EFNA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03340764
2synaptic vesicle maturation (GO:0016188)5.60801072
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51422634
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37284395
5vocalization behavior (GO:0071625)5.27784753
6locomotory exploration behavior (GO:0035641)5.22610631
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.18896339
8glutamate secretion (GO:0014047)5.06141437
9synaptic vesicle exocytosis (GO:0016079)5.04827225
10regulation of glutamate receptor signaling pathway (GO:1900449)4.98918389
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.96944741
12establishment of mitochondrion localization (GO:0051654)4.93491855
13layer formation in cerebral cortex (GO:0021819)4.71172953
14protein localization to synapse (GO:0035418)4.70571264
15pyrimidine nucleobase catabolic process (GO:0006208)4.69520005
16dendritic spine morphogenesis (GO:0060997)4.64760065
17regulation of synaptic vesicle exocytosis (GO:2000300)4.58299602
18regulation of neuronal synaptic plasticity (GO:0048168)4.50726865
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.49847495
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49653575
21exploration behavior (GO:0035640)4.39575114
22neuron cell-cell adhesion (GO:0007158)4.32856275
23positive regulation of synapse maturation (GO:0090129)4.29757145
24regulation of synapse structural plasticity (GO:0051823)4.23982944
25mitochondrion transport along microtubule (GO:0047497)4.23126042
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.23126042
27regulation of synaptic vesicle transport (GO:1902803)4.12819083
28sensory perception of smell (GO:0007608)4.05552335
29cerebellar granule cell differentiation (GO:0021707)4.03893005
30synaptic transmission, glutamatergic (GO:0035249)4.02490849
31glutamate receptor signaling pathway (GO:0007215)4.00045213
32neurotransmitter secretion (GO:0007269)3.97917988
33axonal fasciculation (GO:0007413)3.95314791
34neuron recognition (GO:0008038)3.90614378
35dendritic spine organization (GO:0097061)3.84752290
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76781072
37regulation of dendritic spine morphogenesis (GO:0061001)3.74732143
38cell migration in hindbrain (GO:0021535)3.74493924
39neuronal action potential propagation (GO:0019227)3.71284517
40nucleobase catabolic process (GO:0046113)3.63075407
41neurotransmitter-gated ion channel clustering (GO:0072578)3.62201924
42regulation of synaptic plasticity (GO:0048167)3.61834020
43neuron-neuron synaptic transmission (GO:0007270)3.61666491
44long-term memory (GO:0007616)3.59096882
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54900118
46positive regulation of membrane potential (GO:0045838)3.49844794
47chemosensory behavior (GO:0007635)3.49798960
48activation of protein kinase A activity (GO:0034199)3.49600635
49desmosome organization (GO:0002934)3.47084297
50neuromuscular process controlling balance (GO:0050885)3.42785532
51neurofilament cytoskeleton organization (GO:0060052)3.42721520
52dendrite morphogenesis (GO:0048813)3.42627358
53auditory behavior (GO:0031223)3.37789228
54regulation of postsynaptic membrane potential (GO:0060078)3.35232289
55proline transport (GO:0015824)3.33840082
56regulation of vesicle fusion (GO:0031338)3.32638373
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.32482886
58substrate-independent telencephalic tangential migration (GO:0021826)3.32482886
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.32172578
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30341233
61positive regulation of dendritic spine development (GO:0060999)3.28392674
62central nervous system projection neuron axonogenesis (GO:0021952)3.27214800
63cellular potassium ion homeostasis (GO:0030007)3.26308214
64gamma-aminobutyric acid transport (GO:0015812)3.21321153
65regulation of dendritic spine development (GO:0060998)3.21074721
66behavioral defense response (GO:0002209)3.20754796
67behavioral fear response (GO:0001662)3.20754796
68synaptic vesicle endocytosis (GO:0048488)3.16757814
69positive regulation of neurotransmitter secretion (GO:0001956)3.16020693
70regulation of synapse maturation (GO:0090128)3.13570373
71postsynaptic membrane organization (GO:0001941)3.12687919
72cerebellar Purkinje cell differentiation (GO:0021702)3.12643804
73regulation of neurotransmitter secretion (GO:0046928)3.11849130
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11165095
75cell differentiation in hindbrain (GO:0021533)3.10793932
76neurotransmitter transport (GO:0006836)3.09919881
77positive regulation of synapse assembly (GO:0051965)3.09551381
78innervation (GO:0060384)3.07165659
79* ephrin receptor signaling pathway (GO:0048013)3.07084018
80presynaptic membrane organization (GO:0097090)3.06888660
81positive regulation of neurotransmitter transport (GO:0051590)3.05278351
82negative regulation of microtubule polymerization (GO:0031115)3.04907149
83sodium ion export (GO:0071436)3.04538196
84long-term synaptic potentiation (GO:0060291)3.04011711
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03799457
86transmission of nerve impulse (GO:0019226)3.01984439
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01519883
88cell-cell junction maintenance (GO:0045217)3.00776232
89keratinization (GO:0031424)2.98287125
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96705372
91response to auditory stimulus (GO:0010996)2.95824311
92social behavior (GO:0035176)2.95670622
93intraspecies interaction between organisms (GO:0051703)2.95670622
94dopamine receptor signaling pathway (GO:0007212)2.95194612
95fear response (GO:0042596)2.93908588
96learning (GO:0007612)2.92581544
97establishment of skin barrier (GO:0061436)2.92206649
98synapse assembly (GO:0007416)2.90426191
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.89849926
100vesicle transport along microtubule (GO:0047496)2.89745389
101neuronal ion channel clustering (GO:0045161)2.89648363
102axon extension (GO:0048675)2.89070639
103cell communication by electrical coupling (GO:0010644)2.88090700
104behavioral response to cocaine (GO:0048148)2.85847236
105regulation of neurotransmitter transport (GO:0051588)2.85617614
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.84822174
107regulation of neurotransmitter levels (GO:0001505)2.84770529
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84496209
109regulation of synaptic transmission (GO:0050804)2.83017710
110membrane depolarization (GO:0051899)2.82941931
111behavioral response to nicotine (GO:0035095)2.82780691
112prepulse inhibition (GO:0060134)2.81377643
113neuromuscular process (GO:0050905)2.79819946
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78177044
115regulation of clathrin-mediated endocytosis (GO:2000369)2.77060572
116positive regulation of vesicle fusion (GO:0031340)2.76964707
117mechanosensory behavior (GO:0007638)2.70635196
118regulation of water loss via skin (GO:0033561)2.68612611
119neuron projection extension (GO:1990138)2.65314924
120presynaptic membrane assembly (GO:0097105)2.59704076
121cell junction maintenance (GO:0034331)2.59627014
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53933935
123synapse organization (GO:0050808)2.49164678
124peptidyl-arginine omega-N-methylation (GO:0035247)2.47769630
125protein insertion into membrane (GO:0051205)2.45566595
126respiratory system process (GO:0003016)2.44301826
127spinal cord association neuron differentiation (GO:0021527)2.41784535
128adult walking behavior (GO:0007628)2.41564228
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.41230367
130axon extension involved in axon guidance (GO:0048846)2.41230367
131body morphogenesis (GO:0010171)2.41184186
132cellular component maintenance (GO:0043954)2.39703933
133central nervous system myelination (GO:0022010)2.37611924
134axon ensheathment in central nervous system (GO:0032291)2.37611924
135viral transcription (GO:0019083)2.37227258
136retinal ganglion cell axon guidance (GO:0031290)2.36338141
137ganglion development (GO:0061548)2.36275989
138regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.35448974
139dendrite development (GO:0016358)2.34496318
140axon cargo transport (GO:0008088)2.33639932
141cerebellar Purkinje cell layer development (GO:0021680)2.32394239
142neuromuscular synaptic transmission (GO:0007274)2.28101317
143establishment of tissue polarity (GO:0007164)2.28045197
144establishment of planar polarity (GO:0001736)2.28045197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23437566
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23024000
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99788916
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91218067
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90277625
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90277625
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86185330
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.67542355
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.59425293
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57087421
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56657273
12REST_21632747_ChIP-Seq_MESCs_Mouse2.54042036
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51113582
14* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48482313
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47583015
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.45105291
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41133848
18DROSHA_22980978_ChIP-Seq_HELA_Human2.40682480
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40000053
20GBX2_23144817_ChIP-Seq_PC3_Human2.36281566
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35381100
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.34331889
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.33003480
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29043109
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.13315131
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07442434
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.07062677
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06909789
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90898960
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86502233
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85961788
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79068819
33* RING1B_27294783_Chip-Seq_ESCs_Mouse1.69696651
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62730316
35* KDM2B_26808549_Chip-Seq_K562_Human1.55656034
36SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54925331
37* RING1B_27294783_Chip-Seq_NPCs_Mouse1.53378478
38AR_21572438_ChIP-Seq_LNCaP_Human1.51678755
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50131660
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48924802
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46886452
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46210482
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46140027
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.45521966
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43080405
46XRN2_22483619_ChIP-Seq_HELA_Human1.40921395
47* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38650326
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37700652
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35409629
50CREB1_26743006_Chip-Seq_LNCaP_Human1.34507814
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.33886551
52* P68_20966046_ChIP-Seq_HELA_Human1.32900844
53CTCF_27219007_Chip-Seq_Bcells_Human1.32503227
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31685912
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30770714
56ZNF263_19887448_ChIP-Seq_K562_Human1.30576700
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29548275
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29250741
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29203813
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27342334
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25719882
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22127162
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22105439
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20057857
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.19964135
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.18768811
67* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16788808
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16240767
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.15377362
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14985582
71ZNF274_21170338_ChIP-Seq_K562_Hela1.14010164
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13856036
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13349222
74AHR_22903824_ChIP-Seq_MCF-7_Human1.12280363
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09901809
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09078268
77RNF2_27304074_Chip-Seq_NSC_Mouse1.07769323
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07259196
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07101910
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06999034
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05164954
82* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04918337
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04879180
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.04448785
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.04085726
86* LXR_22292898_ChIP-Seq_THP-1_Human1.03282458
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03123805
88AR_19668381_ChIP-Seq_PC3_Human1.02969057
89SMAD4_21799915_ChIP-Seq_A2780_Human1.02121961
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.00840657
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00469963
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.00348855
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97553962
94TET1_21490601_ChIP-Seq_MESCs_Mouse0.97519601
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.96473594
96* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95938225
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95263568
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.94833507
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94621444
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.93858530
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93736700
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93383363
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93281178
104SA1_27219007_Chip-Seq_Bcells_Human0.90099338
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90048172
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89252551
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.88270563
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88023833
109NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87966132
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.87803583
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87729040
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86903443
113MYC_18555785_ChIP-Seq_MESCs_Mouse0.86132884
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85971643
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85867132
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85799783
117SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85635690
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85531153
119PHF8_20622854_ChIP-Seq_HELA_Human0.84116341
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84102121
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84079475
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82659405
123SMC4_20622854_ChIP-Seq_HELA_Human0.82412389
124* KDM2B_26808549_Chip-Seq_DND41_Human0.82279676
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81972956
126TP53_18474530_ChIP-ChIP_U2OS_Human0.81907072
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79394455
128AR_25329375_ChIP-Seq_VCAP_Human0.79101014
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78658961
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78258221
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77906702
132TAF15_26573619_Chip-Seq_HEK293_Human0.77768978
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77693726
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.76948919
135* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76862200
136OCT4_19829295_ChIP-Seq_ESCs_Human0.76381438
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75470041
138* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74392482
139MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74269590
140* KDM2B_26808549_Chip-Seq_JURKAT_Human0.73889003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58081646
2MP0003880_abnormal_central_pattern4.32240016
3* MP0003635_abnormal_synaptic_transmissio3.85670270
4MP0004270_analgesia3.46409661
5MP0001984_abnormal_olfaction3.33241052
6* MP0002063_abnormal_learning/memory/cond3.18393847
7MP0003123_paternal_imprinting3.12243154
8MP0009745_abnormal_behavioral_response2.92402975
9MP0002064_seizures2.59825346
10MP0002822_catalepsy2.56648897
11MP0006292_abnormal_olfactory_placode2.49721807
12MP0009379_abnormal_foot_pigmentation2.49474807
13MP0002796_impaired_skin_barrier2.49065932
14MP0010234_abnormal_vibrissa_follicle2.48075416
15* MP0002572_abnormal_emotion/affect_behav2.40553285
16MP0000566_synostosis2.36721055
17MP0001968_abnormal_touch/_nociception2.31437398
18MP0005423_abnormal_somatic_nervous2.30261262
19MP0004858_abnormal_nervous_system2.27450137
20MP0002734_abnormal_mechanical_nocicepti2.21609783
21MP0001486_abnormal_startle_reflex2.21474381
22MP0009046_muscle_twitch2.20323931
23MP0005499_abnormal_olfactory_system2.04248889
24MP0005394_taste/olfaction_phenotype2.04248889
25MP0000778_abnormal_nervous_system2.03569944
26MP0002184_abnormal_innervation2.03555838
27MP0002272_abnormal_nervous_system1.97897961
28MP0001440_abnormal_grooming_behavior1.81195247
29MP0004811_abnormal_neuron_physiology1.77381288
30MP0002733_abnormal_thermal_nociception1.74514595
31MP0003121_genomic_imprinting1.73020053
32MP0003329_amyloid_beta_deposits1.71172942
33MP0001501_abnormal_sleep_pattern1.69985353
34MP0002735_abnormal_chemical_nociception1.67393298
35MP0002736_abnormal_nociception_after1.65349449
36* MP0002557_abnormal_social/conspecific_i1.59607512
37MP0001970_abnormal_pain_threshold1.59605606
38MP0009780_abnormal_chondrocyte_physiolo1.52974627
39MP0000955_abnormal_spinal_cord1.52099140
40MP0000579_abnormal_nail_morphology1.51352920
41MP0008789_abnormal_olfactory_epithelium1.43740275
42MP0002067_abnormal_sensory_capabilities1.42011507
43* MP0002882_abnormal_neuron_morphology1.41374734
44MP0005275_abnormal_skin_tensile1.38850730
45MP0008569_lethality_at_weaning1.35073220
46MP0002909_abnormal_adrenal_gland1.32848506
47MP0003315_abnormal_perineum_morphology1.32372391
48MP0002234_abnormal_pharynx_morphology1.31262091
49MP0004885_abnormal_endolymph1.27095478
50MP0005501_abnormal_skin_physiology1.26974983
51MP0003879_abnormal_hair_cell1.23817657
52MP0006276_abnormal_autonomic_nervous1.21281536
53MP0003941_abnormal_skin_development1.21022589
54MP0001188_hyperpigmentation1.19860615
55* MP0002152_abnormal_brain_morphology1.18863216
56MP0005409_darkened_coat_color1.18757493
57MP0002066_abnormal_motor_capabilities/c1.17734078
58MP0003283_abnormal_digestive_organ1.17252907
59MP0004924_abnormal_behavior1.16154733
60MP0005386_behavior/neurological_phenoty1.16154733
61MP0002098_abnormal_vibrissa_morphology1.14629524
62MP0003119_abnormal_digestive_system1.12982733
63MP0008961_abnormal_basal_metabolism1.10575147
64MP0002249_abnormal_larynx_morphology1.10353477
65MP0005645_abnormal_hypothalamus_physiol1.02989448
66MP0002653_abnormal_ependyma_morphology1.02751223
67MP0005623_abnormal_meninges_morphology1.01850991
68MP0000049_abnormal_middle_ear0.99746651
69MP0003787_abnormal_imprinting0.98013882
70* MP0003861_abnormal_nervous_system0.97594484
71MP0004142_abnormal_muscle_tone0.95448659
72MP0002254_reproductive_system_inflammat0.93709528
73MP0010771_integument_phenotype0.92887677
74MP0010030_abnormal_orbit_morphology0.92064751
75MP0001529_abnormal_vocalization0.90331371
76MP0002229_neurodegeneration0.89846147
77MP0002752_abnormal_somatic_nervous0.89630708
78MP0003942_abnormal_urinary_system0.88999392
79MP0000762_abnormal_tongue_morphology0.86990566
80MP0000467_abnormal_esophagus_morphology0.86162400
81MP0003122_maternal_imprinting0.84833155
82MP0004133_heterotaxia0.84613022
83MP0001502_abnormal_circadian_rhythm0.83566838
84MP0000751_myopathy0.82613122
85MP0003633_abnormal_nervous_system0.82284247
86MP0001177_atelectasis0.82128587
87MP0008877_abnormal_DNA_methylation0.80984438
88MP0002069_abnormal_eating/drinking_beha0.80795219
89MP0000647_abnormal_sebaceous_gland0.78456864
90MP0003631_nervous_system_phenotype0.77646733
91MP0003890_abnormal_embryonic-extraembry0.76926984
92MP0003136_yellow_coat_color0.76639723
93MP0000377_abnormal_hair_follicle0.75359401
94MP0004185_abnormal_adipocyte_glucose0.75317937
95MP0001346_abnormal_lacrimal_gland0.74578491
96MP0003705_abnormal_hypodermis_morpholog0.74394055
97MP0003938_abnormal_ear_development0.74173737
98MP0009053_abnormal_anal_canal0.73599245
99MP0003075_altered_response_to0.73111687
100MP0001905_abnormal_dopamine_level0.71288520
101MP0005551_abnormal_eye_electrophysiolog0.71172794
102MP0000427_abnormal_hair_cycle0.70985185
103MP0002160_abnormal_reproductive_system0.70073844
104MP0003385_abnormal_body_wall0.69510208
105MP0000534_abnormal_ureter_morphology0.69291603
106MP0005248_abnormal_Harderian_gland0.67236235
107MP0004381_abnormal_hair_follicle0.65687272
108MP0008874_decreased_physiological_sensi0.65649462
109MP0003878_abnormal_ear_physiology0.65486312
110MP0005377_hearing/vestibular/ear_phenot0.65486312
111MP0001293_anophthalmia0.65457091
112MP0010678_abnormal_skin_adnexa0.65175700
113MP0004742_abnormal_vestibular_system0.65020752
114MP0005187_abnormal_penis_morphology0.64996070
115MP0000631_abnormal_neuroendocrine_gland0.64588102
116MP0004233_abnormal_muscle_weight0.64292244
117MP0002081_perinatal_lethality0.64052956
118MP0005646_abnormal_pituitary_gland0.63491653
119MP0003755_abnormal_palate_morphology0.63393063
120MP0001485_abnormal_pinna_reflex0.61786666
121MP0001963_abnormal_hearing_physiology0.61028340
122MP0003632_abnormal_nervous_system0.60605945
123MP0000537_abnormal_urethra_morphology0.60474807
124MP0002233_abnormal_nose_morphology0.58464390
125MP0008872_abnormal_physiological_respon0.58320991
126MP0000026_abnormal_inner_ear0.57348519
127MP0004145_abnormal_muscle_electrophysio0.56685528

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.43930038
2Focal motor seizures (HP:0011153)5.92424532
3Focal seizures (HP:0007359)4.75422950
4Visual hallucinations (HP:0002367)4.30536451
5Atonic seizures (HP:0010819)3.67198432
6Epileptic encephalopathy (HP:0200134)3.61896795
7Absence seizures (HP:0002121)3.36075192
8Febrile seizures (HP:0002373)3.28118142
9Supranuclear gaze palsy (HP:0000605)3.26500278
10Amblyopia (HP:0000646)3.26310336
11Abnormality of the lower motor neuron (HP:0002366)3.24871878
12Progressive cerebellar ataxia (HP:0002073)3.22994307
13Ankle clonus (HP:0011448)3.08277238
14Generalized tonic-clonic seizures (HP:0002069)3.07949121
15Hypotrichosis (HP:0001006)3.07883067
16Dialeptic seizures (HP:0011146)3.03127305
17Polyphagia (HP:0002591)3.00761313
18Mutism (HP:0002300)2.93820801
19Abnormality of the corticospinal tract (HP:0002492)2.85970702
20Torticollis (HP:0000473)2.78494466
21Action tremor (HP:0002345)2.77578016
22Broad-based gait (HP:0002136)2.77406832
23Ventricular fibrillation (HP:0001663)2.75059577
24Megalencephaly (HP:0001355)2.66444216
25Impaired vibration sensation in the lower limbs (HP:0002166)2.63983235
26Dysdiadochokinesis (HP:0002075)2.56073254
27Depression (HP:0000716)2.55635376
28Focal dystonia (HP:0004373)2.50307194
29Congenital ichthyosiform erythroderma (HP:0007431)2.50106287
30Poor eye contact (HP:0000817)2.49787551
31Fragile nails (HP:0001808)2.48670666
32Obstructive sleep apnea (HP:0002870)2.47715650
33Annular pancreas (HP:0001734)2.45882625
34Genetic anticipation (HP:0003743)2.45557464
35Cerebral inclusion bodies (HP:0100314)2.43455526
36Ankyloglossia (HP:0010296)2.39982124
37Limb dystonia (HP:0002451)2.37869857
38Abnormal social behavior (HP:0012433)2.35434664
39Impaired social interactions (HP:0000735)2.35434664
40Urinary bladder sphincter dysfunction (HP:0002839)2.28993278
41Gait imbalance (HP:0002141)2.28771895
42Craniofacial dystonia (HP:0012179)2.27301842
43Drooling (HP:0002307)2.26840971
44Excessive salivation (HP:0003781)2.26840971
45Dysmetria (HP:0001310)2.25965760
46Woolly hair (HP:0002224)2.24708544
47Bronchomalacia (HP:0002780)2.24520944
48Anosmia (HP:0000458)2.24089531
49Stereotypic behavior (HP:0000733)2.23282390
50Postural instability (HP:0002172)2.23217687
51Anxiety (HP:0000739)2.22801499
52Poor suck (HP:0002033)2.22243015
53Hemiparesis (HP:0001269)2.21641400
54Plantar hyperkeratosis (HP:0007556)2.21379067
55Abnormal eating behavior (HP:0100738)2.21166730
56Abnormality of hair growth rate (HP:0011363)2.19110959
57Slow-growing hair (HP:0002217)2.19110959
58Delusions (HP:0000746)2.18901257
59Septate vagina (HP:0001153)2.16817921
60Urinary urgency (HP:0000012)2.15027213
61Pointed chin (HP:0000307)2.14939847
62Intention tremor (HP:0002080)2.13439242
63Insomnia (HP:0100785)2.11121677
64Morphological abnormality of the pyramidal tract (HP:0002062)2.10630347
65Achilles tendon contracture (HP:0001771)2.10364547
66Hyperthyroidism (HP:0000836)2.09128265
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04288868
68Hypoplasia of the brainstem (HP:0002365)2.04288868
69Apathy (HP:0000741)2.04154144
70Split foot (HP:0001839)2.04135022
71Neurofibrillary tangles (HP:0002185)2.03821717
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02499668
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.02499668
74Palmoplantar hyperkeratosis (HP:0000972)2.00391315
75Hyperventilation (HP:0002883)1.98909324
76Truncus arteriosus (HP:0001660)1.97502927
77Amyotrophic lateral sclerosis (HP:0007354)1.95250306
78Truncal ataxia (HP:0002078)1.94847144
79Aplasia involving bones of the upper limbs (HP:0009823)1.93770487
80Aplasia of the phalanges of the hand (HP:0009802)1.93770487
81Aplasia involving bones of the extremities (HP:0009825)1.93770487
82Type II lissencephaly (HP:0007260)1.93369753
83Impaired smooth pursuit (HP:0007772)1.92208345
84Gaze-evoked nystagmus (HP:0000640)1.91489950
85Papilledema (HP:0001085)1.90981264
86Lissencephaly (HP:0001339)1.90897918
87Insidious onset (HP:0003587)1.90215717
88Termporal pattern (HP:0011008)1.90215717
89Bradykinesia (HP:0002067)1.88723968
90Erythroderma (HP:0001019)1.87494477
91Spastic gait (HP:0002064)1.86563753
92Cerebral hypomyelination (HP:0006808)1.86462711
93Agitation (HP:0000713)1.86300799
94Onycholysis (HP:0001806)1.85384378
95Abnormality of the Achilles tendon (HP:0005109)1.85303447
96Hypsarrhythmia (HP:0002521)1.85178940
97Reticulocytopenia (HP:0001896)1.84693267
98Palmar hyperkeratosis (HP:0010765)1.84411648
99Abnormality of binocular vision (HP:0011514)1.84318705
100Diplopia (HP:0000651)1.84318705
101Diminished motivation (HP:0000745)1.84100240
102Akinesia (HP:0002304)1.83028784
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82387937
104EEG with generalized epileptiform discharges (HP:0011198)1.81783841
105Oligodactyly (HP:0012165)1.81766525
106Fetal akinesia sequence (HP:0001989)1.81560599
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81510298
108Lower limb amyotrophy (HP:0007210)1.80945420
109Epileptiform EEG discharges (HP:0011182)1.79712324
110Abnormality of the aortic arch (HP:0012303)1.79541078
111Hamartoma of the eye (HP:0010568)1.78653318
112Curly hair (HP:0002212)1.78606147
113Milia (HP:0001056)1.78539663
114Pili torti (HP:0003777)1.77957131
115Deep palmar crease (HP:0006191)1.77126746
116Pachygyria (HP:0001302)1.75183641
117Rapidly progressive (HP:0003678)1.73527105
118Spastic tetraplegia (HP:0002510)1.73194082
119Aqueductal stenosis (HP:0002410)1.72169270
120Ulnar claw (HP:0001178)1.72114773
121Abnormality of nail color (HP:0100643)1.71634889
122Hemiplegia (HP:0002301)1.70513358
123Congenital primary aphakia (HP:0007707)1.69821616
124Right ventricular cardiomyopathy (HP:0011663)1.69596795
125Retinal dysplasia (HP:0007973)1.69587067
126Lower limb muscle weakness (HP:0007340)1.69340787
127Progressive inability to walk (HP:0002505)1.68955665
128Abnormality of cells of the erythroid lineage (HP:0012130)1.68192209
129Sudden death (HP:0001699)1.67716458
130Concave nail (HP:0001598)1.65609450
131Rib fusion (HP:0000902)1.65355520
132Impaired vibratory sensation (HP:0002495)1.65209176
133High anterior hairline (HP:0009890)1.65017779
134Nephrogenic diabetes insipidus (HP:0009806)1.64976810
135Failure to thrive in infancy (HP:0001531)1.64396001
136Ependymoma (HP:0002888)1.64040842
137Cerebellar dysplasia (HP:0007033)1.63875248
138Cortical dysplasia (HP:0002539)1.62332213
139Partial duplication of thumb phalanx (HP:0009944)1.61891545
140CNS hypomyelination (HP:0003429)1.61549664
141Hand muscle atrophy (HP:0009130)1.61083799
142Abnormal hair laboratory examination (HP:0003328)1.60608057
143Abnormality of reticulocytes (HP:0004312)1.59906256
144Sleep apnea (HP:0010535)1.59515052
145Specific learning disability (HP:0001328)1.58947615
146Long palpebral fissure (HP:0000637)1.56148850
147Renal dysplasia (HP:0000110)1.54702210
148Abnormality of the labia minora (HP:0012880)1.52935654
149Oligodactyly (hands) (HP:0001180)1.52686943
150Anomalous pulmonary venous return (HP:0010772)1.50598382
151Shawl scrotum (HP:0000049)1.50538738
152Abnormality of glycolysis (HP:0004366)1.50313973
153Status epilepticus (HP:0002133)1.50076894
154Abnormality of the salivary glands (HP:0010286)1.50018773
155Hypoplasia of the corpus callosum (HP:0002079)1.48858501
156Abnormal mitochondria in muscle tissue (HP:0008316)1.48559526
157Reticulocytosis (HP:0001923)1.48165040
158Labial hypoplasia (HP:0000066)1.46628937
159Acute necrotizing encephalopathy (HP:0006965)1.43629039
160Morphological abnormality of the middle ear (HP:0008609)1.43591651
161Hyperacusis (HP:0010780)1.43006487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.73241496
2MAP3K94.14792094
3NTRK33.98086049
4MARK13.63317227
5MINK12.62824669
6DAPK22.58548759
7LATS22.45854656
8MAP3K42.45227373
9NTRK22.28142296
10KSR22.22078272
11PAK62.21551732
12PRKD32.17133115
13EPHA22.16912727
14KSR11.89945214
15TYRO31.87796432
16TESK11.80348609
17MAP2K41.75993555
18MAP2K71.74104143
19MAP3K121.71984167
20DAPK11.68248807
21PKN21.67870081
22EEF2K1.66944410
23NTRK11.55277981
24CAMKK11.50509923
25CDK51.47251093
26PLK21.34469620
27TAOK11.33574926
28RIPK41.30922494
29MAP3K21.30457449
30GRK51.29096808
31SIK11.29051793
32PHKG21.28328145
33PHKG11.28328145
34TESK21.27722155
35SIK21.26797632
36ARAF1.24650340
37PRKCG1.24167745
38STK381.22959045
39CDK191.21699587
40PRPF4B1.18372938
41CSNK1G31.15899015
42CASK1.15830903
43MAPK131.15586688
44FER1.14960112
45DYRK1B1.13271650
46PAK31.10756704
47UHMK11.08648238
48CSNK1A1L1.06439753
49BCR1.02696038
50MARK21.01851959
51DDR20.94661081
52CDK140.94431281
53CDK150.94366509
54CDK180.94019941
55CAMK2B0.93925086
56STK160.93121992
57ALK0.92351720
58BCKDK0.90491161
59CAMK1D0.89851025
60STK110.88133219
61WNK40.87207896
62CAMK2A0.86209289
63CDK11A0.85697305
64NME10.85434630
65PIM20.84491452
66PNCK0.84029741
67RPS6KA20.83138236
68DYRK30.83028210
69RAF10.82577486
70ERBB30.80597013
71ICK0.77984858
72TRIM280.77614155
73MAPK150.76236363
74DYRK1A0.75334591
75CAMK10.73930846
76RIPK10.73185951
77CSNK1G20.72483271
78NEK10.72121231
79AURKA0.67751077
80EPHA30.67597982
81MAP2K20.65343174
82CSNK1G10.65030787
83BRAF0.64811413
84EPHB20.63268004
85DAPK30.62225136
86MAP3K60.58742357
87CDK70.58492720
88PTK2B0.58285294
89TNIK0.58151747
90DYRK20.57168827
91NEK20.56592146
92RET0.56521026
93MAPKAPK50.56407281
94PRKCZ0.56380244
95FGR0.55978099
96MAPKAPK30.55137989
97FES0.54800906
98MAP3K110.52821483
99CAMK1G0.52469317
100RPS6KB20.51152942
101MAP2K10.51107667
102SGK10.50860534
103CAMK2G0.50199816
104BMX0.50108931
105PRKCH0.49783032
106MAP3K70.49702066
107WNK30.49693485
108NEK60.48262948
109CSNK1E0.45783812
110MAP3K10.44583199
111RPS6KA40.44099918
112LRRK20.43784512
113MAP3K130.42620191
114MAPK100.42407821
115CSNK1A10.42138176
116PDGFRA0.41904284
117MAP2K60.41540027
118CSNK1D0.41509557
119PRKD20.41054977
120LIMK10.41022583
121EPHB10.40980335
122SCYL20.40900422
123PRKCI0.40176573
124MAP4K20.40109599
125PINK10.39888424
126FYN0.39708296
127CAMK2D0.39310776
128FGFR10.37742629
129TAOK20.37693516
130AKT30.37677265
131RPS6KA30.37512094
132TRIB30.36478445
133CAMK40.36180646
134SGK4940.34650488
135SGK2230.34650488
136DMPK0.34481838
137PRKCE0.33629408

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.82503200
2Nicotine addiction_Homo sapiens_hsa050333.31159961
3Synaptic vesicle cycle_Homo sapiens_hsa047213.00054825
4Long-term potentiation_Homo sapiens_hsa047202.72787211
5Circadian entrainment_Homo sapiens_hsa047132.65755829
6Glutamatergic synapse_Homo sapiens_hsa047242.50572713
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42636664
8Amphetamine addiction_Homo sapiens_hsa050312.40703642
9GABAergic synapse_Homo sapiens_hsa047272.38820738
10Morphine addiction_Homo sapiens_hsa050322.23982567
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19171055
12Dopaminergic synapse_Homo sapiens_hsa047282.19143846
13Salivary secretion_Homo sapiens_hsa049702.12803426
14Cholinergic synapse_Homo sapiens_hsa047251.87785721
15Gastric acid secretion_Homo sapiens_hsa049711.86087500
16Ribosome_Homo sapiens_hsa030101.84168492
17Oxidative phosphorylation_Homo sapiens_hsa001901.80128161
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79094542
19Insulin secretion_Homo sapiens_hsa049111.78662552
20Oxytocin signaling pathway_Homo sapiens_hsa049211.74600687
21GnRH signaling pathway_Homo sapiens_hsa049121.74459131
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69163067
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68610669
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67743841
25Long-term depression_Homo sapiens_hsa047301.64978476
26Parkinsons disease_Homo sapiens_hsa050121.64192903
27Renin secretion_Homo sapiens_hsa049241.56891855
28Taste transduction_Homo sapiens_hsa047421.54524830
29Gap junction_Homo sapiens_hsa045401.53296117
30Serotonergic synapse_Homo sapiens_hsa047261.51278532
31Calcium signaling pathway_Homo sapiens_hsa040201.50345289
32Melanogenesis_Homo sapiens_hsa049161.49425715
33* Axon guidance_Homo sapiens_hsa043601.48182905
34Cocaine addiction_Homo sapiens_hsa050301.44783091
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40888521
36Glioma_Homo sapiens_hsa052141.36371096
37Estrogen signaling pathway_Homo sapiens_hsa049151.32754029
38Phenylalanine metabolism_Homo sapiens_hsa003601.31297995
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28788531
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26854892
41cAMP signaling pathway_Homo sapiens_hsa040241.23745334
42Alzheimers disease_Homo sapiens_hsa050101.23520979
43Steroid biosynthesis_Homo sapiens_hsa001001.23102616
44Sulfur relay system_Homo sapiens_hsa041221.17905822
45ErbB signaling pathway_Homo sapiens_hsa040121.17604472
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16001122
47Vitamin B6 metabolism_Homo sapiens_hsa007501.13057169
48Oocyte meiosis_Homo sapiens_hsa041141.12312816
49Collecting duct acid secretion_Homo sapiens_hsa049661.12294479
50Huntingtons disease_Homo sapiens_hsa050161.12208850
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09924929
52VEGF signaling pathway_Homo sapiens_hsa043701.05442779
53Biosynthesis of amino acids_Homo sapiens_hsa012301.03517250
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01661285
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01138313
56Arginine and proline metabolism_Homo sapiens_hsa003301.00533145
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98569487
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.93728818
59Phototransduction_Homo sapiens_hsa047440.93192506
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92396572
61Vibrio cholerae infection_Homo sapiens_hsa051100.87628508
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85155412
63Cardiac muscle contraction_Homo sapiens_hsa042600.83028729
64Arginine biosynthesis_Homo sapiens_hsa002200.81881764
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.80899374
66Wnt signaling pathway_Homo sapiens_hsa043100.80531725
67Type II diabetes mellitus_Homo sapiens_hsa049300.80329752
68Nitrogen metabolism_Homo sapiens_hsa009100.78507780
69Notch signaling pathway_Homo sapiens_hsa043300.78350555
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77491537
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77072984
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76858193
73Fatty acid elongation_Homo sapiens_hsa000620.76449526
74Hedgehog signaling pathway_Homo sapiens_hsa043400.76362256
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76201684
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75877135
77Choline metabolism in cancer_Homo sapiens_hsa052310.75860377
78* Rap1 signaling pathway_Homo sapiens_hsa040150.75157788
79AMPK signaling pathway_Homo sapiens_hsa041520.75149344
80MAPK signaling pathway_Homo sapiens_hsa040100.74915616
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.74538354
82Endometrial cancer_Homo sapiens_hsa052130.71620580
83Thyroid hormone synthesis_Homo sapiens_hsa049180.70931824
84Hippo signaling pathway_Homo sapiens_hsa043900.70798879
85Pancreatic secretion_Homo sapiens_hsa049720.70591949
86* Ras signaling pathway_Homo sapiens_hsa040140.70052208
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69527626
88Alcoholism_Homo sapiens_hsa050340.68879352
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68195459
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68166486
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67409565
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66974618
93Dorso-ventral axis formation_Homo sapiens_hsa043200.66821168
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66785007
95mRNA surveillance pathway_Homo sapiens_hsa030150.65807826
96Dilated cardiomyopathy_Homo sapiens_hsa054140.65593290
97mTOR signaling pathway_Homo sapiens_hsa041500.64398198
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63478740
99Tight junction_Homo sapiens_hsa045300.62869940
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62316138
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.61939362
102Glucagon signaling pathway_Homo sapiens_hsa049220.59972210
103Pyruvate metabolism_Homo sapiens_hsa006200.59950459
104Basal cell carcinoma_Homo sapiens_hsa052170.58418105
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57986870
106beta-Alanine metabolism_Homo sapiens_hsa004100.57896023
107Non-small cell lung cancer_Homo sapiens_hsa052230.57202370
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55257757
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55070921
110Prion diseases_Homo sapiens_hsa050200.52246479
111Carbon metabolism_Homo sapiens_hsa012000.51534357
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50827999
113Endocytosis_Homo sapiens_hsa041440.50535388
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49368375
115Bile secretion_Homo sapiens_hsa049760.49266929
116Fatty acid metabolism_Homo sapiens_hsa012120.49255367
117Renal cell carcinoma_Homo sapiens_hsa052110.48916110
118Bladder cancer_Homo sapiens_hsa052190.45428033
119Insulin signaling pathway_Homo sapiens_hsa049100.44628883
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44432567
121Colorectal cancer_Homo sapiens_hsa052100.43722189
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43164778
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.42319780
124Melanoma_Homo sapiens_hsa052180.41754480
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40954131
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40684499
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40590992
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39209439
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.38827556
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37843180
131Ovarian steroidogenesis_Homo sapiens_hsa049130.35417717
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32415620
133Proteoglycans in cancer_Homo sapiens_hsa052050.31429620
134Adherens junction_Homo sapiens_hsa045200.30212731

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