Rank | Gene Set | Z-score |
---|---|---|
1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.36025844 |
2 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.65335675 |
3 | DNA replication initiation (GO:0006270) | 4.65166447 |
4 | nuclear pore organization (GO:0006999) | 4.63483218 |
5 | protein localization to kinetochore (GO:0034501) | 4.57832694 |
6 | proline biosynthetic process (GO:0006561) | 4.52039506 |
7 | DNA strand elongation (GO:0022616) | 4.43512511 |
8 | nuclear pore complex assembly (GO:0051292) | 4.41275281 |
9 | DNA strand renaturation (GO:0000733) | 4.19943852 |
10 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.19054939 |
11 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.19054939 |
12 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.13766828 |
13 | DNA topological change (GO:0006265) | 4.11177199 |
14 | mitotic nuclear envelope disassembly (GO:0007077) | 4.08092734 |
15 | IMP biosynthetic process (GO:0006188) | 4.02428361 |
16 | protein localization to chromosome, centromeric region (GO:0071459) | 3.94162146 |
17 | nucleobase biosynthetic process (GO:0046112) | 3.88655316 |
18 | nuclear envelope disassembly (GO:0051081) | 3.79915736 |
19 | membrane disassembly (GO:0030397) | 3.79915736 |
20 | COPI coating of Golgi vesicle (GO:0048205) | 3.77116135 |
21 | Golgi transport vesicle coating (GO:0048200) | 3.77116135 |
22 | formation of translation preinitiation complex (GO:0001731) | 3.76771527 |
23 | DNA duplex unwinding (GO:0032508) | 3.70790410 |
24 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.70222674 |
25 | DNA geometric change (GO:0032392) | 3.68978079 |
26 | telomere maintenance via recombination (GO:0000722) | 3.67655196 |
27 | mitotic sister chromatid segregation (GO:0000070) | 3.65359652 |
28 | DNA replication checkpoint (GO:0000076) | 3.62078757 |
29 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.61195322 |
30 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.61195322 |
31 | mitotic recombination (GO:0006312) | 3.61179165 |
32 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.61026309 |
33 | mitotic metaphase plate congression (GO:0007080) | 3.60353621 |
34 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.54741592 |
35 | kinetochore organization (GO:0051383) | 3.52025121 |
36 | regulation of helicase activity (GO:0051095) | 3.46784356 |
37 | telomere maintenance via telomere lengthening (GO:0010833) | 3.46596034 |
38 | sister chromatid segregation (GO:0000819) | 3.46500023 |
39 | mitotic chromosome condensation (GO:0007076) | 3.45864364 |
40 | chromosome condensation (GO:0030261) | 3.43214030 |
41 | heterochromatin organization (GO:0070828) | 3.43038185 |
42 | IMP metabolic process (GO:0046040) | 3.41040763 |
43 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.39356780 |
44 | establishment of integrated proviral latency (GO:0075713) | 3.38708067 |
45 | regulation of translational termination (GO:0006449) | 3.38533290 |
46 | folic acid metabolic process (GO:0046655) | 3.38344818 |
47 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.37672917 |
48 | regulation of gene silencing by miRNA (GO:0060964) | 3.37672917 |
49 | regulation of gene silencing by RNA (GO:0060966) | 3.37672917 |
50 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.37099521 |
51 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.36871843 |
52 | non-recombinational repair (GO:0000726) | 3.36871843 |
53 | protein complex localization (GO:0031503) | 3.36749900 |
54 | pore complex assembly (GO:0046931) | 3.36058663 |
55 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.34423770 |
56 | nuclear envelope reassembly (GO:0031468) | 3.33681317 |
57 | mitotic nuclear envelope reassembly (GO:0007084) | 3.33681317 |
58 | purine nucleobase biosynthetic process (GO:0009113) | 3.31774996 |
59 | regulation of histone H3-K9 methylation (GO:0051570) | 3.30575005 |
60 | establishment of viral latency (GO:0019043) | 3.29701413 |
61 | tRNA aminoacylation for protein translation (GO:0006418) | 3.29315535 |
62 | chromatin remodeling at centromere (GO:0031055) | 3.26661952 |
63 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.24226828 |
64 | regulation of mitotic spindle organization (GO:0060236) | 3.23115046 |
65 | metaphase plate congression (GO:0051310) | 3.23062281 |
66 | negative regulation of RNA splicing (GO:0033119) | 3.22731238 |
67 | pre-miRNA processing (GO:0031054) | 3.22556908 |
68 | tRNA aminoacylation (GO:0043039) | 3.22230088 |
69 | amino acid activation (GO:0043038) | 3.22230088 |
70 | negative regulation of histone methylation (GO:0031061) | 3.22114913 |
71 | ribosome biogenesis (GO:0042254) | 3.20183270 |
72 | maturation of SSU-rRNA (GO:0030490) | 3.18982547 |
73 | spliceosomal snRNP assembly (GO:0000387) | 3.16208688 |
74 | mitotic sister chromatid cohesion (GO:0007064) | 3.14764210 |
75 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.14528506 |
76 | CENP-A containing nucleosome assembly (GO:0034080) | 3.13817923 |
77 | positive regulation of chromosome segregation (GO:0051984) | 3.13568853 |
78 | negative regulation of chromosome segregation (GO:0051985) | 3.12907576 |
79 | histone H2A acetylation (GO:0043968) | 3.12646195 |
80 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.12190782 |
81 | proteasome assembly (GO:0043248) | 3.10424305 |
82 | negative regulation of mRNA processing (GO:0050686) | 3.10192419 |
83 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.09218480 |
84 | DNA replication-independent nucleosome organization (GO:0034724) | 3.09218480 |
85 | * RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.08852740 |
86 | * mRNA splicing, via spliceosome (GO:0000398) | 3.08852740 |
87 | spindle assembly checkpoint (GO:0071173) | 3.08009106 |
88 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.07885426 |
89 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.07885426 |
90 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.07885426 |
91 | negative regulation of sister chromatid segregation (GO:0033046) | 3.07885426 |
92 | kinetochore assembly (GO:0051382) | 3.07737804 |
93 | DNA ligation (GO:0006266) | 3.07570536 |
94 | regulation of chromosome segregation (GO:0051983) | 3.06853952 |
95 | mitotic spindle assembly checkpoint (GO:0007094) | 3.06715701 |
96 | * RNA splicing, via transesterification reactions (GO:0000375) | 3.06626013 |
97 | cellular protein complex localization (GO:0034629) | 3.04509618 |
98 | regulation of translational fidelity (GO:0006450) | 3.02866456 |
99 | histone arginine methylation (GO:0034969) | 3.02401122 |
100 | establishment of chromosome localization (GO:0051303) | 3.02187036 |
101 | spindle checkpoint (GO:0031577) | 3.02007594 |
102 | DNA packaging (GO:0006323) | 3.02004853 |
103 | ribosome assembly (GO:0042255) | 3.00242077 |
104 | DNA conformation change (GO:0071103) | 2.99883806 |
105 | regulation of spindle organization (GO:0090224) | 2.99013846 |
106 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.98933567 |
107 | peptidyl-arginine methylation (GO:0018216) | 2.98611073 |
108 | peptidyl-arginine N-methylation (GO:0035246) | 2.98611073 |
109 | chromosome segregation (GO:0007059) | 2.98133816 |
110 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.97610108 |
111 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.96880908 |
112 | mitotic spindle checkpoint (GO:0071174) | 2.95913349 |
113 | regulation of centrosome cycle (GO:0046605) | 2.95672597 |
114 | tRNA methylation (GO:0030488) | 2.95162859 |
115 | mismatch repair (GO:0006298) | 2.95151303 |
116 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.94121162 |
117 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.93897134 |
118 | chromatin assembly or disassembly (GO:0006333) | 2.93801576 |
119 | pentose-phosphate shunt (GO:0006098) | 2.93588071 |
120 | nuclear envelope organization (GO:0006998) | 2.92119309 |
121 | regulation of RNA export from nucleus (GO:0046831) | 2.91288709 |
122 | mRNA transport (GO:0051028) | 2.90714507 |
123 | chromatin assembly (GO:0031497) | 2.90230645 |
124 | peptidyl-lysine dimethylation (GO:0018027) | 2.89501373 |
125 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.89477179 |
126 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.88941519 |
127 | telomere organization (GO:0032200) | 2.88523842 |
128 | L-serine metabolic process (GO:0006563) | 2.88430125 |
129 | protein export from nucleus (GO:0006611) | 2.88241869 |
130 | regulation of sister chromatid cohesion (GO:0007063) | 2.87966862 |
131 | translesion synthesis (GO:0019985) | 2.87948767 |
132 | dosage compensation (GO:0007549) | 2.87891750 |
133 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.87619430 |
134 | protein localization to chromosome (GO:0034502) | 2.87413631 |
135 | regulation of DNA damage checkpoint (GO:2000001) | 2.87272589 |
136 | NADPH regeneration (GO:0006740) | 2.86198987 |
137 | viral mRNA export from host cell nucleus (GO:0046784) | 2.86016290 |
138 | ATP-dependent chromatin remodeling (GO:0043044) | 2.85975031 |
139 | telomere maintenance (GO:0000723) | 2.85818228 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.90031611 |
2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.10944902 |
3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.06102073 |
4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.53760177 |
5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.26325311 |
6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.13230277 |
7 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.78783870 |
8 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.68124703 |
9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.58529276 |
10 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.42972216 |
11 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.36044157 |
12 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35389822 |
13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.32750102 |
14 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.26514460 |
15 | MYC_22102868_ChIP-Seq_BL_Human | 2.25834779 |
16 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.25315252 |
17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.22614994 |
18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.15199456 |
19 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.12991138 |
20 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.11831562 |
21 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.09994911 |
22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.04633446 |
23 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.04373907 |
24 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.4358976 |
25 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.93162689 |
26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.91579439 |
27 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.87765442 |
28 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.86439626 |
29 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.81087857 |
30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.77502581 |
31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.74778004 |
32 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.74688542 |
33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.73567646 |
34 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.72854603 |
35 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.72293999 |
36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.71762181 |
37 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68974890 |
38 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.67981934 |
39 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.62179794 |
40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.59388692 |
41 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.56692766 |
42 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.56541868 |
43 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55553610 |
44 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.54440343 |
45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.49680942 |
46 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47030221 |
47 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.46723129 |
48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45023056 |
49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.41346392 |
50 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.40218032 |
51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.39501453 |
52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.38115173 |
53 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.34515291 |
54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.33529401 |
55 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.32555897 |
56 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.31184458 |
57 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.31104676 |
58 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.30071304 |
59 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.28062169 |
60 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.27957208 |
61 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27308677 |
62 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.24779321 |
63 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.22860779 |
64 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22784522 |
65 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.22165137 |
66 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.20456692 |
67 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.20435803 |
68 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.19067978 |
69 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.18215883 |
70 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.17596855 |
71 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.15632585 |
72 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.13884702 |
73 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.12196803 |
74 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.10210364 |
75 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.09726933 |
76 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.09655448 |
77 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09093605 |
78 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08344399 |
79 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.07038757 |
80 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.04353628 |
81 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.03879902 |
82 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.03879902 |
83 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.03879902 |
84 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.01950458 |
85 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01063185 |
86 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.99608398 |
87 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.99517436 |
88 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.98615392 |
89 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.97663816 |
90 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.96512458 |
91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95985688 |
92 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.95699956 |
93 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95634923 |
94 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.95521097 |
95 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.94498177 |
96 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.94436910 |
97 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.94077531 |
98 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.93579551 |
99 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93537532 |
100 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91149569 |
101 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.90684292 |
102 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.90622449 |
103 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.90377960 |
104 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.88488926 |
105 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.86189746 |
106 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.85881372 |
107 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.85121582 |
108 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.84571828 |
109 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83883856 |
110 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.83757293 |
111 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.83314643 |
112 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.83283395 |
113 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.82453070 |
114 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.82258918 |
115 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.81644952 |
116 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.81131178 |
117 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.81072289 |
118 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.80729761 |
119 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.80231154 |
120 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.79857454 |
121 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.78885067 |
122 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.78310128 |
123 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.78184509 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0010094_abnormal_chromosome_stability | 4.44394423 |
2 | MP0003111_abnormal_nucleus_morphology | 4.36685255 |
3 | MP0003693_abnormal_embryo_hatching | 4.24947877 |
4 | MP0004957_abnormal_blastocyst_morpholog | 3.84734159 |
5 | MP0003077_abnormal_cell_cycle | 3.73581310 |
6 | MP0008057_abnormal_DNA_replication | 3.47291429 |
7 | MP0008058_abnormal_DNA_repair | 2.99494909 |
8 | MP0002877_abnormal_melanocyte_morpholog | 2.79405747 |
9 | MP0008007_abnormal_cellular_replicative | 2.75114211 |
10 | MP0003123_paternal_imprinting | 2.55429663 |
11 | MP0008932_abnormal_embryonic_tissue | 2.51930215 |
12 | MP0010030_abnormal_orbit_morphology | 2.47588168 |
13 | MP0001730_embryonic_growth_arrest | 2.47520067 |
14 | MP0005451_abnormal_body_composition | 2.37281475 |
15 | MP0008877_abnormal_DNA_methylation | 2.34893373 |
16 | MP0000350_abnormal_cell_proliferation | 2.29228446 |
17 | MP0002396_abnormal_hematopoietic_system | 2.27257081 |
18 | MP0010352_gastrointestinal_tract_polyps | 2.16029603 |
19 | MP0003806_abnormal_nucleotide_metabolis | 2.06355486 |
20 | MP0003121_genomic_imprinting | 1.92349876 |
21 | MP0005380_embryogenesis_phenotype | 1.90063970 |
22 | MP0001672_abnormal_embryogenesis/_devel | 1.90063970 |
23 | MP0002085_abnormal_embryonic_tissue | 1.85727872 |
24 | MP0002653_abnormal_ependyma_morphology | 1.84889347 |
25 | MP0001697_abnormal_embryo_size | 1.83879774 |
26 | MP0010307_abnormal_tumor_latency | 1.82391787 |
27 | MP0004197_abnormal_fetal_growth/weight/ | 1.80068237 |
28 | MP0002084_abnormal_developmental_patter | 1.77946895 |
29 | MP0008260_abnormal_autophagy | 1.76533893 |
30 | MP0003984_embryonic_growth_retardation | 1.71231852 |
31 | MP0005076_abnormal_cell_differentiation | 1.68351321 |
32 | MP0002088_abnormal_embryonic_growth/wei | 1.68233289 |
33 | MP0002080_prenatal_lethality | 1.66844045 |
34 | MP0009697_abnormal_copulation | 1.65377913 |
35 | MP0003786_premature_aging | 1.59729855 |
36 | MP0000537_abnormal_urethra_morphology | 1.58608724 |
37 | MP0005058_abnormal_lysosome_morphology | 1.57296752 |
38 | MP0002086_abnormal_extraembryonic_tissu | 1.53502042 |
39 | MP0004808_abnormal_hematopoietic_stem | 1.52825965 |
40 | MP0000490_abnormal_crypts_of | 1.44557519 |
41 | MP0001293_anophthalmia | 1.43599475 |
42 | MP0003718_maternal_effect | 1.41012266 |
43 | MP0003119_abnormal_digestive_system | 1.39610430 |
44 | MP0000358_abnormal_cell_content/ | 1.38542091 |
45 | MP0000313_abnormal_cell_death | 1.37991399 |
46 | MP0000566_synostosis | 1.33162899 |
47 | MP0001661_extended_life_span | 1.32735385 |
48 | MP0004185_abnormal_adipocyte_glucose | 1.31951551 |
49 | MP0003890_abnormal_embryonic-extraembry | 1.30656782 |
50 | MP0003567_abnormal_fetal_cardiomyocyte | 1.25819610 |
51 | MP0002019_abnormal_tumor_incidence | 1.21199613 |
52 | MP0002009_preneoplasia | 1.17344165 |
53 | MP0002111_abnormal_tail_morphology | 1.16391634 |
54 | MP0009053_abnormal_anal_canal | 1.16329020 |
55 | MP0002210_abnormal_sex_determination | 1.15601438 |
56 | MP0000428_abnormal_craniofacial_morphol | 1.14616687 |
57 | MP0000703_abnormal_thymus_morphology | 1.13782363 |
58 | MP0004133_heterotaxia | 1.13156947 |
59 | MP0006035_abnormal_mitochondrial_morpho | 1.12552593 |
60 | MP0003937_abnormal_limbs/digits/tail_de | 1.11160914 |
61 | MP0002089_abnormal_postnatal_growth/wei | 1.10375970 |
62 | MP0009278_abnormal_bone_marrow | 1.09798813 |
63 | MP0003221_abnormal_cardiomyocyte_apopto | 1.05702320 |
64 | MP0006054_spinal_hemorrhage | 1.05449299 |
65 | MP0005501_abnormal_skin_physiology | 1.04972456 |
66 | MP0001915_intracranial_hemorrhage | 1.03339536 |
67 | MP0003861_abnormal_nervous_system | 1.00721919 |
68 | MP0005257_abnormal_intraocular_pressure | 1.00481828 |
69 | MP0002102_abnormal_ear_morphology | 0.99650737 |
70 | MP0010234_abnormal_vibrissa_follicle | 0.99293365 |
71 | MP0003315_abnormal_perineum_morphology | 0.99174089 |
72 | MP0003115_abnormal_respiratory_system | 0.99052356 |
73 | MP0000049_abnormal_middle_ear | 0.97571919 |
74 | MP0002166_altered_tumor_susceptibility | 0.93641807 |
75 | MP0001145_abnormal_male_reproductive | 0.92977520 |
76 | MP0003566_abnormal_cell_adhesion | 0.92946482 |
77 | MP0002092_abnormal_eye_morphology | 0.90524459 |
78 | MP0003941_abnormal_skin_development | 0.89009949 |
79 | MP0006292_abnormal_olfactory_placode | 0.88376644 |
80 | MP0002938_white_spotting | 0.87948759 |
81 | MP0004272_abnormal_basement_membrane | 0.85935670 |
82 | MP0002006_tumorigenesis | 0.83400623 |
83 | MP0003935_abnormal_craniofacial_develop | 0.83165581 |
84 | MP0000432_abnormal_head_morphology | 0.83005422 |
85 | MP0002398_abnormal_bone_marrow | 0.82663692 |
86 | MP0009703_decreased_birth_body | 0.82076540 |
87 | MP0003763_abnormal_thymus_physiology | 0.81407777 |
88 | MP0009672_abnormal_birth_weight | 0.80635157 |
89 | MP0001929_abnormal_gametogenesis | 0.80045438 |
90 | MP0001849_ear_inflammation | 0.79917571 |
91 | MP0001727_abnormal_embryo_implantation | 0.79558299 |
92 | MP0009333_abnormal_splenocyte_physiolog | 0.79113306 |
93 | MP0004233_abnormal_muscle_weight | 0.78621479 |
94 | MP0000678_abnormal_parathyroid_gland | 0.78581186 |
95 | MP0000733_abnormal_muscle_development | 0.78088394 |
96 | MP0001853_heart_inflammation | 0.78009171 |
97 | MP0002722_abnormal_immune_system | 0.77545425 |
98 | MP0005397_hematopoietic_system_phenotyp | 0.77225779 |
99 | MP0001545_abnormal_hematopoietic_system | 0.77225779 |
100 | MP0002249_abnormal_larynx_morphology | 0.76036507 |
101 | MP0003787_abnormal_imprinting | 0.75600314 |
102 | MP0001286_abnormal_eye_development | 0.75364423 |
103 | MP0004134_abnormal_chest_morphology | 0.74963395 |
104 | MP0002925_abnormal_cardiovascular_devel | 0.74814883 |
105 | MP0000653_abnormal_sex_gland | 0.74804047 |
106 | MP0002160_abnormal_reproductive_system | 0.74739545 |
107 | MP0003705_abnormal_hypodermis_morpholog | 0.74542814 |
108 | MP0001346_abnormal_lacrimal_gland | 0.73813368 |
109 | MP0002060_abnormal_skin_morphology | 0.73508967 |
110 | MP0002796_impaired_skin_barrier | 0.73352306 |
111 | MP0001216_abnormal_epidermal_layer | 0.72593740 |
112 | MP0003755_abnormal_palate_morphology | 0.72237928 |
113 | MP0005408_hypopigmentation | 0.71721469 |
114 | MP0002697_abnormal_eye_size | 0.70728710 |
115 | MP0005384_cellular_phenotype | 0.70438928 |
116 | MP0003122_maternal_imprinting | 0.70238701 |
117 | MP0000858_altered_metastatic_potential | 0.70023191 |
118 | MP0003453_abnormal_keratinocyte_physiol | 0.69706335 |
119 | MP0005623_abnormal_meninges_morphology | 0.68688333 |
120 | MP0003942_abnormal_urinary_system | 0.68412337 |
121 | MP0003283_abnormal_digestive_organ | 0.68102447 |
122 | MP0005621_abnormal_cell_physiology | 0.67565052 |
123 | MP0002269_muscular_atrophy | 0.66717707 |
124 | MP0008789_abnormal_olfactory_epithelium | 0.66023273 |
125 | MP0000689_abnormal_spleen_morphology | 0.65710321 |
126 | MP0003385_abnormal_body_wall | 0.65645579 |
127 | MP0002114_abnormal_axial_skeleton | 0.65477681 |
128 | MP0002116_abnormal_craniofacial_bone | 0.65177970 |
129 | MP0002932_abnormal_joint_morphology | 0.64885272 |
130 | MP0010630_abnormal_cardiac_muscle | 0.64868824 |
131 | MP0002075_abnormal_coat/hair_pigmentati | 0.64405070 |
132 | MP0003943_abnormal_hepatobiliary_system | 0.63961965 |
133 | MP0003656_abnormal_erythrocyte_physiolo | 0.60957440 |
134 | MP0001881_abnormal_mammary_gland | 0.59258802 |
135 | MP0001186_pigmentation_phenotype | 0.57985960 |
136 | MP0003950_abnormal_plasma_membrane | 0.56695188 |
137 | MP0000747_muscle_weakness | 0.56143248 |
138 | MP0000598_abnormal_liver_morphology | 0.55079193 |
139 | MP0005197_abnormal_uvea_morphology | 0.52284320 |
140 | MP0005464_abnormal_platelet_physiology | 0.51908755 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ependymoma (HP:0002888) | 4.27217337 |
2 | Microvesicular hepatic steatosis (HP:0001414) | 4.07943311 |
3 | Selective tooth agenesis (HP:0001592) | 3.89614954 |
4 | Medulloblastoma (HP:0002885) | 3.83885140 |
5 | Abnormality of glycolysis (HP:0004366) | 3.51303097 |
6 | Chromsome breakage (HP:0040012) | 3.45892048 |
7 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.43163118 |
8 | Birth length less than 3rd percentile (HP:0003561) | 3.29827673 |
9 | Increased nuchal translucency (HP:0010880) | 3.29134072 |
10 | Achilles tendon contracture (HP:0001771) | 3.26225187 |
11 | Colon cancer (HP:0003003) | 3.24865248 |
12 | Abnormal gallbladder physiology (HP:0012438) | 3.23605258 |
13 | Cholecystitis (HP:0001082) | 3.23605258 |
14 | Agnosia (HP:0010524) | 3.21700703 |
15 | Abnormal number of incisors (HP:0011064) | 3.20721008 |
16 | Astrocytoma (HP:0009592) | 3.18803418 |
17 | Abnormality of the astrocytes (HP:0100707) | 3.18803418 |
18 | Reticulocytopenia (HP:0001896) | 3.07926394 |
19 | Increased serum pyruvate (HP:0003542) | 3.02381205 |
20 | Progressive muscle weakness (HP:0003323) | 2.90726789 |
21 | Abnormality of the Achilles tendon (HP:0005109) | 2.90288957 |
22 | Patellar aplasia (HP:0006443) | 2.88069670 |
23 | Glioma (HP:0009733) | 2.85809023 |
24 | Overlapping toe (HP:0001845) | 2.85567824 |
25 | * Proximal placement of thumb (HP:0009623) | 2.80841432 |
26 | Cortical dysplasia (HP:0002539) | 2.80321625 |
27 | Abnormality of chromosome stability (HP:0003220) | 2.74596197 |
28 | Ragged-red muscle fibers (HP:0003200) | 2.73938025 |
29 | * Deviation of the thumb (HP:0009603) | 2.73919933 |
30 | Meckel diverticulum (HP:0002245) | 2.73688541 |
31 | Abnormality of the ileum (HP:0001549) | 2.72783509 |
32 | Absent radius (HP:0003974) | 2.69663043 |
33 | Rhabdomyosarcoma (HP:0002859) | 2.67424002 |
34 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.65964981 |
35 | Degeneration of anterior horn cells (HP:0002398) | 2.63332786 |
36 | Abnormality of the anterior horn cell (HP:0006802) | 2.63332786 |
37 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.61373917 |
38 | Short 4th metacarpal (HP:0010044) | 2.61373917 |
39 | Absent forearm bone (HP:0003953) | 2.61362757 |
40 | Aplasia involving forearm bones (HP:0009822) | 2.61362757 |
41 | High anterior hairline (HP:0009890) | 2.56167221 |
42 | Abnormality of the labia minora (HP:0012880) | 2.55327992 |
43 | Basal cell carcinoma (HP:0002671) | 2.50696287 |
44 | Abnormality of the preputium (HP:0100587) | 2.50623033 |
45 | Breast hypoplasia (HP:0003187) | 2.50087469 |
46 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.45725062 |
47 | Small intestinal stenosis (HP:0012848) | 2.44884530 |
48 | Duodenal stenosis (HP:0100867) | 2.44884530 |
49 | Ectopic kidney (HP:0000086) | 2.43998806 |
50 | Upper motor neuron abnormality (HP:0002127) | 2.42541034 |
51 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.39888193 |
52 | Volvulus (HP:0002580) | 2.38166546 |
53 | Neoplasm of striated muscle (HP:0009728) | 2.38135355 |
54 | 11 pairs of ribs (HP:0000878) | 2.36872420 |
55 | Amaurosis fugax (HP:0100576) | 2.36826287 |
56 | Progressive external ophthalmoplegia (HP:0000590) | 2.36144213 |
57 | Insomnia (HP:0100785) | 2.35782268 |
58 | Neoplasm of the pancreas (HP:0002894) | 2.33974735 |
59 | Abnormal lung lobation (HP:0002101) | 2.27248588 |
60 | Skull defect (HP:0001362) | 2.26009272 |
61 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.25878781 |
62 | Neoplasm of the oral cavity (HP:0100649) | 2.24677021 |
63 | Absent thumb (HP:0009777) | 2.23137582 |
64 | Abnormality of the carotid arteries (HP:0005344) | 2.22295232 |
65 | Spastic diplegia (HP:0001264) | 2.20711036 |
66 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.20083273 |
67 | Absent epiphyses (HP:0010577) | 2.20083273 |
68 | Multiple enchondromatosis (HP:0005701) | 2.18462724 |
69 | Myelodysplasia (HP:0002863) | 2.16826014 |
70 | Abnormality of oral frenula (HP:0000190) | 2.16323970 |
71 | Supernumerary spleens (HP:0009799) | 2.15526412 |
72 | Oral leukoplakia (HP:0002745) | 2.15234208 |
73 | Duplicated collecting system (HP:0000081) | 2.13024208 |
74 | Tracheoesophageal fistula (HP:0002575) | 2.11078537 |
75 | Ankyloglossia (HP:0010296) | 2.09090563 |
76 | Missing ribs (HP:0000921) | 2.08720289 |
77 | Elbow flexion contracture (HP:0002987) | 2.08500363 |
78 | Breech presentation (HP:0001623) | 2.07405767 |
79 | Secondary amenorrhea (HP:0000869) | 2.07087570 |
80 | Renal duplication (HP:0000075) | 2.06572608 |
81 | Orthostatic hypotension (HP:0001278) | 2.06232777 |
82 | Broad alveolar ridges (HP:0000187) | 2.05947690 |
83 | Broad distal phalanx of finger (HP:0009836) | 2.05798079 |
84 | Premature ovarian failure (HP:0008209) | 2.04229082 |
85 | Sloping forehead (HP:0000340) | 2.03788722 |
86 | Abnormality of the duodenum (HP:0002246) | 2.01986741 |
87 | Overriding aorta (HP:0002623) | 2.01823488 |
88 | Impulsivity (HP:0100710) | 2.01322129 |
89 | Premature graying of hair (HP:0002216) | 2.01205745 |
90 | Squamous cell carcinoma (HP:0002860) | 2.00584510 |
91 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.00133507 |
92 | Gastrointestinal carcinoma (HP:0002672) | 2.00133507 |
93 | Type I transferrin isoform profile (HP:0003642) | 1.98585396 |
94 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.97771312 |
95 | Carpal bone hypoplasia (HP:0001498) | 1.97322398 |
96 | Hyperacusis (HP:0010780) | 1.97081554 |
97 | High pitched voice (HP:0001620) | 1.97060441 |
98 | Cafe-au-lait spot (HP:0000957) | 1.96563941 |
99 | * Atresia of the external auditory canal (HP:0000413) | 1.94781290 |
100 | Horseshoe kidney (HP:0000085) | 1.94215480 |
101 | Abnormality of the umbilical cord (HP:0010881) | 1.92582193 |
102 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.92319529 |
103 | Ulnar bowing (HP:0003031) | 1.92110500 |
104 | Hypoplasia of the radius (HP:0002984) | 1.90529686 |
105 | Abnormality of reticulocytes (HP:0004312) | 1.90350101 |
106 | Short thumb (HP:0009778) | 1.90153387 |
107 | Abdominal situs inversus (HP:0003363) | 1.89953281 |
108 | Abnormality of abdominal situs (HP:0011620) | 1.89953281 |
109 | Asymmetry of the thorax (HP:0001555) | 1.89709349 |
110 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.89220753 |
111 | Cerebral hypomyelination (HP:0006808) | 1.88553708 |
112 | Rough bone trabeculation (HP:0100670) | 1.88254323 |
113 | Elfin facies (HP:0004428) | 1.84054993 |
114 | Triphalangeal thumb (HP:0001199) | 1.83348490 |
115 | Bone marrow hypocellularity (HP:0005528) | 1.83128731 |
116 | Prominent nose (HP:0000448) | 1.81889863 |
117 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.79354707 |
118 | Abnormal trabecular bone morphology (HP:0100671) | 1.79132333 |
119 | Embryonal renal neoplasm (HP:0011794) | 1.78757099 |
120 | Cholelithiasis (HP:0001081) | 1.78674720 |
121 | Duplication of thumb phalanx (HP:0009942) | 1.77823691 |
122 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.77742935 |
123 | Small epiphyses (HP:0010585) | 1.77697934 |
124 | Biliary tract neoplasm (HP:0100574) | 1.77690384 |
125 | Abnormality of the renal collecting system (HP:0004742) | 1.76833797 |
126 | Termporal pattern (HP:0011008) | 1.76694237 |
127 | Insidious onset (HP:0003587) | 1.76694237 |
128 | Glossoptosis (HP:0000162) | 1.75955633 |
129 | Cellular immunodeficiency (HP:0005374) | 1.75811353 |
130 | Abnormality of the salivary glands (HP:0010286) | 1.74874528 |
131 | Reticulocytosis (HP:0001923) | 1.74283052 |
132 | Pseudobulbar signs (HP:0002200) | 1.74178297 |
133 | Abnormal number of erythroid precursors (HP:0012131) | 1.73654733 |
134 | Abnormality of the calcaneus (HP:0008364) | 1.72654661 |
135 | Patellar dislocation (HP:0002999) | 1.72382853 |
136 | Cutis marmorata (HP:0000965) | 1.72174879 |
137 | Progressive hearing impairment (HP:0001730) | 1.71947294 |
138 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.70394479 |
139 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.68037885 |
140 | Septate vagina (HP:0001153) | 1.67574395 |
141 | Slender long bone (HP:0003100) | 1.66947308 |
142 | Long eyelashes (HP:0000527) | 1.66744520 |
143 | Abnormality of the incisor (HP:0000676) | 1.65698622 |
144 | Supernumerary ribs (HP:0005815) | 1.65636089 |
145 | Abnormality of the 4th metacarpal (HP:0010012) | 1.64729507 |
146 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.64702534 |
147 | Abnormal glycosylation (HP:0012345) | 1.64663628 |
148 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.64663628 |
149 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.64663628 |
150 | Abnormal protein glycosylation (HP:0012346) | 1.64663628 |
151 | * Trigonocephaly (HP:0000243) | 1.64014037 |
152 | Large eyes (HP:0001090) | 1.62440260 |
153 | * Trismus (HP:0000211) | 1.61764684 |
154 | Nonimmune hydrops fetalis (HP:0001790) | 1.60439712 |
155 | Upper limb muscle weakness (HP:0003484) | 1.60338874 |
156 | Premature rupture of membranes (HP:0001788) | 1.60249385 |
157 | * Choanal atresia (HP:0000453) | 1.59045190 |
158 | Cutaneous melanoma (HP:0012056) | 1.58534181 |
159 | Pancytopenia (HP:0001876) | 1.58279166 |
160 | Urethral obstruction (HP:0000796) | 1.57703433 |
161 | Reduced antithrombin III activity (HP:0001976) | 1.57059028 |
162 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.56554186 |
163 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.56554186 |
164 | Single umbilical artery (HP:0001195) | 1.56554186 |
165 | Entropion (HP:0000621) | 1.56506228 |
166 | * Deep philtrum (HP:0002002) | 1.56417341 |
167 | Hypergonadotropic hypogonadism (HP:0000815) | 1.55063960 |
168 | Microglossia (HP:0000171) | 1.54576352 |
169 | Poikiloderma (HP:0001029) | 1.54109535 |
170 | Abnormality of the fingertips (HP:0001211) | 1.52786424 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EEF2K | 5.03602491 |
2 | BUB1 | 4.27082087 |
3 | PASK | 4.27040405 |
4 | CDC7 | 4.24480450 |
5 | WEE1 | 3.37362882 |
6 | SMG1 | 2.90407627 |
7 | PBK | 2.58835397 |
8 | NEK2 | 2.57816170 |
9 | CDK12 | 2.55306631 |
10 | TSSK6 | 2.49790450 |
11 | RPS6KB2 | 2.42518611 |
12 | TTK | 2.23051088 |
13 | MAP3K10 | 2.22736275 |
14 | MAPKAPK3 | 2.17951908 |
15 | IRAK3 | 2.03539590 |
16 | SRPK1 | 2.01200336 |
17 | MKNK1 | 1.89570091 |
18 | NEK1 | 1.87225585 |
19 | VRK2 | 1.81214025 |
20 | EIF2AK1 | 1.79953203 |
21 | PLK1 | 1.73328065 |
22 | ATR | 1.70977309 |
23 | TESK2 | 1.69634238 |
24 | MST1R | 1.67987948 |
25 | CDK7 | 1.66103898 |
26 | PAK4 | 1.59968331 |
27 | CDK4 | 1.55523942 |
28 | PKN2 | 1.49884832 |
29 | SCYL2 | 1.46687746 |
30 | ACVR1B | 1.43521045 |
31 | CHEK1 | 1.42002410 |
32 | AURKB | 1.41412941 |
33 | BRSK2 | 1.41038417 |
34 | TLK1 | 1.37860756 |
35 | PLK3 | 1.37375108 |
36 | STK10 | 1.34981952 |
37 | TGFBR1 | 1.27237118 |
38 | BRD4 | 1.22630747 |
39 | MKNK2 | 1.22435101 |
40 | EPHA2 | 1.22227382 |
41 | CHEK2 | 1.20144512 |
42 | MAP3K8 | 1.19205256 |
43 | CCNB1 | 1.17086204 |
44 | BRSK1 | 1.17002912 |
45 | DYRK3 | 1.13785852 |
46 | ALK | 1.11841906 |
47 | AURKA | 1.10432178 |
48 | RPS6KA4 | 1.08058958 |
49 | VRK1 | 1.04922624 |
50 | PNCK | 0.95568609 |
51 | PRPF4B | 0.95001886 |
52 | EIF2AK2 | 0.93541946 |
53 | FGFR1 | 0.92467250 |
54 | PLK4 | 0.92338279 |
55 | CDK2 | 0.91974920 |
56 | ATM | 0.90952713 |
57 | PDK2 | 0.86007345 |
58 | STK16 | 0.83310789 |
59 | MOS | 0.82849838 |
60 | FGFR4 | 0.82500260 |
61 | PTK2 | 0.81959513 |
62 | ERBB4 | 0.81600302 |
63 | STK4 | 0.80925849 |
64 | TAF1 | 0.79362164 |
65 | CDK8 | 0.78538756 |
66 | NME1 | 0.74815472 |
67 | EIF2AK3 | 0.74185011 |
68 | MET | 0.70803654 |
69 | MTOR | 0.70698924 |
70 | CDK6 | 0.70180549 |
71 | TESK1 | 0.69553982 |
72 | CDK1 | 0.69171038 |
73 | CLK1 | 0.65959394 |
74 | PAK1 | 0.64264907 |
75 | DAPK1 | 0.62952661 |
76 | MAP4K1 | 0.57361453 |
77 | FLT3 | 0.57254553 |
78 | PAK2 | 0.56604295 |
79 | CSNK2A2 | 0.56125157 |
80 | MELK | 0.52702250 |
81 | LRRK2 | 0.50978419 |
82 | PIM2 | 0.49414456 |
83 | TRPM7 | 0.48980453 |
84 | PDGFRA | 0.48013785 |
85 | ICK | 0.46717797 |
86 | TAOK2 | 0.46291721 |
87 | LATS2 | 0.46095320 |
88 | RAF1 | 0.45261765 |
89 | AKT2 | 0.44766567 |
90 | ZAK | 0.44099745 |
91 | KDR | 0.44083589 |
92 | TGFBR2 | 0.43758437 |
93 | CSNK1E | 0.43678295 |
94 | PIM1 | 0.43336485 |
95 | CSNK2A1 | 0.43235167 |
96 | MAPKAPK5 | 0.42702237 |
97 | CSNK1D | 0.41413640 |
98 | * PRKDC | 0.40644896 |
99 | NEK9 | 0.40542999 |
100 | BRAF | 0.38988246 |
101 | NME2 | 0.38750787 |
102 | TRIB3 | 0.38193321 |
103 | CDK9 | 0.38166105 |
104 | BCKDK | 0.36603429 |
105 | CAMKK1 | 0.35627645 |
106 | PRKCI | 0.35121697 |
107 | MAPK14 | 0.33645536 |
108 | CDK11A | 0.33597853 |
109 | RPS6KB1 | 0.31678726 |
110 | BTK | 0.31282167 |
111 | LMTK2 | 0.30535142 |
112 | MAP2K3 | 0.30146869 |
113 | CAMK1G | 0.30017784 |
114 | CDK14 | 0.29995573 |
115 | STK3 | 0.29802745 |
116 | CDK18 | 0.28413258 |
117 | CDK15 | 0.27607850 |
118 | RPS6KA5 | 0.27232635 |
119 | MAPK9 | 0.27104433 |
120 | RPS6KA1 | 0.27097996 |
121 | MAPK11 | 0.27029738 |
122 | TTN | 0.26655425 |
123 | KSR1 | 0.26484455 |
124 | MAPKAPK2 | 0.26112691 |
125 | RPS6KA2 | 0.26068099 |
126 | ILK | 0.26030866 |
127 | BMX | 0.25267717 |
128 | AKT1 | 0.24504982 |
129 | UHMK1 | 0.23874167 |
130 | GSK3B | 0.23662650 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 4.92593025 |
2 | Mismatch repair_Homo sapiens_hsa03430 | 4.36374467 |
3 | * Spliceosome_Homo sapiens_hsa03040 | 3.52716507 |
4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.42115797 |
5 | RNA transport_Homo sapiens_hsa03013 | 3.21433300 |
6 | Base excision repair_Homo sapiens_hsa03410 | 3.11345976 |
7 | Cell cycle_Homo sapiens_hsa04110 | 2.87393053 |
8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.86021638 |
9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.83584730 |
10 | Homologous recombination_Homo sapiens_hsa03440 | 2.79057035 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.68243130 |
12 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.28833743 |
13 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.28622040 |
14 | Ribosome_Homo sapiens_hsa03010 | 2.24250426 |
15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.21501703 |
16 | Proteasome_Homo sapiens_hsa03050 | 2.21197830 |
17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.20481239 |
18 | RNA polymerase_Homo sapiens_hsa03020 | 2.14832814 |
19 | RNA degradation_Homo sapiens_hsa03018 | 1.90270407 |
20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.83578934 |
21 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.81378424 |
22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.67267512 |
23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.47484541 |
24 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.26081200 |
25 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.22983221 |
26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.20606585 |
27 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.19116864 |
28 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.18515768 |
29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.18398894 |
30 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.16486796 |
31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.14106319 |
32 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.11816176 |
33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.10590175 |
34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.10390287 |
35 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.09377927 |
36 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.07821292 |
37 | Sulfur relay system_Homo sapiens_hsa04122 | 1.04463391 |
38 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.03420669 |
39 | Purine metabolism_Homo sapiens_hsa00230 | 1.00923669 |
40 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.00675467 |
41 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.00163141 |
42 | Galactose metabolism_Homo sapiens_hsa00052 | 0.99162110 |
43 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.97271310 |
44 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.97164675 |
45 | Colorectal cancer_Homo sapiens_hsa05210 | 0.93042311 |
46 | Other glycan degradation_Homo sapiens_hsa00511 | 0.91935702 |
47 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.91225372 |
48 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.90521167 |
49 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.89470436 |
50 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.87950634 |
51 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.87420528 |
52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.87184826 |
53 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.82360982 |
54 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.78384906 |
55 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.75536914 |
56 | Thyroid cancer_Homo sapiens_hsa05216 | 0.73394227 |
57 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.71729982 |
58 | Bladder cancer_Homo sapiens_hsa05219 | 0.68358203 |
59 | Alcoholism_Homo sapiens_hsa05034 | 0.68329695 |
60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68061462 |
61 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.67524784 |
62 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.66813666 |
63 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.66158715 |
64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.60578278 |
65 | Adherens junction_Homo sapiens_hsa04520 | 0.59846777 |
66 | Pathways in cancer_Homo sapiens_hsa05200 | 0.56613380 |
67 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55160112 |
68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.53168550 |
69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.52619938 |
70 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.52153502 |
71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.52116960 |
72 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51997446 |
73 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.51369640 |
74 | Apoptosis_Homo sapiens_hsa04210 | 0.51109576 |
75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.50103175 |
76 | Legionellosis_Homo sapiens_hsa05134 | 0.50064927 |
77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.49544633 |
78 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.48790495 |
79 | Hepatitis B_Homo sapiens_hsa05161 | 0.48134241 |
80 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47957416 |
81 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.47110245 |
82 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.46442465 |
83 | Shigellosis_Homo sapiens_hsa05131 | 0.46367075 |
84 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.46299623 |
85 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.43850021 |
86 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.43669542 |
87 | Endometrial cancer_Homo sapiens_hsa05213 | 0.42146380 |
88 | Measles_Homo sapiens_hsa05162 | 0.40201081 |
89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.38939573 |
90 | Lysine degradation_Homo sapiens_hsa00310 | 0.38858307 |
91 | Prostate cancer_Homo sapiens_hsa05215 | 0.38613004 |
92 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.37787137 |
93 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.37112608 |
94 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.36443248 |
95 | Melanoma_Homo sapiens_hsa05218 | 0.36361087 |
96 | Tight junction_Homo sapiens_hsa04530 | 0.36047166 |
97 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.35863156 |
98 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.33235093 |
99 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.32086629 |
100 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.31046479 |
101 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.30226094 |
102 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.27648547 |
103 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.26910357 |
104 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.26785291 |
105 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.26762143 |
106 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.26469048 |
107 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.25163723 |
108 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.24260927 |
109 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24024783 |
110 | Metabolic pathways_Homo sapiens_hsa01100 | 0.22090264 |
111 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.21236616 |
112 | Focal adhesion_Homo sapiens_hsa04510 | 0.20896583 |
113 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.19896179 |
114 | Influenza A_Homo sapiens_hsa05164 | 0.19663028 |
115 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.19526600 |
116 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.19266857 |
117 | Glioma_Homo sapiens_hsa05214 | 0.19109145 |
118 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.18535672 |
119 | Prion diseases_Homo sapiens_hsa05020 | 0.16237491 |
120 | Carbon metabolism_Homo sapiens_hsa01200 | 0.15908474 |
121 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.15857478 |
122 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.15784288 |
123 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.14863602 |
124 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.14735925 |
125 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.14701500 |
126 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.13173237 |
127 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.12713427 |
128 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.12512962 |