ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	aggressive behavior (GO:0002118)	5.07999245
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.52984364
3	epithelial cilium movement (GO:0003351)	4.36653005
4	axoneme assembly (GO:0035082)	4.28754241
5	cilium movement (GO:0003341)	3.97530886
6	intraciliary transport (GO:0042073)	3.92712002
7	protein polyglutamylation (GO:0018095)	3.83419262
8	inositol phosphate catabolic process (GO:0071545)	3.69245575
9	regulation of cilium movement (GO:0003352)	3.68395704
10	behavioral response to nicotine (GO:0035095)	3.66411215
11	photoreceptor cell maintenance (GO:0045494)	3.65932011
12	retinal cone cell development (GO:0046549)	3.65332006
13	seminiferous tubule development (GO:0072520)	3.63434542
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.63296569
15	nonmotile primary cilium assembly (GO:0035058)	3.63138664
16	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.56892358
17	inositol phosphate dephosphorylation (GO:0046855)	3.56892358
18	cilium or flagellum-dependent cell motility (GO:0001539)	3.56296021
19	respiratory chain complex IV assembly (GO:0008535)	3.44666210
20	cellular ketone body metabolic process (GO:0046950)	3.40011197
21	cytochrome complex assembly (GO:0017004)	3.39134589
22	retinal ganglion cell axon guidance (GO:0031290)	3.38781544
23	parental behavior (GO:0060746)	3.37005767
24	protein complex biogenesis (GO:0070271)	3.36366364
25	protein localization to cilium (GO:0061512)	3.33082130
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.30791144
27	maternal behavior (GO:0042711)	3.30368550
28	nucleobase catabolic process (GO:0046113)	3.30203655
29	behavioral response to ethanol (GO:0048149)	3.29190049
30	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.19993733
31	response to pheromone (GO:0019236)	3.15336058
32	cilium organization (GO:0044782)	3.08466047
33	presynaptic membrane organization (GO:0097090)	3.04804719
34	cilium morphogenesis (GO:0060271)	3.04799875
35	retinal rod cell development (GO:0046548)	3.02808957
36	kidney morphogenesis (GO:0060993)	3.02671588
37	ketone body metabolic process (GO:1902224)	3.01222884
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.00232924
39	cilium assembly (GO:0042384)	2.96529876
40	interkinetic nuclear migration (GO:0022027)	2.94207000
41	estrogen biosynthetic process (GO:0006703)	2.86829265
42	neuronal action potential (GO:0019228)	2.84723890
43	presynaptic membrane assembly (GO:0097105)	2.84264158
44	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.82648610
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.82391723
46	GPI anchor metabolic process (GO:0006505)	2.81107407
47	axonemal dynein complex assembly (GO:0070286)	2.78716898
48	positive regulation of histone H3-K4 methylation (GO:0051571)	2.78347355
49	polyol catabolic process (GO:0046174)	2.75600606
50	dendritic spine morphogenesis (GO:0060997)	2.72177831
51	regulation of female receptivity (GO:0045924)	2.71557421
52	nephron tubule morphogenesis (GO:0072078)	2.69849023
53	nephron epithelium morphogenesis (GO:0072088)	2.69849023
54	neural tube formation (GO:0001841)	2.67050689
55	positive regulation of amino acid transport (GO:0051957)	2.66407150
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.66260902
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.66260902
58	NADH dehydrogenase complex assembly (GO:0010257)	2.66260902
59	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.64879879
60	dentate gyrus development (GO:0021542)	2.64072958
61	brain morphogenesis (GO:0048854)	2.63331790
62	indolalkylamine metabolic process (GO:0006586)	2.63303564
63	fucose catabolic process (GO:0019317)	2.62616312
64	L-fucose metabolic process (GO:0042354)	2.62616312
65	L-fucose catabolic process (GO:0042355)	2.62616312
66	positive regulation of meiosis (GO:0045836)	2.60774497
67	branched-chain amino acid catabolic process (GO:0009083)	2.59452765
68	pancreas development (GO:0031016)	2.55937490
69	positive regulation of prostaglandin secretion (GO:0032308)	2.53870829
70	indole-containing compound catabolic process (GO:0042436)	2.53029080
71	indolalkylamine catabolic process (GO:0046218)	2.53029080
72	tryptophan catabolic process (GO:0006569)	2.53029080
73	positive regulation of amine transport (GO:0051954)	2.52835869
74	C-terminal protein lipidation (GO:0006501)	2.52419572
75	photoreceptor cell development (GO:0042461)	2.52331627
76	cell wall macromolecule catabolic process (GO:0016998)	2.51665873
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51101428
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.50731110
79	glycerophospholipid catabolic process (GO:0046475)	2.48819042
80	S-adenosylmethionine metabolic process (GO:0046500)	2.48157679
81	regulation of neurotransmitter uptake (GO:0051580)	2.45581034
82	mannosylation (GO:0097502)	2.45473327
83	auditory receptor cell differentiation (GO:0042491)	2.45221776
84	regulation of hexokinase activity (GO:1903299)	2.43764793
85	regulation of glucokinase activity (GO:0033131)	2.43764793
86	platelet dense granule organization (GO:0060155)	2.43527455
87	cellular component assembly involved in morphogenesis (GO:0010927)	2.40361395
88	positive regulation of meiotic cell cycle (GO:0051446)	2.39995101
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.39165357
90	detection of light stimulus involved in visual perception (GO:0050908)	2.39165357
91	nitric oxide mediated signal transduction (GO:0007263)	2.38202699
92	determination of left/right symmetry (GO:0007368)	2.37871576
93	response to nitrosative stress (GO:0051409)	2.37180647
94	positive regulation of organic acid transport (GO:0032892)	2.37091315
95	renal tubule morphogenesis (GO:0061333)	2.34471497
96	GPI anchor biosynthetic process (GO:0006506)	2.33549672
97	inner ear receptor stereocilium organization (GO:0060122)	2.33416003
98	signal peptide processing (GO:0006465)	2.32238290
99	axonal fasciculation (GO:0007413)	2.31198183
100	valine metabolic process (GO:0006573)	2.30619551

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.49901437
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.29698966
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.96744869
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79120585
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64360821
6	VDR_22108803_ChIP-Seq_LS180_Human	2.64136812
7	FUS_26573619_Chip-Seq_HEK293_Human	2.63403549
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61585316
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61523840
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.59541949
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48268873
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.41884541
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27808200
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23787891
15	EWS_26573619_Chip-Seq_HEK293_Human	2.16423596
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10151700
17	P300_19829295_ChIP-Seq_ESCs_Human	2.07901286
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06054791
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05089642
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84553535
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84429505
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82434016
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79940743
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77078425
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76169739
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.74358986
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74066911
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.72506644
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67249089
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.64223043
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.63840602
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62892795
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61719668
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.58454324
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56216112
36	STAT3_23295773_ChIP-Seq_U87_Human	1.54759265
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.53967962
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51949098
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49786677
40	AR_25329375_ChIP-Seq_VCAP_Human	1.48097833
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47674355
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46687952
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.46599512
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45494645
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42939600
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42403713
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.42403713
48	TCF4_23295773_ChIP-Seq_U87_Human	1.41733046
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39833664
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39695972
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39124619
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37983821
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35814975
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35264509
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.33025115
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.32484801
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31943319
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30482710
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29946115
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27275289
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27005923
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26992345
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26992345
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22256805
65	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21984170
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21081004
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21081004
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.20919210
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20754577
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20492061
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18495345
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17488384
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17177357
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16159409
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13235093
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11892473
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10964888
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.09844018
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09486121
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09244962
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09133735
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09024771
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08969749
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08969749
85	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.08877887
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08572073
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05122878
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04826761
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04607515
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03178042
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02172732
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00858285
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.99909670
94	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99731863
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99417381
96	AR_20517297_ChIP-Seq_VCAP_Human	0.99046204
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96288127
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.95614353
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95380568
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95317888

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.27191034
2	MP0002837_dystrophic_cardiac_calcinosis	2.94734834
3	MP0006072_abnormal_retinal_apoptosis	2.77473759
4	MP0005645_abnormal_hypothalamus_physiol	2.71107117
5	MP0005646_abnormal_pituitary_gland	2.53629157
6	MP0003880_abnormal_central_pattern	2.52463527
7	MP0006292_abnormal_olfactory_placode	2.46059565
8	MP0005551_abnormal_eye_electrophysiolog	2.45165110
9	MP0008877_abnormal_DNA_methylation	2.45110206
10	MP0005379_endocrine/exocrine_gland_phen	2.38858589
11	MP0005253_abnormal_eye_physiology	2.21702420
12	MP0002102_abnormal_ear_morphology	2.11511574
13	MP0003122_maternal_imprinting	2.04444174
14	MP0000631_abnormal_neuroendocrine_gland	2.02654642
15	MP0004133_heterotaxia	1.96327661
16	MP0005084_abnormal_gallbladder_morpholo	1.92689023
17	MP0001984_abnormal_olfaction	1.90831912
18	MP0001968_abnormal_touch/_nociception	1.90452659
19	MP0002638_abnormal_pupillary_reflex	1.88441202
20	MP0006276_abnormal_autonomic_nervous	1.83779747
21	MP0002938_white_spotting	1.79491943
22	MP0003121_genomic_imprinting	1.76688643
23	MP0002822_catalepsy	1.76481675
24	MP0002163_abnormal_gland_morphology	1.72507722
25	MP0009046_muscle_twitch	1.69783271
26	MP0000372_irregular_coat_pigmentation	1.64260048
27	MP0001529_abnormal_vocalization	1.63192028
28	MP0004145_abnormal_muscle_electrophysio	1.58588512
29	MP0002928_abnormal_bile_duct	1.56480963
30	MP0003011_delayed_dark_adaptation	1.56240015
31	MP0005423_abnormal_somatic_nervous	1.54860798
32	MP0002909_abnormal_adrenal_gland	1.53798098
33	MP0002557_abnormal_social/conspecific_i	1.52099244
34	MP0002272_abnormal_nervous_system	1.51765601
35	MP0009745_abnormal_behavioral_response	1.50990318
36	MP0002572_abnormal_emotion/affect_behav	1.48808515
37	MP0004885_abnormal_endolymph	1.46414015
38	MP0001486_abnormal_startle_reflex	1.44046332
39	MP0004270_analgesia	1.43655034
40	MP0002736_abnormal_nociception_after	1.43602211
41	MP0001501_abnormal_sleep_pattern	1.42372307
42	MP0004142_abnormal_muscle_tone	1.37189225
43	MP0000383_abnormal_hair_follicle	1.34125158
44	MP0002735_abnormal_chemical_nociception	1.32514349
45	MP0002734_abnormal_mechanical_nocicepti	1.31749715
46	MP0000569_abnormal_digit_pigmentation	1.31139197
47	MP0001970_abnormal_pain_threshold	1.23414940
48	MP0008058_abnormal_DNA_repair	1.23008109
49	MP0005367_renal/urinary_system_phenotyp	1.21277940
50	MP0000516_abnormal_urinary_system	1.21277940
51	MP0002234_abnormal_pharynx_morphology	1.21147517
52	MP0000427_abnormal_hair_cycle	1.20913574
53	MP0005248_abnormal_Harderian_gland	1.20844454
54	MP0005195_abnormal_posterior_eye	1.16500514
55	MP0000778_abnormal_nervous_system	1.16259061
56	MP0004043_abnormal_pH_regulation	1.13210152
57	MP0002064_seizures	1.11985854
58	MP0001944_abnormal_pancreas_morphology	1.10607451
59	MP0002063_abnormal_learning/memory/cond	1.07510755
60	MP0005174_abnormal_tail_pigmentation	1.07316276
61	MP0002876_abnormal_thyroid_physiology	1.06043130
62	MP0005386_behavior/neurological_phenoty	1.05711021
63	MP0004924_abnormal_behavior	1.05711021
64	MP0003195_calcinosis	1.03488293
65	MP0008789_abnormal_olfactory_epithelium	1.03293478
66	MP0001188_hyperpigmentation	1.03051690
67	MP0002693_abnormal_pancreas_physiology	1.01796579
68	MP0002653_abnormal_ependyma_morphology	1.01765446
69	MP0002184_abnormal_innervation	1.01548331
70	MP0001905_abnormal_dopamine_level	1.00418856
71	MP0005220_abnormal_exocrine_pancreas	0.99558755
72	MP0002733_abnormal_thermal_nociception	0.98898377
73	MP0001986_abnormal_taste_sensitivity	0.97837385
74	MP0003635_abnormal_synaptic_transmissio	0.96717119
75	MP0008875_abnormal_xenobiotic_pharmacok	0.96637644
76	MP0008872_abnormal_physiological_respon	0.96003184
77	MP0010386_abnormal_urinary_bladder	0.94532775
78	MP0002067_abnormal_sensory_capabilities	0.93278795
79	MP0004742_abnormal_vestibular_system	0.92841783
80	MP0005391_vision/eye_phenotype	0.92317009
81	MP0004215_abnormal_myocardial_fiber	0.91620455
82	MP0000013_abnormal_adipose_tissue	0.90494166
83	MP0010678_abnormal_skin_adnexa	0.90230344
84	MP0003136_yellow_coat_color	0.90229100
85	MP0002752_abnormal_somatic_nervous	0.88797379
86	MP0003718_maternal_effect	0.87342229
87	MP0002229_neurodegeneration	0.87122823
88	MP0003633_abnormal_nervous_system	0.86606173
89	MP0002095_abnormal_skin_pigmentation	0.86294084
90	MP0002160_abnormal_reproductive_system	0.84831842
91	MP0001485_abnormal_pinna_reflex	0.84478616
92	MP0005499_abnormal_olfactory_system	0.83922207
93	MP0005394_taste/olfaction_phenotype	0.83922207
94	MP0005389_reproductive_system_phenotype	0.83811864
95	MP0000566_synostosis	0.80853581
96	MP0003137_abnormal_impulse_conducting	0.80641152
97	MP0002882_abnormal_neuron_morphology	0.80062973
98	MP0000647_abnormal_sebaceous_gland	0.77562610
99	MP0001324_abnormal_eye_pigmentation	0.76847745
100	MP0001963_abnormal_hearing_physiology	0.76425681

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.00886778
2	Pancreatic fibrosis (HP:0100732)	3.72364874
3	Molar tooth sign on MRI (HP:0002419)	3.62307514
4	Abnormality of midbrain morphology (HP:0002418)	3.62307514
5	Pancreatic cysts (HP:0001737)	3.60980795
6	True hermaphroditism (HP:0010459)	3.47786998
7	Nephronophthisis (HP:0000090)	3.47245634
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.44150319
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.33672691
10	Gait imbalance (HP:0002141)	3.28900055
11	Absent/shortened dynein arms (HP:0200106)	3.22012118
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.22012118
13	Congenital primary aphakia (HP:0007707)	3.20685271
14	Abnormality of the renal medulla (HP:0100957)	3.10492708
15	Abnormal respiratory epithelium morphology (HP:0012253)	3.00204932
16	Abnormal respiratory motile cilium morphology (HP:0005938)	3.00204932
17	Nephrogenic diabetes insipidus (HP:0009806)	2.96827340
18	Type II lissencephaly (HP:0007260)	2.95472704
19	Intestinal atresia (HP:0011100)	2.94230237
20	Abnormal ciliary motility (HP:0012262)	2.93868420
21	Tubulointerstitial nephritis (HP:0001970)	2.92766697
22	Attenuation of retinal blood vessels (HP:0007843)	2.89870104
23	Abnormality of the renal cortex (HP:0011035)	2.88444170
24	Genital tract atresia (HP:0001827)	2.86575764
25	Congenital stationary night blindness (HP:0007642)	2.79352799
26	Vaginal atresia (HP:0000148)	2.78999993
27	Chronic hepatic failure (HP:0100626)	2.75030159
28	Decreased circulating renin level (HP:0003351)	2.72783445
29	Abolished electroretinogram (ERG) (HP:0000550)	2.70241388
30	Hemiparesis (HP:0001269)	2.57917014
31	Pendular nystagmus (HP:0012043)	2.56380346
32	Congenital malformation of the right heart (HP:0011723)	2.50371070
33	Double outlet right ventricle (HP:0001719)	2.50371070
34	Hypothermia (HP:0002045)	2.45184197
35	Methylmalonic acidemia (HP:0002912)	2.43816732
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43239231
37	Acute necrotizing encephalopathy (HP:0006965)	2.43144196
38	Cystic liver disease (HP:0006706)	2.42924897
39	Renal cortical cysts (HP:0000803)	2.42673562
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.39399595
41	Mitochondrial inheritance (HP:0001427)	2.35958524
42	Cerebellar dysplasia (HP:0007033)	2.35397895
43	Decreased central vision (HP:0007663)	2.33985411
44	Progressive macrocephaly (HP:0004481)	2.29756756
45	Hyperventilation (HP:0002883)	2.25961504
46	Lissencephaly (HP:0001339)	2.25563598
47	Hyperglycinemia (HP:0002154)	2.25143458
48	Febrile seizures (HP:0002373)	2.21423586
49	Abnormal drinking behavior (HP:0030082)	2.14206807
50	Polydipsia (HP:0001959)	2.14206807
51	Abnormality of vitamin B metabolism (HP:0004340)	2.12512450
52	Methylmalonic aciduria (HP:0012120)	2.11707088
53	Congenital hepatic fibrosis (HP:0002612)	2.08541854
54	Increased CSF lactate (HP:0002490)	2.08525126
55	3-Methylglutaconic aciduria (HP:0003535)	2.08401142
56	Ketoacidosis (HP:0001993)	2.07759885
57	Poor coordination (HP:0002370)	2.07752644
58	Keratoconus (HP:0000563)	2.05473567
59	Increased corneal curvature (HP:0100692)	2.05473567
60	Tubular atrophy (HP:0000092)	2.05303325
61	Gaze-evoked nystagmus (HP:0000640)	2.02838972
62	Acute encephalopathy (HP:0006846)	2.01735459
63	Abnormal mitochondria in muscle tissue (HP:0008316)	2.00909699
64	Colon cancer (HP:0003003)	2.00369974
65	Hepatocellular necrosis (HP:0001404)	1.99162282
66	Postaxial hand polydactyly (HP:0001162)	1.99076168
67	Hyperkalemia (HP:0002153)	1.97122905
68	Anencephaly (HP:0002323)	1.96927197
69	Focal motor seizures (HP:0011153)	1.94439795
70	Lipid accumulation in hepatocytes (HP:0006561)	1.91850878
71	Oligodactyly (hands) (HP:0001180)	1.91124562
72	Ketosis (HP:0001946)	1.90988335
73	Bile duct proliferation (HP:0001408)	1.90239785
74	Abnormal biliary tract physiology (HP:0012439)	1.90239785
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90157793
76	Increased hepatocellular lipid droplets (HP:0006565)	1.89029021
77	Optic disc pallor (HP:0000543)	1.87815013
78	Tubulointerstitial abnormality (HP:0001969)	1.87252292
79	Progressive cerebellar ataxia (HP:0002073)	1.87213464
80	Polyphagia (HP:0002591)	1.86914911
81	Postaxial foot polydactyly (HP:0001830)	1.86332768
82	Hepatic necrosis (HP:0002605)	1.85919709
83	Hyperglycinuria (HP:0003108)	1.85717896
84	Abnormality of the labia minora (HP:0012880)	1.85020161
85	Neoplasm of the adrenal cortex (HP:0100641)	1.83992803
86	Retinitis pigmentosa (HP:0000510)	1.82604088
87	Concave nail (HP:0001598)	1.82490507
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80664837
89	Agitation (HP:0000713)	1.80627299
90	Abdominal situs inversus (HP:0003363)	1.80178098
91	Abnormality of abdominal situs (HP:0011620)	1.80178098
92	Limb dystonia (HP:0002451)	1.79361234
93	Male pseudohermaphroditism (HP:0000037)	1.78615346
94	Sclerocornea (HP:0000647)	1.77789764
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76038120
96	Large for gestational age (HP:0001520)	1.75086762
97	Renal Fanconi syndrome (HP:0001994)	1.74410605
98	Optic nerve hypoplasia (HP:0000609)	1.73766533
99	Retinal dysplasia (HP:0007973)	1.73203214
100	Rhinitis (HP:0012384)	1.70632460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.18321554
2	MAP4K2	3.40254431
3	WNK3	3.13340455
4	CASK	2.95031653
5	MAP3K4	2.85509231
6	PINK1	2.59239936
7	ZAK	2.45589913
8	TAOK3	2.40846236
9	NUAK1	2.39950412
10	TNIK	2.34485791
11	BCKDK	2.32996517
12	BMPR1B	2.07447870
13	MAPK13	2.06404364
14	GRK1	2.05049761
15	ADRBK2	1.98914359
16	MARK1	1.86254708
17	INSRR	1.85119122
18	MAP2K7	1.85112633
19	FGFR2	1.74090441
20	PNCK	1.63206479
21	BRSK2	1.45237570
22	DAPK2	1.41850128
23	FLT3	1.36335349
24	MKNK2	1.29849318
25	TIE1	1.26049572
26	MAP2K6	1.24633046
27	WNK4	1.24126129
28	CSNK1G2	1.22298871
29	DYRK2	1.21865185
30	ACVR1B	1.17532413
31	PHKG2	1.13398991
32	PHKG1	1.13398991
33	STK38L	1.11110916
34	TLK1	1.10427858
35	OBSCN	1.08756248
36	CSNK1G1	1.07562799
37	PAK3	1.02196877
38	CSNK1G3	1.00756080
39	PRKCG	1.00054308
40	PRKCE	0.98137764
41	NTRK3	0.96725057
42	BCR	0.95491861
43	EPHA3	0.91288887
44	VRK1	0.88679574
45	EPHA4	0.87275672
46	WEE1	0.87228201
47	CSNK1A1L	0.84841864
48	VRK2	0.84432537
49	MKNK1	0.81450128
50	STK39	0.78183187
51	UHMK1	0.74917288
52	MAP2K4	0.72599838
53	OXSR1	0.71466183
54	ERBB3	0.70856226
55	PLK2	0.69174934
56	STK24	0.68126465
57	NTRK2	0.67095403
58	NLK	0.62795206
59	ADRBK1	0.61742850
60	CAMK2A	0.61250451
61	TRIM28	0.59513572
62	MAPK15	0.58249094
63	PRKCQ	0.57606274
64	MAP3K7	0.57456817
65	AKT3	0.57296666
66	DYRK1A	0.56754215
67	CAMK1	0.56057992
68	PRKACA	0.55321348
69	PKN1	0.54327647
70	STK3	0.52950577
71	CAMK2D	0.51294767
72	PLK3	0.49993366
73	RPS6KA5	0.48803230
74	DYRK3	0.48585873
75	FER	0.47861212
76	CSNK1A1	0.45852575
77	TNK2	0.45721085
78	KIT	0.44833141
79	STK11	0.43501271
80	CDK3	0.43495977
81	TGFBR1	0.40913118
82	GRK7	0.40667931
83	TEC	0.39701379
84	MINK1	0.39478127
85	PRKG1	0.38832975
86	MST4	0.38122301
87	PRKACB	0.37905972
88	PRKAA1	0.37591347
89	ATM	0.36864845
90	SGK2	0.36217372
91	PIK3CA	0.35506160
92	PRKCA	0.34876643
93	CSNK1D	0.34771093
94	TXK	0.34645905
95	PLK1	0.33888228
96	CDK5	0.33516902
97	PTK2B	0.32288608
98	PLK4	0.32067370
99	TAF1	0.31315673
100	MAPKAPK5	0.30660707

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.35770079
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.28756672
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.98718733
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58309647
5	Butanoate metabolism_Homo sapiens_hsa00650	2.58116524
6	Phototransduction_Homo sapiens_hsa04744	2.41871458
7	Protein export_Homo sapiens_hsa03060	2.17352736
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.16368468
9	Propanoate metabolism_Homo sapiens_hsa00640	2.01484692
10	Parkinsons disease_Homo sapiens_hsa05012	1.88416056
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84112554
12	Nicotine addiction_Homo sapiens_hsa05033	1.83690831
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82972327
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80361515
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.78491332
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.72436162
17	Taste transduction_Homo sapiens_hsa04742	1.69689126
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68620413
19	Peroxisome_Homo sapiens_hsa04146	1.57321137
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.56790242
21	Insulin secretion_Homo sapiens_hsa04911	1.55462768
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50495718
23	Circadian entrainment_Homo sapiens_hsa04713	1.49314925
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48152508
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.47677315
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45733669
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.41499946
28	Huntingtons disease_Homo sapiens_hsa05016	1.33519369
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.32330538
30	Olfactory transduction_Homo sapiens_hsa04740	1.26431665
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.21940797
32	Alzheimers disease_Homo sapiens_hsa05010	1.21807734
33	Regulation of autophagy_Homo sapiens_hsa04140	1.19316407
34	Morphine addiction_Homo sapiens_hsa05032	1.18697676
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.17536933
36	Homologous recombination_Homo sapiens_hsa03440	1.13763633
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12568549
38	Basal transcription factors_Homo sapiens_hsa03022	1.11966774
39	Serotonergic synapse_Homo sapiens_hsa04726	1.10979868
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08913644
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.08073997
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07600524
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05299193
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00760601
45	Sulfur metabolism_Homo sapiens_hsa00920	0.99049295
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98855129
47	Salivary secretion_Homo sapiens_hsa04970	0.98781640
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.98574833
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98420796
50	GABAergic synapse_Homo sapiens_hsa04727	0.98264489
51	Fatty acid elongation_Homo sapiens_hsa00062	0.97461439
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97418441
53	ABC transporters_Homo sapiens_hsa02010	0.97098731
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96910462
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95437233
56	RNA degradation_Homo sapiens_hsa03018	0.95133030
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91304790
58	Retinol metabolism_Homo sapiens_hsa00830	0.90160617
59	Renin secretion_Homo sapiens_hsa04924	0.89713755
60	Long-term depression_Homo sapiens_hsa04730	0.88680754
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87803554
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87214441
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86757455
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.86664707
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84987357
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.80516648
67	RNA polymerase_Homo sapiens_hsa03020	0.78079681
68	Metabolic pathways_Homo sapiens_hsa01100	0.77170961
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76379492
70	Purine metabolism_Homo sapiens_hsa00230	0.76315338
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73655335
72	Amphetamine addiction_Homo sapiens_hsa05031	0.71561445
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70571241
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69392837
75	Cocaine addiction_Homo sapiens_hsa05030	0.68955754
76	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68117053
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.68064531
78	Circadian rhythm_Homo sapiens_hsa04710	0.67804422
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64938560
80	Glutathione metabolism_Homo sapiens_hsa00480	0.62269786
81	Folate biosynthesis_Homo sapiens_hsa00790	0.56794964
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53182688
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51496394
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51071578
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.49068361
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48582455
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.44678497
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.40344582
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38611089
90	Caffeine metabolism_Homo sapiens_hsa00232	0.38463677
91	Mineral absorption_Homo sapiens_hsa04978	0.38402050
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38080057
93	One carbon pool by folate_Homo sapiens_hsa00670	0.37828161
94	Cholinergic synapse_Homo sapiens_hsa04725	0.37092355
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35166805
96	Asthma_Homo sapiens_hsa05310	0.34379301
97	Fatty acid degradation_Homo sapiens_hsa00071	0.34040599
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31902040
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.31633343
100	Histidine metabolism_Homo sapiens_hsa00340	0.29993070

EGFEM1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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