EHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.70361411
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.70361411
3modulation by symbiont of host immune response (GO:0052553)4.70361411
4positive regulation by symbiont of host defense response (GO:0052509)4.70361411
5modulation by symbiont of host defense response (GO:0052031)4.70361411
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.70361411
7response to peptidoglycan (GO:0032494)4.40880816
8regulation of vitamin D biosynthetic process (GO:0060556)4.40240079
9negative regulation of cell killing (GO:0031342)4.23712743
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23712743
11regulation of podosome assembly (GO:0071801)4.11203482
12regulation of dendritic cell antigen processing and presentation (GO:0002604)3.99550559
13regulation of integrin activation (GO:0033623)3.97588475
14response to muramyl dipeptide (GO:0032495)3.89377211
15positive regulation of chemokine biosynthetic process (GO:0045080)3.85853450
16neutrophil activation involved in immune response (GO:0002283)3.85111956
17germinal center formation (GO:0002467)3.84840909
18negative regulation of interleukin-12 production (GO:0032695)3.74144359
19positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.62899498
20NIK/NF-kappaB signaling (GO:0038061)3.60689045
21wound healing, spreading of epidermal cells (GO:0035313)3.59490934
22myeloid dendritic cell differentiation (GO:0043011)3.59292275
23cell adhesion mediated by integrin (GO:0033627)3.58079525
24regulation of cytokine secretion involved in immune response (GO:0002739)3.58053110
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56886002
26positive regulation of interferon-alpha production (GO:0032727)3.53316677
27response to protozoan (GO:0001562)3.48817083
28regulation of vitamin metabolic process (GO:0030656)3.48770078
29defense response to protozoan (GO:0042832)3.47926493
30apoptotic cell clearance (GO:0043277)3.45692357
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43584084
32regulation of interferon-alpha production (GO:0032647)3.42733997
33natural killer cell mediated immunity (GO:0002228)3.42617447
34natural killer cell mediated cytotoxicity (GO:0042267)3.42617447
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38371186
36T-helper 1 type immune response (GO:0042088)3.35456626
37regulation of chronic inflammatory response (GO:0002676)3.34884117
38* low-density lipoprotein particle clearance (GO:0034383)3.30027424
39macrophage activation involved in immune response (GO:0002281)3.29841765
40regulation of T-helper 2 cell differentiation (GO:0045628)3.28377666
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.22804687
42immunoglobulin mediated immune response (GO:0016064)3.22470535
43detection of other organism (GO:0098543)3.19350919
44positive regulation of p38MAPK cascade (GO:1900745)3.13778902
45myeloid dendritic cell activation (GO:0001773)3.12917167
46regulation of membrane protein ectodomain proteolysis (GO:0051043)3.09074354
47regulation of T-helper 1 cell differentiation (GO:0045625)3.08805744
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08246164
49detection of bacterium (GO:0016045)3.07429274
50positive regulation of heat generation (GO:0031652)3.05591476
51respiratory burst (GO:0045730)3.05289465
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05031970
53positive regulation of type 2 immune response (GO:0002830)3.02110105
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00238613
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00153259
56regulation of interferon-beta biosynthetic process (GO:0045357)2.97662296
57hydrogen peroxide biosynthetic process (GO:0050665)2.96131427
58regulation of mononuclear cell migration (GO:0071675)2.95412217
59regulation of gamma-delta T cell activation (GO:0046643)2.93641309
60response to host immune response (GO:0052572)2.92737983
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92737983
62cytokine secretion (GO:0050663)2.91659515
63positive regulation of NF-kappaB import into nucleus (GO:0042346)2.91337815
64negative regulation of erythrocyte differentiation (GO:0045647)2.89608010
65positive regulation of antigen processing and presentation (GO:0002579)2.88058524
66antigen processing and presentation of endogenous antigen (GO:0019883)2.87711324
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86318889
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86318889
69leukocyte aggregation (GO:0070486)2.85497472
70granulocyte activation (GO:0036230)2.82428821
71cellular response to lipopolysaccharide (GO:0071222)2.81462004
72myeloid cell activation involved in immune response (GO:0002275)2.81446221
73T cell migration (GO:0072678)2.79950743
74negative regulation of nitric oxide biosynthetic process (GO:0045019)2.78882919
75regulation of type 2 immune response (GO:0002828)2.78457398
76regulation of chemokine biosynthetic process (GO:0045073)2.78256201
77leukocyte cell-cell adhesion (GO:0007159)2.77924110
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77919322
79dendritic cell differentiation (GO:0097028)2.77822294
80regulation of interleukin-12 production (GO:0032655)2.75573769
81positive regulation of interferon-beta production (GO:0032728)2.75522803
82cellular response to molecule of bacterial origin (GO:0071219)2.75436265
83negative regulation of production of molecular mediator of immune response (GO:0002701)2.75341024
84modulation by symbiont of host cellular process (GO:0044068)2.74758116
85detection of external biotic stimulus (GO:0098581)2.74504607
86negative regulation of myeloid cell apoptotic process (GO:0033033)2.74178098
87apoptotic process involved in morphogenesis (GO:0060561)2.71488288
88cellular response to virus (GO:0098586)2.71281282
89cellular extravasation (GO:0045123)2.70199731
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70044176
91response to host (GO:0075136)2.70044176
92response to host defenses (GO:0052200)2.70044176
93negative regulation of T cell mediated immunity (GO:0002710)2.69441856
94wound healing, spreading of cells (GO:0044319)2.69269964
95regulation of macrophage cytokine production (GO:0010935)2.68852793
96CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68410279
97positive regulation of leukocyte degranulation (GO:0043302)2.68125338
98mature B cell differentiation involved in immune response (GO:0002313)2.67783438
99endodermal cell differentiation (GO:0035987)2.66590673
100regulation of T cell tolerance induction (GO:0002664)2.65876972
101negative regulation of cytokine production involved in immune response (GO:0002719)2.65367042
102regulation of fever generation (GO:0031620)2.65181921
103cellular response to interferon-gamma (GO:0071346)2.65066337
104response to laminar fluid shear stress (GO:0034616)2.64779355
105protein localization to endosome (GO:0036010)2.64368192
106positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63002520
107detection of molecule of bacterial origin (GO:0032490)2.62664814
108branching involved in labyrinthine layer morphogenesis (GO:0060670)2.62603444
109B cell mediated immunity (GO:0019724)2.61964146
110myeloid cell homeostasis (GO:0002262)2.60971248
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60854348
112negative regulation of interleukin-6 production (GO:0032715)2.60550707
113regulation of antigen processing and presentation (GO:0002577)2.59928420
114positive regulation of interleukin-12 production (GO:0032735)2.59687516
115positive regulation of natural killer cell differentiation (GO:0032825)2.58929596
116regulation of interleukin-2 biosynthetic process (GO:0045076)2.58513289
117regulation of interleukin-6 production (GO:0032675)2.57792818
118macrophage activation (GO:0042116)2.57690430
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.56743273
120regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.56425608
121neutrophil activation (GO:0042119)2.56085904
122* regulation of cholesterol storage (GO:0010885)2.56031670
123positive regulation of interleukin-6 production (GO:0032755)2.55959060
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53072953
125positive regulation of macrophage cytokine production (GO:0060907)2.52762793
126leukocyte mediated cytotoxicity (GO:0001909)2.51470424
127morphogenesis of an endothelium (GO:0003159)2.50544916
128endothelial tube morphogenesis (GO:0061154)2.50544916
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49803631
130interferon-gamma secretion (GO:0072643)2.48606493
131regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48046380
132positive regulation of gamma-delta T cell activation (GO:0046645)2.47673029
133regulation of heterotypic cell-cell adhesion (GO:0034114)2.46202269
134positive regulation of mast cell degranulation (GO:0043306)2.46183281
135positive regulation of mast cell activation involved in immune response (GO:0033008)2.46183281
136virion attachment to host cell (GO:0019062)2.43548649
137adhesion of symbiont to host cell (GO:0044650)2.43548649
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43429653
139reactive oxygen species biosynthetic process (GO:1903409)2.42549882
140negative regulation of lipid storage (GO:0010888)2.41608036
141type I interferon signaling pathway (GO:0060337)2.41599262
142cellular response to type I interferon (GO:0071357)2.41599262
143response to type I interferon (GO:0034340)2.41427791
144I-kappaB phosphorylation (GO:0007252)2.41385409
145interferon-gamma-mediated signaling pathway (GO:0060333)2.41330982
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41080835
147positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.40286567
148positive regulation of protein oligomerization (GO:0032461)2.39853536
149cellular response to interferon-alpha (GO:0035457)2.38841652
150activation of MAPKKK activity (GO:0000185)2.38153591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse3.75741845
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37045220
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.34619649
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.33065056
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.28523767
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.19914619
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.77824650
8* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54417546
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48341763
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45003657
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42552028
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41631807
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26879754
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25264520
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20580060
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11965744
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11803122
18* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03552049
19VDR_21846776_ChIP-Seq_THP-1_Human1.93247424
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.88653651
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87011455
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84692445
23* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84214349
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72569694
25RUNX_20019798_ChIP-Seq_JUKART_Human1.70247153
26MAF_26560356_Chip-Seq_TH1_Human1.68053419
27MYC_22102868_ChIP-Seq_BL_Human1.67951095
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65746507
29* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64354755
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62223311
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60824044
32* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57699465
33* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57194461
34KDM2B_26808549_Chip-Seq_DND41_Human1.56146700
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55186159
36VDR_24763502_ChIP-Seq_THP-1_Human1.54600067
37TCF7_22412390_ChIP-Seq_EML_Mouse1.54254163
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54013927
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54011830
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52357591
41SCL_19346495_ChIP-Seq_HPC-7_Human1.52317912
42* LXR_22292898_ChIP-Seq_THP-1_Human1.51610804
43CLOCK_20551151_ChIP-Seq_293T_Human1.49411468
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48828248
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48483729
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47836041
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46342546
48VDR_24787735_ChIP-Seq_THP-1_Human1.45874614
49ATF3_27146783_Chip-Seq_COLON_Human1.45391809
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44889368
51* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43916919
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.42650024
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40297296
54* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40174889
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.38230478
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.37868706
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.37757906
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31907195
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31359557
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31102004
61* GATA1_19941827_ChIP-Seq_MEL_Mouse1.29958444
62UTX_26944678_Chip-Seq_JUKART_Human1.29628995
63* SPI1_23547873_ChIP-Seq_NB4_Human1.29512667
64* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29379804
65* SPI1_23127762_ChIP-Seq_K562_Human1.29349898
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29116539
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27623342
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25879703
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24803736
70* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24464157
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24255674
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23557926
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22215656
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20859157
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20121246
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19550500
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19381606
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18409983
79* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18155402
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17450113
81* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16040456
82* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15069382
83* GATA2_21666600_ChIP-Seq_HMVEC_Human1.14955266
84TFEB_21752829_ChIP-Seq_HELA_Human1.14701543
85MYB_26560356_Chip-Seq_TH2_Human1.14215442
86* NCOR1_26117541_ChIP-Seq_K562_Human1.14141490
87KDM2B_26808549_Chip-Seq_K562_Human1.13235131
88* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13169078
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12615581
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12571683
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12239622
92ZNF263_19887448_ChIP-Seq_K562_Human1.12220117
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12194682
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10337638
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.09550277
96PU_27001747_Chip-Seq_BMDM_Mouse1.07500012
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07297310
98MYB_26560356_Chip-Seq_TH1_Human1.06898011
99* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05985125
100* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05985125
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05819579
102* MAF_26560356_Chip-Seq_TH2_Human1.05577232
103TP53_22127205_ChIP-Seq_IMR90_Human1.04514187
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04126644
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03933921
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03132777
107* BCOR_27268052_Chip-Seq_Bcells_Human1.02812766
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01653064
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.00639595
110* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00242504
111GATA1_19941826_ChIP-Seq_K562_Human1.00041826
112* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97166960
113SPI1_20517297_ChIP-Seq_HL60_Human0.96722198
114* ELF1_20517297_ChIP-Seq_JURKAT_Human0.96493070
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96238676
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96105072
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96017503
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95768799
119* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95632791
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95386729
121* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94817442
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.94298479
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93208782
124BCL6_27268052_Chip-Seq_Bcells_Human0.92976895
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92941043
126GATA1_22025678_ChIP-Seq_K562_Human0.92654321
127GATA3_27048872_Chip-Seq_THYMUS_Human0.90911075
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88502116
129* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87761396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.65735712
2MP0003705_abnormal_hypodermis_morpholog3.01737422
3MP0003436_decreased_susceptibility_to2.97400634
4MP0009278_abnormal_bone_marrow2.76626698
5MP0008438_abnormal_cutaneous_collagen2.68504295
6MP0009785_altered_susceptibility_to2.57777277
7MP0004510_myositis2.55108781
8MP0005451_abnormal_body_composition2.33215128
9MP0001835_abnormal_antigen_presentation2.31893363
10MP0003566_abnormal_cell_adhesion2.31350296
11MP0000685_abnormal_immune_system2.30127701
12MP0010352_gastrointestinal_tract_polyps2.23732726
13MP0005076_abnormal_cell_differentiation2.19592911
14MP0009840_abnormal_foam_cell2.13657680
15MP0002419_abnormal_innate_immunity2.08829207
16MP0004947_skin_inflammation2.05006666
17MP0005058_abnormal_lysosome_morphology2.04701594
18MP0005000_abnormal_immune_tolerance2.04493520
19MP0005387_immune_system_phenotype2.01966348
20MP0001790_abnormal_immune_system2.01966348
21MP0006082_CNS_inflammation2.01371619
22MP0005025_abnormal_response_to1.96903584
23MP0003448_altered_tumor_morphology1.93145518
24MP0002148_abnormal_hypersensitivity_rea1.92186668
25MP0001533_abnormal_skeleton_physiology1.82881914
26MP0003724_increased_susceptibility_to1.82268471
27MP0000343_altered_response_to1.79560926
28MP0005023_abnormal_wound_healing1.74376228
29MP0002452_abnormal_antigen_presenting1.73494597
30MP0008004_abnormal_stomach_pH1.70583046
31MP0003300_gastrointestinal_ulcer1.68121753
32MP0001958_emphysema1.67170530
33MP0001545_abnormal_hematopoietic_system1.66702309
34MP0005397_hematopoietic_system_phenotyp1.66702309
35MP0001800_abnormal_humoral_immune1.59118235
36MP0003763_abnormal_thymus_physiology1.58773638
37MP0002405_respiratory_system_inflammati1.57289433
38MP0002723_abnormal_immune_serum1.53828082
39MP0000858_altered_metastatic_potential1.53337314
40MP0006054_spinal_hemorrhage1.43444225
41MP0004858_abnormal_nervous_system1.43152528
42MP0010307_abnormal_tumor_latency1.41526357
43* MP0003091_abnormal_cell_migration1.40580504
44MP0003453_abnormal_keratinocyte_physiol1.37209977
45MP0001819_abnormal_immune_cell1.37175507
46MP0005623_abnormal_meninges_morphology1.34837150
47MP0005275_abnormal_skin_tensile1.34658477
48MP0002420_abnormal_adaptive_immunity1.34010294
49MP0001845_abnormal_inflammatory_respons1.33605018
50MP0003279_aneurysm1.33019261
51MP0009333_abnormal_splenocyte_physiolog1.31147654
52MP0005464_abnormal_platelet_physiology1.30801966
53MP0002138_abnormal_hepatobiliary_system1.29537151
54MP0002139_abnormal_hepatobiliary_system1.28945437
55MP0000604_amyloidosis1.27180506
56MP0008260_abnormal_autophagy1.25954325
57MP0001348_abnormal_lacrimal_gland1.25332314
58MP0003075_altered_response_to1.24456286
59MP0001853_heart_inflammation1.23045151
60MP0005167_abnormal_blood-brain_barrier1.16212458
61MP0008469_abnormal_protein_level1.16161867
62MP0003191_abnormal_cellular_cholesterol1.16012338
63MP0010155_abnormal_intestine_physiology1.15882380
64MP0003828_pulmonary_edema1.15445019
65MP0002254_reproductive_system_inflammat1.15237121
66MP0009764_decreased_sensitivity_to1.13799896
67MP0002998_abnormal_bone_remodeling1.12800632
68MP0000750_abnormal_muscle_regeneration1.08108727
69MP0000733_abnormal_muscle_development1.07842975
70MP0000767_abnormal_smooth_muscle1.06646212
71MP0003172_abnormal_lysosome_physiology1.06544059
72MP0004272_abnormal_basement_membrane1.04097522
73MP0005164_abnormal_response_to1.03205961
74MP0001542_abnormal_bone_strength1.03098226
75MP0003806_abnormal_nucleotide_metabolis1.01995775
76MP0005390_skeleton_phenotype1.01205017
77MP0001873_stomach_inflammation1.00391337
78MP0003690_abnormal_glial_cell0.99037612
79MP0000716_abnormal_immune_system0.97481253
80MP0005410_abnormal_fertilization0.97420487
81MP0002933_joint_inflammation0.97418569
82MP0002398_abnormal_bone_marrow0.96141401
83MP0002877_abnormal_melanocyte_morpholog0.95220241
84MP0003656_abnormal_erythrocyte_physiolo0.94632783
85MP0005671_abnormal_response_to0.93427996
86MP0005257_abnormal_intraocular_pressure0.92367362
87MP0001663_abnormal_digestive_system0.90871197
88MP0000465_gastrointestinal_hemorrhage0.90802377
89MP0004185_abnormal_adipocyte_glucose0.89327275
90MP0002429_abnormal_blood_cell0.87538885
91MP0000249_abnormal_blood_vessel0.87244725
92MP0000689_abnormal_spleen_morphology0.85676374
93MP0004883_abnormal_blood_vessel0.83691139
94MP0009763_increased_sensitivity_to0.83474827
95MP0005166_decreased_susceptibility_to0.80504396
96MP0005165_increased_susceptibility_to0.80201257
97MP0002722_abnormal_immune_system0.79954317
98MP0008874_decreased_physiological_sensi0.79823986
99MP0002006_tumorigenesis0.78594543
100MP0003221_abnormal_cardiomyocyte_apopto0.78196215
101MP0003183_abnormal_peptide_metabolism0.77341904
102MP0001915_intracranial_hemorrhage0.76140463
103MP0005310_abnormal_salivary_gland0.74856222
104MP0002332_abnormal_exercise_endurance0.73957232
105MP0000703_abnormal_thymus_morphology0.73332604
106MP0005083_abnormal_biliary_tract0.72939679
107MP0003329_amyloid_beta_deposits0.72822778
108MP0001243_abnormal_dermal_layer0.71548162
109MP0009765_abnormal_xenobiotic_induced0.71157191
110MP0004808_abnormal_hematopoietic_stem0.69789053
111MP0001849_ear_inflammation0.69453697
112MP0002136_abnormal_kidney_physiology0.69206940
113MP0005666_abnormal_adipose_tissue0.68521075
114MP0000490_abnormal_crypts_of0.65399973
115* MP0005621_abnormal_cell_physiology0.65163958
116MP0003795_abnormal_bone_structure0.64556994
117MP0003045_fibrosis0.64281890
118MP0001851_eye_inflammation0.64193923
119MP0000569_abnormal_digit_pigmentation0.63994249
120MP0003866_abnormal_defecation0.63095746
121MP0000920_abnormal_myelination0.59042594
122MP0005381_digestive/alimentary_phenotyp0.57033642

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.99415302
2Abnormality of glycolipid metabolism (HP:0010969)4.87250450
3Abnormality of liposaccharide metabolism (HP:0010968)4.87250450
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.87250450
5Recurrent abscess formation (HP:0002722)4.77691127
6Recurrent bacterial skin infections (HP:0005406)4.17211907
7Recurrent gram-negative bacterial infections (HP:0005420)4.09488984
8Peritonitis (HP:0002586)3.79834780
9Abnormality of macrophages (HP:0004311)3.77311173
10Premature rupture of membranes (HP:0001788)3.62418492
11Autoimmune thrombocytopenia (HP:0001973)3.43366036
12Abnormality of the nasal mucosa (HP:0000433)3.41398727
13Elevated erythrocyte sedimentation rate (HP:0003565)3.35680339
14Orchitis (HP:0100796)3.29767095
15Protrusio acetabuli (HP:0003179)3.25806445
16Nasal polyposis (HP:0100582)3.25411048
17Keratoconjunctivitis sicca (HP:0001097)3.23139429
18Mediastinal lymphadenopathy (HP:0100721)3.22529604
19Vertebral compression fractures (HP:0002953)3.21994365
20Stomatitis (HP:0010280)3.19849672
21Increased cerebral lipofuscin (HP:0011813)3.12754545
22Tetraparesis (HP:0002273)3.06018875
23Cerebral aneurysm (HP:0004944)3.05812921
24Myositis (HP:0100614)3.05064359
25Increased IgM level (HP:0003496)2.91151071
26Systemic lupus erythematosus (HP:0002725)2.90812951
27Myocardial infarction (HP:0001658)2.89825871
28Keratoconjunctivitis (HP:0001096)2.89622995
29Hematochezia (HP:0002573)2.85467347
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.83369154
31Osteolytic defects of the hand bones (HP:0009699)2.83369154
32Gingivitis (HP:0000230)2.83276907
33Interstitial pulmonary disease (HP:0006530)2.81674110
34Increased IgE level (HP:0003212)2.81651702
35Distal upper limb amyotrophy (HP:0007149)2.77540042
36Upper limb amyotrophy (HP:0009129)2.77540042
37Meningitis (HP:0001287)2.73928639
38Increased connective tissue (HP:0009025)2.72562604
39Hand muscle atrophy (HP:0009130)2.68164013
40Retrobulbar optic neuritis (HP:0100654)2.65203269
41Optic neuritis (HP:0100653)2.65203269
42Gastrointestinal stroma tumor (HP:0100723)2.65132610
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.64233898
44Urticaria (HP:0001025)2.60874518
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59134774
46Abnormality of polysaccharide metabolism (HP:0011012)2.59134774
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59134774
48Nuclear cataract (HP:0100018)2.57527918
49Petechiae (HP:0000967)2.56438234
50Pustule (HP:0200039)2.55527826
51Purpura (HP:0000979)2.53794822
52Neurofibrillary tangles (HP:0002185)2.46396250
53Encephalitis (HP:0002383)2.46273031
54Cellulitis (HP:0100658)2.45284423
55Ulnar bowing (HP:0003031)2.41586707
56Vacuolated lymphocytes (HP:0001922)2.40269694
57Cervical subluxation (HP:0003308)2.40122470
58Polycythemia (HP:0001901)2.39546176
59Gangrene (HP:0100758)2.38309519
60Axonal loss (HP:0003447)2.37974942
61Shallow orbits (HP:0000586)2.36710684
62Difficulty climbing stairs (HP:0003551)2.35336939
63Hypergammaglobulinemia (HP:0010702)2.32403894
64Hemoptysis (HP:0002105)2.30756388
65Recurrent skin infections (HP:0001581)2.29913732
66Chronic obstructive pulmonary disease (HP:0006510)2.28848358
67Obstructive lung disease (HP:0006536)2.28848358
68Recurrent fungal infections (HP:0002841)2.27289905
69Esophageal varix (HP:0002040)2.26544756
70Abnormality of proline metabolism (HP:0010907)2.26033025
71Hydroxyprolinuria (HP:0003080)2.26033025
72Increased serum ferritin (HP:0003281)2.24955636
73Vasculitis (HP:0002633)2.23941304
74T lymphocytopenia (HP:0005403)2.22338663
75Mutism (HP:0002300)2.20172093
76Hepatosplenomegaly (HP:0001433)2.15605929
77Autoimmune hemolytic anemia (HP:0001890)2.13869463
78Thick nail (HP:0001805)2.12590367
79Apathy (HP:0000741)2.12549570
80Metaphyseal cupping (HP:0003021)2.12398615
81Glomerulopathy (HP:0100820)2.10318525
82Episodic fever (HP:0001954)2.07810507
83Loss of speech (HP:0002371)2.07092691
84Cerebral inclusion bodies (HP:0100314)2.06267309
85Anorexia (HP:0002039)2.06194017
86Porencephaly (HP:0002132)2.06107670
87Abnormality of T cell number (HP:0011839)2.05974583
88Arterial thrombosis (HP:0004420)2.04258111
89Progressive neurologic deterioration (HP:0002344)2.04151030
90Dilatation of the ascending aorta (HP:0005111)2.04072866
91Restrictive lung disease (HP:0002091)2.03645639
92Neuronal loss in central nervous system (HP:0002529)2.03620126
93Diminished motivation (HP:0000745)2.03494171
94Colitis (HP:0002583)2.03262374
95Frequent falls (HP:0002359)2.03102938
96Fused cervical vertebrae (HP:0002949)2.03079115
97Prolonged bleeding time (HP:0003010)2.01482120
98Abnormality of the peritoneum (HP:0002585)2.01377215
99Lymphopenia (HP:0001888)2.00285641
100Genu recurvatum (HP:0002816)1.99325930
101Gastrointestinal infarctions (HP:0005244)1.99195641
102Hypertensive crisis (HP:0100735)1.99138192
103Arthralgia (HP:0002829)1.98963710
104Polyneuropathy (HP:0001271)1.98439838
105Epistaxis (HP:0000421)1.97676882
106Spontaneous hematomas (HP:0007420)1.97552239
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.97092228
108Asymmetric septal hypertrophy (HP:0001670)1.96095780
109Increased density of long bones (HP:0006392)1.95990988
110Inflammation of the large intestine (HP:0002037)1.95942511
111Abnormality of the pleura (HP:0002103)1.94473499
112Gastrointestinal inflammation (HP:0004386)1.94220870
113Pulmonary infiltrates (HP:0002113)1.93768707
114Short nail (HP:0001799)1.92541228
115Emphysema (HP:0002097)1.91187848
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.89838008
117Abnormality of the pericardium (HP:0001697)1.89611164
118Parakeratosis (HP:0001036)1.89560835
119Acne (HP:0001061)1.89373856
120Nephritis (HP:0000123)1.86656710
121IgA deficiency (HP:0002720)1.86361749
122Ankle contracture (HP:0006466)1.85429482
123Dysostosis multiplex (HP:0000943)1.85304030
124Joint swelling (HP:0001386)1.85284165
125Hemorrhage of the eye (HP:0011885)1.82631331
126Abnormality of iron homeostasis (HP:0011031)1.82315583
127Achilles tendon contracture (HP:0001771)1.80482476
128Amyloidosis (HP:0011034)1.79313866
129Radial bowing (HP:0002986)1.79071428
130Leukocytosis (HP:0001974)1.78319161
131Muscle fiber splitting (HP:0003555)1.76121960
132Recurrent viral infections (HP:0004429)1.75994703
133Nausea (HP:0002018)1.74179848
134Persistence of primary teeth (HP:0006335)1.71470856
135Reticulocytosis (HP:0001923)1.70653408
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70626230
137Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70623220
138Coxa vara (HP:0002812)1.70534057
139Aortic dissection (HP:0002647)1.70506510
140Aneurysm (HP:0002617)1.69720329
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69035645
142Mucopolysacchariduria (HP:0008155)1.68570673
143Urinary glycosaminoglycan excretion (HP:0003541)1.68570673
144Glomerulonephritis (HP:0000099)1.68178888
145Esophageal neoplasm (HP:0100751)1.68149931
146Neoplasm of head and neck (HP:0012288)1.68149931
147Distal lower limb amyotrophy (HP:0008944)1.66363003
148Disinhibition (HP:0000734)1.65723779
149Periodontitis (HP:0000704)1.64394549
150Abnormality of the Achilles tendon (HP:0005109)1.64294204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.37992925
2TBK13.17218554
3ERN13.00351126
4PRPF4B2.99432800
5MAP3K142.80131651
6BLK2.53802809
7TTN2.51335865
8TESK12.36341716
9EPHB12.14314140
10BMX2.01808278
11MAP3K101.98176853
12GRK71.96325497
13PKN21.92412833
14TYK21.90341350
15IKBKB1.88298110
16IRAK31.86131245
17MAP4K11.84870117
18PIM21.81064536
19RPS6KA41.80307904
20STK101.72294661
21CSK1.69083213
22IKBKE1.68037973
23CDK121.65577537
24RIPK41.61005948
25EPHA21.59754304
26PTK61.58423424
27RIPK11.58409457
28ICK1.51980647
29FGR1.51616746
30CHUK1.45236573
31JAK31.45069470
32LRRK21.34300717
33CDC42BPA1.34281247
34TXK1.32371809
35MAP3K111.27690249
36MAP3K11.23786560
37BMPR21.23625689
38TESK21.20785122
39PAK41.19606787
40NME21.19405237
41SIK31.18408601
42PIM11.15018594
43MAP2K31.14839341
44ZAP701.14649944
45DDR21.13311095
46IRAK41.10842578
47MAP3K31.10371880
48SYK1.08079565
49JAK11.06868127
50IRAK20.98254033
51PTK20.97197791
52ARAF0.96237705
53MST1R0.94702976
54PDGFRA0.92995826
55FGFR40.91402569
56MARK30.91352635
57LYN0.90857102
58KIT0.90506196
59ALK0.88437922
60ABL20.87689157
61MAP3K80.86886953
62HCK0.86445429
63PTK2B0.85988834
64TAOK10.84011392
65MET0.83156691
66SIK20.82899579
67SMG10.81936418
68IRAK10.81918234
69PBK0.81218360
70FES0.80142564
71NEK20.79633167
72EEF2K0.79561377
73DAPK30.75256182
74MTOR0.75034521
75MATK0.73969898
76TNK20.73755577
77STK30.73151044
78PDK40.70456332
79PDK30.70456332
80KDR0.68675937
81PRKG20.67981148
82TGFBR20.66941492
83SIK10.66913009
84DYRK1B0.66744993
85CSF1R0.66277472
86HIPK20.65730444
87MAP3K50.65514592
88STK40.65275431
89JAK20.63717313
90PRKD20.60953507
91MOS0.60367481
92MAPKAPK20.59742632
93CDK40.58056245
94MST40.57640633
95PAK10.57326162
96MARK20.56916695
97CDK60.56554344
98PDK20.53777238
99CLK10.53118334
100PAK20.53006599
101TYRO30.52177501
102PDK10.51311704
103DMPK0.51202930
104MAP3K130.51167377
105LATS20.50457588
106CAMK1D0.49640582
107MAP2K20.49409492
108PDGFRB0.48996586
109RPS6KC10.48907974
110RPS6KL10.48907974
111BTK0.48889393
112TAOK20.48281309
113SCYL20.47299468
114ABL10.47011201
115KSR20.46919340
116EPHB20.46786037
117LCK0.46387193
118RPS6KA10.46386996
119TRPM70.45837812
120MAPK70.45837740
121MAPK40.45413479
122* EGFR0.45389284
123GRK60.43833535
124NEK90.43295647
125GSK3A0.42179816
126PDPK10.41355263
127RPS6KA20.36175421
128BRAF0.35276547
129RPS6KA60.34815628
130FYN0.31599189
131MAP2K60.29253501
132TAOK30.28685329
133DYRK30.28151560
134MAPK110.26918850

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.12535015
2Staphylococcus aureus infection_Homo sapiens_hsa051502.59252856
3Legionellosis_Homo sapiens_hsa051342.59089889
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.30311461
5Malaria_Homo sapiens_hsa051442.27130892
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21252361
7Osteoclast differentiation_Homo sapiens_hsa043802.18242538
8TNF signaling pathway_Homo sapiens_hsa046682.12028791
9Pertussis_Homo sapiens_hsa051332.05325333
10Graft-versus-host disease_Homo sapiens_hsa053322.03892792
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02189658
12Tuberculosis_Homo sapiens_hsa051521.85399720
13Shigellosis_Homo sapiens_hsa051311.83197100
14Toxoplasmosis_Homo sapiens_hsa051451.82651005
15Salmonella infection_Homo sapiens_hsa051321.73477757
16Allograft rejection_Homo sapiens_hsa053301.70480528
17Apoptosis_Homo sapiens_hsa042101.69384800
18Amoebiasis_Homo sapiens_hsa051461.64316502
19Measles_Homo sapiens_hsa051621.62682415
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60249456
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58670231
22Influenza A_Homo sapiens_hsa051641.53606875
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50310216
24Primary immunodeficiency_Homo sapiens_hsa053401.49828462
25B cell receptor signaling pathway_Homo sapiens_hsa046621.49257840
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42348441
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40876925
28Small cell lung cancer_Homo sapiens_hsa052221.40427235
29Viral myocarditis_Homo sapiens_hsa054161.38331450
30Lysosome_Homo sapiens_hsa041421.36839964
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34096319
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29176291
33Phagosome_Homo sapiens_hsa041451.28514561
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.28254249
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.27960983
36Chronic myeloid leukemia_Homo sapiens_hsa052201.25318103
37Herpes simplex infection_Homo sapiens_hsa051681.25251776
38Rheumatoid arthritis_Homo sapiens_hsa053231.25046178
39Asthma_Homo sapiens_hsa053101.23048879
40Antigen processing and presentation_Homo sapiens_hsa046121.22274411
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15831412
42Hematopoietic cell lineage_Homo sapiens_hsa046401.14438267
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.11089132
44Hepatitis B_Homo sapiens_hsa051611.09617681
45Acute myeloid leukemia_Homo sapiens_hsa052211.08414903
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07371866
47African trypanosomiasis_Homo sapiens_hsa051431.04448290
48Proteoglycans in cancer_Homo sapiens_hsa052051.03802615
49Hepatitis C_Homo sapiens_hsa051600.99218578
50Chemokine signaling pathway_Homo sapiens_hsa040620.97782059
51Focal adhesion_Homo sapiens_hsa045100.97096032
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.96316303
53VEGF signaling pathway_Homo sapiens_hsa043700.91003292
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89758413
55Viral carcinogenesis_Homo sapiens_hsa052030.88135480
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87577025
57HIF-1 signaling pathway_Homo sapiens_hsa040660.86927752
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86754218
59Bladder cancer_Homo sapiens_hsa052190.85703418
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.84605839
61Epstein-Barr virus infection_Homo sapiens_hsa051690.82625823
62ECM-receptor interaction_Homo sapiens_hsa045120.82595772
63MicroRNAs in cancer_Homo sapiens_hsa052060.81491144
64Type I diabetes mellitus_Homo sapiens_hsa049400.81003683
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.79104713
66Other glycan degradation_Homo sapiens_hsa005110.78622993
67Pancreatic cancer_Homo sapiens_hsa052120.77678803
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76593448
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75913058
70p53 signaling pathway_Homo sapiens_hsa041150.74808198
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74186945
72Insulin resistance_Homo sapiens_hsa049310.73653546
73Adherens junction_Homo sapiens_hsa045200.73527603
74Prion diseases_Homo sapiens_hsa050200.65999476
75HTLV-I infection_Homo sapiens_hsa051660.64578334
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.63633594
77Notch signaling pathway_Homo sapiens_hsa043300.63004043
78T cell receptor signaling pathway_Homo sapiens_hsa046600.59691637
79Non-small cell lung cancer_Homo sapiens_hsa052230.59005637
80Complement and coagulation cascades_Homo sapiens_hsa046100.58023945
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57745206
82mTOR signaling pathway_Homo sapiens_hsa041500.56967271
83Prolactin signaling pathway_Homo sapiens_hsa049170.54415745
84* Endocytosis_Homo sapiens_hsa041440.53160577
85Mineral absorption_Homo sapiens_hsa049780.51896957
86Renal cell carcinoma_Homo sapiens_hsa052110.50596693
87Pentose phosphate pathway_Homo sapiens_hsa000300.49307567
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48902618
89Platelet activation_Homo sapiens_hsa046110.47298968
90Dorso-ventral axis formation_Homo sapiens_hsa043200.44539310
91Caffeine metabolism_Homo sapiens_hsa002320.44208602
92Autoimmune thyroid disease_Homo sapiens_hsa053200.42262148
93MAPK signaling pathway_Homo sapiens_hsa040100.42118716
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41848079
95PPAR signaling pathway_Homo sapiens_hsa033200.41767767
96Sphingolipid metabolism_Homo sapiens_hsa006000.41713050
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.41592880
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.40360243
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40306207
100FoxO signaling pathway_Homo sapiens_hsa040680.39506773
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36732357
102Type II diabetes mellitus_Homo sapiens_hsa049300.35379286
103Prostate cancer_Homo sapiens_hsa052150.35115568
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34039273
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33626232
106Fructose and mannose metabolism_Homo sapiens_hsa000510.33269565
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32805983
108Galactose metabolism_Homo sapiens_hsa000520.32775414
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32600752
110GnRH signaling pathway_Homo sapiens_hsa049120.32443662
111Endometrial cancer_Homo sapiens_hsa052130.32055825
112Selenocompound metabolism_Homo sapiens_hsa004500.31778606
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31557530
114ErbB signaling pathway_Homo sapiens_hsa040120.31164199
115Fat digestion and absorption_Homo sapiens_hsa049750.30336759
116Vibrio cholerae infection_Homo sapiens_hsa051100.30024953
117Insulin signaling pathway_Homo sapiens_hsa049100.24366603
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23773982

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