EHD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.25711845
2L-phenylalanine catabolic process (GO:0006559)4.25711845
3cerebellar granule cell differentiation (GO:0021707)4.03434192
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02836149
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98311049
6L-phenylalanine metabolic process (GO:0006558)3.98311049
7positive regulation of fibroblast migration (GO:0010763)3.96396297
8glomerular visceral epithelial cell development (GO:0072015)3.90114878
9glutamate secretion (GO:0014047)3.65227939
10synaptic vesicle maturation (GO:0016188)3.62253976
11aromatic amino acid family catabolic process (GO:0009074)3.56812672
12regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.56168117
13regulation of platelet aggregation (GO:0090330)3.55128751
14L-amino acid import (GO:0043092)3.52557734
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51795558
16platelet aggregation (GO:0070527)3.48232790
17adenosine receptor signaling pathway (GO:0001973)3.45615029
18locomotory exploration behavior (GO:0035641)3.45397297
19synaptic vesicle exocytosis (GO:0016079)3.45098614
20glomerular epithelial cell development (GO:0072310)3.42329673
21negative regulation of homotypic cell-cell adhesion (GO:0034111)3.41704757
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40283298
23positive regulation of neurotransmitter secretion (GO:0001956)3.37688759
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34780688
25alpha-linolenic acid metabolic process (GO:0036109)3.34697166
26bile acid biosynthetic process (GO:0006699)3.33832986
27amino acid import (GO:0043090)3.31317572
28synaptic vesicle endocytosis (GO:0048488)3.27680858
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21001547
30vocalization behavior (GO:0071625)3.18913593
31vesicle docking involved in exocytosis (GO:0006904)3.17404841
32positive regulation of neurotransmitter transport (GO:0051590)3.15451168
33regulation of neurotransmitter secretion (GO:0046928)3.14491532
34negative regulation of heart contraction (GO:0045822)3.14389493
35neurotransmitter-gated ion channel clustering (GO:0072578)3.14369248
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.14156312
37high-density lipoprotein particle remodeling (GO:0034375)3.12658284
38neurotransmitter secretion (GO:0007269)3.11533899
39regulation of voltage-gated calcium channel activity (GO:1901385)3.11227483
40gamma-aminobutyric acid transport (GO:0015812)3.10893336
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10252943
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.09967319
43regulation of synaptic vesicle exocytosis (GO:2000300)3.06747703
44regulation of ARF protein signal transduction (GO:0032012)3.04095249
45glutamate metabolic process (GO:0006536)3.03257807
46kynurenine metabolic process (GO:0070189)3.03184960
47regulation of glutamate receptor signaling pathway (GO:1900449)3.02703138
48regulation of integrin-mediated signaling pathway (GO:2001044)3.01557973
49negative regulation of fibrinolysis (GO:0051918)3.01282091
50neuronal action potential propagation (GO:0019227)3.00589694
51dicarboxylic acid biosynthetic process (GO:0043650)3.00566931
52cellular ketone body metabolic process (GO:0046950)2.97052960
53tryptophan catabolic process (GO:0006569)2.95268550
54indole-containing compound catabolic process (GO:0042436)2.95268550
55indolalkylamine catabolic process (GO:0046218)2.95268550
56relaxation of smooth muscle (GO:0044557)2.94119919
57neuronal ion channel clustering (GO:0045161)2.93724628
58negative regulation of dendrite morphogenesis (GO:0050774)2.89288310
59regulation of fibrinolysis (GO:0051917)2.87369362
60potassium ion homeostasis (GO:0055075)2.87238937
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.86367580
62regulation of early endosome to late endosome transport (GO:2000641)2.85098442
63drug catabolic process (GO:0042737)2.84687109
64vesicle docking (GO:0048278)2.83284063
65regulation of neuronal synaptic plasticity (GO:0048168)2.82733071
66protein localization to synapse (GO:0035418)2.82694950
67positive regulation of receptor recycling (GO:0001921)2.82547323
68coenzyme catabolic process (GO:0009109)2.81683880
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.80533455
70regulation of cAMP-dependent protein kinase activity (GO:2000479)2.79779176
71regulation of neurotransmitter transport (GO:0051588)2.79162096
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78796482
73regulation of protein activation cascade (GO:2000257)2.78612145
74urea metabolic process (GO:0019627)2.77540746
75urea cycle (GO:0000050)2.77540746
76regulation of synaptic vesicle transport (GO:1902803)2.77488969
77glomerular basement membrane development (GO:0032836)2.77169375
78bile acid metabolic process (GO:0008206)2.77020952
79activation of protein kinase A activity (GO:0034199)2.76656699
80exploration behavior (GO:0035640)2.76088568
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.76051992
82regulation of clathrin-mediated endocytosis (GO:2000369)2.75759405
83cellular potassium ion homeostasis (GO:0030007)2.75199983
84exogenous drug catabolic process (GO:0042738)2.74920525
85reverse cholesterol transport (GO:0043691)2.72920049
86response to gravity (GO:0009629)2.71442575
87sodium ion export (GO:0071436)2.70768305
88neuromuscular process controlling balance (GO:0050885)2.70171008
89potassium ion import (GO:0010107)2.69586506
90dicarboxylic acid catabolic process (GO:0043649)2.68744461
91regulation of homotypic cell-cell adhesion (GO:0034110)2.68689491
92peptidyl-glutamic acid carboxylation (GO:0017187)2.68629813
93protein carboxylation (GO:0018214)2.68629813
94glyoxylate metabolic process (GO:0046487)2.67851743
95tryptophan metabolic process (GO:0006568)2.66948463
96thrombin receptor signaling pathway (GO:0070493)2.65376379
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.64990710
98negative regulation of protein activation cascade (GO:2000258)2.63610864
99negative regulation of cholesterol transport (GO:0032375)2.61473206
100negative regulation of sterol transport (GO:0032372)2.61473206
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61361864
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60215780
103neuron cell-cell adhesion (GO:0007158)2.59881721
104positive regulation of synapse maturation (GO:0090129)2.59844170
105regulation of complement activation (GO:0030449)2.58663551
106macromolecular complex remodeling (GO:0034367)2.58077876
107plasma lipoprotein particle remodeling (GO:0034369)2.58077876
108protein-lipid complex remodeling (GO:0034368)2.58077876
109regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57717059
110ketone body metabolic process (GO:1902224)2.57702360
111regulation of sensory perception of pain (GO:0051930)2.57644895
112regulation of sensory perception (GO:0051931)2.57644895
113neuron recognition (GO:0008038)2.56936258
114extracellular fibril organization (GO:0043206)2.54975381
115regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54886157
116proline transport (GO:0015824)2.54280295
117complement activation, alternative pathway (GO:0006957)2.53678207
118tyrosine metabolic process (GO:0006570)2.53068150
119lysine metabolic process (GO:0006553)2.52908868
120lysine catabolic process (GO:0006554)2.52908868
121regulation of cholesterol esterification (GO:0010872)2.52893884
122relaxation of muscle (GO:0090075)2.52716441
123nitrogen cycle metabolic process (GO:0071941)2.52425163
124synaptic transmission, glutamatergic (GO:0035249)2.52383433
125long-chain fatty acid biosynthetic process (GO:0042759)2.52037814
126positive regulation of membrane potential (GO:0045838)2.51867278
127cell communication involved in cardiac conduction (GO:0086065)2.51773937
128negative regulation of blood circulation (GO:1903523)2.51188503
129neuromuscular process controlling posture (GO:0050884)2.50102022
130cysteine metabolic process (GO:0006534)2.49097819
131negative regulation of heart rate (GO:0010459)2.47561636
132regulation of synapse structural plasticity (GO:0051823)2.47459330
133alpha-amino acid catabolic process (GO:1901606)2.46201088
134platelet degranulation (GO:0002576)2.45660278
135aromatic amino acid family metabolic process (GO:0009072)2.45357007
136homotypic cell-cell adhesion (GO:0034109)2.45135906
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44908540
138sulfur amino acid catabolic process (GO:0000098)2.43939026
139beta-amyloid metabolic process (GO:0050435)2.43346199
140neurotransmitter transport (GO:0006836)2.43000783
141regulation of neurotransmitter levels (GO:0001505)2.41712369
142membrane depolarization during action potential (GO:0086010)2.41026044
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.40701937
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39899000
145neuron-neuron synaptic transmission (GO:0007270)2.38987730
146dendritic spine organization (GO:0097061)2.38750572
147cerebellar Purkinje cell differentiation (GO:0021702)2.38730142
148glutamate receptor signaling pathway (GO:0007215)2.37636373
149postsynaptic membrane organization (GO:0001941)2.37446638
150regulation of female receptivity (GO:0045924)2.37238077
151positive regulation of dendritic spine development (GO:0060999)2.37114509
152cholesterol efflux (GO:0033344)2.36170639
153regulation of synaptic transmission (GO:0050804)2.36074504
154positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.35635133
155acidic amino acid transport (GO:0015800)2.34759749
156phospholipid efflux (GO:0033700)2.34500704
157cellular sodium ion homeostasis (GO:0006883)2.34378900
158cellular modified amino acid catabolic process (GO:0042219)2.33514326
159regulation of platelet activation (GO:0010543)2.33228620
160negative regulation of adherens junction organization (GO:1903392)2.32795294
161negative regulation of cell junction assembly (GO:1901889)2.32795294
162regulation of synaptic plasticity (GO:0048167)2.32514225
163short-chain fatty acid metabolic process (GO:0046459)2.32018324
164cell communication by electrical coupling (GO:0010644)2.31426158
165cellular amino acid catabolic process (GO:0009063)2.30536969
166triglyceride homeostasis (GO:0070328)2.29963956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28053484
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90063374
3GBX2_23144817_ChIP-Seq_PC3_Human2.73686125
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.71028019
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63466839
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59161564
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58630195
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32871970
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31322735
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31322735
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28543323
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22648613
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.22547581
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21549165
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19417438
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17280670
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15170414
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14825734
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14590625
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07623404
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.97371718
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93672948
23DROSHA_22980978_ChIP-Seq_HELA_Human1.92258265
24REST_21632747_ChIP-Seq_MESCs_Mouse1.83695066
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80278893
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.77029457
27AR_21572438_ChIP-Seq_LNCaP_Human1.69059873
28TAF15_26573619_Chip-Seq_HEK293_Human1.68909132
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66858513
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.66577415
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.66404673
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60801810
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.59408166
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59251880
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.59063318
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57502239
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.55128812
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.54850717
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46050461
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.45777890
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40739648
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39574363
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38575273
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37704986
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37390676
46SMAD4_21799915_ChIP-Seq_A2780_Human1.34845624
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33479094
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30239733
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.29967660
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29090097
51GATA1_19941826_ChIP-Seq_K562_Human1.27040388
52TET1_21490601_ChIP-Seq_MESCs_Mouse1.26612337
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26085423
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23107440
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22424932
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21934339
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21556683
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.20543322
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20209150
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19036501
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18780050
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17868528
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16837352
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16282420
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.15196735
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.14851981
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14069848
68P300_19829295_ChIP-Seq_ESCs_Human1.13468847
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12577511
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12511241
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.12365145
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12235132
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11783074
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.10961576
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09265543
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.07001245
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06592176
78LXR_22292898_ChIP-Seq_THP-1_Human1.06205252
79* AR_25329375_ChIP-Seq_VCAP_Human1.05663682
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04359161
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03507811
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02867262
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02697993
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00844265
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00120538
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99896523
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99769674
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99652482
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99115966
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99057990
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.98990337
92AHR_22903824_ChIP-Seq_MCF-7_Human0.98907726
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.98208335
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98083574
95RING1B_27294783_Chip-Seq_ESCs_Mouse0.97346991
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96954042
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96507268
98RXR_22108803_ChIP-Seq_LS180_Human0.95668300
99AR_19668381_ChIP-Seq_PC3_Human0.95471241
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95373263
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95185581
102STAT3_23295773_ChIP-Seq_U87_Human0.95067219
103SMAD3_21741376_ChIP-Seq_EPCs_Human0.94540457
104BCAT_22108803_ChIP-Seq_LS180_Human0.93747568
105SCL_19346495_ChIP-Seq_HPC-7_Human0.93693117
106ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93656531
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93255310
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92933753
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92194940
110SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91174576
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90947883
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90669066
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89462466
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89132734
115KDM2B_26808549_Chip-Seq_K562_Human0.88786734
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88526871
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87103679
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.86574720
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.86500349
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86269279
121GATA2_19941826_ChIP-Seq_K562_Human0.84907580
122KDM2B_26808549_Chip-Seq_DND41_Human0.84613353
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.84060477
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.83676709
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83637050
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83444215
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83340311
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.82591191
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82286917
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82279610
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81885181
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.81526959
133CTCF_27219007_Chip-Seq_Bcells_Human0.80632956
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79881427
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79630577
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79630577
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78768343
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78473702
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.76869425
140HTT_18923047_ChIP-ChIP_STHdh_Human0.76643992
141TCF4_23295773_ChIP-Seq_U87_Human0.75620065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.97775969
2MP0002139_abnormal_hepatobiliary_system4.08714030
3MP0005360_urolithiasis3.99416531
4MP0008438_abnormal_cutaneous_collagen3.89400306
5MP0005085_abnormal_gallbladder_physiolo3.40979882
6MP0003880_abnormal_central_pattern3.31895403
7MP0005464_abnormal_platelet_physiology3.23002099
8MP0005365_abnormal_bile_salt3.05415681
9MP0003635_abnormal_synaptic_transmissio3.03683686
10MP0008875_abnormal_xenobiotic_pharmacok2.77917973
11MP0003705_abnormal_hypodermis_morpholog2.65532102
12MP0004270_analgesia2.62665696
13MP0002822_catalepsy2.52070081
14MP0009745_abnormal_behavioral_response2.49885201
15MP0004510_myositis2.45403807
16MP0003279_aneurysm2.44956451
17MP0001958_emphysema2.43044940
18MP0001968_abnormal_touch/_nociception2.42278045
19MP0002735_abnormal_chemical_nociception2.38573675
20MP0002064_seizures2.37738364
21MP0002063_abnormal_learning/memory/cond2.37201000
22MP0010368_abnormal_lymphatic_system2.36144982
23MP0003329_amyloid_beta_deposits2.35434489
24MP0005503_abnormal_tendon_morphology2.28016108
25MP0008004_abnormal_stomach_pH2.23299005
26MP0003566_abnormal_cell_adhesion2.14872973
27MP0005275_abnormal_skin_tensile2.11321110
28MP0010329_abnormal_lipoprotein_level2.07151911
29MP0002736_abnormal_nociception_after2.04692455
30MP0002572_abnormal_emotion/affect_behav1.99358726
31MP0009046_muscle_twitch1.99333305
32MP0004272_abnormal_basement_membrane1.98024424
33MP0003252_abnormal_bile_duct1.96762699
34MP0002272_abnormal_nervous_system1.91614672
35MP0005332_abnormal_amino_acid1.85751897
36MP0001486_abnormal_startle_reflex1.79976560
37MP0002734_abnormal_mechanical_nocicepti1.76656031
38MP0004858_abnormal_nervous_system1.73839591
39MP0001501_abnormal_sleep_pattern1.71907862
40MP0010386_abnormal_urinary_bladder1.65060124
41MP0004084_abnormal_cardiac_muscle1.64209495
42MP0000604_amyloidosis1.60611428
43MP0001440_abnormal_grooming_behavior1.60070290
44MP0002733_abnormal_thermal_nociception1.57085791
45MP0006054_spinal_hemorrhage1.53292229
46MP0006276_abnormal_autonomic_nervous1.48442248
47MP0005423_abnormal_somatic_nervous1.48415153
48MP0005083_abnormal_biliary_tract1.43250572
49MP0002067_abnormal_sensory_capabilities1.40596415
50MP0003091_abnormal_cell_migration1.37851427
51MP0001970_abnormal_pain_threshold1.37409395
52MP0009780_abnormal_chondrocyte_physiolo1.36225611
53MP0003633_abnormal_nervous_system1.33958636
54MP0003195_calcinosis1.33955117
55MP0002909_abnormal_adrenal_gland1.33437193
56MP0002295_abnormal_pulmonary_circulatio1.30657680
57MP0008872_abnormal_physiological_respon1.28960685
58MP0002118_abnormal_lipid_homeostasis1.28608304
59MP0008874_decreased_physiological_sensi1.28502505
60MP0008569_lethality_at_weaning1.27233662
61MP0000751_myopathy1.23276201
62MP0004811_abnormal_neuron_physiology1.20461023
63MP0000465_gastrointestinal_hemorrhage1.19459486
64MP0004885_abnormal_endolymph1.18398304
65MP0003690_abnormal_glial_cell1.16368989
66MP0002184_abnormal_innervation1.16195619
67MP0001542_abnormal_bone_strength1.13961413
68MP0005535_abnormal_body_temperature1.13856450
69MP0005584_abnormal_enzyme/coenzyme_acti1.13566520
70MP0000230_abnormal_systemic_arterial1.13276289
71MP0003868_abnormal_feces_composition1.12755712
72MP0005167_abnormal_blood-brain_barrier1.12633919
73MP0000013_abnormal_adipose_tissue1.11474397
74MP0003806_abnormal_nucleotide_metabolis1.09547665
75MP0005409_darkened_coat_color1.08754825
76MP0001905_abnormal_dopamine_level1.07913405
77MP0003631_nervous_system_phenotype1.07911645
78MP0008961_abnormal_basal_metabolism1.07714734
79MP0004924_abnormal_behavior1.07490505
80MP0005386_behavior/neurological_phenoty1.07490505
81MP0001348_abnormal_lacrimal_gland1.06303809
82MP0005023_abnormal_wound_healing1.04300281
83MP0000955_abnormal_spinal_cord1.03983564
84MP0002066_abnormal_motor_capabilities/c1.02467537
85MP0003879_abnormal_hair_cell1.01418067
86MP0009840_abnormal_foam_cell0.99324362
87MP0000920_abnormal_myelination0.98403964
88MP0000778_abnormal_nervous_system0.97557103
89MP0001879_abnormal_lymphatic_vessel0.97529027
90MP0004130_abnormal_muscle_cell0.97270468
91MP0003075_altered_response_to0.96158505
92MP0002557_abnormal_social/conspecific_i0.96081490
93MP0009384_cardiac_valve_regurgitation0.95419874
94MP0005646_abnormal_pituitary_gland0.94940383
95MP0001765_abnormal_ion_homeostasis0.94052705
96MP0001666_abnormal_nutrient_absorption0.93055011
97MP0004142_abnormal_muscle_tone0.93053060
98MP0003191_abnormal_cellular_cholesterol0.92305982
99MP0003172_abnormal_lysosome_physiology0.91792636
100MP0001299_abnormal_eye_distance/0.88791078
101MP0004043_abnormal_pH_regulation0.88370624
102MP0005623_abnormal_meninges_morphology0.87881314
103MP0001984_abnormal_olfaction0.87513234
104MP0000609_abnormal_liver_physiology0.86813878
105MP0009643_abnormal_urine_homeostasis0.86802283
106MP0002882_abnormal_neuron_morphology0.86224378
107MP0000767_abnormal_smooth_muscle0.85550701
108MP0004019_abnormal_vitamin_homeostasis0.85131033
109MP0001177_atelectasis0.85040488
110MP0005165_increased_susceptibility_to0.84297608
111MP0001502_abnormal_circadian_rhythm0.83826237
112MP0002229_neurodegeneration0.83782730
113MP0005508_abnormal_skeleton_morphology0.83681310
114MP0002069_abnormal_eating/drinking_beha0.83548511
115MP0003656_abnormal_erythrocyte_physiolo0.82563996
116MP0001849_ear_inflammation0.80082658
117MP0002138_abnormal_hepatobiliary_system0.79494152
118MP0000534_abnormal_ureter_morphology0.79116772
119MP0000639_abnormal_adrenal_gland0.78959944
120MP0002090_abnormal_vision0.78450148
121MP0005319_abnormal_enzyme/_coenzyme0.77892445
122MP0003634_abnormal_glial_cell0.77636315
123MP0002876_abnormal_thyroid_physiology0.76763162
124MP0001661_extended_life_span0.75830736
125MP0005257_abnormal_intraocular_pressure0.74167478
126MP0005620_abnormal_muscle_contractility0.73778109
127MP0005388_respiratory_system_phenotype0.73503510
128MP0002133_abnormal_respiratory_system0.73503510
129MP0002837_dystrophic_cardiac_calcinosis0.72373488
130MP0004134_abnormal_chest_morphology0.70786585
131MP0004215_abnormal_myocardial_fiber0.70234693
132MP0004085_abnormal_heartbeat0.69966158
133MP0002972_abnormal_cardiac_muscle0.69747503
134MP0004484_altered_response_of0.69337011
135MP0009697_abnormal_copulation0.68772988
136MP0003632_abnormal_nervous_system0.68572138
137MP0002128_abnormal_blood_circulation0.68479957
138MP0004036_abnormal_muscle_relaxation0.68452870
139MP0003303_peritoneal_inflammation0.68374784
140MP0000579_abnormal_nail_morphology0.68287155
141MP0001756_abnormal_urination0.67628904
142MP0005595_abnormal_vascular_smooth0.66758063
143MP0005636_abnormal_mineral_homeostasis0.66541326
144MP0008775_abnormal_heart_ventricle0.65733642
145MP0000343_altered_response_to0.64218396
146MP0001986_abnormal_taste_sensitivity0.62932547
147MP0005171_absent_coat_pigmentation0.62447215
148MP0001851_eye_inflammation0.62210662

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.59528547
2Increased mean platelet volume (HP:0011877)5.31662517
3Myokymia (HP:0002411)4.98843730
4Abnormal platelet volume (HP:0011876)4.95097958
5Focal motor seizures (HP:0011153)4.90851340
6Menorrhagia (HP:0000132)4.88561435
7Prolonged bleeding time (HP:0003010)4.71211951
8Premature rupture of membranes (HP:0001788)4.56186373
9Protrusio acetabuli (HP:0003179)4.30637775
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26659612
11Petechiae (HP:0000967)4.25337655
12Increased circulating renin level (HP:0000848)4.10572655
13Purpura (HP:0000979)4.04417633
14Intrahepatic cholestasis (HP:0001406)3.71432510
15Xanthomatosis (HP:0000991)3.63813598
16Focal seizures (HP:0007359)3.59804746
17Prolonged partial thromboplastin time (HP:0003645)3.59224870
18Abnormality of binocular vision (HP:0011514)3.55492689
19Diplopia (HP:0000651)3.55492689
20Aortic aneurysm (HP:0004942)3.54099033
21Hyperlipoproteinemia (HP:0010980)3.50393207
22Atonic seizures (HP:0010819)3.37022691
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33388980
24Obstructive sleep apnea (HP:0002870)3.21677798
25Focal segmental glomerulosclerosis (HP:0000097)3.15514880
26Epistaxis (HP:0000421)3.14274249
27Hypobetalipoproteinemia (HP:0003563)3.12643038
28Vascular tortuosity (HP:0004948)3.10020500
29Gingival bleeding (HP:0000225)3.09606459
30Aortic dissection (HP:0002647)3.05118499
31Visual hallucinations (HP:0002367)3.02519838
32Action tremor (HP:0002345)3.02300219
33Hyperventilation (HP:0002883)2.97905297
34Follicular hyperkeratosis (HP:0007502)2.90896120
35Absence seizures (HP:0002121)2.85992576
36Glomerulosclerosis (HP:0000096)2.77896827
37Epileptic encephalopathy (HP:0200134)2.76341054
38Abnormality of the lower motor neuron (HP:0002366)2.75813630
39Increased variability in muscle fiber diameter (HP:0003557)2.75399774
40Abnormality of dentin (HP:0010299)2.74378461
41Complement deficiency (HP:0004431)2.71178407
42Slender build (HP:0001533)2.70530711
43Hypokalemic alkalosis (HP:0001949)2.69581502
44Ankle contracture (HP:0006466)2.68306911
45Lower limb amyotrophy (HP:0007210)2.68130302
46Arterial tortuosity (HP:0005116)2.66831512
47Febrile seizures (HP:0002373)2.66350686
48Type 1 muscle fiber predominance (HP:0003803)2.65962309
49Supranuclear gaze palsy (HP:0000605)2.65948647
50Cerebral hemorrhage (HP:0001342)2.65930518
51Joint hemorrhage (HP:0005261)2.60826453
52Progressive cerebellar ataxia (HP:0002073)2.59358046
53Ketosis (HP:0001946)2.58792587
54Status epilepticus (HP:0002133)2.56396829
55Alkalosis (HP:0001948)2.56281062
56Spinal rigidity (HP:0003306)2.55324902
57Generalized tonic-clonic seizures (HP:0002069)2.55176025
58Abnormality of the common coagulation pathway (HP:0010990)2.51081058
59Dialeptic seizures (HP:0011146)2.50091238
60Hypoventilation (HP:0002791)2.49620561
61Bladder diverticulum (HP:0000015)2.47346672
62Distal upper limb amyotrophy (HP:0007149)2.43882450
63Upper limb amyotrophy (HP:0009129)2.43882450
64Mild short stature (HP:0003502)2.42638182
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42326921
66Abnormality of skeletal muscle fiber size (HP:0012084)2.41384653
67Hyperammonemia (HP:0001987)2.40833623
68Abnormal platelet function (HP:0011869)2.39580527
69Impaired platelet aggregation (HP:0003540)2.39580527
70Neurofibrillary tangles (HP:0002185)2.39241915
71Torticollis (HP:0000473)2.39054176
72Atrophic scars (HP:0001075)2.38064302
73Gout (HP:0001997)2.36997459
74Neonatal onset (HP:0003623)2.35934242
75Bowel diverticulosis (HP:0005222)2.34670713
76Broad metatarsal (HP:0001783)2.33894521
77Scanning speech (HP:0002168)2.33450143
78Cerebral inclusion bodies (HP:0100314)2.31893387
79Epidermoid cyst (HP:0200040)2.31803131
80Impaired vibration sensation in the lower limbs (HP:0002166)2.31448529
81Papilledema (HP:0001085)2.31402649
82Annular pancreas (HP:0001734)2.30303344
83Potter facies (HP:0002009)2.30292211
84Facial shape deformation (HP:0011334)2.30292211
85Wormian bones (HP:0002645)2.29568844
86Focal dystonia (HP:0004373)2.28646696
87Hemiplegia (HP:0002301)2.28428107
88Hyperglycinemia (HP:0002154)2.28125433
89Soft skin (HP:0000977)2.25536173
90Hypomagnesemia (HP:0002917)2.23332930
91Tetraplegia (HP:0002445)2.22760596
92Impaired social interactions (HP:0000735)2.22645290
93Abnormal social behavior (HP:0012433)2.22645290
94Termporal pattern (HP:0011008)2.21492872
95Insidious onset (HP:0003587)2.21492872
96Dilatation of the ascending aorta (HP:0005111)2.20909402
97Glomerulonephritis (HP:0000099)2.20162264
98Cholecystitis (HP:0001082)2.20031365
99Abnormal gallbladder physiology (HP:0012438)2.20031365
100Fragile skin (HP:0001030)2.19961830
101Craniofacial dystonia (HP:0012179)2.19680386
102Dysmetria (HP:0001310)2.18912007
103Genu recurvatum (HP:0002816)2.18716117
104Spontaneous hematomas (HP:0007420)2.18481285
105Hypolipoproteinemia (HP:0010981)2.17522317
106Neonatal short-limb short stature (HP:0008921)2.15886492
107Spontaneous abortion (HP:0005268)2.15668741
108Pheochromocytoma (HP:0002666)2.15294507
109Anxiety (HP:0000739)2.14655135
110Distal lower limb amyotrophy (HP:0008944)2.14052598
111Lower limb muscle weakness (HP:0007340)2.14041258
112Abnormal eating behavior (HP:0100738)2.13004210
113Delayed CNS myelination (HP:0002188)2.12801785
114Nephritis (HP:0000123)2.10574428
115Ankle clonus (HP:0011448)2.09453655
116Shallow orbits (HP:0000586)2.07959153
117Vascular calcification (HP:0004934)2.06569824
118Bruising susceptibility (HP:0000978)2.06236426
119Depression (HP:0000716)2.05531732
120Sensorimotor neuropathy (HP:0007141)2.04201289
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03946319
122Overgrowth (HP:0001548)2.02616423
123Fat malabsorption (HP:0002630)2.01858868
124Hand muscle atrophy (HP:0009130)2.00843715
125Spastic gait (HP:0002064)2.00743689
126Poor eye contact (HP:0000817)2.00347049
127Urinary urgency (HP:0000012)1.98843084
128Mesangial abnormality (HP:0001966)1.98133529
129Ketoacidosis (HP:0001993)1.97304609
130Hypoplasia of the iris (HP:0007676)1.96858693
131Mitral stenosis (HP:0001718)1.96525374
132Postural instability (HP:0002172)1.94726276
133Abnormality of the intrinsic pathway (HP:0010989)1.94264998
134Rapidly progressive (HP:0003678)1.93991623
135Urinary bladder sphincter dysfunction (HP:0002839)1.93580828
136Conjugated hyperbilirubinemia (HP:0002908)1.93520504
137Intention tremor (HP:0002080)1.92584850
138Clonus (HP:0002169)1.92192929
139Truncal ataxia (HP:0002078)1.92136370
140Abnormality of renin-angiotensin system (HP:0000847)1.91498830
141Bundle branch block (HP:0011710)1.91250646
142Hypoalphalipoproteinemia (HP:0003233)1.91132436
143Abnormality of magnesium homeostasis (HP:0004921)1.90644173
144Abnormality of serine family amino acid metabolism (HP:0010894)1.90435062
145Abnormality of glycine metabolism (HP:0010895)1.90435062
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89544794
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.88861362
148Dysdiadochokinesis (HP:0002075)1.87966602
149Polycythemia (HP:0001901)1.86876682
150Neuroendocrine neoplasm (HP:0100634)1.86421779
151Hammertoe (HP:0001765)1.86309429
152Abnormality of methionine metabolism (HP:0010901)1.85925202
153Blue irides (HP:0000635)1.85702007
154Peritonitis (HP:0002586)1.85307200
155Mildly elevated creatine phosphokinase (HP:0008180)1.84375703
156Blue sclerae (HP:0000592)1.84315084
157Abnormality of the corticospinal tract (HP:0002492)1.83808750
158Insomnia (HP:0100785)1.80676193
159Hyperextensible skin (HP:0000974)1.80194392
160Conjunctival telangiectasia (HP:0000524)1.79565169
161Amyloidosis (HP:0011034)1.79557170
162Delusions (HP:0000746)1.79324043
163Cardiovascular calcification (HP:0011915)1.78821531
164Mitral regurgitation (HP:0001653)1.76394705
165Abnormal atrioventricular conduction (HP:0005150)1.74509958
166Neuronal loss in central nervous system (HP:0002529)1.71908645
167Spinal canal stenosis (HP:0003416)1.70014175
168Mitral valve prolapse (HP:0001634)1.69713400
169Abnormality of the Achilles tendon (HP:0005109)1.69678421
170Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67063841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.14662780
2NTRK33.72470556
3STK393.36592249
4OXSR13.07899894
5EPHA42.64557204
6MAP3K92.54371918
7TIE12.53511924
8MAP3K42.35432967
9MINK12.30198326
10KSR22.17978548
11MAP2K42.14024230
12DAPK21.91974741
13MAP3K121.83673939
14NTRK11.79418769
15KDR1.78038591
16PAK61.67885387
17MAP3K131.60579565
18MAP2K71.58131110
19BMX1.54024034
20FGFR41.46650829
21DDR21.42919237
22MARK11.41508146
23PRKCH1.32740385
24NTRK21.32263806
25FES1.31592958
26KSR11.28648229
27ARAF1.27256002
28CASK1.23928278
29DAPK31.21975621
30PAK21.17927878
31SGK4941.15375178
32SGK2231.15375178
33GRK51.14847684
34PRKD31.13136742
35CDK51.10409922
36CAMKK11.09906157
37STK381.09061763
38RET1.05770054
39PTK2B1.05713590
40TESK11.04703696
41MAP3K21.03915297
42LMTK21.03019795
43MAP3K70.98823673
44PTK20.98673418
45PIK3CG0.98614271
46LIMK10.96770854
47PRKCG0.95974998
48SGK30.95603782
49SGK20.95018552
50CAMK2B0.94812767
51TYRO30.94216066
52SIK20.94210365
53PAK30.94181876
54TGFBR20.93550265
55LATS20.89731269
56NEK90.89214982
57PRKD20.88606957
58ROCK20.88112449
59SIK30.88068670
60BMPR20.87785767
61FER0.87570891
62SIK10.87096747
63DAPK10.86482747
64PDPK10.83434075
65ROCK10.81398687
66PNCK0.79945461
67PDK10.79283627
68PRPF4B0.78978056
69PHKG10.77005099
70PHKG20.77005099
71WNK10.75986045
72MAPK120.75812032
73PRKD10.74215549
74PDGFRB0.74079606
75CAMK2A0.74074035
76MAP3K10.72805217
77PLK20.71323004
78TTN0.70816805
79TEC0.70605703
80PRKG20.69571829
81DYRK1A0.69390135
82ADRBK10.68079623
83SYK0.67399609
84CDK11A0.66846182
85PAK10.66774594
86FGFR20.66645306
87MAP2K10.66620154
88GRK60.65727564
89BRAF0.65692489
90CSNK1G20.64811542
91MYLK0.64749378
92JAK10.64159005
93MAP3K110.63795263
94CAMK10.63611071
95TAOK20.63102041
96MAPK130.62727881
97CDK190.61715165
98CAMK2G0.60420332
99PINK10.59574732
100STK110.58833271
101MARK20.58517370
102BCKDK0.56727641
103PDGFRA0.56622324
104BLK0.56617570
105RAF10.54861730
106DMPK0.53330767
107ZAP700.52673211
108PRKCQ0.52459862
109JAK30.51867152
110PRKCZ0.51852275
111UHMK10.49928483
112RIPK40.48957325
113RPS6KA20.47891003
114CDK140.47349096
115CDC42BPA0.46577076
116MOS0.45848852
117JAK20.45140821
118CDK180.45055970
119PKN10.44713834
120EPHB20.44163505
121MAPK100.44110826
122FYN0.44006201
123CAMK40.43903720
124PRKCE0.43639637
125SGK10.43181818
126CAMKK20.42571194
127CDK150.42557291
128TAOK10.42013300
129CAMK1G0.41928925
130TNK20.40070530
131MAPK70.39887436
132FGFR30.37287163
133TNIK0.36571657
134RIPK10.36250539
135AKT30.35152237
136RPS6KA30.34025916

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.61983933
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.98669784
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83493240
4Arginine biosynthesis_Homo sapiens_hsa002202.44564808
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26312659
6Platelet activation_Homo sapiens_hsa046112.03186631
7Synaptic vesicle cycle_Homo sapiens_hsa047211.96720836
8ECM-receptor interaction_Homo sapiens_hsa045121.96472062
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91923256
10Nicotine addiction_Homo sapiens_hsa050331.85632409
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75386310
12Butanoate metabolism_Homo sapiens_hsa006501.75061827
13Bile secretion_Homo sapiens_hsa049761.71781230
14Complement and coagulation cascades_Homo sapiens_hsa046101.68691037
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67395817
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65287852
17GABAergic synapse_Homo sapiens_hsa047271.61592574
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58284801
19Olfactory transduction_Homo sapiens_hsa047401.55589985
20Circadian entrainment_Homo sapiens_hsa047131.49089222
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47834833
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44690486
23Focal adhesion_Homo sapiens_hsa045101.44600820
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43676495
25Tryptophan metabolism_Homo sapiens_hsa003801.38114762
26Dilated cardiomyopathy_Homo sapiens_hsa054141.37809443
27Long-term potentiation_Homo sapiens_hsa047201.37767897
28Glutamatergic synapse_Homo sapiens_hsa047241.33695848
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33467529
30Salivary secretion_Homo sapiens_hsa049701.30578957
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29875798
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29751421
33Fatty acid degradation_Homo sapiens_hsa000711.27912673
34Morphine addiction_Homo sapiens_hsa050321.27719254
35Amphetamine addiction_Homo sapiens_hsa050311.20589600
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17797299
37Insulin secretion_Homo sapiens_hsa049111.14945797
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14375310
39Propanoate metabolism_Homo sapiens_hsa006401.14138319
40Fatty acid metabolism_Homo sapiens_hsa012121.14009868
41PPAR signaling pathway_Homo sapiens_hsa033201.13802990
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13802069
43Gastric acid secretion_Homo sapiens_hsa049711.13272456
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09018324
45Pancreatic secretion_Homo sapiens_hsa049721.07661342
46Dopaminergic synapse_Homo sapiens_hsa047281.07546985
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06270972
48Pyruvate metabolism_Homo sapiens_hsa006200.98796587
49Renin secretion_Homo sapiens_hsa049240.98415708
50* Endocytosis_Homo sapiens_hsa041440.98323076
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.98263218
52Cholinergic synapse_Homo sapiens_hsa047250.97871022
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97732740
54Amoebiasis_Homo sapiens_hsa051460.95551565
55Taste transduction_Homo sapiens_hsa047420.95322610
56Peroxisome_Homo sapiens_hsa041460.94783927
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92771476
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.92723831
59Ras signaling pathway_Homo sapiens_hsa040140.92512087
60Collecting duct acid secretion_Homo sapiens_hsa049660.91775250
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88358137
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87885630
63Fatty acid elongation_Homo sapiens_hsa000620.86348295
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84571359
65VEGF signaling pathway_Homo sapiens_hsa043700.83979806
66Chemical carcinogenesis_Homo sapiens_hsa052040.82872175
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82355688
68Histidine metabolism_Homo sapiens_hsa003400.82316517
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80264888
70Vibrio cholerae infection_Homo sapiens_hsa051100.79998175
71Proteoglycans in cancer_Homo sapiens_hsa052050.79800686
72Long-term depression_Homo sapiens_hsa047300.79298340
73ABC transporters_Homo sapiens_hsa020100.79053651
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79018393
75Inositol phosphate metabolism_Homo sapiens_hsa005620.78841448
76Oxytocin signaling pathway_Homo sapiens_hsa049210.78806885
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78175875
78Phenylalanine metabolism_Homo sapiens_hsa003600.76302484
79Calcium signaling pathway_Homo sapiens_hsa040200.75992827
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74185245
81beta-Alanine metabolism_Homo sapiens_hsa004100.73423838
82MAPK signaling pathway_Homo sapiens_hsa040100.72671534
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72273124
84Gap junction_Homo sapiens_hsa045400.69928694
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69638671
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.69627786
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69502632
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.68414737
89Endometrial cancer_Homo sapiens_hsa052130.68279036
90cAMP signaling pathway_Homo sapiens_hsa040240.68068274
91Cocaine addiction_Homo sapiens_hsa050300.67204072
92Serotonergic synapse_Homo sapiens_hsa047260.67087887
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.66897794
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66781281
95Axon guidance_Homo sapiens_hsa043600.66702044
96Tyrosine metabolism_Homo sapiens_hsa003500.66303448
97GnRH signaling pathway_Homo sapiens_hsa049120.65321100
98Dorso-ventral axis formation_Homo sapiens_hsa043200.62100515
99Chemokine signaling pathway_Homo sapiens_hsa040620.61776636
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61412560
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60572846
102B cell receptor signaling pathway_Homo sapiens_hsa046620.59807824
103Caffeine metabolism_Homo sapiens_hsa002320.58923979
104Protein digestion and absorption_Homo sapiens_hsa049740.58505942
105Non-small cell lung cancer_Homo sapiens_hsa052230.58365479
106Glycerolipid metabolism_Homo sapiens_hsa005610.58333931
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.57495768
108Prion diseases_Homo sapiens_hsa050200.57093530
109Thyroid hormone synthesis_Homo sapiens_hsa049180.56596361
110Staphylococcus aureus infection_Homo sapiens_hsa051500.55901676
111Melanoma_Homo sapiens_hsa052180.55519060
112Renal cell carcinoma_Homo sapiens_hsa052110.54887975
113Adherens junction_Homo sapiens_hsa045200.54561347
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54290198
115Glucagon signaling pathway_Homo sapiens_hsa049220.53644437
116Glioma_Homo sapiens_hsa052140.52767865
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52649964
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51970551
119Wnt signaling pathway_Homo sapiens_hsa043100.50840679
120Alcoholism_Homo sapiens_hsa050340.50467953
121Estrogen signaling pathway_Homo sapiens_hsa049150.50393633
122Retinol metabolism_Homo sapiens_hsa008300.50174445
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48990259
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47879438
125Shigellosis_Homo sapiens_hsa051310.47582021
126Type II diabetes mellitus_Homo sapiens_hsa049300.47549814
127Chronic myeloid leukemia_Homo sapiens_hsa052200.46640691
128Sulfur metabolism_Homo sapiens_hsa009200.46052404
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46011839
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44524255
131Insulin signaling pathway_Homo sapiens_hsa049100.44267724
132Vitamin B6 metabolism_Homo sapiens_hsa007500.43916276
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.43367585
134Starch and sucrose metabolism_Homo sapiens_hsa005000.43264236
135Hippo signaling pathway_Homo sapiens_hsa043900.42991057
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42568951
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.41371099
138Carbon metabolism_Homo sapiens_hsa012000.40446698
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39924848
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39267549
141Biosynthesis of amino acids_Homo sapiens_hsa012300.39088453
142Melanogenesis_Homo sapiens_hsa049160.38478104
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.36750777
144ErbB signaling pathway_Homo sapiens_hsa040120.36565701
145Steroid biosynthesis_Homo sapiens_hsa001000.35769106
146Rap1 signaling pathway_Homo sapiens_hsa040150.34905411
147Choline metabolism in cancer_Homo sapiens_hsa052310.34778754

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