EFNA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)5.89695070
2mechanosensory behavior (GO:0007638)5.28717245
3startle response (GO:0001964)5.04731046
4negative regulation of dendrite morphogenesis (GO:0050774)4.52783191
5innervation (GO:0060384)4.27116786
6presynaptic membrane assembly (GO:0097105)4.17723433
7sympathetic nervous system development (GO:0048485)4.03253217
8response to pheromone (GO:0019236)3.95066492
9postsynaptic membrane organization (GO:0001941)3.94262453
10kidney morphogenesis (GO:0060993)3.87781280
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.82426902
12response to auditory stimulus (GO:0010996)3.76713214
13cochlea development (GO:0090102)3.56725483
14negative regulation of dendrite development (GO:2000171)3.56272259
15somite development (GO:0061053)3.53500031
16water-soluble vitamin biosynthetic process (GO:0042364)3.53195617
17ganglion development (GO:0061548)3.50956626
18presynaptic membrane organization (GO:0097090)3.47844497
19metanephric mesenchyme development (GO:0072075)3.47407723
20serotonin receptor signaling pathway (GO:0007210)3.35050478
21replication fork processing (GO:0031297)3.34388027
22cullin deneddylation (GO:0010388)3.33444143
23neuron cell-cell adhesion (GO:0007158)3.32490634
24neural crest cell development (GO:0014032)3.24559354
25kidney mesenchyme development (GO:0072074)3.23303204
26cornea development in camera-type eye (GO:0061303)3.22065424
27gonadal mesoderm development (GO:0007506)3.19262790
28DNA double-strand break processing (GO:0000729)3.19211198
29protein localization to cilium (GO:0061512)3.16080796
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.15180224
31regulation of secondary heart field cardioblast proliferation (GO:0003266)3.14081964
32regulation of cardioblast proliferation (GO:0003264)3.14081964
33embryonic skeletal joint morphogenesis (GO:0060272)3.12596105
34intraciliary transport (GO:0042073)3.12303716
35cellular response to prostaglandin stimulus (GO:0071379)3.11347055
36protein complex biogenesis (GO:0070271)3.09740716
37negative regulation of keratinocyte proliferation (GO:0010839)3.08664963
38* retinal ganglion cell axon guidance (GO:0031290)3.06662792
39nucleobase catabolic process (GO:0046113)3.05863118
40limb bud formation (GO:0060174)3.04962483
41negative regulation of axon guidance (GO:1902668)3.04733043
42mesenchymal cell differentiation involved in renal system development (GO:2001012)3.04515563
43mesenchymal cell differentiation involved in kidney development (GO:0072161)3.04515563
44reflex (GO:0060004)3.04109655
45protein deneddylation (GO:0000338)3.02262660
46mesenchymal cell differentiation (GO:0048762)3.01890230
47synapse assembly (GO:0007416)3.00836483
48cranial nerve development (GO:0021545)3.00825687
49behavioral response to nicotine (GO:0035095)3.00357348
50mesenchymal-epithelial cell signaling (GO:0060638)2.97284310
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95730051
52embryonic forelimb morphogenesis (GO:0035115)2.95514171
53cell migration in hindbrain (GO:0021535)2.94291834
54epithelial cilium movement (GO:0003351)2.93924778
55cell morphogenesis involved in neuron differentiation (GO:0048667)2.93514162
56regulation of male gonad development (GO:2000018)2.91802533
57respiratory chain complex IV assembly (GO:0008535)2.91053782
58proximal/distal pattern formation (GO:0009954)2.90911938
59urinary tract smooth muscle contraction (GO:0014848)2.85987024
60mesenchymal cell proliferation (GO:0010463)2.84516345
61cilium organization (GO:0044782)2.84075185
62mitochondrial respiratory chain complex assembly (GO:0033108)2.82297635
63protein polyglutamylation (GO:0018095)2.81458880
64cilium assembly (GO:0042384)2.81127536
65cell proliferation in forebrain (GO:0021846)2.80499321
66positive regulation of male gonad development (GO:2000020)2.80201337
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79957605
68forelimb morphogenesis (GO:0035136)2.79141590
69facial nerve structural organization (GO:0021612)2.78815197
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.78429420
71NADH dehydrogenase complex assembly (GO:0010257)2.78429420
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78429420
73regulation of hexokinase activity (GO:1903299)2.77690678
74regulation of glucokinase activity (GO:0033131)2.77690678
75outer ear morphogenesis (GO:0042473)2.76567909
76protein K6-linked ubiquitination (GO:0085020)2.75579460
77negative regulation of stem cell proliferation (GO:2000647)2.74007868
78platelet dense granule organization (GO:0060155)2.72889725
79regulation of mesoderm development (GO:2000380)2.72665248
80cranial nerve structural organization (GO:0021604)2.70827358
81protein neddylation (GO:0045116)2.70740503
82branch elongation of an epithelium (GO:0060602)2.69535112
83cytochrome complex assembly (GO:0017004)2.67953009
84resolution of meiotic recombination intermediates (GO:0000712)2.64792958
85regulation of pigment cell differentiation (GO:0050932)2.64354082
86neuron fate determination (GO:0048664)2.64102487
87protein localization to microtubule (GO:0035372)2.62739529
88negative regulation of chondrocyte differentiation (GO:0032331)2.62038860
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61976433
90cell differentiation involved in metanephros development (GO:0072202)2.61770554
91chondrocyte proliferation (GO:0035988)2.60855632
92embryonic digit morphogenesis (GO:0042733)2.60811880
93negative regulation of glycogen biosynthetic process (GO:0045719)2.60688973
94negative regulation of DNA-dependent DNA replication (GO:2000104)2.59620875
95mesenchymal cell development (GO:0014031)2.59272320
96photoreceptor cell maintenance (GO:0045494)2.58278839
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.57803598
98positive regulation of mitochondrial fission (GO:0090141)2.57348985
99limb development (GO:0060173)2.57344011
100appendage development (GO:0048736)2.57344011
101peripheral nervous system neuron development (GO:0048935)2.56061828
102negative regulation of myoblast differentiation (GO:0045662)2.55399052
103neurotransmitter-gated ion channel clustering (GO:0072578)2.54863016
104dorsal/ventral axis specification (GO:0009950)2.54477656
105branched-chain amino acid catabolic process (GO:0009083)2.54056896
106nonmotile primary cilium assembly (GO:0035058)2.53156658
107positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52843397
108regulation of cilium movement (GO:0003352)2.52492633
109regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52444533
110pyrimidine nucleobase catabolic process (GO:0006208)2.52292121
111positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51772851
112retina layer formation (GO:0010842)2.51526876
113dentate gyrus development (GO:0021542)2.51260621
114smoothened signaling pathway (GO:0007224)2.50341006
115nephron tubule morphogenesis (GO:0072078)2.50156360
116nephron epithelium morphogenesis (GO:0072088)2.50156360
117transmission of nerve impulse (GO:0019226)2.50025662
118cell differentiation involved in kidney development (GO:0061005)2.49840683
119axonal fasciculation (GO:0007413)2.49752644
120negative regulation of membrane potential (GO:0045837)2.48310216
121regulation of DNA endoreduplication (GO:0032875)2.48136652
122axoneme assembly (GO:0035082)2.47862992
123mesonephros development (GO:0001823)2.47287010
124positive regulation of synapse assembly (GO:0051965)2.47213774
125membrane assembly (GO:0071709)2.47193518
126pituitary gland development (GO:0021983)2.46595290
127lactate metabolic process (GO:0006089)2.46504685
128chromatin remodeling at centromere (GO:0031055)2.45449095
129negative regulation of activin receptor signaling pathway (GO:0032926)2.45182895
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45161315
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45011892
132vocalization behavior (GO:0071625)2.44975423
133preassembly of GPI anchor in ER membrane (GO:0016254)2.44888617
134inner ear receptor stereocilium organization (GO:0060122)2.44687892
135olfactory bulb development (GO:0021772)2.43391269
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.42724206
137regulation of translation, ncRNA-mediated (GO:0045974)2.42724206
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42724206
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.42630823
140nerve development (GO:0021675)2.42554067
141hindbrain development (GO:0030902)2.41936129
142spinal cord association neuron differentiation (GO:0021527)2.41908636
143regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.41614315
144negative regulation of DNA repair (GO:0045738)2.41392262
145neural tube formation (GO:0001841)2.41127193
146cilium morphogenesis (GO:0060271)2.41049732
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.40612247
148negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.39803035
149spinal cord development (GO:0021510)2.39482207
150peptidyl-cysteine modification (GO:0018198)2.38743024
151cilium movement (GO:0003341)2.38504329
152extracellular regulation of signal transduction (GO:1900115)2.38480090
153extracellular negative regulation of signal transduction (GO:1900116)2.38480090
154pancreas development (GO:0031016)2.38268772
155regulation of mesonephros development (GO:0061217)2.38247462
156recombinational repair (GO:0000725)2.37224348
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34879816
158double-strand break repair via homologous recombination (GO:0000724)2.34492577
159kinetochore assembly (GO:0051382)2.33775667
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33512462
161regulation of feeding behavior (GO:0060259)2.33127508
162striatum development (GO:0021756)2.32929960
163inositol phosphate catabolic process (GO:0071545)2.32246668
164fucose catabolic process (GO:0019317)2.30706100
165L-fucose metabolic process (GO:0042354)2.30706100
166L-fucose catabolic process (GO:0042355)2.30706100
167somite rostral/caudal axis specification (GO:0032525)2.29048832
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.27770829
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.27625513
170anterograde synaptic vesicle transport (GO:0048490)2.26545530
171dendritic spine morphogenesis (GO:0060997)2.26346265
172regulation of collateral sprouting (GO:0048670)2.26095855
173aldehyde catabolic process (GO:0046185)2.25134345
174regulation of mitotic spindle checkpoint (GO:1903504)2.23989169
175regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.23989169
176regulation of telomere maintenance (GO:0032204)2.23370394
177regulation of timing of cell differentiation (GO:0048505)2.23153738
178positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.22276489
179positive regulation of gastrulation (GO:2000543)2.21831703
180mannosylation (GO:0097502)2.21511684
181gamma-aminobutyric acid transport (GO:0015812)2.20652071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.09237300
2EZH2_22144423_ChIP-Seq_EOC_Human3.78056295
3ZNF274_21170338_ChIP-Seq_K562_Hela2.98314740
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81353177
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73264356
6TAF15_26573619_Chip-Seq_HEK293_Human2.71278625
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67101209
8* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.62277528
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.50663690
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.47601610
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46858488
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42456423
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40162440
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40015231
15RNF2_27304074_Chip-Seq_NSC_Mouse2.24260832
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.21842060
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20541755
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19101947
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18082168
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17647170
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17647170
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17447591
23FUS_26573619_Chip-Seq_HEK293_Human2.16623039
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15948222
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15727972
26* P300_19829295_ChIP-Seq_ESCs_Human2.13119766
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11537943
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07808499
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.02118560
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98379590
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95691446
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92986822
33* PIAS1_25552417_ChIP-Seq_VCAP_Human1.92394098
34* RNF2_27304074_Chip-Seq_ESCs_Mouse1.91585904
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90389860
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89173215
37SMAD4_21799915_ChIP-Seq_A2780_Human1.86126779
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.85007816
39* EWS_26573619_Chip-Seq_HEK293_Human1.78112995
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77428985
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.77110975
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75665349
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.66635623
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.65193095
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64868585
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63943573
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.61548913
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60509047
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59018327
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54471680
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54455983
52* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54110556
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53437699
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49013074
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48686642
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48289475
57IRF1_19129219_ChIP-ChIP_H3396_Human1.47538356
58* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47428452
59ELK1_19687146_ChIP-ChIP_HELA_Human1.42222097
60* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42186287
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41399680
62* EZH2_27294783_Chip-Seq_ESCs_Mouse1.38643851
63MYC_18940864_ChIP-ChIP_HL60_Human1.38251436
64* TP53_18474530_ChIP-ChIP_U2OS_Human1.38082040
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37374668
66CBP_20019798_ChIP-Seq_JUKART_Human1.36964480
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36964480
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36199019
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.34932388
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34920766
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33413519
72VDR_22108803_ChIP-Seq_LS180_Human1.33298081
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32479604
74* AR_25329375_ChIP-Seq_VCAP_Human1.31670616
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.29868910
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29735157
77* AHR_22903824_ChIP-Seq_MCF-7_Human1.28596547
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28546717
79* JUN_21703547_ChIP-Seq_K562_Human1.28501901
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28331002
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26903525
82* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26889908
83AR_21572438_ChIP-Seq_LNCaP_Human1.25603441
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.25515406
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25287744
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24865835
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.24691680
88* SOX9_26525672_Chip-Seq_HEART_Mouse1.24671315
89IGF1R_20145208_ChIP-Seq_DFB_Human1.23874866
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22465980
91* STAT3_23295773_ChIP-Seq_U87_Human1.22386594
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22133378
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20535018
94* TCF4_22108803_ChIP-Seq_LS180_Human1.20060782
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19775793
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.19681021
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19627718
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19478903
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16930252
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16709528
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16667804
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.16527435
103* NANOG_19829295_ChIP-Seq_ESCs_Human1.15780858
104* SOX2_19829295_ChIP-Seq_ESCs_Human1.15780858
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.15484118
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.13424702
107BCAT_22108803_ChIP-Seq_LS180_Human1.12718834
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11285857
109TP53_22573176_ChIP-Seq_HFKS_Human1.10926778
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10725694
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10412647
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09672116
113ER_23166858_ChIP-Seq_MCF-7_Human1.09459169
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09446151
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09408790
116* TCF4_23295773_ChIP-Seq_U87_Human1.08962583
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08450402
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07932680
119* REST_21632747_ChIP-Seq_MESCs_Mouse1.05617702
120P53_22387025_ChIP-Seq_ESCs_Mouse1.04939637
121* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04598362
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.04379739
123NANOG_16153702_ChIP-ChIP_HESCs_Human1.03735630
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.02973490
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02937955
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.01573377
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.01235508
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.01021651
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.00252007
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99517200
131* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99499294
132* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98599846
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96248180
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96248180
135HTT_18923047_ChIP-ChIP_STHdh_Human0.94570378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.30022819
2MP0000566_synostosis3.02580490
3MP0008789_abnormal_olfactory_epithelium3.02057202
4MP0002736_abnormal_nociception_after2.81655138
5MP0003121_genomic_imprinting2.74338159
6MP0001984_abnormal_olfaction2.72197001
7MP0005394_taste/olfaction_phenotype2.61780088
8MP0005499_abnormal_olfactory_system2.61780088
9MP0008877_abnormal_DNA_methylation2.42014270
10MP0001968_abnormal_touch/_nociception2.35318794
11MP0003787_abnormal_imprinting2.31124148
12MP0010030_abnormal_orbit_morphology2.23305208
13MP0003880_abnormal_central_pattern2.22592857
14MP0005248_abnormal_Harderian_gland2.18829199
15MP0000537_abnormal_urethra_morphology2.17332402
16MP0003941_abnormal_skin_development2.14111540
17MP0005503_abnormal_tendon_morphology2.11430176
18MP0003942_abnormal_urinary_system2.09224137
19MP0006072_abnormal_retinal_apoptosis2.05916106
20MP0002837_dystrophic_cardiac_calcinosis2.00616456
21MP0003195_calcinosis1.99699575
22MP0001188_hyperpigmentation1.97184162
23MP0009250_abnormal_appendicular_skeleto1.85809684
24MP0003385_abnormal_body_wall1.83711470
25MP0000778_abnormal_nervous_system1.81553565
26MP0006276_abnormal_autonomic_nervous1.75579524
27MP0002735_abnormal_chemical_nociception1.74445014
28MP0002249_abnormal_larynx_morphology1.69354639
29MP0000049_abnormal_middle_ear1.68994463
30MP0001346_abnormal_lacrimal_gland1.68846162
31MP0009697_abnormal_copulation1.67587850
32MP0002160_abnormal_reproductive_system1.65451302
33MP0004133_heterotaxia1.64865423
34MP0001485_abnormal_pinna_reflex1.64356405
35MP0001293_anophthalmia1.64046888
36MP0002751_abnormal_autonomic_nervous1.62254105
37MP0005253_abnormal_eye_physiology1.62011253
38MP0000516_abnormal_urinary_system1.60571214
39MP0005367_renal/urinary_system_phenotyp1.60571214
40MP0005551_abnormal_eye_electrophysiolog1.59970171
41MP0002638_abnormal_pupillary_reflex1.53602918
42MP0005646_abnormal_pituitary_gland1.51640772
43MP0002734_abnormal_mechanical_nocicepti1.45715868
44* MP0003755_abnormal_palate_morphology1.44348353
45* MP0002184_abnormal_innervation1.43451986
46MP0003136_yellow_coat_color1.43451031
47MP0009053_abnormal_anal_canal1.41498074
48MP0002876_abnormal_thyroid_physiology1.41468516
49MP0003123_paternal_imprinting1.41054983
50MP0000372_irregular_coat_pigmentation1.41054447
51MP0001486_abnormal_startle_reflex1.38530750
52MP0002938_white_spotting1.37407636
53MP0000631_abnormal_neuroendocrine_gland1.35426153
54MP0002234_abnormal_pharynx_morphology1.34549651
55MP0004270_analgesia1.32229483
56MP0005645_abnormal_hypothalamus_physiol1.31126415
57MP0002233_abnormal_nose_morphology1.30956930
58MP0005171_absent_coat_pigmentation1.30210651
59MP0003635_abnormal_synaptic_transmissio1.28130285
60MP0002063_abnormal_learning/memory/cond1.27399254
61MP0000538_abnormal_urinary_bladder1.27135690
62MP0003937_abnormal_limbs/digits/tail_de1.25985415
63MP0004859_abnormal_synaptic_plasticity1.24523199
64MP0008058_abnormal_DNA_repair1.23854345
65MP0000647_abnormal_sebaceous_gland1.23764164
66MP0010234_abnormal_vibrissa_follicle1.22268536
67MP0000534_abnormal_ureter_morphology1.21956511
68MP0001177_atelectasis1.21457448
69MP0003283_abnormal_digestive_organ1.21394109
70MP0000026_abnormal_inner_ear1.21094474
71MP0002572_abnormal_emotion/affect_behav1.20412926
72MP0002102_abnormal_ear_morphology1.20134844
73MP0003890_abnormal_embryonic-extraembry1.19059839
74MP0002653_abnormal_ependyma_morphology1.18083260
75MP0001905_abnormal_dopamine_level1.16837894
76MP0004272_abnormal_basement_membrane1.16268358
77MP0006292_abnormal_olfactory_placode1.15637864
78MP0002557_abnormal_social/conspecific_i1.15613933
79MP0002177_abnormal_outer_ear1.14572413
80MP0003938_abnormal_ear_development1.14213848
81MP0000569_abnormal_digit_pigmentation1.13153253
82MP0002282_abnormal_trachea_morphology1.12946368
83MP0009046_muscle_twitch1.12921555
84MP0003315_abnormal_perineum_morphology1.11451218
85MP0004858_abnormal_nervous_system1.09307453
86MP0002067_abnormal_sensory_capabilities1.09277987
87MP0002116_abnormal_craniofacial_bone1.08975345
88MP0000015_abnormal_ear_pigmentation1.08912087
89MP0005275_abnormal_skin_tensile1.06720282
90MP0009745_abnormal_behavioral_response1.04093344
91MP0001286_abnormal_eye_development1.03709632
92MP0004885_abnormal_endolymph1.03640303
93MP0005195_abnormal_posterior_eye1.02201955
94MP0008995_early_reproductive_senescence1.00973157
95MP0005389_reproductive_system_phenotype1.00839772
96MP0003011_delayed_dark_adaptation1.00660588
97MP0006054_spinal_hemorrhage0.98657549
98MP0005391_vision/eye_phenotype0.98109433
99MP0003115_abnormal_respiratory_system0.96475773
100MP0004142_abnormal_muscle_tone0.95761963
101MP0002928_abnormal_bile_duct0.95453324
102MP0001529_abnormal_vocalization0.95224905
103MP0005379_endocrine/exocrine_gland_phen0.94547733
104MP0001919_abnormal_reproductive_system0.94408231
105MP0002163_abnormal_gland_morphology0.93115803
106MP0002090_abnormal_vision0.92967756
107MP0001299_abnormal_eye_distance/0.92482736
108MP0005508_abnormal_skeleton_morphology0.92199324
109MP0001970_abnormal_pain_threshold0.91824828
110MP0002909_abnormal_adrenal_gland0.91636808
111MP0004215_abnormal_myocardial_fiber0.90236299
112MP0008872_abnormal_physiological_respon0.90092299
113MP0005386_behavior/neurological_phenoty0.89920347
114MP0004924_abnormal_behavior0.89920347
115MP0001502_abnormal_circadian_rhythm0.89619398
116MP0005257_abnormal_intraocular_pressure0.89392608
117MP0002109_abnormal_limb_morphology0.86893480
118MP0002272_abnormal_nervous_system0.86355851
119MP0003718_maternal_effect0.86275273
120MP0002733_abnormal_thermal_nociception0.85755465
121MP0000955_abnormal_spinal_cord0.85379753
122MP0003119_abnormal_digestive_system0.85300273
123MP0005187_abnormal_penis_morphology0.83667905
124MP0003137_abnormal_impulse_conducting0.83602461
125MP0000427_abnormal_hair_cycle0.82860382
126* MP0003861_abnormal_nervous_system0.82488453
127* MP0002752_abnormal_somatic_nervous0.82406640
128MP0002009_preneoplasia0.81542864
129MP0003567_abnormal_fetal_cardiomyocyte0.81339083
130MP0002697_abnormal_eye_size0.80869233
131MP0001963_abnormal_hearing_physiology0.80174623
132MP0005084_abnormal_gallbladder_morpholo0.79941291
133MP0002064_seizures0.79936891
134MP0004085_abnormal_heartbeat0.77614522
135MP0004484_altered_response_of0.76294107
136MP0009379_abnormal_foot_pigmentation0.76146849
137MP0010094_abnormal_chromosome_stability0.76053331
138MP0000762_abnormal_tongue_morphology0.76018662
139* MP0002882_abnormal_neuron_morphology0.75644501
140MP0000653_abnormal_sex_gland0.75384790
141MP0003935_abnormal_craniofacial_develop0.75155239
142MP0002210_abnormal_sex_determination0.74560419

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.95738559
2Morphological abnormality of the middle ear (HP:0008609)3.40032576
3Abnormality of midbrain morphology (HP:0002418)3.30854787
4Molar tooth sign on MRI (HP:0002419)3.30854787
5Abnormal hair whorl (HP:0010721)3.23306396
6Absent eyebrow (HP:0002223)3.23232194
7Gait imbalance (HP:0002141)3.20856965
8Vaginal atresia (HP:0000148)3.20135972
9Congenital primary aphakia (HP:0007707)3.18364330
10Genital tract atresia (HP:0001827)3.18158669
11Nephrogenic diabetes insipidus (HP:0009806)3.12109471
12Febrile seizures (HP:0002373)3.06061493
13Medial flaring of the eyebrow (HP:0010747)2.95238325
14Submucous cleft hard palate (HP:0000176)2.93069766
15Aplasia/Hypoplasia of the tibia (HP:0005772)2.91772402
16True hermaphroditism (HP:0010459)2.89956405
17Embryonal renal neoplasm (HP:0011794)2.85968242
18Nephroblastoma (Wilms tumor) (HP:0002667)2.83564760
19Adrenal hypoplasia (HP:0000835)2.81079300
20Poor coordination (HP:0002370)2.80560066
21Intestinal atresia (HP:0011100)2.79996341
22Absent eyelashes (HP:0000561)2.78769564
23Abnormality of the nasolacrimal system (HP:0000614)2.76432983
24Short tibia (HP:0005736)2.73466013
25Abnormality of the renal medulla (HP:0100957)2.69171235
26Atonic seizures (HP:0010819)2.66485302
27Abnormality of the lacrimal duct (HP:0011481)2.64854941
28Occipital encephalocele (HP:0002085)2.64316889
29Hepatoblastoma (HP:0002884)2.62515663
30Cutaneous finger syndactyly (HP:0010554)2.58038235
31Aqueductal stenosis (HP:0002410)2.56799107
32Pancreatic fibrosis (HP:0100732)2.53788581
33Bifid tongue (HP:0010297)2.50617375
34Methylmalonic acidemia (HP:0002912)2.46996205
35Dental crowding (HP:0000678)2.34050838
36Abnormal lung lobation (HP:0002101)2.29572314
37Stenosis of the external auditory canal (HP:0000402)2.28666719
38Colon cancer (HP:0003003)2.27834158
39Oligodactyly (hands) (HP:0001180)2.26959478
40Cystic liver disease (HP:0006706)2.26726686
41Supernumerary spleens (HP:0009799)2.26031685
42Abnormality of the labia minora (HP:0012880)2.25847046
43Abnormality of the aortic arch (HP:0012303)2.24423274
44Focal motor seizures (HP:0011153)2.23961369
45Aplasia/Hypoplasia of the lens (HP:0008063)2.21007028
46Abnormality of the phalanges of the hallux (HP:0010057)2.19353812
47Postaxial foot polydactyly (HP:0001830)2.18733748
48Severe Myopia (HP:0011003)2.18443948
49Abnormality of the nasal septum (HP:0000419)2.18177466
50Sclerocornea (HP:0000647)2.17757801
51Abnormality of incisor morphology (HP:0011063)2.17367277
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.15843416
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14467358
54Optic nerve hypoplasia (HP:0000609)2.13470567
55Cutaneous syndactyly (HP:0012725)2.11942093
56Renal hypoplasia (HP:0000089)2.08272093
57Wrist flexion contracture (HP:0001239)2.07848664
58Median cleft lip (HP:0000161)2.07195996
59Hyperglycinemia (HP:0002154)2.06923029
60Asymmetry of the thorax (HP:0001555)2.06264311
61Abnormality of the fetal cardiovascular system (HP:0010948)2.05875788
62Abnormal umbilical cord blood vessels (HP:0011403)2.05875788
63Single umbilical artery (HP:0001195)2.05875788
64Tubular atrophy (HP:0000092)2.05205531
65Abnormality of the renal cortex (HP:0011035)2.05049229
66Pancreatic cysts (HP:0001737)2.04841686
67Septo-optic dysplasia (HP:0100842)2.02627756
68Natal tooth (HP:0000695)2.01445054
69Pendular nystagmus (HP:0012043)1.98272680
70Neoplasm of the adrenal cortex (HP:0100641)1.98249217
71Midline defect of the nose (HP:0004122)1.97612662
72Periauricular skin pits (HP:0100277)1.97123419
73Preauricular pit (HP:0004467)1.97123419
74Acute encephalopathy (HP:0006846)1.97072921
75Papillary thyroid carcinoma (HP:0002895)1.96109913
76Scrotal hypoplasia (HP:0000046)1.96069700
77Myelomeningocele (HP:0002475)1.94926794
78Gastroesophageal reflux (HP:0002020)1.94565178
79Diastasis recti (HP:0001540)1.94492590
80Gastrointestinal atresia (HP:0002589)1.92620551
81Impaired pain sensation (HP:0007328)1.89819489
82Abnormality of pain sensation (HP:0010832)1.89819489
83Hyperventilation (HP:0002883)1.89528079
84Congenital stationary night blindness (HP:0007642)1.89335784
85Thyroid carcinoma (HP:0002890)1.89189218
86Progressive macrocephaly (HP:0004481)1.88243204
87Chorioretinal coloboma (HP:0000567)1.88022965
88Anophthalmia (HP:0000528)1.87721008
89Anencephaly (HP:0002323)1.87535925
90Male pseudohermaphroditism (HP:0000037)1.86617806
91Methylmalonic aciduria (HP:0012120)1.86469653
92Tubulointerstitial nephritis (HP:0001970)1.85684679
93Germ cell neoplasia (HP:0100728)1.84749821
94Curly hair (HP:0002212)1.84444788
95Mitochondrial inheritance (HP:0001427)1.84282126
96Bradycardia (HP:0001662)1.83790553
97Abnormality of chromosome stability (HP:0003220)1.83510170
98Preaxial hand polydactyly (HP:0001177)1.82773816
99Dandy-Walker malformation (HP:0001305)1.82565912
100Abnormal biliary tract physiology (HP:0012439)1.82186558
101Bile duct proliferation (HP:0001408)1.82186558
102Abolished electroretinogram (ERG) (HP:0000550)1.82103224
103Broad foot (HP:0001769)1.81705522
104Narrow forehead (HP:0000341)1.81566511
105Narrow nasal bridge (HP:0000446)1.81295596
106Nasal speech (HP:0001611)1.81075116
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.80610675
108Increased CSF lactate (HP:0002490)1.80561823
109Synostosis involving the elbow (HP:0003938)1.80355706
110Humeroradial synostosis (HP:0003041)1.80355706
111Increased hepatocellular lipid droplets (HP:0006565)1.80309503
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.79388884
113Labial hypoplasia (HP:0000066)1.79058060
114Disproportionate short-trunk short stature (HP:0003521)1.77828957
115Epileptic encephalopathy (HP:0200134)1.77609146
116Hyperinsulinemic hypoglycemia (HP:0000825)1.77416458
117Acute necrotizing encephalopathy (HP:0006965)1.77027222
118Triphalangeal thumb (HP:0001199)1.76994914
119Congenital hepatic fibrosis (HP:0002612)1.76968078
120Meckel diverticulum (HP:0002245)1.76901456
121Multicystic kidney dysplasia (HP:0000003)1.74905207
122Chronic hepatic failure (HP:0100626)1.74748268
123Ectopic kidney (HP:0000086)1.74553320
124Short foot (HP:0001773)1.74261371
125Bilateral microphthalmos (HP:0007633)1.73033285
126Alveolar cell carcinoma (HP:0006519)1.71611995
127Hemiparesis (HP:0001269)1.71075964
128Renal dysplasia (HP:0000110)1.70085680
129Nasolacrimal duct obstruction (HP:0000579)1.69886336
130Postaxial hand polydactyly (HP:0001162)1.68979916
131Abnormality of the proximal phalanges of the hand (HP:0009834)1.68865264
132Abnormal mitochondria in muscle tissue (HP:0008316)1.67553156
133Abnormality of the ileum (HP:0001549)1.67408040
134Abnormal pancreas size (HP:0012094)1.67157255
135Microglossia (HP:0000171)1.66810442
136Furrowed tongue (HP:0000221)1.66794725
137Tracheomalacia (HP:0002779)1.65999049
138Small hand (HP:0200055)1.65938102
139Volvulus (HP:0002580)1.65311562
140Specific learning disability (HP:0001328)1.65079607
141Decreased testicular size (HP:0008734)1.65017336
142Aplasia/hypoplasia of the uterus (HP:0008684)1.64708740
143Astigmatism (HP:0000483)1.63796667
144Hypoplastic female external genitalia (HP:0012815)1.63380323
145Absent hair (HP:0002298)1.63292845
146Broad-based gait (HP:0002136)1.62746646
147Oligodactyly (HP:0012165)1.62404417
148Breast carcinoma (HP:0003002)1.61322319
149Lipid accumulation in hepatocytes (HP:0006561)1.61280429
150Aganglionic megacolon (HP:0002251)1.60823004
151Hypoglycemic seizures (HP:0002173)1.60786889
152Abnormality of dentin (HP:0010299)1.59620375
153Absent thumb (HP:0009777)1.59473742
154Aplasia/Hypoplasia of the hallux (HP:0008362)1.59424196
155Polydipsia (HP:0001959)1.58564336
156Abnormal drinking behavior (HP:0030082)1.58564336
157Embryonal neoplasm (HP:0002898)1.56982628
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56119447
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56118784
160Short 1st metacarpal (HP:0010034)1.56118784
161Downturned corners of mouth (HP:0002714)1.55551396
162Nephronophthisis (HP:0000090)1.55521792
163Asthma (HP:0002099)1.55325342
164Aplasia cutis congenita (HP:0001057)1.54537927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.69672062
2AKT33.60733884
3WNK33.54554655
4STK38L3.46998492
5TRIM283.36197624
6MAP4K22.78209079
7MAP2K72.67695032
8SGK22.50236325
9ERBB32.44441206
10FRK2.37379246
11NTRK22.32862537
12MAPK132.24914745
13PLK22.24314831
14PRPF4B2.15539119
15FER2.11497633
16MAP3K122.09599227
17SIK32.07323089
18ACVR1B2.04691632
19GRK11.98024142
20NEK11.88434516
21BCR1.83463304
22SGK4941.82674598
23SGK2231.82674598
24STK241.73013433
25ZAK1.72483496
26YES11.63835684
27MKNK21.61307547
28SRPK11.58836282
29BMPR21.53810483
30MAP3K41.49638178
31SGK31.43423738
32PINK11.37382887
33EPHB21.32768201
34BRAF1.32109213
35MINK11.32106855
36MKNK11.29789146
37DAPK21.22835696
38STK391.18127657
39TAOK21.16025567
40INSRR1.12477838
41NTRK31.07971230
42TNIK1.07825182
43CSNK1G31.06758571
44BRSK21.06265426
45VRK21.04728265
46EPHA41.04516102
47EIF2AK31.03038149
48DYRK31.02576110
49PNCK0.99697913
50MST40.97744362
51MAP2K40.97728542
52TGFBR10.95696355
53WEE10.95055747
54WNK40.91979289
55BUB10.91030930
56CCNB10.90492888
57DYRK20.90251020
58CSNK1G20.90188314
59PLK30.89183163
60CSNK1A1L0.88971178
61MARK10.88612475
62BMPR1B0.87315628
63OXSR10.87090446
64RPS6KA20.83627214
65TAF10.82698542
66VRK10.81659675
67PLK10.78165449
68PRKCG0.77755799
69LIMK10.76277289
70ADRBK20.75826852
71STK160.75492961
72CSNK1G10.75365676
73GRK70.74720084
74PRKCE0.73500139
75ADRBK10.72818087
76PHKG20.72692436
77PHKG10.72692436
78CDK30.69170443
79MYLK0.68409195
80EIF2AK20.66502075
81CDC70.66423989
82PIK3CA0.65297822
83CDK80.64736011
84RPS6KB10.63793721
85TSSK60.62310797
86NEK60.61280035
87CAMK2A0.61125642
88BCKDK0.59826585
89NLK0.59559518
90STK30.58784154
91ROCK10.58612354
92DAPK10.57719788
93PASK0.57311903
94TTK0.56450364
95CAMK40.55515241
96RPS6KL10.55192204
97RPS6KC10.55192204
98ATR0.52358360
99FGFR20.52145780
100LATS20.51200911
101CDK190.49631271
102PAK30.48420153
103PRKCH0.47299030
104ATM0.47064243
105EIF2AK10.46943688
106RPS6KA60.43405887
107GRK50.40388883
108CAMK2B0.40099798
109DYRK1A0.39473205
110TIE10.39251217
111CAMK10.38432512
112ROCK20.37522381
113NUAK10.37102490
114MAP2K10.35807183
115CHEK20.35701236
116ERBB40.35488677
117PTK2B0.35394932
118CAMKK20.35215804
119PLK40.33129160
120CDK50.32931739
121CDC42BPA0.32563709
122RPS6KA40.32530654
123STK110.32398168
124TNK20.32267837
125PKN10.31590200
126SGK10.31298535
127CHUK0.31227075
128STK380.30790833
129AURKA0.29978052
130CSNK1E0.29095891
131CSNK1D0.28740434
132EPHA30.27823459
133PRKACA0.27192185
134CAMK2D0.25047111
135CDK180.25018510
136CSNK1A10.24582354
137PRKD30.24486818
138FGFR10.24238816
139PRKG10.22659070
140LATS10.21982291
141PRKCI0.21631146
142CAMK2G0.20579885
143UHMK10.20570417

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94395107
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75445347
3Olfactory transduction_Homo sapiens_hsa047402.74510463
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.70504487
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.49562785
6Collecting duct acid secretion_Homo sapiens_hsa049662.41064483
7Propanoate metabolism_Homo sapiens_hsa006402.39859909
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36027242
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25066368
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08495320
11Homologous recombination_Homo sapiens_hsa034402.07529928
12Butanoate metabolism_Homo sapiens_hsa006502.03525089
13Circadian entrainment_Homo sapiens_hsa047131.95031263
14Vibrio cholerae infection_Homo sapiens_hsa051101.94498208
15Basal cell carcinoma_Homo sapiens_hsa052171.92605320
16Taste transduction_Homo sapiens_hsa047421.83479852
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78572152
18Serotonergic synapse_Homo sapiens_hsa047261.76925961
19Amphetamine addiction_Homo sapiens_hsa050311.74134695
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74131249
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73385378
22Oxidative phosphorylation_Homo sapiens_hsa001901.69543460
23Nitrogen metabolism_Homo sapiens_hsa009101.66682014
24* Axon guidance_Homo sapiens_hsa043601.61602763
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.59678080
26Hedgehog signaling pathway_Homo sapiens_hsa043401.59672758
27Steroid biosynthesis_Homo sapiens_hsa001001.59281321
28Endometrial cancer_Homo sapiens_hsa052131.59256026
29Dopaminergic synapse_Homo sapiens_hsa047281.58698919
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53513924
31Hippo signaling pathway_Homo sapiens_hsa043901.51798537
32Thyroid cancer_Homo sapiens_hsa052161.50966576
33Phototransduction_Homo sapiens_hsa047441.48723706
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46509027
35Melanogenesis_Homo sapiens_hsa049161.46461930
36Morphine addiction_Homo sapiens_hsa050321.43147016
37TGF-beta signaling pathway_Homo sapiens_hsa043501.40338065
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39773524
39RNA polymerase_Homo sapiens_hsa030201.39212802
40Long-term potentiation_Homo sapiens_hsa047201.35666574
41Melanoma_Homo sapiens_hsa052181.35664001
42Selenocompound metabolism_Homo sapiens_hsa004501.32054466
43Wnt signaling pathway_Homo sapiens_hsa043101.31914139
44Renin secretion_Homo sapiens_hsa049241.28670835
45Tryptophan metabolism_Homo sapiens_hsa003801.28163683
46Vitamin B6 metabolism_Homo sapiens_hsa007501.27657539
47GABAergic synapse_Homo sapiens_hsa047271.26486818
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25020243
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21804458
50Mismatch repair_Homo sapiens_hsa034301.21741916
51Insulin secretion_Homo sapiens_hsa049111.20784415
52Glutamatergic synapse_Homo sapiens_hsa047241.18935943
53Fanconi anemia pathway_Homo sapiens_hsa034601.18865242
54Huntingtons disease_Homo sapiens_hsa050161.14538649
55Parkinsons disease_Homo sapiens_hsa050121.13025843
56Peroxisome_Homo sapiens_hsa041461.12831980
57Cholinergic synapse_Homo sapiens_hsa047251.11871339
58Gap junction_Homo sapiens_hsa045401.10511600
59Alzheimers disease_Homo sapiens_hsa050101.08782248
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08658600
61Adherens junction_Homo sapiens_hsa045201.06324985
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06113828
63Dilated cardiomyopathy_Homo sapiens_hsa054141.00919798
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.00754344
65Oocyte meiosis_Homo sapiens_hsa041141.00369661
66Long-term depression_Homo sapiens_hsa047301.00226081
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99921823
68Cocaine addiction_Homo sapiens_hsa050300.99057638
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98411955
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96547548
71Prostate cancer_Homo sapiens_hsa052150.96510439
72ErbB signaling pathway_Homo sapiens_hsa040120.95831424
73Ether lipid metabolism_Homo sapiens_hsa005650.93220484
74Linoleic acid metabolism_Homo sapiens_hsa005910.92245286
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91146282
76Basal transcription factors_Homo sapiens_hsa030220.91106365
77Calcium signaling pathway_Homo sapiens_hsa040200.90980597
78beta-Alanine metabolism_Homo sapiens_hsa004100.90406803
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90403921
80Proteasome_Homo sapiens_hsa030500.90391625
81Regulation of autophagy_Homo sapiens_hsa041400.89629838
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89083706
83Phagosome_Homo sapiens_hsa041450.86863949
84Colorectal cancer_Homo sapiens_hsa052100.86729823
85Folate biosynthesis_Homo sapiens_hsa007900.86428422
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.85972659
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85915625
88Pyruvate metabolism_Homo sapiens_hsa006200.85416098
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84474695
90Caffeine metabolism_Homo sapiens_hsa002320.84469852
91Cell cycle_Homo sapiens_hsa041100.84408778
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82603491
93Phenylalanine metabolism_Homo sapiens_hsa003600.81997215
94Arachidonic acid metabolism_Homo sapiens_hsa005900.81511312
95Fatty acid metabolism_Homo sapiens_hsa012120.79859750
96cAMP signaling pathway_Homo sapiens_hsa040240.77332276
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76673710
98Retinol metabolism_Homo sapiens_hsa008300.75900495
99RNA transport_Homo sapiens_hsa030130.75222450
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75145737
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73288213
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72386107
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72235691
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71384394
105Protein export_Homo sapiens_hsa030600.69917298
106Nucleotide excision repair_Homo sapiens_hsa034200.69453469
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68565483
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68446422
109Purine metabolism_Homo sapiens_hsa002300.67981844
110Metabolic pathways_Homo sapiens_hsa011000.67812444
111Sulfur metabolism_Homo sapiens_hsa009200.66809024
112Cardiac muscle contraction_Homo sapiens_hsa042600.66234189
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64577666
114Glutathione metabolism_Homo sapiens_hsa004800.64222202
115Rheumatoid arthritis_Homo sapiens_hsa053230.63518314
116Tyrosine metabolism_Homo sapiens_hsa003500.62778039
117Tight junction_Homo sapiens_hsa045300.60839000
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60025709
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59609308
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59017895
121p53 signaling pathway_Homo sapiens_hsa041150.58467594
122Chemical carcinogenesis_Homo sapiens_hsa052040.57633070
123Oxytocin signaling pathway_Homo sapiens_hsa049210.57468731
124GnRH signaling pathway_Homo sapiens_hsa049120.57220309
125Fatty acid degradation_Homo sapiens_hsa000710.56197757
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53356857
127* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53001156
128One carbon pool by folate_Homo sapiens_hsa006700.52296711
129MicroRNAs in cancer_Homo sapiens_hsa052060.51727411
130RNA degradation_Homo sapiens_hsa030180.51078338
131Pathways in cancer_Homo sapiens_hsa052000.50927236
132Fatty acid elongation_Homo sapiens_hsa000620.50883754
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50623811
134Pyrimidine metabolism_Homo sapiens_hsa002400.50449008
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49899942
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.49500893
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.48699040
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48477844
139Salivary secretion_Homo sapiens_hsa049700.47937256
140MAPK signaling pathway_Homo sapiens_hsa040100.47684973
141Base excision repair_Homo sapiens_hsa034100.47028858
142Alcoholism_Homo sapiens_hsa050340.45673483
143Lysine degradation_Homo sapiens_hsa003100.45434294
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45215877
145* Ras signaling pathway_Homo sapiens_hsa040140.42467215
146* Rap1 signaling pathway_Homo sapiens_hsa040150.41115229
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37737481
148ECM-receptor interaction_Homo sapiens_hsa045120.36247086
149N-Glycan biosynthesis_Homo sapiens_hsa005100.35437130
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35093396
151Circadian rhythm_Homo sapiens_hsa047100.33854198
152Ovarian steroidogenesis_Homo sapiens_hsa049130.33507785
153Glioma_Homo sapiens_hsa052140.33106884
154FoxO signaling pathway_Homo sapiens_hsa040680.32519950
155Focal adhesion_Homo sapiens_hsa045100.31787347
156Non-homologous end-joining_Homo sapiens_hsa034500.31042303

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