EGLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.91857180
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.84510066
3lateral sprouting from an epithelium (GO:0060601)5.43340272
4sarcomere organization (GO:0045214)5.11954701
5desmosome organization (GO:0002934)5.02600399
6establishment of skin barrier (GO:0061436)4.97700191
7otic vesicle formation (GO:0030916)4.81967837
8* 4-hydroxyproline metabolic process (GO:0019471)4.62504455
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.60005452
10glomerular basement membrane development (GO:0032836)4.59867265
11negative regulation of protein localization to cell surface (GO:2000009)4.46943478
12keratinocyte proliferation (GO:0043616)4.37100960
13regulation of water loss via skin (GO:0033561)4.27870459
14actin-myosin filament sliding (GO:0033275)4.07364685
15muscle filament sliding (GO:0030049)4.07364685
16cell-substrate junction assembly (GO:0007044)4.03690980
17regulation of skeletal muscle contraction (GO:0014819)3.81765201
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.74013437
19limb bud formation (GO:0060174)3.70652362
20multicellular organismal water homeostasis (GO:0050891)3.67709090
21hair cycle (GO:0042633)3.65312825
22molting cycle (GO:0042303)3.65312825
23apoptotic process involved in morphogenesis (GO:0060561)3.54456429
24plasma membrane repair (GO:0001778)3.52272186
25pentose-phosphate shunt (GO:0006098)3.52011892
26ventricular cardiac muscle cell action potential (GO:0086005)3.41856072
27embryonic camera-type eye development (GO:0031076)3.41083455
28cardiac myofibril assembly (GO:0055003)3.40512244
29positive regulation of histone deacetylation (GO:0031065)3.37427499
30actin-mediated cell contraction (GO:0070252)3.32955200
31muscle cell fate commitment (GO:0042693)3.32268151
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29095456
33mesonephros development (GO:0001823)3.24882092
34gap junction assembly (GO:0016264)3.24787485
35regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.23641385
36tricarboxylic acid cycle (GO:0006099)3.22588557
37epithelial cell-cell adhesion (GO:0090136)3.22560441
38epidermal cell differentiation (GO:0009913)3.17826287
39peptide cross-linking (GO:0018149)3.17640760
40regulation of keratinocyte proliferation (GO:0010837)3.16328585
41glomerular filtration (GO:0003094)3.15777951
42interferon-gamma secretion (GO:0072643)3.13929672
43mesenchymal-epithelial cell signaling (GO:0060638)3.12879684
44NADPH regeneration (GO:0006740)3.12049845
45striated muscle hypertrophy (GO:0014897)3.11453049
46intermediate filament organization (GO:0045109)3.11276019
47lung epithelium development (GO:0060428)3.09859680
48peripheral nervous system axon ensheathment (GO:0032292)3.09602420
49myelination in peripheral nervous system (GO:0022011)3.09602420
50growth hormone receptor signaling pathway (GO:0060396)3.08894626
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08528622
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08528622
53positive regulation of focal adhesion assembly (GO:0051894)3.07988994
54positive regulation of cell junction assembly (GO:1901890)3.07988994
55water homeostasis (GO:0030104)3.05795226
56regulation of protein localization to cell surface (GO:2000008)3.05278719
57regulation of bile acid biosynthetic process (GO:0070857)3.04382522
58myofibril assembly (GO:0030239)3.03501863
59actomyosin structure organization (GO:0031032)3.02769518
60bicarbonate transport (GO:0015701)3.02449283
61glycolytic process (GO:0006096)2.96278374
622-oxoglutarate metabolic process (GO:0006103)2.94818635
63long-chain fatty acid biosynthetic process (GO:0042759)2.94304057
64cardiac muscle cell action potential involved in contraction (GO:0086002)2.93295065
65epidermis development (GO:0008544)2.93151808
66cardiac muscle contraction (GO:0060048)2.90551417
67cardiac muscle cell action potential (GO:0086001)2.90236718
68heart trabecula formation (GO:0060347)2.89148254
69actin filament-based movement (GO:0030048)2.88337938
70organ formation (GO:0048645)2.86767266
71positive regulation of glomerulus development (GO:0090193)2.86588039
72mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.85753147
73cardiac muscle cell development (GO:0055013)2.85374205
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83876768
75renal filtration (GO:0097205)2.83803936
76glucose 6-phosphate metabolic process (GO:0051156)2.83643220
77regulation of glomerulus development (GO:0090192)2.82941672
78chemical homeostasis within a tissue (GO:0048875)2.82254521
79positive regulation of digestive system process (GO:0060456)2.82139600
80prostaglandin biosynthetic process (GO:0001516)2.81178144
81prostanoid biosynthetic process (GO:0046457)2.81178144
82keratinization (GO:0031424)2.80315463
83phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.79546422
84positive regulation of adherens junction organization (GO:1903393)2.78725638
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78540805
86carnitine shuttle (GO:0006853)2.77714326
87oxaloacetate metabolic process (GO:0006107)2.77264243
88glucose catabolic process (GO:0006007)2.76852107
89phosphatidylserine acyl-chain remodeling (GO:0036150)2.76336875
90cardiac cell development (GO:0055006)2.76319312
91skeletal muscle adaptation (GO:0043501)2.75866426
92surfactant homeostasis (GO:0043129)2.75650683
93response to muscle activity (GO:0014850)2.75506404
94skin morphogenesis (GO:0043589)2.75301382
95radial glial cell differentiation (GO:0060019)2.74393219
96regulation of cardiac muscle cell contraction (GO:0086004)2.73922606
97T cell apoptotic process (GO:0070231)2.73816295
98regulation of heart rate by cardiac conduction (GO:0086091)2.73057017
99hepatocyte apoptotic process (GO:0097284)2.72691221
100sodium ion export (GO:0071436)2.70070434
101negative regulation of heart growth (GO:0061117)2.69596289
102negative regulation of cardiac muscle tissue growth (GO:0055022)2.69596289
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.69533003
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68071282
105cell communication by electrical coupling (GO:0010644)2.67495700
106regulation of cholesterol homeostasis (GO:2000188)2.67017948
107regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66436602
108defense response to fungus (GO:0050832)2.64794767
109cardiac conduction (GO:0061337)2.64764181
110fructose metabolic process (GO:0006000)2.64218788
111cranial suture morphogenesis (GO:0060363)2.63901149
112creatine metabolic process (GO:0006600)2.63865166
113lung vasculature development (GO:0060426)2.63404558
114tricarboxylic acid metabolic process (GO:0072350)2.63253488
115positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.63244578
116maternal placenta development (GO:0001893)2.62815047
117decidualization (GO:0046697)2.62763434
118kidney morphogenesis (GO:0060993)2.62355841
119organ induction (GO:0001759)2.61127038
120regulation of cardioblast differentiation (GO:0051890)2.60433290
121phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60030936
122focal adhesion assembly (GO:0048041)2.59581545
123cell-substrate adherens junction assembly (GO:0007045)2.59581545
124trophectodermal cell differentiation (GO:0001829)2.58598832
125regulation of actin filament-based movement (GO:1903115)2.57701558
126negative regulation of keratinocyte proliferation (GO:0010839)2.57699586
127striated muscle atrophy (GO:0014891)2.56614376
128regulation of p38MAPK cascade (GO:1900744)2.56553288
129cardiac muscle tissue morphogenesis (GO:0055008)2.56134970
130striated muscle contraction (GO:0006941)2.55299508
131muscle hypertrophy (GO:0014896)2.54486643
132valine metabolic process (GO:0006573)2.54300518
133gas transport (GO:0015669)2.52855928
134protein localization to cell surface (GO:0034394)2.51596104
135pyruvate metabolic process (GO:0006090)2.51250546
136cellular response to growth hormone stimulus (GO:0071378)2.51179203
137cell communication involved in cardiac conduction (GO:0086065)2.50948674
138type B pancreatic cell proliferation (GO:0044342)2.49245052
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48267476
140tyrosine phosphorylation of STAT protein (GO:0007260)2.48253961
141cardiac epithelial to mesenchymal transition (GO:0060317)2.48091623
142fatty acid transmembrane transport (GO:1902001)2.47032875
143regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.46703898
144ventricular cardiac muscle cell development (GO:0055015)2.45489257
145regulation of transforming growth factor beta2 production (GO:0032909)2.45468136
146negative regulation of cell size (GO:0045792)2.45173872
147low-density lipoprotein particle clearance (GO:0034383)2.44127934
148regulation of cofactor metabolic process (GO:0051193)2.43809558
149regulation of coenzyme metabolic process (GO:0051196)2.43809558
150* protein hydroxylation (GO:0018126)2.43678123
151positive regulation of p38MAPK cascade (GO:1900745)2.43390035
152brown fat cell differentiation (GO:0050873)2.43054971
153regulation of sequestering of triglyceride (GO:0010889)2.42688861
154hypotonic response (GO:0006971)2.42440092
155branching involved in salivary gland morphogenesis (GO:0060445)2.41877150
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40744952
157mesodermal cell differentiation (GO:0048333)2.40295737
158positive regulation of vascular permeability (GO:0043117)2.39959812
159muscle tissue morphogenesis (GO:0060415)2.39603996
160negative regulation of fatty acid transport (GO:2000192)2.39418732
161lymphocyte apoptotic process (GO:0070227)2.38789555
162atrioventricular valve morphogenesis (GO:0003181)2.37224182
163positive regulation of protein deacetylation (GO:0090312)2.37020512
164negative regulation of T cell differentiation in thymus (GO:0033085)2.36811717
165epithelial structure maintenance (GO:0010669)2.36463308
166ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.36344044
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36286622
168regulation of translational fidelity (GO:0006450)2.35267859
169adherens junction assembly (GO:0034333)2.35252874
170positive regulation of triglyceride biosynthetic process (GO:0010867)2.32947321
171keratinocyte differentiation (GO:0030216)2.30664952
172apoptotic process involved in development (GO:1902742)2.30582595
173lysine metabolic process (GO:0006553)2.30305373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.53412648
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96512594
3ZNF263_19887448_ChIP-Seq_K562_Human3.86777268
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44237549
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96195867
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60868519
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.59344875
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56210516
9* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51345308
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.35460398
11CLOCK_20551151_ChIP-Seq_293T_Human2.32759234
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.21347136
13MYC_22102868_ChIP-Seq_BL_Human2.16245900
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.14323664
15* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12189898
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.10930645
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.04145056
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01641550
19* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97266044
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.94588107
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.94465447
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91264416
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91147930
24E2F7_22180533_ChIP-Seq_HELA_Human1.88376221
25ATF3_27146783_Chip-Seq_COLON_Human1.85060174
26RACK7_27058665_Chip-Seq_MCF-7_Human1.84760237
27VDR_21846776_ChIP-Seq_THP-1_Human1.83292064
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.82941451
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82748397
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78919837
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.75414758
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74270919
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.69734054
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.67996252
35* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66034049
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.64858282
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61121814
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59925029
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58597776
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57411622
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57147862
42* KDM2B_26808549_Chip-Seq_DND41_Human1.55971603
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.54849460
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.54849460
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.54288656
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.54288656
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.54288656
48GATA6_25053715_ChIP-Seq_YYC3_Human1.51133011
49MAF_26560356_Chip-Seq_TH1_Human1.50505732
50* PIAS1_25552417_ChIP-Seq_VCAP_Human1.50259040
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.49918694
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46920617
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45653765
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44587176
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43987559
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42969921
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.42419255
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41425848
59AR_21909140_ChIP-Seq_LNCAP_Human1.41223322
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41087178
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40838533
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.40032288
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39115174
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38902080
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38406480
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38336738
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38336738
68* LXR_22292898_ChIP-Seq_THP-1_Human1.37660536
69* LXR_22158963_ChIP-Seq_LIVER_Mouse1.37530625
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.36132353
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36127942
72VDR_22108803_ChIP-Seq_LS180_Human1.35512313
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35154483
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.34356782
75* CJUN_26792858_Chip-Seq_BT549_Human1.32286182
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32227253
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30038540
78* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29555326
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27826042
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27701164
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25821198
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25358783
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24883244
84AHR_22903824_ChIP-Seq_MCF-7_Human1.23183182
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21734995
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21358075
87TP53_18474530_ChIP-ChIP_U2OS_Human1.20439586
88VDR_24763502_ChIP-Seq_THP-1_Human1.20388174
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19795769
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19286519
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19040007
92EGR1_19032775_ChIP-ChIP_M12_Human1.18816930
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16189194
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15413450
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15336608
96* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15192665
97UTX_26944678_Chip-Seq_JUKART_Human1.14417811
98TP63_23658742_ChIP-Seq_EP156T_Human1.13788357
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.13781285
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13600046
101* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13236580
102* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13236580
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12978886
104TP53_16413492_ChIP-PET_HCT116_Human1.12271288
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.11732848
106PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10448048
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10059571
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09474058
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09165741
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08388742
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.07455060
112CDX2_20551321_ChIP-Seq_CACO-2_Human1.07395569
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07204828
114* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06816781
115NCOR1_26117541_ChIP-Seq_K562_Human1.06632402
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06354722
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06346438
118* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04915938
119GATA4_25053715_ChIP-Seq_YYC3_Human1.04611696
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04397071
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04091658
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02578943
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98906063
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98698024
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98603829
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98479468
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97582928
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.96769975
129MYB_26560356_Chip-Seq_TH2_Human0.96557098
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.95372390
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94122580
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93692931
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92244840
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92121103
135* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91952110
136CDX2_22108803_ChIP-Seq_LS180_Human0.91129497
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90682451
138CREB1_26743006_Chip-Seq_LNCaP_Human0.89998736
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89804414
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89654374
141* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89337003
142CHD1_26751641_Chip-Seq_LNCaP_Human0.88964323
143* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88961220
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88783736
145* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88760765
146TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88075164
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.87196286
148TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86729542
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86450042
150* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86154586
151SOX2_20726797_ChIP-Seq_SW620_Human0.86026859
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85859200
153* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85335930
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85217948
155* KLF5_25053715_ChIP-Seq_YYC3_Human0.85140566
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84915867
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82929605
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82174874
159* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82151145
160SMAD4_21799915_ChIP-Seq_A2780_Human0.82031332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.84429435
2MP0003878_abnormal_ear_physiology4.84429435
3MP0010234_abnormal_vibrissa_follicle4.45733574
4MP0004084_abnormal_cardiac_muscle3.75906840
5MP0003705_abnormal_hypodermis_morpholog3.31836916
6MP0005257_abnormal_intraocular_pressure3.04573042
7MP0003941_abnormal_skin_development2.65956763
8MP0002837_dystrophic_cardiac_calcinosis2.61639013
9MP0010352_gastrointestinal_tract_polyps2.50660714
10MP0000750_abnormal_muscle_regeneration2.49353827
11MP0000751_myopathy2.40176841
12MP0003566_abnormal_cell_adhesion2.35951826
13MP0000566_synostosis2.33665139
14MP0004036_abnormal_muscle_relaxation2.28021129
15MP0005330_cardiomyopathy2.22616118
16MP0003646_muscle_fatigue2.13146250
17MP0004885_abnormal_endolymph2.11479662
18MP0003300_gastrointestinal_ulcer2.11266593
19MP0010030_abnormal_orbit_morphology2.11086137
20MP0001849_ear_inflammation2.07131595
21MP0004087_abnormal_muscle_fiber2.05088216
22MP0002796_impaired_skin_barrier1.99911776
23MP0002102_abnormal_ear_morphology1.96961317
24MP0010630_abnormal_cardiac_muscle1.90770450
25MP0004185_abnormal_adipocyte_glucose1.87555437
26MP0005248_abnormal_Harderian_gland1.77807859
27MP0003453_abnormal_keratinocyte_physiol1.68997753
28MP0002254_reproductive_system_inflammat1.68884695
29MP0000749_muscle_degeneration1.67778550
30MP0005076_abnormal_cell_differentiation1.67475377
31MP0002972_abnormal_cardiac_muscle1.66087809
32MP0004130_abnormal_muscle_cell1.64923326
33MP0002106_abnormal_muscle_physiology1.64004531
34MP0005360_urolithiasis1.63105384
35MP0004215_abnormal_myocardial_fiber1.59161917
36MP0005385_cardiovascular_system_phenoty1.55368121
37MP0001544_abnormal_cardiovascular_syste1.55368121
38MP0008775_abnormal_heart_ventricle1.53357468
39MP0005666_abnormal_adipose_tissue1.53255385
40MP0003221_abnormal_cardiomyocyte_apopto1.49272155
41MP0002234_abnormal_pharynx_morphology1.49057917
42MP0005501_abnormal_skin_physiology1.45601901
43MP0001485_abnormal_pinna_reflex1.45230410
44MP0005409_darkened_coat_color1.40331740
45MP0003567_abnormal_fetal_cardiomyocyte1.38845589
46MP0002269_muscular_atrophy1.38482687
47MP0002060_abnormal_skin_morphology1.37924095
48MP0005275_abnormal_skin_tensile1.37294255
49MP0005023_abnormal_wound_healing1.35371527
50MP0004782_abnormal_surfactant_physiolog1.34929473
51MP0004264_abnormal_extraembryonic_tissu1.34548747
52MP0005620_abnormal_muscle_contractility1.33486197
53MP0004272_abnormal_basement_membrane1.32183455
54MP0000733_abnormal_muscle_development1.31289236
55MP0003828_pulmonary_edema1.30406052
56MP0004484_altered_response_of1.30215853
57MP0003866_abnormal_defecation1.28665844
58MP0010678_abnormal_skin_adnexa1.28347986
59MP0003806_abnormal_nucleotide_metabolis1.28325814
60MP0001216_abnormal_epidermal_layer1.26182538
61MP0009840_abnormal_foam_cell1.24335324
62MP0003303_peritoneal_inflammation1.23046371
63MP0004947_skin_inflammation1.22921860
64MP0000759_abnormal_skeletal_muscle1.21994451
65MP0004085_abnormal_heartbeat1.21215729
66MP0005369_muscle_phenotype1.18232322
67MP0010155_abnormal_intestine_physiology1.18227107
68MP0005375_adipose_tissue_phenotype1.17658261
69MP0000747_muscle_weakness1.17440415
70MP0008004_abnormal_stomach_pH1.16717468
71MP0002877_abnormal_melanocyte_morpholog1.16539109
72MP0000858_altered_metastatic_potential1.15816556
73MP0000678_abnormal_parathyroid_gland1.13726402
74MP0009379_abnormal_foot_pigmentation1.12745954
75MP0003937_abnormal_limbs/digits/tail_de1.11967570
76MP0006138_congestive_heart_failure1.10388236
77MP0001881_abnormal_mammary_gland1.08184237
78MP0003119_abnormal_digestive_system1.06625625
79MP0003436_decreased_susceptibility_to1.06265854
80MP0000647_abnormal_sebaceous_gland1.04715025
81MP0001879_abnormal_lymphatic_vessel1.02153834
82MP0000467_abnormal_esophagus_morphology1.01055853
83MP0001756_abnormal_urination0.98043105
84MP0004510_myositis0.95752789
85MP0003938_abnormal_ear_development0.95092290
86MP0003045_fibrosis0.94644980
87MP0003137_abnormal_impulse_conducting0.94114428
88MP0000537_abnormal_urethra_morphology0.93041598
89MP0000579_abnormal_nail_morphology0.92026422
90MP0000762_abnormal_tongue_morphology0.91816220
91MP0000343_altered_response_to0.90352152
92MP0002132_abnormal_respiratory_system0.90023228
93MP0004043_abnormal_pH_regulation0.89846978
94MP0000627_abnormal_mammary_gland0.89758286
95MP0001502_abnormal_circadian_rhythm0.89431888
96MP0000377_abnormal_hair_follicle0.88453384
97MP0005165_increased_susceptibility_to0.86357829
98MP0004270_analgesia0.85355066
99MP0009053_abnormal_anal_canal0.84765290
100MP0001853_heart_inflammation0.84494528
101MP0000266_abnormal_heart_morphology0.84056255
102MP0002127_abnormal_cardiovascular_syste0.83957289
103MP0002933_joint_inflammation0.83153356
104MP0002166_altered_tumor_susceptibility0.83033411
105MP0009931_abnormal_skin_appearance0.82388775
106MP0005085_abnormal_gallbladder_physiolo0.80808178
107MP0000383_abnormal_hair_follicle0.80340567
108MP0000026_abnormal_inner_ear0.80262799
109MP0000477_abnormal_intestine_morphology0.79717903
110MP0002282_abnormal_trachea_morphology0.79486147
111MP0002088_abnormal_embryonic_growth/wei0.78204091
112MP0000003_abnormal_adipose_tissue0.78187331
113MP0002098_abnormal_vibrissa_morphology0.77629222
114MP0003984_embryonic_growth_retardation0.77610499
115MP0002697_abnormal_eye_size0.76816416
116MP0003763_abnormal_thymus_physiology0.76361467
117MP0001666_abnormal_nutrient_absorption0.76237925
118MP0005365_abnormal_bile_salt0.75794511
119MP0002396_abnormal_hematopoietic_system0.74863624
120MP0000490_abnormal_crypts_of0.74105094
121MP0002249_abnormal_larynx_morphology0.73960992
122MP0004197_abnormal_fetal_growth/weight/0.73601388
123MP0002111_abnormal_tail_morphology0.72447878
124MP0010329_abnormal_lipoprotein_level0.71919506
125MP0002925_abnormal_cardiovascular_devel0.70775136
126MP0010771_integument_phenotype0.70674645
127MP0003448_altered_tumor_morphology0.70574530
128MP0005319_abnormal_enzyme/_coenzyme0.70422392
129MP0002233_abnormal_nose_morphology0.69553929
130MP0005670_abnormal_white_adipose0.69495884
131* MP0000230_abnormal_systemic_arterial0.69175842
132MP0002971_abnormal_brown_adipose0.69105805
133MP0003950_abnormal_plasma_membrane0.68764317
134MP0000609_abnormal_liver_physiology0.68327715
135MP0004019_abnormal_vitamin_homeostasis0.68140099
136MP0002295_abnormal_pulmonary_circulatio0.68115508
137MP0010307_abnormal_tumor_latency0.66763324
138MP0002086_abnormal_extraembryonic_tissu0.65883145
139MP0001188_hyperpigmentation0.64829048
140MP0005332_abnormal_amino_acid0.64539278
141MP0009780_abnormal_chondrocyte_physiolo0.64088634
142MP0000534_abnormal_ureter_morphology0.63689621
143MP0003942_abnormal_urinary_system0.60274146
144MP0008438_abnormal_cutaneous_collagen0.59848023
145MP0004742_abnormal_vestibular_system0.56851909
146MP0010368_abnormal_lymphatic_system0.56230848
147MP0003890_abnormal_embryonic-extraembry0.54295995
148MP0003718_maternal_effect0.53279871
149MP0002108_abnormal_muscle_morphology0.52857890
150MP0003136_yellow_coat_color0.52615370
151MP0001784_abnormal_fluid_regulation0.50447279
152MP0003115_abnormal_respiratory_system0.49421230

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.48172411
2Exercise-induced muscle cramps (HP:0003710)5.47107420
3Abnormality of nail color (HP:0100643)5.23024485
4Ventricular tachycardia (HP:0004756)4.93419554
5Sudden death (HP:0001699)4.39103017
6Myoglobinuria (HP:0002913)4.38509776
7Milia (HP:0001056)4.31749083
8Aplasia involving bones of the extremities (HP:0009825)4.12028241
9Aplasia involving bones of the upper limbs (HP:0009823)4.12028241
10Aplasia of the phalanges of the hand (HP:0009802)4.12028241
11Hyporeflexia of lower limbs (HP:0002600)4.11414964
12Corneal erosion (HP:0200020)3.89439478
13Rhabdomyolysis (HP:0003201)3.84518366
14Onycholysis (HP:0001806)3.84393368
15Increased connective tissue (HP:0009025)3.81770554
16Popliteal pterygium (HP:0009756)3.76896671
17Abnormality of the salivary glands (HP:0010286)3.73350258
18Muscle fiber splitting (HP:0003555)3.70390299
19Palmoplantar hyperkeratosis (HP:0000972)3.68709877
20Palmar hyperkeratosis (HP:0010765)3.54515216
21Exercise-induced myalgia (HP:0003738)3.54255839
22Abnormal auditory evoked potentials (HP:0006958)3.52133939
23Fragile nails (HP:0001808)3.48684661
24Atrophic scars (HP:0001075)3.43339608
25Type 1 muscle fiber predominance (HP:0003803)3.38672154
26Muscle fiber inclusion bodies (HP:0100299)3.30117123
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.24805386
28Partial duplication of thumb phalanx (HP:0009944)3.24797747
29Erythroderma (HP:0001019)3.18031190
30Congenital ichthyosiform erythroderma (HP:0007431)3.16982510
31Thick nail (HP:0001805)3.06534230
32Ependymoma (HP:0002888)3.04216015
33Calf muscle hypertrophy (HP:0008981)2.96788423
34Lipoatrophy (HP:0100578)2.93614134
35Abnormality of the left ventricular outflow tract (HP:0011103)2.91996543
36Subaortic stenosis (HP:0001682)2.91996543
37Recurrent corneal erosions (HP:0000495)2.90435455
38Oral leukoplakia (HP:0002745)2.88086762
39EMG: myopathic abnormalities (HP:0003458)2.87405386
40Hyperactive renin-angiotensin system (HP:0000841)2.84640827
41Difficulty running (HP:0009046)2.82559032
42Nemaline bodies (HP:0003798)2.82329829
43Glomerulonephritis (HP:0000099)2.79943222
44Hypotrichosis (HP:0001006)2.76386587
45Pili torti (HP:0003777)2.75697636
46Plantar hyperkeratosis (HP:0007556)2.74769310
47Axonal loss (HP:0003447)2.71073613
48Muscle hypertrophy of the lower extremities (HP:0008968)2.68158118
49Partial duplication of the phalanx of hand (HP:0009999)2.67800452
50Erythema (HP:0010783)2.65169583
51Palpitations (HP:0001962)2.64523137
52Alacrima (HP:0000522)2.62873623
53Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.60223542
54Abnormality of the calf musculature (HP:0001430)2.59906345
55Decreased lacrimation (HP:0000633)2.58206693
56Difficulty climbing stairs (HP:0003551)2.53649091
57Abnormality of placental membranes (HP:0011409)2.50489916
58Amniotic constriction ring (HP:0009775)2.50489916
59Atrial fibrillation (HP:0005110)2.49794562
60Corneal dystrophy (HP:0001131)2.48084601
61Ulnar deviation of the wrist (HP:0003049)2.47044079
62Limb-girdle muscle atrophy (HP:0003797)2.43641165
63Dilated cardiomyopathy (HP:0001644)2.42735247
64Abnormality of glycolysis (HP:0004366)2.41764397
65Primary atrial arrhythmia (HP:0001692)2.38478429
66Aplasia of the musculature (HP:0100854)2.34838167
67Myopathic facies (HP:0002058)2.34061065
68Ventricular arrhythmia (HP:0004308)2.34039940
69Muscle stiffness (HP:0003552)2.32850107
70Abnormality of the dental root (HP:0006486)2.32403671
71Taurodontia (HP:0000679)2.32403671
72Abnormality of permanent molar morphology (HP:0011071)2.32403671
73Supraventricular tachycardia (HP:0004755)2.31746586
74Mildly elevated creatine phosphokinase (HP:0008180)2.31204317
75Supraventricular arrhythmia (HP:0005115)2.30307066
76Distal lower limb muscle weakness (HP:0009053)2.29144133
77Syncope (HP:0001279)2.27290971
78Abnormality of secondary sexual hair (HP:0009888)2.26334567
79Abnormality of the axillary hair (HP:0100134)2.26334567
80Hypoplastic pelvis (HP:0008839)2.21166826
81Astrocytoma (HP:0009592)2.20361106
82Abnormality of the astrocytes (HP:0100707)2.20361106
83Abnormal blistering of the skin (HP:0008066)2.19803783
84Abnormality of skeletal muscle fiber size (HP:0012084)2.17347308
85Polar cataract (HP:0010696)2.17200115
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17013261
87Woolly hair (HP:0002224)2.15921788
88Nail dystrophy (HP:0008404)2.15820454
89Hypoplasia of the iris (HP:0007676)2.13861926
90Asymmetric septal hypertrophy (HP:0001670)2.13712211
91Split foot (HP:0001839)2.11330949
92Rectal prolapse (HP:0002035)2.10318991
93Bundle branch block (HP:0011710)2.10318690
94Abnormality of molar morphology (HP:0011070)2.08702896
95Abnormality of molar (HP:0011077)2.08702896
96Round ear (HP:0100830)2.08521983
97Conjunctival hamartoma (HP:0100780)2.08108258
98Distal arthrogryposis (HP:0005684)2.07980925
99Frequent falls (HP:0002359)2.07096954
100Palmoplantar keratoderma (HP:0000982)2.04143411
101Distal lower limb amyotrophy (HP:0008944)2.03136523
102Nephritis (HP:0000123)2.02528653
103Dysmetric saccades (HP:0000641)2.02306794
104Abnormality of the dental pulp (HP:0006479)2.01911200
105Segmental peripheral demyelination/remyelination (HP:0003481)2.01116430
106Pterygium (HP:0001059)2.01046304
107Pustule (HP:0200039)2.00525571
108Hyperkalemia (HP:0002153)2.00468407
109Atrioventricular block (HP:0001678)1.99623242
110Increased variability in muscle fiber diameter (HP:0003557)1.99295660
111Confusion (HP:0001289)1.98670451
112Broad metatarsal (HP:0001783)1.97394994
113Mixed hearing impairment (HP:0000410)1.96818377
114Neck muscle weakness (HP:0000467)1.96277016
115Increased IgE level (HP:0003212)1.96014299
116Paralysis (HP:0003470)1.94909095
117Increased density of long bones (HP:0006392)1.93808534
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93493415
119Lip pit (HP:0100267)1.91779798
120Nasolacrimal duct obstruction (HP:0000579)1.91153376
121Aplasia cutis congenita (HP:0001057)1.90832311
122Myotonia (HP:0002486)1.90265095
123Areflexia of lower limbs (HP:0002522)1.89917739
124Biliary tract neoplasm (HP:0100574)1.89746725
125Flat acetabular roof (HP:0003180)1.89008757
126Abnormal hair laboratory examination (HP:0003328)1.87571848
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87234148
128Abnormality of the labia majora (HP:0012881)1.86792029
129Follicular hyperkeratosis (HP:0007502)1.86518486
130Abnormal atrioventricular conduction (HP:0005150)1.86478080
131Ureteral stenosis (HP:0000071)1.86245746
132Abnormality of incisor morphology (HP:0011063)1.85882816
133Esophageal varix (HP:0002040)1.84490408
134Parakeratosis (HP:0001036)1.84478127
135Heart block (HP:0012722)1.83627008
136Shallow orbits (HP:0000586)1.83399971
137Aneurysm (HP:0002617)1.83222480
138Skin pits (HP:0100276)1.82865426
139Conical tooth (HP:0000698)1.82706405
140Scapular winging (HP:0003691)1.82362349
141Hypoplastic labia majora (HP:0000059)1.81357168
142Abnormality of sodium homeostasis (HP:0010931)1.80984341
143Achilles tendon contracture (HP:0001771)1.79312040
144Abnormality of proline metabolism (HP:0010907)1.78403543
145Hydroxyprolinuria (HP:0003080)1.78403543
146Fused cervical vertebrae (HP:0002949)1.78402064
147Cholecystitis (HP:0001082)1.76361789
148Abnormal gallbladder physiology (HP:0012438)1.76361789
149Ankle contracture (HP:0006466)1.74131579
150Fragile skin (HP:0001030)1.72759146
151Abnormality of the Achilles tendon (HP:0005109)1.71876045
152Cerebral aneurysm (HP:0004944)1.71844749
153Ventricular fibrillation (HP:0001663)1.71803681
154Abnormality of the neuromuscular junction (HP:0003398)1.71722056
155Acanthocytosis (HP:0001927)1.71445569
156Intrahepatic cholestasis (HP:0001406)1.70994923
157Ectropion (HP:0000656)1.70667031
158Increased serum pyruvate (HP:0003542)1.70300484
159Abnormality of the lacrimal duct (HP:0011481)1.70041862
160Alopecia of scalp (HP:0002293)1.69575708
161Abnormality of the gastric mucosa (HP:0004295)1.69251895
162Sudden cardiac death (HP:0001645)1.68529992
163Slender build (HP:0001533)1.67843476
164Reticulocytosis (HP:0001923)1.67749865
165Curly hair (HP:0002212)1.65156490
166Spinal rigidity (HP:0003306)1.64523147
167Ureteral obstruction (HP:0006000)1.63789212
168Facial diplegia (HP:0001349)1.62542181
169Interstitial pulmonary disease (HP:0006530)1.61742374
170Fatigable weakness (HP:0003473)1.60647149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN25.21682106
2EPHA24.29472343
3TRIB33.86933015
4EEF2K3.49456508
5TTN3.47851156
6PBK3.21615676
7STK392.68101321
8EPHB12.33575318
9RIPK12.25422285
10MATK2.18731383
11FLT32.06887288
12TNIK1.93620905
13SIK11.85069571
14PTK61.84463630
15NEK11.80164854
16EPHA41.77915370
17LATS21.66610604
18OBSCN1.65777644
19ERN11.62887677
20ACVR1B1.62867510
21DMPK1.60382456
22FGFR41.59575266
23STK101.58626391
24MET1.58328659
25LRRK21.57685471
26LMTK21.54181713
27BCR1.51593980
28RPS6KB21.50171381
29PIK3CA1.45358853
30MAP2K31.45203963
31NTRK11.43226025
32MOS1.42405298
33STK38L1.40977207
34EPHA31.39883392
35MUSK1.37300578
36MAP3K101.33055229
37NME21.31811161
38WEE11.30572170
39TRIM281.30145673
40PDK41.27433324
41PDK31.27433324
42MAP3K71.24977924
43BMX1.24119218
44BRSK21.22841475
45MAP3K31.19875149
46FER1.15481487
47MAP3K91.13870674
48ROCK21.12860525
49MAPKAPK51.12689255
50MAP4K11.11947776
51SGK2231.11277346
52SGK4941.11277346
53MAPKAPK31.10673588
54EIF2AK31.10562282
55MST41.08366065
56MST1R1.08067745
57FGFR11.07814392
58MAP3K61.07643352
59TRPM71.06285832
60WNK41.02368007
61EIF2AK11.01548238
62OXSR11.01227067
63PAK40.96779011
64JAK30.94475120
65STK240.94082508
66INSRR0.93633477
67CAMK2B0.93380297
68BCKDK0.92189764
69PHKG20.91315659
70PHKG10.91315659
71PTK20.90161569
72LATS10.89956624
73CAMK2D0.89751623
74CDK60.89547292
75ARAF0.89541147
76CASK0.89516929
77TTK0.86819071
78FGFR30.85380929
79MAP3K80.84472164
80EPHB20.84327000
81ILK0.84019897
82TAOK10.83939335
83TIE10.82787938
84PDGFRA0.82192765
85NEK60.80669729
86TYK20.80436672
87NME10.80025985
88MKNK10.79892697
89ALK0.79643680
90RET0.78935941
91GRK60.78506691
92MAP3K110.77093581
93CDK120.74262259
94ZAP700.73340871
95ROCK10.71333297
96MYLK0.68368767
97CDK40.67351270
98RPS6KA40.67194881
99PRKCE0.65932476
100ERBB20.65790803
101FRK0.62223287
102PIM20.61568584
103ITK0.61200020
104MKNK20.60852989
105TGFBR10.60644407
106NLK0.60178148
107PLK20.58001599
108BMPR1B0.56928373
109MAP2K20.56783958
110PAK20.56654767
111MAP3K120.56397820
112JAK20.56230331
113MTOR0.55586336
114NEK90.54871301
115ERBB30.54028079
116MAP3K10.52946470
117PIM10.52530502
118NTRK20.51790502
119TBK10.50896581
120MAP3K50.50133981
121MAPK110.49520828
122KSR20.48541230
123PAK30.48293109
124CAMK2A0.46950025
125PRKD10.46176919
126CAMK2G0.45566735
127PLK40.45449298
128SCYL20.45419582
129GRK50.45031125
130PDGFRB0.45021418
131JAK10.44912043
132AKT20.43829286
133HCK0.43080684
134PRKAA20.42202770
135STK40.42019127
136RPS6KA10.40544678
137PIK3CG0.40148092
138BTK0.39759311
139MAPKAPK20.39674169
140MAP3K20.39489617
141PINK10.39315277
142PDK20.39313638
143STK30.38360561
144MAP2K10.37159654
145DAPK30.36855078
146EGFR0.36770434
147TESK10.36463234
148NEK20.36221824
149IGF1R0.36156149
150PKN10.35528351
151GRK10.33864792
152TSSK60.31244787
153MAPK150.30167006
154SRPK10.29679996
155PRKG20.29111475

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.21572417
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.97955018
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.62954922
4Carbon metabolism_Homo sapiens_hsa012002.45325199
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43551350
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.42965276
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30188053
8Central carbon metabolism in cancer_Homo sapiens_hsa052302.23987778
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23163523
10Fatty acid degradation_Homo sapiens_hsa000712.14713766
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13488726
12Biosynthesis of amino acids_Homo sapiens_hsa012302.08972888
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08839235
14Histidine metabolism_Homo sapiens_hsa003402.00207709
15Dilated cardiomyopathy_Homo sapiens_hsa054141.91563742
16Bladder cancer_Homo sapiens_hsa052191.83831022
17Linoleic acid metabolism_Homo sapiens_hsa005911.83452956
18Protein digestion and absorption_Homo sapiens_hsa049741.79438767
19Circadian rhythm_Homo sapiens_hsa047101.76864849
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73300774
21Small cell lung cancer_Homo sapiens_hsa052221.70254400
22* HIF-1 signaling pathway_Homo sapiens_hsa040661.68346413
23Viral myocarditis_Homo sapiens_hsa054161.65981323
24Propanoate metabolism_Homo sapiens_hsa006401.61073636
25Galactose metabolism_Homo sapiens_hsa000521.60979913
26Arachidonic acid metabolism_Homo sapiens_hsa005901.57848589
27Adherens junction_Homo sapiens_hsa045201.57446422
28Starch and sucrose metabolism_Homo sapiens_hsa005001.52764955
29Pentose phosphate pathway_Homo sapiens_hsa000301.52115231
30Arginine biosynthesis_Homo sapiens_hsa002201.51687798
31ECM-receptor interaction_Homo sapiens_hsa045121.49751487
32Fat digestion and absorption_Homo sapiens_hsa049751.46620614
33Fatty acid metabolism_Homo sapiens_hsa012121.40976572
34Focal adhesion_Homo sapiens_hsa045101.39929656
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39303706
36Toxoplasmosis_Homo sapiens_hsa051451.38601467
37Pyruvate metabolism_Homo sapiens_hsa006201.36081788
38Insulin resistance_Homo sapiens_hsa049311.33468239
39PPAR signaling pathway_Homo sapiens_hsa033201.28929685
40Amoebiasis_Homo sapiens_hsa051461.26732138
41Ether lipid metabolism_Homo sapiens_hsa005651.26708193
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25524604
43Chronic myeloid leukemia_Homo sapiens_hsa052201.25073736
44Fructose and mannose metabolism_Homo sapiens_hsa000511.24450563
45Mineral absorption_Homo sapiens_hsa049781.23928158
46Proteoglycans in cancer_Homo sapiens_hsa052051.20716016
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.18742077
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16709433
49Renin-angiotensin system_Homo sapiens_hsa046141.14372286
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12105347
51Acute myeloid leukemia_Homo sapiens_hsa052211.10946913
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09247710
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.08347218
54Vitamin digestion and absorption_Homo sapiens_hsa049771.06948098
55Pancreatic secretion_Homo sapiens_hsa049721.06301466
56Thyroid cancer_Homo sapiens_hsa052161.05773231
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05012285
58Phenylalanine metabolism_Homo sapiens_hsa003601.02056829
59Retinol metabolism_Homo sapiens_hsa008301.01041088
60Fatty acid elongation_Homo sapiens_hsa000621.00893763
61Lysine degradation_Homo sapiens_hsa003100.98991353
62Steroid biosynthesis_Homo sapiens_hsa001000.96448628
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93309658
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92219169
65Insulin signaling pathway_Homo sapiens_hsa049100.91304161
66Caffeine metabolism_Homo sapiens_hsa002320.91222960
67Pancreatic cancer_Homo sapiens_hsa052120.90638858
68Fatty acid biosynthesis_Homo sapiens_hsa000610.89834177
69Tight junction_Homo sapiens_hsa045300.89596258
70beta-Alanine metabolism_Homo sapiens_hsa004100.87838705
71Non-small cell lung cancer_Homo sapiens_hsa052230.87827257
72Glucagon signaling pathway_Homo sapiens_hsa049220.86530496
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.85755979
74Nitrogen metabolism_Homo sapiens_hsa009100.84066064
75MicroRNAs in cancer_Homo sapiens_hsa052060.84030931
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80797553
77Leishmaniasis_Homo sapiens_hsa051400.80412141
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.78818341
79Endometrial cancer_Homo sapiens_hsa052130.77765253
80Hippo signaling pathway_Homo sapiens_hsa043900.75121560
81AMPK signaling pathway_Homo sapiens_hsa041520.74003279
82Cardiac muscle contraction_Homo sapiens_hsa042600.73057296
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72539808
84Thyroid hormone synthesis_Homo sapiens_hsa049180.71520139
85Hedgehog signaling pathway_Homo sapiens_hsa043400.70769826
86mTOR signaling pathway_Homo sapiens_hsa041500.70469444
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69905982
88Sphingolipid metabolism_Homo sapiens_hsa006000.69860805
89VEGF signaling pathway_Homo sapiens_hsa043700.69789883
90Chemical carcinogenesis_Homo sapiens_hsa052040.69206691
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69105933
92Renin secretion_Homo sapiens_hsa049240.68795257
93Bile secretion_Homo sapiens_hsa049760.68271626
94Sulfur metabolism_Homo sapiens_hsa009200.66125312
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.64360173
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64254477
97Legionellosis_Homo sapiens_hsa051340.64123220
98Basal cell carcinoma_Homo sapiens_hsa052170.60574537
99Tryptophan metabolism_Homo sapiens_hsa003800.58123459
100Arginine and proline metabolism_Homo sapiens_hsa003300.56179152
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55720044
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.55400789
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54471487
104Serotonergic synapse_Homo sapiens_hsa047260.53569548
105Gap junction_Homo sapiens_hsa045400.52838326
106Osteoclast differentiation_Homo sapiens_hsa043800.51952780
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51145458
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49767991
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48970195
110p53 signaling pathway_Homo sapiens_hsa041150.48815863
111Hematopoietic cell lineage_Homo sapiens_hsa046400.48758679
112Ovarian steroidogenesis_Homo sapiens_hsa049130.48127143
113TGF-beta signaling pathway_Homo sapiens_hsa043500.48069562
114HTLV-I infection_Homo sapiens_hsa051660.47245648
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46324049
116Platelet activation_Homo sapiens_hsa046110.45766966
117TNF signaling pathway_Homo sapiens_hsa046680.44949690
118Measles_Homo sapiens_hsa051620.44760904
119Glycerolipid metabolism_Homo sapiens_hsa005610.44554873
120One carbon pool by folate_Homo sapiens_hsa006700.44444642
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.44431119
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44190102
123* Pathways in cancer_Homo sapiens_hsa052000.44049524
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43421464
125Viral carcinogenesis_Homo sapiens_hsa052030.42722793
126T cell receptor signaling pathway_Homo sapiens_hsa046600.42292749
127Glutathione metabolism_Homo sapiens_hsa004800.42246824
128Apoptosis_Homo sapiens_hsa042100.41552517
129Gastric acid secretion_Homo sapiens_hsa049710.40611904
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39752914
131Salivary secretion_Homo sapiens_hsa049700.38817663
132Notch signaling pathway_Homo sapiens_hsa043300.38657257
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38060127
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.37874420
135Prostate cancer_Homo sapiens_hsa052150.37625905
136* Renal cell carcinoma_Homo sapiens_hsa052110.37408345
137Salmonella infection_Homo sapiens_hsa051320.36555188
138Selenocompound metabolism_Homo sapiens_hsa004500.35246255
139Rap1 signaling pathway_Homo sapiens_hsa040150.35210414
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34591066
141Prolactin signaling pathway_Homo sapiens_hsa049170.34141402
142Tyrosine metabolism_Homo sapiens_hsa003500.34088126
143Butanoate metabolism_Homo sapiens_hsa006500.33465456
144Metabolic pathways_Homo sapiens_hsa011000.32876735
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32459788
146Hepatitis C_Homo sapiens_hsa051600.31643040
147Melanogenesis_Homo sapiens_hsa049160.30936971
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30303517
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30290044
150Shigellosis_Homo sapiens_hsa051310.30183764
151FoxO signaling pathway_Homo sapiens_hsa040680.29866330
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29511609
153Long-term depression_Homo sapiens_hsa047300.28887227
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28430794
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26480698
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.26445597

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