EGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)5.80388312
2regulation of interleukin-12 biosynthetic process (GO:0045075)4.85443879
3regulation of gamma-delta T cell differentiation (GO:0045586)4.62715648
4cellular extravasation (GO:0045123)4.49461726
5regulation of gamma-delta T cell activation (GO:0046643)4.47354596
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.45576215
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07077322
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.07077322
9modulation by symbiont of host immune response (GO:0052553)4.07077322
10positive regulation by symbiont of host defense response (GO:0052509)4.07077322
11modulation by symbiont of host defense response (GO:0052031)4.07077322
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07077322
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.79972522
14positive thymic T cell selection (GO:0045059)3.78735803
15response to muramyl dipeptide (GO:0032495)3.76443596
16myeloid dendritic cell differentiation (GO:0043011)3.73068256
17regulation of isotype switching to IgG isotypes (GO:0048302)3.72302315
18positive regulation of gamma-delta T cell activation (GO:0046645)3.71970730
19regulation of cell proliferation involved in kidney development (GO:1901722)3.68197848
20myeloid dendritic cell activation (GO:0001773)3.46973311
21regulation of T cell tolerance induction (GO:0002664)3.45745680
22activated T cell proliferation (GO:0050798)3.45227548
23interleukin-1-mediated signaling pathway (GO:0070498)3.44722080
24T cell migration (GO:0072678)3.43770319
25positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.43552630
26cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.41311713
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.41122108
28leukocyte aggregation (GO:0070486)3.39254435
29macrophage activation involved in immune response (GO:0002281)3.37846238
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32210460
31neutrophil activation involved in immune response (GO:0002283)3.27995492
32positive T cell selection (GO:0043368)3.26171552
33regulation of chronic inflammatory response (GO:0002676)3.25736776
34regulation of interleukin-2 biosynthetic process (GO:0045076)3.23791990
35regulation of vitamin metabolic process (GO:0030656)3.22940523
36microglial cell activation (GO:0001774)3.20805054
37CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20497725
38T-helper cell differentiation (GO:0042093)3.20497725
39regulation of immunoglobulin secretion (GO:0051023)3.20396184
40cell proliferation involved in kidney development (GO:0072111)3.19072446
41regulation of interleukin-2 production (GO:0032663)3.17889808
42positive regulation of astrocyte differentiation (GO:0048711)3.17241811
43positive regulation of interleukin-2 production (GO:0032743)3.13968835
44NIK/NF-kappaB signaling (GO:0038061)3.12392648
45thymic T cell selection (GO:0045061)3.05571910
46B cell homeostasis (GO:0001782)3.03248574
47cell migration involved in sprouting angiogenesis (GO:0002042)2.99647294
48negative thymic T cell selection (GO:0045060)2.98736002
49regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98230702
50T cell costimulation (GO:0031295)2.97360032
51negative T cell selection (GO:0043383)2.95341382
52response to protozoan (GO:0001562)2.94508248
53lymphocyte costimulation (GO:0031294)2.94216386
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91579037
55positive regulation of extracellular matrix organization (GO:1903055)2.91212120
56response to peptidoglycan (GO:0032494)2.91050752
57lung lobe morphogenesis (GO:0060463)2.90843659
58regulation of natural killer cell mediated immunity (GO:0002715)2.90789760
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90789760
60positive regulation of osteoclast differentiation (GO:0045672)2.88375907
61tyrosine phosphorylation of STAT protein (GO:0007260)2.88074735
62defense response to protozoan (GO:0042832)2.86741907
63regulation of monocyte differentiation (GO:0045655)2.86159584
64positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.84828438
65cellular response to interleukin-15 (GO:0071350)2.84804146
66T-helper 1 type immune response (GO:0042088)2.84599861
67oligosaccharide catabolic process (GO:0009313)2.83986250
68positive regulation of humoral immune response (GO:0002922)2.82511141
69regulation of B cell receptor signaling pathway (GO:0050855)2.82103852
70T cell differentiation involved in immune response (GO:0002292)2.81798275
71alpha-beta T cell differentiation involved in immune response (GO:0002293)2.81798275
72alpha-beta T cell activation involved in immune response (GO:0002287)2.81798275
73regulation of lymphocyte chemotaxis (GO:1901623)2.81303839
74macrophage activation (GO:0042116)2.80199302
75T cell selection (GO:0045058)2.80049301
76regulation of regulatory T cell differentiation (GO:0045589)2.79698062
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.79097333
78positive regulation of glomerulus development (GO:0090193)2.79065976
79cellular response to antibiotic (GO:0071236)2.77743581
80negative regulation of T cell mediated immunity (GO:0002710)2.76371699
81regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.76353653
82regulation of isotype switching (GO:0045191)2.75954902
83regulation of B cell mediated immunity (GO:0002712)2.75213276
84tolerance induction (GO:0002507)2.74910042
85regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.74685753
86positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.74685753
87myeloid cell activation involved in immune response (GO:0002275)2.74169995
88regulation of immunoglobulin mediated immune response (GO:0002889)2.74118729
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73701205
90positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73701205
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73667178
92regulation of tolerance induction (GO:0002643)2.73269053
93interferon-gamma-mediated signaling pathway (GO:0060333)2.70660939
94T cell proliferation (GO:0042098)2.70095060
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.69392761
96alpha-beta T cell differentiation (GO:0046632)2.67718847
97positive regulation of tolerance induction (GO:0002645)2.67689421
98negative regulation of interleukin-2 production (GO:0032703)2.67224678
99interferon-gamma production (GO:0032609)2.66577537
100response to laminar fluid shear stress (GO:0034616)2.66479382
101positive regulation of interleukin-12 production (GO:0032735)2.65901777
102neutrophil activation (GO:0042119)2.64819833
103regulation of interleukin-8 biosynthetic process (GO:0045414)2.63891644
104granulocyte activation (GO:0036230)2.62877822
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61696635
106myeloid leukocyte activation (GO:0002274)2.60967039
107T cell lineage commitment (GO:0002360)2.60931839
108type I interferon signaling pathway (GO:0060337)2.60458199
109cellular response to type I interferon (GO:0071357)2.60458199
110monocyte chemotaxis (GO:0002548)2.60066912
111response to type I interferon (GO:0034340)2.59167751
112positive regulation of isotype switching (GO:0045830)2.58820736
113mast cell activation (GO:0045576)2.58795301
114positive regulation of cytokine biosynthetic process (GO:0042108)2.57254107
115positive regulation of immunoglobulin mediated immune response (GO:0002891)2.56844158
116positive regulation of B cell mediated immunity (GO:0002714)2.56844158
117immunoglobulin mediated immune response (GO:0016064)2.55181034
118regulation of alpha-beta T cell proliferation (GO:0046640)2.54778403
119antigen processing and presentation of endogenous antigen (GO:0019883)2.54681198
120dendritic cell differentiation (GO:0097028)2.54477821
121positive regulation of metanephros development (GO:0072216)2.54373584
122negative regulation of T cell differentiation in thymus (GO:0033085)2.53299190
123germinal center formation (GO:0002467)2.53272268
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52273684
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50135431
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50135431
127regulation of podosome assembly (GO:0071801)2.49889392
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.49329028
129negative regulation of interleukin-12 production (GO:0032695)2.49180255
130regulation of vitamin D biosynthetic process (GO:0060556)2.49107646
131positive regulation of T cell differentiation in thymus (GO:0033089)2.48028135
132positive regulation of type 2 immune response (GO:0002830)2.47622325
133negative regulation of cell killing (GO:0031342)2.47506038
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47506038
135* cellular response to gonadotropin stimulus (GO:0071371)2.47300957
136negative regulation of lipid storage (GO:0010888)2.47052818
137positive regulation of macrophage differentiation (GO:0045651)2.42311255
138heterotypic cell-cell adhesion (GO:0034113)2.42281936
139response to interleukin-15 (GO:0070672)2.41705215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.44756320
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.51312308
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19043502
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.09312882
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.36379375
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.30201170
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.14621615
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13630324
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.94956712
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91093611
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86567050
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.77183031
13RUNX_20019798_ChIP-Seq_JUKART_Human2.75994573
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.61037094
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37913134
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.29300851
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28322973
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.26342168
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20810586
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16861815
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12812005
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07481558
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.03142853
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97160036
25VDR_21846776_ChIP-Seq_THP-1_Human1.91512313
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88567245
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83335203
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83035002
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80315832
30* MYB_26560356_Chip-Seq_TH2_Human1.75457456
31SPI1_23547873_ChIP-Seq_NB4_Human1.66908720
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.65433699
33VDR_24787735_ChIP-Seq_THP-1_Human1.65304406
34* MAF_26560356_Chip-Seq_TH2_Human1.63509330
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60831809
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53248414
37MAF_26560356_Chip-Seq_TH1_Human1.52729989
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50143791
39VDR_24763502_ChIP-Seq_THP-1_Human1.49851836
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48151158
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.47874054
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47607907
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47345819
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.45659331
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42186156
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.39571043
47* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38995280
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36303451
49CJUN_26792858_Chip-Seq_BT549_Human1.34636158
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34159922
51AR_21572438_ChIP-Seq_LNCaP_Human1.33127178
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33029889
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32132821
54* MYB_26560356_Chip-Seq_TH1_Human1.30609355
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30297752
56CLOCK_20551151_ChIP-Seq_293T_Human1.24842127
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.24635241
58* GATA3_26560356_Chip-Seq_TH2_Human1.23167521
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20332567
60* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20315174
61* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20315174
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18831380
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17670732
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17272343
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.15845967
66* PU_27001747_Chip-Seq_BMDM_Mouse1.15429288
67* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15238009
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14906480
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13639906
70TP53_18474530_ChIP-ChIP_U2OS_Human1.12271377
71* KDM2B_26808549_Chip-Seq_DND41_Human1.11973015
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10168719
73UTX_26944678_Chip-Seq_JUKART_Human1.10148589
74SCL_19346495_ChIP-Seq_HPC-7_Human1.09843171
75TP53_16413492_ChIP-PET_HCT116_Human1.09198440
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08305262
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06964783
78GATA3_27048872_Chip-Seq_THYMUS_Human1.06578266
79* WT1_19549856_ChIP-ChIP_CCG9911_Human1.06255600
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04839439
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04305112
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.03756941
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02358457
84AHR_22903824_ChIP-Seq_MCF-7_Human1.01386877
85* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00685703
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00678996
87* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99796726
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97921148
89SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95533208
90GATA1_22025678_ChIP-Seq_K562_Human0.94440519
91CIITA_25753668_ChIP-Seq_RAJI_Human0.94372661
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94365052
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92933650
94* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91811034
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91407959
96TFEB_21752829_ChIP-Seq_HELA_Human0.91096545
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90558731
98* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90301172
99* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90059935
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89496008
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88609445
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88285310
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88152027
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87660023
105SOX2_20726797_ChIP-Seq_SW620_Human0.87443700
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87133471
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86694657
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.86645488
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86186171
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86140589
111* UBF1/2_26484160_Chip-Seq_HMECs_Human0.85760773
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85367811
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85367811
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84645070
115* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83520328
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83304944
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83225911
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82324795
119MYC_22102868_ChIP-Seq_BL_Human0.82277907
120SPI1_23127762_ChIP-Seq_K562_Human0.82216822
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81658176
122RXR_22108803_ChIP-Seq_LS180_Human0.81602295
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81233565
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80970490
125* SMRT_27268052_Chip-Seq_Bcells_Human0.80946661
126KLF5_25053715_ChIP-Seq_YYC3_Human0.80915138
127* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80311335
128NCOR1_26117541_ChIP-Seq_K562_Human0.78837204
129* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75960603
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75825435
131* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74087586
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73485182
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73485182
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73485182
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.73073592
136* KDM2B_26808549_Chip-Seq_K562_Human0.72975691
137LXR_22292898_ChIP-Seq_THP-1_Human0.72920977
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72271224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.42580666
2MP0003436_decreased_susceptibility_to3.40989504
3MP0004510_myositis3.34339488
4MP0003303_peritoneal_inflammation3.21897220
5MP0003724_increased_susceptibility_to3.06429295
6MP0005000_abnormal_immune_tolerance2.83869354
7MP0009840_abnormal_foam_cell2.78396623
8MP0002138_abnormal_hepatobiliary_system2.74322503
9MP0006082_CNS_inflammation2.70591908
10MP0001790_abnormal_immune_system2.66844257
11MP0005387_immune_system_phenotype2.66844257
12MP0003763_abnormal_thymus_physiology2.65805730
13MP0002148_abnormal_hypersensitivity_rea2.63546108
14MP0002419_abnormal_innate_immunity2.55703269
15MP0002405_respiratory_system_inflammati2.48904587
16MP0004947_skin_inflammation2.47849889
17MP0000685_abnormal_immune_system2.47203954
18MP0001853_heart_inflammation2.41661502
19MP0002452_abnormal_antigen_presenting2.40115752
20MP0002254_reproductive_system_inflammat2.38657161
21MP0001851_eye_inflammation2.36945750
22MP0003300_gastrointestinal_ulcer2.35126538
23MP0001800_abnormal_humoral_immune2.30589959
24MP0002723_abnormal_immune_serum2.28747516
25MP0005671_abnormal_response_to2.22972094
26MP0002009_preneoplasia2.09829069
27MP0009785_altered_susceptibility_to2.07563460
28MP0002420_abnormal_adaptive_immunity2.04594354
29MP0001819_abnormal_immune_cell2.02202487
30MP0005025_abnormal_response_to2.01688459
31MP0001533_abnormal_skeleton_physiology1.97767991
32MP0002166_altered_tumor_susceptibility1.97764765
33MP0004381_abnormal_hair_follicle1.93308727
34MP0002998_abnormal_bone_remodeling1.91705504
35MP0002006_tumorigenesis1.88046333
36MP0002933_joint_inflammation1.75642894
37MP0003690_abnormal_glial_cell1.65673162
38MP0010155_abnormal_intestine_physiology1.64012797
39MP0003453_abnormal_keratinocyte_physiol1.62837712
40MP0004883_abnormal_blood_vessel1.57559146
41MP0003828_pulmonary_edema1.52603098
42MP0009278_abnormal_bone_marrow1.52490628
43MP0008438_abnormal_cutaneous_collagen1.52259262
44MP0001845_abnormal_inflammatory_respons1.49145954
45MP0003448_altered_tumor_morphology1.48536417
46MP0000716_abnormal_immune_system1.43404678
47MP0003075_altered_response_to1.40990937
48MP0005390_skeleton_phenotype1.40742071
49MP0004808_abnormal_hematopoietic_stem1.36663684
50MP0002398_abnormal_bone_marrow1.34788987
51MP0002060_abnormal_skin_morphology1.34317296
52MP0005423_abnormal_somatic_nervous1.33915141
53MP0005275_abnormal_skin_tensile1.33392999
54MP0005164_abnormal_response_to1.33218432
55MP0005076_abnormal_cell_differentiation1.31654334
56MP0002139_abnormal_hepatobiliary_system1.31155064
57MP0005464_abnormal_platelet_physiology1.27501009
58MP0005023_abnormal_wound_healing1.24501869
59MP0005166_decreased_susceptibility_to1.23317279
60MP0009333_abnormal_splenocyte_physiolog1.20350492
61MP0001873_stomach_inflammation1.20126528
62MP0005310_abnormal_salivary_gland1.19794417
63MP0003866_abnormal_defecation1.18122388
64MP0005451_abnormal_body_composition1.17440836
65MP0001243_abnormal_dermal_layer1.15464368
66MP0000689_abnormal_spleen_morphology1.15382052
67MP0008004_abnormal_stomach_pH1.12637073
68MP0001727_abnormal_embryo_implantation1.12136611
69MP0000383_abnormal_hair_follicle1.11504610
70MP0005058_abnormal_lysosome_morphology1.11111232
71MP0002722_abnormal_immune_system1.07367495
72MP0003091_abnormal_cell_migration1.05788558
73* MP0003795_abnormal_bone_structure1.05211443
74MP0001216_abnormal_epidermal_layer1.04603325
75MP0000703_abnormal_thymus_morphology1.04564167
76MP0000465_gastrointestinal_hemorrhage1.03817345
77MP0003045_fibrosis1.03767631
78MP0002429_abnormal_blood_cell1.03010694
79MP0003566_abnormal_cell_adhesion1.01653659
80MP0000604_amyloidosis0.91196002
81MP0002277_abnormal_respiratory_mucosa0.90921434
82MP0008961_abnormal_basal_metabolism0.90397469
83MP0008469_abnormal_protein_level0.89825003
84MP0000858_altered_metastatic_potential0.86366365
85* MP0000920_abnormal_myelination0.86076482
86MP0002396_abnormal_hematopoietic_system0.85477803
87MP0010307_abnormal_tumor_latency0.85408381
88* MP0004742_abnormal_vestibular_system0.84974075
89MP0009764_decreased_sensitivity_to0.84680854
90MP0003172_abnormal_lysosome_physiology0.84306740
91MP0000343_altered_response_to0.83943230
92MP0005397_hematopoietic_system_phenotyp0.83936795
93MP0001545_abnormal_hematopoietic_system0.83936795
94MP0003279_aneurysm0.83734188
95MP0005257_abnormal_intraocular_pressure0.83334394
96MP0000249_abnormal_blood_vessel0.80147808
97MP0005508_abnormal_skeleton_morphology0.78047374
98MP0005647_abnormal_sex_gland0.77676658
99MP0001346_abnormal_lacrimal_gland0.76964654
100MP0005167_abnormal_blood-brain_barrier0.76598543
101MP0003191_abnormal_cellular_cholesterol0.75470001
102MP0001501_abnormal_sleep_pattern0.75083584
103MP0003656_abnormal_erythrocyte_physiolo0.74081939
104MP0001191_abnormal_skin_condition0.72866522
105MP0010678_abnormal_skin_adnexa0.71858383
106MP0003329_amyloid_beta_deposits0.71203647
107MP0002090_abnormal_vision0.71124220
108MP0000371_diluted_coat_color0.69798850
109MP0009115_abnormal_fat_cell0.69221720
110MP0001663_abnormal_digestive_system0.68878357
111MP0002693_abnormal_pancreas_physiology0.66856279
112MP0009765_abnormal_xenobiotic_induced0.65297334
113MP0005171_absent_coat_pigmentation0.64562906
114MP0000733_abnormal_muscle_development0.63872054
115MP0002098_abnormal_vibrissa_morphology0.62513429
116MP0000767_abnormal_smooth_muscle0.62371878
117MP0009763_increased_sensitivity_to0.61500107
118MP0000609_abnormal_liver_physiology0.61343350
119MP0001348_abnormal_lacrimal_gland0.60614466
120MP0008057_abnormal_DNA_replication0.58016712
121MP0008260_abnormal_autophagy0.56671411
122MP0008995_early_reproductive_senescence0.54061523
123MP0002877_abnormal_melanocyte_morpholog0.51662884

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.60306737
2Stomatitis (HP:0010280)5.80754162
3Recurrent abscess formation (HP:0002722)4.52722016
4Prostate neoplasm (HP:0100787)4.05261524
5Mediastinal lymphadenopathy (HP:0100721)4.04957336
6Elevated erythrocyte sedimentation rate (HP:0003565)3.90186055
7Recurrent bacterial skin infections (HP:0005406)3.89603941
8Gastrointestinal stroma tumor (HP:0100723)3.59029668
9Recurrent fungal infections (HP:0002841)3.58787130
10Recurrent gram-negative bacterial infections (HP:0005420)3.46721464
11Recurrent sinusitis (HP:0011108)3.33018017
12Stomach cancer (HP:0012126)3.31424488
13Gingivitis (HP:0000230)3.30546466
14Thick nail (HP:0001805)3.08033263
15Abnormality of macrophages (HP:0004311)3.06785790
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.04541406
17Loss of speech (HP:0002371)2.95804507
18Restrictive lung disease (HP:0002091)2.95345418
19Myocardial infarction (HP:0001658)2.92729285
20Pustule (HP:0200039)2.91629123
21Increased IgM level (HP:0003496)2.88887865
22Recurrent bronchitis (HP:0002837)2.85510560
23Obstructive lung disease (HP:0006536)2.84016222
24Chronic obstructive pulmonary disease (HP:0006510)2.84016222
25Recurrent skin infections (HP:0001581)2.82565878
26Axonal loss (HP:0003447)2.79031341
27IgG deficiency (HP:0004315)2.77446857
28* Segmental peripheral demyelination/remyelination (HP:0003481)2.74621558
29Recurrent cutaneous fungal infections (HP:0011370)2.70052846
30Chronic mucocutaneous candidiasis (HP:0002728)2.70052846
31Lymphopenia (HP:0001888)2.69950757
32Osteolytic defects of the hand bones (HP:0009699)2.69948350
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.69948350
34Parakeratosis (HP:0001036)2.62905364
35Vacuolated lymphocytes (HP:0001922)2.60453092
36Orchitis (HP:0100796)2.59830713
37Persistence of primary teeth (HP:0006335)2.59811216
38Mutism (HP:0002300)2.58291058
39Retrobulbar optic neuritis (HP:0100654)2.57419426
40Optic neuritis (HP:0100653)2.57419426
41Myositis (HP:0100614)2.54590258
42Neuronal loss in central nervous system (HP:0002529)2.50369581
43Abnormality of T cell number (HP:0011839)2.49103742
44Panhypogammaglobulinemia (HP:0003139)2.48017810
45Systemic lupus erythematosus (HP:0002725)2.46774183
46T lymphocytopenia (HP:0005403)2.46687682
47Abnormality of the nasal septum (HP:0000419)2.46376721
48Vasculitis (HP:0002633)2.46095737
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.45160541
50Increased IgE level (HP:0003212)2.44774869
51Autoimmune hemolytic anemia (HP:0001890)2.43703200
52Cheilitis (HP:0100825)2.38931114
53Chronic diarrhea (HP:0002028)2.38257012
54Increased cerebral lipofuscin (HP:0011813)2.37153006
55Arterial tortuosity (HP:0005116)2.33759738
56Alveolar cell carcinoma (HP:0006519)2.31314111
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31221652
58Abnormality of polysaccharide metabolism (HP:0011012)2.31221652
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31221652
60Abnormality of the prostate (HP:0008775)2.31046635
61Leukocytosis (HP:0001974)2.30143861
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28567123
63Disinhibition (HP:0000734)2.25380584
64Abnormality of T cell physiology (HP:0011840)2.25163929
65Lip pit (HP:0100267)2.25130826
66Cellulitis (HP:0100658)2.23640470
67Pulmonary infiltrates (HP:0002113)2.23491042
68Submucous cleft hard palate (HP:0000176)2.23083574
69Vascular tortuosity (HP:0004948)2.22142769
70Apathy (HP:0000741)2.20447511
71Abnormality of liposaccharide metabolism (HP:0010968)2.20412559
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.20412559
73Abnormality of glycolipid metabolism (HP:0010969)2.20412559
74Neoplasm of the tracheobronchial system (HP:0100552)2.18620314
75Periodontitis (HP:0000704)2.17983078
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.17672712
77Interstitial pulmonary disease (HP:0006530)2.13838731
78Joint swelling (HP:0001386)2.12242208
79Diminished motivation (HP:0000745)2.11081656
80Chronic otitis media (HP:0000389)2.10186505
81Alopecia of scalp (HP:0002293)2.09804022
82Recurrent viral infections (HP:0004429)2.09317462
83Urinary glycosaminoglycan excretion (HP:0003541)2.08752535
84Mucopolysacchariduria (HP:0008155)2.08752535
85Cerebral aneurysm (HP:0004944)2.06124298
86Arthralgia (HP:0002829)2.04910810
87Hypergammaglobulinemia (HP:0010702)2.04329641
88Encephalitis (HP:0002383)2.03311359
89Spondylolisthesis (HP:0003302)2.03178061
90Metaphyseal irregularity (HP:0003025)2.03062081
91Keratoconjunctivitis sicca (HP:0001097)2.02109453
92Eosinophilia (HP:0001880)2.01756276
93Agammaglobulinemia (HP:0004432)2.01621927
94Flat occiput (HP:0005469)2.00228446
95Hemoptysis (HP:0002105)1.99214723
96Thin bony cortex (HP:0002753)1.98597229
97Gastrointestinal infarctions (HP:0005244)1.97989019
98Dysostosis multiplex (HP:0000943)1.97527270
99Disproportionate tall stature (HP:0001519)1.97467384
100Urethral obstruction (HP:0000796)1.97399197
101Combined immunodeficiency (HP:0005387)1.97266331
102Fatigue (HP:0012378)1.96937563
103Tetraparesis (HP:0002273)1.96465673
104Spontaneous hematomas (HP:0007420)1.96293308
105Thoracic kyphosis (HP:0002942)1.95967812
106Slow saccadic eye movements (HP:0000514)1.95562961
107Amaurosis fugax (HP:0100576)1.95048686
108Premature loss of primary teeth (HP:0006323)1.94747943
109Glomerulonephritis (HP:0000099)1.94143018
110Obstructive sleep apnea (HP:0002870)1.93753551
111Hepatosplenomegaly (HP:0001433)1.93532814
112Autoimmune thrombocytopenia (HP:0001973)1.93081699
113Severe combined immunodeficiency (HP:0004430)1.92425769
114* Ulnar claw (HP:0001178)1.92127109
115Hematochezia (HP:0002573)1.90287637
116Verrucae (HP:0200043)1.89099985
117Papilloma (HP:0012740)1.89099985
118Aortic aneurysm (HP:0004942)1.88444484
119Aortic dissection (HP:0002647)1.86381010
120Abnormality of T cells (HP:0002843)1.86002966
121Gingival bleeding (HP:0000225)1.85706657
122Aplasia cutis congenita (HP:0001057)1.81683180
123Mitral valve prolapse (HP:0001634)1.80272563
124Pulmonary artery stenosis (HP:0004415)1.78987110
125Inflammation of the large intestine (HP:0002037)1.78710485
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77175867
127Premature rupture of membranes (HP:0001788)1.76729210
128Depressed nasal tip (HP:0000437)1.76507936
129IgA deficiency (HP:0002720)1.75287313
130Osteomyelitis (HP:0002754)1.74099334
131Increased density of long bones (HP:0006392)1.74048707
132Peritonitis (HP:0002586)1.72902017
133Ectropion (HP:0000656)1.71850112
134Somatic mutation (HP:0001428)1.71156922
135Recurrent pneumonia (HP:0006532)1.70746783
136Abnormality of eosinophils (HP:0001879)1.70426749
137Meningitis (HP:0001287)1.69670466
138IgM deficiency (HP:0002850)1.69351050
139Skin ulcer (HP:0200042)1.69241833
140Dilatation of the ascending aorta (HP:0005111)1.68478437
141Abnormality of male internal genitalia (HP:0000022)1.67845328
142Emphysema (HP:0002097)1.67126880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.40519287
2MAP3K143.59343682
3TXK3.58470872
4PASK2.89170656
5TGFBR22.75321034
6IKBKB2.61805049
7EPHB12.49203412
8PIM22.34305454
9RIPK42.31058895
10MAPK152.22987340
11STK102.08140682
12IKBKE2.01772484
13TBK11.98523274
14CHUK1.93463574
15ITK1.89818567
16JAK31.89585612
17EPHA31.89470954
18MAP3K31.86340713
19IRAK41.80009307
20ZAP701.76661401
21TYK21.69743816
22NLK1.64703780
23BMPR21.62826482
24GRK71.61508041
25TAOK31.48381964
26FGFR41.42806140
27CAMKK21.36679958
28MST41.34948349
29FGFR31.31967112
30TRPM71.31426293
31RPS6KA51.31313222
32RPS6KA41.30999882
33CAMKK11.30855893
34BLK1.30783648
35CSK1.29322139
36PBK1.27323715
37SIK21.27223024
38TEC1.27112183
39HCK1.25430734
40BRD41.24194392
41IRAK11.17590839
42LCK1.16883928
43JAK11.13874581
44MAP2K31.10977884
45MAP3K111.08872480
46PIM11.08263433
47IRAK31.07770834
48BMPR1B1.04284311
49PDGFRB1.02615355
50CDK121.02302481
51DMPK1.02105487
52MAP3K101.00067979
53JAK20.98815803
54SIK10.97930603
55MAPK70.96528503
56RIPK10.95898528
57TYRO30.94189723
58DDR20.93956849
59STK240.93716842
60MAP2K20.93517322
61CLK10.91857808
62CDC42BPA0.89924688
63HIPK20.89324165
64MAPK120.89182538
65NEK90.88565951
66PRPF4B0.87458912
67MATK0.84735127
68MAPKAPK20.83403956
69SMG10.82155735
70MAPKAPK50.82109257
71TAOK10.79962387
72GSK3A0.79094634
73PRKCQ0.75087299
74CDK90.75032482
75RPS6KC10.74840571
76RPS6KL10.74840571
77SYK0.73478054
78RPS6KA10.72996221
79NEK60.72703246
80MARK30.71944770
81BTK0.69646472
82ERBB30.69142522
83MAP3K130.69081472
84KIT0.68025247
85MOS0.65236886
86SIK30.64178232
87MAP3K10.64131701
88BMX0.63985175
89NUAK10.63136483
90MAP3K50.62754230
91LYN0.62583069
92TNK20.61156349
93RPS6KA20.59140250
94PRKCH0.58402683
95CAMK40.57818045
96IRAK20.57690423
97MAP3K20.57412687
98INSR0.57370900
99CDK60.55947545
100MELK0.55586078
101FGR0.53197138
102TRIM280.52856718
103ABL10.51221555
104RAF10.49806212
105CAMK1D0.46995705
106RPS6KA60.45536720
107YES10.45251330
108EIF2AK30.45203826
109PDK10.45076687
110ERN10.44111929
111TAOK20.43807595
112EGFR0.42399473
113CSF1R0.40570911
114MARK20.40541575
115FES0.38724640
116CAMK1G0.38291840
117SGK20.36817507
118ADRBK20.36763603
119MAPK10.36319478
120MAPK30.33502766
121TGFBR10.33177109
122PAK20.31131316
123SGK30.30132404
124PDK20.27352894
125FYN0.27211900
126PRKCD0.26864188
127ROCK20.26816200
128MAPK40.26694562

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.72323079
2Osteoclast differentiation_Homo sapiens_hsa043802.68206057
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.62332940
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.50855048
5Graft-versus-host disease_Homo sapiens_hsa053322.50311549
6Allograft rejection_Homo sapiens_hsa053302.37804799
7T cell receptor signaling pathway_Homo sapiens_hsa046602.18706245
8Asthma_Homo sapiens_hsa053102.00340052
9Malaria_Homo sapiens_hsa051441.99946111
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97890588
11TNF signaling pathway_Homo sapiens_hsa046681.85525900
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83873019
13Rheumatoid arthritis_Homo sapiens_hsa053231.82418072
14Measles_Homo sapiens_hsa051621.76268930
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.74081780
16Toxoplasmosis_Homo sapiens_hsa051451.73179860
17Legionellosis_Homo sapiens_hsa051341.72522799
18Pertussis_Homo sapiens_hsa051331.72173469
19B cell receptor signaling pathway_Homo sapiens_hsa046621.69213114
20Primary immunodeficiency_Homo sapiens_hsa053401.68942089
21Staphylococcus aureus infection_Homo sapiens_hsa051501.68535536
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64702764
23Tuberculosis_Homo sapiens_hsa051521.59069273
24Autoimmune thyroid disease_Homo sapiens_hsa053201.55994199
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.55213042
26Hematopoietic cell lineage_Homo sapiens_hsa046401.48715419
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48685191
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44229723
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42685353
30Salmonella infection_Homo sapiens_hsa051321.42076306
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33020053
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31514943
33African trypanosomiasis_Homo sapiens_hsa051431.29060240
34Apoptosis_Homo sapiens_hsa042101.25979159
35Influenza A_Homo sapiens_hsa051641.25296497
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23375253
37* Hepatitis B_Homo sapiens_hsa051611.21584047
38Acute myeloid leukemia_Homo sapiens_hsa052211.21357599
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.20168808
40Type I diabetes mellitus_Homo sapiens_hsa049401.19218815
41Chemokine signaling pathway_Homo sapiens_hsa040621.18354274
42Phagosome_Homo sapiens_hsa041451.13042722
43Lysosome_Homo sapiens_hsa041421.09731407
44Shigellosis_Homo sapiens_hsa051311.08933542
45Prolactin signaling pathway_Homo sapiens_hsa049171.08849373
46Herpes simplex infection_Homo sapiens_hsa051681.08144307
47Chronic myeloid leukemia_Homo sapiens_hsa052201.07710195
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06495699
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06014534
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.05022367
51Prion diseases_Homo sapiens_hsa050201.04528976
52Viral myocarditis_Homo sapiens_hsa054161.00405996
53Hepatitis C_Homo sapiens_hsa051600.98286359
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95928959
55Amoebiasis_Homo sapiens_hsa051460.94429849
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92719368
57Antigen processing and presentation_Homo sapiens_hsa046120.88751820
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88613499
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87693440
60MAPK signaling pathway_Homo sapiens_hsa040100.84832755
61Pancreatic cancer_Homo sapiens_hsa052120.80296757
62* HTLV-I infection_Homo sapiens_hsa051660.78400834
63Platelet activation_Homo sapiens_hsa046110.76273850
64Other glycan degradation_Homo sapiens_hsa005110.75058031
65Small cell lung cancer_Homo sapiens_hsa052220.71925979
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69715219
67TGF-beta signaling pathway_Homo sapiens_hsa043500.68657826
68Circadian rhythm_Homo sapiens_hsa047100.68560274
69Prostate cancer_Homo sapiens_hsa052150.68224152
70ECM-receptor interaction_Homo sapiens_hsa045120.66534701
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65295180
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.63517066
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.63028695
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62885692
75Adherens junction_Homo sapiens_hsa045200.62649328
76HIF-1 signaling pathway_Homo sapiens_hsa040660.62192502
77Dorso-ventral axis formation_Homo sapiens_hsa043200.61490069
78Notch signaling pathway_Homo sapiens_hsa043300.60961171
79Proteoglycans in cancer_Homo sapiens_hsa052050.60341427
80MicroRNAs in cancer_Homo sapiens_hsa052060.58065562
81mTOR signaling pathway_Homo sapiens_hsa041500.56968779
82Colorectal cancer_Homo sapiens_hsa052100.56553355
83FoxO signaling pathway_Homo sapiens_hsa040680.56059885
84Renal cell carcinoma_Homo sapiens_hsa052110.54020506
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53736098
86VEGF signaling pathway_Homo sapiens_hsa043700.53506279
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.53442151
88Focal adhesion_Homo sapiens_hsa045100.52403222
89Type II diabetes mellitus_Homo sapiens_hsa049300.50109438
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48533503
91Non-small cell lung cancer_Homo sapiens_hsa052230.46106164
92Pathways in cancer_Homo sapiens_hsa052000.43116686
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42935543
94Endometrial cancer_Homo sapiens_hsa052130.41777834
95* Viral carcinogenesis_Homo sapiens_hsa052030.41580480
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40000405
97GnRH signaling pathway_Homo sapiens_hsa049120.39050124
98Endocytosis_Homo sapiens_hsa041440.37530556
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37421113
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37237487
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36971801
102Steroid biosynthesis_Homo sapiens_hsa001000.36792868
103Sphingolipid metabolism_Homo sapiens_hsa006000.36491125
104ErbB signaling pathway_Homo sapiens_hsa040120.36189814
105Collecting duct acid secretion_Homo sapiens_hsa049660.35937540
106Rap1 signaling pathway_Homo sapiens_hsa040150.35384297
107Ras signaling pathway_Homo sapiens_hsa040140.34303239
108Choline metabolism in cancer_Homo sapiens_hsa052310.34084113
109Epstein-Barr virus infection_Homo sapiens_hsa051690.33284050
110Insulin resistance_Homo sapiens_hsa049310.32705394
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.28526027
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28243068
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27631192
114Estrogen signaling pathway_Homo sapiens_hsa049150.25848842
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25207559
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25091719
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24662761
118Inositol phosphate metabolism_Homo sapiens_hsa005620.23959497

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