EGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)5.55825082
2positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.28212936
3regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.28212936
4positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.24890524
5regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.24890524
6lymph vessel development (GO:0001945)3.95959777
7presynaptic membrane assembly (GO:0097105)3.74197616
8facial nerve structural organization (GO:0021612)3.73718314
9epithelial cell fate commitment (GO:0072148)3.71681818
10auditory receptor cell differentiation (GO:0042491)3.69936288
11cell migration involved in sprouting angiogenesis (GO:0002042)3.68793382
12presynaptic membrane organization (GO:0097090)3.44453796
13positive regulation of mRNA catabolic process (GO:0061014)3.42070544
14lactate metabolic process (GO:0006089)3.41937985
15nonmotile primary cilium assembly (GO:0035058)3.40369219
16cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.31232045
17dendritic spine morphogenesis (GO:0060997)3.29807654
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.29543470
19lung lobe morphogenesis (GO:0060463)3.24918888
20response to gravity (GO:0009629)3.23203689
21dentate gyrus development (GO:0021542)3.18009679
22photoreceptor cell differentiation (GO:0046530)3.17971412
23eye photoreceptor cell differentiation (GO:0001754)3.17971412
24microglial cell activation (GO:0001774)3.17264191
25endocrine pancreas development (GO:0031018)3.13673814
26SMAD protein signal transduction (GO:0060395)3.08475000
27response to progesterone (GO:0032570)3.08424733
28regulation of type B pancreatic cell apoptotic process (GO:2000674)3.07494426
29response to corticosterone (GO:0051412)3.05140952
30fibroblast migration (GO:0010761)3.03865512
31regulation of mRNA catabolic process (GO:0061013)3.01393095
32neuron fate determination (GO:0048664)3.00538617
33negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98142672
34startle response (GO:0001964)2.96460526
35astrocyte differentiation (GO:0048708)2.95639264
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94388474
37positive regulation of calcium ion import (GO:0090280)2.94016708
38positive regulation of glycolytic process (GO:0045821)2.90936686
39blood vessel maturation (GO:0001955)2.89302776
40G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.89068601
41ER overload response (GO:0006983)2.88224822
42RNA destabilization (GO:0050779)2.87038144
43ovulation from ovarian follicle (GO:0001542)2.84773680
44* cellular response to gonadotropin stimulus (GO:0071371)2.84582317
45regulation of neurotransmitter uptake (GO:0051580)2.83395513
46negative regulation of complement activation (GO:0045916)2.82172253
47negative regulation of cAMP-mediated signaling (GO:0043951)2.81292110
48nodal signaling pathway (GO:0038092)2.80300512
49cranial nerve structural organization (GO:0021604)2.79120649
50chondroitin sulfate catabolic process (GO:0030207)2.77621956
51regulation of male gonad development (GO:2000018)2.77597131
52negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75350245
53negative regulation of translation, ncRNA-mediated (GO:0040033)2.75350245
54regulation of translation, ncRNA-mediated (GO:0045974)2.75350245
55response to mineralocorticoid (GO:0051385)2.73964384
56inner ear receptor stereocilium organization (GO:0060122)2.73546767
57blood vessel endothelial cell migration (GO:0043534)2.72465868
58regulation of p38MAPK cascade (GO:1900744)2.71919361
59endocardial cushion morphogenesis (GO:0003203)2.71385513
60righting reflex (GO:0060013)2.70469670
61negative regulation of protein autophosphorylation (GO:0031953)2.69794454
62negative regulation of systemic arterial blood pressure (GO:0003085)2.69405040
63positive regulation of mRNA 3-end processing (GO:0031442)2.69114616
64* skeletal muscle cell differentiation (GO:0035914)2.67797390
65nephron tubule formation (GO:0072079)2.66487602
66white fat cell differentiation (GO:0050872)2.64760537
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64227829
68gland morphogenesis (GO:0022612)2.62587229
69glomerulus development (GO:0032835)2.62065242
70cellular ketone body metabolic process (GO:0046950)2.61313206
71positive regulation of glycogen biosynthetic process (GO:0045725)2.61015787
72atrioventricular valve morphogenesis (GO:0003181)2.60753473
73negative regulation of hormone biosynthetic process (GO:0032353)2.59118679
74positive regulation of p38MAPK cascade (GO:1900745)2.58811006
75brain morphogenesis (GO:0048854)2.58128364
76positive regulation of astrocyte differentiation (GO:0048711)2.56279826
77prostate gland growth (GO:0060736)2.55626762
78mesenchyme morphogenesis (GO:0072132)2.54591473
79positive regulation of insulin secretion (GO:0032024)2.54302043
80lung vasculature development (GO:0060426)2.54257761
81axoneme assembly (GO:0035082)2.53318067
82insulin secretion (GO:0030073)2.51712499
83embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51529745
84parental behavior (GO:0060746)2.51055008
85cell differentiation involved in metanephros development (GO:0072202)2.50471216
86negative regulation of myoblast differentiation (GO:0045662)2.47344521
87renal tubule morphogenesis (GO:0061333)2.47165958
88smooth muscle tissue development (GO:0048745)2.46523581
89otic vesicle formation (GO:0030916)2.46300240
90pharyngeal system development (GO:0060037)2.45263711
91branching involved in labyrinthine layer morphogenesis (GO:0060670)2.44936319
92negative regulation of gluconeogenesis (GO:0045721)2.44255274
93metanephric nephron tubule development (GO:0072234)2.43491434
94metanephric tubule development (GO:0072170)2.43491434
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43346391
96reflex (GO:0060004)2.42398774
97peptidyl-tyrosine autophosphorylation (GO:0038083)2.41765348
98negative regulation of protein activation cascade (GO:2000258)2.41417329
99regulation of hexokinase activity (GO:1903299)2.40636436
100regulation of glucokinase activity (GO:0033131)2.40636436
101auditory receptor cell stereocilium organization (GO:0060088)2.39477025
102dermatan sulfate metabolic process (GO:0030205)2.39015040
103endoderm formation (GO:0001706)2.38632109
104face morphogenesis (GO:0060325)2.38508730
105negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.38287660
106fucose catabolic process (GO:0019317)2.37083952
107L-fucose metabolic process (GO:0042354)2.37083952
108L-fucose catabolic process (GO:0042355)2.37083952
109peripheral nervous system development (GO:0007422)2.36205917
110nephron epithelium morphogenesis (GO:0072088)2.36189629
111nephron tubule morphogenesis (GO:0072078)2.36189629
112keratinocyte development (GO:0003334)2.35258110
113glycerophospholipid catabolic process (GO:0046475)2.35034660
114protein K11-linked deubiquitination (GO:0035871)2.34956649
115oxygen transport (GO:0015671)2.34785056
116mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34210470
117mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34210470
118prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.33454863
119cellular response to calcium ion (GO:0071277)2.32185400
120mesenchymal cell differentiation (GO:0048762)2.30892895
121anatomical structure arrangement (GO:0048532)2.29615988
122regulation of mRNA 3-end processing (GO:0031440)2.29371854
123male sex determination (GO:0030238)2.29208848
124platelet dense granule organization (GO:0060155)2.28465961
125sex determination (GO:0007530)2.28378715
126photoreceptor cell maintenance (GO:0045494)2.27904013
127cyclic nucleotide catabolic process (GO:0009214)2.26971952
128response to laminar fluid shear stress (GO:0034616)2.26702013
129limb bud formation (GO:0060174)2.25766753
130toxin transport (GO:1901998)2.24667290
131lymphangiogenesis (GO:0001946)2.24553019
132type B pancreatic cell development (GO:0003323)2.24326285
133inositol phosphate catabolic process (GO:0071545)2.23873639
134positive regulation of glycogen metabolic process (GO:0070875)2.23691174
135positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.23406849
136interleukin-6-mediated signaling pathway (GO:0070102)2.23218550
137ketone body metabolic process (GO:1902224)2.23033705
138* response to gonadotropin (GO:0034698)2.23014760
139cAMP catabolic process (GO:0006198)2.22622553
140radial glial cell differentiation (GO:0060019)2.22250462
141venous blood vessel morphogenesis (GO:0048845)2.22011127
142regulation of cilium movement (GO:0003352)2.20918953
143regulation of monocyte differentiation (GO:0045655)2.19945432
144positive regulation of peptide hormone secretion (GO:0090277)2.19632990
145Sertoli cell development (GO:0060009)2.19274825
146nitric oxide mediated signal transduction (GO:0007263)2.18925187
147pathway-restricted SMAD protein phosphorylation (GO:0060389)2.17716806
148endothelial cell morphogenesis (GO:0001886)2.17142707
149viral protein processing (GO:0019082)2.16620773
150negative regulation of inclusion body assembly (GO:0090084)2.16209440
151regulation of gamma-delta T cell activation (GO:0046643)2.14435431
152regulation of gamma-delta T cell differentiation (GO:0045586)2.13250502
153surfactant homeostasis (GO:0043129)2.13054296
154positive regulation of vasculogenesis (GO:2001214)2.12993121
155mitotic cell cycle arrest (GO:0071850)2.12964315
156regulation of interleukin-12 biosynthetic process (GO:0045075)2.11671514
157macrophage activation (GO:0042116)2.11490596
158positive regulation of mRNA processing (GO:0050685)2.11002163
159endothelium development (GO:0003158)2.10687778
160heart valve morphogenesis (GO:0003179)2.10261484
161sleep (GO:0030431)2.10096236
162* regulation of cell proliferation involved in kidney development (GO:1901722)2.09395819
163cellular response to fluid shear stress (GO:0071498)2.09336384
164definitive hemopoiesis (GO:0060216)2.08924760
165trophoblast giant cell differentiation (GO:0060707)2.08881265
166protein heterotrimerization (GO:0070208)2.08526173
167negative regulation of T cell differentiation in thymus (GO:0033085)2.08047823
168negative regulation of smooth muscle contraction (GO:0045986)2.06972632
169mesodermal cell differentiation (GO:0048333)2.06302466
170vascular endothelial growth factor signaling pathway (GO:0038084)2.06087375
171response to fluid shear stress (GO:0034405)2.05057902
172platelet-derived growth factor receptor signaling pathway (GO:0048008)2.03718425
173regulation of somitogenesis (GO:0014807)2.01643900
174negative regulation of norepinephrine secretion (GO:0010700)2.00796799
175metanephric mesenchyme development (GO:0072075)2.00767181
176monocyte differentiation (GO:0030224)2.00699442
177peripheral nervous system axon ensheathment (GO:0032292)2.00536787
178myelination in peripheral nervous system (GO:0022011)2.00536787
179gas transport (GO:0015669)1.99256881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.38202604
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22253602
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.31020329
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.29928764
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.28191119
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23123465
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.22446926
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16835795
9ZNF274_21170338_ChIP-Seq_K562_Hela2.14551469
10AR_21572438_ChIP-Seq_LNCaP_Human2.11107444
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.05519276
12* TRIM28_21343339_ChIP-Seq_HEK293_Human2.00201370
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99056237
14GBX2_23144817_ChIP-Seq_PC3_Human1.93298236
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90526546
16FUS_26573619_Chip-Seq_HEK293_Human1.90339613
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90089535
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.89686643
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88860351
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.87473974
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85961176
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85666210
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83722502
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83400619
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78448806
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.76536565
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74131459
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74131459
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71656231
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69087548
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68322680
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61598822
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59960417
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59102854
35* AR_25329375_ChIP-Seq_VCAP_Human1.58323315
36AHR_22903824_ChIP-Seq_MCF-7_Human1.57389727
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.56046838
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55186156
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54404007
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.54035300
41TP53_18474530_ChIP-ChIP_U2OS_Human1.53394949
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52035645
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51725894
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51725894
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51725894
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.51168591
47* CLOCK_20551151_ChIP-Seq_293T_Human1.51097622
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.50322038
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50157544
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49865368
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49190376
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.49074114
53CJUN_26792858_Chip-Seq_BT549_Human1.48155159
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.47479223
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47047195
56* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44861434
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44295440
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43897607
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41961119
60ER_23166858_ChIP-Seq_MCF-7_Human1.41533294
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41502298
62* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39716836
63TP53_16413492_ChIP-PET_HCT116_Human1.38375014
64RUNX_20019798_ChIP-Seq_JUKART_Human1.38159313
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36724494
66* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35814374
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35767991
68VDR_22108803_ChIP-Seq_LS180_Human1.35001705
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.34543049
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34029239
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34029239
72EWS_26573619_Chip-Seq_HEK293_Human1.33169882
73STAT3_23295773_ChIP-Seq_U87_Human1.32408043
74* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30775045
75* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30505427
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.28906754
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27710172
78TCF4_22108803_ChIP-Seq_LS180_Human1.26721782
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.23575639
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.22727430
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.21259764
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20245367
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19968293
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19968293
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.18493289
86TCF4_23295773_ChIP-Seq_U87_Human1.18405265
87DROSHA_22980978_ChIP-Seq_HELA_Human1.18096523
88CBP_20019798_ChIP-Seq_JUKART_Human1.17390781
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17390781
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17155697
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17125843
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.16952388
93P300_19829295_ChIP-Seq_ESCs_Human1.14547079
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13892764
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13691378
96EZH2_22144423_ChIP-Seq_EOC_Human1.12684298
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12282873
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11251283
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.10800010
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.10499529
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10331804
102RUNX2_22187159_ChIP-Seq_PCA_Human1.09368286
103SMAD4_21799915_ChIP-Seq_A2780_Human1.09020894
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08492150
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08454708
106IGF1R_20145208_ChIP-Seq_DFB_Human1.08424410
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08144067
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08065358
109TAF15_26573619_Chip-Seq_HEK293_Human1.07766767
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07672948
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07501825
112* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06712392
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06475180
114REST_21632747_ChIP-Seq_MESCs_Mouse1.05795314
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05018189
116* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04286296
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03887419
118* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03573129
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03303315
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02946157
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02330774
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02033829
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02015576
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.01814774
125SCL_19346495_ChIP-Seq_HPC-7_Human1.01725156
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.01618718
127CDX2_22108803_ChIP-Seq_LS180_Human1.01566795
128RXR_22108803_ChIP-Seq_LS180_Human1.00284281
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99399138
130* EGR1_19374776_ChIP-ChIP_THP-1_Human0.99145980
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97906020
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.97889187
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97387430
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.96216699
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95625311
136SOX2_20726797_ChIP-Seq_SW620_Human0.94282190
137BCAT_22108803_ChIP-Seq_LS180_Human0.93579606
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93538842
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93397877
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92911300
141RNF2_27304074_Chip-Seq_NSC_Mouse0.91997985
142* RING1B_27294783_Chip-Seq_ESCs_Mouse0.91605340
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90913916
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.90474214
145VDR_24787735_ChIP-Seq_THP-1_Human0.90151300
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89299933
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88867254
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88639708
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88496360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.91811267
2MP0005503_abnormal_tendon_morphology3.60044694
3MP0003724_increased_susceptibility_to3.43594001
4MP0008438_abnormal_cutaneous_collagen2.90547350
5MP0002009_preneoplasia2.88384398
6MP0003195_calcinosis2.78696844
7MP0006072_abnormal_retinal_apoptosis2.62530870
8MP0003828_pulmonary_edema2.54105289
9MP0002254_reproductive_system_inflammat2.49501108
10MP0003283_abnormal_digestive_organ2.46471242
11MP0001879_abnormal_lymphatic_vessel2.46372284
12MP0001851_eye_inflammation2.42272015
13MP0001501_abnormal_sleep_pattern2.36722625
14MP0005275_abnormal_skin_tensile2.35848964
15MP0005379_endocrine/exocrine_gland_phen2.32752364
16MP0004272_abnormal_basement_membrane2.30274763
17MP0003787_abnormal_imprinting2.22845145
18MP0004885_abnormal_endolymph2.08775306
19MP0001944_abnormal_pancreas_morphology2.07290233
20MP0005508_abnormal_skeleton_morphology2.05756017
21MP0002837_dystrophic_cardiac_calcinosis2.02370969
22MP0002909_abnormal_adrenal_gland2.00630607
23MP0003279_aneurysm1.89335886
24MP0003941_abnormal_skin_development1.86062184
25MP0000678_abnormal_parathyroid_gland1.79882005
26MP0008995_early_reproductive_senescence1.79074371
27MP0001984_abnormal_olfaction1.77424875
28MP0002163_abnormal_gland_morphology1.72888628
29MP0002876_abnormal_thyroid_physiology1.72704786
30MP0005187_abnormal_penis_morphology1.70928476
31MP0005551_abnormal_eye_electrophysiolog1.70097401
32MP0000049_abnormal_middle_ear1.69665165
33MP0002108_abnormal_muscle_morphology1.69117011
34MP0002877_abnormal_melanocyte_morpholog1.67126064
35MP0001346_abnormal_lacrimal_gland1.66723079
36MP0003943_abnormal_hepatobiliary_system1.65740970
37* MP0000631_abnormal_neuroendocrine_gland1.64639115
38MP0000566_synostosis1.63913367
39MP0005409_darkened_coat_color1.62658992
40MP0005423_abnormal_somatic_nervous1.60838129
41MP0004742_abnormal_vestibular_system1.60265397
42MP0005253_abnormal_eye_physiology1.59934205
43MP0002060_abnormal_skin_morphology1.54947076
44MP0005390_skeleton_phenotype1.53045483
45MP0009384_cardiac_valve_regurgitation1.49972558
46MP0003763_abnormal_thymus_physiology1.49237473
47MP0010329_abnormal_lipoprotein_level1.47859171
48MP0001188_hyperpigmentation1.47855652
49* MP0002557_abnormal_social/conspecific_i1.47853767
50MP0000613_abnormal_salivary_gland1.47220487
51MP0002938_white_spotting1.45788224
52MP0002998_abnormal_bone_remodeling1.45721360
53MP0001486_abnormal_startle_reflex1.44607277
54MP0002693_abnormal_pancreas_physiology1.43891665
55MP0000427_abnormal_hair_cycle1.43005328
56MP0010678_abnormal_skin_adnexa1.38030972
57MP0009745_abnormal_behavioral_response1.36051493
58MP0000538_abnormal_urinary_bladder1.35221152
59MP0001756_abnormal_urination1.33723738
60MP0002295_abnormal_pulmonary_circulatio1.32849250
61MP0009278_abnormal_bone_marrow1.32320108
62MP0002933_joint_inflammation1.32200289
63MP0000639_abnormal_adrenal_gland1.32050401
64MP0002638_abnormal_pupillary_reflex1.30458801
65MP0000516_abnormal_urinary_system1.30448638
66MP0005367_renal/urinary_system_phenotyp1.30448638
67MP0009046_muscle_twitch1.30051153
68MP0003122_maternal_imprinting1.28094986
69MP0000163_abnormal_cartilage_morphology1.27368162
70MP0002896_abnormal_bone_mineralization1.27166161
71MP0004133_heterotaxia1.26792282
72MP0005084_abnormal_gallbladder_morpholo1.25718977
73MP0004381_abnormal_hair_follicle1.25510823
74MP0010234_abnormal_vibrissa_follicle1.24591551
75MP0005220_abnormal_exocrine_pancreas1.22033782
76MP0000767_abnormal_smooth_muscle1.21965602
77MP0005248_abnormal_Harderian_gland1.21041697
78MP0005171_absent_coat_pigmentation1.20693454
79MP0002272_abnormal_nervous_system1.19960936
80MP0002928_abnormal_bile_duct1.18903002
81MP0004043_abnormal_pH_regulation1.18673347
82MP0001502_abnormal_circadian_rhythm1.17681137
83MP0009250_abnormal_appendicular_skeleto1.16637308
84MP0001533_abnormal_skeleton_physiology1.15956374
85MP0005388_respiratory_system_phenotype1.14907234
86MP0002133_abnormal_respiratory_system1.14907234
87MP0009780_abnormal_chondrocyte_physiolo1.13972644
88MP0002249_abnormal_larynx_morphology1.13929273
89MP0004510_myositis1.12947210
90MP0008961_abnormal_basal_metabolism1.12388261
91MP0000647_abnormal_sebaceous_gland1.11095063
92MP0003136_yellow_coat_color1.10677825
93MP0003300_gastrointestinal_ulcer1.10255942
94MP0003045_fibrosis1.07829972
95MP0000762_abnormal_tongue_morphology1.07158238
96MP0001958_emphysema1.06820359
97MP0001485_abnormal_pinna_reflex1.05149085
98MP0002089_abnormal_postnatal_growth/wei1.04769266
99MP0001542_abnormal_bone_strength1.04442803
100MP0000778_abnormal_nervous_system1.03602767
101MP0005645_abnormal_hypothalamus_physiol1.02589888
102MP0002168_other_aberrant_phenotype1.01961028
103MP0005595_abnormal_vascular_smooth1.00184844
104* MP0003795_abnormal_bone_structure0.99755405
105MP0002116_abnormal_craniofacial_bone0.99613798
106* MP0004883_abnormal_blood_vessel0.99557319
107* MP0002572_abnormal_emotion/affect_behav0.98451454
108MP0001340_abnormal_eyelid_morphology0.98142511
109MP0008004_abnormal_stomach_pH0.96195283
110MP0000383_abnormal_hair_follicle0.96132091
111MP0001270_distended_abdomen0.93898537
112* MP0005646_abnormal_pituitary_gland0.93642699
113MP0002064_seizures0.92871715
114MP0002078_abnormal_glucose_homeostasis0.92740256
115MP0004924_abnormal_behavior0.92328482
116MP0005386_behavior/neurological_phenoty0.92328482
117MP0002138_abnormal_hepatobiliary_system0.91999946
118MP0008877_abnormal_DNA_methylation0.91828745
119MP0004019_abnormal_vitamin_homeostasis0.91804015
120MP0002102_abnormal_ear_morphology0.91647660
121MP0005448_abnormal_energy_balance0.90937857
122MP0006276_abnormal_autonomic_nervous0.90936351
123MP0005165_increased_susceptibility_to0.89938243
124MP0002115_abnormal_skeleton_extremities0.89044623
125MP0000003_abnormal_adipose_tissue0.88966444
126MP0001177_atelectasis0.88322100
127MP0009379_abnormal_foot_pigmentation0.86584967
128* MP0005164_abnormal_response_to0.86288592
129MP0000534_abnormal_ureter_morphology0.86226109
130MP0008789_abnormal_olfactory_epithelium0.85298262
131MP0002113_abnormal_skeleton_development0.85166590
132MP0000026_abnormal_inner_ear0.84779813
133MP0004484_altered_response_of0.82542290
134MP0003880_abnormal_central_pattern0.82435884
135MP0004142_abnormal_muscle_tone0.81311837
136MP0004085_abnormal_heartbeat0.80882735
137MP0008875_abnormal_xenobiotic_pharmacok0.79777950
138MP0002166_altered_tumor_susceptibility0.78897956
139MP0004270_analgesia0.77832677
140MP0003890_abnormal_embryonic-extraembry0.77467706
141MP0005310_abnormal_salivary_gland0.77064688
142MP0004147_increased_porphyrin_level0.76754554
143* MP0003953_abnormal_hormone_level0.75703742
144MP0001853_heart_inflammation0.74693908
145MP0002233_abnormal_nose_morphology0.74289095
146MP0002277_abnormal_respiratory_mucosa0.73753732
147MP0003385_abnormal_body_wall0.73173183
148MP0002282_abnormal_trachea_morphology0.72997352
149MP0001963_abnormal_hearing_physiology0.72870910
150MP0002177_abnormal_outer_ear0.72128631
151MP0001970_abnormal_pain_threshold0.71854851
152MP0002736_abnormal_nociception_after0.71590667
153MP0001968_abnormal_touch/_nociception0.70993371
154MP0000013_abnormal_adipose_tissue0.70909248
155MP0005257_abnormal_intraocular_pressure0.70139706
156MP0002069_abnormal_eating/drinking_beha0.69814102
157MP0003633_abnormal_nervous_system0.69675439
158MP0003942_abnormal_urinary_system0.69465993
159MP0003755_abnormal_palate_morphology0.69460375
160MP0005365_abnormal_bile_salt0.69441124
161MP0006292_abnormal_olfactory_placode0.69391422
162MP0001790_abnormal_immune_system0.69146889
163MP0005387_immune_system_phenotype0.69146889
164MP0002109_abnormal_limb_morphology0.68305458
165MP0003453_abnormal_keratinocyte_physiol0.67867348
166MP0010386_abnormal_urinary_bladder0.67455062
167MP0000470_abnormal_stomach_morphology0.67439063
168MP0004782_abnormal_surfactant_physiolog0.67034549
169MP0002932_abnormal_joint_morphology0.66859362

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)4.70594174
2Ulnar claw (HP:0001178)4.68531488
3Segmental peripheral demyelination/remyelination (HP:0003481)3.92783199
4Upper limb muscle weakness (HP:0003484)3.83078965
5Vascular tortuosity (HP:0004948)3.57068945
6Hemiparesis (HP:0001269)3.55145820
7Peripheral hypomyelination (HP:0007182)3.41881376
8Large for gestational age (HP:0001520)3.36828054
9Arterial tortuosity (HP:0005116)3.30792541
10Hypothermia (HP:0002045)3.21797786
11Abnormal sex determination (HP:0012244)3.21065710
12Sex reversal (HP:0012245)3.21065710
13Intestinal atresia (HP:0011100)3.09541929
14Hyperglycemia (HP:0003074)3.09497182
15Prostate neoplasm (HP:0100787)3.09049217
16Broad metatarsal (HP:0001783)3.07686664
17Hyperinsulinemic hypoglycemia (HP:0000825)3.02328020
18Pancreatic cysts (HP:0001737)3.00714580
19Congenital sensorineural hearing impairment (HP:0008527)2.96767896
20Hyperventilation (HP:0002883)2.94219305
21Hypoglycemic seizures (HP:0002173)2.92892272
22Pancreatic fibrosis (HP:0100732)2.89557102
23Obstructive sleep apnea (HP:0002870)2.89489493
24Medial flaring of the eyebrow (HP:0010747)2.73354369
25Abnormality of the metopic suture (HP:0005556)2.67952629
26Ketoacidosis (HP:0001993)2.65823343
27Enlarged penis (HP:0000040)2.65487434
28Abnormality of the nasal septum (HP:0000419)2.64059665
29Lip pit (HP:0100267)2.63290056
30Aqueductal stenosis (HP:0002410)2.62320693
31Bone cyst (HP:0012062)2.54549115
32Cystic liver disease (HP:0006706)2.52890056
33Abnormality of incisor morphology (HP:0011063)2.51043054
34Alveolar cell carcinoma (HP:0006519)2.50454086
35Hypoglycemic coma (HP:0001325)2.49682865
36Aortic aneurysm (HP:0004942)2.47876853
37Cervical subluxation (HP:0003308)2.47524203
38Aortic valve stenosis (HP:0001650)2.42697479
39Abnormality of the renal cortex (HP:0011035)2.39667026
40Nephronophthisis (HP:0000090)2.37696952
41Submucous cleft hard palate (HP:0000176)2.36096254
42EEG with generalized epileptiform discharges (HP:0011198)2.35465451
43Abnormality of the renal medulla (HP:0100957)2.34481371
44J-shaped sella turcica (HP:0002680)2.32223138
45Hypsarrhythmia (HP:0002521)2.31401735
46Tubular atrophy (HP:0000092)2.31356124
47Pulmonary artery stenosis (HP:0004415)2.29853494
48Abnormality of the labia minora (HP:0012880)2.29386258
49Follicular hyperkeratosis (HP:0007502)2.29261237
50Congenital primary aphakia (HP:0007707)2.29185984
51Neoplasm of the tracheobronchial system (HP:0100552)2.28287012
52Gait imbalance (HP:0002141)2.27823889
53Epileptiform EEG discharges (HP:0011182)2.25799713
54Hypoplastic labia majora (HP:0000059)2.24703109
55Urethral obstruction (HP:0000796)2.21483264
56Aplasia involving bones of the extremities (HP:0009825)2.19633619
57Aplasia involving bones of the upper limbs (HP:0009823)2.19633619
58Aplasia of the phalanges of the hand (HP:0009802)2.19633619
59Labial hypoplasia (HP:0000066)2.18413828
60Hypomagnesemia (HP:0002917)2.17635783
61Widely spaced teeth (HP:0000687)2.17097459
62Abnormality of midbrain morphology (HP:0002418)2.16965973
63Molar tooth sign on MRI (HP:0002419)2.16965973
64Abnormality of endocrine pancreas physiology (HP:0012093)2.14805735
65Abnormality of the pancreatic islet cells (HP:0006476)2.14805735
66Abnormality of molar (HP:0011077)2.13563283
67Abnormality of molar morphology (HP:0011070)2.13563283
68Hematochezia (HP:0002573)2.13113767
69White forelock (HP:0002211)2.12742797
70Cupped ear (HP:0000378)2.12341350
71Laryngomalacia (HP:0001601)2.12296198
72Epiphyseal dysplasia (HP:0002656)2.11944383
73Spondylolisthesis (HP:0003302)2.11670653
74Polydipsia (HP:0001959)2.09547806
75Abnormal drinking behavior (HP:0030082)2.09547806
76Flared iliac wings (HP:0002869)2.08707302
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08210051
78Abnormality of the labia majora (HP:0012881)2.08139352
79Absent speech (HP:0001344)2.07752572
80Ketosis (HP:0001946)2.07508311
81Impaired proprioception (HP:0010831)2.05685861
82Median cleft lip (HP:0000161)2.04154964
83Gastrointestinal atresia (HP:0002589)2.03797372
84Nasolacrimal duct obstruction (HP:0000579)2.03197324
85Thickened helices (HP:0000391)2.02434368
86Disproportionate tall stature (HP:0001519)2.01260531
87Prominent supraorbital ridges (HP:0000336)2.00600912
88Hypoplastic female external genitalia (HP:0012815)1.99930763
89Aortic dissection (HP:0002647)1.99667606
90Nephrogenic diabetes insipidus (HP:0009806)1.99625072
91Hepatoblastoma (HP:0002884)1.98416701
92Mixed hearing impairment (HP:0000410)1.98200113
93Lymphangioma (HP:0100764)1.98043361
94Downturned corners of mouth (HP:0002714)1.97431536
95Congenital stationary night blindness (HP:0007642)1.96364076
96Hamartoma of the eye (HP:0010568)1.96109935
97Short hallux (HP:0010109)1.95634735
98Optic nerve hypoplasia (HP:0000609)1.95009653
99Bell-shaped thorax (HP:0001591)1.94993067
100Adrenal hypoplasia (HP:0000835)1.94876198
101Corneal dystrophy (HP:0001131)1.93334857
102Broad foot (HP:0001769)1.92941765
103Patchy hypopigmentation of hair (HP:0011365)1.92890138
104Genital tract atresia (HP:0001827)1.92851753
105Sleep apnea (HP:0010535)1.92473271
106Occipital encephalocele (HP:0002085)1.92290247
107Growth hormone excess (HP:0000845)1.92200020
108Attenuation of retinal blood vessels (HP:0007843)1.91585689
109Increased corneal curvature (HP:0100692)1.90720353
110Keratoconus (HP:0000563)1.90720353
111Increased CSF protein (HP:0002922)1.90029795
112Male pseudohermaphroditism (HP:0000037)1.89704054
113Abnormality of the dental root (HP:0006486)1.89425209
114Taurodontia (HP:0000679)1.89425209
115Abnormality of permanent molar morphology (HP:0011071)1.89425209
116Neoplasm of the heart (HP:0100544)1.89280504
117Neoplasm of the adrenal cortex (HP:0100641)1.88462879
118Hypoplastic iliac wings (HP:0002866)1.88338576
119Type II lissencephaly (HP:0007260)1.87632115
120Conical tooth (HP:0000698)1.85932343
121Abnormal rod and cone electroretinograms (HP:0008323)1.85909830
122Atrophic scars (HP:0001075)1.84195249
123Onion bulb formation (HP:0003383)1.84125156
124Congenital malformation of the right heart (HP:0011723)1.83671249
125Double outlet right ventricle (HP:0001719)1.83671249
126Distal lower limb muscle weakness (HP:0009053)1.83510946
127Furrowed tongue (HP:0000221)1.80837404
128Prominent metopic ridge (HP:0005487)1.80717488
129Fibular hypoplasia (HP:0003038)1.80593600
130Steppage gait (HP:0003376)1.80173017
131Insulin-resistant diabetes mellitus (HP:0000831)1.79395453
132Abnormality of the nasolacrimal system (HP:0000614)1.78234989
133Postaxial hand polydactyly (HP:0001162)1.77863734
134Abnormality of the dental pulp (HP:0006479)1.77828485
135Abnormality of the middle phalanges of the toes (HP:0010183)1.76965280
136Milia (HP:0001056)1.76654023
137Synostosis involving the elbow (HP:0003938)1.76270100
138Humeroradial synostosis (HP:0003041)1.76270100
139Bulbous nose (HP:0000414)1.75867903
140Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75603071
141Scrotal hypoplasia (HP:0000046)1.75448003
142Gaze-evoked nystagmus (HP:0000640)1.74893078
143Short metatarsal (HP:0010743)1.74801081
144Aplasia/hypoplasia of the uterus (HP:0008684)1.73443390
145Vaginal atresia (HP:0000148)1.73285170
146Hypoplastic ischia (HP:0003175)1.72835487
147Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72759092
148Short 4th metacarpal (HP:0010044)1.72759092
149Accelerated skeletal maturation (HP:0005616)1.72067507
150Albinism (HP:0001022)1.71455372
151Broad face (HP:0000283)1.70539783
152Abnormality of the ischium (HP:0003174)1.70293163
153Abnormality of the labia (HP:0000058)1.70232005
154Hypoplasia of the odontoid process (HP:0003311)1.69615430
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.69378418
156Dysostosis multiplex (HP:0000943)1.69135933
157Cranial hyperostosis (HP:0004437)1.68879678
158Bronchomalacia (HP:0002780)1.68580912
159Abnormality of the lacrimal duct (HP:0011481)1.68532348
160Abnormal ciliary motility (HP:0012262)1.68370627
161Premature rupture of membranes (HP:0001788)1.68349835
162Febrile seizures (HP:0002373)1.68234305
163Cerebral aneurysm (HP:0004944)1.68145347
164Progressive cerebellar ataxia (HP:0002073)1.67903873
165Abnormality of vitamin B metabolism (HP:0004340)1.67833938
166Disproportionate short-trunk short stature (HP:0003521)1.67322280
167Abnormal respiratory motile cilium physiology (HP:0012261)1.66249870
168Abnormality of the femoral head (HP:0003368)1.63810504
169Spontaneous hematomas (HP:0007420)1.63248861
170Craniofacial hyperostosis (HP:0004493)1.62868689
171True hermaphroditism (HP:0010459)1.61939458
172Flat capital femoral epiphysis (HP:0003370)1.61093069
173Neonatal short-limb short stature (HP:0008921)1.60833308
174Premature skin wrinkling (HP:0100678)1.59828426
175Abnormality of the fovea (HP:0000493)1.57936531
176Aplasia/Hypoplasia of the hallux (HP:0008362)1.57575414
177Joint stiffness (HP:0001387)1.57471195
178Nephropathy (HP:0000112)1.57369172
179Aplasia/Hypoplasia of the fovea (HP:0008060)1.56638903
180Hypoplasia of the fovea (HP:0007750)1.56638903
181Aplasia cutis congenita (HP:0001057)1.55011093
182Shallow orbits (HP:0000586)1.54713205
183Hypoplasia of the iris (HP:0007676)1.53737865
184Xerostomia (HP:0000217)1.53480164
185Bifid scrotum (HP:0000048)1.53122814
186Down-sloping shoulders (HP:0200021)1.50854115
187Asymmetry of the thorax (HP:0001555)1.50804143
188Full cheeks (HP:0000293)1.48796219
189Systemic lupus erythematosus (HP:0002725)1.48769286
190Abnormality of the odontoid process (HP:0003310)1.47907544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.16696275
2TGFBR23.72673207
3TIE13.24926768
4MAP2K22.73156821
5MAP4K22.44328477
6PNCK2.39234061
7MAPK72.05983945
8PIM22.00480176
9VRK11.92331013
10BMPR21.88312131
11GRK71.85849814
12STK38L1.76649023
13NLK1.76131504
14MAPKAPK51.75420228
15MAP3K141.71985848
16TNIK1.66602928
17WEE11.65683109
18EPHB11.63350767
19NEK61.62270977
20INSRR1.59071032
21EPHA31.57036043
22TXK1.56583888
23BMPR1B1.54607316
24CDK31.52135106
25IKBKB1.45550558
26MAP3K31.36397840
27HIPK21.35708460
28STK391.34162201
29BRSK21.33115207
30CASK1.29139487
31WNK31.28764402
32PHKG11.28149088
33PHKG21.28149088
34CHUK1.25815027
35IKBKE1.18257977
36SIK31.15084381
37DMPK1.14515359
38PRKD31.13893844
39TGFBR11.12736819
40CDK81.10882479
41RPS6KA51.08160139
42DAPK21.07704014
43NTRK31.06743337
44IRAK11.06552979
45FGFR21.06347568
46MAP3K41.05155407
47ITK0.99857187
48MAP3K20.99055549
49PRPF4B0.98472300
50NUAK10.97855891
51PAK20.95074778
52CSNK1G10.93889181
53SGK20.93593195
54FER0.90864913
55RPS6KA20.89996155
56TRPM70.89027538
57WNK40.88268341
58TNK20.87899328
59MST40.87386413
60GSK3A0.86709056
61PINK10.86474762
62LATS10.84360356
63MAPK130.83558890
64STK30.81330063
65TSSK60.79981931
66PTK2B0.79349906
67SGK4940.78761013
68SGK2230.78761013
69TEC0.77645649
70KDR0.77380947
71FRK0.75817286
72ERBB30.75671291
73ROCK10.75090863
74MAP3K70.74600933
75MAP4K10.73091821
76EPHA40.72696422
77PDGFRB0.71675783
78ADRBK20.71232547
79PASK0.69178391
80MAPKAPK20.68773994
81OXSR10.65552303
82PRKCG0.65415142
83RPS6KA60.65395199
84GRK10.64732650
85MAP2K70.64399680
86STK100.63896427
87ZAK0.63844251
88FGFR30.63400276
89IRAK40.63173108
90EPHA20.61642312
91MKNK20.61614827
92SGK30.60934324
93FGFR40.60467081
94IRAK30.59928900
95RPS6KL10.58855272
96RPS6KC10.58855272
97PDGFRA0.57802023
98FGFR10.57753960
99NTRK20.57579849
100AKT30.57189174
101CDK90.55365326
102PRKCE0.54944862
103MOS0.53764499
104CSNK1G30.53383835
105JAK30.51711229
106ACVR1B0.51571903
107DYRK20.51053131
108TAOK30.50363787
109CLK10.50349246
110MAP3K10.50181881
111RPS6KA10.50174861
112GRK50.48129625
113ERBB20.48115430
114MAPK30.47983742
115IRAK20.47575741
116PKN10.45601610
117CSNK1G20.45122728
118MKNK10.44594613
119PRKD20.43459531
120PRKCH0.42959487
121CSNK1A1L0.42890905
122CAMK40.42562456
123MAP2K60.42501232
124PRKCZ0.42428603
125PRKAA10.41556772
126PRKG20.40909378
127BRD40.39665476
128STK110.39648191
129ROCK20.39308784
130CAMK2D0.38849023
131MAPK10.38616232
132ZAP700.37671683
133MAPK40.37266746
134PLK20.37068223
135PRKAA20.35851324
136PLK30.35466410
137YES10.35408938
138PRKD10.35102192
139MELK0.35043582
140MARK10.34970960
141CAMK1G0.34842372
142PDK20.34394156
143EIF2AK20.34341649
144RPS6KA40.34064236
145RIPK10.33525205
146EPHB20.32284720
147JAK10.31504562
148PAK30.30199242
149MAP2K10.29606124

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.09887189
2Butanoate metabolism_Homo sapiens_hsa006502.52192977
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26724600
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98361235
5Osteoclast differentiation_Homo sapiens_hsa043801.82282579
6ECM-receptor interaction_Homo sapiens_hsa045121.81041936
7Cocaine addiction_Homo sapiens_hsa050301.65114034
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63528861
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63210050
10Phototransduction_Homo sapiens_hsa047441.61836577
11Amphetamine addiction_Homo sapiens_hsa050311.57040668
12Nitrogen metabolism_Homo sapiens_hsa009101.53793641
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.47078997
14TNF signaling pathway_Homo sapiens_hsa046681.45962808
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37618715
16Leishmaniasis_Homo sapiens_hsa051401.37616369
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.36953367
18Collecting duct acid secretion_Homo sapiens_hsa049661.35011059
19TGF-beta signaling pathway_Homo sapiens_hsa043501.27954924
20Prolactin signaling pathway_Homo sapiens_hsa049171.27514222
21Circadian rhythm_Homo sapiens_hsa047101.26933887
22* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24053917
23Rheumatoid arthritis_Homo sapiens_hsa053231.23121995
24Linoleic acid metabolism_Homo sapiens_hsa005911.22767275
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22642340
26MAPK signaling pathway_Homo sapiens_hsa040101.19733436
27T cell receptor signaling pathway_Homo sapiens_hsa046601.19200441
28African trypanosomiasis_Homo sapiens_hsa051431.17048607
29Focal adhesion_Homo sapiens_hsa045101.14184464
30Protein export_Homo sapiens_hsa030601.14114155
31Renin secretion_Homo sapiens_hsa049241.13735133
32Estrogen signaling pathway_Homo sapiens_hsa049151.13446744
33Toxoplasmosis_Homo sapiens_hsa051451.12662814
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.12261054
35Hepatitis B_Homo sapiens_hsa051611.12255333
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12038759
37Hedgehog signaling pathway_Homo sapiens_hsa043401.12035184
38Malaria_Homo sapiens_hsa051441.12027470
39Tryptophan metabolism_Homo sapiens_hsa003801.10771838
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10476756
41Notch signaling pathway_Homo sapiens_hsa043301.09627290
42Circadian entrainment_Homo sapiens_hsa047131.08548375
43Prostate cancer_Homo sapiens_hsa052151.08348219
44Pertussis_Homo sapiens_hsa051331.07889076
45Mineral absorption_Homo sapiens_hsa049781.07124858
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04619894
47Insulin secretion_Homo sapiens_hsa049111.03640145
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03199558
49Folate biosynthesis_Homo sapiens_hsa007901.02726825
50ABC transporters_Homo sapiens_hsa020101.01599282
51B cell receptor signaling pathway_Homo sapiens_hsa046621.00122391
52Dorso-ventral axis formation_Homo sapiens_hsa043200.99924111
53Dopaminergic synapse_Homo sapiens_hsa047280.99657115
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99519060
55Protein digestion and absorption_Homo sapiens_hsa049740.99008874
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.96906038
57Regulation of autophagy_Homo sapiens_hsa041400.94942654
58Adherens junction_Homo sapiens_hsa045200.93446846
59Wnt signaling pathway_Homo sapiens_hsa043100.93319788
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93257634
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92133850
62Glutamatergic synapse_Homo sapiens_hsa047240.91927416
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91082418
64Sulfur metabolism_Homo sapiens_hsa009200.90095695
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89430533
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89261813
67Serotonergic synapse_Homo sapiens_hsa047260.89245404
68cAMP signaling pathway_Homo sapiens_hsa040240.88473861
69Amoebiasis_Homo sapiens_hsa051460.87521420
70Selenocompound metabolism_Homo sapiens_hsa004500.87025692
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85894430
72Other glycan degradation_Homo sapiens_hsa005110.85530379
73GABAergic synapse_Homo sapiens_hsa047270.85439112
74GnRH signaling pathway_Homo sapiens_hsa049120.84300625
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.84284556
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83941057
77Choline metabolism in cancer_Homo sapiens_hsa052310.83889149
78Colorectal cancer_Homo sapiens_hsa052100.83846055
79Axon guidance_Homo sapiens_hsa043600.82085204
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81038711
81Vitamin B6 metabolism_Homo sapiens_hsa007500.80815223
82beta-Alanine metabolism_Homo sapiens_hsa004100.80157980
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80140744
84Cholinergic synapse_Homo sapiens_hsa047250.80064849
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79885619
86Propanoate metabolism_Homo sapiens_hsa006400.78696635
87Sphingolipid metabolism_Homo sapiens_hsa006000.78696303
88Lysine degradation_Homo sapiens_hsa003100.78263287
89Pancreatic secretion_Homo sapiens_hsa049720.77756938
90Pathways in cancer_Homo sapiens_hsa052000.76828688
91Nicotine addiction_Homo sapiens_hsa050330.76547964
92Thyroid hormone synthesis_Homo sapiens_hsa049180.75568548
93Type II diabetes mellitus_Homo sapiens_hsa049300.74941225
94Ovarian steroidogenesis_Homo sapiens_hsa049130.74691305
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73840854
96FoxO signaling pathway_Homo sapiens_hsa040680.73428318
97Salmonella infection_Homo sapiens_hsa051320.72693270
98Oxytocin signaling pathway_Homo sapiens_hsa049210.71603475
99* HTLV-I infection_Homo sapiens_hsa051660.71169291
100Ras signaling pathway_Homo sapiens_hsa040140.70741804
101ErbB signaling pathway_Homo sapiens_hsa040120.70501017
102Chronic myeloid leukemia_Homo sapiens_hsa052200.70493794
103Platelet activation_Homo sapiens_hsa046110.70489355
104Gastric acid secretion_Homo sapiens_hsa049710.70434178
105Rap1 signaling pathway_Homo sapiens_hsa040150.70312736
106Glucagon signaling pathway_Homo sapiens_hsa049220.68169899
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67470079
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66521288
109Small cell lung cancer_Homo sapiens_hsa052220.65906965
110Proteoglycans in cancer_Homo sapiens_hsa052050.65287349
111Morphine addiction_Homo sapiens_hsa050320.64986644
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.64757396
113Apoptosis_Homo sapiens_hsa042100.64629247
114Salivary secretion_Homo sapiens_hsa049700.64443114
115Ether lipid metabolism_Homo sapiens_hsa005650.64072078
116Complement and coagulation cascades_Homo sapiens_hsa046100.63701733
117Hematopoietic cell lineage_Homo sapiens_hsa046400.63370177
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62234715
119Dilated cardiomyopathy_Homo sapiens_hsa054140.61758005
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61750204
121Taste transduction_Homo sapiens_hsa047420.61616991
122Chemokine signaling pathway_Homo sapiens_hsa040620.61540776
123Long-term depression_Homo sapiens_hsa047300.61416257
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61326098
125Caffeine metabolism_Homo sapiens_hsa002320.61283545
126Acute myeloid leukemia_Homo sapiens_hsa052210.61001394
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.60417674
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60227594
129Melanogenesis_Homo sapiens_hsa049160.60149202
130Hippo signaling pathway_Homo sapiens_hsa043900.59699888
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.59013723
132Renal cell carcinoma_Homo sapiens_hsa052110.58912657
133Peroxisome_Homo sapiens_hsa041460.58481632
134Influenza A_Homo sapiens_hsa051640.58283181
135Insulin resistance_Homo sapiens_hsa049310.57752412
136Tight junction_Homo sapiens_hsa045300.56330011
137Bile secretion_Homo sapiens_hsa049760.56079481
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54814119
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54488517
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54485982
141Histidine metabolism_Homo sapiens_hsa003400.54290822
142Hepatitis C_Homo sapiens_hsa051600.53932483
143Chemical carcinogenesis_Homo sapiens_hsa052040.53927451
144Basal cell carcinoma_Homo sapiens_hsa052170.53887078
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53301028
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52009091
147Fatty acid elongation_Homo sapiens_hsa000620.50481259
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49623705
149mTOR signaling pathway_Homo sapiens_hsa041500.49032099
150AMPK signaling pathway_Homo sapiens_hsa041520.47942990
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41762186
152Retinol metabolism_Homo sapiens_hsa008300.41529610
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41323035
154Arachidonic acid metabolism_Homo sapiens_hsa005900.41002053
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.39249010

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