormal_meninges_morphology1.30387163
64MP0003115_abnormal_respiratory_system1.30384231
65MP0000762_abnormal_tongue_morphology1.27536024
66* MP0002152_abnormal_brain_morphology1.26622389
67MP0004134_abnormal_chest_morphology1.26328137
68MP0000920_abnormal_myelination1.25782638
69MP0004133_heterotaxia1.25757056
70MP0002734_abnormal_mechanical_nocicepti1.25288060
71MP0004019_abnormal_vitamin_homeostasis1.24922610
72MP0000428_abnormal_craniofacial_morphol1.24141639
73MP0003123_paternal_imprinting1.23928556
74MP0002909_abnormal_adrenal_gland1.23147346
75MP0000631_abnormal_neuroendocrine_gland1.22588176
76MP0009053_abnormal_anal_canal1.22293362
77MP0003634_abnormal_glial_cell1.20982865
78MP0006292_abnormal_olfactory_placode1.19642277
79MP0002822_catalepsy1.19046610
80MP0003121_genomic_imprinting1.18968526
81MP0005499_abnormal_olfactory_system1.18266843
82MP0005394_taste/olfaction_phenotype1.18266843
83MP0001905_abnormal_dopamine_level1.17461399
84MP0002272_abnormal_nervous_system1.16805941
85MP0003942_abnormal_urinary_system1.16401527
86MP0002116_abnormal_craniofacial_bone1.15452179
87MP0001440_abnormal_grooming_behavior1.15099945
88MP0002233_abnormal_nose_morphology1.12238651
89MP0001188_hyperpigmentation1.11970062
90MP0009780_abnormal_chondrocyte_physiolo1.11887037
91MP0002092_abnormal_eye_morphology1.11851171
92MP0002063_abnormal_learning/memory/cond1.11445770
93MP0001293_anophthalmia1.10734311
94MP0002064_seizures1.09661773
95MP0001286_abnormal_eye_development1.08123396
96MP0000534_abnormal_ureter_morphology1.07547726
97MP0000647_abnormal_sebaceous_gland1.06677437
98MP0005248_abnormal_Harderian_gland1.05375200
99MP0001299_abnormal_eye_distance/1.05173778
100MP0003693_abnormal_embryo_hatching1.04733683
101MP0003283_abnormal_digestive_organ1.03968736
102MP0003935_abnormal_craniofacial_develop1.03014985
103MP0002572_abnormal_emotion/affect_behav1.02646573
104MP0005409_darkened_coat_color1.01358700
105MP0002111_abnormal_tail_morphology1.00835493
106MP0004142_abnormal_muscle_tone1.00314861
107MP0002282_abnormal_trachea_morphology0.98725685
108MP0002932_abnormal_joint_morphology0.98045409
109MP0009672_abnormal_birth_weight0.97863832
110MP0001340_abnormal_eyelid_morphology0.95484109
111MP0001963_abnormal_hearing_physiology0.93744371
112MP0005195_abnormal_posterior_eye0.92456218
113MP0002067_abnormal_sensory_capabilities0.92432947
114MP0001984_abnormal_olfaction0.91486263
115MP0002081_perinatal_lethality0.90974957
116MP0000490_abnormal_crypts_of0.90168253
117MP0002733_abnormal_thermal_nociception0.89726825
118MP0002114_abnormal_axial_skeleton0.89673940
119MP0004858_abnormal_nervous_system0.89168112
120MP0003329_amyloid_beta_deposits0.88918496
121MP0003718_maternal_effect0.88151125
122MP0002066_abnormal_motor_capabilities/c0.87921886
123MP0002177_abnormal_outer_ear0.87475628
124MP0000383_abnormal_hair_follicle0.87026123
125MP0004782_abnormal_surfactant_physiolog0.86326287
126MP0002163_abnormal_gland_morphology0.86004098
127MP0002085_abnormal_embryonic_tissue0.85919932
128MP0000432_abnormal_head_morphology0.84867925
129MP0002557_abnormal_social/conspecific_i0.84472584
130MP0003183_abnormal_peptide_metabolism0.83269689
131MP0004272_abnormal_basement_membrane0.82800584
132MP0009384_cardiac_valve_regurgitation0.79355246
133MP0001730_embryonic_growth_arrest0.77587458
134MP0001849_ear_inflammation0.75146700
135MP0000467_abnormal_esophagus_morphology0.73628773
136MP0005501_abnormal_skin_physiology0.72343228
137MP0004197_abnormal_fetal_growth/weight/0.71865018
138MP0005451_abnormal_body_composition0.69759560
139MP0002084_abnormal_developmental_patter0.67850384
140MP0005187_abnormal_penis_morphology0.67048434
141MP0010352_gastrointestinal_tract_polyps0.65292038
142MP0002876_abnormal_thyroid_physiology0.63823953
143MP0002638_abnormal_pupillary_reflex0.60555663
144MP0002069_abnormal_eating/drinking_beha0.60326075
145MP0000609_abnormal_liver_physiology0.60065620
146MP0004147_increased_porphyrin_level0.60039205
147MP0005670_abnormal_white_adipose0.59702299

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.58610713
2Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91062924
3Hemorrhage of the eye (HP:0011885)3.70505604
4Alacrima (HP:0000522)3.48301329
5Concave nail (HP:0001598)3.46877076
6Hypobetalipoproteinemia (HP:0003563)3.40572608
7Flat acetabular roof (HP:0003180)3.40435392
8Coronal craniosynostosis (HP:0004440)3.21164115
9Neurofibrillary tangles (HP:0002185)3.17796490
10Decreased lacrimation (HP:0000633)3.07084341
11Abnormal tarsal ossification (HP:0008369)3.04607875
12Megalencephaly (HP:0001355)2.94300821
13Partial duplication of the phalanx of hand (HP:0009999)2.89573479
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.89270845
15Aplasia involving bones of the upper limbs (HP:0009823)2.87692072
16Aplasia of the phalanges of the hand (HP:0009802)2.87692072
17Aplasia involving bones of the extremities (HP:0009825)2.87692072
18Hepatoblastoma (HP:0002884)2.85765221
19Vitreoretinal degeneration (HP:0000655)2.83706445
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81773826
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.81773826
22Xanthomatosis (HP:0000991)2.80074462
23Broad palm (HP:0001169)2.76274516
24Vaginal fistula (HP:0004320)2.76155776
25Parakeratosis (HP:0001036)2.73262099
26Neonatal short-limb short stature (HP:0008921)2.72765321
27Partial duplication of thumb phalanx (HP:0009944)2.67633612
28Cerebral inclusion bodies (HP:0100314)2.64293542
29Abnormality of proline metabolism (HP:0010907)2.64210806
30Hydroxyprolinuria (HP:0003080)2.64210806
31Hypoplastic pelvis (HP:0008839)2.60116680
32Cerebral hypomyelination (HP:0006808)2.57765692
33Widely patent fontanelles and sutures (HP:0004492)2.50268368
34Abnormality of carpal bone ossification (HP:0006257)2.50143371
35Hypercholesterolemia (HP:0003124)2.48267763
36Wide cranial sutures (HP:0010537)2.43696105
37Bifid scrotum (HP:0000048)2.43138376
38Prolonged partial thromboplastin time (HP:0003645)2.42403648
39Delayed epiphyseal ossification (HP:0002663)2.38968521
40Thickened helices (HP:0000391)2.38324944
41Abnormality of the corticospinal tract (HP:0002492)2.35806452
42High anterior hairline (HP:0009890)2.32215379
43Abnormality of the phalanges of the hallux (HP:0010057)2.31284597
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30662343
45Asymmetry of the thorax (HP:0001555)2.29190477
46Abnormality of the intervertebral disk (HP:0005108)2.27916038
47Supranuclear gaze palsy (HP:0000605)2.27786197
48Sensory axonal neuropathy (HP:0003390)2.26697853
49Abnormality of the labia minora (HP:0012880)2.26347795
50Irregular epiphyses (HP:0010582)2.24992220
51Anteriorly placed anus (HP:0001545)2.23396416
52Aplasia involving forearm bones (HP:0009822)2.21746290
53Absent forearm bone (HP:0003953)2.21746290
54Absent radius (HP:0003974)2.20990533
55Myelomeningocele (HP:0002475)2.14330164
56Cupped ear (HP:0000378)2.13986936
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.12889957
58Abnormal ossification of hand bones (HP:0005921)2.11614815
59Hemiparesis (HP:0001269)2.09342722
60Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.08236558
61Abnormality of the middle phalanges of the toes (HP:0010183)2.07633520
62Late onset (HP:0003584)2.07629752
63Hyperglycinuria (HP:0003108)2.07624389
64Intrahepatic cholestasis (HP:0001406)2.07593614
65Broad alveolar ridges (HP:0000187)2.06683768
66Complement deficiency (HP:0004431)2.06245450
67Hyperactive renin-angiotensin system (HP:0000841)2.04937398
68Exotropia (HP:0000577)2.04692313
69Confusion (HP:0001289)2.04361216
70Glomerulonephritis (HP:0000099)2.03625741
71Abnormality of glycine metabolism (HP:0010895)2.02121805
72Abnormality of serine family amino acid metabolism (HP:0010894)2.02121805
73Ileus (HP:0002595)2.01275409
74Abnormality of complement system (HP:0005339)2.00934437
75Short 4th metacarpal (HP:0010044)1.99566027
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99566027
77Renal duplication (HP:0000075)1.99170869
78Bronchomalacia (HP:0002780)1.98652438
79Mixed hearing impairment (HP:0000410)1.98510378
80Split foot (HP:0001839)1.96876484
81Gout (HP:0001997)1.95717870
82Hyperacusis (HP:0010780)1.95690576
83Fat malabsorption (HP:0002630)1.94724987
84Hypolipoproteinemia (HP:0010981)1.94183949
85Neonatal death (HP:0003811)1.92431162
86Turricephaly (HP:0000262)1.91698388
87Trigonocephaly (HP:0000243)1.90526975
88Abnormal foot bone ossification (HP:0010675)1.89545322
89Ulnar bowing (HP:0003031)1.88673465
90Abdominal distention (HP:0003270)1.88278685
91Abnormal hand bone ossification (HP:0010660)1.88062630
92Preaxial foot polydactyly (HP:0001841)1.87599716
93Facial hemangioma (HP:0000329)1.87502599
94Esophageal atresia (HP:0002032)1.87467061
95Partial agenesis of the corpus callosum (HP:0001338)1.86771765
96Focal segmental glomerulosclerosis (HP:0000097)1.85838172
97Nasolacrimal duct obstruction (HP:0000579)1.85657470
98Rectal prolapse (HP:0002035)1.85499722
99Systemic lupus erythematosus (HP:0002725)1.85320392
100Abnormality of the nasolacrimal system (HP:0000614)1.84669134
101Hypoplastic left heart (HP:0004383)1.84349888
102Proximal tubulopathy (HP:0000114)1.83966108
103Progressive sensorineural hearing impairment (HP:0000408)1.83499906
104Cortical dysplasia (HP:0002539)1.83462229
105Retinal dysplasia (HP:0007973)1.83289527
106Abnormality of the septum pellucidum (HP:0007375)1.83051591
107Absent septum pellucidum (HP:0001331)1.82309821
108Abnormally folded helix (HP:0008544)1.82042969
109Synostosis involving the elbow (HP:0003938)1.81671423
110Humeroradial synostosis (HP:0003041)1.81671423
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81642723
112Absent epiphyses (HP:0010577)1.81642723
113Conjugated hyperbilirubinemia (HP:0002908)1.81494541
114Abnormality of the aortic arch (HP:0012303)1.81177347
115Joint hemorrhage (HP:0005261)1.80372483
116Overfolded helix (HP:0000396)1.80341443
117Double outlet right ventricle (HP:0001719)1.80266439
118Congenital malformation of the right heart (HP:0011723)1.80266439
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80059852
120Duplication of thumb phalanx (HP:0009942)1.78737334
121Atonic seizures (HP:0010819)1.78429082
122Abnormality of the 4th metacarpal (HP:0010012)1.77569846
123Epidermoid cyst (HP:0200040)1.77551386
124Abnormal sex determination (HP:0012244)1.77540452
125Sex reversal (HP:0012245)1.77540452
126Pterygium (HP:0001059)1.77006864
127Bowel incontinence (HP:0002607)1.76910524
128Flattened epiphyses (HP:0003071)1.76683092
129Septate vagina (HP:0001153)1.76607310
130Peripheral hypomyelination (HP:0007182)1.76495183
131Renovascular hypertension (HP:0100817)1.76352888
132Abnormality of the lacrimal duct (HP:0011481)1.76260485
133Midface retrusion (HP:0011800)1.76216896
134Growth hormone excess (HP:0000845)1.76132149
135Anophthalmia (HP:0000528)1.75596664
136Midline defect of the nose (HP:0004122)1.75116795
137Abnormality of the vitreous humor (HP:0004327)1.74089037
138Ectopic anus (HP:0004397)1.73964354
139Abnormal umbilical cord blood vessels (HP:0011403)1.73866425
140Single umbilical artery (HP:0001195)1.73866425
141Abnormality of the fetal cardiovascular system (HP:0010948)1.73866425
142Adrenal hypoplasia (HP:0000835)1.73781052
143Right ventricular cardiomyopathy (HP:0011663)1.72026144
144Aplasia/Hypoplasia of the patella (HP:0006498)1.71879550
145Chin dimple (HP:0010751)1.71645692
146Bifid tongue (HP:0010297)1.70931207
147Synostosis of carpal bones (HP:0005048)1.70505917
148Acanthocytosis (HP:0001927)1.68968057
149Proximal placement of thumb (HP:0009623)1.67929175
150Anal stenosis (HP:0002025)1.67842179
151Atelectasis (HP:0100750)1.67658978
152Thin bony cortex (HP:0002753)1.67595980
153Thin ribs (HP:0000883)1.66463978
154Rectovaginal fistula (HP:0000143)1.66410488
155Rectal fistula (HP:0100590)1.66410488
156Hyperglycinemia (HP:0002154)1.66033135
157Increased nuchal translucency (HP:0010880)1.65601980
158Intestinal fistula (HP:0100819)1.64344588
159Abnormal large intestine physiology (HP:0012700)1.64189753
160Limited elbow extension (HP:0001377)1.62813481
161Vertebral clefting (HP:0008428)1.62660922
162Abnormality of the gastric mucosa (HP:0004295)1.62485263
163Morphological abnormality of the inner ear (HP:0011390)1.62394819
164Tracheomalacia (HP:0002779)1.61454049
165Recurrent corneal erosions (HP:0000495)1.60840634
166Abnormality of the calcaneus (HP:0008364)1.60552327
167Truncus arteriosus (HP:0001660)1.60463450
168Morphological abnormality of the middle ear (HP:0008609)1.60259935
169Large earlobe (HP:0009748)1.60022347
170Insidious onset (HP:0003587)1.59695708
171Termporal pattern (HP:0011008)1.59695708
172Akinesia (HP:0002304)1.59669437
173Deviation of the thumb (HP:0009603)1.59515999
174Limb dystonia (HP:0002451)1.59447139
175Carpal synostosis (HP:0009702)1.59089918
176Glomerulosclerosis (HP:0000096)1.58914542
177Hemivertebrae (HP:0002937)1.58547670
178Abnormality of the parietal bone (HP:0002696)1.58314699
179Septo-optic dysplasia (HP:0100842)1.57761859
180Cutaneous finger syndactyly (HP:0010554)1.57590549
181Hamartoma (HP:0010566)1.56993172
182Excessive salivation (HP:0003781)1.56755243
183Drooling (HP:0002307)1.56755243
184Patellar aplasia (HP:0006443)1.56037347
185Abnormality of the phalanges of the 2nd finger (HP:0009541)1.56009745
186Aplasia/Hypoplasia of the clavicles (HP:0006710)1.55294276
187Supernumerary spleens (HP:0009799)1.54265412
188Restlessness (HP:0000711)1.53629308
189Spastic gait (HP:0002064)1.53425800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.68342945
2MARK13.81407767
3FGFR43.56104773
4STK393.01366104
5BUB12.93054847
6MST1R2.84991130
7RIPK12.83710889
8PNCK2.71357727
9SIK12.60174908
10LMTK22.56555580
11DYRK22.56333685
12TLK12.54505250
13CDK122.47406460
14ICK2.35359839
15UHMK12.34385101
16EPHA32.24854246
17BCR2.14192831
18EEF2K2.08793090
19CASK2.00188438
20MAPK131.98459210
21OXSR11.91263258
22TNIK1.87223974
23PKN11.85703665
24EPHA41.74422966
25TRIB31.69420334
26WNK41.67692357
27PHKG11.60410972
28PHKG21.60410972
29TESK21.59999974
30MKNK11.59847397
31CSNK1G31.56226411
32BRD41.53058573
33MKNK21.48207940
34TYRO31.47339240
35NTRK21.44298310
36EPHB11.42315557
37MAPK151.41173737
38EPHB21.38869057
39PTK61.37937819
40CDK191.34840361
41LIMK11.33988891
42CSNK1A1L1.32740455
43MAP3K91.32599965
44LATS21.27702838
45PAK31.26335654
46PIK3CA1.26025618
47SMG11.25498683
48SRPK11.24666660
49IRAK21.24252199
50DYRK31.23183245
51CSNK1G11.22543563
52PDGFRA1.19929645
53CSNK1G21.18030764
54FGFR31.17444501
55NTRK31.16437077
56PAK61.15191582
57PBK1.14800143
58CDK141.09548291
59PRKD31.06348577
60PRKG21.05890020
61STK161.05543546
62KSR21.04568732
63ROCK21.03259960
64IRAK31.01997823
65CAMK2B1.00136545
66ERBB20.99127010
67PRKD20.98619050
68CDK150.98326123
69FGFR20.96524021
70SIK20.96230634
71CDK180.94391750
72DDR20.93860258
73BMPR1B0.93788490
74RPS6KA40.91464441
75CDK11A0.90823616
76FGR0.88249206
77KSR10.88072154
78PRPF4B0.87048974
79PKN20.86620044
80DYRK1A0.83523126
81NEK20.79738099
82NTRK10.79342973
83PAK40.79192501
84MET0.76534029
85MINK10.75266428
86IRAK10.73046864
87ILK0.72363167
88RET0.71680781
89AURKA0.71123899
90BRAF0.69151672
91CDK70.68627599
92NME10.68327938
93CDK50.67852099
94ERN10.67241551
95MTOR0.66451282
96WNK30.65747843
97MAP2K40.65472478
98CHEK20.64626320
99WNK10.64060097
100NEK60.63770362
101CAMK2D0.59884080
102AKT30.59498593
103CAMK40.59363498
104PTK20.58318326
105PRKAA10.57830715
106FGFR10.57400229
107PAK10.57391007
108PRKCZ0.57240819
109CSNK1E0.56375236
110CAMKK10.56342417
111CAMKK20.56280831
112MARK20.55083526
113MAP3K40.53541351
114PRKCI0.52791713
115CAMK2A0.52616531
116MELK0.51595714
117BMX0.49817007
118EPHA20.49646527
119STK110.49546990
120PRKCG0.49528450
121PRKCE0.49472163
122MAP2K20.48285685
123DYRK1B0.48053373
124CSNK1D0.47242926
125TRIM280.47024372
126MAP3K60.46921387
127RPS6KA50.45170919
128ACVR1B0.44374327
129PLK10.44003994
130CDK80.43980429
131CLK10.43900929
132PLK30.43611655
133MAPK90.42667118
134BCKDK0.41176073
135BMPR20.40766972
136SRC0.40315762
137ALK0.38926784
138CDK10.37770569
139CAMK2G0.37690204
140PASK0.37486640
141MAP2K70.36626003
142FER0.35261549
143SIK30.34423910
144CAMK1D0.34046519
145PRKAA20.33980196
146CDK20.33941529
147GSK3B0.32984409
148TAOK10.31378944

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.68100809
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.59347692
3Fat digestion and absorption_Homo sapiens_hsa049753.33302843
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.95048348
5Arginine biosynthesis_Homo sapiens_hsa002202.76695047
6Steroid biosynthesis_Homo sapiens_hsa001002.70985662
7* Axon guidance_Homo sapiens_hsa043602.61690949
8Hedgehog signaling pathway_Homo sapiens_hsa043402.56116370
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52648128
10RNA polymerase_Homo sapiens_hsa030202.47905652
11Vitamin digestion and absorption_Homo sapiens_hsa049772.42305900
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.41697077
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32040237
14Basal cell carcinoma_Homo sapiens_hsa052172.31101191
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26510878
16Proteasome_Homo sapiens_hsa030502.17130208
17Fructose and mannose metabolism_Homo sapiens_hsa000512.14057751
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14001359
19Spliceosome_Homo sapiens_hsa030402.11886367
20Renin-angiotensin system_Homo sapiens_hsa046142.00308328
21Bile secretion_Homo sapiens_hsa049761.89891012
22Oxidative phosphorylation_Homo sapiens_hsa001901.85918713
23Biosynthesis of amino acids_Homo sapiens_hsa012301.81923722
24Ribosome_Homo sapiens_hsa030101.79224492
25Arginine and proline metabolism_Homo sapiens_hsa003301.79179067
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73304129
27Starch and sucrose metabolism_Homo sapiens_hsa005001.72759603
28Hippo signaling pathway_Homo sapiens_hsa043901.61840745
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58739169
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56407953
31Galactose metabolism_Homo sapiens_hsa000521.56022930
32PPAR signaling pathway_Homo sapiens_hsa033201.55819894
33Parkinsons disease_Homo sapiens_hsa050121.55547027
34Ether lipid metabolism_Homo sapiens_hsa005651.55525645
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54045442
36Sulfur relay system_Homo sapiens_hsa041221.53229543
37Nicotine addiction_Homo sapiens_hsa050331.51519634
38Fatty acid biosynthesis_Homo sapiens_hsa000611.50518445
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48093244
40Renal cell carcinoma_Homo sapiens_hsa052111.45775927
41Histidine metabolism_Homo sapiens_hsa003401.45528758
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44788610
43Wnt signaling pathway_Homo sapiens_hsa043101.42461087
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42051917
45Basal transcription factors_Homo sapiens_hsa030221.41333520
46mRNA surveillance pathway_Homo sapiens_hsa030151.41200233
47Serotonergic synapse_Homo sapiens_hsa047261.37956693
48Long-term depression_Homo sapiens_hsa047301.37848592
49Phenylalanine metabolism_Homo sapiens_hsa003601.37791505
50Glutamatergic synapse_Homo sapiens_hsa047241.37257106
51Complement and coagulation cascades_Homo sapiens_hsa046101.36351931
52Gap junction_Homo sapiens_hsa045401.35595570
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35555589
54Retinol metabolism_Homo sapiens_hsa008301.35141569
55Protein digestion and absorption_Homo sapiens_hsa049741.33432321
56RNA transport_Homo sapiens_hsa030131.30814378
57Alzheimers disease_Homo sapiens_hsa050101.30240632
58Oocyte meiosis_Homo sapiens_hsa041141.28134458
59Sulfur metabolism_Homo sapiens_hsa009201.27981388
60Huntingtons disease_Homo sapiens_hsa050161.27722074
61Melanogenesis_Homo sapiens_hsa049161.25274830
62Fatty acid metabolism_Homo sapiens_hsa012121.23709230
63Cardiac muscle contraction_Homo sapiens_hsa042601.22742793
64Tight junction_Homo sapiens_hsa045301.21492166
65Protein export_Homo sapiens_hsa030601.19202228
66GABAergic synapse_Homo sapiens_hsa047271.17560055
67Fatty acid degradation_Homo sapiens_hsa000711.14040526
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11874516
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09451995
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09237108
71Mineral absorption_Homo sapiens_hsa049781.08570942
72Drug metabolism - other enzymes_Homo sapiens_hsa009831.07673829
73Fatty acid elongation_Homo sapiens_hsa000621.05686536
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05600022
75Carbon metabolism_Homo sapiens_hsa012001.03930340
76Dopaminergic synapse_Homo sapiens_hsa047281.02002304
77Notch signaling pathway_Homo sapiens_hsa043301.01631524
78AMPK signaling pathway_Homo sapiens_hsa041521.00522612
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00436429
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00029277
81Phototransduction_Homo sapiens_hsa047440.98040233
82Cell cycle_Homo sapiens_hsa041100.95602458
83Morphine addiction_Homo sapiens_hsa050320.93959841
84Cocaine addiction_Homo sapiens_hsa050300.92665436
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.90244290
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90013970
87Long-term potentiation_Homo sapiens_hsa047200.89950232
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.89616925
89Thyroid hormone synthesis_Homo sapiens_hsa049180.88313178
90Dorso-ventral axis formation_Homo sapiens_hsa043200.87481333
91Alcoholism_Homo sapiens_hsa050340.84347371
92MicroRNAs in cancer_Homo sapiens_hsa052060.84189396
93ErbB signaling pathway_Homo sapiens_hsa040120.83730133
94Lysine degradation_Homo sapiens_hsa003100.81488901
95Circadian entrainment_Homo sapiens_hsa047130.80789245
96Caffeine metabolism_Homo sapiens_hsa002320.80270608
97Sphingolipid metabolism_Homo sapiens_hsa006000.79869752
98Cholinergic synapse_Homo sapiens_hsa047250.79276294
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79091984
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78533911
101Nucleotide excision repair_Homo sapiens_hsa034200.78216234
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77913298
103TGF-beta signaling pathway_Homo sapiens_hsa043500.76012704
104Olfactory transduction_Homo sapiens_hsa047400.75896752
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.75078139
106Tyrosine metabolism_Homo sapiens_hsa003500.74861098
107Amphetamine addiction_Homo sapiens_hsa050310.74576109
108Adherens junction_Homo sapiens_hsa045200.73499280
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72605725
110Taste transduction_Homo sapiens_hsa047420.71064694
111Melanoma_Homo sapiens_hsa052180.70423315
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70297993
113* Ras signaling pathway_Homo sapiens_hsa040140.70179114
114Pyruvate metabolism_Homo sapiens_hsa006200.70055990
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69672013
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69343123
117Oxytocin signaling pathway_Homo sapiens_hsa049210.68805949
118Chemical carcinogenesis_Homo sapiens_hsa052040.67807990
119Glucagon signaling pathway_Homo sapiens_hsa049220.67774104
120Choline metabolism in cancer_Homo sapiens_hsa052310.67736350
121Vibrio cholerae infection_Homo sapiens_hsa051100.66631063
122Nitrogen metabolism_Homo sapiens_hsa009100.66449482
123Prion diseases_Homo sapiens_hsa050200.66135250
124MAPK signaling pathway_Homo sapiens_hsa040100.65767799
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61930076
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61057147
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61042604
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.59896328
129GnRH signaling pathway_Homo sapiens_hsa049120.59814114
130Mismatch repair_Homo sapiens_hsa034300.59288052
131Prostate cancer_Homo sapiens_hsa052150.58668286
132Linoleic acid metabolism_Homo sapiens_hsa005910.58150225
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58135479
134Synaptic vesicle cycle_Homo sapiens_hsa047210.56882962
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56285078
136Bladder cancer_Homo sapiens_hsa052190.56110419
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55834294
138Insulin signaling pathway_Homo sapiens_hsa049100.55273294
139Glioma_Homo sapiens_hsa052140.54080920
140Insulin secretion_Homo sapiens_hsa049110.54063388
141Renin secretion_Homo sapiens_hsa049240.52695530
142Colorectal cancer_Homo sapiens_hsa052100.51873378
143Estrogen signaling pathway_Homo sapiens_hsa049150.51474736
144Glycerolipid metabolism_Homo sapiens_hsa005610.51330605
145Pathways in cancer_Homo sapiens_hsa052000.50872073
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50492421
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50357789
148Endometrial cancer_Homo sapiens_hsa052130.49730700
149Collecting duct acid secretion_Homo sapiens_hsa049660.49157732
150Pyrimidine metabolism_Homo sapiens_hsa002400.48898478
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.48411024
152Proteoglycans in cancer_Homo sapiens_hsa052050.47209640
153Endocytosis_Homo sapiens_hsa041440.46790599
154RNA degradation_Homo sapiens_hsa030180.45410690
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44999212
156Vitamin B6 metabolism_Homo sapiens_hsa007500.44965278
157Homologous recombination_Homo sapiens_hsa034400.44357947
158Pentose phosphate pathway_Homo sapiens_hsa000300.42718660
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42711545
160Insulin resistance_Homo sapiens_hsa049310.41839464
161Ovarian steroidogenesis_Homo sapiens_hsa049130.40962221
162Peroxisome_Homo sapiens_hsa041460.40918733
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.40728988
164Butanoate metabolism_Homo sapiens_hsa006500.40717848
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36434713
166Adipocytokine signaling pathway_Homo sapiens_hsa049200.34973926
167Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34922753
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33215842
169Tryptophan metabolism_Homo sapiens_hsa003800.32516176
170Thyroid cancer_Homo sapiens_hsa052160.31720989
171ABC transporters_Homo sapiens_hsa020100.30944809
172Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30295514
173Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27989043
174N-Glycan biosynthesis_Homo sapiens_hsa005100.27370397
175Arachidonic acid metabolism_Homo sapiens_hsa005900.24573852

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