EFS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.11123668
2planar cell polarity pathway involved in neural tube closure (GO:0090179)5.07340874
3paraxial mesoderm development (GO:0048339)4.83978356
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.77326778
5desmosome organization (GO:0002934)4.52979299
6postsynaptic membrane organization (GO:0001941)4.37536439
7outer ear morphogenesis (GO:0042473)4.33426430
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.13792597
9central nervous system myelination (GO:0022010)4.12959300
10axon ensheathment in central nervous system (GO:0032291)4.12959300
11hemidesmosome assembly (GO:0031581)4.10257011
12axonal fasciculation (GO:0007413)4.03180726
13presynaptic membrane organization (GO:0097090)3.98811551
14establishment of planar polarity (GO:0001736)3.84772388
15establishment of tissue polarity (GO:0007164)3.84772388
16presynaptic membrane assembly (GO:0097105)3.84405927
17pyrimidine nucleobase catabolic process (GO:0006208)3.80825646
18establishment of apical/basal cell polarity (GO:0035089)3.75418187
19neuron recognition (GO:0008038)3.73958213
20collecting duct development (GO:0072044)3.71099277
21non-canonical Wnt signaling pathway (GO:0035567)3.70574732
22cochlea morphogenesis (GO:0090103)3.70403755
23lung-associated mesenchyme development (GO:0060484)3.69861211
24epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.69379964
25mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.59776524
26lung epithelium development (GO:0060428)3.56870777
27dendritic spine morphogenesis (GO:0060997)3.56284600
28mesenchyme morphogenesis (GO:0072132)3.51901756
29endocardial cushion morphogenesis (GO:0003203)3.49205112
30camera-type eye morphogenesis (GO:0048593)3.48082322
31Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.46154301
32negative regulation of chondrocyte differentiation (GO:0032331)3.45925065
33digestive tract morphogenesis (GO:0048546)3.44655687
34spinal cord development (GO:0021510)3.44597768
35notochord development (GO:0030903)3.44009510
36cell migration in hindbrain (GO:0021535)3.37577572
37regulation of establishment of planar polarity (GO:0090175)3.34892963
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.33252717
39axon extension involved in axon guidance (GO:0048846)3.33252717
40locomotory exploration behavior (GO:0035641)3.30622837
41polarized epithelial cell differentiation (GO:0030859)3.29754646
42cell proliferation in forebrain (GO:0021846)3.28716640
43mesenchymal cell proliferation (GO:0010463)3.28127469
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.28088333
45substrate-independent telencephalic tangential migration (GO:0021826)3.28088333
46pattern specification involved in kidney development (GO:0061004)3.26915542
47cell surface receptor signaling pathway involved in heart development (GO:0061311)3.23521917
48regulation of posttranscriptional gene silencing (GO:0060147)3.21295120
49regulation of gene silencing by miRNA (GO:0060964)3.21295120
50regulation of gene silencing by RNA (GO:0060966)3.21295120
51establishment of monopolar cell polarity (GO:0061162)3.20608090
52establishment or maintenance of monopolar cell polarity (GO:0061339)3.20608090
53regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.16374208
54mesenchymal to epithelial transition (GO:0060231)3.15145078
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.13632207
56hindlimb morphogenesis (GO:0035137)3.11615130
57neuronal ion channel clustering (GO:0045161)3.10913281
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10754196
59negative regulation of cartilage development (GO:0061037)3.04032836
60eyelid development in camera-type eye (GO:0061029)3.00601743
61limb bud formation (GO:0060174)3.00016885
62embryonic hindlimb morphogenesis (GO:0035116)2.99263022
63neuron cell-cell adhesion (GO:0007158)2.98233691
64regulation of hippo signaling (GO:0035330)2.97063070
65negative regulation of oligodendrocyte differentiation (GO:0048715)2.96545468
66cerebral cortex radially oriented cell migration (GO:0021799)2.94891311
67proximal/distal pattern formation (GO:0009954)2.94734677
68lens fiber cell development (GO:0070307)2.93230901
69protein heterotrimerization (GO:0070208)2.91320368
70epithelial cell fate commitment (GO:0072148)2.88709959
71vocalization behavior (GO:0071625)2.87496816
72nucleobase catabolic process (GO:0046113)2.86908823
73embryonic cranial skeleton morphogenesis (GO:0048701)2.86801526
74lung morphogenesis (GO:0060425)2.86771501
75bone trabecula formation (GO:0060346)2.86042456
76heart valve formation (GO:0003188)2.85721832
77tongue development (GO:0043586)2.85679135
78apical protein localization (GO:0045176)2.85605635
79positive regulation of neuroblast proliferation (GO:0002052)2.85603535
80regulation of heart morphogenesis (GO:2000826)2.85080393
81hippo signaling (GO:0035329)2.84672240
82positive regulation of synapse assembly (GO:0051965)2.84013011
83ganglion development (GO:0061548)2.83965098
84anatomical structure regression (GO:0060033)2.83369042
85branching involved in salivary gland morphogenesis (GO:0060445)2.83239134
86negative regulation of embryonic development (GO:0045992)2.82861022
87negative regulation of catenin import into nucleus (GO:0035414)2.82617650
88mesenchyme development (GO:0060485)2.82090708
89embryonic camera-type eye development (GO:0031076)2.81442732
90convergent extension (GO:0060026)2.80495864
91cell proliferation involved in metanephros development (GO:0072203)2.79306659
92myelination in peripheral nervous system (GO:0022011)2.78333064
93peripheral nervous system axon ensheathment (GO:0032292)2.78333064
94regulation of somitogenesis (GO:0014807)2.76334551
95face development (GO:0060324)2.76093690
96negative regulation of cell fate specification (GO:0009996)2.75767151
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.72079073
98exploration behavior (GO:0035640)2.72076926
99regulation of water loss via skin (GO:0033561)2.70848239
100axon extension (GO:0048675)2.70833223
101renal system development (GO:0072001)2.69656361
102embryonic skeletal joint morphogenesis (GO:0060272)2.69591501
103somatic stem cell division (GO:0048103)2.69548304
104central nervous system projection neuron axonogenesis (GO:0021952)2.69335937
105forebrain neuron differentiation (GO:0021879)2.68153659
106positive regulation of gastrulation (GO:2000543)2.68068094
107protein localization to synapse (GO:0035418)2.67817206
108regulation of mesenchymal cell apoptotic process (GO:2001053)2.67569542
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.67252393
110limb development (GO:0060173)2.66295366
111appendage development (GO:0048736)2.66295366
112astrocyte differentiation (GO:0048708)2.66032160
113neuronal stem cell maintenance (GO:0097150)2.65793379
114hair cycle (GO:0042633)2.65345818
115molting cycle (GO:0042303)2.65345818
116glomerular basement membrane development (GO:0032836)2.64399006
117middle ear morphogenesis (GO:0042474)2.64279546
118cell-cell junction maintenance (GO:0045217)2.64274744
119respiratory tube development (GO:0030323)2.64136425
120establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63706921
121negative regulation of smoothened signaling pathway (GO:0045879)2.63142111
122negative regulation of axon guidance (GO:1902668)2.62941379
123establishment of skin barrier (GO:0061436)2.62853421
124retinal ganglion cell axon guidance (GO:0031290)2.61931952
125odontogenesis of dentin-containing tooth (GO:0042475)2.61380988
126odontogenesis (GO:0042476)2.59698647
127head development (GO:0060322)2.59673170
128behavioral response to nicotine (GO:0035095)2.59557191
129hair follicle development (GO:0001942)2.58965648
130segment specification (GO:0007379)2.58143735
131nephron tubule formation (GO:0072079)2.57702788
132neuron fate commitment (GO:0048663)2.57571496
133cranial nerve development (GO:0021545)2.57143402
134somite development (GO:0061053)2.56896061
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.56474668
136spinal cord association neuron differentiation (GO:0021527)2.55958180
137auditory behavior (GO:0031223)2.55950286
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55874981
139neural tube development (GO:0021915)2.54578327
140neuron fate determination (GO:0048664)2.54196597
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53958004
142cell proliferation involved in kidney development (GO:0072111)2.53721950
143transmission of nerve impulse (GO:0019226)2.53395888
144pituitary gland development (GO:0021983)2.53332614
145craniofacial suture morphogenesis (GO:0097094)2.52363404
146heart valve morphogenesis (GO:0003179)2.52289378
147negative regulation of epidermis development (GO:0045683)2.52282240
148atrioventricular valve morphogenesis (GO:0003181)2.51177785
149regulation of embryonic development (GO:0045995)2.51120567
150viral transcription (GO:0019083)2.48808335
151olfactory bulb development (GO:0021772)2.45145897
152regulation of axon extension involved in axon guidance (GO:0048841)2.43120985
153regulation of axon guidance (GO:1902667)2.42909519
154establishment of nucleus localization (GO:0040023)2.39776536
155cerebellar granule cell differentiation (GO:0021707)2.37322304
156cranial nerve morphogenesis (GO:0021602)2.37127968
157establishment of mitochondrion localization (GO:0051654)2.36058825
158synapse assembly (GO:0007416)2.34711502
159translational termination (GO:0006415)2.34312344
160positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.33900168
161positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.33664817
162forebrain development (GO:0030900)2.33568322
163enteric nervous system development (GO:0048484)2.32582264
164thalamus development (GO:0021794)2.31835862
165asymmetric protein localization (GO:0008105)2.30417680
166telencephalon development (GO:0021537)2.29410246
167pre-miRNA processing (GO:0031054)2.29258974
168semaphorin-plexin signaling pathway (GO:0071526)2.28444015
169positive regulation of neural precursor cell proliferation (GO:2000179)2.28362861
170body morphogenesis (GO:0010171)2.27586893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.74617817
2EZH2_22144423_ChIP-Seq_EOC_Human6.56602321
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.68162364
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76719764
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.58975841
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57400028
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57400028
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57400028
9E2F7_22180533_ChIP-Seq_HELA_Human2.57089947
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.48276138
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47289273
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.41705788
13* TP53_20018659_ChIP-ChIP_R1E_Mouse2.30027396
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.20032829
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19984077
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.14452137
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.11855852
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06292700
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99846862
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.99766609
21DROSHA_22980978_ChIP-Seq_HELA_Human1.98893149
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.95999224
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95068585
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91378526
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90445790
26* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86713069
27* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86713069
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83875349
29KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.82962421
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81526855
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79988642
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79842017
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79262855
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76902687
35REST_21632747_ChIP-Seq_MESCs_Mouse1.76846147
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74950801
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72530460
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70512248
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66508544
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.66502103
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.66084516
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65781004
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62780450
44* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62026331
45* CTCF_27219007_Chip-Seq_Bcells_Human1.60649864
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59163044
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53176284
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.52091887
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51553312
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51285487
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.51226478
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50412861
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49972859
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.49886444
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.49124510
56* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48137606
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45621074
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45565100
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44150437
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42822469
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41660636
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41577198
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.40915682
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40788846
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40443988
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40170739
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39901249
68RNF2_27304074_Chip-Seq_NSC_Mouse1.39745475
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.38058161
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34547345
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34429154
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.30677396
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28404760
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26492438
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25878176
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25874770
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25838911
78TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24915559
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.24899317
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24779479
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24132460
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23336142
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23266238
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22795050
85KDM2B_26808549_Chip-Seq_K562_Human1.21710093
86* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20722863
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.15781475
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15572207
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15572207
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14894968
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12675290
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11415062
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09482398
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07993366
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07750110
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.07717067
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07681677
98* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05719945
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05249962
100ZNF263_19887448_ChIP-Seq_K562_Human1.04346808
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04153555
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03241245
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03073598
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03027798
105NANOG_16153702_ChIP-ChIP_HESCs_Human1.02679406
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01671728
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01644978
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01580191
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.01363603
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99595276
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99407602
112RACK7_27058665_Chip-Seq_MCF-7_Human0.98603871
113LXR_22292898_ChIP-Seq_THP-1_Human0.98332948
114SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97891716
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97769644
116AR_21572438_ChIP-Seq_LNCaP_Human0.97149969
117CLOCK_20551151_ChIP-Seq_293T_Human0.97066612
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96225819
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95768400
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95638194
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95297259
122NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94757253
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.94728114
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.93950684
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.92695741
126* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91766639
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91469421
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91129483
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89420798
130AR_19668381_ChIP-Seq_PC3_Human0.88814927
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88720089
132* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88435192
133GBX2_23144817_ChIP-Seq_PC3_Human0.87991979
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87412343
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87122435
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86193555
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83390903
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81336259
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80358944
140MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.79235983
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.77898315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.91574651
2MP0009379_abnormal_foot_pigmentation3.29073457
3MP0000537_abnormal_urethra_morphology2.93971351
4MP0000566_synostosis2.86111373
5MP0003941_abnormal_skin_development2.77894930
6MP0002249_abnormal_larynx_morphology2.64907974
7MP0003880_abnormal_central_pattern2.61468594
8MP0006292_abnormal_olfactory_placode2.59666915
9MP0000049_abnormal_middle_ear2.47213809
10MP0005275_abnormal_skin_tensile2.35257083
11MP0004859_abnormal_synaptic_plasticity2.33849298
12MP0009053_abnormal_anal_canal2.19388704
13MP0000467_abnormal_esophagus_morphology2.11938768
14MP0002653_abnormal_ependyma_morphology2.08387063
15MP0000762_abnormal_tongue_morphology2.07610013
16MP0003878_abnormal_ear_physiology2.07209955
17MP0005377_hearing/vestibular/ear_phenot2.07209955
18MP0003705_abnormal_hypodermis_morpholog2.03515490
19MP0002796_impaired_skin_barrier2.02950097
20MP0000428_abnormal_craniofacial_morphol2.01243259
21MP0002282_abnormal_trachea_morphology1.98717942
22MP0005423_abnormal_somatic_nervous1.97241212
23MP0002254_reproductive_system_inflammat1.96197438
24MP0009250_abnormal_appendicular_skeleto1.95287260
25MP0000579_abnormal_nail_morphology1.94599902
26MP0003937_abnormal_limbs/digits/tail_de1.91996404
27MP0003385_abnormal_body_wall1.91781953
28MP0005503_abnormal_tendon_morphology1.90496348
29MP0003283_abnormal_digestive_organ1.89546805
30MP0003942_abnormal_urinary_system1.88235820
31MP0004885_abnormal_endolymph1.84434931
32MP0003755_abnormal_palate_morphology1.83090878
33MP0000383_abnormal_hair_follicle1.82052726
34MP0004272_abnormal_basement_membrane1.78805999
35MP0002098_abnormal_vibrissa_morphology1.74366017
36MP0002234_abnormal_pharynx_morphology1.73521374
37MP0008438_abnormal_cutaneous_collagen1.72577319
38MP0010234_abnormal_vibrissa_follicle1.69537450
39MP0002233_abnormal_nose_morphology1.67393976
40MP0006276_abnormal_autonomic_nervous1.64230017
41MP0000647_abnormal_sebaceous_gland1.62856546
42MP0010678_abnormal_skin_adnexa1.62385303
43MP0003787_abnormal_imprinting1.62230421
44MP0000534_abnormal_ureter_morphology1.58811876
45MP0001346_abnormal_lacrimal_gland1.58627981
46MP0003938_abnormal_ear_development1.57517483
47MP0005076_abnormal_cell_differentiation1.52087212
48MP0003119_abnormal_digestive_system1.49921084
49MP0005508_abnormal_skeleton_morphology1.48888472
50MP0002111_abnormal_tail_morphology1.47740843
51MP0002932_abnormal_joint_morphology1.47572758
52MP0008789_abnormal_olfactory_epithelium1.47482492
53MP0003315_abnormal_perineum_morphology1.47364660
54MP0000955_abnormal_spinal_cord1.46690008
55MP0002116_abnormal_craniofacial_bone1.46584282
56MP0003115_abnormal_respiratory_system1.45913549
57MP0002060_abnormal_skin_morphology1.45863024
58MP0003635_abnormal_synaptic_transmissio1.44807884
59MP0003935_abnormal_craniofacial_develop1.44024990
60MP0002822_catalepsy1.43242345
61MP0001849_ear_inflammation1.37940324
62MP0001299_abnormal_eye_distance/1.37812082
63MP0004133_heterotaxia1.35999625
64MP0005257_abnormal_intraocular_pressure1.35463959
65MP0001984_abnormal_olfaction1.34332047
66MP0000516_abnormal_urinary_system1.34153333
67MP0005367_renal/urinary_system_phenotyp1.34153333
68MP0001485_abnormal_pinna_reflex1.32353836
69MP0003122_maternal_imprinting1.31280072
70MP0001486_abnormal_startle_reflex1.30263510
71MP0000026_abnormal_inner_ear1.29501737
72MP0000432_abnormal_head_morphology1.29338802
73MP0002063_abnormal_learning/memory/cond1.29337632
74MP0005501_abnormal_skin_physiology1.29148256
75MP0002184_abnormal_innervation1.29066288
76MP0003890_abnormal_embryonic-extraembry1.26781513
77MP0004270_analgesia1.26595650
78MP0001293_anophthalmia1.26161747
79MP0002557_abnormal_social/conspecific_i1.23446027
80MP0002697_abnormal_eye_size1.22464574
81MP0005623_abnormal_meninges_morphology1.22271844
82MP0000631_abnormal_neuroendocrine_gland1.22157915
83MP0002938_white_spotting1.21762185
84MP0002734_abnormal_mechanical_nocicepti1.21717103
85MP0002152_abnormal_brain_morphology1.21314117
86MP0003123_paternal_imprinting1.21294313
87MP0000377_abnormal_hair_follicle1.21056251
88MP0001340_abnormal_eyelid_morphology1.20135311
89MP0000733_abnormal_muscle_development1.19567247
90MP0004197_abnormal_fetal_growth/weight/1.19350370
91MP0004381_abnormal_hair_follicle1.19268447
92MP0000462_abnormal_digestive_system1.17269542
93MP0002084_abnormal_developmental_patter1.17212373
94MP0000778_abnormal_nervous_system1.16929012
95MP0001286_abnormal_eye_development1.15640993
96MP0009384_cardiac_valve_regurgitation1.14478671
97MP0002882_abnormal_neuron_morphology1.13273785
98MP0002085_abnormal_embryonic_tissue1.12452513
99MP0002092_abnormal_eye_morphology1.11962128
100MP0003566_abnormal_cell_adhesion1.11768292
101MP0002272_abnormal_nervous_system1.11701246
102MP0000163_abnormal_cartilage_morphology1.11472670
103MP0003861_abnormal_nervous_system1.11371897
104MP0003453_abnormal_keratinocyte_physiol1.09886005
105MP0002752_abnormal_somatic_nervous1.09455991
106MP0002572_abnormal_emotion/affect_behav1.08470531
107MP0004134_abnormal_chest_morphology1.08223571
108MP0002109_abnormal_limb_morphology1.07656967
109MP0004858_abnormal_nervous_system1.07437240
110MP0001502_abnormal_circadian_rhythm1.07408997
111MP0001216_abnormal_epidermal_layer1.07317403
112MP0001529_abnormal_vocalization1.06757720
113MP0001188_hyperpigmentation1.06434974
114MP0005248_abnormal_Harderian_gland1.03096993
115MP0002177_abnormal_outer_ear1.02990058
116MP0002638_abnormal_pupillary_reflex1.01657695
117MP0002114_abnormal_axial_skeleton1.00266802
118MP0005394_taste/olfaction_phenotype1.00212526
119MP0005499_abnormal_olfactory_system1.00212526
120MP0004185_abnormal_adipocyte_glucose1.00076572
121MP0008932_abnormal_embryonic_tissue0.99199341
122MP0010771_integument_phenotype0.99065853
123MP0003136_yellow_coat_color0.96761160
124MP0003121_genomic_imprinting0.94868367
125MP0009745_abnormal_behavioral_response0.93071801
126MP0000678_abnormal_parathyroid_gland0.92499361
127MP0000427_abnormal_hair_cycle0.90140321
128MP0004811_abnormal_neuron_physiology0.90008921
129MP0002751_abnormal_autonomic_nervous0.88443971
130MP0002064_seizures0.87377791
131MP0002108_abnormal_muscle_morphology0.86360552
132MP0004142_abnormal_muscle_tone0.86340412
133MP0003567_abnormal_fetal_cardiomyocyte0.85420858
134MP0001963_abnormal_hearing_physiology0.85357253
135MP0005409_darkened_coat_color0.85063343
136MP0006054_spinal_hemorrhage0.82495940
137MP0005195_abnormal_posterior_eye0.80317799
138MP0001958_emphysema0.79905108
139MP0002081_perinatal_lethality0.79585640
140MP0002115_abnormal_skeleton_extremities0.79044966
141MP0004742_abnormal_vestibular_system0.76106392
142MP0003279_aneurysm0.75454386
143MP0002067_abnormal_sensory_capabilities0.74797903
144MP0006072_abnormal_retinal_apoptosis0.74470506

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.41835132
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.30865428
3Short 4th metacarpal (HP:0010044)3.30865428
4Milia (HP:0001056)3.12680470
5Atrophic scars (HP:0001075)3.04775733
6Rib fusion (HP:0000902)2.97383047
7Down-sloping shoulders (HP:0200021)2.95969814
8Fragile nails (HP:0001808)2.87063715
9Myokymia (HP:0002411)2.86789918
10Turricephaly (HP:0000262)2.84466526
11Coronal craniosynostosis (HP:0004440)2.83880505
12Hypotrichosis (HP:0001006)2.82543109
13Obstructive sleep apnea (HP:0002870)2.81193584
14Neonatal short-limb short stature (HP:0008921)2.79532372
15Hepatoblastoma (HP:0002884)2.76239131
16Esophageal atresia (HP:0002032)2.75977684
17Selective tooth agenesis (HP:0001592)2.73158441
18Vitreoretinal degeneration (HP:0000655)2.68932522
19Abnormality of the 4th metacarpal (HP:0010012)2.68315339
20Aplasia involving bones of the upper limbs (HP:0009823)2.65868281
21Aplasia of the phalanges of the hand (HP:0009802)2.65868281
22Aplasia involving bones of the extremities (HP:0009825)2.65868281
23Alacrima (HP:0000522)2.64425629
24Premature rupture of membranes (HP:0001788)2.52147309
25Concave nail (HP:0001598)2.48082735
26Renal duplication (HP:0000075)2.46972367
27Protrusio acetabuli (HP:0003179)2.46099877
28Woolly hair (HP:0002224)2.45474643
29Anophthalmia (HP:0000528)2.42078653
30Bronchomalacia (HP:0002780)2.41093689
31Sleep apnea (HP:0010535)2.38310861
32Morphological abnormality of the middle ear (HP:0008609)2.35798814
33Ankle contracture (HP:0006466)2.26865549
34Aplasia cutis congenita (HP:0001057)2.26210539
35High anterior hairline (HP:0009890)2.24892106
36Pili torti (HP:0003777)2.22538982
37Abnormal number of incisors (HP:0011064)2.20713911
38Abnormality of the middle phalanges of the toes (HP:0010183)2.20292910
39Natal tooth (HP:0000695)2.17025244
40Hypoplastic ischia (HP:0003175)2.14735825
41Partial duplication of the phalanx of hand (HP:0009999)2.14504050
42Right ventricular cardiomyopathy (HP:0011663)2.14401229
43Mixed hearing impairment (HP:0000410)2.14257744
44Decreased lacrimation (HP:0000633)2.13342231
45Abnormality of the ischium (HP:0003174)2.12293186
46Maternal diabetes (HP:0009800)2.10792192
47Overriding aorta (HP:0002623)2.10674098
48Bladder diverticulum (HP:0000015)2.06787491
49Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.06266783
50Fragile skin (HP:0001030)2.05001167
51Absent septum pellucidum (HP:0001331)2.04469589
52Oligodactyly (HP:0012165)2.02369035
53Synostosis of carpal bones (HP:0005048)2.00275746
54Broad toe (HP:0001837)1.99931429
55Megalencephaly (HP:0001355)1.97908167
56Deviation of the hallux (HP:0010051)1.95572423
57Broad finger (HP:0001500)1.94859745
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94232899
59Duplication of thumb phalanx (HP:0009942)1.93938368
60Midline defect of the nose (HP:0004122)1.93071499
61Optic nerve hypoplasia (HP:0000609)1.92673125
62Broad phalanges of the hand (HP:0009768)1.92517467
63Atresia of the external auditory canal (HP:0000413)1.92487259
64Broad hallux (HP:0010055)1.92007695
65Abnormality of the parietal bone (HP:0002696)1.91511110
66Pterygium (HP:0001059)1.91119734
67Advanced eruption of teeth (HP:0006288)1.90981890
68Abnormality of the lacrimal duct (HP:0011481)1.90362473
69Abnormality of the antihelix (HP:0009738)1.90183405
70Morphological abnormality of the inner ear (HP:0011390)1.89155033
71Abnormality of the nasolacrimal system (HP:0000614)1.89118804
72Renovascular hypertension (HP:0100817)1.89004441
73Broad long bones (HP:0005622)1.88077098
74Synostosis involving the elbow (HP:0003938)1.87669160
75Humeroradial synostosis (HP:0003041)1.87669160
76Partial duplication of thumb phalanx (HP:0009944)1.87667633
77Aplasia/Hypoplasia of the sternum (HP:0006714)1.86350266
78Wide anterior fontanel (HP:0000260)1.85658449
79Onycholysis (HP:0001806)1.85304321
80Hallux valgus (HP:0001822)1.84975092
81Broad phalanx (HP:0006009)1.83605008
82Hyperacusis (HP:0010780)1.83366083
83Septo-optic dysplasia (HP:0100842)1.82634606
84Bowel diverticulosis (HP:0005222)1.82329389
85Broad metatarsal (HP:0001783)1.82297867
86Preaxial foot polydactyly (HP:0001841)1.81817016
87Sex reversal (HP:0012245)1.81487361
88Abnormal sex determination (HP:0012244)1.81487361
89Tracheomalacia (HP:0002779)1.81425636
90Nasolacrimal duct obstruction (HP:0000579)1.81253353
91Ankyloglossia (HP:0010296)1.81233972
92Renal dysplasia (HP:0000110)1.80990405
93Cutaneous finger syndactyly (HP:0010554)1.79374358
94Ridged nail (HP:0001807)1.78706080
95Plantar hyperkeratosis (HP:0007556)1.77003065
96Reticulocytopenia (HP:0001896)1.76791853
97Abnormality of the diencephalon (HP:0010662)1.76494132
98Hypoplasia of the ulna (HP:0003022)1.76096636
99Tarsal synostosis (HP:0008368)1.75253330
100Arnold-Chiari malformation (HP:0002308)1.75142387
101Chin dimple (HP:0010751)1.73791699
102Broad thumb (HP:0011304)1.73056433
103Lip pit (HP:0100267)1.72342332
104Overgrowth (HP:0001548)1.71581047
105Flat cornea (HP:0007720)1.71219384
106Hypoplastic labia majora (HP:0000059)1.70932032
107Increased nuchal translucency (HP:0010880)1.70393072
108Megalocornea (HP:0000485)1.70307405
109Carpal synostosis (HP:0009702)1.69289805
110Trigonocephaly (HP:0000243)1.69082228
111Skull defect (HP:0001362)1.69029219
112Aplasia involving forearm bones (HP:0009822)1.67792784
113Absent forearm bone (HP:0003953)1.67792784
114Choanal stenosis (HP:0000452)1.67695582
115Neoplasm of the heart (HP:0100544)1.67527569
116Elfin facies (HP:0004428)1.66638629
117Abnormality of the intervertebral disk (HP:0005108)1.66576054
118Hypoplastic pelvis (HP:0008839)1.66179236
119Abnormality of the aortic arch (HP:0012303)1.65912373
120Oligodactyly (hands) (HP:0001180)1.65893853
121Type 1 muscle fiber predominance (HP:0003803)1.65873106
122Supernumerary ribs (HP:0005815)1.64712998
123Split foot (HP:0001839)1.64660967
124Synostosis involving bones of the lower limbs (HP:0009138)1.64300370
125Synostosis involving bones of the feet (HP:0009140)1.64300370
126Skin tags (HP:0010609)1.64146043
127Hypoventilation (HP:0002791)1.63933757
128Bilateral microphthalmos (HP:0007633)1.63688614
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63362577
130Cutaneous syndactyly (HP:0012725)1.63253125
131Short phalanx of the thumb (HP:0009660)1.62775795
132Abnormality of the labia minora (HP:0012880)1.61664566
133Vertebral clefting (HP:0008428)1.60160212
134Thin ribs (HP:0000883)1.60061522
135Abnormality of the septum pellucidum (HP:0007375)1.59078850
136Limited hip movement (HP:0008800)1.58722320
137Abnormality of the incisor (HP:0000676)1.58535033
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57808931
139Absent epiphyses (HP:0010577)1.57808931
140Shawl scrotum (HP:0000049)1.57789350
141Abdominal situs inversus (HP:0003363)1.56791987
142Abnormality of abdominal situs (HP:0011620)1.56791987
143Epiphyseal dysplasia (HP:0002656)1.56002658
144Abnormality of dentin (HP:0010299)1.55916557
145Abnormality of the lower motor neuron (HP:0002366)1.55094957
146Spina bifida occulta (HP:0003298)1.53346344
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52591435
148Genetic anticipation (HP:0003743)1.52581954
149Pointed chin (HP:0000307)1.52225863
150Insomnia (HP:0100785)1.52118403
151Omphalocele (HP:0001539)1.50264930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.87631079
2MARK13.10319515
3EPHA42.89415731
4KSR12.61293791
5CASK2.56504532
6TRIB32.56174738
7LATS12.47769067
8ICK2.38812998
9NTRK32.29492878
10PASK2.23135036
11DDR22.20016566
12SIK12.14549554
13MAP3K101.99223863
14LATS21.97231013
15RPS6KB21.88119500
16PDGFRA1.83499579
17BCR1.83013883
18BUB11.81136490
19ERBB21.80112920
20FER1.71871397
21TYRO31.70188060
22EEF2K1.65360219
23MKNK11.56137812
24TLK11.52682505
25FGFR11.47798037
26NTRK21.47292327
27SGK4941.46022255
28SGK2231.46022255
29CDK121.44468271
30PNCK1.39844843
31DMPK1.39183097
32CAMK1G1.36039176
33CAMK1D1.35635362
34PTK61.33691710
35MARK21.32834769
36EPHA21.28899982
37MET1.27714467
38MAP3K91.26812955
39STK38L1.22714677
40FGFR21.20691964
41LIMK11.18907724
42CDK71.14405970
43ERBB31.13948765
44SRPK11.13348064
45PAK41.13242719
46EPHA31.11819769
47PKN21.11524025
48MTOR1.10424990
49SIK31.09431157
50CDC71.07747883
51RIPK11.07038771
52BMX1.06765418
53DYRK1B1.05581134
54TTN1.03639610
55ROCK21.03078410
56MINK11.02247372
57PINK10.99599435
58ILK0.97526126
59PAK20.97012340
60STK110.96829554
61MAPKAPK30.95159019
62PRKCG0.94666998
63PRKCH0.94448655
64CAMK10.94063217
65PTK20.94034753
66SGK20.93817808
67UHMK10.90926319
68ROCK10.90776627
69TNIK0.90278847
70PKN10.90047815
71PRKCI0.87994960
72MKNK20.87584536
73LRRK20.85207413
74CAMKK10.84072666
75DYRK30.83830629
76SIK20.82141545
77CDK50.79567570
78DYRK1A0.78528249
79TTK0.77887434
80TAF10.77329053
81TSSK60.77067764
82PHKG20.76561588
83PHKG10.76561588
84MAPK150.74732647
85CDK60.73274139
86NTRK10.72277680
87CDC42BPA0.70129197
88MAP3K60.70044547
89RPS6KL10.69813266
90RPS6KC10.69813266
91CDK190.68651239
92MAP2K20.68307390
93MAP3K40.67613490
94NEK20.66986102
95INSRR0.66981195
96DYRK20.66109084
97NEK10.65950081
98AURKB0.64860090
99CDK150.64558860
100AKT20.64407340
101MAP3K20.64341399
102CDK11A0.64187200
103RPS6KA60.63942954
104MAP3K30.63626409
105TGFBR10.62389717
106PAK60.61104629
107PRKD30.59697736
108NME10.59395387
109RPS6KA10.57724097
110TESK10.57060416
111MAP2K40.56507892
112BRD40.56126100
113CLK10.55737766
114SGK30.55586738
115LMTK20.53141947
116PLK40.52981412
117WEE10.50734697
118CHEK10.50340088
119MST1R0.49955520
120MAPK130.49463588
121CDK140.48936228
122STK30.48171633
123PDGFRB0.48007166
124CDK180.47264596
125CDK20.47047203
126CSNK1D0.46889770
127SGK10.46382518
128PRKD20.45240010
129PLK10.44803400
130AKT10.44684900
131PAK30.44585076
132RPS6KA20.44580521
133MAPK90.44210655
134PRKD10.44107552
135CDK30.43654733
136MAP3K70.43644287
137CHEK20.42459225
138CDK10.42213402
139MAP2K70.41635977
140CSNK1E0.41577174
141PRKCZ0.41036086
142MAPKAPK20.40866919
143CAMK40.40757827
144MAPK70.40326135
145WNK10.39289306
146PRKDC0.38773845
147MAPK100.37925497

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.16827117
2Hedgehog signaling pathway_Homo sapiens_hsa043404.35621083
3Hippo signaling pathway_Homo sapiens_hsa043903.44385569
4Notch signaling pathway_Homo sapiens_hsa043302.86919901
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.82822617
6Axon guidance_Homo sapiens_hsa043602.34912792
7ECM-receptor interaction_Homo sapiens_hsa045122.27298535
8MicroRNAs in cancer_Homo sapiens_hsa052062.18109498
9Nicotine addiction_Homo sapiens_hsa050332.17549874
10Wnt signaling pathway_Homo sapiens_hsa043102.11667525
11TGF-beta signaling pathway_Homo sapiens_hsa043502.07438813
12Spliceosome_Homo sapiens_hsa030402.06549752
13Bladder cancer_Homo sapiens_hsa052191.97236044
14Adherens junction_Homo sapiens_hsa045201.96731769
15Melanogenesis_Homo sapiens_hsa049161.92683888
16Ribosome_Homo sapiens_hsa030101.87582662
17Proteoglycans in cancer_Homo sapiens_hsa052051.85657544
18Tight junction_Homo sapiens_hsa045301.80877997
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79920841
20Glutamatergic synapse_Homo sapiens_hsa047241.74629585
21Circadian entrainment_Homo sapiens_hsa047131.73603622
22mRNA surveillance pathway_Homo sapiens_hsa030151.72191217
23Cocaine addiction_Homo sapiens_hsa050301.71967623
24GABAergic synapse_Homo sapiens_hsa047271.57035969
25Focal adhesion_Homo sapiens_hsa045101.55041549
26Cell cycle_Homo sapiens_hsa041101.51315658
27Cardiac muscle contraction_Homo sapiens_hsa042601.47796928
28Insulin secretion_Homo sapiens_hsa049111.47166057
29Morphine addiction_Homo sapiens_hsa050321.44810588
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42199257
31Protein digestion and absorption_Homo sapiens_hsa049741.41311046
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39020157
33Dopaminergic synapse_Homo sapiens_hsa047281.38128617
34Pathways in cancer_Homo sapiens_hsa052001.37854011
35Cholinergic synapse_Homo sapiens_hsa047251.33499760
36Small cell lung cancer_Homo sapiens_hsa052221.31922077
37DNA replication_Homo sapiens_hsa030301.30999779
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25488087
39Endometrial cancer_Homo sapiens_hsa052131.24370117
40Gastric acid secretion_Homo sapiens_hsa049711.21555679
41RNA transport_Homo sapiens_hsa030131.21436093
42HTLV-I infection_Homo sapiens_hsa051661.21263059
43Melanoma_Homo sapiens_hsa052181.20725914
44Amphetamine addiction_Homo sapiens_hsa050311.15598483
45cAMP signaling pathway_Homo sapiens_hsa040241.14327985
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.11960571
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11188377
48Mismatch repair_Homo sapiens_hsa034301.11014688
49Colorectal cancer_Homo sapiens_hsa052101.09336103
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08613332
51Prostate cancer_Homo sapiens_hsa052151.06807509
52p53 signaling pathway_Homo sapiens_hsa041151.04535308
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.02730374
54Phototransduction_Homo sapiens_hsa047441.01933836
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01568649
56Renal cell carcinoma_Homo sapiens_hsa052111.01353496
57Chronic myeloid leukemia_Homo sapiens_hsa052201.01292688
58Dorso-ventral axis formation_Homo sapiens_hsa043201.00201419
59Base excision repair_Homo sapiens_hsa034100.97358231
60Long-term depression_Homo sapiens_hsa047300.95996673
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95985725
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95791879
63Glioma_Homo sapiens_hsa052140.94264803
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93765678
65Serotonergic synapse_Homo sapiens_hsa047260.90599470
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89041827
67Dilated cardiomyopathy_Homo sapiens_hsa054140.88097835
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.87841040
69ErbB signaling pathway_Homo sapiens_hsa040120.86833151
70Synaptic vesicle cycle_Homo sapiens_hsa047210.86437841
71Rap1 signaling pathway_Homo sapiens_hsa040150.86196162
72Gap junction_Homo sapiens_hsa045400.85882778
73Lysine degradation_Homo sapiens_hsa003100.84667747
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84506971
75Taste transduction_Homo sapiens_hsa047420.82667488
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82258991
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82252533
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81583023
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81299697
80Long-term potentiation_Homo sapiens_hsa047200.77467245
81Thyroid cancer_Homo sapiens_hsa052160.77357191
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77288781
83Salivary secretion_Homo sapiens_hsa049700.75714706
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75113551
85Calcium signaling pathway_Homo sapiens_hsa040200.74981471
86Oocyte meiosis_Homo sapiens_hsa041140.74954037
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73563529
88Renin secretion_Homo sapiens_hsa049240.72565439
89Amoebiasis_Homo sapiens_hsa051460.71413882
90One carbon pool by folate_Homo sapiens_hsa006700.71265896
91Estrogen signaling pathway_Homo sapiens_hsa049150.70311778
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69016525
93Fatty acid biosynthesis_Homo sapiens_hsa000610.68539881
94Viral myocarditis_Homo sapiens_hsa054160.68533711
95mTOR signaling pathway_Homo sapiens_hsa041500.67405969
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67297450
97Olfactory transduction_Homo sapiens_hsa047400.67214987
98Thyroid hormone synthesis_Homo sapiens_hsa049180.65226399
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65117405
100Ovarian steroidogenesis_Homo sapiens_hsa049130.64416778
101Non-small cell lung cancer_Homo sapiens_hsa052230.63907125
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62856489
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62266947
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61612225
105Bile secretion_Homo sapiens_hsa049760.58490162
106Nucleotide excision repair_Homo sapiens_hsa034200.57333851
107Choline metabolism in cancer_Homo sapiens_hsa052310.56872138
108VEGF signaling pathway_Homo sapiens_hsa043700.56119009
109Alcoholism_Homo sapiens_hsa050340.54178979
110Ras signaling pathway_Homo sapiens_hsa040140.52636726
111GnRH signaling pathway_Homo sapiens_hsa049120.51574110
112Viral carcinogenesis_Homo sapiens_hsa052030.51401362
113Steroid biosynthesis_Homo sapiens_hsa001000.49984377
114Pancreatic cancer_Homo sapiens_hsa052120.49441981
115Histidine metabolism_Homo sapiens_hsa003400.48393352
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.47654380
117Linoleic acid metabolism_Homo sapiens_hsa005910.47042295
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.46144418
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.45934066
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44783460
121AMPK signaling pathway_Homo sapiens_hsa041520.44489396
122Parkinsons disease_Homo sapiens_hsa050120.43902426
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43775531
124Huntingtons disease_Homo sapiens_hsa050160.43589917
125RNA polymerase_Homo sapiens_hsa030200.43254680
126beta-Alanine metabolism_Homo sapiens_hsa004100.42600687
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.42128981
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40766351
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40675025
130Homologous recombination_Homo sapiens_hsa034400.40665978
131Prion diseases_Homo sapiens_hsa050200.40172937
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39260981
133Alzheimers disease_Homo sapiens_hsa050100.38907687
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38696658
135MAPK signaling pathway_Homo sapiens_hsa040100.37369509
136Insulin signaling pathway_Homo sapiens_hsa049100.37189884
137Systemic lupus erythematosus_Homo sapiens_hsa053220.36070315
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34246132
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30464164
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29908700
141RNA degradation_Homo sapiens_hsa030180.28924321
142HIF-1 signaling pathway_Homo sapiens_hsa040660.26941959
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26598985
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26502488
145Endocytosis_Homo sapiens_hsa041440.26344872
146Oxytocin signaling pathway_Homo sapiens_hsa049210.25256140

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