EHBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.70809283
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.61673067
3cell communication by electrical coupling (GO:0010644)4.40904308
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.37700762
5cardiac myofibril assembly (GO:0055003)4.31549830
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.11051440
7peptidyl-glutamic acid carboxylation (GO:0017187)4.08526123
8protein carboxylation (GO:0018214)4.08526123
9negative regulation of fibrinolysis (GO:0051918)4.08398087
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.03463923
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.93155318
12negative regulation of potassium ion transmembrane transport (GO:1901380)3.87155979
13cell communication involved in cardiac conduction (GO:0086065)3.85764448
14regulation of fibrinolysis (GO:0051917)3.77319816
15plasma membrane repair (GO:0001778)3.73442705
16intestinal cholesterol absorption (GO:0030299)3.71373147
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70618139
18regulation of plasminogen activation (GO:0010755)3.69305104
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67848340
20very-low-density lipoprotein particle assembly (GO:0034379)3.63638608
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57174601
22layer formation in cerebral cortex (GO:0021819)3.55981963
23regulation of membrane repolarization (GO:0060306)3.54148259
24embryonic retina morphogenesis in camera-type eye (GO:0060059)3.50360109
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.47522170
26regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.45437128
27regulation of non-canonical Wnt signaling pathway (GO:2000050)3.43466560
28regulation of protein activation cascade (GO:2000257)3.42291757
29vocalization behavior (GO:0071625)3.41069092
30synaptic vesicle maturation (GO:0016188)3.39984626
31locomotory exploration behavior (GO:0035641)3.39858810
32negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36932740
33myofibril assembly (GO:0030239)3.36774802
34regulation of complement activation (GO:0030449)3.33663071
35sarcomere organization (GO:0045214)3.32425202
36cardiac muscle contraction (GO:0060048)3.27508070
37regulation of synapse structural plasticity (GO:0051823)3.26583062
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.23144964
39sodium ion export (GO:0071436)3.19793833
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.19376424
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.18469742
42neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16513910
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16362374
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11533917
45ventricular cardiac muscle cell action potential (GO:0086005)3.10700227
46plasma lipoprotein particle assembly (GO:0034377)3.09555201
47positive regulation of potassium ion transmembrane transport (GO:1901381)3.08823470
48cell migration in hindbrain (GO:0021535)3.07827401
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.04528441
50chondrocyte proliferation (GO:0035988)3.04388412
51establishment of nucleus localization (GO:0040023)3.02796065
52regulation of glutamate receptor signaling pathway (GO:1900449)2.97512439
53axonal fasciculation (GO:0007413)2.94822435
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94644310
55negative regulation of protein activation cascade (GO:2000258)2.93880915
56membrane depolarization during action potential (GO:0086010)2.92556576
57low-density lipoprotein particle remodeling (GO:0034374)2.92122663
58dendrite morphogenesis (GO:0048813)2.90050227
59synaptic vesicle exocytosis (GO:0016079)2.89822731
60regulation of cell communication by electrical coupling (GO:0010649)2.89292399
61protein localization to synapse (GO:0035418)2.87506776
62positive regulation of synapse maturation (GO:0090129)2.87501751
63cerebellar Purkinje cell differentiation (GO:0021702)2.87128595
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.86567703
65activation of protein kinase A activity (GO:0034199)2.86159580
66L-phenylalanine catabolic process (GO:0006559)2.85514038
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85514038
68cardiac conduction (GO:0061337)2.84801268
69detection of calcium ion (GO:0005513)2.83642812
70blood coagulation, intrinsic pathway (GO:0007597)2.83640639
71regulation of sarcomere organization (GO:0060297)2.82798196
72response to pheromone (GO:0019236)2.80191640
73cardiac muscle cell development (GO:0055013)2.80054655
74cardiac muscle hypertrophy (GO:0003300)2.78778130
75regulation of potassium ion transmembrane transporter activity (GO:1901016)2.77695203
76relaxation of cardiac muscle (GO:0055119)2.76766212
77positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76366354
78regulation of potassium ion transmembrane transport (GO:1901379)2.76273780
79exploration behavior (GO:0035640)2.75058781
80neuron recognition (GO:0008038)2.74951778
81regulation of calcium ion transmembrane transport (GO:1903169)2.74632984
82regulation of calcium ion transmembrane transporter activity (GO:1901019)2.74632984
83cardiac muscle cell action potential (GO:0086001)2.74256636
84protein-lipid complex remodeling (GO:0034368)2.74206862
85macromolecular complex remodeling (GO:0034367)2.74206862
86plasma lipoprotein particle remodeling (GO:0034369)2.74206862
87glutamate secretion (GO:0014047)2.73099433
88negative regulation of sodium ion transport (GO:0010766)2.73062939
89protein-lipid complex assembly (GO:0065005)2.72927783
90regulation of heart rate by cardiac conduction (GO:0086091)2.72649115
91COPII vesicle coating (GO:0048208)2.71984575
92innervation (GO:0060384)2.71111196
93striated muscle hypertrophy (GO:0014897)2.68198766
94cholesterol efflux (GO:0033344)2.67596082
95dendritic spine morphogenesis (GO:0060997)2.66728324
96cellular potassium ion homeostasis (GO:0030007)2.66294561
97regulation of synaptic vesicle exocytosis (GO:2000300)2.66140600
98neuron cell-cell adhesion (GO:0007158)2.64111968
99cardiac cell development (GO:0055006)2.63758146
100nucleus localization (GO:0051647)2.63584855
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62628946
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62572916
103L-phenylalanine metabolic process (GO:0006558)2.62572916
104cardiac muscle cell action potential involved in contraction (GO:0086002)2.62420421
105regulation of apoptotic cell clearance (GO:2000425)2.61657430
106regulation of actin filament-based movement (GO:1903115)2.61037710
107membrane repolarization during action potential (GO:0086011)2.60693546
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.58968824
109C4-dicarboxylate transport (GO:0015740)2.58908708
110membrane repolarization (GO:0086009)2.58102670
111proline transport (GO:0015824)2.56986457
112positive regulation of potassium ion transport (GO:0043268)2.56913385
113actomyosin structure organization (GO:0031032)2.54938357
114neurotransmitter secretion (GO:0007269)2.53606407
115plasma lipoprotein particle clearance (GO:0034381)2.52244408
116adult heart development (GO:0007512)2.51898752
117nephron epithelium morphogenesis (GO:0072088)2.51350706
118nephron tubule morphogenesis (GO:0072078)2.51350706
119high-density lipoprotein particle remodeling (GO:0034375)2.49735030
120central nervous system projection neuron axonogenesis (GO:0021952)2.48407523
121gamma-aminobutyric acid transport (GO:0015812)2.47985480
122regulation of relaxation of muscle (GO:1901077)2.47861807
123negative regulation of complement activation (GO:0045916)2.47159934
124regulation of the force of heart contraction (GO:0002026)2.47019560
125sarcoplasmic reticulum calcium ion transport (GO:0070296)2.46705693
126regulation of heart rate (GO:0002027)2.45588802
127regulation of synaptic vesicle transport (GO:1902803)2.44915205
128regulation of cardiac muscle contraction (GO:0055117)2.43138473
129potassium ion import (GO:0010107)2.42332322
130neurotransmitter-gated ion channel clustering (GO:0072578)2.42214463
131multicellular organismal signaling (GO:0035637)2.41650252
132reverse cholesterol transport (GO:0043691)2.41645181
133ionotropic glutamate receptor signaling pathway (GO:0035235)2.40469472
134axon extension (GO:0048675)2.40356554
135negative regulation of potassium ion transport (GO:0043267)2.40283240
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.40066850
137glutamate receptor signaling pathway (GO:0007215)2.39977500
138peptidyl-glutamic acid modification (GO:0018200)2.38085551
139negative regulation of lipase activity (GO:0060192)2.37248686
140regulation of cholesterol esterification (GO:0010872)2.36569320
141plasma lipoprotein particle organization (GO:0071827)2.36482978
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32234922
143peristalsis (GO:0030432)2.31931261
144paraxial mesoderm development (GO:0048339)2.31829375
145intestinal absorption (GO:0050892)2.30640340
146postsynaptic membrane organization (GO:0001941)2.27467229
147tonic smooth muscle contraction (GO:0014820)2.27009749
148regulation of bile acid biosynthetic process (GO:0070857)2.26830829
149low-density lipoprotein particle clearance (GO:0034383)2.25786672
150renal tubule morphogenesis (GO:0061333)2.24458027
151positive regulation of smoothened signaling pathway (GO:0045880)2.23407019
152positive regulation of glycolytic process (GO:0045821)2.22858545
153collagen fibril organization (GO:0030199)2.21670666
154positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.21146639
155protein-lipid complex subunit organization (GO:0071825)2.20933006
156fibrinolysis (GO:0042730)2.17878512
157regulation of dendritic spine morphogenesis (GO:0061001)2.17210754
158cell adhesion mediated by integrin (GO:0033627)2.14608709
159anterior/posterior axis specification, embryo (GO:0008595)2.10494018
160presynaptic membrane assembly (GO:0097105)2.07996621
161cell proliferation involved in metanephros development (GO:0072203)2.07994977
162negative regulation of astrocyte differentiation (GO:0048712)2.05624957
163regulation of phospholipase A2 activity (GO:0032429)2.04774742
164endocardial cushion development (GO:0003197)2.03356435
165positive regulation of neurological system process (GO:0031646)2.03118059
166negative regulation of wound healing (GO:0061045)2.02487509
167artery smooth muscle contraction (GO:0014824)2.02471790
168triglyceride homeostasis (GO:0070328)2.02444336
169acylglycerol homeostasis (GO:0055090)2.02444336
170positive regulation of dendritic spine development (GO:0060999)2.00576838
171lung epithelium development (GO:0060428)2.00229741
172glomerular visceral epithelial cell development (GO:0072015)2.00048185
173vascular smooth muscle contraction (GO:0014829)1.99740747
174positive regulation of hormone biosynthetic process (GO:0046886)1.99192087
175negative regulation of cholesterol transport (GO:0032375)1.98014555
176negative regulation of sterol transport (GO:0032372)1.98014555
177regulation of cholesterol homeostasis (GO:2000188)1.97219489
178neutral lipid catabolic process (GO:0046461)1.96005618
179acylglycerol catabolic process (GO:0046464)1.96005618
180negative regulation of hemostasis (GO:1900047)1.95662871
181negative regulation of blood coagulation (GO:0030195)1.95662871
182cell proliferation involved in kidney development (GO:0072111)1.95549747
183complement activation, alternative pathway (GO:0006957)1.95504537
184regulation of axon extension involved in axon guidance (GO:0048841)1.94972575
185positive regulation of extracellular matrix organization (GO:1903055)1.94405860
186positive regulation of cardiac muscle hypertrophy (GO:0010613)1.94319414
187positive regulation of muscle hypertrophy (GO:0014742)1.94319414
188skin morphogenesis (GO:0043589)1.94265235
189sterol transport (GO:0015918)1.93715739
190cholesterol transport (GO:0030301)1.93715739
191neuron projection extension involved in neuron projection guidance (GO:1902284)1.92477083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84196486
2GBX2_23144817_ChIP-Seq_PC3_Human2.90052264
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37355571
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27609617
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18453313
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18453313
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17637896
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15776775
9DROSHA_22980978_ChIP-Seq_HELA_Human2.13407914
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11361594
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.09567971
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09517803
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.04680115
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95333973
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93896442
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.92521257
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91344780
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89287863
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87377023
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.85248675
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.84965547
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82790775
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.75439488
24REST_21632747_ChIP-Seq_MESCs_Mouse1.72781565
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.70156013
26AR_21572438_ChIP-Seq_LNCaP_Human1.67221898
27SMAD4_21799915_ChIP-Seq_A2780_Human1.64656088
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62014402
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61863142
30TP53_18474530_ChIP-ChIP_U2OS_Human1.61806230
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.61609591
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60811741
33* CJUN_26792858_Chip-Seq_BT549_Human1.58520065
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.58375541
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57718362
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56913228
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53752192
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52771283
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50914756
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50467897
41FUS_26573619_Chip-Seq_HEK293_Human1.49326139
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48472397
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45660782
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.44483542
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43921178
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43195364
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43037525
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42846741
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42375572
50ZNF274_21170338_ChIP-Seq_K562_Hela1.40397299
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39564591
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39361481
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39308629
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39107568
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39107568
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.37106207
57IGF1R_20145208_ChIP-Seq_DFB_Human1.35004056
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.34788747
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34483678
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34346889
61AHR_22903824_ChIP-Seq_MCF-7_Human1.33746401
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.33621095
63* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33166714
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.32895110
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31794176
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31199250
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29998652
68* AR_19668381_ChIP-Seq_PC3_Human1.29680578
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.27495345
70* STAT3_23295773_ChIP-Seq_U87_Human1.27191548
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.27152151
72BRD4_25478319_ChIP-Seq_HGPS_Human1.27006297
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26830115
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.25487747
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25420843
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25279839
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.24552802
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23542012
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22571400
80* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21733337
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.21480250
82TP53_16413492_ChIP-PET_HCT116_Human1.20846094
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20843259
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.19698627
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19320680
86* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18753497
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.18024262
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17038886
89P300_19829295_ChIP-Seq_ESCs_Human1.16296468
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15876712
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14452319
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.14420413
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.13824054
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13660577
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13181346
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12893095
97AR_25329375_ChIP-Seq_VCAP_Human1.12662847
98* TCF4_23295773_ChIP-Seq_U87_Human1.12368525
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10428503
100SMAD4_21741376_ChIP-Seq_HESCs_Human1.10315457
101BCAT_22108803_ChIP-Seq_LS180_Human1.09968667
102TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09798884
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09533335
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08905870
105CBP_20019798_ChIP-Seq_JUKART_Human1.08870966
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08870966
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07864848
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07845355
109TAF15_26573619_Chip-Seq_HEK293_Human1.07588435
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07429655
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06255106
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06255106
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05329639
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04995027
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.04863975
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04610478
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04475662
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04473294
119* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04180112
120* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03649174
121RXR_22158963_ChIP-Seq_LIVER_Mouse1.03602909
122* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03323204
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.03234292
124AR_21909140_ChIP-Seq_LNCAP_Human1.02080592
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.01956303
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01693288
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01273907
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00899684
129SALL1_21062744_ChIP-ChIP_HESCs_Human1.00695941
130RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00086047
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.99779123
132KDM2B_26808549_Chip-Seq_K562_Human0.99536721
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99051314
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97816789
135* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97598529
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95436774
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95195298
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.95123776
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.95123776
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93554349
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.93527991
142RUNX2_22187159_ChIP-Seq_PCA_Human0.92125622
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90736081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.94793525
2MP0004859_abnormal_synaptic_plasticity3.62383632
3MP0000751_myopathy3.42261373
4MP0004084_abnormal_cardiac_muscle3.21247550
5MP0004215_abnormal_myocardial_fiber3.11815582
6MP0003646_muscle_fatigue2.65481386
7MP0004036_abnormal_muscle_relaxation2.35283317
8MP0000566_synostosis2.32294728
9MP0003635_abnormal_synaptic_transmissio2.29866557
10MP0004270_analgesia2.21900896
11MP0010368_abnormal_lymphatic_system2.14569488
12MP0004145_abnormal_muscle_electrophysio2.11221679
13MP0003137_abnormal_impulse_conducting2.07722112
14MP0003950_abnormal_plasma_membrane2.02829248
15MP0002139_abnormal_hepatobiliary_system1.97553026
16MP0003880_abnormal_central_pattern1.89745808
17MP0003868_abnormal_feces_composition1.86591944
18MP0002063_abnormal_learning/memory/cond1.82926926
19MP0003195_calcinosis1.82759033
20MP0009780_abnormal_chondrocyte_physiolo1.82242314
21MP0004233_abnormal_muscle_weight1.80266183
22MP0008775_abnormal_heart_ventricle1.77640077
23MP0005330_cardiomyopathy1.77056786
24MP0005360_urolithiasis1.74865989
25MP0002972_abnormal_cardiac_muscle1.72686260
26MP0004087_abnormal_muscle_fiber1.71375980
27MP0004085_abnormal_heartbeat1.69838131
28MP0009046_muscle_twitch1.68702300
29MP0005620_abnormal_muscle_contractility1.66496606
30MP0005257_abnormal_intraocular_pressure1.65328038
31MP0000749_muscle_degeneration1.64848010
32MP0004484_altered_response_of1.64446579
33MP0010329_abnormal_lipoprotein_level1.63503978
34MP0000778_abnormal_nervous_system1.62489558
35MP0000569_abnormal_digit_pigmentation1.60429857
36MP0009745_abnormal_behavioral_response1.59258090
37MP0005623_abnormal_meninges_morphology1.57748545
38MP0005423_abnormal_somatic_nervous1.56979477
39MP0003123_paternal_imprinting1.56292647
40MP0002734_abnormal_mechanical_nocicepti1.55631563
41MP0001666_abnormal_nutrient_absorption1.55312213
42MP0002938_white_spotting1.54073586
43MP0004130_abnormal_muscle_cell1.52583286
44MP0001968_abnormal_touch/_nociception1.52516297
45MP0006138_congestive_heart_failure1.48773257
46MP0005365_abnormal_bile_salt1.46760957
47MP0003941_abnormal_skin_development1.46095311
48MP0004858_abnormal_nervous_system1.45636572
49MP0008438_abnormal_cutaneous_collagen1.41209889
50MP0002572_abnormal_emotion/affect_behav1.40288154
51MP0002064_seizures1.39398286
52MP0003122_maternal_imprinting1.37633120
53MP0002909_abnormal_adrenal_gland1.37110659
54MP0003942_abnormal_urinary_system1.37085371
55MP0001486_abnormal_startle_reflex1.36660882
56MP0002234_abnormal_pharynx_morphology1.35207497
57MP0002184_abnormal_innervation1.33703748
58MP0010630_abnormal_cardiac_muscle1.32680714
59MP0005385_cardiovascular_system_phenoty1.31167668
60MP0001544_abnormal_cardiovascular_syste1.31167668
61MP0005503_abnormal_tendon_morphology1.30759415
62MP0006054_spinal_hemorrhage1.30608408
63MP0004885_abnormal_endolymph1.29199659
64MP0005670_abnormal_white_adipose1.27540529
65MP0002106_abnormal_muscle_physiology1.26974413
66MP0002735_abnormal_chemical_nociception1.26281830
67MP0003890_abnormal_embryonic-extraembry1.25317902
68MP0005085_abnormal_gallbladder_physiolo1.24955448
69MP0005187_abnormal_penis_morphology1.24839585
70MP0002269_muscular_atrophy1.24759324
71MP0003937_abnormal_limbs/digits/tail_de1.22957962
72MP0004924_abnormal_behavior1.21134327
73MP0005386_behavior/neurological_phenoty1.21134327
74MP0005408_hypopigmentation1.20733407
75MP0002272_abnormal_nervous_system1.20335897
76MP0001299_abnormal_eye_distance/1.19728584
77MP0005248_abnormal_Harderian_gland1.18987414
78MP0002067_abnormal_sensory_capabilities1.15917476
79MP0005369_muscle_phenotype1.15801273
80MP0003787_abnormal_imprinting1.14789813
81MP0002233_abnormal_nose_morphology1.13737686
82MP0003252_abnormal_bile_duct1.13628566
83MP0004811_abnormal_neuron_physiology1.13017111
84MP0001984_abnormal_olfaction1.11933643
85MP0003705_abnormal_hypodermis_morpholog1.10425019
86MP0000750_abnormal_muscle_regeneration1.09701653
87MP0001529_abnormal_vocalization1.08796664
88MP0002822_catalepsy1.08739401
89MP0002108_abnormal_muscle_morphology1.08506619
90MP0002653_abnormal_ependyma_morphology1.08378511
91MP0005646_abnormal_pituitary_gland1.06833396
92MP0005409_darkened_coat_color1.05902968
93MP0000955_abnormal_spinal_cord1.04275402
94MP0002295_abnormal_pulmonary_circulatio1.02899937
95MP0000759_abnormal_skeletal_muscle1.02579096
96MP0008569_lethality_at_weaning1.01876338
97MP0002733_abnormal_thermal_nociception1.01364621
98MP0000762_abnormal_tongue_morphology1.00530571
99MP0002127_abnormal_cardiovascular_syste1.00174278
100MP0006276_abnormal_autonomic_nervous1.00167068
101MP0009384_cardiac_valve_regurgitation1.00139823
102MP0009250_abnormal_appendicular_skeleto0.98980152
103MP0003755_abnormal_palate_morphology0.97199579
104MP0000747_muscle_weakness0.97159103
105MP0004510_myositis0.96937307
106MP0001440_abnormal_grooming_behavior0.96887542
107MP0001915_intracranial_hemorrhage0.96830327
108MP0002557_abnormal_social/conspecific_i0.96807114
109MP0005551_abnormal_eye_electrophysiolog0.96713181
110MP0002882_abnormal_neuron_morphology0.96002127
111MP0002282_abnormal_trachea_morphology0.94957990
112MP0009697_abnormal_copulation0.94436615
113MP0001970_abnormal_pain_threshold0.94410496
114MP0005410_abnormal_fertilization0.94315526
115MP0006072_abnormal_retinal_apoptosis0.93876260
116MP0000534_abnormal_ureter_morphology0.93629746
117MP0002736_abnormal_nociception_after0.93498122
118MP0008961_abnormal_basal_metabolism0.92799318
119MP0002089_abnormal_postnatal_growth/wei0.92688423
120MP0004272_abnormal_basement_membrane0.92280102
121MP0005275_abnormal_skin_tensile0.92023774
122MP0003115_abnormal_respiratory_system0.91214288
123MP0000003_abnormal_adipose_tissue0.89768999
124MP0003283_abnormal_digestive_organ0.89017868
125MP0003385_abnormal_body_wall0.88672348
126MP0001270_distended_abdomen0.88355989
127MP0001958_emphysema0.87748229
128MP0001177_atelectasis0.85597621
129MP0008875_abnormal_xenobiotic_pharmacok0.85449480
130MP0002971_abnormal_brown_adipose0.85010608
131MP0002152_abnormal_brain_morphology0.84101572
132MP0003566_abnormal_cell_adhesion0.83292890
133MP0000013_abnormal_adipose_tissue0.80815113
134MP0002896_abnormal_bone_mineralization0.79743989
135MP0010030_abnormal_orbit_morphology0.79325495
136MP0002066_abnormal_motor_capabilities/c0.77873463
137MP0003121_genomic_imprinting0.77746976
138MP0002697_abnormal_eye_size0.76259422
139MP0003045_fibrosis0.75517143
140MP0003315_abnormal_perineum_morphology0.74404911
141MP0000631_abnormal_neuroendocrine_gland0.73759219
142MP0009053_abnormal_anal_canal0.73580377
143MP0000639_abnormal_adrenal_gland0.73524606
144MP0001286_abnormal_eye_development0.73222280
145MP0000266_abnormal_heart_morphology0.71821261
146MP0003279_aneurysm0.71350264
147MP0001661_extended_life_span0.71272084
148MP0006292_abnormal_olfactory_placode0.71076752
149MP0002116_abnormal_craniofacial_bone0.70514809
150MP0000163_abnormal_cartilage_morphology0.69991111
151MP0002115_abnormal_skeleton_extremities0.69681178
152MP0002109_abnormal_limb_morphology0.69011870
153MP0001502_abnormal_circadian_rhythm0.67552838
154MP0000049_abnormal_middle_ear0.66777907
155MP0002160_abnormal_reproductive_system0.66314358
156MP0003861_abnormal_nervous_system0.66099877
157MP0004134_abnormal_chest_morphology0.65777798
158MP0000432_abnormal_head_morphology0.65552338
159MP0002876_abnormal_thyroid_physiology0.65492508
160MP0003633_abnormal_nervous_system0.64874548
161MP0003935_abnormal_craniofacial_develop0.64448847
162MP0000428_abnormal_craniofacial_morphol0.64385042

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.28198886
2Sudden death (HP:0001699)4.81960720
3Prolonged partial thromboplastin time (HP:0003645)4.31442778
4Atrial fibrillation (HP:0005110)3.95757546
5Primary atrial arrhythmia (HP:0001692)3.78486831
6Supraventricular tachycardia (HP:0004755)3.54730281
7Supraventricular arrhythmia (HP:0005115)3.51374356
8Prolonged QT interval (HP:0001657)3.49662399
9Bundle branch block (HP:0011710)3.48915047
10Syncope (HP:0001279)3.44640711
11Hypobetalipoproteinemia (HP:0003563)3.28699702
12Abnormality of the calf musculature (HP:0001430)3.27818416
13Small epiphyses (HP:0010585)3.07964372
14Ventricular fibrillation (HP:0001663)3.06041201
15Vascular tortuosity (HP:0004948)3.01889494
16Ventricular tachycardia (HP:0004756)2.99695783
17Exercise-induced myalgia (HP:0003738)2.96731944
18Focal motor seizures (HP:0011153)2.92559769
19Calf muscle hypertrophy (HP:0008981)2.91324299
20Abnormality of carpal bone ossification (HP:0006257)2.89221610
21Arterial tortuosity (HP:0005116)2.86129074
22Complement deficiency (HP:0004431)2.83424086
23Action tremor (HP:0002345)2.79804558
24Myokymia (HP:0002411)2.78307598
25Ventricular arrhythmia (HP:0004308)2.74573663
26Cardiovascular calcification (HP:0011915)2.74178320
27Premature rupture of membranes (HP:0001788)2.73950416
28Abnormality of the common coagulation pathway (HP:0010990)2.73032707
29Focal seizures (HP:0007359)2.70952546
30Neonatal short-limb short stature (HP:0008921)2.65886094
31Hyporeflexia of lower limbs (HP:0002600)2.65422778
32Abnormal EKG (HP:0003115)2.64964229
33Broad palm (HP:0001169)2.64870953
34Aortic dissection (HP:0002647)2.61380651
35Aortic aneurysm (HP:0004942)2.61259520
36Muscle hypertrophy of the lower extremities (HP:0008968)2.61154855
37Termporal pattern (HP:0011008)2.59805910
38Insidious onset (HP:0003587)2.59805910
39Lipoatrophy (HP:0100578)2.57352060
40Vascular calcification (HP:0004934)2.55146885
41Abnormality of the left ventricular outflow tract (HP:0011103)2.52550500
42Subaortic stenosis (HP:0001682)2.52550500
43Central scotoma (HP:0000603)2.52279005
44Progressive cerebellar ataxia (HP:0002073)2.51785402
45Right ventricular cardiomyopathy (HP:0011663)2.51784265
46Dysmetric saccades (HP:0000641)2.51709862
47Exercise-induced muscle cramps (HP:0003710)2.49641898
48Joint hemorrhage (HP:0005261)2.49127773
49Muscle fiber splitting (HP:0003555)2.48946832
50Broad metatarsal (HP:0001783)2.48743154
51Abnormal hand bone ossification (HP:0010660)2.46204172
52Arthropathy (HP:0003040)2.45159070
53Conjugated hyperbilirubinemia (HP:0002908)2.44016511
54Mitral stenosis (HP:0001718)2.40544471
55Genetic anticipation (HP:0003743)2.35908633
56Heart block (HP:0012722)2.35228741
57Hypolipoproteinemia (HP:0010981)2.35123777
58Epidermoid cyst (HP:0200040)2.33150105
59Alacrima (HP:0000522)2.32485184
60Hypercholesterolemia (HP:0003124)2.29632918
61Visual hallucinations (HP:0002367)2.29198146
62Coronal craniosynostosis (HP:0004440)2.28003795
63Febrile seizures (HP:0002373)2.26121365
64Epileptic encephalopathy (HP:0200134)2.26007267
65Broad alveolar ridges (HP:0000187)2.23501330
66Difficulty running (HP:0009046)2.21704554
67Spontaneous abortion (HP:0005268)2.19923386
68Abnormality of the lower motor neuron (HP:0002366)2.19674428
69Abnormal atrioventricular conduction (HP:0005150)2.18514861
70Abnormality of the nasal septum (HP:0000419)2.18401663
71Soft skin (HP:0000977)2.16002888
72Shallow orbits (HP:0000586)2.14210891
73Decreased lacrimation (HP:0000633)2.13498808
74Myotonia (HP:0002486)2.13394063
75Abnormal ossification of hand bones (HP:0005921)2.12232816
76Abnormality of dentin (HP:0010299)2.11701144
77Epiphyseal dysplasia (HP:0002656)2.10877218
78Pheochromocytoma (HP:0002666)2.08450604
79Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07108226
80Increased variability in muscle fiber diameter (HP:0003557)2.06155707
81Left ventricular hypertrophy (HP:0001712)2.05701727
82Abnormality of the wing of the ilium (HP:0011867)2.04892270
83Atrioventricular block (HP:0001678)2.01535254
84Microglossia (HP:0000171)2.00563606
85Lymphangioma (HP:0100764)1.99040548
86Pancreatic islet-cell hyperplasia (HP:0004510)1.98542242
87Asymmetric septal hypertrophy (HP:0001670)1.97346136
88Increased connective tissue (HP:0009025)1.97321090
89Abnormality of complement system (HP:0005339)1.96596240
90Papillary thyroid carcinoma (HP:0002895)1.96542929
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96381865
92Lower limb amyotrophy (HP:0007210)1.95433699
93Excessive salivation (HP:0003781)1.93278014
94Drooling (HP:0002307)1.93278014
95Renal duplication (HP:0000075)1.93081711
96EMG: myopathic abnormalities (HP:0003458)1.92866306
97Buphthalmos (HP:0000557)1.91359406
98Broad-based gait (HP:0002136)1.91177000
99Limited elbow extension (HP:0001377)1.90505470
100Hypophosphatemic rickets (HP:0004912)1.88614445
101Urinary bladder sphincter dysfunction (HP:0002839)1.88237911
102Abnormal tarsal ossification (HP:0008369)1.87599098
103Rhizomelia (HP:0008905)1.86927297
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86549736
105Dysdiadochokinesis (HP:0002075)1.85357366
106Supernumerary spleens (HP:0009799)1.85175696
107Dilated cardiomyopathy (HP:0001644)1.84958133
108Bladder diverticulum (HP:0000015)1.83360244
109Overgrowth (HP:0001548)1.82226282
110Renovascular hypertension (HP:0100817)1.81858321
111Palpitations (HP:0001962)1.81271715
112Hypothermia (HP:0002045)1.81052811
113Abnormality of the acetabulum (HP:0003170)1.80899033
114Abnormal delivery (HP:0001787)1.80782062
115Scotoma (HP:0000575)1.79931401
116Absence seizures (HP:0002121)1.79184717
117Atonic seizures (HP:0010819)1.79117786
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78526068
119Neoplasm of the heart (HP:0100544)1.78255789
120Intrahepatic cholestasis (HP:0001406)1.77523943
121Follicular hyperkeratosis (HP:0007502)1.77310338
122Abnormality of the intrinsic pathway (HP:0010989)1.77015932
123Menorrhagia (HP:0000132)1.76969288
124Xanthomatosis (HP:0000991)1.76953508
125Protrusio acetabuli (HP:0003179)1.76377783
126Wide anterior fontanel (HP:0000260)1.76027935
127Hamartoma of the eye (HP:0010568)1.75875948
128Enlarged kidneys (HP:0000105)1.74931542
129Ulnar claw (HP:0001178)1.74350754
130Flared iliac wings (HP:0002869)1.73349299
131Hypoventilation (HP:0002791)1.73339986
132Impaired vibration sensation in the lower limbs (HP:0002166)1.73082864
133Cerebral aneurysm (HP:0004944)1.72114628
134Depression (HP:0000716)1.71834428
135Hypoplastic ischia (HP:0003175)1.71770644
136Atrophic scars (HP:0001075)1.71528861
137Acanthocytosis (HP:0001927)1.69823177
138Generalized tonic-clonic seizures (HP:0002069)1.69461629
139Midline defect of the nose (HP:0004122)1.69197760
140Glomerulonephritis (HP:0000099)1.68486894
141Irregular epiphyses (HP:0010582)1.68061064
142Neuroendocrine neoplasm (HP:0100634)1.68054657
143Hypoalphalipoproteinemia (HP:0003233)1.67593098
144Myoglobinuria (HP:0002913)1.67576004
145Abnormality of the 4th metacarpal (HP:0010012)1.67377530
146Wide nose (HP:0000445)1.65886160
147Limited hip movement (HP:0008800)1.65739579
148Elfin facies (HP:0004428)1.65310868
149Mildly elevated creatine phosphokinase (HP:0008180)1.65127224
150Gaze-evoked nystagmus (HP:0000640)1.63644833
151Torticollis (HP:0000473)1.63217450
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63091855
153Absent epiphyses (HP:0010577)1.63091855
154Bradycardia (HP:0001662)1.62982938
155Abnormal social behavior (HP:0012433)1.62560924
156Impaired social interactions (HP:0000735)1.62560924
157Hepatoblastoma (HP:0002884)1.62040975
158Wormian bones (HP:0002645)1.61953880
159Poor eye contact (HP:0000817)1.61912330
160Type 1 muscle fiber predominance (HP:0003803)1.61424428
161Hammertoe (HP:0001765)1.61117591
162Postural instability (HP:0002172)1.60665079
163Flat cornea (HP:0007720)1.59281103
164Abnormality of skeletal muscle fiber size (HP:0012084)1.59082074
165Ankle contracture (HP:0006466)1.57947384
166Skin nodule (HP:0200036)1.57599896
167Hypoglycemic coma (HP:0001325)1.57124273
168Enlarged penis (HP:0000040)1.57056787
169Abnormality of the foot musculature (HP:0001436)1.56239160
170Macroorchidism (HP:0000053)1.55727839
171Prominent supraorbital ridges (HP:0000336)1.55397618
172Advanced eruption of teeth (HP:0006288)1.54840615
173Pointed chin (HP:0000307)1.53833082
174Neonatal death (HP:0003811)1.53262029
175Heterotopia (HP:0002282)1.53024158
176Abnormality of the pubic bones (HP:0003172)1.52927883
177Overlapping toe (HP:0001845)1.52575613
178Morphological abnormality of the middle ear (HP:0008609)1.51057454
179Coxa vara (HP:0002812)1.49438521
180Asymmetry of the thorax (HP:0001555)1.49122242
181Facial shape deformation (HP:0011334)1.48340040
182Potter facies (HP:0002009)1.48340040
183Cervical subluxation (HP:0003308)1.47728840
184Impaired pain sensation (HP:0007328)1.46973643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.09224688
2AKT32.78081637
3NTRK32.67240042
4MAP3K42.63369880
5PHKG12.57024689
6PHKG22.57024689
7LMTK22.34827200
8PDK32.25529306
9PDK42.25529306
10EPHA42.15569573
11PAK62.03296204
12MAP3K92.02480506
13PRKD32.01377110
14BCR2.00512277
15TTN2.00219061
16LATS21.99349061
17FGFR31.98101526
18LATS11.83584906
19DMPK1.73858383
20PKN21.73375660
21MET1.65399032
22MINK11.62011032
23TRIB31.58051423
24PAK31.53872575
25FGFR41.51611909
26CAMKK11.50607793
27KSR11.50532386
28MAP2K71.50103122
29RIPK11.49999379
30STK381.47183474
31WNK31.45203767
32NEK11.41989600
33MST1R1.41632069
34CAMK1G1.41098156
35MAP2K41.36898514
36KSR21.35619169
37MAPK131.30946942
38PDGFRA1.30731279
39NTRK21.30379737
40DDR21.25996367
41DAPK21.25964323
42STK391.21955469
43INSRR1.21715171
44BMPR1B1.19007028
45RET1.17635903
46FRK1.16302910
47FER1.08529179
48TRIM281.08466883
49OBSCN1.07105093
50CDK121.06115785
51STK31.05457045
52MAP3K121.04651393
53CDC42BPA1.02964034
54PTK21.02274214
55BRD41.01299964
56PDK21.00261772
57PINK10.96665818
58ERBB40.96248072
59ROCK10.96092587
60PLK20.94834029
61CAMK1D0.92866705
62ICK0.91772071
63CDK50.91449178
64TAOK10.91064725
65MYLK0.90665229
66SIK10.89924063
67SGK20.89786173
68SIK20.89132356
69PAK20.87616103
70TYRO30.87602563
71CAMK2A0.85978744
72NTRK10.85314719
73PIK3CA0.85266103
74SGK30.85141320
75CASK0.85095789
76EPHA30.83196983
77PRKAA10.82417428
78PLK40.82257526
79WNK10.80778317
80PTK2B0.80475355
81NEK90.79622726
82ERBB30.78929931
83CSNK1A1L0.78583917
84TGFBR20.76435190
85PNCK0.76282080
86SGK4940.76123081
87SGK2230.76123081
88MARK20.76101194
89CAMK2D0.75242212
90EPHB20.74154872
91CSNK1G10.73265701
92CAMK40.72769510
93MAP3K70.72724812
94FGFR20.70210565
95CSNK1E0.70184819
96MAP3K60.70167697
97FLT30.68854066
98UHMK10.66847866
99STK110.66688140
100PRKCG0.65502806
101CAMK10.65364419
102PRKD10.64649252
103CDK30.63694918
104PRKCH0.62534118
105MAP4K20.61946969
106PRKCE0.61540873
107STK38L0.60095159
108EIF2AK10.58618148
109SGK10.58213274
110RPS6KA20.58094249
111MAP3K20.57276294
112PLK30.54198306
113BRSK20.54136832
114CSNK1G20.53061719
115TNIK0.52647374
116PRKAA20.51958652
117NEK20.51954604
118GRK50.51769431
119RPS6KA30.50999270
120CDK80.49836872
121STK240.49587863
122PRKG10.48452530
123WNK40.48191132
124PRKCZ0.47414375
125CAMKK20.46973739
126PDGFRB0.46581200
127PKN10.46145300
128ROCK20.45886416
129NUAK10.45654312
130ERBB20.44587312
131BRSK10.44314635
132EIF2AK30.43767815
133CSNK1D0.43693287
134FGFR10.43566488
135MAPKAPK50.42911794
136MKNK20.40074096
137MTOR0.39762784
138DYRK1A0.39557039
139CDK180.39321062
140MUSK0.38462116
141PDK10.38345184
142PRKACB0.38197209

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.03401445
2Dilated cardiomyopathy_Homo sapiens_hsa054142.41070493
3Nicotine addiction_Homo sapiens_hsa050332.17354402
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12928969
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.10488365
6Circadian entrainment_Homo sapiens_hsa047132.09340064
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08995692
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02446991
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91248218
10Cardiac muscle contraction_Homo sapiens_hsa042601.90505173
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90081558
12Olfactory transduction_Homo sapiens_hsa047401.84260918
13Synaptic vesicle cycle_Homo sapiens_hsa047211.82034137
14GABAergic synapse_Homo sapiens_hsa047271.81768054
15Insulin secretion_Homo sapiens_hsa049111.81347833
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72888297
17Steroid biosynthesis_Homo sapiens_hsa001001.72435668
18Long-term potentiation_Homo sapiens_hsa047201.72407799
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72049306
20Glutamatergic synapse_Homo sapiens_hsa047241.70871734
21Morphine addiction_Homo sapiens_hsa050321.60798967
22Amphetamine addiction_Homo sapiens_hsa050311.58538368
23Type II diabetes mellitus_Homo sapiens_hsa049301.57492906
24Dopaminergic synapse_Homo sapiens_hsa047281.55397584
25Vitamin B6 metabolism_Homo sapiens_hsa007501.54549335
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53456039
27PPAR signaling pathway_Homo sapiens_hsa033201.53130082
28Oxytocin signaling pathway_Homo sapiens_hsa049211.49090230
29Cholinergic synapse_Homo sapiens_hsa047251.48126747
30Fat digestion and absorption_Homo sapiens_hsa049751.47740498
31Renin secretion_Homo sapiens_hsa049241.44018388
32Salivary secretion_Homo sapiens_hsa049701.43776931
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.38867104
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38315776
35Gastric acid secretion_Homo sapiens_hsa049711.37985058
36Histidine metabolism_Homo sapiens_hsa003401.35895096
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.35230690
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34662193
39Calcium signaling pathway_Homo sapiens_hsa040201.34261005
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29957045
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27692962
42Taste transduction_Homo sapiens_hsa047421.27579051
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27169946
44GnRH signaling pathway_Homo sapiens_hsa049121.25442320
45Retinol metabolism_Homo sapiens_hsa008301.25436847
46Arginine biosynthesis_Homo sapiens_hsa002201.24695148
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24043714
48Phenylalanine metabolism_Homo sapiens_hsa003601.23768953
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23664186
50cAMP signaling pathway_Homo sapiens_hsa040241.22444754
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22419842
52Gap junction_Homo sapiens_hsa045401.21706531
53Axon guidance_Homo sapiens_hsa043601.18953307
54Glucagon signaling pathway_Homo sapiens_hsa049221.15962866
55Dorso-ventral axis formation_Homo sapiens_hsa043201.13757109
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12644936
57Estrogen signaling pathway_Homo sapiens_hsa049151.11346022
58Tyrosine metabolism_Homo sapiens_hsa003501.09790699
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09422788
60Cocaine addiction_Homo sapiens_hsa050301.08998774
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.08226559
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08142161
63Glioma_Homo sapiens_hsa052141.07081019
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05011249
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03637006
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03270533
67mTOR signaling pathway_Homo sapiens_hsa041501.01820705
68Nitrogen metabolism_Homo sapiens_hsa009101.01470870
69Long-term depression_Homo sapiens_hsa047301.01232793
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01078833
71Chemical carcinogenesis_Homo sapiens_hsa052041.00288748
72Starch and sucrose metabolism_Homo sapiens_hsa005000.99832827
73Melanogenesis_Homo sapiens_hsa049160.99194347
74Serotonergic synapse_Homo sapiens_hsa047260.98521776
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.96297565
76Insulin signaling pathway_Homo sapiens_hsa049100.93788911
77Endometrial cancer_Homo sapiens_hsa052130.93438339
78ABC transporters_Homo sapiens_hsa020100.92894307
79Protein digestion and absorption_Homo sapiens_hsa049740.92789322
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91685096
81Pyruvate metabolism_Homo sapiens_hsa006200.91216076
82Circadian rhythm_Homo sapiens_hsa047100.90817170
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90255522
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89551573
85ErbB signaling pathway_Homo sapiens_hsa040120.88774567
86Glycerolipid metabolism_Homo sapiens_hsa005610.86157970
87TGF-beta signaling pathway_Homo sapiens_hsa043500.84960319
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84867956
89beta-Alanine metabolism_Homo sapiens_hsa004100.83975379
90Focal adhesion_Homo sapiens_hsa045100.83379402
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81014846
92Vitamin digestion and absorption_Homo sapiens_hsa049770.80314422
93Propanoate metabolism_Homo sapiens_hsa006400.79519396
94Arginine and proline metabolism_Homo sapiens_hsa003300.79344971
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78280807
96N-Glycan biosynthesis_Homo sapiens_hsa005100.77751337
97Hedgehog signaling pathway_Homo sapiens_hsa043400.77592391
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.77254680
99Oocyte meiosis_Homo sapiens_hsa041140.76702439
100Ovarian steroidogenesis_Homo sapiens_hsa049130.75047605
101Insulin resistance_Homo sapiens_hsa049310.73531718
102AMPK signaling pathway_Homo sapiens_hsa041520.72065864
103Fatty acid elongation_Homo sapiens_hsa000620.71493651
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71390743
105Adherens junction_Homo sapiens_hsa045200.70075812
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67130137
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.67016774
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65219689
109Bile secretion_Homo sapiens_hsa049760.65018730
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65016842
111Tryptophan metabolism_Homo sapiens_hsa003800.64845424
112Phototransduction_Homo sapiens_hsa047440.64745297
113ECM-receptor interaction_Homo sapiens_hsa045120.64710608
114Viral myocarditis_Homo sapiens_hsa054160.63983797
115Wnt signaling pathway_Homo sapiens_hsa043100.63813754
116Lysine degradation_Homo sapiens_hsa003100.63807351
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63482753
118Tight junction_Homo sapiens_hsa045300.63327540
119Hippo signaling pathway_Homo sapiens_hsa043900.62820158
120Butanoate metabolism_Homo sapiens_hsa006500.62495356
121Choline metabolism in cancer_Homo sapiens_hsa052310.62063390
122Fatty acid metabolism_Homo sapiens_hsa012120.61981787
123Renal cell carcinoma_Homo sapiens_hsa052110.61931631
124Thyroid hormone synthesis_Homo sapiens_hsa049180.60216891
125Fatty acid degradation_Homo sapiens_hsa000710.59867486
126Peroxisome_Homo sapiens_hsa041460.59284188
127MAPK signaling pathway_Homo sapiens_hsa040100.58730704
128Basal cell carcinoma_Homo sapiens_hsa052170.58397910
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58364429
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57912078
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57799585
132Fatty acid biosynthesis_Homo sapiens_hsa000610.56776087
133Rap1 signaling pathway_Homo sapiens_hsa040150.55134315
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54657127
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54604001
136Proteoglycans in cancer_Homo sapiens_hsa052050.54378917
137VEGF signaling pathway_Homo sapiens_hsa043700.52708881
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52367928
139Pancreatic secretion_Homo sapiens_hsa049720.52159423
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.51888059
141Ras signaling pathway_Homo sapiens_hsa040140.50671689
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49987489
143Melanoma_Homo sapiens_hsa052180.49218065
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48898763
145Protein export_Homo sapiens_hsa030600.48727295
146Amoebiasis_Homo sapiens_hsa051460.47417818
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.44965020
148Renin-angiotensin system_Homo sapiens_hsa046140.42927042

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