EGLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.41554424
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.27069977
3cardiac myofibril assembly (GO:0055003)7.11123455
4negative regulation of potassium ion transmembrane transport (GO:1901380)6.47564706
5myofibril assembly (GO:0030239)6.38060169
6actin-myosin filament sliding (GO:0033275)5.96548242
7muscle filament sliding (GO:0030049)5.96548242
8tricarboxylic acid cycle (GO:0006099)5.92626913
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.87630379
10plasma membrane repair (GO:0001778)5.74926127
11cardiac muscle contraction (GO:0060048)5.48606731
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.40308184
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.32491042
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.30991171
15cardiac muscle cell development (GO:0055013)5.13762350
16regulation of skeletal muscle contraction (GO:0014819)5.12812095
17carnitine shuttle (GO:0006853)5.09828545
18regulation of actin filament-based movement (GO:1903115)5.04884427
19actin-mediated cell contraction (GO:0070252)4.93154251
20actomyosin structure organization (GO:0031032)4.85607329
21cardiac cell development (GO:0055006)4.81831837
22sarcoplasmic reticulum calcium ion transport (GO:0070296)4.79970511
23regulation of acyl-CoA biosynthetic process (GO:0050812)4.76291117
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.75647483
25ventricular cardiac muscle cell action potential (GO:0086005)4.66610567
26regulation of relaxation of muscle (GO:1901077)4.62522222
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.62287775
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.60438134
29creatine metabolic process (GO:0006600)4.58341822
30regulation of cofactor metabolic process (GO:0051193)4.51328095
31regulation of coenzyme metabolic process (GO:0051196)4.51328095
32fatty acid transmembrane transport (GO:1902001)4.49314964
33striated muscle contraction (GO:0006941)4.45119546
34adult heart development (GO:0007512)4.42719315
35cardiac muscle hypertrophy (GO:0003300)4.42688436
36striated muscle hypertrophy (GO:0014897)4.25099428
37regulation of cell communication by electrical coupling (GO:0010649)4.20575819
38regulation of sequestering of triglyceride (GO:0010889)4.14787626
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.14680214
40* cardiac muscle tissue morphogenesis (GO:0055008)4.08703461
41* heart trabecula formation (GO:0060347)4.08054157
42regulation of membrane repolarization (GO:0060306)4.06742078
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.05642686
44regulation of cardioblast differentiation (GO:0051890)4.03544580
45regulation of sarcomere organization (GO:0060297)3.99919459
46cell communication involved in cardiac conduction (GO:0086065)3.95234300
47ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.93511657
48actin filament-based movement (GO:0030048)3.92400107
49regulation of striated muscle contraction (GO:0006942)3.91888357
50NADH metabolic process (GO:0006734)3.91053404
51regulation of the force of heart contraction (GO:0002026)3.80210729
52carnitine transmembrane transport (GO:1902603)3.76812326
532-oxoglutarate metabolic process (GO:0006103)3.74619171
54negative regulation of potassium ion transport (GO:0043267)3.73983602
55regulation of fatty acid oxidation (GO:0046320)3.70778505
56* muscle tissue morphogenesis (GO:0060415)3.70209827
57muscle hypertrophy (GO:0014896)3.65553442
58regulation of cardiac muscle cell contraction (GO:0086004)3.63243602
59regulation of sulfur metabolic process (GO:0042762)3.61079159
60cell communication by electrical coupling (GO:0010644)3.56335832
61detection of molecule of bacterial origin (GO:0032490)3.51990857
62cardiac muscle adaptation (GO:0014887)3.51253526
63cardiac muscle hypertrophy in response to stress (GO:0014898)3.51253526
64muscle hypertrophy in response to stress (GO:0003299)3.51253526
65amino-acid betaine transport (GO:0015838)3.49419906
66carnitine transport (GO:0015879)3.49419906
67positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.48622556
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.45897076
69negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.41232744
70macroautophagy (GO:0016236)3.34141112
71relaxation of cardiac muscle (GO:0055119)3.29862488
72heart process (GO:0003015)3.28549421
73heart contraction (GO:0060047)3.28549421
74cardiac muscle cell action potential involved in contraction (GO:0086002)3.28522558
75cardiac muscle cell action potential (GO:0086001)3.21549593
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21499361
77fatty acid beta-oxidation (GO:0006635)3.19651141
78negative regulation of striated muscle cell apoptotic process (GO:0010664)3.19532556
79regulation of cardiac muscle contraction (GO:0055117)3.17545141
80cellular response to epinephrine stimulus (GO:0071872)3.17216165
81negative regulation of protein localization to cell surface (GO:2000009)3.16623632
82muscle contraction (GO:0006936)3.16219905
83striated muscle cell development (GO:0055002)3.12345807
84skeletal muscle contraction (GO:0003009)3.11954335
85regulation of heart rate (GO:0002027)3.10412899
86regulation of calcium ion transmembrane transport (GO:1903169)3.09575585
87regulation of calcium ion transmembrane transporter activity (GO:1901019)3.09575585
88striated muscle adaptation (GO:0014888)3.05652244
89respiratory electron transport chain (GO:0022904)3.04343033
90succinate metabolic process (GO:0006105)3.03076936
91positive regulation of cation channel activity (GO:2001259)3.02222917
92glucan catabolic process (GO:0009251)3.01517409
93skeletal muscle adaptation (GO:0043501)3.00117158
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97479224
95tricarboxylic acid metabolic process (GO:0072350)2.97069660
96cardiac conduction (GO:0061337)2.96814264
97aspartate family amino acid catabolic process (GO:0009068)2.96715456
98toxin transport (GO:1901998)2.96509660
99regulation of heart contraction (GO:0008016)2.95739478
100oxidative phosphorylation (GO:0006119)2.95738952
101ATP synthesis coupled proton transport (GO:0015986)2.94762716
102energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94762716
103muscle system process (GO:0003012)2.93572880
104electron transport chain (GO:0022900)2.93039065
105ventricular cardiac muscle cell development (GO:0055015)2.92903756
106regulation of ATP catabolic process (GO:1903289)2.92858088
107regulation of ATPase activity (GO:0043462)2.92858088
108response to epinephrine (GO:0071871)2.92771771
109cellular polysaccharide catabolic process (GO:0044247)2.85478008
110response to mercury ion (GO:0046689)2.82015252
111glycogen catabolic process (GO:0005980)2.81089196
112negative regulation of necroptotic process (GO:0060546)2.80322941
113positive regulation of myotube differentiation (GO:0010831)2.78867717
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77519706
115quaternary ammonium group transport (GO:0015697)2.73356991
116positive regulation by symbiont of host defense response (GO:0052509)2.69358307
117modulation by symbiont of host defense response (GO:0052031)2.69358307
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69358307
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69358307
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.69358307
121modulation by symbiont of host immune response (GO:0052553)2.69358307
122regulation of necroptotic process (GO:0060544)2.65539693
123response to muscle activity (GO:0014850)2.63788194
124detection of external biotic stimulus (GO:0098581)2.63568611
125polysaccharide catabolic process (GO:0000272)2.52838833
126macrophage activation involved in immune response (GO:0002281)2.51381650
127response to inactivity (GO:0014854)2.50369306
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.48633277
129cellular response to fluid shear stress (GO:0071498)2.48563915
130import into cell (GO:0098657)2.47502308
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44992804
132negative regulation of cell killing (GO:0031342)2.44992804
133response to laminar fluid shear stress (GO:0034616)2.43881986
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41334474
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39706765
136relaxation of muscle (GO:0090075)2.39436411
137cellular response to catecholamine stimulus (GO:0071870)2.39412577
138cellular response to monoamine stimulus (GO:0071868)2.39412577
139positive regulation of myoblast differentiation (GO:0045663)2.38396433
140detection of other organism (GO:0098543)2.35807060
141fructose metabolic process (GO:0006000)2.35738699
142macrophage activation (GO:0042116)2.33512849
143glucan metabolic process (GO:0044042)2.32115514
144cellular glucan metabolic process (GO:0006073)2.32115514
145positive regulation of receptor recycling (GO:0001921)2.29249873
146detection of biotic stimulus (GO:0009595)2.28959499
147peptidyl-threonine phosphorylation (GO:0018107)2.24873861
148glycogen metabolic process (GO:0005977)2.24706875
149peptidyl-threonine modification (GO:0018210)2.22145188
150regulation of NFAT protein import into nucleus (GO:0051532)2.21914361
151negative regulation of necrotic cell death (GO:0060547)2.21550506
152negative regulation of complement activation (GO:0045916)2.20785896
153negative regulation of erythrocyte differentiation (GO:0045647)2.20344210
154hypotonic response (GO:0006971)2.19063228
155skeletal muscle fiber development (GO:0048741)2.18956868
156response to monoamine (GO:0071867)2.17212706
157response to catecholamine (GO:0071869)2.17212706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.30455391
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.60392283
3* EP300_21415370_ChIP-Seq_HL-1_Mouse3.27176220
4ZNF263_19887448_ChIP-Seq_K562_Human3.27139636
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.21671609
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.17805060
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.11324295
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.11324295
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88387877
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.63950247
11CLOCK_20551151_ChIP-Seq_293T_Human2.41867350
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28728239
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25138856
14GATA1_22025678_ChIP-Seq_K562_Human2.23864359
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.21600852
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.09628822
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07906311
18* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.95247794
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93980518
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.92808803
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92419733
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80548157
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77443342
24* KDM2B_26808549_Chip-Seq_DND41_Human1.75395017
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72629956
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67847055
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66354953
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66035146
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65017018
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64280198
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62388759
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.60971846
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60443331
34RACK7_27058665_Chip-Seq_MCF-7_Human1.57215699
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55356041
36* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53251525
37* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52356580
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.52261327
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50615459
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49976073
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48868534
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46791879
43* KDM2B_26808549_Chip-Seq_K562_Human1.45986686
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44148989
45RUNX_20019798_ChIP-Seq_JUKART_Human1.42836714
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41960191
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41317453
48* ATF3_27146783_Chip-Seq_COLON_Human1.40333543
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39043788
50GATA4_21415370_ChIP-Seq_HL-1_Mouse1.38243235
51* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38109565
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37952511
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.34292928
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.33866143
55EZH2_22144423_ChIP-Seq_EOC_Human1.33607939
56DROSHA_22980978_ChIP-Seq_HELA_Human1.33549419
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30818378
58LXR_22292898_ChIP-Seq_THP-1_Human1.30107895
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28066492
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.26884976
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25869868
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25869868
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25602988
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22825211
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22317790
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22267220
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22248807
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22217200
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21648727
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.21312432
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.19500778
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18341232
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.17583418
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17527269
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16905592
76* VDR_24787735_ChIP-Seq_THP-1_Human1.16872756
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.16019235
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15132614
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14618884
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14618247
81* CREB1_26743006_Chip-Seq_LNCaP_Human1.14569570
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14346321
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.13651956
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11743046
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11267915
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09308313
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08831300
88* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07758336
89* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07758336
90* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07165847
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.06938070
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06446610
93* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05312670
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04869053
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04554473
96CTCF_27219007_Chip-Seq_Bcells_Human1.04367053
97TP63_22573176_ChIP-Seq_HFKS_Human1.04174983
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04144510
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03185856
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02838216
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02671029
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02425028
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01222128
104TCF7_22412390_ChIP-Seq_EML_Mouse1.00779693
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00421168
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00286976
107RXR_22158963_ChIP-Seq_LIVER_Mouse0.99028954
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98683850
109* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98605034
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98351938
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98318145
112* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98077668
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96899156
114GATA2_19941826_ChIP-Seq_K562_Human0.96667326
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95734640
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95435376
117CJUN_26792858_Chip-Seq_BT549_Human0.95274260
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95160208
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95011598
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94834658
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94161404
122* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94056836
123GATA1_19941826_ChIP-Seq_K562_Human0.93614224
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93569455
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.93352231
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91203804
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90980977
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90451055
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89539262
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88909167
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.88737966
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87538841
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87342049
134* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87247491
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87104921
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86746711
137PU_27001747_Chip-Seq_BMDM_Mouse0.86595360
138AHR_22903824_ChIP-Seq_MCF-7_Human0.86468560
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86258562
140ZNF274_21170338_ChIP-Seq_K562_Hela0.85936452
141EGR1_19374776_ChIP-ChIP_THP-1_Human0.85619200
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85253873
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84852078
144SPI1_23127762_ChIP-Seq_K562_Human0.83351588
145TP63_23658742_ChIP-Seq_EP156T_Human0.82052291
146BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82046420
147TP53_16413492_ChIP-PET_HCT116_Human0.80653569
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80129122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.66084712
2MP0002837_dystrophic_cardiac_calcinosis5.64538514
3MP0004084_abnormal_cardiac_muscle5.03343054
4MP0000751_myopathy4.78586436
5MP0004215_abnormal_myocardial_fiber3.97872432
6MP0004036_abnormal_muscle_relaxation3.88951391
7MP0000749_muscle_degeneration3.50800911
8* MP0005330_cardiomyopathy3.30518613
9MP0004130_abnormal_muscle_cell3.08554136
10* MP0004087_abnormal_muscle_fiber3.06107981
11MP0002972_abnormal_cardiac_muscle2.83745713
12MP0000750_abnormal_muscle_regeneration2.73896207
13MP0005620_abnormal_muscle_contractility2.66294052
14MP0008775_abnormal_heart_ventricle2.66280541
15MP0002106_abnormal_muscle_physiology2.53954456
16MP0004145_abnormal_muscle_electrophysio2.51494177
17* MP0005385_cardiovascular_system_phenoty2.43019776
18* MP0001544_abnormal_cardiovascular_syste2.43019776
19MP0000747_muscle_weakness2.41982280
20* MP0004484_altered_response_of2.40457310
21* MP0010630_abnormal_cardiac_muscle2.39742629
22MP0006138_congestive_heart_failure2.37229036
23MP0003137_abnormal_impulse_conducting2.28901908
24MP0002269_muscular_atrophy2.22265260
25MP0003724_increased_susceptibility_to2.20983545
26MP0005409_darkened_coat_color2.17746832
27MP0000759_abnormal_skeletal_muscle2.13883727
28MP0005666_abnormal_adipose_tissue2.12290946
29MP0005369_muscle_phenotype2.10193679
30MP0003221_abnormal_cardiomyocyte_apopto2.03833092
31MP0004185_abnormal_adipocyte_glucose1.98500428
32MP0003828_pulmonary_edema1.97959796
33MP0003705_abnormal_hypodermis_morpholog1.96925802
34MP0004233_abnormal_muscle_weight1.82737229
35MP0004085_abnormal_heartbeat1.80019885
36MP0003191_abnormal_cellular_cholesterol1.71703826
37MP0003300_gastrointestinal_ulcer1.65104170
38MP0005375_adipose_tissue_phenotype1.57784480
39MP0003303_peritoneal_inflammation1.54308724
40MP0004510_myositis1.49616580
41MP0003690_abnormal_glial_cell1.48636391
42MP0006036_abnormal_mitochondrial_physio1.48101131
43MP0003567_abnormal_fetal_cardiomyocyte1.46769070
44MP0002009_preneoplasia1.43512191
45MP0003950_abnormal_plasma_membrane1.42300225
46MP0005670_abnormal_white_adipose1.39369167
47MP0005623_abnormal_meninges_morphology1.37267632
48MP0001661_extended_life_span1.33827052
49MP0002127_abnormal_cardiovascular_syste1.31931291
50MP0003091_abnormal_cell_migration1.31042969
51MP0008260_abnormal_autophagy1.29832762
52MP0002332_abnormal_exercise_endurance1.28708247
53MP0005085_abnormal_gallbladder_physiolo1.27869600
54MP0008438_abnormal_cutaneous_collagen1.26741732
55MP0002234_abnormal_pharynx_morphology1.25964264
56MP0000003_abnormal_adipose_tissue1.16600465
57MP0003252_abnormal_bile_duct1.15889257
58MP0000013_abnormal_adipose_tissue1.14149655
59MP0002132_abnormal_respiratory_system1.12364944
60MP0000733_abnormal_muscle_development1.10895753
61MP0005076_abnormal_cell_differentiation1.09331634
62MP0005083_abnormal_biliary_tract1.07794517
63* MP0000266_abnormal_heart_morphology1.07623456
64MP0004272_abnormal_basement_membrane1.06909049
65MP0003183_abnormal_peptide_metabolism1.06337839
66MP0000569_abnormal_digit_pigmentation1.05868963
67MP0000920_abnormal_myelination1.05765467
68MP0002108_abnormal_muscle_morphology1.05341045
69MP0003868_abnormal_feces_composition1.02194034
70MP0005275_abnormal_skin_tensile1.01300574
71MP0002971_abnormal_brown_adipose0.99787924
72MP0002139_abnormal_hepatobiliary_system0.97594082
73MP0002909_abnormal_adrenal_gland0.97078124
74MP0004270_analgesia0.96172328
75MP0005248_abnormal_Harderian_gland0.95941105
76MP0000343_altered_response_to0.95047098
77MP0003566_abnormal_cell_adhesion0.92168223
78MP0010368_abnormal_lymphatic_system0.91785797
79MP0009780_abnormal_chondrocyte_physiolo0.91020097
80MP0005165_increased_susceptibility_to0.89214356
81MP0004043_abnormal_pH_regulation0.88818433
82MP0004883_abnormal_blood_vessel0.87494887
83MP0001915_intracranial_hemorrhage0.84194078
84MP0001958_emphysema0.79877730
85MP0004381_abnormal_hair_follicle0.78721676
86MP0002138_abnormal_hepatobiliary_system0.77999908
87MP0008874_decreased_physiological_sensi0.77411320
88MP0005166_decreased_susceptibility_to0.76714756
89MP0005164_abnormal_response_to0.75780082
90MP0008961_abnormal_basal_metabolism0.75119357
91* MP0002128_abnormal_blood_circulation0.74434710
92MP0009840_abnormal_foam_cell0.71568423
93MP0003279_aneurysm0.71565890
94MP0000230_abnormal_systemic_arterial0.70434742
95MP0002166_altered_tumor_susceptibility0.68408043
96MP0001851_eye_inflammation0.68103247
97MP0003656_abnormal_erythrocyte_physiolo0.67936817
98MP0001879_abnormal_lymphatic_vessel0.67687752
99MP0010678_abnormal_skin_adnexa0.67015897
100MP0005187_abnormal_penis_morphology0.66228046
101MP0003634_abnormal_glial_cell0.65695883
102MP0006035_abnormal_mitochondrial_morpho0.64926099
103MP0005058_abnormal_lysosome_morphology0.64538602
104MP0003879_abnormal_hair_cell0.63248231
105MP0002877_abnormal_melanocyte_morpholog0.62322801
106MP0009384_cardiac_valve_regurgitation0.59000341
107MP0003632_abnormal_nervous_system0.58464967
108MP0002998_abnormal_bone_remodeling0.57607063
109MP0005365_abnormal_bile_salt0.56993759
110MP0000465_gastrointestinal_hemorrhage0.56895981
111MP0005451_abnormal_body_composition0.56502615
112MP0002419_abnormal_innate_immunity0.56048043
113MP0002078_abnormal_glucose_homeostasis0.55986851
114* MP0002925_abnormal_cardiovascular_devel0.54294781
115MP0003045_fibrosis0.50677257
116MP0005266_abnormal_metabolism0.49779491
117MP0005334_abnormal_fat_pad0.48997467
118MP0004858_abnormal_nervous_system0.47690864
119MP0000767_abnormal_smooth_muscle0.47480388
120MP0005535_abnormal_body_temperature0.44574398
121MP0003195_calcinosis0.44564034
122MP0001784_abnormal_fluid_regulation0.44500646
123* MP0001614_abnormal_blood_vessel0.43369082
124MP0002088_abnormal_embryonic_growth/wei0.43117581
125MP0003984_embryonic_growth_retardation0.42845618
126MP0002118_abnormal_lipid_homeostasis0.42684008
127MP0002295_abnormal_pulmonary_circulatio0.42403920
128MP0003329_amyloid_beta_deposits0.40048991
129MP0005167_abnormal_blood-brain_barrier0.37532466
130MP0009115_abnormal_fat_cell0.37506120
131MP0010234_abnormal_vibrissa_follicle0.36971289
132MP0003948_abnormal_gas_homeostasis0.36809320
133MP0002970_abnormal_white_adipose0.36690432
134MP0002896_abnormal_bone_mineralization0.36098016
135MP0005595_abnormal_vascular_smooth0.35861587
136MP0010352_gastrointestinal_tract_polyps0.35555904
137MP0001299_abnormal_eye_distance/0.35207918
138MP0001727_abnormal_embryo_implantation0.34763352
139MP0008569_lethality_at_weaning0.34283014
140MP0005332_abnormal_amino_acid0.34121307
141MP0002090_abnormal_vision0.32797239

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.70386572
2Exercise-induced muscle cramps (HP:0003710)6.45029927
3Exercise-induced myalgia (HP:0003738)5.90603694
4Calf muscle hypertrophy (HP:0008981)5.72821658
5Ventricular tachycardia (HP:0004756)5.54696579
6Muscle hypertrophy of the lower extremities (HP:0008968)5.45233247
7Muscle fiber splitting (HP:0003555)5.40963993
8Myoglobinuria (HP:0002913)5.35201021
9Hyporeflexia of lower limbs (HP:0002600)4.83304087
10Atrial fibrillation (HP:0005110)4.81020492
11Abnormality of the calf musculature (HP:0001430)4.63273916
12Primary atrial arrhythmia (HP:0001692)4.50982523
13Bundle branch block (HP:0011710)4.36701142
14Supraventricular tachycardia (HP:0004755)4.30710821
15Lipoatrophy (HP:0100578)4.27350669
16Right ventricular cardiomyopathy (HP:0011663)4.24564979
17Supraventricular arrhythmia (HP:0005115)4.24389945
18Difficulty running (HP:0009046)4.23528925
19Abnormality of the left ventricular outflow tract (HP:0011103)4.23297374
20Subaortic stenosis (HP:0001682)4.23297374
21Rhabdomyolysis (HP:0003201)4.09151127
22Increased connective tissue (HP:0009025)3.91950489
23EMG: myopathic abnormalities (HP:0003458)3.91281896
24Syncope (HP:0001279)3.89911399
25Asymmetric septal hypertrophy (HP:0001670)3.65371666
26Dilated cardiomyopathy (HP:0001644)3.56772034
27Palpitations (HP:0001962)3.52061820
28Distal arthrogryposis (HP:0005684)3.49283376
29Prolonged QT interval (HP:0001657)3.49220597
30Heart block (HP:0012722)3.41600552
31Ventricular arrhythmia (HP:0004308)3.41127221
32Atrioventricular block (HP:0001678)3.36214038
33Ventricular fibrillation (HP:0001663)3.31876600
34Muscle fiber inclusion bodies (HP:0100299)3.31045037
35Abnormal atrioventricular conduction (HP:0005150)3.25571999
36Myotonia (HP:0002486)3.23253394
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.21977782
38Centrally nucleated skeletal muscle fibers (HP:0003687)3.20577717
39Difficulty climbing stairs (HP:0003551)3.18076396
40Type 1 muscle fiber predominance (HP:0003803)3.16452975
41Muscle stiffness (HP:0003552)3.00279650
42Increased variability in muscle fiber diameter (HP:0003557)2.95786798
43Conjunctival hamartoma (HP:0100780)2.76105984
44Abnormality of skeletal muscle fiber size (HP:0012084)2.72289440
45Hypoglycemic coma (HP:0001325)2.69972958
46Ketoacidosis (HP:0001993)2.68981256
47Ulnar deviation of the wrist (HP:0003049)2.66931140
48Nemaline bodies (HP:0003798)2.61001265
49Arterial tortuosity (HP:0005116)2.50799786
50Eczematoid dermatitis (HP:0000976)2.47951700
51Dysmetric saccades (HP:0000641)2.47085077
52Abnormal EKG (HP:0003115)2.45162641
53Calcaneovalgus deformity (HP:0001848)2.40846164
54Neck muscle weakness (HP:0000467)2.38750723
55Bulbar palsy (HP:0001283)2.37115053
56Hamartoma of the eye (HP:0010568)2.32939936
57Broad metatarsal (HP:0001783)2.32639351
58Abnormality of fatty-acid metabolism (HP:0004359)2.29885800
59Pheochromocytoma (HP:0002666)2.29865245
60Vascular tortuosity (HP:0004948)2.29637384
61Limb-girdle muscle atrophy (HP:0003797)2.25503694
62Cerebral aneurysm (HP:0004944)2.20169534
63Round ear (HP:0100830)2.20154536
64Deep venous thrombosis (HP:0002625)2.19772616
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18351535
66Dicarboxylic aciduria (HP:0003215)2.18351535
67Areflexia of lower limbs (HP:0002522)2.18295374
68Left ventricular hypertrophy (HP:0001712)2.16359839
69Palmoplantar keratoderma (HP:0000982)2.12781657
70Hepatic necrosis (HP:0002605)2.11112976
71Athetosis (HP:0002305)2.10010789
72Peritonitis (HP:0002586)2.09668802
73Scapular winging (HP:0003691)2.07754857
74Myopathic facies (HP:0002058)2.04932793
75Protrusio acetabuli (HP:0003179)2.04311122
76Hypoplastic ischia (HP:0003175)2.03091293
77Distal lower limb muscle weakness (HP:0009053)2.01931711
78Deformed tarsal bones (HP:0008119)1.99612241
79Rimmed vacuoles (HP:0003805)1.98872843
80Mildly elevated creatine phosphokinase (HP:0008180)1.98126354
81Spontaneous hematomas (HP:0007420)1.96964052
82Absent phalangeal crease (HP:0006109)1.96258817
83Sudden cardiac death (HP:0001645)1.93873668
84Lymphangioma (HP:0100764)1.93066838
85Increased muscle lipid content (HP:0009058)1.92927808
86Ketosis (HP:0001946)1.90765382
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90354402
88Distal lower limb amyotrophy (HP:0008944)1.89598564
89Neuroendocrine neoplasm (HP:0100634)1.89508446
90Testicular atrophy (HP:0000029)1.88817103
91Recurrent gram-negative bacterial infections (HP:0005420)1.88180864
92Abnormality of the foot musculature (HP:0001436)1.86955120
93Hyperglycemia (HP:0003074)1.86533802
94Amyloidosis (HP:0011034)1.86129847
95Muscular dystrophy (HP:0003560)1.85083779
96Abnormal mitochondria in muscle tissue (HP:0008316)1.84852042
97Papillary thyroid carcinoma (HP:0002895)1.84728929
98Insulin-resistant diabetes mellitus (HP:0000831)1.83768962
99Aortic aneurysm (HP:0004942)1.83660230
100Foot dorsiflexor weakness (HP:0009027)1.83618520
101Congestive heart failure (HP:0001635)1.82438688
102Proximal amyotrophy (HP:0007126)1.81529482
103Vertebral arch anomaly (HP:0008438)1.81320980
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80826418
105Abnormality of alanine metabolism (HP:0010916)1.80826418
106Hyperalaninemia (HP:0003348)1.80826418
107EMG: neuropathic changes (HP:0003445)1.78390426
108Large for gestational age (HP:0001520)1.78374929
109Gowers sign (HP:0003391)1.77766166
110Facial diplegia (HP:0001349)1.77406293
111Rapidly progressive (HP:0003678)1.76029866
112Frequent falls (HP:0002359)1.74216625
113Acute necrotizing encephalopathy (HP:0006965)1.73627124
114Subacute progressive viral hepatitis (HP:0006572)1.73465487
115Limb-girdle muscle weakness (HP:0003325)1.73250387
116Generalized muscle weakness (HP:0003324)1.73051748
117Cholecystitis (HP:0001082)1.72128890
118Abnormal gallbladder physiology (HP:0012438)1.72128890
119Hyperkalemia (HP:0002153)1.71602292
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71519772
121Abnormality of the ischium (HP:0003174)1.71261884
122Mitral stenosis (HP:0001718)1.71058779
123Hyperglycinuria (HP:0003108)1.70292215
124Hypoalphalipoproteinemia (HP:0003233)1.69816950
125Neoplasm of the adrenal gland (HP:0100631)1.69199473
126Spinal rigidity (HP:0003306)1.67796407
127Abnormality of the calcaneus (HP:0008364)1.67581987
128Abnormality of the endocardium (HP:0004306)1.67180722
129Orchitis (HP:0100796)1.66344063
130Hypoplasia of the iris (HP:0007676)1.65797872
131Hypercortisolism (HP:0001578)1.63541811
132Myositis (HP:0100614)1.63220338
133Increased IgE level (HP:0003212)1.62536147
134Lower limb amyotrophy (HP:0007210)1.62472455
135Gastrointestinal infarctions (HP:0005244)1.60731105
136Cerebral inclusion bodies (HP:0100314)1.60544682
137Abnormal finger flexion creases (HP:0006143)1.60143839
138Increased CSF protein (HP:0002922)1.58855826
139Fetal akinesia sequence (HP:0001989)1.56011695
140Malignant hyperthermia (HP:0002047)1.54990570
141Neurofibrillary tangles (HP:0002185)1.54400738
142Cubitus valgus (HP:0002967)1.52794237
143Onion bulb formation (HP:0003383)1.51119484
144Testicular neoplasm (HP:0010788)1.50244953
145Mitral valve prolapse (HP:0001634)1.49449595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.53624358
2TRIB34.53329516
3PKN24.25495180
4OBSCN3.63190368
5PHKG23.44855879
6PHKG13.44855879
7PDK33.12092927
8PDK43.12092927
9DMPK2.91648129
10LMTK22.76830101
11NEK12.34262500
12MAP3K62.27376039
13PRPF4B2.02339221
14MYLK1.90127168
15MAP3K21.79958164
16BCKDK1.79806725
17PIK3CG1.74778114
18PDK21.72894617
19STK241.68448948
20MAP3K131.61929300
21MAPK71.54740127
22PIK3CA1.51691858
23MOS1.51391773
24ERN11.47210467
25PINK11.47042333
26PDGFRA1.37677801
27RIPK11.36228532
28FGFR31.35118828
29ILK1.33302348
30YES11.31641699
31TGFBR21.25675870
32LATS11.25611926
33PAK31.23814570
34PRKD11.22907345
35TAOK31.21448225
36SGK21.18480604
37ZAP701.18479980
38CSK1.15271408
39NEK91.11265034
40WNK41.08020598
41PRKD31.02259721
42PTK61.02095381
43TYK21.02002589
44TIE11.00367554
45MAP2K60.99669841
46MAP3K70.98545939
47BLK0.97390471
48PBK0.95810593
49TAOK10.95410409
50EPHB10.95214283
51RET0.95052848
52SCYL20.94658384
53KSR20.94180993
54IRAK40.93198937
55MARK10.89084796
56LRRK20.88983932
57EEF2K0.87651721
58MAPK120.87490484
59SGK4940.86262410
60SGK2230.86262410
61RIPK40.84751455
62MAP2K30.84673642
63CAMK2D0.84145490
64SIK10.83436835
65LATS20.83112840
66STK380.82340079
67MARK20.80964003
68PRKAA10.80942958
69NTRK10.80037535
70RAF10.79847833
71JAK20.77855561
72MAP3K50.77095293
73PDPK10.77061666
74ICK0.76356579
75ROCK10.76187266
76FLT30.74474735
77PAK60.73915260
78PRKAA20.70378812
79WNK10.69236317
80FGFR40.68984673
81EPHB20.67926000
82RPS6KB10.66043629
83TRPM70.65306187
84MUSK0.64431022
85MAP2K10.63204936
86PRKCH0.62657064
87STK38L0.62134475
88PDK10.62098953
89ROCK20.62043845
90CAMK1G0.61836602
91STK390.61296802
92DYRK1B0.60466453
93CAMK1D0.57938020
94CAMK40.57477092
95AKT30.55037303
96SGK30.54819582
97CDC42BPA0.54786835
98NTRK30.53499592
99MAP3K30.52613672
100HCK0.52057713
101IRAK20.51853726
102CDK60.51589670
103CAMKK10.51068846
104GRK70.51037081
105TAOK20.50985213
106MST1R0.50957251
107MAP3K100.50688792
108MAP2K40.49786048
109MAPK110.49421252
110FES0.49360925
111PDGFRB0.49278470
112ALK0.49274329
113PKN10.48061945
114FGFR10.47823498
115FER0.47771007
116CDK120.47240668
117MAP3K90.46078809
118STK110.46028596
119CAMK10.45244103
120MTOR0.44994782
121DAPK30.44021822
122PRKG20.43422937
123TBK10.43141169
124BMX0.40242230
125MET0.39699962
126ARAF0.39186675
127CAMK2A0.39042907
128STK40.38916796
129EPHA30.37919551
130BMPR20.37263073
131MAP3K10.35000750
132NME10.33950766
133FGFR20.33846535
134AKT20.33842932
135KSR10.32115430
136CAMK2G0.31008923
137RPS6KC10.30892821
138RPS6KL10.30892821
139MAP3K40.30840041
140PRKACB0.30477071
141PRKACG0.30347627
142PTK2B0.29553995
143RPS6KA10.28382778
144SGK10.27908680
145JAK10.27341949
146PRKCE0.27272266
147PTK20.26222672

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.28598493
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83325709
3Dilated cardiomyopathy_Homo sapiens_hsa054143.17107405
4Cardiac muscle contraction_Homo sapiens_hsa042603.16295027
5Propanoate metabolism_Homo sapiens_hsa006403.13380036
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.02072372
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.67426280
8Fatty acid degradation_Homo sapiens_hsa000712.66186056
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54540342
10Carbon metabolism_Homo sapiens_hsa012002.34824767
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29855081
12Fatty acid metabolism_Homo sapiens_hsa012122.24295791
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21811300
14Parkinsons disease_Homo sapiens_hsa050121.92737524
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71049449
16Oxidative phosphorylation_Homo sapiens_hsa001901.67909890
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61742932
18Pyruvate metabolism_Homo sapiens_hsa006201.53947245
19Alzheimers disease_Homo sapiens_hsa050101.53687524
20Butanoate metabolism_Homo sapiens_hsa006501.51667068
21Viral myocarditis_Homo sapiens_hsa054161.46929694
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42967433
23Insulin resistance_Homo sapiens_hsa049311.34366860
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29725246
25PPAR signaling pathway_Homo sapiens_hsa033201.28811255
26Insulin signaling pathway_Homo sapiens_hsa049101.21383108
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.19998143
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.18913400
29Pancreatic cancer_Homo sapiens_hsa052121.18786579
30Glucagon signaling pathway_Homo sapiens_hsa049221.18065995
31Osteoclast differentiation_Homo sapiens_hsa043801.12899543
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12470169
33AMPK signaling pathway_Homo sapiens_hsa041521.11956616
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09831393
35Biosynthesis of amino acids_Homo sapiens_hsa012301.09007001
36Huntingtons disease_Homo sapiens_hsa050161.07733928
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07111123
38Focal adhesion_Homo sapiens_hsa045101.05653310
39ErbB signaling pathway_Homo sapiens_hsa040121.05636454
40Fatty acid elongation_Homo sapiens_hsa000621.04807731
41Nitrogen metabolism_Homo sapiens_hsa009101.03184307
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03019377
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.02138328
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99269880
45B cell receptor signaling pathway_Homo sapiens_hsa046620.98901783
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98770509
47Complement and coagulation cascades_Homo sapiens_hsa046100.98633218
48Choline metabolism in cancer_Homo sapiens_hsa052310.97935717
49Arginine biosynthesis_Homo sapiens_hsa002200.97723160
50Starch and sucrose metabolism_Homo sapiens_hsa005000.92879070
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91965654
52Acute myeloid leukemia_Homo sapiens_hsa052210.91118699
53Oxytocin signaling pathway_Homo sapiens_hsa049210.90462951
54Type II diabetes mellitus_Homo sapiens_hsa049300.88665885
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87374260
56Prion diseases_Homo sapiens_hsa050200.85207180
57Tight junction_Homo sapiens_hsa045300.85179675
58mTOR signaling pathway_Homo sapiens_hsa041500.84686224
59Prolactin signaling pathway_Homo sapiens_hsa049170.84322565
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83954396
61Leishmaniasis_Homo sapiens_hsa051400.82469953
62Fatty acid biosynthesis_Homo sapiens_hsa000610.82467185
63* HIF-1 signaling pathway_Homo sapiens_hsa040660.82024618
64Long-term depression_Homo sapiens_hsa047300.81726510
65Pancreatic secretion_Homo sapiens_hsa049720.80541096
66Pentose phosphate pathway_Homo sapiens_hsa000300.79864727
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77631180
68Lysine degradation_Homo sapiens_hsa003100.77414834
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75798885
70Gastric acid secretion_Homo sapiens_hsa049710.75476050
71Inositol phosphate metabolism_Homo sapiens_hsa005620.75030390
72* Renal cell carcinoma_Homo sapiens_hsa052110.73554278
73Staphylococcus aureus infection_Homo sapiens_hsa051500.73424235
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73198447
75beta-Alanine metabolism_Homo sapiens_hsa004100.71080421
76Tuberculosis_Homo sapiens_hsa051520.68111649
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67915037
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67745279
79Renin secretion_Homo sapiens_hsa049240.67737756
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.67639608
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.66805867
82Calcium signaling pathway_Homo sapiens_hsa040200.66188085
83Proteoglycans in cancer_Homo sapiens_hsa052050.65402490
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63691560
85Adherens junction_Homo sapiens_hsa045200.62072191
86ECM-receptor interaction_Homo sapiens_hsa045120.61881885
87Dorso-ventral axis formation_Homo sapiens_hsa043200.60654937
88Galactose metabolism_Homo sapiens_hsa000520.60533173
89T cell receptor signaling pathway_Homo sapiens_hsa046600.59536592
90Chemokine signaling pathway_Homo sapiens_hsa040620.59520998
91VEGF signaling pathway_Homo sapiens_hsa043700.59351447
92Thyroid cancer_Homo sapiens_hsa052160.59054605
93Arginine and proline metabolism_Homo sapiens_hsa003300.55746534
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55732178
95Amoebiasis_Homo sapiens_hsa051460.54523926
96cAMP signaling pathway_Homo sapiens_hsa040240.53577187
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51221462
98Phenylalanine metabolism_Homo sapiens_hsa003600.50909972
99Tryptophan metabolism_Homo sapiens_hsa003800.49924691
100Rap1 signaling pathway_Homo sapiens_hsa040150.49625727
101Prostate cancer_Homo sapiens_hsa052150.49437074
102Toxoplasmosis_Homo sapiens_hsa051450.49426391
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49026412
104GnRH signaling pathway_Homo sapiens_hsa049120.48385241
105TNF signaling pathway_Homo sapiens_hsa046680.48122928
106Endocytosis_Homo sapiens_hsa041440.48055647
107Circadian rhythm_Homo sapiens_hsa047100.47355806
108Glioma_Homo sapiens_hsa052140.46522221
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46345048
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45925199
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43880862
112Fructose and mannose metabolism_Homo sapiens_hsa000510.43619150
113Insulin secretion_Homo sapiens_hsa049110.43088529
114Estrogen signaling pathway_Homo sapiens_hsa049150.42550530
115Gap junction_Homo sapiens_hsa045400.41738675
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40471845
117Endometrial cancer_Homo sapiens_hsa052130.40210431
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40139766
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39803315
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39486020
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.38928058
122Long-term potentiation_Homo sapiens_hsa047200.38866980
123Circadian entrainment_Homo sapiens_hsa047130.38480456
124FoxO signaling pathway_Homo sapiens_hsa040680.37833318
125Cholinergic synapse_Homo sapiens_hsa047250.37450228
126Melanogenesis_Homo sapiens_hsa049160.34670725
127Non-small cell lung cancer_Homo sapiens_hsa052230.31451175
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.30449487
129Small cell lung cancer_Homo sapiens_hsa052220.29635106
130Platelet activation_Homo sapiens_hsa046110.29005133
131Salivary secretion_Homo sapiens_hsa049700.27639222
132Hippo signaling pathway_Homo sapiens_hsa043900.27359846
133Glycerolipid metabolism_Homo sapiens_hsa005610.26512358
134Bile secretion_Homo sapiens_hsa049760.26383948
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25811757
136Chronic myeloid leukemia_Homo sapiens_hsa052200.25201523
137Peroxisome_Homo sapiens_hsa041460.24291202
138MAPK signaling pathway_Homo sapiens_hsa040100.23953361

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