EGR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* endothelial cell chemotaxis (GO:0035767)8.69531022
2positive thymic T cell selection (GO:0045059)6.21615221
3positive T cell selection (GO:0043368)5.63383544
4thymic T cell selection (GO:0045061)5.60306381
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.14419954
6regulation of interleukin-12 biosynthetic process (GO:0045075)5.09657346
7T cell selection (GO:0045058)5.08375860
8negative thymic T cell selection (GO:0045060)5.01885674
9negative T cell selection (GO:0043383)4.87511671
10negative regulation of T cell differentiation in thymus (GO:0033085)4.74336249
11regulation of regulatory T cell differentiation (GO:0045589)4.70839505
12positive regulation of gamma-delta T cell activation (GO:0046645)4.70693267
13NIK/NF-kappaB signaling (GO:0038061)4.60147162
14* cell migration involved in sprouting angiogenesis (GO:0002042)4.51775716
15response to interleukin-15 (GO:0070672)4.44869729
16regulation of immunoglobulin secretion (GO:0051023)4.23642251
17* regulation of gamma-delta T cell differentiation (GO:0045586)4.08763417
18interferon-gamma production (GO:0032609)4.02823814
19response to isoquinoline alkaloid (GO:0014072)4.01873183
20positive regulation of T cell apoptotic process (GO:0070234)3.90257536
21regulation of isotype switching to IgG isotypes (GO:0048302)3.86947770
22regulation of T cell tolerance induction (GO:0002664)3.75556998
23cellular response to interleukin-15 (GO:0071350)3.71756828
24regulation of neuronal synaptic plasticity (GO:0048168)3.70440212
25T cell receptor signaling pathway (GO:0050852)3.63641886
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62941641
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.59096174
28synaptic vesicle maturation (GO:0016188)3.58600422
29negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.54761814
30positive regulation of interleukin-2 production (GO:0032743)3.54700216
31* regulation of gamma-delta T cell activation (GO:0046643)3.54061326
32locomotory exploration behavior (GO:0035641)3.41986941
33* cellular response to gonadotropin stimulus (GO:0071371)3.40665039
34mast cell degranulation (GO:0043303)3.39881576
35mast cell activation involved in immune response (GO:0002279)3.39881576
36regulation of thymocyte apoptotic process (GO:0070243)3.39050697
37negative regulation of cell killing (GO:0031342)3.31191890
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31191890
39regulation of interleukin-2 biosynthetic process (GO:0045076)3.29432815
40skeletal muscle cell differentiation (GO:0035914)3.28678453
41regulation of p38MAPK cascade (GO:1900744)3.28045039
42negative regulation of inclusion body assembly (GO:0090084)3.24544345
43myeloid dendritic cell differentiation (GO:0043011)3.23978807
44response to morphine (GO:0043278)3.21478193
45lung lobe morphogenesis (GO:0060463)3.21286175
46* blood vessel endothelial cell migration (GO:0043534)3.21027245
47tyrosine phosphorylation of STAT protein (GO:0007260)3.20726976
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20519199
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.19741106
50activation of MAPKKK activity (GO:0000185)3.15705493
51RNA destabilization (GO:0050779)3.13052899
52negative regulation of erythrocyte differentiation (GO:0045647)3.12431971
53germinal center formation (GO:0002467)3.10813282
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10517519
55positive regulation of astrocyte differentiation (GO:0048711)3.10372498
56mast cell activation (GO:0045576)3.07585863
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.06215581
58regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.03004543
59positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.03004543
60positive regulation of tolerance induction (GO:0002645)3.02046735
61T cell costimulation (GO:0031295)3.01590984
62atrioventricular valve morphogenesis (GO:0003181)3.01383875
63oxygen transport (GO:0015671)3.00927944
64positive regulation of metanephros development (GO:0072216)2.99957027
65leukocyte aggregation (GO:0070486)2.97181135
66positive regulation of lymphocyte apoptotic process (GO:0070230)2.96300812
67lymphocyte costimulation (GO:0031294)2.95207961
68T cell migration (GO:0072678)2.94033941
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93688298
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93688298
71regulation of interleukin-13 production (GO:0032656)2.92320421
72natural killer cell differentiation (GO:0001779)2.91973272
73positive regulation of isotype switching (GO:0045830)2.86914387
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86731441
75antigen receptor-mediated signaling pathway (GO:0050851)2.86454847
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.80996176
77positive regulation of Rap GTPase activity (GO:0032854)2.80214957
78regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.80085280
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.80085280
80myeloid dendritic cell activation (GO:0001773)2.79469081
81glutamate secretion (GO:0014047)2.78922125
82interleukin-1-mediated signaling pathway (GO:0070498)2.76565076
83positive regulation of endothelial cell apoptotic process (GO:2000353)2.74684481
84regulation of Rap GTPase activity (GO:0032317)2.72617498
85response to muramyl dipeptide (GO:0032495)2.71912798
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.71862249
87* cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.71675899
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69796501
89establishment of skin barrier (GO:0061436)2.68275431
90long-term synaptic potentiation (GO:0060291)2.67333527
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66877361
92positive regulation of p38MAPK cascade (GO:1900745)2.66541759
93regulation of T-helper 2 cell differentiation (GO:0045628)2.65805526
94* response to gonadotropin (GO:0034698)2.65600534
95signal complex assembly (GO:0007172)2.63910548
96regulation of cell proliferation involved in kidney development (GO:1901722)2.63590771
97regulation of ARF protein signal transduction (GO:0032012)2.62484869
98positive regulation of humoral immune response (GO:0002922)2.61747409
99regulation of water loss via skin (GO:0033561)2.61044193
100tolerance induction (GO:0002507)2.60851107
101regulation of glutamate receptor signaling pathway (GO:1900449)2.60562469
102negative regulation of T cell differentiation (GO:0045581)2.60302913
103antigen processing and presentation of endogenous antigen (GO:0019883)2.59430135
104regulation of tolerance induction (GO:0002643)2.57655627
105facial nerve structural organization (GO:0021612)2.57376561
106response to amphetamine (GO:0001975)2.57255629
107regulation of synaptic plasticity (GO:0048167)2.56997967
108alpha-beta T cell differentiation (GO:0046632)2.56499181
109cranial nerve structural organization (GO:0021604)2.56179946
110regulation of alpha-beta T cell proliferation (GO:0046640)2.53596019
111steroid hormone mediated signaling pathway (GO:0043401)2.53362665
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51939635
113T cell differentiation (GO:0030217)2.49523338
114regulation of NFAT protein import into nucleus (GO:0051532)2.49403461
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49192843
116vocalization behavior (GO:0071625)2.48945676
117regulation of synaptic vesicle exocytosis (GO:2000300)2.48554138
118synaptic vesicle exocytosis (GO:0016079)2.47796612
119sodium ion export (GO:0071436)2.47743548
120positive regulation of mRNA catabolic process (GO:0061014)2.46620248
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46373266
122negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44721929
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.44318990
124T-helper cell differentiation (GO:0042093)2.44318990
125cellular response to epinephrine stimulus (GO:0071872)2.41397254
126histone H3-K36 demethylation (GO:0070544)2.41374173
127fusion of sperm to egg plasma membrane (GO:0007342)2.38543074
128keratinization (GO:0031424)2.38025922
129regulation of transforming growth factor beta1 production (GO:0032908)2.36125416
130epithelial cell fate commitment (GO:0072148)2.32328033
131cardiac muscle adaptation (GO:0014887)2.28207576
132cardiac muscle hypertrophy in response to stress (GO:0014898)2.28207576
133muscle hypertrophy in response to stress (GO:0003299)2.28207576
134histone demethylation (GO:0016577)2.27271442
135chemosensory behavior (GO:0007635)2.25970527
136L-amino acid import (GO:0043092)2.24856183
137regulation of mRNA catabolic process (GO:0061013)2.23423156
138histone lysine demethylation (GO:0070076)2.23183498
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21407040
140* cellular response to cAMP (GO:0071320)2.19651338
141response to laminar fluid shear stress (GO:0034616)2.19350182
142SMAD protein signal transduction (GO:0060395)2.17511535
143positive regulation of glomerulus development (GO:0090193)2.16789660
144regulation of germinal center formation (GO:0002634)2.14269108
145regulation of somitogenesis (GO:0014807)2.08436057
146regulation of ARF GTPase activity (GO:0032312)2.07481964
147CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.07385675
148response to corticosterone (GO:0051412)2.06562298
149response to epinephrine (GO:0071871)2.06231377
150regulation of histone H3-K27 methylation (GO:0061085)2.04553425
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.02717032
152macrophage activation involved in immune response (GO:0002281)2.00805225
153T cell differentiation involved in immune response (GO:0002292)2.00638680
154alpha-beta T cell differentiation involved in immune response (GO:0002293)2.00638680
155alpha-beta T cell activation involved in immune response (GO:0002287)2.00638680
156response to monoamine (GO:0071867)1.99321694
157response to catecholamine (GO:0071869)1.99321694
158cellular response to antibiotic (GO:0071236)1.99229062
159cellular extravasation (GO:0045123)1.99209959
160sexual reproduction (GO:0019953)1.98214817
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.98058588
162regulation of interleukin-4 production (GO:0032673)1.97635957
163cellular response to toxic substance (GO:0097237)1.96535864
164regulation of female gonad development (GO:2000194)1.96436231
165cAMP catabolic process (GO:0006198)1.96054487
166long-term memory (GO:0007616)1.95767529
167positive regulation of CREB transcription factor activity (GO:0032793)1.95709304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.06875488
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.32030373
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.93211145
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67385664
5MYC_22102868_ChIP-Seq_BL_Human3.55275271
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human3.14816404
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07847807
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.04387992
9RUNX_20019798_ChIP-Seq_JUKART_Human2.87901841
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79673944
11KDM2B_26808549_Chip-Seq_DND41_Human2.73060724
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.63592286
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.59200376
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.47653694
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37621763
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.36835150
17* KDM2B_26808549_Chip-Seq_JURKAT_Human2.20027660
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18747272
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15658087
20MAF_26560356_Chip-Seq_TH1_Human2.09525575
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06850579
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90414680
23UTX_26944678_Chip-Seq_JUKART_Human1.87255699
24* MYB_26560356_Chip-Seq_TH2_Human1.85717629
25* KDM2B_26808549_Chip-Seq_K562_Human1.85064234
26* NOTCH1_21737748_ChIP-Seq_TLL_Human1.83535624
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73219291
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.71583513
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71430494
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64962162
31* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64436750
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.64354770
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.63291716
34MYB_26560356_Chip-Seq_TH1_Human1.62123506
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59977551
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59841554
37VDR_21846776_ChIP-Seq_THP-1_Human1.59306934
38DROSHA_22980978_ChIP-Seq_HELA_Human1.48050217
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47058202
40* EZH2_27304074_Chip-Seq_ESCs_Mouse1.45843669
41VDR_24763502_ChIP-Seq_THP-1_Human1.41810808
42MAF_26560356_Chip-Seq_TH2_Human1.41585628
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.39214474
44* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39208518
45* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38083006
46EGR1_19032775_ChIP-ChIP_M12_Human1.34845069
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33857608
48AR_21572438_ChIP-Seq_LNCaP_Human1.33046632
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32994610
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31935040
51* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31191883
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30759707
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30044108
54* LXR_22292898_ChIP-Seq_THP-1_Human1.29961176
55CLOCK_20551151_ChIP-Seq_293T_Human1.29071503
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27942284
57* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25317751
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23822650
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.23248594
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.22801781
61VDR_24787735_ChIP-Seq_THP-1_Human1.21974730
62* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21891486
63EZH2_22144423_ChIP-Seq_EOC_Human1.21802851
64GATA3_27048872_Chip-Seq_THYMUS_Human1.20864847
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.18682172
66* CREB1_26743006_Chip-Seq_LNCaP_Human1.18598932
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16096925
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15837981
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15467422
70AHR_22903824_ChIP-Seq_MCF-7_Human1.13332982
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11632198
72* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11577347
73* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11577347
74* RNF2_27304074_Chip-Seq_ESCs_Mouse1.10075908
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08636679
76* RUNX1_22412390_ChIP-Seq_EML_Mouse1.08498759
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08198345
78SPI1_23127762_ChIP-Seq_K562_Human1.06881760
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06387608
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06227931
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04320186
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04320186
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04253186
84* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04191947
85* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02885612
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.02683216
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02655502
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02348289
89* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01850083
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01177715
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00899020
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00704879
93* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99863333
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.99342420
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98596253
96* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98079273
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97908087
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96642009
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96440716
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.96170253
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96080637
102* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95437682
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95404121
104* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94863360
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93446542
106REST_18959480_ChIP-ChIP_MESCs_Mouse0.93207985
107SCL_19346495_ChIP-Seq_HPC-7_Human0.92531799
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92497807
109CTCF_27219007_Chip-Seq_Bcells_Human0.92048574
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91848343
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91764521
112* EED_16625203_ChIP-ChIP_MESCs_Mouse0.91492257
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.90552138
114RXR_22108803_ChIP-Seq_LS180_Human0.90074272
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.89932872
116REST_21632747_ChIP-Seq_MESCs_Mouse0.89649116
117GATA1_19941826_ChIP-Seq_K562_Human0.89378328
118* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88610290
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.88562733
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.87697282
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87403024
122* NCOR1_26117541_ChIP-Seq_K562_Human0.87237878
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86838537
124* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86546192
125* EZH2_27294783_Chip-Seq_ESCs_Mouse0.86200981
126* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85972396
127* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85869005
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85445465
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83403874
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80603222
131* TP53_20018659_ChIP-ChIP_R1E_Mouse0.78053426
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.76770241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis4.89363634
2MP0003763_abnormal_thymus_physiology4.74293906
3MP0004859_abnormal_synaptic_plasticity4.20734829
4MP0000685_abnormal_immune_system3.47684887
5MP0008961_abnormal_basal_metabolism3.29333378
6MP0003300_gastrointestinal_ulcer3.22612726
7MP0004742_abnormal_vestibular_system2.95141798
8MP0003436_decreased_susceptibility_to2.85826921
9MP0004808_abnormal_hematopoietic_stem2.81751086
10MP0002822_catalepsy2.80876550
11MP0003303_peritoneal_inflammation2.73971711
12MP0003329_amyloid_beta_deposits2.54283522
13MP0001853_heart_inflammation2.52879142
14MP0000604_amyloidosis2.45232627
15MP0005387_immune_system_phenotype2.30022472
16MP0001790_abnormal_immune_system2.30022472
17MP0005000_abnormal_immune_tolerance2.24853569
18MP0002138_abnormal_hepatobiliary_system2.19303649
19MP0001800_abnormal_humoral_immune2.10691544
20MP0005377_hearing/vestibular/ear_phenot2.08677660
21MP0003878_abnormal_ear_physiology2.08677660
22MP0003866_abnormal_defecation2.07482964
23MP0005671_abnormal_response_to2.06435965
24MP0001501_abnormal_sleep_pattern2.05514035
25MP0002405_respiratory_system_inflammati2.05293473
26MP0005410_abnormal_fertilization1.98470178
27* MP0003635_abnormal_synaptic_transmissio1.98137957
28MP0003828_pulmonary_edema1.89685719
29MP0004947_skin_inflammation1.89352692
30MP0000703_abnormal_thymus_morphology1.87262622
31MP0008004_abnormal_stomach_pH1.86404998
32MP0002723_abnormal_immune_serum1.85867752
33MP0009745_abnormal_behavioral_response1.85531346
34MP0002398_abnormal_bone_marrow1.85239549
35MP0001835_abnormal_antigen_presentation1.78016361
36MP0002420_abnormal_adaptive_immunity1.76594369
37MP0001819_abnormal_immune_cell1.73734059
38MP0002452_abnormal_antigen_presenting1.73704388
39MP0005310_abnormal_salivary_gland1.63992920
40MP0008569_lethality_at_weaning1.60429768
41MP0001851_eye_inflammation1.59516935
42MP0002063_abnormal_learning/memory/cond1.57650623
43MP0001348_abnormal_lacrimal_gland1.56324706
44MP0000716_abnormal_immune_system1.52537111
45MP0004270_analgesia1.51776641
46MP0010155_abnormal_intestine_physiology1.50794797
47MP0002064_seizures1.50455856
48MP0002796_impaired_skin_barrier1.48693460
49MP0003075_altered_response_to1.48645713
50MP0002009_preneoplasia1.42287878
51MP0005646_abnormal_pituitary_gland1.41208173
52MP0003879_abnormal_hair_cell1.40507170
53MP0005670_abnormal_white_adipose1.39225282
54MP0000689_abnormal_spleen_morphology1.34810890
55MP0002722_abnormal_immune_system1.33180339
56MP0005166_decreased_susceptibility_to1.30047537
57MP0001873_stomach_inflammation1.28429225
58MP0005275_abnormal_skin_tensile1.27771378
59MP0003880_abnormal_central_pattern1.26773453
60MP0001440_abnormal_grooming_behavior1.26747514
61MP0002998_abnormal_bone_remodeling1.26485910
62MP0009840_abnormal_foam_cell1.23574745
63MP0002735_abnormal_chemical_nociception1.21168927
64MP0000465_gastrointestinal_hemorrhage1.17054680
65MP0004811_abnormal_neuron_physiology1.16765340
66MP0003283_abnormal_digestive_organ1.14343855
67MP0002429_abnormal_blood_cell1.11029921
68MP0002419_abnormal_innate_immunity1.11012148
69MP0004885_abnormal_endolymph1.10444321
70MP0002572_abnormal_emotion/affect_behav1.10163193
71MP0005535_abnormal_body_temperature1.08511127
72MP0001533_abnormal_skeleton_physiology1.08036909
73MP0001845_abnormal_inflammatory_respons1.07659650
74MP0005025_abnormal_response_to1.06801575
75MP0009333_abnormal_splenocyte_physiolog1.01538729
76MP0002148_abnormal_hypersensitivity_rea1.01181730
77MP0002166_altered_tumor_susceptibility0.99956825
78MP0001486_abnormal_startle_reflex0.93496693
79* MP0002272_abnormal_nervous_system0.92954429
80MP0008995_early_reproductive_senescence0.92614676
81MP0002396_abnormal_hematopoietic_system0.90321768
82MP0009115_abnormal_fat_cell0.89931045
83MP0001485_abnormal_pinna_reflex0.89217803
84MP0000470_abnormal_stomach_morphology0.87188902
85MP0002254_reproductive_system_inflammat0.86253708
86MP0003690_abnormal_glial_cell0.85700421
87MP0005464_abnormal_platelet_physiology0.85177640
88MP0000750_abnormal_muscle_regeneration0.84807008
89* MP0003633_abnormal_nervous_system0.84710788
90MP0002090_abnormal_vision0.83864534
91MP0000249_abnormal_blood_vessel0.83521767
92MP0003045_fibrosis0.82659073
93MP0000920_abnormal_myelination0.82481723
94MP0002089_abnormal_postnatal_growth/wei0.82375877
95MP0008872_abnormal_physiological_respon0.81503181
96MP0003724_increased_susceptibility_to0.81383331
97MP0005164_abnormal_response_to0.79903454
98MP0001970_abnormal_pain_threshold0.79807693
99MP0008874_decreased_physiological_sensi0.79464264
100MP0006082_CNS_inflammation0.78045441
101MP0003091_abnormal_cell_migration0.77849491
102MP0004858_abnormal_nervous_system0.76457279
103MP0002067_abnormal_sensory_capabilities0.76098939
104MP0002006_tumorigenesis0.75323047
105MP0005448_abnormal_energy_balance0.75249307
106MP0009278_abnormal_bone_marrow0.75036456
107MP0004484_altered_response_of0.74817482
108MP0005076_abnormal_cell_differentiation0.72721204
109MP0010234_abnormal_vibrissa_follicle0.72503719
110MP0002249_abnormal_larynx_morphology0.71234969
111MP0001968_abnormal_touch/_nociception0.70324988
112MP0002896_abnormal_bone_mineralization0.69579806
113MP0005167_abnormal_blood-brain_barrier0.68925884
114MP0003172_abnormal_lysosome_physiology0.66119323
115MP0005390_skeleton_phenotype0.64686522
116MP0003705_abnormal_hypodermis_morpholog0.63869271
117MP0004883_abnormal_blood_vessel0.63335241
118MP0003795_abnormal_bone_structure0.62629092
119MP0002933_joint_inflammation0.62418512
120MP0004381_abnormal_hair_follicle0.62359989
121MP0001727_abnormal_embryo_implantation0.61915592
122MP0009785_altered_susceptibility_to0.61627937
123MP0001502_abnormal_circadian_rhythm0.61561938
124MP0010307_abnormal_tumor_latency0.60594002
125MP0002557_abnormal_social/conspecific_i0.59656106
126MP0003453_abnormal_keratinocyte_physiol0.57948374
127MP0010352_gastrointestinal_tract_polyps0.56983508
128MP0005023_abnormal_wound_healing0.56968619
129* MP0005423_abnormal_somatic_nervous0.54723466
130MP0009780_abnormal_chondrocyte_physiolo0.54082524

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.20570126
2Peripheral hypomyelination (HP:0007182)6.15902212
3Ulnar claw (HP:0001178)4.54464079
4Increased IgM level (HP:0003496)4.27027977
5Upper limb muscle weakness (HP:0003484)4.17272353
6Segmental peripheral demyelination/remyelination (HP:0003481)3.93313621
7Genetic anticipation (HP:0003743)3.68800172
8Elevated erythrocyte sedimentation rate (HP:0003565)3.55838383
9Myokymia (HP:0002411)3.53354012
10Increased density of long bones (HP:0006392)3.46175216
11Impaired proprioception (HP:0010831)3.41503755
12Progressive cerebellar ataxia (HP:0002073)3.26763088
13Increased CSF protein (HP:0002922)3.24179298
14Annular pancreas (HP:0001734)3.18082999
15Persistence of primary teeth (HP:0006335)3.06880788
16Focal motor seizures (HP:0011153)2.97054286
17Eczematoid dermatitis (HP:0000976)2.96577899
18Cerebral aneurysm (HP:0004944)2.92969186
19IgA deficiency (HP:0002720)2.90460658
20Onion bulb formation (HP:0003383)2.89190207
21IgG deficiency (HP:0004315)2.88990241
22Increased IgE level (HP:0003212)2.82281013
23Dysmetric saccades (HP:0000641)2.81631942
24Hypotrichosis (HP:0001006)2.78538899
25Somatic mutation (HP:0001428)2.75742708
26Abnormality of T cells (HP:0002843)2.75432176
27T lymphocytopenia (HP:0005403)2.74296044
28Panhypogammaglobulinemia (HP:0003139)2.72790680
29Chronic otitis media (HP:0000389)2.67110265
30Arterial tortuosity (HP:0005116)2.66789656
31Abnormality of T cell physiology (HP:0011840)2.64126528
32Focal seizures (HP:0007359)2.62297195
33Abnormality of the fingertips (HP:0001211)2.61988952
34Broad face (HP:0000283)2.61561784
35Abnormality of T cell number (HP:0011839)2.61466670
36Abnormality of B cell number (HP:0010975)2.61466104
37B lymphocytopenia (HP:0010976)2.61466104
38Mitral valve prolapse (HP:0001634)2.59054335
39Spinal canal stenosis (HP:0003416)2.59020048
40Nasal polyposis (HP:0100582)2.57675710
41Germ cell neoplasia (HP:0100728)2.57304303
42Gonadal dysgenesis (HP:0000133)2.54302537
43Palmoplantar hyperkeratosis (HP:0000972)2.49535118
44Recurrent fungal infections (HP:0002841)2.47074610
45Severe combined immunodeficiency (HP:0004430)2.46807441
46Obstructive sleep apnea (HP:0002870)2.45663018
47Bronchomalacia (HP:0002780)2.45348487
48Anomalous pulmonary venous return (HP:0010772)2.45210396
49Severe visual impairment (HP:0001141)2.45145241
50Atonic seizures (HP:0010819)2.43873887
51Recurrent bronchitis (HP:0002837)2.42559361
52Abnormality of binocular vision (HP:0011514)2.40182260
53Diplopia (HP:0000651)2.40182260
54IgM deficiency (HP:0002850)2.39279554
55Visual hallucinations (HP:0002367)2.37742986
56Hammertoe (HP:0001765)2.35356390
57Slow saccadic eye movements (HP:0000514)2.33787894
58Vascular tortuosity (HP:0004948)2.32160407
59Aortic aneurysm (HP:0004942)2.30680215
60Striae distensae (HP:0001065)2.27045826
61Hypergammaglobulinemia (HP:0010702)2.26830766
62Palmar hyperkeratosis (HP:0010765)2.24814852
63Abnormality of the nasal mucosa (HP:0000433)2.23435522
64Urinary urgency (HP:0000012)2.23075018
65Testicular neoplasm (HP:0010788)2.22577180
66Supernumerary ribs (HP:0005815)2.17524236
67Deep palmar crease (HP:0006191)2.17254754
68Hepatitis (HP:0012115)2.17038192
69Disproportionate tall stature (HP:0001519)2.16024655
70Clumsiness (HP:0002312)2.15950068
71Dilatation of the ascending aorta (HP:0005111)2.14710116
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.13259205
73Stomach cancer (HP:0012126)2.11845316
74Abnormality of the nasal septum (HP:0000419)2.11824559
75Abnormality of the columella (HP:0009929)2.11719323
76Abnormality of oral frenula (HP:0000190)2.11613037
77Alveolar cell carcinoma (HP:0006519)2.11387574
78Hemiplegia (HP:0002301)2.10566897
79Pointed chin (HP:0000307)2.09648273
80Combined immunodeficiency (HP:0005387)2.09361219
81Abnormality of the pulmonary veins (HP:0011718)2.08288962
82Abnormality of the axillary hair (HP:0100134)2.08282300
83Abnormality of secondary sexual hair (HP:0009888)2.08282300
84Neoplasm of the heart (HP:0100544)2.06172514
85Lower limb amyotrophy (HP:0007210)2.06071290
86Verrucae (HP:0200043)2.04785126
87Papilloma (HP:0012740)2.04785126
88Neoplasm of the tracheobronchial system (HP:0100552)2.04774189
89Stereotypic behavior (HP:0000733)2.04649341
90Stridor (HP:0010307)2.04381486
91Hyperkalemia (HP:0002153)2.01649991
92Impaired vibration sensation in the lower limbs (HP:0002166)2.01178206
93Plantar hyperkeratosis (HP:0007556)1.99226903
94Postural instability (HP:0002172)1.98980877
95Gingivitis (HP:0000230)1.98925148
96Abnormality of nail color (HP:0100643)1.98535299
97Genu recurvatum (HP:0002816)1.98197526
98Sleep apnea (HP:0010535)1.98049038
99Recurrent viral infections (HP:0004429)1.97789674
100Mediastinal lymphadenopathy (HP:0100721)1.97212194
101Impaired smooth pursuit (HP:0007772)1.96625294
102Supernumerary bones of the axial skeleton (HP:0009144)1.95586297
103Epileptic encephalopathy (HP:0200134)1.94654595
104Long palpebral fissure (HP:0000637)1.92939104
105Impaired social interactions (HP:0000735)1.91255989
106Abnormal social behavior (HP:0012433)1.91255989
107Chronic diarrhea (HP:0002028)1.91173787
108Absence seizures (HP:0002121)1.89680862
109Foot dorsiflexor weakness (HP:0009027)1.89265969
110Tracheomalacia (HP:0002779)1.88985039
111Recurrent sinusitis (HP:0011108)1.88280788
112Spontaneous hematomas (HP:0007420)1.88062484
113Laryngomalacia (HP:0001601)1.87887832
114Ankyloglossia (HP:0010296)1.86933634
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86909389
116Truncal ataxia (HP:0002078)1.86349010
117Distal lower limb amyotrophy (HP:0008944)1.85467084
118Abnormality of the lower motor neuron (HP:0002366)1.85364242
119Abnormality of the aortic arch (HP:0012303)1.84431417
120Gastrointestinal stroma tumor (HP:0100723)1.83283756
121Emphysema (HP:0002097)1.83054349
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83015380
123Lip pit (HP:0100267)1.82770083
124Hypoplastic ischia (HP:0003175)1.81606223
125Febrile seizures (HP:0002373)1.81489422
126Cellulitis (HP:0100658)1.81314213
127Abnormality of incisor morphology (HP:0011063)1.80401629
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.80248077
129Abnormality of the foot musculature (HP:0001436)1.79434257
130Aplasia involving bones of the upper limbs (HP:0009823)1.77133621
131Aplasia of the phalanges of the hand (HP:0009802)1.77133621
132Aplasia involving bones of the extremities (HP:0009825)1.77133621
133Urinary bladder sphincter dysfunction (HP:0002839)1.77070816
134Chest pain (HP:0100749)1.77030463
135Decreased motor nerve conduction velocity (HP:0003431)1.75882603
136Narrow palate (HP:0000189)1.74536075
137Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74227589
138Lower limb asymmetry (HP:0100559)1.74020369
139Supranuclear gaze palsy (HP:0000605)1.73938094
140Depressed nasal tip (HP:0000437)1.73897017
141Basal cell carcinoma (HP:0002671)1.73570359
142Poor eye contact (HP:0000817)1.71873342
143Steppage gait (HP:0003376)1.71858184
144Skin pits (HP:0100276)1.71102367
145Depression (HP:0000716)1.70901917
146Papilledema (HP:0001085)1.70586150
147Overgrowth (HP:0001548)1.70447097
148Slow-growing hair (HP:0002217)1.68442456
149Abnormality of hair growth rate (HP:0011363)1.68442456
150Oligodontia (HP:0000677)1.62466487
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59272967
152Interstitial pulmonary disease (HP:0006530)1.58906478
153Abnormality of saccadic eye movements (HP:0000570)1.57524711
154Abnormality of the ischium (HP:0003174)1.57303590
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56098669
156Accelerated skeletal maturation (HP:0005616)1.56027518
157Dislocated radial head (HP:0003083)1.55828404
158Periauricular skin pits (HP:0100277)1.54786745
159Preauricular pit (HP:0004467)1.54786745
160Abnormality of the radial head (HP:0003995)1.53947357
161Abnormal sex determination (HP:0012244)1.52774209
162Sex reversal (HP:0012245)1.52774209
163Diaphragmatic weakness (HP:0009113)1.52293998
164Transposition of the great arteries (HP:0001669)1.51982696
165Abnormal connection of the cardiac segments (HP:0011545)1.51982696
166Abnormal ventriculo-arterial connection (HP:0011563)1.51982696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.63701938
2TXK3.88416508
3EEF2K3.01580343
4MAPK152.92191164
5MAP3K102.51226724
6EPHA42.22897476
7ITK2.11728249
8ZAP702.07261056
9MAP3K142.04463984
10SIK11.97755241
11MAP3K91.86503023
12TAOK31.85941131
13TAOK11.83313096
14RPS6KA51.81506380
15IRAK11.80922611
16PRPF4B1.75112500
17AKT31.72772383
18NLK1.69564159
19GRK61.69449620
20CDK121.59083471
21RPS6KA11.55346593
22CHUK1.54561680
23NEK61.53025590
24EPHB11.50152428
25PRKCH1.49646675
26MAP3K131.49446788
27IKBKE1.48027315
28IKBKB1.45978857
29FGFR41.43315239
30TRIB31.40067672
31NTRK31.39607146
32JAK31.38707953
33STK101.36226324
34TAOK21.31729166
35HCK1.28928238
36TYRO31.28687713
37ALK1.28467071
38PNCK1.25664445
39TGFBR21.25443776
40DAPK21.24024142
41MAPK121.21696686
42DMPK1.20995007
43FES1.19840478
44SIK21.19752403
45RAF11.19147191
46STK381.17796089
47MAP3K71.17187447
48PASK1.16219252
49MAP3K11.15534332
50NTRK21.14654302
51IRAK21.13889284
52MAP3K111.12529162
53IRAK41.07917996
54FGFR31.07696270
55EPHA31.07671212
56PRKD31.04295590
57RIPK41.03674143
58TYK21.01039612
59RPS6KA40.98696555
60PIM20.97509666
61BMPR20.96852959
62TBK10.94818367
63LCK0.94661949
64PIM10.94536460
65RPS6KA20.93824736
66SGK30.90972389
67MARK20.88930058
68RIPK10.88324561
69PAK60.87900295
70STK110.87060684
71CAMK40.86030188
72RPS6KC10.85892524
73RPS6KL10.85892524
74KSR20.85671111
75MAP2K30.85335189
76PDPK10.84704659
77CAMK1D0.84179675
78CAMK1G0.83734506
79PDK10.83602051
80RPS6KA60.82640080
81FGFR10.80497585
82MAP3K20.79930883
83CAMKK10.79699481
84PKN20.79655011
85SYK0.79008243
86ICK0.78966877
87BLK0.77711265
88HIPK20.77638048
89PRKCQ0.76921164
90DDR20.74867645
91SGK20.74649463
92TEC0.73563860
93JAK20.73274408
94CDK50.73253233
95STK240.72080987
96JAK10.71716474
97ERN10.71659271
98MTOR0.70401315
99SMG10.69100338
100BRD40.66499219
101PDGFRB0.65705218
102INSRR0.64997132
103CLK10.64860781
104MAP3K30.62084668
105MAP2K20.62071234
106UHMK10.61957199
107RET0.60177515
108MARK30.60129434
109WNK10.59774077
110MAPK80.59706433
111MAPK40.57851414
112BMX0.57539204
113PRKD20.57264990
114DAPK10.56198408
115MST40.54612521
116PAK30.53628272
117TNK20.53096959
118FRK0.52833306
119BTK0.52618269
120SIK30.52207738
121MAP3K40.52027575
122MELK0.51502397
123SGK2230.51494796
124SGK4940.51494796
125LRRK20.51265136
126MAPK100.50859563
127MINK10.50503675
128FER0.50239286
129MAPK70.50179040
130MAPK10.49039258
131FGFR20.47759760
132CDC42BPA0.47703496
133CAMK10.46567172
134CDK190.44247153
135SGK10.42356481
136PTK2B0.41232208
137ROCK20.40771476

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046602.85045686
2Allograft rejection_Homo sapiens_hsa053302.57276117
3Primary immunodeficiency_Homo sapiens_hsa053402.45045240
4Osteoclast differentiation_Homo sapiens_hsa043802.17206263
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.06079791
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.87426362
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.76985687
8Asthma_Homo sapiens_hsa053101.71389544
9Autoimmune thyroid disease_Homo sapiens_hsa053201.66090167
10Circadian rhythm_Homo sapiens_hsa047101.56363408
11Long-term potentiation_Homo sapiens_hsa047201.56121628
12B cell receptor signaling pathway_Homo sapiens_hsa046621.52443684
13Acute myeloid leukemia_Homo sapiens_hsa052211.51798869
14MAPK signaling pathway_Homo sapiens_hsa040101.46114227
15Olfactory transduction_Homo sapiens_hsa047401.42363635
16Prolactin signaling pathway_Homo sapiens_hsa049171.41455133
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39275017
18Type II diabetes mellitus_Homo sapiens_hsa049301.35506233
19Circadian entrainment_Homo sapiens_hsa047131.34444719
20Type I diabetes mellitus_Homo sapiens_hsa049401.33962427
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28667626
22Chronic myeloid leukemia_Homo sapiens_hsa052201.28623432
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26253520
24Toxoplasmosis_Homo sapiens_hsa051451.23482833
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23198520
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22980661
27VEGF signaling pathway_Homo sapiens_hsa043701.22752107
28Amphetamine addiction_Homo sapiens_hsa050311.21314708
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.19902270
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17166918
31TNF signaling pathway_Homo sapiens_hsa046681.16206566
32Morphine addiction_Homo sapiens_hsa050321.15251723
33Gastric acid secretion_Homo sapiens_hsa049711.14323963
34Cocaine addiction_Homo sapiens_hsa050301.13307201
35Cholinergic synapse_Homo sapiens_hsa047251.12828880
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10935552
37Chemokine signaling pathway_Homo sapiens_hsa040621.10704759
38Glutamatergic synapse_Homo sapiens_hsa047241.09977059
39Renin secretion_Homo sapiens_hsa049241.09056876
40Measles_Homo sapiens_hsa051621.08915659
41Oxytocin signaling pathway_Homo sapiens_hsa049211.07959213
42Salivary secretion_Homo sapiens_hsa049701.07936217
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.04874702
44ErbB signaling pathway_Homo sapiens_hsa040121.03210749
45Synaptic vesicle cycle_Homo sapiens_hsa047211.02925573
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02105112
47Graft-versus-host disease_Homo sapiens_hsa053321.01824295
48Notch signaling pathway_Homo sapiens_hsa043301.01462038
49Influenza A_Homo sapiens_hsa051641.01443340
50Leishmaniasis_Homo sapiens_hsa051400.99981774
51* Hepatitis B_Homo sapiens_hsa051610.99620698
52GnRH signaling pathway_Homo sapiens_hsa049120.97174443
53Colorectal cancer_Homo sapiens_hsa052100.96843234
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96339293
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96284865
56Glioma_Homo sapiens_hsa052140.95126116
57Dopaminergic synapse_Homo sapiens_hsa047280.95018621
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92759532
59Dorso-ventral axis formation_Homo sapiens_hsa043200.91103415
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91097571
61Nicotine addiction_Homo sapiens_hsa050330.91072376
62Non-small cell lung cancer_Homo sapiens_hsa052230.90719639
63HTLV-I infection_Homo sapiens_hsa051660.90704576
64Viral myocarditis_Homo sapiens_hsa054160.90673266
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90539703
66Endometrial cancer_Homo sapiens_hsa052130.90053457
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88813550
68Platelet activation_Homo sapiens_hsa046110.88534637
69Ovarian steroidogenesis_Homo sapiens_hsa049130.88488517
70GABAergic synapse_Homo sapiens_hsa047270.85600568
71Prion diseases_Homo sapiens_hsa050200.85024269
72cAMP signaling pathway_Homo sapiens_hsa040240.83160751
73Insulin secretion_Homo sapiens_hsa049110.82750035
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82513856
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82403405
76Pancreatic cancer_Homo sapiens_hsa052120.82347536
77Estrogen signaling pathway_Homo sapiens_hsa049150.81833254
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.80027072
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78741727
80mTOR signaling pathway_Homo sapiens_hsa041500.76961409
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.75577500
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74860026
83Renal cell carcinoma_Homo sapiens_hsa052110.74608576
84Nitrogen metabolism_Homo sapiens_hsa009100.73796125
85Prostate cancer_Homo sapiens_hsa052150.73707202
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72596129
87Long-term depression_Homo sapiens_hsa047300.72595802
88Calcium signaling pathway_Homo sapiens_hsa040200.72590051
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71804648
90Pertussis_Homo sapiens_hsa051330.69916597
91Tuberculosis_Homo sapiens_hsa051520.69753389
92Inositol phosphate metabolism_Homo sapiens_hsa005620.67904118
93FoxO signaling pathway_Homo sapiens_hsa040680.67621885
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.67541849
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67408202
96Choline metabolism in cancer_Homo sapiens_hsa052310.67367111
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65742719
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65635967
99Ras signaling pathway_Homo sapiens_hsa040140.64104132
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63912334
101Rap1 signaling pathway_Homo sapiens_hsa040150.63818610
102Insulin resistance_Homo sapiens_hsa049310.63275561
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.62599528
104Shigellosis_Homo sapiens_hsa051310.62357017
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60492648
106Serotonergic synapse_Homo sapiens_hsa047260.59323134
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.58273303
108HIF-1 signaling pathway_Homo sapiens_hsa040660.57537275
109Apoptosis_Homo sapiens_hsa042100.57529706
110Amoebiasis_Homo sapiens_hsa051460.57508420
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57473580
112Hepatitis C_Homo sapiens_hsa051600.57266272
113Legionellosis_Homo sapiens_hsa051340.57188205
114Gap junction_Homo sapiens_hsa045400.55716482
115Endocytosis_Homo sapiens_hsa041440.55659901

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