EGR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38606563
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.33256771
3synaptic vesicle maturation (GO:0016188)5.94418570
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.92029070
5vocalization behavior (GO:0071625)5.65786023
6synaptic vesicle exocytosis (GO:0016079)5.55281436
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53019255
8epithelial cell fate commitment (GO:0072148)5.48958082
9regulation of glutamate receptor signaling pathway (GO:1900449)5.42350649
10locomotory exploration behavior (GO:0035641)5.36711248
11protein localization to synapse (GO:0035418)5.34048215
12glutamate secretion (GO:0014047)5.21345925
13regulation of neuronal synaptic plasticity (GO:0048168)5.15195495
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.14151913
15ionotropic glutamate receptor signaling pathway (GO:0035235)5.13477069
16regulation of synaptic vesicle exocytosis (GO:2000300)5.12274687
17glycerophospholipid catabolic process (GO:0046475)4.91713674
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.72123017
19neuronal action potential propagation (GO:0019227)4.71613125
20glutamate receptor signaling pathway (GO:0007215)4.64340385
21regulation of synaptic vesicle transport (GO:1902803)4.54945737
22synaptic transmission, glutamatergic (GO:0035249)4.49470663
23adaptation of signaling pathway (GO:0023058)4.47079586
24regulation of dendritic spine morphogenesis (GO:0061001)4.46273622
25exploration behavior (GO:0035640)4.45227540
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39780243
27neuron cell-cell adhesion (GO:0007158)4.30244407
28neurotransmitter secretion (GO:0007269)4.29676977
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.29541551
30neuron-neuron synaptic transmission (GO:0007270)4.27451419
31positive regulation of dendritic spine morphogenesis (GO:0061003)4.25534755
32positive regulation of membrane potential (GO:0045838)4.23063825
33dendritic spine morphogenesis (GO:0060997)4.21959137
34neurotransmitter-gated ion channel clustering (GO:0072578)4.19325417
35layer formation in cerebral cortex (GO:0021819)4.19239177
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.18725754
37regulation of synapse structural plasticity (GO:0051823)4.16929307
38positive regulation of synapse maturation (GO:0090129)4.14773056
39regulation of synaptic plasticity (GO:0048167)4.13352539
40insulin secretion (GO:0030073)4.03429740
41regulation of postsynaptic membrane potential (GO:0060078)4.03066593
42long-term synaptic potentiation (GO:0060291)4.01598714
43respiratory chain complex IV assembly (GO:0008535)4.01485274
44long-term memory (GO:0007616)3.96913702
45regulation of type B pancreatic cell apoptotic process (GO:2000674)3.89914894
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.89522349
47positive regulation of dendritic spine development (GO:0060999)3.84856899
48cellular ketone body metabolic process (GO:0046950)3.84314675
49regulation of dendritic spine development (GO:0060998)3.72680157
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.71976650
51regulation of vesicle fusion (GO:0031338)3.70294631
52behavioral fear response (GO:0001662)3.67709891
53behavioral defense response (GO:0002209)3.67709891
54cytochrome complex assembly (GO:0017004)3.65209414
55positive regulation of neurotransmitter secretion (GO:0001956)3.64931033
56regulation of glutamate secretion (GO:0014048)3.64750511
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62859037
58negative regulation of dendrite morphogenesis (GO:0050774)3.61669461
59neuron recognition (GO:0008038)3.57496383
60endocrine pancreas development (GO:0031018)3.57140969
61transmission of nerve impulse (GO:0019226)3.56434400
62dendritic spine organization (GO:0097061)3.55656481
63alanine transport (GO:0032328)3.55633050
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51134855
65cellular potassium ion homeostasis (GO:0030007)3.50173238
66positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.49360774
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47289201
68positive regulation of neurotransmitter transport (GO:0051590)3.47147718
69fear response (GO:0042596)3.46698844
70endothelial cell chemotaxis (GO:0035767)3.44544078
71neuromuscular process controlling posture (GO:0050884)3.42700274
72regulation of neurotransmitter secretion (GO:0046928)3.42298916
73activation of protein kinase A activity (GO:0034199)3.42051942
74gamma-aminobutyric acid transport (GO:0015812)3.41079856
75neuromuscular process controlling balance (GO:0050885)3.41059115
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40374816
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.38169996
78synaptic vesicle endocytosis (GO:0048488)3.36142654
79regulation of female receptivity (GO:0045924)3.35289596
80neurotransmitter transport (GO:0006836)3.35195756
81detection of calcium ion (GO:0005513)3.34635576
82ketone body metabolic process (GO:1902224)3.33445873
83behavioral response to cocaine (GO:0048148)3.30523916
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28969297
85regulation of neurotransmitter uptake (GO:0051580)3.27495175
86positive regulation of insulin secretion (GO:0032024)3.26637333
87negative regulation of amino acid transport (GO:0051956)3.26474674
88membrane depolarization (GO:0051899)3.26361428
89long term synaptic depression (GO:0060292)3.26216507
90auditory receptor cell differentiation (GO:0042491)3.25746109
91response to histamine (GO:0034776)3.25663582
92learning (GO:0007612)3.24816586
93chemosensory behavior (GO:0007635)3.23634776
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18064482
95positive regulation of gluconeogenesis (GO:0045722)3.17971692
96regulation of neurotransmitter levels (GO:0001505)3.16766942
97regulation of gonadotropin secretion (GO:0032276)3.16554413
98regulation of synaptic transmission (GO:0050804)3.14231853
99regulation of neurotransmitter transport (GO:0051588)3.13934990
100positive regulation of synaptic transmission (GO:0050806)3.13356541
101regulation of synapse maturation (GO:0090128)3.12913250
102behavioral response to nicotine (GO:0035095)3.12855214
103postsynaptic membrane organization (GO:0001941)3.11889805
104auditory behavior (GO:0031223)3.11409630
105proline transport (GO:0015824)3.09458967
106presynaptic membrane assembly (GO:0097105)3.09235287
107axonal fasciculation (GO:0007413)3.09112757
108mating behavior (GO:0007617)3.08303870
109regulation of voltage-gated calcium channel activity (GO:1901385)3.06484088
110response to amphetamine (GO:0001975)3.05450732
111dentate gyrus development (GO:0021542)3.05185099
112synaptic transmission, dopaminergic (GO:0001963)3.04986952
113regulation of calcium ion-dependent exocytosis (GO:0017158)3.04896854
114female mating behavior (GO:0060180)3.03724385
115neuronal ion channel clustering (GO:0045161)3.03617115
116L-alpha-amino acid transmembrane transport (GO:1902475)3.03482344
117synaptic transmission (GO:0007268)3.03183505
118* cellular response to gonadotropin stimulus (GO:0071371)3.01041613
119regulation of action potential (GO:0098900)3.00771434
120membrane hyperpolarization (GO:0060081)3.00415962
121positive regulation of action potential (GO:0045760)2.99821639
122positive regulation of meiosis (GO:0045836)2.99211445
123sodium ion export (GO:0071436)2.98847540
124inositol phosphate catabolic process (GO:0071545)2.98744130
125prepulse inhibition (GO:0060134)2.98390855
126cerebellar Purkinje cell differentiation (GO:0021702)2.96327670
127peptide hormone secretion (GO:0030072)2.95799923
128innervation (GO:0060384)2.94642736
129negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93549639
130regulation of glucokinase activity (GO:0033131)2.91763545
131regulation of hexokinase activity (GO:1903299)2.91763545
132presynaptic membrane organization (GO:0097090)2.89840929
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.88849475
134inositol phosphate dephosphorylation (GO:0046855)2.88849475
135peptide secretion (GO:0002790)2.84427527
136negative regulation of execution phase of apoptosis (GO:1900118)2.84211709
137regulation of insulin secretion (GO:0050796)2.83310389
138serotonin metabolic process (GO:0042428)2.81112290
139signal release (GO:0023061)2.79827290
140negative regulation of dendrite development (GO:2000171)2.78790228
141astrocyte differentiation (GO:0048708)2.78635973
142response to gravity (GO:0009629)2.76888076
143zinc ion homeostasis (GO:0055069)2.76364977
144protein localization to cilium (GO:0061512)2.74799089
145regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72892368
146regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.71754165
147regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.71754165
148negative regulation of activin receptor signaling pathway (GO:0032926)2.70048979
149neuromuscular synaptic transmission (GO:0007274)2.69798937
150positive regulation of peptide hormone secretion (GO:0090277)2.67425314
151regulation of synaptic transmission, dopaminergic (GO:0032225)2.62194831
152positive regulation of peptide secretion (GO:0002793)2.61209740
153type B pancreatic cell development (GO:0003323)2.60715806
154erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60668436
155L-phenylalanine catabolic process (GO:0006559)2.60668436
156primary amino compound metabolic process (GO:1901160)2.58631534
157protein targeting to Golgi (GO:0000042)2.57896157
158regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.57653510
159positive regulation of T cell differentiation in thymus (GO:0033089)2.56801235
160regulation of peptide hormone secretion (GO:0090276)2.56042921
161neuron fate specification (GO:0048665)2.55693673
162nitric oxide biosynthetic process (GO:0006809)2.55220071
163adrenergic receptor signaling pathway (GO:0071875)2.52353997
164regulation of peptide secretion (GO:0002791)2.51251142
165response to corticosterone (GO:0051412)2.50771771
166regulation of oxidative phosphorylation (GO:0002082)2.50233798
167platelet dense granule organization (GO:0060155)2.49413245
168protein localization to Golgi apparatus (GO:0034067)2.46226525
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46031262
170response to dietary excess (GO:0002021)2.45816312
171catecholamine transport (GO:0051937)2.45636326
172sex determination (GO:0007530)2.45127824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.75085050
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.83554182
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.28366536
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25457308
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.25415493
6GBX2_23144817_ChIP-Seq_PC3_Human3.25003906
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21293647
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.90756777
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86203189
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86203189
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82246427
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.79258605
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.67196771
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63991202
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63548574
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62106390
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59698953
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56426952
19DROSHA_22980978_ChIP-Seq_HELA_Human2.47773552
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42925256
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42431357
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.38744530
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38591401
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.37636456
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.34303120
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.24367115
27* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99055153
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92227449
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80742759
30AR_21572438_ChIP-Seq_LNCaP_Human1.73738787
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.72160216
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70688549
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69481897
34TAF15_26573619_Chip-Seq_HEK293_Human1.65623261
35SMAD4_21799915_ChIP-Seq_A2780_Human1.60043853
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55085621
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54885841
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54242282
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52496305
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47496079
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43142973
42* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39408539
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36647708
44* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34441831
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33152083
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.32273582
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.30541744
48P300_19829295_ChIP-Seq_ESCs_Human1.28987476
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.28580267
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28486207
51HTT_18923047_ChIP-ChIP_STHdh_Human1.28096442
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27293366
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27205816
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25824807
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.23526800
56* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22993283
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21591748
58ZNF274_21170338_ChIP-Seq_K562_Hela1.20788356
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.20093547
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19886569
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19572140
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19368096
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18954027
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18564351
65STAT3_23295773_ChIP-Seq_U87_Human1.18405009
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18340314
67RNF2_27304074_Chip-Seq_NSC_Mouse1.16777549
68* CBX2_27304074_Chip-Seq_ESCs_Mouse1.15862989
69AR_25329375_ChIP-Seq_VCAP_Human1.15727550
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15480131
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12932101
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12436856
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12244486
74VDR_22108803_ChIP-Seq_LS180_Human1.12012771
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11885371
76AR_19668381_ChIP-Seq_PC3_Human1.11463657
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11321182
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10720305
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10476444
80BCAT_22108803_ChIP-Seq_LS180_Human1.09687408
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.09508746
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09097963
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09091338
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08172945
85TP53_22573176_ChIP-Seq_HFKS_Human1.07258687
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.07144520
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06982100
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05789785
89KDM2B_26808549_Chip-Seq_K562_Human1.05662389
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04954923
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04954923
92ER_23166858_ChIP-Seq_MCF-7_Human1.04434161
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04289670
94FUS_26573619_Chip-Seq_HEK293_Human1.03871337
95IGF1R_20145208_ChIP-Seq_DFB_Human1.03691887
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02518865
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.01585040
98TCF4_22108803_ChIP-Seq_LS180_Human1.00822919
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00515798
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99643712
101SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99160774
102P53_22387025_ChIP-Seq_ESCs_Mouse0.98707993
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97897336
104CBP_20019798_ChIP-Seq_JUKART_Human0.97897336
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.97663936
106TCF4_23295773_ChIP-Seq_U87_Human0.97494472
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96847583
108* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96349427
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96331318
110NCOR_22424771_ChIP-Seq_293T_Human0.95750925
111SOX2_18555785_Chip-Seq_ESCs_Mouse0.95215626
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95159682
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.94318301
114TP53_16413492_ChIP-PET_HCT116_Human0.94137002
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93733017
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92876746
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92850857
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92579292
119RUNX2_22187159_ChIP-Seq_PCA_Human0.92549435
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.92519678
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91646163
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90316305
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90103316
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.89875899
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.89193618
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88729519
127CTCF_27219007_Chip-Seq_Bcells_Human0.88677132
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88582404
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88374742
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87119386
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86910582
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.85934463
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83620217
134JUN_21703547_ChIP-Seq_K562_Human0.82178174
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80915881
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.79256759
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78465439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.17761550
2MP0003880_abnormal_central_pattern4.99692844
3MP0003635_abnormal_synaptic_transmissio4.46991529
4MP0004270_analgesia3.73071654
5MP0009745_abnormal_behavioral_response3.67444577
6MP0002063_abnormal_learning/memory/cond3.63726552
7MP0002822_catalepsy3.48464706
8MP0002064_seizures3.27765621
9MP0009046_muscle_twitch3.21805365
10MP0002572_abnormal_emotion/affect_behav3.02349250
11MP0001501_abnormal_sleep_pattern2.84947958
12MP0001968_abnormal_touch/_nociception2.79929184
13MP0003195_calcinosis2.76667900
14MP0002272_abnormal_nervous_system2.68564295
15MP0006072_abnormal_retinal_apoptosis2.62772328
16MP0005379_endocrine/exocrine_gland_phen2.54940064
17MP0001486_abnormal_startle_reflex2.49980032
18MP0002163_abnormal_gland_morphology2.36699074
19MP0005423_abnormal_somatic_nervous2.35003900
20MP0008877_abnormal_DNA_methylation2.22047571
21MP0002734_abnormal_mechanical_nocicepti2.19575880
22MP0001440_abnormal_grooming_behavior2.16841380
23MP0002736_abnormal_nociception_after2.15654172
24MP0002254_reproductive_system_inflammat2.09915056
25MP0003011_delayed_dark_adaptation2.04142355
26MP0003329_amyloid_beta_deposits2.02044417
27MP0002735_abnormal_chemical_nociception1.97866501
28MP0003172_abnormal_lysosome_physiology1.94449700
29MP0001944_abnormal_pancreas_morphology1.94360765
30MP0005646_abnormal_pituitary_gland1.84412222
31MP0002693_abnormal_pancreas_physiology1.83169394
32MP0004924_abnormal_behavior1.82959146
33MP0005386_behavior/neurological_phenoty1.82959146
34MP0002557_abnormal_social/conspecific_i1.76803495
35MP0003879_abnormal_hair_cell1.74020078
36MP0008569_lethality_at_weaning1.73685154
37MP0004811_abnormal_neuron_physiology1.72660891
38MP0002067_abnormal_sensory_capabilities1.70917511
39MP0002909_abnormal_adrenal_gland1.70891617
40MP0002733_abnormal_thermal_nociception1.68835716
41MP0001970_abnormal_pain_threshold1.67600243
42MP0003787_abnormal_imprinting1.64450292
43MP0009780_abnormal_chondrocyte_physiolo1.64325997
44MP0002638_abnormal_pupillary_reflex1.60433411
45MP0002184_abnormal_innervation1.58191738
46MP0002102_abnormal_ear_morphology1.55566238
47MP0000778_abnormal_nervous_system1.53638637
48MP0001529_abnormal_vocalization1.51300996
49MP0004858_abnormal_nervous_system1.47679737
50MP0010329_abnormal_lipoprotein_level1.47227115
51MP0004019_abnormal_vitamin_homeostasis1.46936152
52MP0006276_abnormal_autonomic_nervous1.40616259
53MP0001502_abnormal_circadian_rhythm1.39557597
54MP0001984_abnormal_olfaction1.36444499
55MP0002066_abnormal_motor_capabilities/c1.34534261
56MP0002139_abnormal_hepatobiliary_system1.34033307
57MP0000955_abnormal_spinal_cord1.32142790
58MP0001756_abnormal_urination1.30501991
59MP0001188_hyperpigmentation1.28468906
60MP0003633_abnormal_nervous_system1.28457731
61MP0002882_abnormal_neuron_morphology1.27310733
62MP0001905_abnormal_dopamine_level1.26901083
63MP0002078_abnormal_glucose_homeostasis1.23735830
64MP0008961_abnormal_basal_metabolism1.22564624
65MP0005253_abnormal_eye_physiology1.17080197
66MP0003878_abnormal_ear_physiology1.16788036
67MP0005377_hearing/vestibular/ear_phenot1.16788036
68MP0003075_altered_response_to1.16202341
69MP0005448_abnormal_energy_balance1.12516009
70MP0005332_abnormal_amino_acid1.12254950
71MP0003122_maternal_imprinting1.11789466
72MP0003631_nervous_system_phenotype1.10967199
73MP0005220_abnormal_exocrine_pancreas1.10713250
74MP0004885_abnormal_endolymph1.09269806
75MP0005645_abnormal_hypothalamus_physiol1.07856495
76MP0008872_abnormal_physiological_respon1.06730559
77MP0000013_abnormal_adipose_tissue1.06595154
78MP0003953_abnormal_hormone_level1.04301449
79MP0004142_abnormal_muscle_tone1.02976958
80MP0002152_abnormal_brain_morphology1.01870131
81MP0000604_amyloidosis1.00451314
82MP0000751_myopathy0.99153792
83MP0005167_abnormal_blood-brain_barrier0.97235021
84MP0008874_decreased_physiological_sensi0.96436518
85MP0005623_abnormal_meninges_morphology0.94439882
86MP0005409_darkened_coat_color0.92834969
87MP0000569_abnormal_digit_pigmentation0.91184104
88MP0003123_paternal_imprinting0.90903146
89MP0010234_abnormal_vibrissa_follicle0.89995785
90MP0002069_abnormal_eating/drinking_beha0.88819518
91MP0000639_abnormal_adrenal_gland0.88124770
92MP0004484_altered_response_of0.87813094
93MP0005410_abnormal_fertilization0.87228403
94MP0001177_atelectasis0.85624665
95MP0004145_abnormal_muscle_electrophysio0.85060545
96MP0002277_abnormal_respiratory_mucosa0.83843517
97MP0008995_early_reproductive_senescence0.82455925
98MP0004085_abnormal_heartbeat0.80971138
99MP0000538_abnormal_urinary_bladder0.80532274
100MP0004742_abnormal_vestibular_system0.80228330
101MP0003045_fibrosis0.78792571
102MP0002229_neurodegeneration0.78394129
103MP0001765_abnormal_ion_homeostasis0.76438783
104MP0005084_abnormal_gallbladder_morpholo0.76056987
105* MP0003698_abnormal_male_reproductive0.75001669
106MP0003632_abnormal_nervous_system0.74145489
107MP0003283_abnormal_digestive_organ0.73681209
108MP0000003_abnormal_adipose_tissue0.72938677
109MP0005535_abnormal_body_temperature0.71664109
110MP0003690_abnormal_glial_cell0.71301579
111MP0001963_abnormal_hearing_physiology0.70676072
112MP0000372_irregular_coat_pigmentation0.70264947
113MP0004510_myositis0.70254034
114MP0000631_abnormal_neuroendocrine_gland0.69242200
115MP0003890_abnormal_embryonic-extraembry0.66406908
116MP0003634_abnormal_glial_cell0.66178353
117MP0005636_abnormal_mineral_homeostasis0.66168864
118MP0010386_abnormal_urinary_bladder0.64914367
119MP0005058_abnormal_lysosome_morphology0.64746411
120MP0006036_abnormal_mitochondrial_physio0.64671678
121MP0002837_dystrophic_cardiac_calcinosis0.64199694
122MP0006292_abnormal_olfactory_placode0.64147862
123MP0005551_abnormal_eye_electrophysiolog0.63305184
124MP0000920_abnormal_myelination0.61890789
125MP0002876_abnormal_thyroid_physiology0.61347484
126MP0002234_abnormal_pharynx_morphology0.61067163
127MP0001485_abnormal_pinna_reflex0.57505727
128MP0002090_abnormal_vision0.57454828
129MP0004215_abnormal_myocardial_fiber0.55464276
130MP0001664_abnormal_digestion0.54954083
131MP0003121_genomic_imprinting0.54232393
132MP0002752_abnormal_somatic_nervous0.53796409
133MP0005166_decreased_susceptibility_to0.51797580
134MP0005499_abnormal_olfactory_system0.51193828
135MP0005394_taste/olfaction_phenotype0.51193828

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68150375
2Myokymia (HP:0002411)7.41825048
3Focal seizures (HP:0007359)6.07004775
4Visual hallucinations (HP:0002367)5.23314735
5Epileptic encephalopathy (HP:0200134)4.93868674
6Atonic seizures (HP:0010819)4.81183342
7Febrile seizures (HP:0002373)4.45637972
8Abnormality of the lower motor neuron (HP:0002366)4.22883275
9Absence seizures (HP:0002121)4.20016702
10Generalized tonic-clonic seizures (HP:0002069)3.95120819
11Impaired vibration sensation in the lower limbs (HP:0002166)3.93815800
12Dialeptic seizures (HP:0011146)3.86468810
13Progressive cerebellar ataxia (HP:0002073)3.64879024
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.59113226
15Poor eye contact (HP:0000817)3.55861194
16Anxiety (HP:0000739)3.52204770
17Action tremor (HP:0002345)3.50352780
18Gaze-evoked nystagmus (HP:0000640)3.47555868
19Broad-based gait (HP:0002136)3.47343368
20Hyperventilation (HP:0002883)3.42319977
21Depression (HP:0000716)3.39673340
22Ketoacidosis (HP:0001993)3.39252352
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25153087
24Amblyopia (HP:0000646)3.22675868
25Urinary bladder sphincter dysfunction (HP:0002839)3.21155970
26Dysmetria (HP:0001310)3.18365548
27Intestinal atresia (HP:0011100)3.12815896
28Impaired social interactions (HP:0000735)3.11862922
29Abnormal social behavior (HP:0012433)3.11862922
30Increased CSF protein (HP:0002922)3.11694964
31Dysdiadochokinesis (HP:0002075)3.01632212
32Ankle clonus (HP:0011448)2.99954661
33Supranuclear gaze palsy (HP:0000605)2.98543445
34Poor suck (HP:0002033)2.98124309
35Hypoglycemic coma (HP:0001325)2.96455954
36Abnormality of the corticospinal tract (HP:0002492)2.92236101
37Congenital malformation of the right heart (HP:0011723)2.91660909
38Double outlet right ventricle (HP:0001719)2.91660909
39Amyotrophic lateral sclerosis (HP:0007354)2.89968193
40Polyphagia (HP:0002591)2.88632938
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.86343734
42Urinary urgency (HP:0000012)2.85601594
43Hyperglycemia (HP:0003074)2.85050007
44Hyperinsulinemic hypoglycemia (HP:0000825)2.83663920
45Cerebral inclusion bodies (HP:0100314)2.80714183
46Impaired smooth pursuit (HP:0007772)2.75970741
47Large for gestational age (HP:0001520)2.75251019
48Stereotypic behavior (HP:0000733)2.72938359
49Aplasia/hypoplasia of the uterus (HP:0008684)2.70457161
50Abnormal eating behavior (HP:0100738)2.67769660
51Vascular calcification (HP:0004934)2.66326286
52Insidious onset (HP:0003587)2.64196768
53Termporal pattern (HP:0011008)2.64196768
54Annular pancreas (HP:0001734)2.64139946
55Sex reversal (HP:0012245)2.63910591
56Abnormal sex determination (HP:0012244)2.63910591
57Spastic gait (HP:0002064)2.63106224
58Absent speech (HP:0001344)2.61876523
59Hypoglycemic seizures (HP:0002173)2.60310420
60Genetic anticipation (HP:0003743)2.60283247
61Postural instability (HP:0002172)2.59692479
62Drooling (HP:0002307)2.59572147
63Excessive salivation (HP:0003781)2.59572147
64Hypoalbuminemia (HP:0003073)2.58681716
65Abnormal albumin level (HP:0012116)2.58681716
66Epileptiform EEG discharges (HP:0011182)2.57946267
67Delusions (HP:0000746)2.52552943
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52215184
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.52215184
70Testicular neoplasm (HP:0010788)2.50572609
71Hepatic necrosis (HP:0002605)2.50459375
72Abnormality of the 1st metacarpal (HP:0010009)2.50197470
73Hypothermia (HP:0002045)2.49675683
74Torticollis (HP:0000473)2.49297728
75Truncal ataxia (HP:0002078)2.48880284
76Hypoplasia of the uterus (HP:0000013)2.47239678
77Focal dystonia (HP:0004373)2.44154187
78Pendular nystagmus (HP:0012043)2.43532123
79Abnormality of ocular smooth pursuit (HP:0000617)2.42788416
80Increased circulating renin level (HP:0000848)2.42397541
81Vacuolated lymphocytes (HP:0001922)2.41541868
82Impaired vibratory sensation (HP:0002495)2.41416863
83EEG with generalized epileptiform discharges (HP:0011198)2.40286736
84Gonadal dysgenesis (HP:0000133)2.37931791
85Neurofibrillary tangles (HP:0002185)2.34787569
86Hepatocellular necrosis (HP:0001404)2.34057155
87Progressive inability to walk (HP:0002505)2.31875277
88Short tibia (HP:0005736)2.31582567
89Hemiparesis (HP:0001269)2.30850043
90Ventricular fibrillation (HP:0001663)2.27812518
91Hypomagnesemia (HP:0002917)2.27559028
92Abnormality of the labia minora (HP:0012880)2.26918969
93Bradykinesia (HP:0002067)2.26036628
94Hypsarrhythmia (HP:0002521)2.25380721
95Insulin-resistant diabetes mellitus (HP:0000831)2.24470624
96Late onset (HP:0003584)2.21111689
97Status epilepticus (HP:0002133)2.20396284
98Mutism (HP:0002300)2.19098761
99Intention tremor (HP:0002080)2.17004253
100Cardiovascular calcification (HP:0011915)2.16130906
101Progressive neurologic deterioration (HP:0002344)2.15936711
102Inability to walk (HP:0002540)2.15848670
103Obstructive sleep apnea (HP:0002870)2.15360712
104Nuclear cataract (HP:0100018)2.13629092
105Abnormality of polysaccharide metabolism (HP:0011012)2.12818495
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12818495
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12818495
108Postural tremor (HP:0002174)2.12600847
109Megalencephaly (HP:0001355)2.12384206
110Incomplete penetrance (HP:0003829)2.12296220
111Enlarged penis (HP:0000040)2.11592830
112Scanning speech (HP:0002168)2.10922721
113Thickened helices (HP:0000391)2.10694780
114Pointed chin (HP:0000307)2.10352550
115Polydipsia (HP:0001959)2.09996047
116Abnormal drinking behavior (HP:0030082)2.09996047
117Abnormality of the pancreatic islet cells (HP:0006476)2.09086689
118Abnormality of endocrine pancreas physiology (HP:0012093)2.09086689
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.08895274
120Labial hypoplasia (HP:0000066)2.08619175
121Limb dystonia (HP:0002451)2.08616490
122Ketosis (HP:0001946)2.08021251
123Lower limb muscle weakness (HP:0007340)2.07897712
124Agitation (HP:0000713)2.07859933
125Abnormal rod and cone electroretinograms (HP:0008323)2.07817357
126Craniofacial dystonia (HP:0012179)2.07661190
127Papilledema (HP:0001085)2.07193555
128Generalized myoclonic seizures (HP:0002123)2.06568182
129Decreased circulating renin level (HP:0003351)2.05913165
130Gait ataxia (HP:0002066)2.05053849
131Bundle branch block (HP:0011710)2.03523620
132Dysmetric saccades (HP:0000641)2.01778805
133Resting tremor (HP:0002322)1.99733699
134Pheochromocytoma (HP:0002666)1.98292457
135Large eyes (HP:0001090)1.97999950
136Menstrual irregularities (HP:0000858)1.96877554
137Psychosis (HP:0000709)1.96138042
138Albinism (HP:0001022)1.96062949
139Abnormality of binocular vision (HP:0011514)1.95197742
140Diplopia (HP:0000651)1.95197742
141Epidermoid cyst (HP:0200040)1.94081825
142Abnormality of vitamin B metabolism (HP:0004340)1.93524503
143Muscular hypotonia of the trunk (HP:0008936)1.92021935
144Fetal akinesia sequence (HP:0001989)1.91994025
145Mitochondrial inheritance (HP:0001427)1.91564969
146Tetraplegia (HP:0002445)1.91153722
147Blue irides (HP:0000635)1.91063342
148Severe visual impairment (HP:0001141)1.89375715
149Hemiplegia (HP:0002301)1.88717734
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88497600
151Sleep apnea (HP:0010535)1.88220698
152Hyperlipoproteinemia (HP:0010980)1.87736412
153Retinal dysplasia (HP:0007973)1.87626024
154Truncus arteriosus (HP:0001660)1.85353009
155Upper limb muscle weakness (HP:0003484)1.84994201
156Urinary glycosaminoglycan excretion (HP:0003541)1.84712499
157Mucopolysacchariduria (HP:0008155)1.84712499
158Abnormality of vitamin metabolism (HP:0100508)1.83795671
159Generalized hypopigmentation (HP:0007513)1.83726980
160Ankyloglossia (HP:0010296)1.83168966
161Failure to thrive in infancy (HP:0001531)1.82299464
162Progressive macrocephaly (HP:0004481)1.82005729
163Shoulder girdle muscle weakness (HP:0003547)1.81743483
164Lower limb amyotrophy (HP:0007210)1.81706266
165Neoplasm of the heart (HP:0100544)1.81690043
166Abnormal EKG (HP:0003115)1.81660038
167Prominent supraorbital ridges (HP:0000336)1.80171322
168Congenital sensorineural hearing impairment (HP:0008527)1.79044418
169Glycosuria (HP:0003076)1.78756209
170Abnormality of urine glucose concentration (HP:0011016)1.78756209
171Iris hypopigmentation (HP:0007730)1.78667535
172Attenuation of retinal blood vessels (HP:0007843)1.78030837
173Deep palmar crease (HP:0006191)1.77120182
174Rapidly progressive (HP:0003678)1.75707790
175Achilles tendon contracture (HP:0001771)1.75535774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.67689047
2NTRK34.53866282
3MAP3K94.04896106
4FRK3.93137944
5MAP4K22.80067576
6DAPK22.77150716
7KSR22.66488106
8MAP3K42.62062812
9RIPK42.61387561
10PRKD32.46523483
11MINK12.38567235
12PHKG22.31288122
13PHKG12.31288122
14MAP2K72.30795598
15GRK12.19940633
16PAK62.11515449
17NTRK22.07213695
18MAP3K132.02529543
19DAPK11.99102197
20MAP2K61.98052920
21ARAF1.94763295
22MST41.89921992
23KSR11.83542837
24PTK2B1.76582369
25MAP3K121.73643370
26MAP2K41.73414854
27PLK21.72128970
28FES1.64171910
29TNIK1.62925575
30NTRK11.60752095
31CAMKK11.59424161
32TNK21.52986179
33CDK51.52099644
34MARK11.46388464
35PRPF4B1.42843169
36CASK1.41137246
37GRK51.40743763
38PNCK1.37431499
39MAP3K21.37315249
40NLK1.31851936
41CSNK1G11.29256521
42EIF2AK31.26278137
43EPHA31.25174098
44ADRBK21.24640989
45STK381.23068019
46RAF11.20557020
47TYRO31.19919654
48CDK191.18666474
49PRKCG1.18622855
50FGFR21.11160827
51CSNK1G31.10392387
52MAPK131.10366174
53BMPR21.08275979
54SIK21.08096593
55UHMK11.05493953
56CAMK2A1.05488863
57CAMK11.03085805
58TAOK11.02454766
59WNK30.99331192
60BMPR1B0.98551445
61TESK10.97606039
62CHUK0.96935713
63IRAK10.94651584
64RPS6KA50.94303264
65MAP3K10.93307242
66CAMK2B0.92604423
67MKNK20.91433442
68TAOK20.88187453
69MAP2K20.87734085
70ERBB30.87643755
71CDK140.87565300
72STK110.84730961
73MAP3K50.83835675
74IRAK20.82460897
75TRIM280.81700154
76NME10.81295813
77MUSK0.80461133
78CDK180.80158716
79CDK150.78146187
80CSNK1A1L0.77346634
81FGFR30.76359000
82FGR0.75412848
83BRD40.72491987
84STK38L0.71171963
85CAMKK20.70899384
86NUAK10.69106266
87PDK10.67764528
88CDK11A0.66701809
89PAK30.64993737
90IKBKB0.64710271
91CSNK1A10.64283345
92SGK10.64138446
93PRKCH0.62364391
94DYRK1A0.59956147
95OXSR10.59795042
96FER0.59717325
97PRKCI0.59575068
98INSRR0.59267948
99PDPK10.59227646
100SIK30.59051582
101PINK10.56264150
102LMTK20.55360846
103RET0.54936815
104CAMK1D0.53783383
105HIPK20.50791169
106MAP2K10.50656532
107PRKCQ0.50419757
108CDK30.50359763
109ALK0.50006061
110SGK4940.49557890
111SGK2230.49557890
112MARK20.48545049
113DMPK0.47158510
114TEC0.47101152
115DAPK30.47001217
116CCNB10.46038995
117CAMK2D0.44958589
118CAMK40.44792012
119WNK40.43630203
120CSNK1D0.42755208
121RPS6KA30.42255798
122LIMK10.42124491
123PRKAA10.41615320
124BRAF0.41444937
125PRKCZ0.41355505
126BRSK10.41100398
127RPS6KA10.40811363
128CAMK2G0.40712190
129PRKCE0.38316579
130TLK10.38286787
131LATS20.38248107
132PDK40.38046399
133PDK30.38046399
134MOS0.37982385
135PRKD20.37757359
136MAPK70.37312390
137FYN0.36037026
138MAP3K70.32593708
139MAPK120.32335335
140MAPK100.31634834
141PRKCB0.28892857
142MAPKAPK50.27496485
143PRKCA0.27373174
144CSNK1G20.27345341
145MAP3K110.25693682
146MAPK80.24665308
147AKT30.24447453
148SGK20.24244748
149GRK60.23441237

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.04605803
2Nicotine addiction_Homo sapiens_hsa050333.68388502
3Synaptic vesicle cycle_Homo sapiens_hsa047213.18854226
4Long-term potentiation_Homo sapiens_hsa047203.12246034
5Amphetamine addiction_Homo sapiens_hsa050312.98618801
6Circadian entrainment_Homo sapiens_hsa047132.89513440
7Olfactory transduction_Homo sapiens_hsa047402.87103830
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73015452
9Glutamatergic synapse_Homo sapiens_hsa047242.60834720
10GABAergic synapse_Homo sapiens_hsa047272.56802055
11Morphine addiction_Homo sapiens_hsa050322.46431546
12Butanoate metabolism_Homo sapiens_hsa006502.32610267
13Dopaminergic synapse_Homo sapiens_hsa047282.32436008
14Salivary secretion_Homo sapiens_hsa049702.25842324
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22364573
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13190289
17Insulin secretion_Homo sapiens_hsa049112.00689029
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97116826
19Cholinergic synapse_Homo sapiens_hsa047251.93848956
20Gastric acid secretion_Homo sapiens_hsa049711.92762709
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90172720
22Oxytocin signaling pathway_Homo sapiens_hsa049211.88331527
23Renin secretion_Homo sapiens_hsa049241.84459232
24Long-term depression_Homo sapiens_hsa047301.81994799
25Cocaine addiction_Homo sapiens_hsa050301.78049530
26Protein export_Homo sapiens_hsa030601.76130853
27Calcium signaling pathway_Homo sapiens_hsa040201.74193432
28Taste transduction_Homo sapiens_hsa047421.71489402
29Sulfur metabolism_Homo sapiens_hsa009201.69591255
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69348049
31Serotonergic synapse_Homo sapiens_hsa047261.62147564
32GnRH signaling pathway_Homo sapiens_hsa049121.59953951
33Collecting duct acid secretion_Homo sapiens_hsa049661.56551819
34Vitamin B6 metabolism_Homo sapiens_hsa007501.45330502
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39950202
36cAMP signaling pathway_Homo sapiens_hsa040241.34327367
37Other glycan degradation_Homo sapiens_hsa005111.34327167
38Gap junction_Homo sapiens_hsa045401.32907295
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30227743
40Sphingolipid metabolism_Homo sapiens_hsa006001.28533079
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26381739
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22329570
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21316819
44Estrogen signaling pathway_Homo sapiens_hsa049151.21296155
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20297469
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19932998
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18993322
48Melanogenesis_Homo sapiens_hsa049161.18936192
49Glioma_Homo sapiens_hsa052141.18675231
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14809827
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12378619
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12004110
53Oocyte meiosis_Homo sapiens_hsa041141.10535560
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.09336605
55Selenocompound metabolism_Homo sapiens_hsa004501.07758523
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.07367431
57Cardiac muscle contraction_Homo sapiens_hsa042601.03344533
58Dorso-ventral axis formation_Homo sapiens_hsa043201.03206069
59Folate biosynthesis_Homo sapiens_hsa007901.01460614
60Mineral absorption_Homo sapiens_hsa049780.99915870
61Vibrio cholerae infection_Homo sapiens_hsa051100.99264793
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.97840857
63ErbB signaling pathway_Homo sapiens_hsa040120.97015132
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95614724
65Axon guidance_Homo sapiens_hsa043600.95385356
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94583919
67Type II diabetes mellitus_Homo sapiens_hsa049300.94380530
68Tryptophan metabolism_Homo sapiens_hsa003800.92147996
69Glutathione metabolism_Homo sapiens_hsa004800.91961328
70Peroxisome_Homo sapiens_hsa041460.89292599
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.86074562
72Regulation of autophagy_Homo sapiens_hsa041400.85989382
73Choline metabolism in cancer_Homo sapiens_hsa052310.83424926
74VEGF signaling pathway_Homo sapiens_hsa043700.82843830
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78953935
76Pancreatic secretion_Homo sapiens_hsa049720.78922167
77Lysosome_Homo sapiens_hsa041420.77776532
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76889845
79Steroid biosynthesis_Homo sapiens_hsa001000.75415913
80ABC transporters_Homo sapiens_hsa020100.72352279
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72008050
82MAPK signaling pathway_Homo sapiens_hsa040100.71502218
83Thyroid hormone synthesis_Homo sapiens_hsa049180.71117127
84Phototransduction_Homo sapiens_hsa047440.70983885
85Glucagon signaling pathway_Homo sapiens_hsa049220.70750136
86Arginine biosynthesis_Homo sapiens_hsa002200.68060769
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67619435
88Type I diabetes mellitus_Homo sapiens_hsa049400.67286155
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66013005
90Alzheimers disease_Homo sapiens_hsa050100.65057683
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63204981
92Dilated cardiomyopathy_Homo sapiens_hsa054140.58517200
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56986423
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.56861155
95Prion diseases_Homo sapiens_hsa050200.56329117
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.56175445
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55657164
98Rap1 signaling pathway_Homo sapiens_hsa040150.55619175
99beta-Alanine metabolism_Homo sapiens_hsa004100.55103103
100Alcoholism_Homo sapiens_hsa050340.52759160
101Ras signaling pathway_Homo sapiens_hsa040140.51579857
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48702119
103African trypanosomiasis_Homo sapiens_hsa051430.48279265
104Wnt signaling pathway_Homo sapiens_hsa043100.46283823
105Oxidative phosphorylation_Homo sapiens_hsa001900.45920671
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43563554
107Non-small cell lung cancer_Homo sapiens_hsa052230.42930959
108T cell receptor signaling pathway_Homo sapiens_hsa046600.40845096
109Endocytosis_Homo sapiens_hsa041440.40043188
110Parkinsons disease_Homo sapiens_hsa050120.39728010
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39550561
112Linoleic acid metabolism_Homo sapiens_hsa005910.39440585
113Circadian rhythm_Homo sapiens_hsa047100.39029382
114Inositol phosphate metabolism_Homo sapiens_hsa005620.38543073
115Fatty acid elongation_Homo sapiens_hsa000620.38183788
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37303115
117Nitrogen metabolism_Homo sapiens_hsa009100.37258422
118Fatty acid metabolism_Homo sapiens_hsa012120.36142230
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35299318
120Metabolic pathways_Homo sapiens_hsa011000.35018540
121Bile secretion_Homo sapiens_hsa049760.34640790
122Renal cell carcinoma_Homo sapiens_hsa052110.34322325
123Arginine and proline metabolism_Homo sapiens_hsa003300.33903477
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33858454
125Chemical carcinogenesis_Homo sapiens_hsa052040.33240322
126Ether lipid metabolism_Homo sapiens_hsa005650.31917111
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31739043
128Huntingtons disease_Homo sapiens_hsa050160.30087223
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29674659
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29188945
131Chemokine signaling pathway_Homo sapiens_hsa040620.28771463
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.28431049
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28050028
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27522653
135Rheumatoid arthritis_Homo sapiens_hsa053230.26836893
136Endometrial cancer_Homo sapiens_hsa052130.25816592
137mTOR signaling pathway_Homo sapiens_hsa041500.25794512
138Salmonella infection_Homo sapiens_hsa051320.25345239
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23253718
140Ovarian steroidogenesis_Homo sapiens_hsa049130.21664526

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