EHD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.66113810
2low-density lipoprotein particle clearance (GO:0034383)5.35436240
3retina vasculature morphogenesis in camera-type eye (GO:0061299)4.98342319
4vascular endothelial growth factor signaling pathway (GO:0038084)4.73168205
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.72195728
6type B pancreatic cell proliferation (GO:0044342)4.67538658
7regulation of sequestering of triglyceride (GO:0010889)4.34086819
8basement membrane organization (GO:0071711)4.32902235
9collagen fibril organization (GO:0030199)4.32441615
10kidney mesenchyme development (GO:0072074)4.30759922
11extracellular matrix assembly (GO:0085029)4.30167956
12glomerular filtration (GO:0003094)4.09146785
13renal filtration (GO:0097205)4.08805249
14fibril organization (GO:0097435)3.95684876
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.95206899
16white fat cell differentiation (GO:0050872)3.95113911
17plasma membrane repair (GO:0001778)3.88127495
18metanephric mesenchyme development (GO:0072075)3.83426336
19glomerular basement membrane development (GO:0032836)3.81195225
20barbed-end actin filament capping (GO:0051016)3.76833023
21cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.71545898
22brown fat cell differentiation (GO:0050873)3.67884667
23adhesion of symbiont to host cell (GO:0044650)3.63003740
24virion attachment to host cell (GO:0019062)3.63003740
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.57970501
26axon extension involved in axon guidance (GO:0048846)3.57970501
27lymph vessel development (GO:0001945)3.55433973
28chondrocyte proliferation (GO:0035988)3.54200328
29hemidesmosome assembly (GO:0031581)3.50605310
30endodermal cell differentiation (GO:0035987)3.49539521
31lipid particle organization (GO:0034389)3.49457992
32endothelial cell morphogenesis (GO:0001886)3.48732092
33apoptotic cell clearance (GO:0043277)3.43470008
34ovulation from ovarian follicle (GO:0001542)3.42091676
35substrate-dependent cell migration (GO:0006929)3.41545103
36regulation of tight junction assembly (GO:2000810)3.40201989
37fatty acid transmembrane transport (GO:1902001)3.39881865
38positive regulation of fatty acid oxidation (GO:0046321)3.39641822
39negative regulation of fatty acid transport (GO:2000192)3.38476898
40lymphangiogenesis (GO:0001946)3.36235909
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.36164705
42triglyceride catabolic process (GO:0019433)3.35773801
43positive regulation of endothelial cell apoptotic process (GO:2000353)3.35606750
44protein retention in ER lumen (GO:0006621)3.33516108
45adhesion of symbiont to host (GO:0044406)3.33285618
46blood vessel maturation (GO:0001955)3.31955888
47cell migration involved in sprouting angiogenesis (GO:0002042)3.29310895
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26578506
49cell adhesion mediated by integrin (GO:0033627)3.26230782
50cell-substrate junction assembly (GO:0007044)3.25804875
51collagen metabolic process (GO:0032963)3.24783765
52COPI coating of Golgi vesicle (GO:0048205)3.21157696
53Golgi transport vesicle coating (GO:0048200)3.21157696
54endocardial cushion development (GO:0003197)3.20940346
55multicellular organismal macromolecule metabolic process (GO:0044259)3.20500219
56carnitine shuttle (GO:0006853)3.18801029
57epithelial cell-cell adhesion (GO:0090136)3.16670652
58regulation of cholesterol storage (GO:0010885)3.16590026
59collagen catabolic process (GO:0030574)3.12911203
60skin morphogenesis (GO:0043589)3.12401194
61cell-substrate adherens junction assembly (GO:0007045)3.11900400
62focal adhesion assembly (GO:0048041)3.11900400
63stress fiber assembly (GO:0043149)3.11675115
64negative regulation of nitric-oxide synthase activity (GO:0051001)3.10287422
65multicellular organismal metabolic process (GO:0044236)3.08698526
66muscle cell migration (GO:0014812)3.06447523
67sequestering of extracellular ligand from receptor (GO:0035581)3.05442976
68wound healing, spreading of epidermal cells (GO:0035313)3.01830313
69extracellular matrix organization (GO:0030198)3.01096525
70regulation of fatty acid oxidation (GO:0046320)3.01036284
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00467709
72extracellular structure organization (GO:0043062)2.99934498
73negative regulation of smooth muscle cell migration (GO:0014912)2.99927380
74protein localization to endosome (GO:0036010)2.97184620
75fibroblast migration (GO:0010761)2.96875348
76cardiac myofibril assembly (GO:0055003)2.96870852
77multicellular organismal catabolic process (GO:0044243)2.94089241
78mesenchymal-epithelial cell signaling (GO:0060638)2.92082766
79cellular response to vitamin (GO:0071295)2.91989807
80acylglycerol catabolic process (GO:0046464)2.90222905
81neutral lipid catabolic process (GO:0046461)2.90222905
82surfactant homeostasis (GO:0043129)2.89901235
83growth hormone receptor signaling pathway (GO:0060396)2.89793482
84peptidyl-proline hydroxylation (GO:0019511)2.88727805
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88579591
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.88161267
87smooth muscle tissue development (GO:0048745)2.87554978
88glomerular visceral epithelial cell development (GO:0072015)2.86899649
89extracellular matrix disassembly (GO:0022617)2.86403118
90blood vessel endothelial cell migration (GO:0043534)2.85225982
91vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83624567
92heart trabecula formation (GO:0060347)2.82924716
93hypotonic response (GO:0006971)2.81705802
94sprouting angiogenesis (GO:0002040)2.81691542
95protein hydroxylation (GO:0018126)2.81072408
96positive regulation of osteoblast proliferation (GO:0033690)2.79846435
97regulation of fatty acid beta-oxidation (GO:0031998)2.79379193
98tooth mineralization (GO:0034505)2.78964183
99heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78780718
100valine metabolic process (GO:0006573)2.78423393
101dermatan sulfate metabolic process (GO:0030205)2.78349190
102regulation of extracellular matrix disassembly (GO:0010715)2.78223126
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78004158
104hippo signaling (GO:0035329)2.77738284
105peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77171039
106regulation of p38MAPK cascade (GO:1900744)2.76887225
107dermatan sulfate biosynthetic process (GO:0030208)2.76043376
108positive regulation of receptor recycling (GO:0001921)2.75943487
109wound healing, spreading of cells (GO:0044319)2.74564948
110biotin metabolic process (GO:0006768)2.71708778
111hyaluronan catabolic process (GO:0030214)2.70635481
112regulation of smooth muscle cell migration (GO:0014910)2.70540123
113sarcomere organization (GO:0045214)2.69871694
114positive regulation of glycogen biosynthetic process (GO:0045725)2.69703587
115mesodermal cell differentiation (GO:0048333)2.69577976
116cellular response to vitamin D (GO:0071305)2.69258353
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68540994
118adherens junction assembly (GO:0034333)2.67700183
119venous blood vessel morphogenesis (GO:0048845)2.67520317
120negative regulation of protein autophosphorylation (GO:0031953)2.67211612
121membrane raft organization (GO:0031579)2.67078675
122positive regulation of p38MAPK cascade (GO:1900745)2.66921210
123regulation of plasminogen activation (GO:0010755)2.66419902
124keratan sulfate catabolic process (GO:0042340)2.66276474
125cell migration involved in heart development (GO:0060973)2.65731632
126negative regulation of BMP signaling pathway (GO:0030514)2.64556995
127cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64134204
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64104753
129protein localization to cell surface (GO:0034394)2.64071194
130desmosome organization (GO:0002934)2.63985489
131regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62032333
132substrate adhesion-dependent cell spreading (GO:0034446)2.60602434
133regulation of cartilage development (GO:0061035)2.59567710
134negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.58439882
135negative regulation of cartilage development (GO:0061037)2.57807678
136positive regulation of cellular response to insulin stimulus (GO:1900078)2.57675792
137trabecula formation (GO:0060343)2.56165323
138cardiac muscle cell proliferation (GO:0060038)2.56063468
139cellular response to growth hormone stimulus (GO:0071378)2.55161972
140glomerular epithelial cell development (GO:0072310)2.54512598
141regulation of endothelial cell differentiation (GO:0045601)2.53952330
142atrioventricular valve morphogenesis (GO:0003181)2.52670598
143bone trabecula formation (GO:0060346)2.52574160
144extracellular fibril organization (GO:0043206)2.51486414
145negative regulation of chondrocyte differentiation (GO:0032331)2.51389277
146regulation of integrin-mediated signaling pathway (GO:2001044)2.51173201
147negative regulation of catenin import into nucleus (GO:0035414)2.49341468
148negative regulation of heart growth (GO:0061117)2.47942776
149negative regulation of cardiac muscle tissue growth (GO:0055022)2.47942776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.37221987
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.36029057
3TRIM28_21343339_ChIP-Seq_HEK293_Human5.13563734
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.19179792
5CLOCK_20551151_ChIP-Seq_293T_Human4.13285051
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.59752368
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62473626
8* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.59972066
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.44015573
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42099969
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34751884
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31403238
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.23467723
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.20778801
15CJUN_26792858_Chip-Seq_BT549_Human2.11656770
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06026175
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.03024827
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98541370
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.98295778
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.98295778
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96235707
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95611118
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.91935173
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.88573618
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.87864364
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85713536
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.73475254
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66127715
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62595473
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60773221
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.60068287
32BRD4_25478319_ChIP-Seq_HGPS_Human1.57905590
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.54540618
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53899469
35ZNF263_19887448_ChIP-Seq_K562_Human1.53425604
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52293480
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.50816916
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.50806104
39PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.49287666
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48225210
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48225210
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40603321
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38717124
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.38541608
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36999958
46SA1_22415368_ChIP-Seq_MEFs_Mouse1.35672569
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34582658
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33656692
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33536095
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33536095
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32496030
52PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.31694859
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26443103
54RACK7_27058665_Chip-Seq_MCF-7_Human1.25610998
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25240549
56* SOX2_20726797_ChIP-Seq_SW620_Human1.23945888
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22294415
58SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21691065
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21553639
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20775080
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19880728
62ATF3_27146783_Chip-Seq_COLON_Human1.19695546
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17471772
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16585987
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16404846
66* UBF1/2_26484160_Chip-Seq_HMECs_Human1.16099675
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14461329
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14198976
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13868867
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13724100
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12894236
72* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12488744
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12048802
74* TET1_21490601_ChIP-Seq_MESCs_Mouse1.11158973
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10388389
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07578996
77LXR_22158963_ChIP-Seq_LIVER_Mouse1.07553931
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06890138
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06031624
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05714311
81KDM2B_26808549_Chip-Seq_K562_Human1.03070748
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02883948
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.02015122
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01379891
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99594818
86TCF4_18268006_ChIP-ChIP_LS174T_Human0.98608015
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98564477
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97979272
89KDM2B_26808549_Chip-Seq_DND41_Human0.97015356
90LXR_22292898_ChIP-Seq_THP-1_Human0.96612587
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96164058
92TP53_22127205_ChIP-Seq_IMR90_Human0.95800511
93RUNX1_27514584_Chip-Seq_MCF-7_Human0.95372353
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.95247272
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95154697
96TP53_18474530_ChIP-ChIP_U2OS_Human0.94897135
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94665255
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94665255
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94532885
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94490494
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94283433
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93475281
103* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93237348
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93168446
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92650986
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91767783
107TP53_16413492_ChIP-PET_HCT116_Human0.90750903
108* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89839512
109GATA1_22025678_ChIP-Seq_K562_Human0.88486106
110AHR_22903824_ChIP-Seq_MCF-7_Human0.87575221
111RXR_22108803_ChIP-Seq_LS180_Human0.87366918
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86951352
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85373884
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83805441
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.83233538
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.82940787
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82578750
118SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82525581
119* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82381767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.26414816
2MP0005275_abnormal_skin_tensile4.36813023
3MP0003705_abnormal_hypodermis_morpholog3.62277800
4MP0004272_abnormal_basement_membrane3.60420251
5MP0005670_abnormal_white_adipose3.54265036
6MP0003279_aneurysm2.91044425
7MP0005503_abnormal_tendon_morphology2.85233253
8MP0010368_abnormal_lymphatic_system2.83639128
9MP0005666_abnormal_adipose_tissue2.58774662
10MP0001958_emphysema2.55929161
11MP0002837_dystrophic_cardiac_calcinosis2.51134744
12MP0004130_abnormal_muscle_cell2.47373846
13MP0000013_abnormal_adipose_tissue2.46458064
14MP0001879_abnormal_lymphatic_vessel2.41374791
15MP0004185_abnormal_adipocyte_glucose2.40660312
16MP0003566_abnormal_cell_adhesion2.27653535
17MP0000751_myopathy2.25375290
18MP0004084_abnormal_cardiac_muscle2.23481936
19MP0005375_adipose_tissue_phenotype2.18848899
20MP0005623_abnormal_meninges_morphology2.11328542
21MP0000003_abnormal_adipose_tissue1.94499807
22MP0000750_abnormal_muscle_regeneration1.85815893
23MP0003828_pulmonary_edema1.79033552
24MP0006054_spinal_hemorrhage1.74503541
25MP0006138_congestive_heart_failure1.73320167
26MP0002060_abnormal_skin_morphology1.66557748
27MP0008775_abnormal_heart_ventricle1.57502719
28MP0004087_abnormal_muscle_fiber1.49357010
29MP0005330_cardiomyopathy1.49020466
30MP0003950_abnormal_plasma_membrane1.48414941
31MP0002295_abnormal_pulmonary_circulatio1.47465782
32MP0009384_cardiac_valve_regurgitation1.46511650
33MP0004036_abnormal_muscle_relaxation1.42274606
34MP0003091_abnormal_cell_migration1.42030655
35MP0005385_cardiovascular_system_phenoty1.40347194
36MP0001544_abnormal_cardiovascular_syste1.40347194
37MP0000767_abnormal_smooth_muscle1.40157431
38MP0000749_muscle_degeneration1.36708117
39MP0004215_abnormal_myocardial_fiber1.36354536
40MP0002108_abnormal_muscle_morphology1.35229515
41MP0004858_abnormal_nervous_system1.32489718
42MP0005023_abnormal_wound_healing1.29011605
43MP0005620_abnormal_muscle_contractility1.28889284
44MP0003045_fibrosis1.28877281
45MP0002971_abnormal_brown_adipose1.27751187
46MP0002972_abnormal_cardiac_muscle1.26688382
47MP0000733_abnormal_muscle_development1.25923344
48MP0010630_abnormal_cardiac_muscle1.25390814
49MP0005508_abnormal_skeleton_morphology1.24193950
50MP0009115_abnormal_fat_cell1.23321204
51MP0000343_altered_response_to1.22134184
52MP0000534_abnormal_ureter_morphology1.20985235
53MP0000762_abnormal_tongue_morphology1.20768067
54MP0010352_gastrointestinal_tract_polyps1.19519287
55MP0001849_ear_inflammation1.16067594
56MP0000759_abnormal_skeletal_muscle1.15671115
57MP0003724_increased_susceptibility_to1.07452052
58MP0002128_abnormal_blood_circulation1.02327960
59MP0009053_abnormal_anal_canal1.01463205
60MP0005595_abnormal_vascular_smooth1.00607839
61MP0002896_abnormal_bone_mineralization0.98817385
62MP0005167_abnormal_blood-brain_barrier0.96526586
63MP0009780_abnormal_chondrocyte_physiolo0.96238062
64MP0001348_abnormal_lacrimal_gland0.95255865
65MP0001614_abnormal_blood_vessel0.94947759
66MP0004484_altered_response_of0.94035582
67MP0002877_abnormal_melanocyte_morpholog0.93843433
68MP0002168_other_aberrant_phenotype0.92318613
69MP0001661_extended_life_span0.91632870
70MP0005369_muscle_phenotype0.90664547
71MP0005164_abnormal_response_to0.90095956
72MP0003385_abnormal_body_wall0.89365295
73MP0002106_abnormal_muscle_physiology0.89293688
74MP0003942_abnormal_urinary_system0.88592158
75MP0010030_abnormal_orbit_morphology0.87825302
76MP0005334_abnormal_fat_pad0.86633570
77MP0003191_abnormal_cellular_cholesterol0.86494157
78MP0001243_abnormal_dermal_layer0.85586202
79MP0000467_abnormal_esophagus_morphology0.85565045
80MP0002133_abnormal_respiratory_system0.85542406
81MP0005388_respiratory_system_phenotype0.85542406
82MP0001542_abnormal_bone_strength0.85417024
83MP0002970_abnormal_white_adipose0.85273759
84MP0005409_darkened_coat_color0.84250533
85MP0002925_abnormal_cardiovascular_devel0.84043764
86MP0009250_abnormal_appendicular_skeleto0.82753124
87MP0000249_abnormal_blood_vessel0.81118817
88MP0002796_impaired_skin_barrier0.80428588
89MP0000266_abnormal_heart_morphology0.78049890
90MP0003300_gastrointestinal_ulcer0.78028542
91MP0003646_muscle_fatigue0.77464491
92MP0009840_abnormal_foam_cell0.74950746
93MP0005197_abnormal_uvea_morphology0.74731151
94MP0000163_abnormal_cartilage_morphology0.74633165
95MP0003941_abnormal_skin_development0.74019235
96MP0000858_altered_metastatic_potential0.72809066
97MP0000428_abnormal_craniofacial_morphol0.72583185
98MP0003959_abnormal_lean_body0.71267263
99MP0005076_abnormal_cell_differentiation0.71021329
100MP0005390_skeleton_phenotype0.70998172
101MP0002113_abnormal_skeleton_development0.70523560
102MP0005165_increased_susceptibility_to0.70044644
103MP0001915_intracranial_hemorrhage0.69475929
104MP0004233_abnormal_muscle_weight0.69159195
105MP0003115_abnormal_respiratory_system0.68714974
106MP0005257_abnormal_intraocular_pressure0.68097530
107MP0002269_muscular_atrophy0.67360678
108MP0002998_abnormal_bone_remodeling0.66980438
109MP0003448_altered_tumor_morphology0.66586539
110MP0004134_abnormal_chest_morphology0.66556907
111MP0002933_joint_inflammation0.65857467
112MP0010386_abnormal_urinary_bladder0.65736145
113MP0001175_abnormal_lung_morphology0.65110528
114MP0000462_abnormal_digestive_system0.64602556
115MP0003283_abnormal_digestive_organ0.64578052
116MP0001299_abnormal_eye_distance/0.64569395
117MP0004883_abnormal_blood_vessel0.64268522
118MP0002332_abnormal_exercise_endurance0.63928245
119MP0002115_abnormal_skeleton_extremities0.62339653
120MP0000049_abnormal_middle_ear0.62091537
121MP0002932_abnormal_joint_morphology0.61270934
122MP0010771_integument_phenotype0.60471949
123MP0005058_abnormal_lysosome_morphology0.58824021
124MP0003795_abnormal_bone_structure0.56017396

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.31615157
2Premature rupture of membranes (HP:0001788)6.17234509
3Ankle contracture (HP:0006466)4.88077410
4Increased connective tissue (HP:0009025)4.80206202
5Broad metatarsal (HP:0001783)4.48737620
6Cerebral aneurysm (HP:0004944)4.42987228
7Aortic dissection (HP:0002647)4.37122880
8Type 1 muscle fiber predominance (HP:0003803)4.23440334
9Spinal rigidity (HP:0003306)4.00220096
10Shallow orbits (HP:0000586)3.97383798
11Aortic aneurysm (HP:0004942)3.95391956
12Atrophic scars (HP:0001075)3.86415418
13Muscle fiber splitting (HP:0003555)3.70230666
14Increased variability in muscle fiber diameter (HP:0003557)3.59469886
15Follicular hyperkeratosis (HP:0007502)3.49101574
16Soft skin (HP:0000977)3.32232522
17Acanthosis nigricans (HP:0000956)3.29712090
18Right ventricular cardiomyopathy (HP:0011663)3.28824195
19Fragile skin (HP:0001030)3.27761264
20Abnormality of skeletal muscle fiber size (HP:0012084)3.24574929
21Dilatation of the ascending aorta (HP:0005111)3.14298361
22Hyporeflexia of lower limbs (HP:0002600)3.10944251
23Bladder diverticulum (HP:0000015)3.05807546
24Difficulty running (HP:0009046)3.03721913
25Peritonitis (HP:0002586)2.98151191
26Mildly elevated creatine phosphokinase (HP:0008180)2.97303093
27Mitral valve prolapse (HP:0001634)2.90933071
28Spondylolisthesis (HP:0003302)2.79808670
29Cervical subluxation (HP:0003308)2.79654167
30Aneurysm (HP:0002617)2.78109621
31Lipoatrophy (HP:0100578)2.77581533
32Slender build (HP:0001533)2.68688237
33Aortic regurgitation (HP:0001659)2.68315885
34Ventricular tachycardia (HP:0004756)2.63754512
35Wrist flexion contracture (HP:0001239)2.60509441
36Blue sclerae (HP:0000592)2.54339790
37Sudden death (HP:0001699)2.52148892
38Difficulty climbing stairs (HP:0003551)2.49609847
39Oligomenorrhea (HP:0000876)2.47296789
40Aortic valve stenosis (HP:0001650)2.42224985
41Wormian bones (HP:0002645)2.40699089
42Venous abnormality (HP:0002624)2.38038394
43Joint stiffness (HP:0001387)2.35915099
44Lymphangioma (HP:0100764)2.34001627
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.33910732
46Osteolytic defects of the hand bones (HP:0009699)2.33910732
47Scapular winging (HP:0003691)2.33587898
48Abnormality of dentin (HP:0010299)2.31140178
49Genu recurvatum (HP:0002816)2.29941932
50Neonatal short-limb short stature (HP:0008921)2.28562404
51Vascular tortuosity (HP:0004948)2.26641739
52Natal tooth (HP:0000695)2.25992995
53Hematochezia (HP:0002573)2.22619047
54Hypoventilation (HP:0002791)2.21991808
55Hyperextensible skin (HP:0000974)2.17348688
56Overgrowth (HP:0001548)2.16711266
57Atrial fibrillation (HP:0005110)2.15918379
58Disproportionate tall stature (HP:0001519)2.15100654
59Achilles tendon contracture (HP:0001771)2.14255499
60Round ear (HP:0100830)2.12226370
61Rectal prolapse (HP:0002035)2.11968014
62Vertebral compression fractures (HP:0002953)2.11408703
63Distal upper limb amyotrophy (HP:0007149)2.11238198
64Upper limb amyotrophy (HP:0009129)2.11238198
65Venous insufficiency (HP:0005293)2.10210410
66Elbow flexion contracture (HP:0002987)2.08327301
67Joint laxity (HP:0001388)2.08068911
68Reduced subcutaneous adipose tissue (HP:0003758)2.08014433
69Mesangial abnormality (HP:0001966)2.06997309
70Buphthalmos (HP:0000557)2.06735982
71Hypertriglyceridemia (HP:0002155)2.04154383
72Breech presentation (HP:0001623)2.03225341
73Myoglobinuria (HP:0002913)2.01931442
74Supraventricular arrhythmia (HP:0005115)2.01663993
75Camptodactyly of toe (HP:0001836)2.00758822
76Mitral stenosis (HP:0001718)2.00232920
77Distal lower limb muscle weakness (HP:0009053)1.98339450
78Wide anterior fontanel (HP:0000260)1.98304291
79Primary atrial arrhythmia (HP:0001692)1.98089219
80Myotonia (HP:0002486)1.96930750
81Ectopia lentis (HP:0001083)1.96079149
82Abnormality of the calf musculature (HP:0001430)1.95823511
83Arterial tortuosity (HP:0005116)1.95104578
84Protruding ear (HP:0000411)1.94261202
85Coronal craniosynostosis (HP:0004440)1.94102455
86Polycythemia (HP:0001901)1.93721969
87Bone cyst (HP:0012062)1.88759648
88Generalized amyotrophy (HP:0003700)1.88270640
89Limb-girdle muscle weakness (HP:0003325)1.87436285
90Cardiovascular calcification (HP:0011915)1.86287731
91Bowel diverticulosis (HP:0005222)1.85956095
92Nonimmune hydrops fetalis (HP:0001790)1.85692176
93Supraventricular tachycardia (HP:0004755)1.85330633
94Abnormality of the Achilles tendon (HP:0005109)1.84279984
95Facial diplegia (HP:0001349)1.83090152
96Coxa vara (HP:0002812)1.83050585
97Ulnar bowing (HP:0003031)1.82322682
98Mitral regurgitation (HP:0001653)1.82253274
99Striae distensae (HP:0001065)1.82221550
100Biconcave vertebral bodies (HP:0004586)1.81397789
101Hypoplastic ischia (HP:0003175)1.81072523
102Thin bony cortex (HP:0002753)1.80607969
103Hypoplasia of the iris (HP:0007676)1.79972285
104Hip contracture (HP:0003273)1.79521272
105Pulmonary artery stenosis (HP:0004415)1.79298730
106Abnormality of the 4th metacarpal (HP:0010012)1.78903843
107Inguinal hernia (HP:0000023)1.77750609
108Abnormality of the acetabulum (HP:0003170)1.77310183
109Thin skin (HP:0000963)1.77007058
110Delayed cranial suture closure (HP:0000270)1.76891631
111Long toe (HP:0010511)1.76426522
112EMG: myopathic abnormalities (HP:0003458)1.75770978
113Abnormality of skull ossification (HP:0002703)1.74945021
114Abnormal delivery (HP:0001787)1.74563527
115Joint contractures involving the joints of the feet (HP:0100492)1.73763484
116Flexion contracture of toe (HP:0005830)1.73763484
117Ovoid vertebral bodies (HP:0003300)1.73716669
118Knee flexion contracture (HP:0006380)1.73242142
119Short nail (HP:0001799)1.73194469
120Enlarged penis (HP:0000040)1.73065608
121Insulin-resistant diabetes mellitus (HP:0000831)1.72789706
122Dilated cardiomyopathy (HP:0001644)1.72646108
123Bradycardia (HP:0001662)1.72294329
124Infantile muscular hypotonia (HP:0008947)1.71061815
125Premature skin wrinkling (HP:0100678)1.70593065
126Short hallux (HP:0010109)1.69900359
127Mild short stature (HP:0003502)1.69777525
128Deviation of the hallux (HP:0010051)1.69311845
129Distal lower limb amyotrophy (HP:0008944)1.68859941
130Broad face (HP:0000283)1.67796126
131Mesomelia (HP:0003027)1.67666996
132Hyperacusis (HP:0010780)1.64863035
133Redundant skin (HP:0001582)1.64674872
134Ulnar deviation of the wrist (HP:0003049)1.63738223
135Glucose intolerance (HP:0000833)1.63359504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.90050235
2TTN3.86591301
3TIE13.78928218
4SIK12.68288450
5CAMK1D2.67390589
6RIPK12.65477388
7PDGFRA2.58739710
8ERN12.53652803
9PKN22.46703418
10EPHB22.46284292
11TGFBR22.44324501
12NTRK12.43626012
13MYLK2.37083487
14DDR22.35480230
15LATS12.20095805
16KDR2.08049013
17DMPK2.01830675
18CAMK1G1.87868240
19LMTK21.78358840
20FER1.69972717
21LATS21.69576755
22PDK41.64568864
23PDK31.64568864
24PTK2B1.53600224
25PDK21.49363275
26PAK21.43827751
27STK381.42628613
28PIK3CA1.41465168
29LRRK21.29383942
30ILK1.28947541
31PTK61.24666376
32BCKDK1.23319498
33ARAF1.21805228
34TRPM71.19105826
35MAP3K61.18997587
36EPHB11.13639402
37FGFR21.07037883
38PTK21.05121016
39MET1.04763568
40FGFR31.04146898
41PAK41.03931152
42MAP3K31.03922271
43PDGFRB1.03214625
44NEK91.01811284
45EPHA31.00348060
46PRKD11.00093127
47BMX1.00035743
48ERBB40.98706940
49TGFBR10.98696732
50RPS6KA20.96675759
51PAK30.96658197
52ADRBK10.95442180
53ROCK10.91691424
54GRK50.90736873
55PHKG20.90074031
56PHKG10.90074031
57MAP2K30.87903781
58IRAK30.87643259
59MAP2K10.87575136
60PRPF4B0.86924530
61MST1R0.86821504
62STK30.86519732
63PRKAA20.85991948
64MTOR0.85978104
65AKT30.84457624
66SMG10.84431563
67KIT0.83993725
68FGFR10.83445744
69FGFR40.82981028
70TAOK20.82564103
71FRK0.80683880
72MAPK70.78502719
73MAPKAPK30.78167897
74PRKD30.75934910
75EEF2K0.75768748
76CDK60.75117104
77PRKG20.73896331
78GRK70.69825015
79STK38L0.68561455
80CDK80.65685655
81PRKCH0.65247214
82RET0.63710682
83JAK10.63681224
84RPS6KA40.63645764
85TESK10.62381935
86OBSCN0.60905336
87PRKD20.60635941
88PAK60.59023890
89PAK10.58509710
90PIK3CG0.53544713
91MAP3K100.51268058
92ROCK20.49264414
93CAMK2G0.49151698
94CLK10.48612773
95EPHA20.48612020
96FLT30.48153616
97MAPK120.47996100
98LIMK10.47552227
99CDK90.46552458
100DAPK30.46481421
101INSR0.45798823
102GSK3A0.45399513
103STK100.45017551
104MELK0.44641139
105STK240.44129664
106MOS0.43492742
107CDC42BPA0.42323845
108IGF1R0.40972519
109SRC0.40753824
110INSRR0.40491572
111MAPK40.39694256
112PDPK10.39099917
113RPS6KC10.37734403
114RPS6KL10.37734403
115PRKAA10.37625216
116MAP3K70.36169612
117HIPK20.35756497
118TESK20.34225781
119KSR20.34207448
120ZAP700.34036109
121CSK0.31191758
122NME20.30346648
123MAP3K80.29815980
124CDK120.27812636
125PIM20.25718173
126MAP3K130.25152739
127MARK20.24593737
128WNK10.24548584
129MAPKAPK20.24219072
130JAK30.23992098
131ABL10.23718842
132ABL20.22210771
133ICK0.20044407

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.70786814
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.17110272
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.04539632
4Focal adhesion_Homo sapiens_hsa045102.75478997
5PPAR signaling pathway_Homo sapiens_hsa033202.58177742
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.51608990
7Fatty acid biosynthesis_Homo sapiens_hsa000612.49391094
8Dilated cardiomyopathy_Homo sapiens_hsa054142.40475012
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.36827518
10Propanoate metabolism_Homo sapiens_hsa006402.33355846
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11257078
12Fatty acid metabolism_Homo sapiens_hsa012122.04515862
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99799768
14Protein digestion and absorption_Homo sapiens_hsa049741.94938781
15Adherens junction_Homo sapiens_hsa045201.91354047
16Fatty acid degradation_Homo sapiens_hsa000711.86025999
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82635826
18Proteoglycans in cancer_Homo sapiens_hsa052051.79789241
19Amoebiasis_Homo sapiens_hsa051461.77640296
20Small cell lung cancer_Homo sapiens_hsa052221.70513158
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.68079692
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65939425
23AMPK signaling pathway_Homo sapiens_hsa041521.53319449
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48982537
25Viral myocarditis_Homo sapiens_hsa054161.45373296
26Insulin resistance_Homo sapiens_hsa049311.35309480
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.32369677
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28866040
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26230818
30TGF-beta signaling pathway_Homo sapiens_hsa043501.21453078
31Glycerolipid metabolism_Homo sapiens_hsa005611.21328593
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19749366
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18822552
34Other glycan degradation_Homo sapiens_hsa005111.18495590
35Malaria_Homo sapiens_hsa051441.17447104
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17185622
37Prion diseases_Homo sapiens_hsa050201.16173505
38Bladder cancer_Homo sapiens_hsa052191.12208764
39Tight junction_Homo sapiens_hsa045301.10448769
40Insulin signaling pathway_Homo sapiens_hsa049101.06832748
41Hippo signaling pathway_Homo sapiens_hsa043901.04201449
42Platelet activation_Homo sapiens_hsa046111.04115319
43Carbon metabolism_Homo sapiens_hsa012001.01237469
44Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99728634
45Pyruvate metabolism_Homo sapiens_hsa006200.98226804
46HIF-1 signaling pathway_Homo sapiens_hsa040660.98071562
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97789321
48Caffeine metabolism_Homo sapiens_hsa002320.96750858
49Chronic myeloid leukemia_Homo sapiens_hsa052200.96421644
50MicroRNAs in cancer_Homo sapiens_hsa052060.95168967
51Toxoplasmosis_Homo sapiens_hsa051450.93093651
52Melanoma_Homo sapiens_hsa052180.90424091
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.89111304
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88135458
55Rap1 signaling pathway_Homo sapiens_hsa040150.87181041
56Galactose metabolism_Homo sapiens_hsa000520.85976163
57Pathways in cancer_Homo sapiens_hsa052000.85554102
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.85212924
59Basal cell carcinoma_Homo sapiens_hsa052170.85000892
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84252191
61Pentose phosphate pathway_Homo sapiens_hsa000300.82409561
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82331886
63Complement and coagulation cascades_Homo sapiens_hsa046100.81542100
64Renin secretion_Homo sapiens_hsa049240.78832757
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78552064
66Glucagon signaling pathway_Homo sapiens_hsa049220.78107891
67Vibrio cholerae infection_Homo sapiens_hsa051100.76751047
68Renal cell carcinoma_Homo sapiens_hsa052110.76476560
69N-Glycan biosynthesis_Homo sapiens_hsa005100.73317455
70Pancreatic cancer_Homo sapiens_hsa052120.70918408
71Lysosome_Homo sapiens_hsa041420.69176357
72Fat digestion and absorption_Homo sapiens_hsa049750.68279848
73VEGF signaling pathway_Homo sapiens_hsa043700.66211357
74GnRH signaling pathway_Homo sapiens_hsa049120.64239110
75Pertussis_Homo sapiens_hsa051330.63513670
76Prostate cancer_Homo sapiens_hsa052150.62568477
77Notch signaling pathway_Homo sapiens_hsa043300.62488929
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62027065
79Glioma_Homo sapiens_hsa052140.61686346
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59694943
81Sulfur metabolism_Homo sapiens_hsa009200.58651278
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58502459
83mTOR signaling pathway_Homo sapiens_hsa041500.57860730
84Ovarian steroidogenesis_Homo sapiens_hsa049130.57078268
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56519165
86beta-Alanine metabolism_Homo sapiens_hsa004100.55119767
87Renin-angiotensin system_Homo sapiens_hsa046140.54475141
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53996994
89Acute myeloid leukemia_Homo sapiens_hsa052210.53736862
90Thyroid cancer_Homo sapiens_hsa052160.53453414
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53212959
92Axon guidance_Homo sapiens_hsa043600.52380097
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.52163650
94Lysine degradation_Homo sapiens_hsa003100.52045193
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51089688
96HTLV-I infection_Homo sapiens_hsa051660.48764922
97Estrogen signaling pathway_Homo sapiens_hsa049150.48509458
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47366719
99FoxO signaling pathway_Homo sapiens_hsa040680.44953457
100Cocaine addiction_Homo sapiens_hsa050300.44885918
101Sulfur relay system_Homo sapiens_hsa041220.44694581
102Cardiac muscle contraction_Homo sapiens_hsa042600.44509280
103Endometrial cancer_Homo sapiens_hsa052130.44284727
104Fructose and mannose metabolism_Homo sapiens_hsa000510.43446543
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.43432821
106Gap junction_Homo sapiens_hsa045400.43235827
107Glutathione metabolism_Homo sapiens_hsa004800.42891450
108p53 signaling pathway_Homo sapiens_hsa041150.42758005
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42664962
110TNF signaling pathway_Homo sapiens_hsa046680.42641259
111MAPK signaling pathway_Homo sapiens_hsa040100.41995052
112Melanogenesis_Homo sapiens_hsa049160.41964885
113Hedgehog signaling pathway_Homo sapiens_hsa043400.40896781
114Shigellosis_Homo sapiens_hsa051310.40587774
115Phenylalanine metabolism_Homo sapiens_hsa003600.40472373
116Ras signaling pathway_Homo sapiens_hsa040140.39419468
117cAMP signaling pathway_Homo sapiens_hsa040240.39413962
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37597785
119Dorso-ventral axis formation_Homo sapiens_hsa043200.36170422
120Oxytocin signaling pathway_Homo sapiens_hsa049210.34829871
121* Endocytosis_Homo sapiens_hsa041440.34368676
122Thyroid hormone synthesis_Homo sapiens_hsa049180.33894244
123Salmonella infection_Homo sapiens_hsa051320.33636075
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.31853892
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31303726
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31176977
127Wnt signaling pathway_Homo sapiens_hsa043100.30797263

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