EGFL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)9.38299447
2lymph vessel development (GO:0001945)8.69423596
3positive regulation of vasculogenesis (GO:2001214)8.54547830
4vascular endothelial growth factor signaling pathway (GO:0038084)7.55199201
5regulation of vasculogenesis (GO:2001212)7.10153600
6endothelial tube morphogenesis (GO:0061154)6.87161347
7morphogenesis of an endothelium (GO:0003159)6.87161347
8blood vessel maturation (GO:0001955)6.76158576
9cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.73037507
10surfactant homeostasis (GO:0043129)6.32271803
11lymphangiogenesis (GO:0001946)6.30934783
12negative regulation of erythrocyte differentiation (GO:0045647)6.15819910
13regulation of endothelial cell differentiation (GO:0045601)5.53440651
14endothelial cell differentiation (GO:0045446)5.28021965
15aggressive behavior (GO:0002118)5.21818307
16retina vasculature morphogenesis in camera-type eye (GO:0061299)4.96695100
17basement membrane organization (GO:0071711)4.81731219
18hyperosmotic salinity response (GO:0042538)4.78279259
19negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.77058780
20chemical homeostasis within a tissue (GO:0048875)4.69083479
21sprouting angiogenesis (GO:0002040)4.66020017
22heart trabecula formation (GO:0060347)4.64371464
23vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.61107312
24protein kinase C signaling (GO:0070528)4.57972951
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.50007874
26glomerular filtration (GO:0003094)4.43211905
27venous blood vessel morphogenesis (GO:0048845)4.42801733
28ovulation from ovarian follicle (GO:0001542)4.28240068
29positive regulation of odontogenesis (GO:0042482)4.27498607
30regulation of female receptivity (GO:0045924)4.26090789
31female mating behavior (GO:0060180)4.24906257
32renal filtration (GO:0097205)4.23472973
33positive regulation of endothelial cell differentiation (GO:0045603)4.19107833
34blood vessel endothelial cell migration (GO:0043534)4.15114236
35positive regulation of systemic arterial blood pressure (GO:0003084)4.14953865
36embryonic heart tube development (GO:0035050)4.04543702
37negative regulation of blood vessel endothelial cell migration (GO:0043537)4.03977859
38negative regulation of nitric-oxide synthase activity (GO:0051001)3.96998614
39negative regulation of endothelial cell apoptotic process (GO:2000352)3.96314021
40* vasculogenesis (GO:0001570)3.96029681
41angiogenesis involved in wound healing (GO:0060055)3.94581987
42regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.93015420
43ribosomal small subunit assembly (GO:0000028)3.91655520
44endothelial cell morphogenesis (GO:0001886)3.91116359
45patterning of blood vessels (GO:0001569)3.90301188
46Peyers patch development (GO:0048541)3.84484503
47mucosal-associated lymphoid tissue development (GO:0048537)3.84484503
48definitive hemopoiesis (GO:0060216)3.81594923
49cAMP biosynthetic process (GO:0006171)3.75580542
50mature B cell differentiation involved in immune response (GO:0002313)3.74649831
51viral transcription (GO:0019083)3.72606324
52grooming behavior (GO:0007625)3.69276093
53transcytosis (GO:0045056)3.67756623
54hyaluronan catabolic process (GO:0030214)3.67455080
55endothelial cell proliferation (GO:0001935)3.59669749
56negative regulation of vascular permeability (GO:0043116)3.59331922
57cell migration involved in sprouting angiogenesis (GO:0002042)3.56547557
58translational termination (GO:0006415)3.53633586
59endothelial cell chemotaxis (GO:0035767)3.49662622
60positive regulation of B cell differentiation (GO:0045579)3.44890573
61regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.44129269
62negative regulation of endothelial cell migration (GO:0010596)3.43378539
63negative regulation of cell size (GO:0045792)3.40296131
64positive regulation of urine volume (GO:0035810)3.36883168
65positive regulation of fatty acid biosynthetic process (GO:0045723)3.35217272
66trabecula morphogenesis (GO:0061383)3.26928252
67protein maturation by protein folding (GO:0022417)3.26678257
68cell migration involved in heart development (GO:0060973)3.26476086
69autophagic vacuole fusion (GO:0000046)3.22979739
70regulation of blood vessel endothelial cell migration (GO:0043535)3.19358217
71heart trabecula morphogenesis (GO:0061384)3.19118929
72pinocytosis (GO:0006907)3.18138015
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17665863
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16287065
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16287065
76regulation of vascular permeability (GO:0043114)3.16186305
77translational elongation (GO:0006414)3.10741765
78drinking behavior (GO:0042756)3.10450216
79platelet dense granule organization (GO:0060155)3.06894419
80regulation of endothelial cell apoptotic process (GO:2000351)3.02375009
81positive regulation of protein kinase C signaling (GO:0090037)3.02033491
82peptidyl-tyrosine autophosphorylation (GO:0038083)3.01315535
83negative regulation of platelet activation (GO:0010544)3.01210171
84UV protection (GO:0009650)2.99541922
85pentose-phosphate shunt (GO:0006098)2.99296662
86endothelial cell migration (GO:0043542)2.98316767
87ventricular trabecula myocardium morphogenesis (GO:0003222)2.98291848
88thrombin receptor signaling pathway (GO:0070493)2.96785318
89cardiac myofibril assembly (GO:0055003)2.93359543
90blood vessel remodeling (GO:0001974)2.93035535
91mRNA transcription from RNA polymerase II promoter (GO:0042789)2.92074872
92positive regulation of cell junction assembly (GO:1901890)2.91823835
93positive regulation of focal adhesion assembly (GO:0051894)2.91823835
94establishment of endothelial barrier (GO:0061028)2.89660301
95response to thyroid hormone (GO:0097066)2.88928630
96sarcomere organization (GO:0045214)2.87926249
97tricarboxylic acid metabolic process (GO:0072350)2.87333020
98negative regulation of DNA biosynthetic process (GO:2000279)2.86647972
99negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.85279864
100negative regulation of adherens junction organization (GO:1903392)2.83590196
101negative regulation of focal adhesion assembly (GO:0051895)2.83590196
102negative regulation of cell junction assembly (GO:1901889)2.83590196
103nucleotide salvage (GO:0043173)2.82996878
104cellular response to nitric oxide (GO:0071732)2.82864394
105regulation of urine volume (GO:0035809)2.81759722
106phagocytosis, recognition (GO:0006910)2.81541203
107regulation of endothelial cell migration (GO:0010594)2.81329773
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80991373
109hyperosmotic response (GO:0006972)2.80774808
110substrate-dependent cell migration (GO:0006929)2.79105535
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78895631
112phosphatidylglycerol biosynthetic process (GO:0006655)2.77921171
113bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75550125
114cyclic purine nucleotide metabolic process (GO:0052652)2.74976394
115blood coagulation, intrinsic pathway (GO:0007597)2.74818511
116nephron epithelium development (GO:0072009)2.74047310
117protein targeting to ER (GO:0045047)2.73125962
118prostaglandin biosynthetic process (GO:0001516)2.72889861
119prostanoid biosynthetic process (GO:0046457)2.72889861
120phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.72888338
121cotranslational protein targeting to membrane (GO:0006613)2.72383504
122valine metabolic process (GO:0006573)2.72334247
123purine nucleotide salvage (GO:0032261)2.71200171
124cellular hyperosmotic response (GO:0071474)2.70967742
125negative regulation of nitric oxide biosynthetic process (GO:0045019)2.70876680
126trabecula formation (GO:0060343)2.70578488
127negative regulation of endothelial cell proliferation (GO:0001937)2.70398847
128viral life cycle (GO:0019058)2.70306321
129fatty acid transmembrane transport (GO:1902001)2.70238764
130negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.69419435
131pentose metabolic process (GO:0019321)2.68959559
132negative regulation of necrotic cell death (GO:0060547)2.67035691
133ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.66914306
134regulation of transmission of nerve impulse (GO:0051969)2.66797297
135negative regulation of B cell apoptotic process (GO:0002903)2.66287339
136positive regulation of lipoprotein lipase activity (GO:0051006)2.66069238
137positive regulation of triglyceride lipase activity (GO:0061365)2.66069238
138coronary vasculature morphogenesis (GO:0060977)2.65585856
139positive regulation of endothelial cell migration (GO:0010595)2.65129926
140cyclic nucleotide biosynthetic process (GO:0009190)2.64552820
141negative regulation of Rho protein signal transduction (GO:0035024)2.62896258
142negative regulation of monooxygenase activity (GO:0032769)2.61236975
143negative regulation of epithelial cell migration (GO:0010633)2.60705185
144cell volume homeostasis (GO:0006884)2.60596682
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60278607
146positive regulation of adherens junction organization (GO:1903393)2.58454597
147protein localization to endoplasmic reticulum (GO:0070972)2.57323553
148ribosomal small subunit biogenesis (GO:0042274)2.56774352
149negative regulation of cell fate specification (GO:0009996)2.56276507
150lung vasculature development (GO:0060426)2.55612764
151embryonic foregut morphogenesis (GO:0048617)2.54959104
152artery development (GO:0060840)2.54312194
153arginine catabolic process (GO:0006527)2.53413281
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.53411202
155glucose catabolic process (GO:0006007)2.52671121
156cellular response to thyroid hormone stimulus (GO:0097067)2.50217344
157renal absorption (GO:0070293)2.44050823
158regulation of necrotic cell death (GO:0010939)2.43800786
159NADPH regeneration (GO:0006740)2.43012696
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41407643
161deoxyribose phosphate biosynthetic process (GO:0046385)2.40966366
1622-deoxyribonucleotide biosynthetic process (GO:0009265)2.40966366
163maternal behavior (GO:0042711)2.40578593
164deoxyribonucleotide catabolic process (GO:0009264)2.36931699
165poly(A)+ mRNA export from nucleus (GO:0016973)2.35484340
166anatomical structure maturation (GO:0071695)2.35051571
167neuron remodeling (GO:0016322)2.33496061
168negative regulation of granulocyte differentiation (GO:0030853)2.33328724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.54074961
2GATA1_22025678_ChIP-Seq_K562_Human4.32373952
3* GATA2_21666600_ChIP-Seq_HMVEC_Human3.43923843
4* ELK3_25401928_ChIP-Seq_HUVEC_Human3.03733104
5SCL_19346495_ChIP-Seq_HPC-7_Human3.00953103
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.99513371
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92522131
8CLOCK_20551151_ChIP-Seq_293T_Human2.87777270
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86655963
10ZNF263_19887448_ChIP-Seq_K562_Human2.77676294
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56541109
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45571869
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14390017
14E2F7_22180533_ChIP-Seq_HELA_Human2.02486332
15P68_20966046_ChIP-Seq_HELA_Human1.96573879
16* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92755569
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.87433229
18GATA1_19941826_ChIP-Seq_K562_Human1.79248675
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74919080
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.73092010
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.72573620
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71952964
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69602548
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68897048
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68683271
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67674711
27TBX20_22080862_ChIP-Seq_HEART_Mouse1.67287726
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.67287726
29* BCL6_27268052_Chip-Seq_Bcells_Human1.64176161
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63395862
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62932361
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62615030
33VDR_24763502_ChIP-Seq_THP-1_Human1.62181725
34CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61914104
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.61908582
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60648404
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57581258
38VDR_21846776_ChIP-Seq_THP-1_Human1.57579217
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55018110
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54987775
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54890439
42* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53741781
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.52818166
44MAF_26560356_Chip-Seq_TH1_Human1.46369860
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43843009
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.42601970
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.42519734
48LXR_22292898_ChIP-Seq_THP-1_Human1.41236401
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38308141
50CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37157751
51BCOR_27268052_Chip-Seq_Bcells_Human1.36600858
52CTCF_26484167_Chip-Seq_Bcells_Mouse1.36569724
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33758782
54CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29368051
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29181167
56MYC_22102868_ChIP-Seq_BL_Human1.28066279
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.27902988
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.27599883
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26789367
60* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26439573
61* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26360329
62* TCF7_22412390_ChIP-Seq_EML_Mouse1.25851083
63CTCF_21964334_Chip-Seq_Bcells_Human1.25553653
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23924897
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23802018
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23504328
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23208643
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23130062
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23031488
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22388638
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21637866
72E2F1_20622854_ChIP-Seq_HELA_Human1.21191886
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21177337
74* LXR_22158963_ChIP-Seq_LIVER_Mouse1.20713442
75* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20704898
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20688315
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.20645739
78CTCF_27219007_Chip-Seq_Bcells_Human1.20347289
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20150174
80PHF8_20622854_ChIP-Seq_HELA_Human1.19665096
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.18814943
82RACK7_27058665_Chip-Seq_MCF-7_Human1.18746187
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17345224
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16810696
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.16274178
86* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16080613
87* KDM2B_26808549_Chip-Seq_K562_Human1.16072850
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15588434
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15316789
90* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15192393
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15106585
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14688466
93SPI1_20517297_ChIP-Seq_HL60_Human1.14615569
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14256076
95* SMC4_20622854_ChIP-Seq_HELA_Human1.14084927
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13869076
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13267543
98* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12490893
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11769107
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11525537
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11375722
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.10442756
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09776007
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09474830
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09155956
106* NCOR1_26117541_ChIP-Seq_K562_Human1.08338156
107MAF_26560356_Chip-Seq_TH2_Human1.08007172
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07760818
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07713266
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07420712
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06175094
112XRN2_22483619_ChIP-Seq_HELA_Human1.06164425
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05945443
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05576829
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05167749
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.05075197
117SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05057185
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04976239
119STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04921152
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03536255
121KDM2B_26808549_Chip-Seq_DND41_Human1.03369933
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03082166
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02861661
124GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01909194
125ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01508388
126SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01264951
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00046806
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99902967
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99701534
130* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99334772
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99131219
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99019913
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98177037
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.97992405
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97957801
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97751377
137SPI1_23127762_ChIP-Seq_K562_Human0.97425375
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97156407
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97143475
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96365765
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95052173
142AR_21909140_ChIP-Seq_LNCAP_Human0.93438672
143UTX_26944678_Chip-Seq_JUKART_Human0.93390432
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91920590
145* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91867922
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.91656909
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.91533319
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91483373
149* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91050336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.24770802
2MP0001879_abnormal_lymphatic_vessel6.20980399
3MP0005167_abnormal_blood-brain_barrier5.71183233
4MP0004272_abnormal_basement_membrane3.57182049
5MP0004084_abnormal_cardiac_muscle3.52379615
6MP0003828_pulmonary_edema3.03353626
7MP0003724_increased_susceptibility_to2.80493507
8MP0006054_spinal_hemorrhage2.67136561
9MP0004215_abnormal_myocardial_fiber2.49306268
10MP0006138_congestive_heart_failure2.41818214
11MP0004147_increased_porphyrin_level2.38349197
12MP0009379_abnormal_foot_pigmentation2.21918625
13MP0004036_abnormal_muscle_relaxation2.21365486
14MP0005058_abnormal_lysosome_morphology2.06863977
15MP0000751_myopathy1.95344526
16MP0008775_abnormal_heart_ventricle1.94674176
17MP0005330_cardiomyopathy1.93566036
18MP0005385_cardiovascular_system_phenoty1.91981595
19MP0001544_abnormal_cardiovascular_syste1.91981595
20MP0000767_abnormal_smooth_muscle1.86913765
21MP0003279_aneurysm1.84714818
22MP0000003_abnormal_adipose_tissue1.80278326
23MP0002837_dystrophic_cardiac_calcinosis1.78539197
24MP0009697_abnormal_copulation1.78412939
25MP0000678_abnormal_parathyroid_gland1.75466244
26MP0000343_altered_response_to1.70077444
27MP0010630_abnormal_cardiac_muscle1.64212227
28MP0003806_abnormal_nucleotide_metabolis1.63421351
29MP0005375_adipose_tissue_phenotype1.61632758
30MP0002127_abnormal_cardiovascular_syste1.60549509
31MP0003567_abnormal_fetal_cardiomyocyte1.60003644
32MP0000249_abnormal_blood_vessel1.59982945
33MP0002138_abnormal_hepatobiliary_system1.56412063
34MP0002332_abnormal_exercise_endurance1.55294879
35MP0005165_increased_susceptibility_to1.54360304
36MP0000749_muscle_degeneration1.54215109
37MP0004484_altered_response_of1.54038775
38MP0005451_abnormal_body_composition1.53628671
39MP0005670_abnormal_white_adipose1.50152861
40MP0001849_ear_inflammation1.45791088
41MP0002972_abnormal_cardiac_muscle1.45213930
42MP0005409_darkened_coat_color1.45040600
43MP0004808_abnormal_hematopoietic_stem1.44891302
44MP0005084_abnormal_gallbladder_morpholo1.43142385
45MP0005595_abnormal_vascular_smooth1.41698279
46MP0002128_abnormal_blood_circulation1.41446389
47MP0002396_abnormal_hematopoietic_system1.40013722
48MP0004130_abnormal_muscle_cell1.38980530
49MP0009840_abnormal_foam_cell1.33709130
50MP0000681_abnormal_thyroid_gland1.31770678
51MP0000465_gastrointestinal_hemorrhage1.31643603
52MP0003191_abnormal_cellular_cholesterol1.30137999
53MP0003075_altered_response_to1.20488162
54MP0005397_hematopoietic_system_phenotyp1.19458989
55MP0001545_abnormal_hematopoietic_system1.19458989
56MP0009278_abnormal_bone_marrow1.19275944
57MP0003646_muscle_fatigue1.19009716
58MP0005620_abnormal_muscle_contractility1.17013234
59MP0000750_abnormal_muscle_regeneration1.17003632
60MP0000013_abnormal_adipose_tissue1.14739790
61* MP0002925_abnormal_cardiovascular_devel1.13744047
62MP0004087_abnormal_muscle_fiber1.13086074
63MP0004782_abnormal_surfactant_physiolog1.12489676
64* MP0001614_abnormal_blood_vessel1.10546109
65MP0001958_emphysema1.07160618
66* MP0004085_abnormal_heartbeat1.06495473
67MP0003566_abnormal_cell_adhesion1.06189279
68MP0000266_abnormal_heart_morphology1.05079442
69MP0008004_abnormal_stomach_pH1.03193629
70MP0000230_abnormal_systemic_arterial1.02785910
71MP0003943_abnormal_hepatobiliary_system1.02621521
72MP0006036_abnormal_mitochondrial_physio0.97644737
73MP0002295_abnormal_pulmonary_circulatio0.94580571
74MP0002933_joint_inflammation0.94236027
75MP0002106_abnormal_muscle_physiology0.92745457
76MP0004883_abnormal_blood_vessel0.92250174
77MP0003705_abnormal_hypodermis_morpholog0.92165936
78MP0002132_abnormal_respiratory_system0.91761853
79MP0003172_abnormal_lysosome_physiology0.88638885
80MP0005535_abnormal_body_temperature0.88409423
81MP0002877_abnormal_melanocyte_morpholog0.88160087
82MP0003221_abnormal_cardiomyocyte_apopto0.86942453
83MP0005220_abnormal_exocrine_pancreas0.86557526
84MP0005164_abnormal_response_to0.83629724
85MP0004510_myositis0.81811357
86MP0005645_abnormal_hypothalamus_physiol0.81796358
87MP0005083_abnormal_biliary_tract0.81451755
88MP0005623_abnormal_meninges_morphology0.81202845
89MP0001915_intracranial_hemorrhage0.80700870
90MP0003638_abnormal_response/metabolism_0.78373120
91MP0003300_gastrointestinal_ulcer0.74870616
92MP0002086_abnormal_extraembryonic_tissu0.74569602
93MP0002971_abnormal_brown_adipose0.74377234
94MP0008875_abnormal_xenobiotic_pharmacok0.73563942
95MP0004145_abnormal_muscle_electrophysio0.72711989
96MP0005666_abnormal_adipose_tissue0.71961356
97MP0003984_embryonic_growth_retardation0.70575267
98* MP0001784_abnormal_fluid_regulation0.69317431
99MP0002166_altered_tumor_susceptibility0.69256881
100MP0002088_abnormal_embryonic_growth/wei0.68815044
101MP0010329_abnormal_lipoprotein_level0.68809122
102MP0005369_muscle_phenotype0.68733358
103MP0001661_extended_life_span0.68246072
104MP0005360_urolithiasis0.66752386
105MP0005319_abnormal_enzyme/_coenzyme0.64975188
106MP0008995_early_reproductive_senescence0.64552239
107MP0001764_abnormal_homeostasis0.64025954
108MP0002269_muscular_atrophy0.63173393
109MP0001853_heart_inflammation0.62882941
110MP0003303_peritoneal_inflammation0.62590884
111MP0009643_abnormal_urine_homeostasis0.60981599
112MP0002398_abnormal_bone_marrow0.59493715
113MP0009931_abnormal_skin_appearance0.58299549
114MP0004185_abnormal_adipocyte_glucose0.58149501
115MP0002429_abnormal_blood_cell0.58095709
116MP0001851_eye_inflammation0.58074784
117MP0000598_abnormal_liver_morphology0.57740798
118MP0000759_abnormal_skeletal_muscle0.57191057
119MP0003122_maternal_imprinting0.57132094
120MP0008260_abnormal_autophagy0.55951637
121MP0005334_abnormal_fat_pad0.55163525
122MP0005166_decreased_susceptibility_to0.53619698
123* MP0003948_abnormal_gas_homeostasis0.53380623
124MP0005376_homeostasis/metabolism_phenot0.52893211
125MP0003186_abnormal_redox_activity0.52757947
126MP0005464_abnormal_platelet_physiology0.52742345
127MP0000747_muscle_weakness0.52671890
128MP0005266_abnormal_metabolism0.52343914
129MP0004233_abnormal_muscle_weight0.52027066
130MP0002970_abnormal_white_adipose0.51895619
131MP0001175_abnormal_lung_morphology0.50882450
132MP0003137_abnormal_impulse_conducting0.50779193
133MP0002133_abnormal_respiratory_system0.50150267
134MP0008874_decreased_physiological_sensi0.49998703
135MP0005501_abnormal_skin_physiology0.49740429

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)7.20115261
2Spontaneous hematomas (HP:0007420)5.89322835
3Hematochezia (HP:0002573)5.13936215
4Abnormality of the nasal mucosa (HP:0000433)4.90526021
5Esophageal varix (HP:0002040)4.16228555
6Ventricular tachycardia (HP:0004756)4.13311860
7Nonimmune hydrops fetalis (HP:0001790)4.12845461
8Cerebral hemorrhage (HP:0001342)4.05148645
9Sudden death (HP:0001699)4.01513814
10Lymphangioma (HP:0100764)3.83865161
11Conjunctival telangiectasia (HP:0000524)3.64963525
12Mesangial abnormality (HP:0001966)3.52086538
13Muscle fiber splitting (HP:0003555)3.49402093
14Centrally nucleated skeletal muscle fibers (HP:0003687)3.45794431
15Visceral angiomatosis (HP:0100761)3.28817914
16J-shaped sella turcica (HP:0002680)3.24089358
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.20788041
18Supraventricular arrhythmia (HP:0005115)3.16296466
19Hemangiomatosis (HP:0007461)3.14101532
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.12804660
21Broad metatarsal (HP:0001783)3.12714637
22Atrial fibrillation (HP:0005110)3.11619114
23Lipoatrophy (HP:0100578)3.11512749
24Microcytic anemia (HP:0001935)3.07736868
25Increased connective tissue (HP:0009025)3.01980183
26Exercise-induced muscle cramps (HP:0003710)2.98896030
27Supraventricular tachycardia (HP:0004755)2.93968239
28Cerebral palsy (HP:0100021)2.93919105
29Hypoglycemic coma (HP:0001325)2.91667788
30Primary atrial arrhythmia (HP:0001692)2.89679115
31Petechiae (HP:0000967)2.89315939
32Cavernous hemangioma (HP:0001048)2.87226848
33Hyperthyroidism (HP:0000836)2.86976028
34Menorrhagia (HP:0000132)2.86859714
35Acute lymphatic leukemia (HP:0006721)2.82365691
36Hypertensive crisis (HP:0100735)2.79762984
37Truncus arteriosus (HP:0001660)2.77686742
38Myoglobinuria (HP:0002913)2.76566302
39Distal lower limb muscle weakness (HP:0009053)2.69048797
40Dilated cardiomyopathy (HP:0001644)2.68363788
41Growth hormone excess (HP:0000845)2.67814192
42Polygenic inheritance (HP:0010982)2.66484916
43Portal hypertension (HP:0001409)2.65960549
44Abnormality of cells of the erythroid lineage (HP:0012130)2.63468224
45Cerebral aneurysm (HP:0004944)2.58944981
46Distal lower limb amyotrophy (HP:0008944)2.58873579
47Palpitations (HP:0001962)2.56706194
48Myotonia (HP:0002486)2.56583632
49Deep venous thrombosis (HP:0002625)2.55730391
50Abnormal number of erythroid precursors (HP:0012131)2.54673547
51Rhabdomyolysis (HP:0003201)2.52715535
52Joint stiffness (HP:0001387)2.50273852
53Interstitial pulmonary disease (HP:0006530)2.49447614
54Abnormality of skeletal muscle fiber size (HP:0012084)2.48439553
55Mucosal telangiectasiae (HP:0100579)2.48363563
56Seborrheic dermatitis (HP:0001051)2.47353666
57Reticulocytosis (HP:0001923)2.47278625
58Dysostosis multiplex (HP:0000943)2.44480478
59Hydroureter (HP:0000072)2.42755499
60Congenital, generalized hypertrichosis (HP:0004540)2.42659824
61Dysautonomia (HP:0002459)2.42280894
62Atrioventricular block (HP:0001678)2.41193076
63Thrombocytosis (HP:0001894)2.38954780
64Porencephaly (HP:0002132)2.37928628
65Increased variability in muscle fiber diameter (HP:0003557)2.37302364
66Hepatosplenomegaly (HP:0001433)2.36153813
67Calf muscle hypertrophy (HP:0008981)2.35893296
68Hypertriglyceridemia (HP:0002155)2.35889844
69Aplastic anemia (HP:0001915)2.34684338
70Abnormality of the hepatic vasculature (HP:0006707)2.34628886
71Difficulty running (HP:0009046)2.34147008
72Prolonged bleeding time (HP:0003010)2.33846384
73Adactyly (HP:0009776)2.33147386
74Hepatic necrosis (HP:0002605)2.30257270
75Right ventricular cardiomyopathy (HP:0011663)2.29775785
76Cervical subluxation (HP:0003308)2.29435507
77Reticulocytopenia (HP:0001896)2.29246594
78Hemorrhage of the eye (HP:0011885)2.28978818
79Skull defect (HP:0001362)2.21680625
80Muscle stiffness (HP:0003552)2.20988372
81Impaired platelet aggregation (HP:0003540)2.20644233
82Abnormal platelet function (HP:0011869)2.20644233
83Abnormality of fatty-acid metabolism (HP:0004359)2.20363547
84Purpura (HP:0000979)2.19105192
85Hyporeflexia of lower limbs (HP:0002600)2.17325126
86Exercise-induced myalgia (HP:0003738)2.16499734
87Venous abnormality (HP:0002624)2.16445342
88Subaortic stenosis (HP:0001682)2.15978619
89Abnormality of the left ventricular outflow tract (HP:0011103)2.15978619
90Gastrointestinal dysmotility (HP:0002579)2.15906454
91EMG: myopathic abnormalities (HP:0003458)2.13928151
92Abnormal pupillary function (HP:0007686)2.13595085
93Microvesicular hepatic steatosis (HP:0001414)2.13479333
94Trismus (HP:0000211)2.12816453
95Agammaglobulinemia (HP:0004432)2.12737745
96Cellulitis (HP:0100658)2.12463880
97Limb-girdle muscle atrophy (HP:0003797)2.11200914
98Capillary hemangiomas (HP:0005306)2.11189298
99Absent hand (HP:0004050)2.11062439
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10877974
101Dicarboxylic aciduria (HP:0003215)2.10877974
102Delayed CNS myelination (HP:0002188)2.10380759
103Difficulty climbing stairs (HP:0003551)2.09309432
104Neonatal death (HP:0003811)2.08339067
105Pulmonary artery stenosis (HP:0004415)2.05849030
106Asymmetric septal hypertrophy (HP:0001670)2.04178099
107Ileus (HP:0002595)2.02894434
108Mucopolysacchariduria (HP:0008155)2.02865358
109Urinary glycosaminoglycan excretion (HP:0003541)2.02865358
110Muscle hypertrophy of the lower extremities (HP:0008968)2.02859720
111Abnormality of the calf musculature (HP:0001430)2.02293626
112Abnormality of reticulocytes (HP:0004312)2.02225664
113Pulmonary hypertension (HP:0002092)2.01152231
114Hepatocellular necrosis (HP:0001404)2.00562144
115Ragged-red muscle fibers (HP:0003200)1.99677455
116Facial diplegia (HP:0001349)1.98674737
117Large hands (HP:0001176)1.98348718
118Abnormality of polysaccharide metabolism (HP:0011012)1.98092328
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98092328
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98092328
121Severe visual impairment (HP:0001141)1.97541851
122Increased serum ferritin (HP:0003281)1.95071918
123Epistaxis (HP:0000421)1.94400323
124Achilles tendon contracture (HP:0001771)1.93834949
125Asymmetry of the thorax (HP:0001555)1.93409291
126Intestinal polyposis (HP:0200008)1.91976145
127Spinal rigidity (HP:0003306)1.91971388
128Intestinal polyp (HP:0005266)1.91905053
129Colitis (HP:0002583)1.91131263
130Thrombophlebitis (HP:0004418)1.91029892
131Testicular atrophy (HP:0000029)1.90978599
132Joint hemorrhage (HP:0005261)1.90914078
133Stroke (HP:0001297)1.90724568
134Panhypogammaglobulinemia (HP:0003139)1.90659575
135Protrusio acetabuli (HP:0003179)1.90353054
136Metaphyseal dysplasia (HP:0100255)1.90188685
137Increased muscle lipid content (HP:0009058)1.90041500
138Areflexia of lower limbs (HP:0002522)1.89494552
139Reduced subcutaneous adipose tissue (HP:0003758)1.89177614
140Elevated erythrocyte sedimentation rate (HP:0003565)1.89000164
141Chronic obstructive pulmonary disease (HP:0006510)1.88601136
142Obstructive lung disease (HP:0006536)1.88601136
143Increased mean platelet volume (HP:0011877)1.87861750
144High pitched voice (HP:0001620)1.87666661
145Annular pancreas (HP:0001734)1.84969735
146Venous insufficiency (HP:0005293)1.84347892
147Abnormality of iron homeostasis (HP:0011031)1.83832473
148Progressive muscle weakness (HP:0003323)1.83108141
149Heart block (HP:0012722)1.81705359
150Pancreatic islet-cell hyperplasia (HP:0004510)1.80258990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.93392498
2TGFBR23.74075108
3TGFBR13.41464769
4MAP2K32.16455225
5GRK12.10072840
6MYLK2.05427455
7TIE110.9913952
8BCKDK1.97161378
9PKN21.61089269
10ERN11.59576162
11PTK2B1.56217335
12NME21.52030865
13FLT31.51170933
14TTN1.35983041
15RIPK11.31999112
16PAK41.26761154
17MAP3K111.26591863
18TESK21.25915943
19PRKG21.20554942
20TEC1.19882291
21TRIB31.16885380
22SMG11.15911386
23PDK21.15551700
24KIT1.13526348
25LRRK21.07645735
26EPHB21.07532097
27ARAF1.04951422
28ABL21.03472009
29WEE11.02200184
30NTRK10.97988428
31BMX0.96842160
32TAOK30.94147322
33DAPK10.92678401
34MAP4K10.92241767
35MAPK120.92221012
36VRK20.90556406
37MAP3K130.90549773
38PTK60.90252031
39TESK10.89487738
40MAP3K30.87170046
41OBSCN0.86320018
42TNK20.80576362
43IRAK30.76434618
44FER0.75887471
45PRKD20.75744198
46ILK0.73943649
47PRKD30.73814664
48TBK10.73292536
49TAOK20.71715451
50GRK50.70791102
51PHKG20.70670514
52PHKG10.70670514
53MAPKAPK30.70085744
54MARK20.63066821
55PRKD10.62802933
56FGFR40.60759387
57RPS6KA20.60530374
58SCYL20.60002334
59PRKAA20.59945381
60DAPK20.59546699
61PBK0.58522776
62BUB10.56660339
63MAP2K20.55710603
64MUSK0.54499808
65ACVR1B0.53251512
66DMPK0.52960718
67SYK0.52532692
68ZAP700.52442412
69CSF1R0.48760812
70PRPF4B0.46122852
71BTK0.46073653
72ITK0.45700354
73MATK0.45108937
74HIPK20.45045837
75FES0.43658939
76LMTK20.43107505
77PDK30.42979174
78PDK40.42979174
79INSRR0.42638036
80HCK0.41584763
81AURKA0.41346497
82RAF10.41015141
83DYRK30.40589843
84PIM20.40447252
85DYRK1B0.40364455
86EPHB10.40011506
87TSSK60.39429004
88MAP3K10.38545191
89RPS6KA40.38436458
90CDK90.35833025
91AKT20.33983801
92JAK30.32277584
93PDGFRA0.32160333
94MAPK30.32028485
95MAP2K60.30936249
96LCK0.30815882
97PAK10.30039580
98CAMK10.29510214
99GRK60.28982007
100MAP3K70.28755021
101MTOR0.28397890
102NEK10.28145711
103MAPK40.27697669
104CDK80.27308722
105CDK70.27208526
106BRSK20.27086148
107TRPM70.27075715
108MAP3K60.26859204
109PIK3CG0.26745893
110IGF1R0.26495113
111PAK20.26411962
112NLK0.26194400
113ICK0.25936901
114MAPK70.25930845
115PDPK10.25533118
116NEK90.25504907
117RPS6KB20.25347581
118DAPK30.25152945
119CSK0.24971518
120STK100.24926851
121CAMK40.23949255
122MAPK100.23740253
123TYK20.23713532
124MAP3K80.23675318
125PTK20.23252741
126PKN10.23220470
127RPS6KL10.22895130
128RPS6KC10.22895130
129IKBKB0.22542009
130RPS6KA60.21669466
131MARK30.19991395
132MAP3K100.19667540
133CAMKK20.19560678
134SRC0.17386608
135MAPK150.15132775
136EGFR0.14073358
137GSK3A0.13612777
138EEF2K0.13578279
139VRK10.13467024
140MAP2K10.13268032
141MAP3K120.13151652
142CCNB10.12782227
143SIK10.12578784

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.80546526
2Other glycan degradation_Homo sapiens_hsa005113.94486933
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.93777066
4Ribosome_Homo sapiens_hsa030103.88568817
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87750191
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.81055074
7DNA replication_Homo sapiens_hsa030302.75311651
8Fatty acid degradation_Homo sapiens_hsa000712.52008377
9Propanoate metabolism_Homo sapiens_hsa006402.30023625
10Caffeine metabolism_Homo sapiens_hsa002322.24106864
11Leukocyte transendothelial migration_Homo sapiens_hsa046702.02566163
12Dilated cardiomyopathy_Homo sapiens_hsa054141.97292858
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82647704
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82110783
15Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.74798111
16Parkinsons disease_Homo sapiens_hsa050121.71437035
17Focal adhesion_Homo sapiens_hsa045101.67443777
18ECM-receptor interaction_Homo sapiens_hsa045121.67020498
19Acute myeloid leukemia_Homo sapiens_hsa052211.66258561
20PPAR signaling pathway_Homo sapiens_hsa033201.64230674
21Mismatch repair_Homo sapiens_hsa034301.63980640
22Arginine biosynthesis_Homo sapiens_hsa002201.61211267
23Platelet activation_Homo sapiens_hsa046111.56936687
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.56254194
25Carbon metabolism_Homo sapiens_hsa012001.51212329
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50485406
27Fructose and mannose metabolism_Homo sapiens_hsa000511.49845779
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42480078
29Cardiac muscle contraction_Homo sapiens_hsa042601.37733500
30Fatty acid metabolism_Homo sapiens_hsa012121.34140283
31Glutathione metabolism_Homo sapiens_hsa004801.32751651
32Notch signaling pathway_Homo sapiens_hsa043301.24878978
33Complement and coagulation cascades_Homo sapiens_hsa046101.24555637
34Phenylalanine metabolism_Homo sapiens_hsa003601.23835845
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22765052
36Tyrosine metabolism_Homo sapiens_hsa003501.19407370
37Renin-angiotensin system_Homo sapiens_hsa046141.18808162
38HIF-1 signaling pathway_Homo sapiens_hsa040661.17957527
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16020926
40Adherens junction_Homo sapiens_hsa045201.14984788
41Small cell lung cancer_Homo sapiens_hsa052221.11920146
42Sulfur relay system_Homo sapiens_hsa041221.11143255
43Base excision repair_Homo sapiens_hsa034101.10844253
44Rap1 signaling pathway_Homo sapiens_hsa040151.10391700
45Lysosome_Homo sapiens_hsa041421.09337608
46Tryptophan metabolism_Homo sapiens_hsa003801.08799181
47Proteasome_Homo sapiens_hsa030501.08379289
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07634665
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06374164
50Huntingtons disease_Homo sapiens_hsa050161.05063271
51Oxidative phosphorylation_Homo sapiens_hsa001901.04794584
52Viral myocarditis_Homo sapiens_hsa054161.03793396
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.03590657
54Folate biosynthesis_Homo sapiens_hsa007901.01867119
55Bile secretion_Homo sapiens_hsa049760.99991735
56Chronic myeloid leukemia_Homo sapiens_hsa052200.99977691
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.99914124
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99101764
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95850711
60beta-Alanine metabolism_Homo sapiens_hsa004100.94636632
61Malaria_Homo sapiens_hsa051440.93045265
62Pyruvate metabolism_Homo sapiens_hsa006200.91894473
63Thyroid cancer_Homo sapiens_hsa052160.90300981
64Insulin resistance_Homo sapiens_hsa049310.90188546
65Renin secretion_Homo sapiens_hsa049240.90062244
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90027789
67Pyrimidine metabolism_Homo sapiens_hsa002400.88277417
68Alzheimers disease_Homo sapiens_hsa050100.88131369
69VEGF signaling pathway_Homo sapiens_hsa043700.87924920
70Asthma_Homo sapiens_hsa053100.87494087
71Fatty acid elongation_Homo sapiens_hsa000620.85461413
72Prion diseases_Homo sapiens_hsa050200.82890393
73Arachidonic acid metabolism_Homo sapiens_hsa005900.82732954
74Bladder cancer_Homo sapiens_hsa052190.82255850
75N-Glycan biosynthesis_Homo sapiens_hsa005100.80825071
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80220441
77Arginine and proline metabolism_Homo sapiens_hsa003300.77582105
78Tight junction_Homo sapiens_hsa045300.77491036
79Nitrogen metabolism_Homo sapiens_hsa009100.76613388
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76101077
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.75344402
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75278546
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74418023
84One carbon pool by folate_Homo sapiens_hsa006700.73134870
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.70517146
86African trypanosomiasis_Homo sapiens_hsa051430.69601225
87Purine metabolism_Homo sapiens_hsa002300.68758356
88Peroxisome_Homo sapiens_hsa041460.66374555
89Biosynthesis of amino acids_Homo sapiens_hsa012300.66364617
90Leishmaniasis_Homo sapiens_hsa051400.64656493
91Spliceosome_Homo sapiens_hsa030400.64226905
92Galactose metabolism_Homo sapiens_hsa000520.60234110
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59621873
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58877842
95Pathways in cancer_Homo sapiens_hsa052000.58257768
96Pentose phosphate pathway_Homo sapiens_hsa000300.57883279
97Toxoplasmosis_Homo sapiens_hsa051450.57457483
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54925336
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.53259634
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52303678
101Systemic lupus erythematosus_Homo sapiens_hsa053220.51986102
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.51368711
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50613702
104Amoebiasis_Homo sapiens_hsa051460.50557140
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49453786
106Salmonella infection_Homo sapiens_hsa051320.48946581
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48468440
108Ovarian steroidogenesis_Homo sapiens_hsa049130.47667965
109Hematopoietic cell lineage_Homo sapiens_hsa046400.47559903
110Olfactory transduction_Homo sapiens_hsa047400.46901504
111Fat digestion and absorption_Homo sapiens_hsa049750.46572019
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46283580
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45895521
114Pertussis_Homo sapiens_hsa051330.44432741
115Calcium signaling pathway_Homo sapiens_hsa040200.44229726
116HTLV-I infection_Homo sapiens_hsa051660.42451301
117Gap junction_Homo sapiens_hsa045400.42065841
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42005799
119Shigellosis_Homo sapiens_hsa051310.41662077
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41441504
121Pancreatic cancer_Homo sapiens_hsa052120.41426684
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41157085
123Protein digestion and absorption_Homo sapiens_hsa049740.41035612
124Selenocompound metabolism_Homo sapiens_hsa004500.40827321
125Vitamin digestion and absorption_Homo sapiens_hsa049770.40659017
126ABC transporters_Homo sapiens_hsa020100.40024679
127AMPK signaling pathway_Homo sapiens_hsa041520.39567020
128Endocytosis_Homo sapiens_hsa041440.38671398
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38029305
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37941228
131Proteoglycans in cancer_Homo sapiens_hsa052050.37132880
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37122756
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37098378
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36455848
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35825630
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35187664
137Herpes simplex infection_Homo sapiens_hsa051680.35024213
138Ras signaling pathway_Homo sapiens_hsa040140.32829011
139Metabolic pathways_Homo sapiens_hsa011000.30857243
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.30610884

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