EFTUD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.36025844
2DNA strand elongation involved in DNA replication (GO:0006271)4.65335675
3DNA replication initiation (GO:0006270)4.65166447
4nuclear pore organization (GO:0006999)4.63483218
5protein localization to kinetochore (GO:0034501)4.57832694
6proline biosynthetic process (GO:0006561)4.52039506
7DNA strand elongation (GO:0022616)4.43512511
8nuclear pore complex assembly (GO:0051292)4.41275281
9DNA strand renaturation (GO:0000733)4.19943852
10DNA replication-dependent nucleosome organization (GO:0034723)4.19054939
11DNA replication-dependent nucleosome assembly (GO:0006335)4.19054939
12telomere maintenance via semi-conservative replication (GO:0032201)4.13766828
13DNA topological change (GO:0006265)4.11177199
14mitotic nuclear envelope disassembly (GO:0007077)4.08092734
15IMP biosynthetic process (GO:0006188)4.02428361
16protein localization to chromosome, centromeric region (GO:0071459)3.94162146
17nucleobase biosynthetic process (GO:0046112)3.88655316
18nuclear envelope disassembly (GO:0051081)3.79915736
19membrane disassembly (GO:0030397)3.79915736
20Golgi transport vesicle coating (GO:0048200)3.77116135
21COPI coating of Golgi vesicle (GO:0048205)3.77116135
22formation of translation preinitiation complex (GO:0001731)3.76771527
23DNA duplex unwinding (GO:0032508)3.70790410
24folic acid-containing compound biosynthetic process (GO:0009396)3.70222674
25DNA geometric change (GO:0032392)3.68978079
26telomere maintenance via recombination (GO:0000722)3.67655196
27mitotic sister chromatid segregation (GO:0000070)3.65359652
28DNA replication checkpoint (GO:0000076)3.62078757
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.61195322
30somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61195322
31mitotic recombination (GO:0006312)3.61179165
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.61026309
33mitotic metaphase plate congression (GO:0007080)3.60353621
34nucleobase-containing small molecule interconversion (GO:0015949)3.54741592
35kinetochore organization (GO:0051383)3.52025121
36regulation of helicase activity (GO:0051095)3.46784356
37telomere maintenance via telomere lengthening (GO:0010833)3.46596034
38sister chromatid segregation (GO:0000819)3.46500023
39mitotic chromosome condensation (GO:0007076)3.45864364
40chromosome condensation (GO:0030261)3.43214030
41heterochromatin organization (GO:0070828)3.43038185
42IMP metabolic process (GO:0046040)3.41040763
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39356780
44establishment of integrated proviral latency (GO:0075713)3.38708067
45regulation of translational termination (GO:0006449)3.38533290
46folic acid metabolic process (GO:0046655)3.38344818
47regulation of gene silencing by RNA (GO:0060966)3.37672917
48regulation of posttranscriptional gene silencing (GO:0060147)3.37672917
49regulation of gene silencing by miRNA (GO:0060964)3.37672917
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.37099521
51double-strand break repair via nonhomologous end joining (GO:0006303)3.36871843
52non-recombinational repair (GO:0000726)3.36871843
53protein complex localization (GO:0031503)3.36749900
54pore complex assembly (GO:0046931)3.36058663
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.34423770
56nuclear envelope reassembly (GO:0031468)3.33681317
57mitotic nuclear envelope reassembly (GO:0007084)3.33681317
58purine nucleobase biosynthetic process (GO:0009113)3.31774996
59regulation of histone H3-K9 methylation (GO:0051570)3.30575005
60establishment of viral latency (GO:0019043)3.29701413
61tRNA aminoacylation for protein translation (GO:0006418)3.29315535
62chromatin remodeling at centromere (GO:0031055)3.26661952
63peptidyl-arginine omega-N-methylation (GO:0035247)3.24226828
64regulation of mitotic spindle organization (GO:0060236)3.23115046
65metaphase plate congression (GO:0051310)3.23062281
66negative regulation of RNA splicing (GO:0033119)3.22731238
67pre-miRNA processing (GO:0031054)3.22556908
68amino acid activation (GO:0043038)3.22230088
69tRNA aminoacylation (GO:0043039)3.22230088
70negative regulation of histone methylation (GO:0031061)3.22114913
71ribosome biogenesis (GO:0042254)3.20183270
72maturation of SSU-rRNA (GO:0030490)3.18982547
73spliceosomal snRNP assembly (GO:0000387)3.16208688
74mitotic sister chromatid cohesion (GO:0007064)3.14764210
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14528506
76CENP-A containing nucleosome assembly (GO:0034080)3.13817923
77positive regulation of chromosome segregation (GO:0051984)3.13568853
78negative regulation of chromosome segregation (GO:0051985)3.12907576
79histone H2A acetylation (GO:0043968)3.12646195
80attachment of spindle microtubules to kinetochore (GO:0008608)3.12190782
81proteasome assembly (GO:0043248)3.10424305
82negative regulation of mRNA processing (GO:0050686)3.10192419
83DNA replication-independent nucleosome assembly (GO:0006336)3.09218480
84DNA replication-independent nucleosome organization (GO:0034724)3.09218480
85* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08852740
86* mRNA splicing, via spliceosome (GO:0000398)3.08852740
87spindle assembly checkpoint (GO:0071173)3.08009106
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07885426
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07885426
90negative regulation of sister chromatid segregation (GO:0033046)3.07885426
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.07885426
92kinetochore assembly (GO:0051382)3.07737804
93DNA ligation (GO:0006266)3.07570536
94regulation of chromosome segregation (GO:0051983)3.06853952
95mitotic spindle assembly checkpoint (GO:0007094)3.06715701
96* RNA splicing, via transesterification reactions (GO:0000375)3.06626013
97cellular protein complex localization (GO:0034629)3.04509618
98regulation of translational fidelity (GO:0006450)3.02866456
99histone arginine methylation (GO:0034969)3.02401122
100establishment of chromosome localization (GO:0051303)3.02187036
101spindle checkpoint (GO:0031577)3.02007594
102DNA packaging (GO:0006323)3.02004853
103ribosome assembly (GO:0042255)3.00242077
104DNA conformation change (GO:0071103)2.99883806
105regulation of spindle organization (GO:0090224)2.99013846
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98933567
107peptidyl-arginine methylation (GO:0018216)2.98611073
108peptidyl-arginine N-methylation (GO:0035246)2.98611073
109chromosome segregation (GO:0007059)2.98133816
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97610108
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96880908
112mitotic spindle checkpoint (GO:0071174)2.95913349
113regulation of centrosome cycle (GO:0046605)2.95672597
114tRNA methylation (GO:0030488)2.95162859
115mismatch repair (GO:0006298)2.95151303
116negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94121162
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93897134
118chromatin assembly or disassembly (GO:0006333)2.93801576
119pentose-phosphate shunt (GO:0006098)2.93588071
120nuclear envelope organization (GO:0006998)2.92119309
121regulation of RNA export from nucleus (GO:0046831)2.91288709
122mRNA transport (GO:0051028)2.90714507
123chromatin assembly (GO:0031497)2.90230645
124peptidyl-lysine dimethylation (GO:0018027)2.89501373
125ribonucleoprotein complex biogenesis (GO:0022613)2.89477179
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88941519
127telomere organization (GO:0032200)2.88523842
128L-serine metabolic process (GO:0006563)2.88430125
129protein export from nucleus (GO:0006611)2.88241869
130regulation of sister chromatid cohesion (GO:0007063)2.87966862
131translesion synthesis (GO:0019985)2.87948767
132dosage compensation (GO:0007549)2.87891750
133regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87619430
134protein localization to chromosome (GO:0034502)2.87413631
135regulation of DNA damage checkpoint (GO:2000001)2.87272589
136NADPH regeneration (GO:0006740)2.86198987
137viral mRNA export from host cell nucleus (GO:0046784)2.86016290
138ATP-dependent chromatin remodeling (GO:0043044)2.85975031
139telomere maintenance (GO:0000723)2.85818228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.90031611
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.10944902
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06102073
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53760177
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26325311
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13230277
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78783870
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.68124703
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58529276
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42972216
11XRN2_22483619_ChIP-Seq_HELA_Human2.36044157
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35389822
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.32750102
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.26514460
15MYC_22102868_ChIP-Seq_BL_Human2.25834779
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25315252
17AR_21909140_ChIP-Seq_LNCAP_Human2.22614994
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15199456
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.12991138
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11831562
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09994911
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04633446
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04373907
24E2F7_22180533_ChIP-Seq_HELA_Human10.4358976
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93162689
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91579439
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87765442
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.86439626
29CIITA_25753668_ChIP-Seq_RAJI_Human1.81087857
30TTF2_22483619_ChIP-Seq_HELA_Human1.77502581
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74778004
32* VDR_23849224_ChIP-Seq_CD4+_Human1.74688542
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73567646
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72854603
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.72293999
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71762181
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68974890
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.67981934
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62179794
40GABP_19822575_ChIP-Seq_HepG2_Human1.59388692
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56692766
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56541868
43* DCP1A_22483619_ChIP-Seq_HELA_Human1.55553610
44ZNF263_19887448_ChIP-Seq_K562_Human1.54440343
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49680942
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47030221
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46723129
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45023056
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41346392
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40218032
51KDM5A_27292631_Chip-Seq_BREAST_Human1.39501453
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38115173
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34515291
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33529401
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32555897
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31184458
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31104676
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.30071304
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28062169
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27957208
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27308677
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24779321
63ELK1_19687146_ChIP-ChIP_HELA_Human1.22860779
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22784522
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22165137
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20456692
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20435803
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19067978
69VDR_21846776_ChIP-Seq_THP-1_Human1.18215883
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17596855
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15632585
72* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13884702
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12196803
74TFEB_21752829_ChIP-Seq_HELA_Human1.10210364
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09726933
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.09655448
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09093605
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08344399
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07038757
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04353628
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03879902
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03879902
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03879902
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01950458
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01063185
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99608398
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99517436
88CLOCK_20551151_ChIP-Seq_293T_Human0.98615392
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.97663816
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.96512458
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95985688
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95699956
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95634923
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95521097
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94498177
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94436910
97* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94077531
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93579551
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93537532
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.91149569
101SALL1_21062744_ChIP-ChIP_HESCs_Human0.90684292
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90622449
103MYC_18940864_ChIP-ChIP_HL60_Human0.90377960
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88488926
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86189746
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.85881372
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85121582
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84571828
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83883856
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83757293
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83314643
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83283395
113NCOR1_26117541_ChIP-Seq_K562_Human0.82453070
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82258918
115CHD1_26751641_Chip-Seq_LNCaP_Human0.81644952
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81131178
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81072289
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.80729761
119TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80231154
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79857454
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.78885067
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78310128
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78184509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.44394423
2MP0003111_abnormal_nucleus_morphology4.36685255
3MP0003693_abnormal_embryo_hatching4.24947877
4MP0004957_abnormal_blastocyst_morpholog3.84734159
5MP0003077_abnormal_cell_cycle3.73581310
6MP0008057_abnormal_DNA_replication3.47291429
7MP0008058_abnormal_DNA_repair2.99494909
8MP0002877_abnormal_melanocyte_morpholog2.79405747
9MP0008007_abnormal_cellular_replicative2.75114211
10MP0003123_paternal_imprinting2.55429663
11MP0008932_abnormal_embryonic_tissue2.51930215
12MP0010030_abnormal_orbit_morphology2.47588168
13MP0001730_embryonic_growth_arrest2.47520067
14MP0005451_abnormal_body_composition2.37281475
15MP0008877_abnormal_DNA_methylation2.34893373
16MP0000350_abnormal_cell_proliferation2.29228446
17MP0002396_abnormal_hematopoietic_system2.27257081
18MP0010352_gastrointestinal_tract_polyps2.16029603
19MP0003806_abnormal_nucleotide_metabolis2.06355486
20MP0003121_genomic_imprinting1.92349876
21MP0001672_abnormal_embryogenesis/_devel1.90063970
22MP0005380_embryogenesis_phenotype1.90063970
23MP0002085_abnormal_embryonic_tissue1.85727872
24MP0002653_abnormal_ependyma_morphology1.84889347
25MP0001697_abnormal_embryo_size1.83879774
26MP0010307_abnormal_tumor_latency1.82391787
27MP0004197_abnormal_fetal_growth/weight/1.80068237
28MP0002084_abnormal_developmental_patter1.77946895
29MP0008260_abnormal_autophagy1.76533893
30MP0003984_embryonic_growth_retardation1.71231852
31MP0005076_abnormal_cell_differentiation1.68351321
32MP0002088_abnormal_embryonic_growth/wei1.68233289
33MP0002080_prenatal_lethality1.66844045
34MP0009697_abnormal_copulation1.65377913
35MP0003786_premature_aging1.59729855
36MP0000537_abnormal_urethra_morphology1.58608724
37MP0005058_abnormal_lysosome_morphology1.57296752
38MP0002086_abnormal_extraembryonic_tissu1.53502042
39MP0004808_abnormal_hematopoietic_stem1.52825965
40MP0000490_abnormal_crypts_of1.44557519
41MP0001293_anophthalmia1.43599475
42MP0003718_maternal_effect1.41012266
43MP0003119_abnormal_digestive_system1.39610430
44MP0000358_abnormal_cell_content/1.38542091
45MP0000313_abnormal_cell_death1.37991399
46MP0000566_synostosis1.33162899
47MP0001661_extended_life_span1.32735385
48MP0004185_abnormal_adipocyte_glucose1.31951551
49MP0003890_abnormal_embryonic-extraembry1.30656782
50MP0003567_abnormal_fetal_cardiomyocyte1.25819610
51MP0002019_abnormal_tumor_incidence1.21199613
52MP0002009_preneoplasia1.17344165
53MP0002111_abnormal_tail_morphology1.16391634
54MP0009053_abnormal_anal_canal1.16329020
55MP0002210_abnormal_sex_determination1.15601438
56MP0000428_abnormal_craniofacial_morphol1.14616687
57MP0000703_abnormal_thymus_morphology1.13782363
58MP0004133_heterotaxia1.13156947
59MP0006035_abnormal_mitochondrial_morpho1.12552593
60MP0003937_abnormal_limbs/digits/tail_de1.11160914
61MP0002089_abnormal_postnatal_growth/wei1.10375970
62MP0009278_abnormal_bone_marrow1.09798813
63MP0003221_abnormal_cardiomyocyte_apopto1.05702320
64MP0006054_spinal_hemorrhage1.05449299
65MP0005501_abnormal_skin_physiology1.04972456
66MP0001915_intracranial_hemorrhage1.03339536
67MP0003861_abnormal_nervous_system1.00721919
68MP0005257_abnormal_intraocular_pressure1.00481828
69MP0002102_abnormal_ear_morphology0.99650737
70MP0010234_abnormal_vibrissa_follicle0.99293365
71MP0003315_abnormal_perineum_morphology0.99174089
72MP0003115_abnormal_respiratory_system0.99052356
73MP0000049_abnormal_middle_ear0.97571919
74MP0002166_altered_tumor_susceptibility0.93641807
75MP0001145_abnormal_male_reproductive0.92977520
76MP0003566_abnormal_cell_adhesion0.92946482
77MP0002092_abnormal_eye_morphology0.90524459
78MP0003941_abnormal_skin_development0.89009949
79MP0006292_abnormal_olfactory_placode0.88376644
80MP0002938_white_spotting0.87948759
81MP0004272_abnormal_basement_membrane0.85935670
82MP0002006_tumorigenesis0.83400623
83MP0003935_abnormal_craniofacial_develop0.83165581
84MP0000432_abnormal_head_morphology0.83005422
85MP0002398_abnormal_bone_marrow0.82663692
86MP0009703_decreased_birth_body0.82076540
87MP0003763_abnormal_thymus_physiology0.81407777
88MP0009672_abnormal_birth_weight0.80635157
89MP0001929_abnormal_gametogenesis0.80045438
90MP0001849_ear_inflammation0.79917571
91MP0001727_abnormal_embryo_implantation0.79558299
92MP0009333_abnormal_splenocyte_physiolog0.79113306
93MP0004233_abnormal_muscle_weight0.78621479
94MP0000678_abnormal_parathyroid_gland0.78581186
95MP0000733_abnormal_muscle_development0.78088394
96MP0001853_heart_inflammation0.78009171
97MP0002722_abnormal_immune_system0.77545425
98MP0005397_hematopoietic_system_phenotyp0.77225779
99MP0001545_abnormal_hematopoietic_system0.77225779
100MP0002249_abnormal_larynx_morphology0.76036507
101MP0003787_abnormal_imprinting0.75600314
102MP0001286_abnormal_eye_development0.75364423
103MP0004134_abnormal_chest_morphology0.74963395
104MP0002925_abnormal_cardiovascular_devel0.74814883
105MP0000653_abnormal_sex_gland0.74804047
106MP0002160_abnormal_reproductive_system0.74739545
107MP0003705_abnormal_hypodermis_morpholog0.74542814
108MP0001346_abnormal_lacrimal_gland0.73813368
109MP0002060_abnormal_skin_morphology0.73508967
110MP0002796_impaired_skin_barrier0.73352306
111MP0001216_abnormal_epidermal_layer0.72593740
112MP0003755_abnormal_palate_morphology0.72237928
113MP0005408_hypopigmentation0.71721469
114MP0002697_abnormal_eye_size0.70728710
115MP0005384_cellular_phenotype0.70438928
116MP0003122_maternal_imprinting0.70238701
117MP0000858_altered_metastatic_potential0.70023191
118MP0003453_abnormal_keratinocyte_physiol0.69706335
119MP0005623_abnormal_meninges_morphology0.68688333
120MP0003942_abnormal_urinary_system0.68412337
121MP0003283_abnormal_digestive_organ0.68102447
122MP0005621_abnormal_cell_physiology0.67565052
123MP0002269_muscular_atrophy0.66717707
124MP0008789_abnormal_olfactory_epithelium0.66023273
125MP0000689_abnormal_spleen_morphology0.65710321
126MP0003385_abnormal_body_wall0.65645579
127MP0002114_abnormal_axial_skeleton0.65477681
128MP0002116_abnormal_craniofacial_bone0.65177970
129MP0002932_abnormal_joint_morphology0.64885272
130MP0010630_abnormal_cardiac_muscle0.64868824
131MP0002075_abnormal_coat/hair_pigmentati0.64405070
132MP0003943_abnormal_hepatobiliary_system0.63961965
133MP0003656_abnormal_erythrocyte_physiolo0.60957440
134MP0001881_abnormal_mammary_gland0.59258802
135MP0001186_pigmentation_phenotype0.57985960
136MP0003950_abnormal_plasma_membrane0.56695188
137MP0000747_muscle_weakness0.56143248
138MP0000598_abnormal_liver_morphology0.55079193
139MP0005197_abnormal_uvea_morphology0.52284320
140MP0005464_abnormal_platelet_physiology0.51908755

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.27217337
2Microvesicular hepatic steatosis (HP:0001414)4.07943311
3Selective tooth agenesis (HP:0001592)3.89614954
4Medulloblastoma (HP:0002885)3.83885140
5Abnormality of glycolysis (HP:0004366)3.51303097
6Chromsome breakage (HP:0040012)3.45892048
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43163118
8Birth length less than 3rd percentile (HP:0003561)3.29827673
9Increased nuchal translucency (HP:0010880)3.29134072
10Achilles tendon contracture (HP:0001771)3.26225187
11Colon cancer (HP:0003003)3.24865248
12Abnormal gallbladder physiology (HP:0012438)3.23605258
13Cholecystitis (HP:0001082)3.23605258
14Agnosia (HP:0010524)3.21700703
15Abnormal number of incisors (HP:0011064)3.20721008
16Astrocytoma (HP:0009592)3.18803418
17Abnormality of the astrocytes (HP:0100707)3.18803418
18Reticulocytopenia (HP:0001896)3.07926394
19Increased serum pyruvate (HP:0003542)3.02381205
20Progressive muscle weakness (HP:0003323)2.90726789
21Abnormality of the Achilles tendon (HP:0005109)2.90288957
22Patellar aplasia (HP:0006443)2.88069670
23Glioma (HP:0009733)2.85809023
24Overlapping toe (HP:0001845)2.85567824
25* Proximal placement of thumb (HP:0009623)2.80841432
26Cortical dysplasia (HP:0002539)2.80321625
27Abnormality of chromosome stability (HP:0003220)2.74596197
28Ragged-red muscle fibers (HP:0003200)2.73938025
29* Deviation of the thumb (HP:0009603)2.73919933
30Meckel diverticulum (HP:0002245)2.73688541
31Abnormality of the ileum (HP:0001549)2.72783509
32Absent radius (HP:0003974)2.69663043
33Rhabdomyosarcoma (HP:0002859)2.67424002
34Aplasia/Hypoplasia of the patella (HP:0006498)2.65964981
35Degeneration of anterior horn cells (HP:0002398)2.63332786
36Abnormality of the anterior horn cell (HP:0006802)2.63332786
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61373917
38Short 4th metacarpal (HP:0010044)2.61373917
39Aplasia involving forearm bones (HP:0009822)2.61362757
40Absent forearm bone (HP:0003953)2.61362757
41High anterior hairline (HP:0009890)2.56167221
42Abnormality of the labia minora (HP:0012880)2.55327992
43Basal cell carcinoma (HP:0002671)2.50696287
44Abnormality of the preputium (HP:0100587)2.50623033
45Breast hypoplasia (HP:0003187)2.50087469
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.45725062
47Small intestinal stenosis (HP:0012848)2.44884530
48Duodenal stenosis (HP:0100867)2.44884530
49Ectopic kidney (HP:0000086)2.43998806
50Upper motor neuron abnormality (HP:0002127)2.42541034
51Reduced subcutaneous adipose tissue (HP:0003758)2.39888193
52Volvulus (HP:0002580)2.38166546
53Neoplasm of striated muscle (HP:0009728)2.38135355
5411 pairs of ribs (HP:0000878)2.36872420
55Amaurosis fugax (HP:0100576)2.36826287
56Progressive external ophthalmoplegia (HP:0000590)2.36144213
57Insomnia (HP:0100785)2.35782268
58Neoplasm of the pancreas (HP:0002894)2.33974735
59Abnormal lung lobation (HP:0002101)2.27248588
60Skull defect (HP:0001362)2.26009272
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.25878781
62Neoplasm of the oral cavity (HP:0100649)2.24677021
63Absent thumb (HP:0009777)2.23137582
64Abnormality of the carotid arteries (HP:0005344)2.22295232
65Spastic diplegia (HP:0001264)2.20711036
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.20083273
67Absent epiphyses (HP:0010577)2.20083273
68Multiple enchondromatosis (HP:0005701)2.18462724
69Myelodysplasia (HP:0002863)2.16826014
70Abnormality of oral frenula (HP:0000190)2.16323970
71Supernumerary spleens (HP:0009799)2.15526412
72Oral leukoplakia (HP:0002745)2.15234208
73Duplicated collecting system (HP:0000081)2.13024208
74Tracheoesophageal fistula (HP:0002575)2.11078537
75Ankyloglossia (HP:0010296)2.09090563
76Missing ribs (HP:0000921)2.08720289
77Elbow flexion contracture (HP:0002987)2.08500363
78Breech presentation (HP:0001623)2.07405767
79Secondary amenorrhea (HP:0000869)2.07087570
80Renal duplication (HP:0000075)2.06572608
81Orthostatic hypotension (HP:0001278)2.06232777
82Broad alveolar ridges (HP:0000187)2.05947690
83Broad distal phalanx of finger (HP:0009836)2.05798079
84Premature ovarian failure (HP:0008209)2.04229082
85Sloping forehead (HP:0000340)2.03788722
86Abnormality of the duodenum (HP:0002246)2.01986741
87Overriding aorta (HP:0002623)2.01823488
88Impulsivity (HP:0100710)2.01322129
89Premature graying of hair (HP:0002216)2.01205745
90Squamous cell carcinoma (HP:0002860)2.00584510
91Gastrointestinal carcinoma (HP:0002672)2.00133507
92Malignant gastrointestinal tract tumors (HP:0006749)2.00133507
93Type I transferrin isoform profile (HP:0003642)1.98585396
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97771312
95Carpal bone hypoplasia (HP:0001498)1.97322398
96Hyperacusis (HP:0010780)1.97081554
97High pitched voice (HP:0001620)1.97060441
98Cafe-au-lait spot (HP:0000957)1.96563941
99* Atresia of the external auditory canal (HP:0000413)1.94781290
100Horseshoe kidney (HP:0000085)1.94215480
101Abnormality of the umbilical cord (HP:0010881)1.92582193
102Nephroblastoma (Wilms tumor) (HP:0002667)1.92319529
103Ulnar bowing (HP:0003031)1.92110500
104Hypoplasia of the radius (HP:0002984)1.90529686
105Abnormality of reticulocytes (HP:0004312)1.90350101
106Short thumb (HP:0009778)1.90153387
107Abdominal situs inversus (HP:0003363)1.89953281
108Abnormality of abdominal situs (HP:0011620)1.89953281
109Asymmetry of the thorax (HP:0001555)1.89709349
110Abnormality of cells of the erythroid lineage (HP:0012130)1.89220753
111Cerebral hypomyelination (HP:0006808)1.88553708
112Rough bone trabeculation (HP:0100670)1.88254323
113Elfin facies (HP:0004428)1.84054993
114Triphalangeal thumb (HP:0001199)1.83348490
115Bone marrow hypocellularity (HP:0005528)1.83128731
116Prominent nose (HP:0000448)1.81889863
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.79354707
118Abnormal trabecular bone morphology (HP:0100671)1.79132333
119Embryonal renal neoplasm (HP:0011794)1.78757099
120Cholelithiasis (HP:0001081)1.78674720
121Duplication of thumb phalanx (HP:0009942)1.77823691
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77742935
123Small epiphyses (HP:0010585)1.77697934
124Biliary tract neoplasm (HP:0100574)1.77690384
125Abnormality of the renal collecting system (HP:0004742)1.76833797
126Termporal pattern (HP:0011008)1.76694237
127Insidious onset (HP:0003587)1.76694237
128Glossoptosis (HP:0000162)1.75955633
129Cellular immunodeficiency (HP:0005374)1.75811353
130Abnormality of the salivary glands (HP:0010286)1.74874528
131Reticulocytosis (HP:0001923)1.74283052
132Pseudobulbar signs (HP:0002200)1.74178297
133Abnormal number of erythroid precursors (HP:0012131)1.73654733
134Abnormality of the calcaneus (HP:0008364)1.72654661
135Patellar dislocation (HP:0002999)1.72382853
136Cutis marmorata (HP:0000965)1.72174879
137Progressive hearing impairment (HP:0001730)1.71947294
138Supernumerary bones of the axial skeleton (HP:0009144)1.70394479
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68037885
140Septate vagina (HP:0001153)1.67574395
141Slender long bone (HP:0003100)1.66947308
142Long eyelashes (HP:0000527)1.66744520
143Abnormality of the incisor (HP:0000676)1.65698622
144Supernumerary ribs (HP:0005815)1.65636089
145Abnormality of the 4th metacarpal (HP:0010012)1.64729507
146Abnormalities of placenta or umbilical cord (HP:0001194)1.64702534
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64663628
148Abnormal protein N-linked glycosylation (HP:0012347)1.64663628
149Abnormal protein glycosylation (HP:0012346)1.64663628
150Abnormal glycosylation (HP:0012345)1.64663628
151* Trigonocephaly (HP:0000243)1.64014037
152Large eyes (HP:0001090)1.62440260
153* Trismus (HP:0000211)1.61764684
154Nonimmune hydrops fetalis (HP:0001790)1.60439712
155Upper limb muscle weakness (HP:0003484)1.60338874
156Premature rupture of membranes (HP:0001788)1.60249385
157* Choanal atresia (HP:0000453)1.59045190
158Cutaneous melanoma (HP:0012056)1.58534181
159Pancytopenia (HP:0001876)1.58279166
160Urethral obstruction (HP:0000796)1.57703433
161Reduced antithrombin III activity (HP:0001976)1.57059028
162Abnormal umbilical cord blood vessels (HP:0011403)1.56554186
163Single umbilical artery (HP:0001195)1.56554186
164Abnormality of the fetal cardiovascular system (HP:0010948)1.56554186
165Entropion (HP:0000621)1.56506228
166* Deep philtrum (HP:0002002)1.56417341
167Hypergonadotropic hypogonadism (HP:0000815)1.55063960
168Microglossia (HP:0000171)1.54576352
169Poikiloderma (HP:0001029)1.54109535
170Abnormality of the fingertips (HP:0001211)1.52786424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.03602491
2BUB14.27082087
3PASK4.27040405
4CDC74.24480450
5WEE13.37362882
6SMG12.90407627
7PBK2.58835397
8NEK22.57816170
9CDK122.55306631
10TSSK62.49790450
11RPS6KB22.42518611
12TTK2.23051088
13MAP3K102.22736275
14MAPKAPK32.17951908
15IRAK32.03539590
16SRPK12.01200336
17MKNK11.89570091
18NEK11.87225585
19VRK21.81214025
20EIF2AK11.79953203
21PLK11.73328065
22ATR1.70977309
23TESK21.69634238
24MST1R1.67987948
25CDK71.66103898
26PAK41.59968331
27CDK41.55523942
28PKN21.49884832
29SCYL21.46687746
30ACVR1B1.43521045
31CHEK11.42002410
32AURKB1.41412941
33BRSK21.41038417
34TLK11.37860756
35PLK31.37375108
36STK101.34981952
37TGFBR11.27237118
38BRD41.22630747
39MKNK21.22435101
40EPHA21.22227382
41CHEK21.20144512
42MAP3K81.19205256
43CCNB11.17086204
44BRSK11.17002912
45DYRK31.13785852
46ALK1.11841906
47AURKA1.10432178
48RPS6KA41.08058958
49VRK11.04922624
50PNCK0.95568609
51PRPF4B0.95001886
52EIF2AK20.93541946
53FGFR10.92467250
54PLK40.92338279
55CDK20.91974920
56ATM0.90952713
57PDK20.86007345
58STK160.83310789
59MOS0.82849838
60FGFR40.82500260
61PTK20.81959513
62ERBB40.81600302
63STK40.80925849
64TAF10.79362164
65CDK80.78538756
66NME10.74815472
67EIF2AK30.74185011
68MET0.70803654
69MTOR0.70698924
70CDK60.70180549
71TESK10.69553982
72CDK10.69171038
73CLK10.65959394
74PAK10.64264907
75DAPK10.62952661
76MAP4K10.57361453
77FLT30.57254553
78PAK20.56604295
79CSNK2A20.56125157
80MELK0.52702250
81LRRK20.50978419
82PIM20.49414456
83TRPM70.48980453
84PDGFRA0.48013785
85ICK0.46717797
86TAOK20.46291721
87LATS20.46095320
88RAF10.45261765
89AKT20.44766567
90ZAK0.44099745
91KDR0.44083589
92TGFBR20.43758437
93CSNK1E0.43678295
94PIM10.43336485
95CSNK2A10.43235167
96MAPKAPK50.42702237
97CSNK1D0.41413640
98* PRKDC0.40644896
99NEK90.40542999
100BRAF0.38988246
101NME20.38750787
102TRIB30.38193321
103CDK90.38166105
104BCKDK0.36603429
105CAMKK10.35627645
106PRKCI0.35121697
107MAPK140.33645536
108CDK11A0.33597853
109RPS6KB10.31678726
110BTK0.31282167
111LMTK20.30535142
112MAP2K30.30146869
113CAMK1G0.30017784
114CDK140.29995573
115STK30.29802745
116CDK180.28413258
117CDK150.27607850
118RPS6KA50.27232635
119MAPK90.27104433
120RPS6KA10.27097996
121MAPK110.27029738
122TTN0.26655425
123KSR10.26484455
124MAPKAPK20.26112691
125RPS6KA20.26068099
126ILK0.26030866
127BMX0.25267717
128AKT10.24504982
129UHMK10.23874167
130GSK3B0.23662650

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92593025
2Mismatch repair_Homo sapiens_hsa034304.36374467
3* Spliceosome_Homo sapiens_hsa030403.52716507
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42115797
5RNA transport_Homo sapiens_hsa030133.21433300
6Base excision repair_Homo sapiens_hsa034103.11345976
7Cell cycle_Homo sapiens_hsa041102.87393053
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.86021638
9One carbon pool by folate_Homo sapiens_hsa006702.83584730
10Homologous recombination_Homo sapiens_hsa034402.79057035
11Nucleotide excision repair_Homo sapiens_hsa034202.68243130
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28833743
13mRNA surveillance pathway_Homo sapiens_hsa030152.28622040
14Ribosome_Homo sapiens_hsa030102.24250426
15Fanconi anemia pathway_Homo sapiens_hsa034602.21501703
16Proteasome_Homo sapiens_hsa030502.21197830
17Non-homologous end-joining_Homo sapiens_hsa034502.20481239
18RNA polymerase_Homo sapiens_hsa030202.14832814
19RNA degradation_Homo sapiens_hsa030181.90270407
20Pyrimidine metabolism_Homo sapiens_hsa002401.83578934
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81378424
22Basal transcription factors_Homo sapiens_hsa030221.67267512
23p53 signaling pathway_Homo sapiens_hsa041151.47484541
24Systemic lupus erythematosus_Homo sapiens_hsa053221.26081200
25Viral carcinogenesis_Homo sapiens_hsa052031.22983221
26Fatty acid elongation_Homo sapiens_hsa000621.20606585
27Basal cell carcinoma_Homo sapiens_hsa052171.19116864
28Oocyte meiosis_Homo sapiens_hsa041141.18515768
29Epstein-Barr virus infection_Homo sapiens_hsa051691.18398894
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16486796
31HTLV-I infection_Homo sapiens_hsa051661.14106319
32MicroRNAs in cancer_Homo sapiens_hsa052061.11816176
33Pyruvate metabolism_Homo sapiens_hsa006201.10590175
34Steroid biosynthesis_Homo sapiens_hsa001001.10390287
35Vitamin B6 metabolism_Homo sapiens_hsa007501.09377927
36Notch signaling pathway_Homo sapiens_hsa043301.07821292
37Sulfur relay system_Homo sapiens_hsa041221.04463391
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03420669
39Purine metabolism_Homo sapiens_hsa002301.00923669
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00675467
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00163141
42Galactose metabolism_Homo sapiens_hsa000520.99162110
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97271310
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97164675
45Colorectal cancer_Homo sapiens_hsa052100.93042311
46Other glycan degradation_Homo sapiens_hsa005110.91935702
47Small cell lung cancer_Homo sapiens_hsa052220.91225372
48Hippo signaling pathway_Homo sapiens_hsa043900.90521167
49Herpes simplex infection_Homo sapiens_hsa051680.89470436
50Antigen processing and presentation_Homo sapiens_hsa046120.87950634
51Hedgehog signaling pathway_Homo sapiens_hsa043400.87420528
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87184826
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82360982
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78384906
55Chronic myeloid leukemia_Homo sapiens_hsa052200.75536914
56Thyroid cancer_Homo sapiens_hsa052160.73394227
57Biosynthesis of amino acids_Homo sapiens_hsa012300.71729982
58Bladder cancer_Homo sapiens_hsa052190.68358203
59Alcoholism_Homo sapiens_hsa050340.68329695
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68061462
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.67524784
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66813666
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.66158715
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60578278
65Adherens junction_Homo sapiens_hsa045200.59846777
66Pathways in cancer_Homo sapiens_hsa052000.56613380
67Primary immunodeficiency_Homo sapiens_hsa053400.55160112
68Folate biosynthesis_Homo sapiens_hsa007900.53168550
69Glutathione metabolism_Homo sapiens_hsa004800.52619938
70Non-small cell lung cancer_Homo sapiens_hsa052230.52153502
71Viral myocarditis_Homo sapiens_hsa054160.52116960
72Selenocompound metabolism_Homo sapiens_hsa004500.51997446
73TGF-beta signaling pathway_Homo sapiens_hsa043500.51369640
74Apoptosis_Homo sapiens_hsa042100.51109576
75Arginine and proline metabolism_Homo sapiens_hsa003300.50103175
76Legionellosis_Homo sapiens_hsa051340.50064927
77Wnt signaling pathway_Homo sapiens_hsa043100.49544633
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48790495
79Hepatitis B_Homo sapiens_hsa051610.48134241
80Fatty acid metabolism_Homo sapiens_hsa012120.47957416
81HIF-1 signaling pathway_Homo sapiens_hsa040660.47110245
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46442465
83Shigellosis_Homo sapiens_hsa051310.46367075
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46299623
85Proteoglycans in cancer_Homo sapiens_hsa052050.43850021
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.43669542
87Endometrial cancer_Homo sapiens_hsa052130.42146380
88Measles_Homo sapiens_hsa051620.40201081
89Pentose phosphate pathway_Homo sapiens_hsa000300.38939573
90Lysine degradation_Homo sapiens_hsa003100.38858307
91Prostate cancer_Homo sapiens_hsa052150.38613004
92mTOR signaling pathway_Homo sapiens_hsa041500.37787137
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37112608
94Pancreatic cancer_Homo sapiens_hsa052120.36443248
95Melanoma_Homo sapiens_hsa052180.36361087
96Tight junction_Homo sapiens_hsa045300.36047166
97Acute myeloid leukemia_Homo sapiens_hsa052210.35863156
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.33235093
99T cell receptor signaling pathway_Homo sapiens_hsa046600.32086629
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.31046479
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30226094
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27648547
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.26910357
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26785291
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26762143
106Arginine biosynthesis_Homo sapiens_hsa002200.26469048
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25163723
108B cell receptor signaling pathway_Homo sapiens_hsa046620.24260927
109N-Glycan biosynthesis_Homo sapiens_hsa005100.24024783
110Metabolic pathways_Homo sapiens_hsa011000.22090264
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.21236616
112Focal adhesion_Homo sapiens_hsa045100.20896583
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19896179
114Influenza A_Homo sapiens_hsa051640.19663028
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19526600
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19266857
117Glioma_Homo sapiens_hsa052140.19109145
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18535672
119Prion diseases_Homo sapiens_hsa050200.16237491
120Carbon metabolism_Homo sapiens_hsa012000.15908474
121Fructose and mannose metabolism_Homo sapiens_hsa000510.15857478
122Dorso-ventral axis formation_Homo sapiens_hsa043200.15784288
123Fatty acid biosynthesis_Homo sapiens_hsa000610.14863602
124Hematopoietic cell lineage_Homo sapiens_hsa046400.14735925
125VEGF signaling pathway_Homo sapiens_hsa043700.14701500
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13173237
127Rap1 signaling pathway_Homo sapiens_hsa040150.12713427
128Renal cell carcinoma_Homo sapiens_hsa052110.12512962

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