EGFL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)7.86106123
2regulation of pigment cell differentiation (GO:0050932)7.04288701
3central nervous system myelination (GO:0022010)5.94245093
4axon ensheathment in central nervous system (GO:0032291)5.94245093
5axon ensheathment (GO:0008366)5.92589292
6ensheathment of neurons (GO:0007272)5.92589292
7behavioral response to nicotine (GO:0035095)5.76362252
8presynaptic membrane assembly (GO:0097105)5.65562826
9myelination in peripheral nervous system (GO:0022011)5.51157461
10peripheral nervous system axon ensheathment (GO:0032292)5.51157461
11cell-cell junction maintenance (GO:0045217)5.39227857
12myelination (GO:0042552)5.39050824
13presynaptic membrane organization (GO:0097090)5.35351993
14neuron cell-cell adhesion (GO:0007158)5.06043083
15positive regulation of developmental pigmentation (GO:0048087)4.96780121
16negative regulation of telomere maintenance (GO:0032205)4.23311104
17DNA deamination (GO:0045006)4.09842224
18long-chain fatty acid biosynthetic process (GO:0042759)4.00599051
19postsynaptic membrane organization (GO:0001941)3.99518740
20negative regulation of neurotransmitter transport (GO:0051589)3.98450882
21response to pheromone (GO:0019236)3.93264577
22fatty acid elongation (GO:0030497)3.89719302
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86062486
24cell junction maintenance (GO:0034331)3.81621177
25negative regulation of neurotransmitter secretion (GO:0046929)3.76518509
26peripheral nervous system development (GO:0007422)3.74982737
27protein localization to synapse (GO:0035418)3.65575113
28fucose catabolic process (GO:0019317)3.63664322
29L-fucose metabolic process (GO:0042354)3.63664322
30L-fucose catabolic process (GO:0042355)3.63664322
31nephron tubule morphogenesis (GO:0072078)3.57172352
32nephron epithelium morphogenesis (GO:0072088)3.57172352
33neuron recognition (GO:0008038)3.52074979
34glomerulus development (GO:0032835)3.49409904
35positive regulation of synapse assembly (GO:0051965)3.49182214
36nonmotile primary cilium assembly (GO:0035058)3.47282216
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45631278
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44742703
39positive regulation of smooth muscle cell migration (GO:0014911)3.43946786
40cranial nerve structural organization (GO:0021604)3.38525394
41cerebral cortex radially oriented cell migration (GO:0021799)3.35293038
42ear development (GO:0043583)3.34579365
43positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.33593304
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.32527013
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30195852
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.30195852
47NADH dehydrogenase complex assembly (GO:0010257)3.30195852
48Leydig cell differentiation (GO:0033327)3.28128537
49platelet dense granule organization (GO:0060155)3.27395021
50axonal fasciculation (GO:0007413)3.27369014
51somite development (GO:0061053)3.26012503
52transmission of nerve impulse (GO:0019226)3.24576085
53regulation of developmental pigmentation (GO:0048070)3.19391280
54oligodendrocyte differentiation (GO:0048709)3.19270032
55protein complex biogenesis (GO:0070271)3.12907060
56cellular component maintenance (GO:0043954)3.11742334
57epithelial cilium movement (GO:0003351)3.09621690
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.07366857
59negative regulation of protein localization to cell surface (GO:2000009)3.07323819
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06784120
61ubiquinone biosynthetic process (GO:0006744)3.06212003
62neuron remodeling (GO:0016322)3.06163459
63neuronal ion channel clustering (GO:0045161)3.04256855
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02469756
65peptidyl-tyrosine autophosphorylation (GO:0038083)3.01059682
66cellular response to ATP (GO:0071318)2.99909941
67limb bud formation (GO:0060174)2.98754034
68membrane assembly (GO:0071709)2.98278984
69kidney morphogenesis (GO:0060993)2.98253391
70ubiquinone metabolic process (GO:0006743)2.97947271
71mitochondrial respiratory chain complex assembly (GO:0033108)2.93525323
72ATP synthesis coupled proton transport (GO:0015986)2.91225732
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91225732
74synaptic transmission, cholinergic (GO:0007271)2.90350868
75positive regulation of dendritic spine development (GO:0060999)2.89329917
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.87826093
77glutamate receptor signaling pathway (GO:0007215)2.86425678
78parturition (GO:0007567)2.85248236
79vocalization behavior (GO:0071625)2.82399920
80extracellular fibril organization (GO:0043206)2.81769048
81cornea development in camera-type eye (GO:0061303)2.81451862
82sulfation (GO:0051923)2.81012962
83negative regulation of axon extension (GO:0030517)2.80785346
84dendritic spine morphogenesis (GO:0060997)2.78384322
85N-acetylneuraminate metabolic process (GO:0006054)2.78011295
86photoreceptor cell differentiation (GO:0046530)2.77210566
87eye photoreceptor cell differentiation (GO:0001754)2.77210566
88substantia nigra development (GO:0021762)2.77056395
89piRNA metabolic process (GO:0034587)2.76421699
90cholesterol biosynthetic process (GO:0006695)2.75790496
91neurotransmitter-gated ion channel clustering (GO:0072578)2.74070797
92negative regulation of calcium ion transport into cytosol (GO:0010523)2.73369408
93auditory behavior (GO:0031223)2.72948328
94dendrite development (GO:0016358)2.72002985
95male sex determination (GO:0030238)2.71931480
96neuronal action potential (GO:0019228)2.71404014
97isoprenoid biosynthetic process (GO:0008299)2.71348825
98negative regulation of osteoblast proliferation (GO:0033689)2.70669431
99protein polyglutamylation (GO:0018095)2.70592240
100regulation of synapse assembly (GO:0051963)2.68989007
101water-soluble vitamin biosynthetic process (GO:0042364)2.68888082
102regulation of mesoderm development (GO:2000380)2.68725481
103negative regulation by host of viral transcription (GO:0043922)2.67668694
104protein-cofactor linkage (GO:0018065)2.67584356
105indolalkylamine metabolic process (GO:0006586)2.67181555
106behavioral response to ethanol (GO:0048149)2.66235027
107primary amino compound metabolic process (GO:1901160)2.65814867
108positive regulation of action potential (GO:0045760)2.64352293
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63264682
110developmental pigmentation (GO:0048066)2.63209311
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62167084
112keratinocyte development (GO:0003334)2.59524128
113neural nucleus development (GO:0048857)2.58881594
114gamma-aminobutyric acid transport (GO:0015812)2.57393012
115preassembly of GPI anchor in ER membrane (GO:0016254)2.56960193
116detection of light stimulus involved in sensory perception (GO:0050962)2.56109750
117detection of light stimulus involved in visual perception (GO:0050908)2.56109750
118cellular ketone body metabolic process (GO:0046950)2.55682066
119axon development (GO:0061564)2.55261346
120endoderm formation (GO:0001706)2.55192405
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54999170
122regulation of action potential (GO:0098900)2.54787979
123organ growth (GO:0035265)2.54517994
124regulation of synapse structural plasticity (GO:0051823)2.53934663
125cranial nerve development (GO:0021545)2.52964880
126negative regulation of axonogenesis (GO:0050771)2.52899822
127kynurenine metabolic process (GO:0070189)2.52691414
128regulation of cilium movement (GO:0003352)2.52465260
129secondary metabolite biosynthetic process (GO:0044550)2.52046806
130respiratory electron transport chain (GO:0022904)2.51630568
131positive regulation of protein tyrosine kinase activity (GO:0061098)2.51143656
132ganglioside metabolic process (GO:0001573)2.50978614
133dendritic spine organization (GO:0097061)2.50462988
134cilium movement (GO:0003341)2.50339763
135indolalkylamine catabolic process (GO:0046218)2.50030166
136tryptophan catabolic process (GO:0006569)2.50030166
137indole-containing compound catabolic process (GO:0042436)2.50030166
138regulation of dendritic spine development (GO:0060998)2.49889158
139negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49689645
140negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49055943
141regulation of microtubule-based movement (GO:0060632)2.48875620
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48764381
143myelin assembly (GO:0032288)2.48122842
144serotonin metabolic process (GO:0042428)2.48014370
145anatomical structure arrangement (GO:0048532)2.47923286
146reflex (GO:0060004)2.47614647
147regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47503300
148startle response (GO:0001964)2.46869986
149axoneme assembly (GO:0035082)2.46752557
150lymphoid progenitor cell differentiation (GO:0002320)2.46443665
151viral transcription (GO:0019083)2.46439092
152alanine transport (GO:0032328)2.46250003
153ketone body metabolic process (GO:1902224)2.45854271
154regulation of dopamine metabolic process (GO:0042053)2.45562141
155regulation of catecholamine metabolic process (GO:0042069)2.45562141
156positive regulation of neurological system process (GO:0031646)2.45270120
157cell differentiation in spinal cord (GO:0021515)2.45095380
158renal tubule morphogenesis (GO:0061333)2.44595952
159regulation of synapse maturation (GO:0090128)2.44116815
160photoreceptor cell development (GO:0042461)2.44067611
161regulation of inositol phosphate biosynthetic process (GO:0010919)2.43881043
162neuron fate determination (GO:0048664)2.43847366
163calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.43532672
164spinal cord motor neuron differentiation (GO:0021522)2.43289556
165electron transport chain (GO:0022900)2.43216600
166protein import into peroxisome matrix (GO:0016558)2.41843502
167activated T cell proliferation (GO:0050798)2.41661757
168neuronal stem cell maintenance (GO:0097150)2.41590731
169cilium morphogenesis (GO:0060271)2.41222556
170pyrimidine nucleobase catabolic process (GO:0006208)2.39925097
171positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39452924
172quinone biosynthetic process (GO:1901663)2.39210229
173translational termination (GO:0006415)2.39036695
174regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38805573
175rhodopsin mediated signaling pathway (GO:0016056)2.38592087
176neuron maturation (GO:0042551)2.38366064
177G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38354132
178regulation of telomere maintenance (GO:0032204)2.37280251
179negative regulation of execution phase of apoptosis (GO:1900118)2.36987935
180glycerophospholipid catabolic process (GO:0046475)2.36760718
181positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.36618121
182sialylation (GO:0097503)2.36515974
183cell proliferation in forebrain (GO:0021846)2.36322944
184negative regulation of oligodendrocyte differentiation (GO:0048715)2.36170453
185synaptic transmission, glutamatergic (GO:0035249)2.35872964
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.35313787
187indole-containing compound metabolic process (GO:0042430)2.34158986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94480929
2GBX2_23144817_ChIP-Seq_PC3_Human3.99574278
3ZNF274_21170338_ChIP-Seq_K562_Hela3.98980348
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03164592
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96673522
6TAF15_26573619_Chip-Seq_HEK293_Human2.76206789
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74953920
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.65141063
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56695829
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48805256
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48805256
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46764090
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42133742
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.41083559
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40273874
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36933760
17AR_21572438_ChIP-Seq_LNCaP_Human2.33915657
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32410687
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31391961
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28018183
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25575038
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.22227565
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21938599
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13367153
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11944330
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.11189346
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.08363988
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.08007630
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04048195
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99334485
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98774428
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95752372
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94763822
34P300_19829295_ChIP-Seq_ESCs_Human1.92910295
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92593793
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89722217
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89490336
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88979626
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87506030
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79128423
41VDR_22108803_ChIP-Seq_LS180_Human1.78701337
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77920193
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74660640
44IRF1_19129219_ChIP-ChIP_H3396_Human1.74351114
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72958832
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.72698752
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.70619632
48ER_23166858_ChIP-Seq_MCF-7_Human1.65817640
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.65420327
50MYC_18940864_ChIP-ChIP_HL60_Human1.64151302
51IGF1R_20145208_ChIP-Seq_DFB_Human1.63330806
52FUS_26573619_Chip-Seq_HEK293_Human1.61917440
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57254130
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.51001802
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49872473
56TP53_22573176_ChIP-Seq_HFKS_Human1.49198161
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48363673
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46187710
59SMAD4_21799915_ChIP-Seq_A2780_Human1.42697205
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39298124
61ERA_21632823_ChIP-Seq_H3396_Human1.39121135
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.39093830
63RNF2_27304074_Chip-Seq_NSC_Mouse1.36770914
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.35963976
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.34824307
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.30526913
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.30513200
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.29893153
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.28859971
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28703121
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27894441
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26663640
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26349876
74REST_21632747_ChIP-Seq_MESCs_Mouse1.26249024
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23358633
76NCOR_22424771_ChIP-Seq_293T_Human1.22699891
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.22299654
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21045527
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20839706
80MYC_19829295_ChIP-Seq_ESCs_Human1.20374348
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19116141
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18642664
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17289895
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16509964
85AHR_22903824_ChIP-Seq_MCF-7_Human1.15884780
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12584684
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12569206
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11865584
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.11657731
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11525448
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.11525448
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.11374155
93TP53_16413492_ChIP-PET_HCT116_Human1.10371748
94DROSHA_22980978_ChIP-Seq_HELA_Human1.10179111
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09826790
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09805646
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.09708028
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09675824
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09399613
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08096075
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.07583814
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06976674
103P300_18555785_Chip-Seq_ESCs_Mouse1.06942406
104KDM2B_26808549_Chip-Seq_REH_Human1.06631901
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06053018
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.05578926
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05540720
108NANOG_20526341_ChIP-Seq_ESCs_Human1.05139317
109P53_22387025_ChIP-Seq_ESCs_Mouse1.04915715
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.04657662
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.04248922
112TAF2_19829295_ChIP-Seq_ESCs_Human1.03835960
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03639008
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03587687
115HOXB7_26014856_ChIP-Seq_BT474_Human1.02640829
116RUNX2_22187159_ChIP-Seq_PCA_Human1.02071103
117EWS_26573619_Chip-Seq_HEK293_Human1.01918953
118TP53_18474530_ChIP-ChIP_U2OS_Human1.01908489
119STAT3_23295773_ChIP-Seq_U87_Human1.01776198
120SOX2_19829295_ChIP-Seq_ESCs_Human1.01576466
121NANOG_19829295_ChIP-Seq_ESCs_Human1.01576466
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01418724
123TCF4_22108803_ChIP-Seq_LS180_Human1.00578643
124P53_21459846_ChIP-Seq_SAOS-2_Human1.00089030
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99129853
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98254437
127CBP_20019798_ChIP-Seq_JUKART_Human0.98254437
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.96801298
129AR_20517297_ChIP-Seq_VCAP_Human0.96742402
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96519325
131TAL1_26923725_Chip-Seq_HPCs_Mouse0.96327856
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96252929
133CTCF_27219007_Chip-Seq_Bcells_Human0.95326164
134TCF4_23295773_ChIP-Seq_U87_Human0.94642464
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.92507750
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92438703
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.92079229
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91949990
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91949990
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91946621
141AR_25329375_ChIP-Seq_VCAP_Human0.91395310
142BCAT_22108803_ChIP-Seq_LS180_Human0.91126879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.21644774
2MP0000920_abnormal_myelination3.96447844
3MP0004272_abnormal_basement_membrane3.82664400
4MP0003880_abnormal_central_pattern3.81501858
5MP0004381_abnormal_hair_follicle3.37398964
6MP0001968_abnormal_touch/_nociception3.16562463
7MP0005409_darkened_coat_color2.98213962
8MP0004147_increased_porphyrin_level2.70962471
9MP0002272_abnormal_nervous_system2.50243531
10MP0008877_abnormal_DNA_methylation2.49759236
11MP0009046_muscle_twitch2.38390357
12MP0004145_abnormal_muscle_electrophysio2.36238356
13MP0005171_absent_coat_pigmentation2.36040258
14MP0001188_hyperpigmentation2.28799228
15MP0002653_abnormal_ependyma_morphology2.26811252
16MP0004270_analgesia2.23141044
17MP0003634_abnormal_glial_cell2.22714867
18MP0002734_abnormal_mechanical_nocicepti2.17420005
19MP0003045_fibrosis2.12104759
20MP0002067_abnormal_sensory_capabilities2.10067060
21MP0004133_heterotaxia2.04833494
22MP0005423_abnormal_somatic_nervous2.04519077
23MP0003195_calcinosis2.02707067
24MP0001486_abnormal_startle_reflex2.01381492
25MP0006276_abnormal_autonomic_nervous2.00941761
26MP0004142_abnormal_muscle_tone1.94604789
27MP0008260_abnormal_autophagy1.91682496
28MP0000751_myopathy1.90561516
29MP0000778_abnormal_nervous_system1.90051804
30MP0002064_seizures1.89064333
31MP0009379_abnormal_foot_pigmentation1.82993265
32MP0003315_abnormal_perineum_morphology1.81798953
33MP0003950_abnormal_plasma_membrane1.81577790
34MP0005075_abnormal_melanosome_morpholog1.79868530
35MP0005174_abnormal_tail_pigmentation1.78450098
36MP0003635_abnormal_synaptic_transmissio1.77223863
37MP0001661_extended_life_span1.76270284
38MP0003787_abnormal_imprinting1.74951631
39MP0008438_abnormal_cutaneous_collagen1.72530670
40MP0008872_abnormal_physiological_respon1.71892661
41MP0002736_abnormal_nociception_after1.69562253
42MP0008875_abnormal_xenobiotic_pharmacok1.67384954
43MP0002733_abnormal_thermal_nociception1.66198668
44MP0003878_abnormal_ear_physiology1.62716440
45MP0005377_hearing/vestibular/ear_phenot1.62716440
46MP0004742_abnormal_vestibular_system1.60561807
47MP0003283_abnormal_digestive_organ1.60013928
48MP0005408_hypopigmentation1.56080830
49MP0009745_abnormal_behavioral_response1.56006200
50MP0001348_abnormal_lacrimal_gland1.55875450
51MP0008569_lethality_at_weaning1.55411838
52MP0006072_abnormal_retinal_apoptosis1.53487786
53MP0003632_abnormal_nervous_system1.52880092
54MP0001986_abnormal_taste_sensitivity1.51675142
55MP0002572_abnormal_emotion/affect_behav1.50152267
56MP0002938_white_spotting1.49718969
57MP0008995_early_reproductive_senescence1.47544047
58MP0004859_abnormal_synaptic_plasticity1.45016207
59MP0005623_abnormal_meninges_morphology1.44738069
60MP0004885_abnormal_endolymph1.42076516
61MP0000372_irregular_coat_pigmentation1.41805016
62MP0001970_abnormal_pain_threshold1.38513217
63MP0002557_abnormal_social/conspecific_i1.37746256
64MP0005084_abnormal_gallbladder_morpholo1.35348896
65MP0002876_abnormal_thyroid_physiology1.33251624
66MP0001905_abnormal_dopamine_level1.31404351
67MP0003646_muscle_fatigue1.30608591
68MP0000747_muscle_weakness1.30116631
69MP0002751_abnormal_autonomic_nervous1.29611185
70MP0003011_delayed_dark_adaptation1.27880659
71MP0002928_abnormal_bile_duct1.26360909
72MP0002184_abnormal_innervation1.26144955
73MP0002160_abnormal_reproductive_system1.25562409
74MP0000566_synostosis1.25365696
75MP0002735_abnormal_chemical_nociception1.23913838
76MP0003329_amyloid_beta_deposits1.22604089
77MP0004858_abnormal_nervous_system1.22341312
78MP0001529_abnormal_vocalization1.21893997
79MP0003631_nervous_system_phenotype1.20945246
80MP0000462_abnormal_digestive_system1.17037693
81MP0002063_abnormal_learning/memory/cond1.16164130
82MP0001963_abnormal_hearing_physiology1.16030376
83MP0005389_reproductive_system_phenotype1.15404592
84MP0001440_abnormal_grooming_behavior1.13639498
85MP0000749_muscle_degeneration1.10588141
86MP0002882_abnormal_neuron_morphology1.06749291
87MP0002229_neurodegeneration1.05581679
88MP0001502_abnormal_circadian_rhythm1.04868927
89MP0009384_cardiac_valve_regurgitation1.04545998
90MP0002752_abnormal_somatic_nervous1.02135409
91MP0001324_abnormal_eye_pigmentation1.02057048
92MP0000569_abnormal_digit_pigmentation1.01849760
93MP0001485_abnormal_pinna_reflex1.01291257
94MP0000013_abnormal_adipose_tissue1.01026141
95MP0003119_abnormal_digestive_system1.00989735
96MP0002066_abnormal_motor_capabilities/c0.99665747
97MP0001293_anophthalmia0.98121434
98MP0003690_abnormal_glial_cell0.97751185
99MP0001919_abnormal_reproductive_system0.96288427
100MP0003633_abnormal_nervous_system0.95017731
101MP0000955_abnormal_spinal_cord0.93255723
102MP0005551_abnormal_eye_electrophysiolog0.92321434
103MP0000026_abnormal_inner_ear0.92299781
104MP0002168_other_aberrant_phenotype0.91726228
105MP0004043_abnormal_pH_regulation0.91478007
106MP0010030_abnormal_orbit_morphology0.90866159
107MP0006292_abnormal_olfactory_placode0.89198134
108MP0000049_abnormal_middle_ear0.88703365
109MP0001501_abnormal_sleep_pattern0.88455131
110MP0002163_abnormal_gland_morphology0.88305030
111MP0002102_abnormal_ear_morphology0.88149158
112MP0002009_preneoplasia0.86198154
113MP0003137_abnormal_impulse_conducting0.84594250
114MP0002837_dystrophic_cardiac_calcinosis0.84435987
115MP0002095_abnormal_skin_pigmentation0.84396122
116MP0008789_abnormal_olfactory_epithelium0.84050238
117MP0005391_vision/eye_phenotype0.79656705
118MP0002210_abnormal_sex_determination0.78751133
119MP0002234_abnormal_pharynx_morphology0.77549944
120MP0005448_abnormal_energy_balance0.76758532
121MP0001984_abnormal_olfaction0.76625726
122MP0000015_abnormal_ear_pigmentation0.76609359
123MP0000230_abnormal_systemic_arterial0.76416546
124MP0003698_abnormal_male_reproductive0.75414896
125MP0003938_abnormal_ear_development0.74176534
126MP0000383_abnormal_hair_follicle0.73533355
127MP0002277_abnormal_respiratory_mucosa0.73175021
128MP0000750_abnormal_muscle_regeneration0.73069629
129MP0003890_abnormal_embryonic-extraembry0.72366000
130MP0002822_catalepsy0.71806575
131MP0002638_abnormal_pupillary_reflex0.70521882
132MP0003122_maternal_imprinting0.68437525
133MP0003385_abnormal_body_wall0.67849562
134MP0005253_abnormal_eye_physiology0.67538447
135MP0001186_pigmentation_phenotype0.64832051
136MP0005503_abnormal_tendon_morphology0.64023237
137MP0004811_abnormal_neuron_physiology0.63256466
138MP0005645_abnormal_hypothalamus_physiol0.63105267
139MP0005646_abnormal_pituitary_gland0.61901970
140MP0000631_abnormal_neuroendocrine_gland0.60891891
141MP0002152_abnormal_brain_morphology0.60042967
142MP0005386_behavior/neurological_phenoty0.59625526
143MP0004924_abnormal_behavior0.59625526
144MP0005195_abnormal_posterior_eye0.59278208
145MP0005379_endocrine/exocrine_gland_phen0.59048875

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)8.72836584
2Insidious onset (HP:0003587)8.72836584
3Impaired proprioception (HP:0010831)8.06847186
4Action tremor (HP:0002345)6.61283046
5Peripheral hypomyelination (HP:0007182)6.08968493
6Onion bulb formation (HP:0003383)5.42127095
7Steppage gait (HP:0003376)5.31162553
8Upper limb muscle weakness (HP:0003484)5.30914499
9Increased CSF protein (HP:0002922)4.92537491
10Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.84526038
11Abnormal pupillary function (HP:0007686)4.78955189
12Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.66089501
13Pancreatic cysts (HP:0001737)4.35084278
14Molar tooth sign on MRI (HP:0002419)4.30235179
15Abnormality of midbrain morphology (HP:0002418)4.30235179
16Pancreatic fibrosis (HP:0100732)4.27382930
17Congenital stationary night blindness (HP:0007642)4.21747830
18Decreased motor nerve conduction velocity (HP:0003431)4.12304971
19Abnormality of the vocal cords (HP:0008777)4.06867852
20True hermaphroditism (HP:0010459)4.06092846
21Postural tremor (HP:0002174)3.97150106
22Hammertoe (HP:0001765)3.94144707
23Peripheral demyelination (HP:0011096)3.76256718
24Foot dorsiflexor weakness (HP:0009027)3.67831005
25Nephronophthisis (HP:0000090)3.59171624
26Hypomagnesemia (HP:0002917)3.54423801
27Abnormality of the foot musculature (HP:0001436)3.40081441
28Abnormal number of erythroid precursors (HP:0012131)3.35676589
29Type II lissencephaly (HP:0007260)3.27529705
30Sex reversal (HP:0012245)3.22863318
31Abnormal sex determination (HP:0012244)3.22863318
32Abnormality of the renal medulla (HP:0100957)3.22401270
33Abnormality of cells of the erythroid lineage (HP:0012130)3.09125886
34Cystic liver disease (HP:0006706)3.03379079
35Abnormal auditory evoked potentials (HP:0006958)3.01467437
36Abnormality of the renal cortex (HP:0011035)2.97081039
37Tubular atrophy (HP:0000092)2.91805208
38Hypoplasia of the uterus (HP:0000013)2.90179564
39Polydipsia (HP:0001959)2.85206418
40Abnormal drinking behavior (HP:0030082)2.85206418
41Focal motor seizures (HP:0011153)2.84043537
42Pendular nystagmus (HP:0012043)2.79232668
43Progressive sensorineural hearing impairment (HP:0000408)2.75724229
44Parakeratosis (HP:0001036)2.73003545
45Abnormality of magnesium homeostasis (HP:0004921)2.70125797
46Sclerocornea (HP:0000647)2.66625160
47Attenuation of retinal blood vessels (HP:0007843)2.66591866
48Rib fusion (HP:0000902)2.65742861
49Aplasia cutis congenita (HP:0001057)2.65125858
50Abnormal rod and cone electroretinograms (HP:0008323)2.62914837
51Chronic hepatic failure (HP:0100626)2.61720972
52Atrophic scars (HP:0001075)2.60957382
53Medial flaring of the eyebrow (HP:0010747)2.58819781
54Abnormality of calcium-phosphate metabolism (HP:0100530)2.58212539
55Patellar aplasia (HP:0006443)2.55869747
56Aplasia/hypoplasia of the uterus (HP:0008684)2.55183342
57Congenital, generalized hypertrichosis (HP:0004540)2.53918283
58Birth length less than 3rd percentile (HP:0003561)2.48735732
59Aplasia/Hypoplasia of the patella (HP:0006498)2.43803962
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43259745
61Large for gestational age (HP:0001520)2.39953834
62Concave nail (HP:0001598)2.36784532
63Cerebellar dysplasia (HP:0007033)2.34806490
64Polyuria (HP:0000103)2.34237780
65Male pseudohermaphroditism (HP:0000037)2.28097996
66Progressive cerebellar ataxia (HP:0002073)2.24826161
67Congenital hepatic fibrosis (HP:0002612)2.24326295
68Neurofibrillary tangles (HP:0002185)2.23447243
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22121414
70Gait imbalance (HP:0002141)2.21023076
71Anencephaly (HP:0002323)2.20779965
72Septo-optic dysplasia (HP:0100842)2.18953829
73Optic nerve hypoplasia (HP:0000609)2.16779053
74Genetic anticipation (HP:0003743)2.16268280
75Inability to walk (HP:0002540)2.14595243
76Acute necrotizing encephalopathy (HP:0006965)2.14077653
77Distal sensory impairment (HP:0002936)2.13712225
78Fragile skin (HP:0001030)2.13039647
79Abolished electroretinogram (ERG) (HP:0000550)2.11194066
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09726206
81Bile duct proliferation (HP:0001408)2.09460968
82Abnormal biliary tract physiology (HP:0012439)2.09460968
83Decreased central vision (HP:0007663)2.07130827
84Furrowed tongue (HP:0000221)2.04820325
85Retinal dysplasia (HP:0007973)2.03598741
86Anophthalmia (HP:0000528)2.03252762
87Mesangial abnormality (HP:0001966)2.01705708
88Ulnar claw (HP:0001178)12.6685547
89Segmental peripheral demyelination/remyelination (HP:0003481)10.6679273
90Congenital primary aphakia (HP:0007707)1.99364788
91Stomach cancer (HP:0012126)1.94936890
92Atonic seizures (HP:0010819)1.94087678
93Akinesia (HP:0002304)1.92007075
94Abnormality of the pons (HP:0007361)1.91030000
95Infantile muscular hypotonia (HP:0008947)1.90982958
96Hypoplasia of the pons (HP:0012110)1.89860833
97Occipital encephalocele (HP:0002085)1.89753014
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.89495528
99Absent/shortened dynein arms (HP:0200106)1.89495528
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.88796465
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.87858120
102Abnormal urine output (HP:0012590)1.87527374
103Progressive macrocephaly (HP:0004481)1.87087967
104Submucous cleft hard palate (HP:0000176)1.85730183
105Severe muscular hypotonia (HP:0006829)1.84676851
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84476327
107Postaxial foot polydactyly (HP:0001830)1.84417283
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.83654755
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83654755
110Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82485537
111Nephrogenic diabetes insipidus (HP:0009806)1.82270322
112Lissencephaly (HP:0001339)1.82002606
113Sensory axonal neuropathy (HP:0003390)1.80880049
114Mitochondrial inheritance (HP:0001427)1.80767007
115Bony spicule pigmentary retinopathy (HP:0007737)1.79465109
116Increased corneal curvature (HP:0100692)1.78306731
117Keratoconus (HP:0000563)1.78306731
118Bilateral microphthalmos (HP:0007633)1.77591636
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.76739840
120Clumsiness (HP:0002312)1.76494817
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76442248
122Abnormality of alanine metabolism (HP:0010916)1.76442248
123Hyperalaninemia (HP:0003348)1.76442248
124Congenital sensorineural hearing impairment (HP:0008527)1.76265115
125Alacrima (HP:0000522)1.76184430
126White forelock (HP:0002211)1.75922381
127Hemiparesis (HP:0001269)1.75799421
128Hypoplastic ischia (HP:0003175)1.75234992
129Hyperglycinemia (HP:0002154)1.72391214
130Tachypnea (HP:0002789)1.72285675
131Patchy hypopigmentation of hair (HP:0011365)1.72279428
132Progressive hearing impairment (HP:0001730)1.71853009
133Chorioretinal atrophy (HP:0000533)1.69577491
134Kyphoscoliosis (HP:0002751)1.69234249
135Hypoplasia of the fovea (HP:0007750)1.68765266
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.68765266
137Oligodactyly (hands) (HP:0001180)1.67021813
138Abnormal ciliary motility (HP:0012262)1.66870299
139Renal cortical cysts (HP:0000803)1.66411018
140Hepatocellular necrosis (HP:0001404)1.65150799
141Abnormality of renal excretion (HP:0011036)1.65077727
142Increased hepatocellular lipid droplets (HP:0006565)1.65005308
143Asplenia (HP:0001746)1.64685164
144Focal seizures (HP:0007359)1.64048293
145Cerebral inclusion bodies (HP:0100314)1.63979080
146Abnormal mitochondria in muscle tissue (HP:0008316)1.60745533
147Broad-based gait (HP:0002136)1.58038681
148Renal Fanconi syndrome (HP:0001994)1.57929806
149Abnormality of the pupil (HP:0000615)1.56698484
150Narrow nasal bridge (HP:0000446)1.54669948
151Epileptic encephalopathy (HP:0200134)1.54478797
152Limb dystonia (HP:0002451)1.53607429
153Acute encephalopathy (HP:0006846)1.53230032
154Hyperventilation (HP:0002883)1.52631237
155Pheochromocytoma (HP:0002666)1.50025917
156Optic disc pallor (HP:0000543)1.45904470
157Soft skin (HP:0000977)1.45788072
158Abnormality of the corticospinal tract (HP:0002492)1.45205432
159Neuroendocrine neoplasm (HP:0100634)1.44929969
160Premature rupture of membranes (HP:0001788)1.44406296
161Gonadal dysgenesis (HP:0000133)1.43724293
162Venous insufficiency (HP:0005293)1.42833195
163Hypoplasia of the iris (HP:0007676)1.42771792
164Morphological abnormality of the middle ear (HP:0008609)1.42070776
165Leukodystrophy (HP:0002415)1.39060051
166Increased CSF lactate (HP:0002490)1.38214963
167Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.37998460
168Decreased lacrimation (HP:0000633)1.37196785
169Esophageal atresia (HP:0002032)1.35897518
170Abnormal respiratory motile cilium morphology (HP:0005938)1.34987897
171Abnormal respiratory epithelium morphology (HP:0012253)1.34987897
172Agitation (HP:0000713)1.34718771
173Blue irides (HP:0000635)1.33936481
174Esotropia (HP:0000565)1.32635461
175Myelomeningocele (HP:0002475)1.31482344
176Abnormality of renal resorption (HP:0011038)1.31469790
177Supranuclear gaze palsy (HP:0000605)1.31269860
178Exotropia (HP:0000577)1.30276051
179Difficulty walking (HP:0002355)1.29043064
180Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.27489145
181Respiratory failure (HP:0002878)1.26556477
182Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.26488718
183Thickened helices (HP:0000391)1.26253081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK24.20553420
2IRAK13.92014060
3STK393.77930813
4CASK3.63080497
5FRK2.96150967
6TNIK2.86309698
7UHMK12.50934172
8PINK12.46344460
9ZAK2.39713948
10OXSR12.37259617
11ACVR1B2.31093659
12WNK32.22895209
13MST42.09617569
14BLK2.09561649
15WNK42.07332837
16MAP4K21.90988315
17TAOK31.88475487
18STK161.87041420
19MAP2K61.84086998
20YES11.77954666
21TLK11.77817825
22CDK191.77241117
23PNCK1.75195531
24MKNK21.73652102
25PRPF4B1.68475720
26WEE11.59050016
27MUSK1.56849301
28EPHB11.55648505
29TSSK61.51885288
30PKN11.51485650
31MARK21.51365575
32TXK1.49883468
33NTRK31.45676313
34DAPK21.43502783
35TGFBR11.43135873
36NME11.40053287
37EPHA41.39704741
38IRAK41.37686045
39RIPK41.30843181
40MAPK131.30323988
41MARK11.27569337
42MAP2K71.26085628
43GRK71.23569452
44MAPKAPK31.21793877
45TYRO31.17897785
46FGR1.14477277
47PIK3CA1.13147376
48EPHB21.11203039
49PTK2B1.09916898
50FES1.08790221
51CLK11.01844153
52CAMK2B1.01804640
53BCR1.00548058
54PLK20.99586368
55CAMK2A0.99160157
56CDK50.95650429
57ROCK20.94150449
58ARAF0.93396059
59MKNK10.92233919
60GRK50.91283328
61NEK20.90946211
62MAPKAPK50.88026759
63MAP3K40.87020962
64MAP3K120.84117184
65FGFR20.84013388
66INSRR0.83391429
67VRK10.81649335
68CAMK2D0.80134948
69WNK10.76440810
70CAMK1D0.75672648
71CSNK1G30.74921472
72VRK20.74626536
73BMPR20.73940938
74NTRK10.71963753
75RPS6KA50.71912777
76BMPR1B0.71054475
77PHKG20.71030206
78PHKG10.71030206
79PRKCQ0.70423671
80PAK60.70270844
81DYRK20.69827313
82BCKDK0.68735532
83NTRK20.68549842
84RPS6KA60.68509522
85BRAF0.67379789
86CSNK1G10.67108389
87ADRBK10.66974861
88ITK0.66255569
89PRKCE0.65486486
90SIK20.64057822
91PBK0.62569979
92CSNK1G20.62322553
93KDR0.60862057
94MAP3K110.60291126
95CAMKK10.59982969
96AKT30.59540412
97CSNK1A1L0.58659693
98LIMK10.58089939
99FYN0.57897999
100DYRK1A0.56986055
101ERBB20.56357175
102PRKD30.54995052
103CAMK10.54161745
104MAPK150.52725404
105MINK10.52220004
106PRKCG0.51144725
107SGK4940.50653851
108SGK2230.50653851
109TEC0.49157162
110DYRK30.48978389
111ADRBK20.48710237
112MARK30.48503410
113NUAK10.47734983
114PRKCI0.47655944
115PLK40.47424890
116CDK140.46671260
117CDK30.46130277
118CHEK20.46123025
119MOS0.45714746
120ICK0.45080069
121CAMKK20.44937709
122TNK20.44734666
123DYRK1B0.43801419
124BRSK20.43771621
125CSK0.43304434
126CAMK1G0.41989871
127CAMK2G0.41558978
128PASK0.40597590
129MAP2K20.40282543
130PRKACA0.39934523
131MET0.38917971
132MAP2K10.38851358
133KIT0.38762216
134PRKG10.38700074
135ROCK10.38581418
136LCK0.38306864
137SRPK10.38217319
138PRKD20.37647221
139MAP2K40.35936826
140TIE10.35783700
141STK110.35090845
142GRK10.34739808
143PRKCZ0.34361699
144IKBKB0.33885776
145PAK30.33795698
146CDK180.33224902
147MAP3K70.31557628
148PRKCA0.28069539
149PIM10.27113098
150ATR0.26281890
151PRKAA10.26217783
152PRKCH0.26212670

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.39934760
2Oxidative phosphorylation_Homo sapiens_hsa001903.07640914
3Nicotine addiction_Homo sapiens_hsa050333.01840597
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.83276193
5Linoleic acid metabolism_Homo sapiens_hsa005912.78036952
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.75318891
7Nitrogen metabolism_Homo sapiens_hsa009102.74972485
8Fatty acid elongation_Homo sapiens_hsa000622.66953866
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.45909103
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.36866986
11Steroid biosynthesis_Homo sapiens_hsa001002.34105139
12Alzheimers disease_Homo sapiens_hsa050102.28829752
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28299448
14Parkinsons disease_Homo sapiens_hsa050122.26197716
15Axon guidance_Homo sapiens_hsa043602.21904237
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16751851
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.16419161
18Homologous recombination_Homo sapiens_hsa034401.93605127
19Protein export_Homo sapiens_hsa030601.90610963
20Serotonergic synapse_Homo sapiens_hsa047261.88020400
21Glutamatergic synapse_Homo sapiens_hsa047241.82086503
22Selenocompound metabolism_Homo sapiens_hsa004501.76352855
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76172361
24ECM-receptor interaction_Homo sapiens_hsa045121.72415000
25Fanconi anemia pathway_Homo sapiens_hsa034601.69237947
26Ether lipid metabolism_Homo sapiens_hsa005651.67106234
27Huntingtons disease_Homo sapiens_hsa050161.61916924
28Long-term depression_Homo sapiens_hsa047301.61709064
29GABAergic synapse_Homo sapiens_hsa047271.52388347
30Morphine addiction_Homo sapiens_hsa050321.51363647
31Taste transduction_Homo sapiens_hsa047421.50159327
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46816550
33Sulfur relay system_Homo sapiens_hsa041221.46188818
34Sphingolipid metabolism_Homo sapiens_hsa006001.45922972
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45814771
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43574151
37Circadian entrainment_Homo sapiens_hsa047131.37233785
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30832573
39Basal transcription factors_Homo sapiens_hsa030221.29743902
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28717029
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28002186
42Cardiac muscle contraction_Homo sapiens_hsa042601.27485284
43Olfactory transduction_Homo sapiens_hsa047401.24121716
44Cholinergic synapse_Homo sapiens_hsa047251.23371422
45Collecting duct acid secretion_Homo sapiens_hsa049661.22435044
46Long-term potentiation_Homo sapiens_hsa047201.19367520
47Synaptic vesicle cycle_Homo sapiens_hsa047211.14859963
48Phototransduction_Homo sapiens_hsa047441.14228062
49Dopaminergic synapse_Homo sapiens_hsa047281.14036517
50Tryptophan metabolism_Homo sapiens_hsa003801.12653685
51ABC transporters_Homo sapiens_hsa020101.08719567
52Salivary secretion_Homo sapiens_hsa049701.07298354
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00641766
54One carbon pool by folate_Homo sapiens_hsa006700.99891078
55Dilated cardiomyopathy_Homo sapiens_hsa054140.97426564
56RNA degradation_Homo sapiens_hsa030180.96462832
57Amphetamine addiction_Homo sapiens_hsa050310.95476295
58Dorso-ventral axis formation_Homo sapiens_hsa043200.94657098
59Peroxisome_Homo sapiens_hsa041460.93990545
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93923417
61Caffeine metabolism_Homo sapiens_hsa002320.93298198
62Renin secretion_Homo sapiens_hsa049240.92627231
63Ribosome_Homo sapiens_hsa030100.92351684
64Basal cell carcinoma_Homo sapiens_hsa052170.91938605
65Regulation of autophagy_Homo sapiens_hsa041400.91041534
66Fat digestion and absorption_Homo sapiens_hsa049750.90858725
67African trypanosomiasis_Homo sapiens_hsa051430.88753787
68Calcium signaling pathway_Homo sapiens_hsa040200.88657717
69Cocaine addiction_Homo sapiens_hsa050300.84856333
70Propanoate metabolism_Homo sapiens_hsa006400.84770040
71Gastric acid secretion_Homo sapiens_hsa049710.84409248
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.81087339
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81037229
74Ras signaling pathway_Homo sapiens_hsa040140.80952156
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80432516
76Chemical carcinogenesis_Homo sapiens_hsa052040.79267912
77Hedgehog signaling pathway_Homo sapiens_hsa043400.76909649
78Gap junction_Homo sapiens_hsa045400.76651770
79Retinol metabolism_Homo sapiens_hsa008300.76011283
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75966573
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.75893312
82Alcoholism_Homo sapiens_hsa050340.75133831
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74967925
84Histidine metabolism_Homo sapiens_hsa003400.74170718
85Viral myocarditis_Homo sapiens_hsa054160.74020969
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73379939
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72635638
88Melanogenesis_Homo sapiens_hsa049160.70958714
89Rheumatoid arthritis_Homo sapiens_hsa053230.70233424
90Vibrio cholerae infection_Homo sapiens_hsa051100.70212171
91Renal cell carcinoma_Homo sapiens_hsa052110.69978600
92Insulin secretion_Homo sapiens_hsa049110.68763206
93Focal adhesion_Homo sapiens_hsa045100.68027634
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66923832
95Oxytocin signaling pathway_Homo sapiens_hsa049210.65931978
96Protein digestion and absorption_Homo sapiens_hsa049740.65474893
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.65151663
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64813832
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.63885531
100ErbB signaling pathway_Homo sapiens_hsa040120.61479498
101Metabolic pathways_Homo sapiens_hsa011000.59109957
102Purine metabolism_Homo sapiens_hsa002300.58496674
103Glycerolipid metabolism_Homo sapiens_hsa005610.58212173
104Prion diseases_Homo sapiens_hsa050200.58134673
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55787967
106RNA polymerase_Homo sapiens_hsa030200.55714052
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55703632
108Pyrimidine metabolism_Homo sapiens_hsa002400.55131914
109Vitamin digestion and absorption_Homo sapiens_hsa049770.54696748
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54204196
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53508757
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.52645694
113GnRH signaling pathway_Homo sapiens_hsa049120.51990926
114beta-Alanine metabolism_Homo sapiens_hsa004100.51586909
115Estrogen signaling pathway_Homo sapiens_hsa049150.50854415
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48737494
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.47758740
118Wnt signaling pathway_Homo sapiens_hsa043100.46965334
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46684880
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45892814
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45864671
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.45345314
123Tight junction_Homo sapiens_hsa045300.44731549
124Pancreatic secretion_Homo sapiens_hsa049720.44366507
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44110953
126Phagosome_Homo sapiens_hsa041450.43574871
127Arachidonic acid metabolism_Homo sapiens_hsa005900.43137174
128Sulfur metabolism_Homo sapiens_hsa009200.42871020
129Tyrosine metabolism_Homo sapiens_hsa003500.42684225
130Autoimmune thyroid disease_Homo sapiens_hsa053200.42675935
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.42123869
132Amoebiasis_Homo sapiens_hsa051460.41331747
133Bile secretion_Homo sapiens_hsa049760.40787290
134Ovarian steroidogenesis_Homo sapiens_hsa049130.40310528
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40073827
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39999622
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39760804
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39711269
139cAMP signaling pathway_Homo sapiens_hsa040240.39658502
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37082835
141Melanoma_Homo sapiens_hsa052180.37016600
142Proteasome_Homo sapiens_hsa030500.36403247
143Rap1 signaling pathway_Homo sapiens_hsa040150.34827637
144Nucleotide excision repair_Homo sapiens_hsa034200.34097989
145MAPK signaling pathway_Homo sapiens_hsa040100.34036516
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33804033
147Chemokine signaling pathway_Homo sapiens_hsa040620.32197545
148Prostate cancer_Homo sapiens_hsa052150.31399392
149Butanoate metabolism_Homo sapiens_hsa006500.31204836
150Primary immunodeficiency_Homo sapiens_hsa053400.29783486

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