EHF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.52710119
2branching involved in prostate gland morphogenesis (GO:0060442)7.96073729
3intestinal epithelial cell development (GO:0060576)6.68377446
4UDP-N-acetylglucosamine metabolic process (GO:0006047)6.47916135
5keratinocyte proliferation (GO:0043616)6.01826011
6prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.79237624
7L-fucose catabolic process (GO:0042355)5.61518401
8fucose catabolic process (GO:0019317)5.61518401
9L-fucose metabolic process (GO:0042354)5.61518401
10water homeostasis (GO:0030104)5.60234314
11COPI coating of Golgi vesicle (GO:0048205)5.43109575
12Golgi transport vesicle coating (GO:0048200)5.43109575
13iron ion import (GO:0097286)5.40432652
14artery development (GO:0060840)5.39201283
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.35133699
16keratinocyte differentiation (GO:0030216)5.33934270
17prostate gland epithelium morphogenesis (GO:0060740)5.24380905
18regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.23634076
19hemidesmosome assembly (GO:0031581)5.20980825
20epithelial cell differentiation involved in prostate gland development (GO:0060742)5.09912376
21interferon-gamma secretion (GO:0072643)5.02663983
22desmosome organization (GO:0002934)4.80741187
23N-glycan processing (GO:0006491)4.67840110
24epidermal cell differentiation (GO:0009913)4.57650226
25calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.54720355
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.52340577
27epithelial cell maturation (GO:0002070)4.48720749
28fucose metabolic process (GO:0006004)4.47507959
29lung secretory cell differentiation (GO:0061140)4.44461467
30mannose metabolic process (GO:0006013)4.40520718
31hepatocyte apoptotic process (GO:0097284)4.40466734
32diterpenoid biosynthetic process (GO:0016102)4.34464418
33surfactant homeostasis (GO:0043129)4.32640521
34positive regulation of steroid hormone secretion (GO:2000833)4.10343821
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.02091998
36chemical homeostasis within a tissue (GO:0048875)3.92412215
37epidermis development (GO:0008544)3.91516606
38mitotic cell cycle arrest (GO:0071850)3.87275216
39regulation of water loss via skin (GO:0033561)3.81309028
40axonemal dynein complex assembly (GO:0070286)3.80425329
41skin morphogenesis (GO:0043589)3.77946993
42peptide cross-linking (GO:0018149)3.77056321
43galactose catabolic process (GO:0019388)3.74889791
44regulation of transforming growth factor beta1 production (GO:0032908)3.73042413
45positive regulation of epidermal cell differentiation (GO:0045606)3.70056309
46pyrimidine-containing compound transmembrane transport (GO:0072531)3.69835234
47hypotonic response (GO:0006971)3.68262427
48regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.64952017
49transcytosis (GO:0045056)3.64601867
50activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.63887324
51protein retention in ER lumen (GO:0006621)3.63241425
52negative regulation of keratinocyte proliferation (GO:0010839)3.61553579
53response to testosterone (GO:0033574)3.58461937
54tight junction assembly (GO:0070830)3.58229390
55regulation of receptor binding (GO:1900120)3.57906038
56valine metabolic process (GO:0006573)3.57638726
57glandular epithelial cell differentiation (GO:0002067)3.55619585
58regulation of keratinocyte differentiation (GO:0045616)3.53759251
59keratinocyte development (GO:0003334)3.45359040
60positive regulation of nuclease activity (GO:0032075)3.43934287
61diol metabolic process (GO:0034311)3.41686603
62positive regulation of natural killer cell differentiation (GO:0032825)3.39426922
63gap junction assembly (GO:0016264)3.39242916
64nucleotide-sugar biosynthetic process (GO:0009226)3.39147954
65ventricular cardiac muscle cell action potential (GO:0086005)3.39007901
66nucleotide-sugar metabolic process (GO:0009225)3.38557226
67activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.37691808
68hormone catabolic process (GO:0042447)3.36282393
69regulation of keratinocyte proliferation (GO:0010837)3.33896198
70positive regulation of keratinocyte differentiation (GO:0045618)3.30421854
71vitamin transmembrane transport (GO:0035461)3.27027205
72columnar/cuboidal epithelial cell development (GO:0002066)3.25061679
73endoplasmic reticulum unfolded protein response (GO:0030968)3.20052941
74establishment of skin barrier (GO:0061436)3.19698213
75branching involved in mammary gland duct morphogenesis (GO:0060444)3.19040217
76positive regulation of glycoprotein biosynthetic process (GO:0010560)3.18239218
77regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.17516912
78positive regulation of p38MAPK cascade (GO:1900745)3.17480497
79angiotensin maturation (GO:0002003)3.17390633
80lipoxygenase pathway (GO:0019372)3.15628871
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.14430184
82positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.13892019
83primary alcohol catabolic process (GO:0034310)3.13434675
84positive regulation of glycoprotein metabolic process (GO:1903020)3.13170051
85cilium or flagellum-dependent cell motility (GO:0001539)3.12788943
86biotin metabolic process (GO:0006768)3.11967375
87sphingoid metabolic process (GO:0046519)3.11334733
88regulation of nuclease activity (GO:0032069)3.10723781
89cytoskeletal anchoring at plasma membrane (GO:0007016)3.10398649
90sphingomyelin metabolic process (GO:0006684)3.10391861
91establishment of planar polarity (GO:0001736)3.09550307
92establishment of tissue polarity (GO:0007164)3.09550307
93cellular response to unfolded protein (GO:0034620)3.09185768
94peptide catabolic process (GO:0043171)3.08708231
95auditory receptor cell differentiation (GO:0042491)3.07731066
96positive regulation of growth hormone secretion (GO:0060124)3.07476539
97protein targeting to Golgi (GO:0000042)3.07150954
98positive regulation of epidermis development (GO:0045684)3.04909342
99O-glycan processing (GO:0016266)3.04125617
100sulfur amino acid catabolic process (GO:0000098)3.03964041
101COPII vesicle coating (GO:0048208)3.03248239
102apical protein localization (GO:0045176)3.01695544
103epithelial cell-cell adhesion (GO:0090136)3.01025368
104lung cell differentiation (GO:0060479)2.98944238
105response to endoplasmic reticulum stress (GO:0034976)2.98878591
106ER-nucleus signaling pathway (GO:0006984)2.97793151
107retinol metabolic process (GO:0042572)2.96326455
108pharyngeal system development (GO:0060037)2.95621037
109positive regulation of protein localization to plasma membrane (GO:1903078)2.95325532
110multicellular organismal water homeostasis (GO:0050891)2.95223691
111intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.94686169
112positive regulation of actin filament depolymerization (GO:0030836)2.93395038
113hexose catabolic process (GO:0019320)2.91971148
114ectoderm development (GO:0007398)2.91467010
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.91432818
116sexual reproduction (GO:0019953)2.90324092
117regulation of natural killer cell differentiation (GO:0032823)2.90258707
118terpenoid biosynthetic process (GO:0016114)2.88086435
119cell-cell junction assembly (GO:0007043)2.87983946
120sphingosine metabolic process (GO:0006670)2.86872286
121regulation of cholesterol homeostasis (GO:2000188)2.86419922
122apoptotic cell clearance (GO:0043277)2.84853330
123growth hormone receptor signaling pathway (GO:0060396)2.84448730
124protein N-linked glycosylation via asparagine (GO:0018279)2.84126276
125retinal metabolic process (GO:0042574)2.83824475
126lung lobe morphogenesis (GO:0060463)2.82804327
127import into cell (GO:0098657)2.82753125
128hair cycle (GO:0042633)2.82682788
129molting cycle (GO:0042303)2.82682788
130oligosaccharide biosynthetic process (GO:0009312)2.82516491
131peptidyl-asparagine modification (GO:0018196)2.82508339
132transepithelial transport (GO:0070633)2.82362227
133cellular response to topologically incorrect protein (GO:0035967)2.82227101
134detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.81293066
135asymmetric protein localization (GO:0008105)2.79965935
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79398690
137regulation of protein glycosylation (GO:0060049)2.77681092
138lung epithelial cell differentiation (GO:0060487)2.77316689
139protein localization to endosome (GO:0036010)2.76738611
140antibacterial humoral response (GO:0019731)2.76296092
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.75069699
142GDP-mannose metabolic process (GO:0019673)2.74656306
143establishment of protein localization to Golgi (GO:0072600)2.74332733
144positive regulation of catenin import into nucleus (GO:0035413)2.74180778
145positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.73452523
146ethanol metabolic process (GO:0006067)2.73020462
147L-serine transport (GO:0015825)2.72913486
148negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.72780738
149linoleic acid metabolic process (GO:0043651)2.71972528
150protein autoprocessing (GO:0016540)2.70034462
151mammary gland epithelial cell differentiation (GO:0060644)2.67802193
152positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67500464
153polarized epithelial cell differentiation (GO:0030859)2.66007756
154intermediate filament organization (GO:0045109)2.65659125
155copper ion transport (GO:0006825)2.65042924
156macroautophagy (GO:0016236)2.62814452
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62591339
158regulation of p38MAPK cascade (GO:1900744)2.62236576
159endothelial cell chemotaxis (GO:0035767)2.61122550
160regulation of transforming growth factor beta production (GO:0071634)2.56786135
161regulation of protein localization to cell surface (GO:2000008)2.55709477
162primary alcohol metabolic process (GO:0034308)2.55026463
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.54831785
164antimicrobial humoral response (GO:0019730)2.53749562
165early endosome to late endosome transport (GO:0045022)2.50584773
166regulation of viral release from host cell (GO:1902186)2.49969223
167cilium movement (GO:0003341)2.49579543
168regulation of epidermal cell differentiation (GO:0045604)2.48659857
169receptor catabolic process (GO:0032801)2.48194640
170regulation of heart rate by cardiac conduction (GO:0086091)2.47121368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.12987814
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.67467609
3STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.36519118
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.28188575
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.24779373
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.23883188
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.04877126
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.94076167
9* SOX2_20726797_ChIP-Seq_SW620_Human2.89277894
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.85595966
11* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84286219
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77518327
13GATA4_25053715_ChIP-Seq_YYC3_Human2.77094093
14ZNF263_19887448_ChIP-Seq_K562_Human2.73187067
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59606694
16* GATA6_25053715_ChIP-Seq_YYC3_Human2.46846585
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.40718919
18* FOXO3_23340844_ChIP-Seq_DLD1_Human2.40294225
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31307535
20FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.22922360
21AHR_22903824_ChIP-Seq_MCF-7_Human2.22412252
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.20875934
23* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.20875934
24* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.06802876
25* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04291562
26* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.01898950
27* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.00896546
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.95539214
29* RUNX1_27514584_Chip-Seq_MCF-7_Human1.95093340
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.90531380
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.87749048
32* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87128640
33* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.82869738
34* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.78124754
35CLOCK_20551151_ChIP-Seq_293T_Human1.77977557
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.77955660
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69991585
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69561225
39* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.64806749
40GATA1_22025678_ChIP-Seq_K562_Human1.64698923
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62627515
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59151330
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52046438
44* CJUN_26792858_Chip-Seq_BT549_Human1.50117587
45* KLF5_25053715_ChIP-Seq_YYC3_Human1.49800482
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.45913883
47* FOXA1_25552417_ChIP-Seq_VCAP_Human1.45572869
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.37812476
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35674893
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.34997532
51RACK7_27058665_Chip-Seq_MCF-7_Human1.32474241
52CHD1_26751641_Chip-Seq_LNCaP_Human1.30319989
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29484434
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29206443
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28691676
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.26592621
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26118812
58ATF3_27146783_Chip-Seq_COLON_Human1.24854952
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24746802
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24416291
61* TP63_23658742_ChIP-Seq_EP156T_Human1.23093748
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22222053
63* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22205273
64* AR_21909140_ChIP-Seq_LNCAP_Human1.21733286
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20964920
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19357153
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15415069
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.13840692
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13714995
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.12891362
71* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12814842
72* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12814842
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12085059
74* CDX2_22108803_ChIP-Seq_LS180_Human1.11595393
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10641673
76* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10106380
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07137885
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06614465
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05346903
80* ELF5_23300383_ChIP-Seq_T47D_Human1.03001226
81TP63_22573176_ChIP-Seq_HFKS_Human1.00816627
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00645377
83RXR_22108803_ChIP-Seq_LS180_Human1.00537390
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99982246
85ISL1_27105846_Chip-Seq_CPCs_Mouse0.99551465
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99444686
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99157833
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96823489
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95858660
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95284720
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95007603
92* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94196104
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.92096973
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91458077
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89714019
96* TBX20_22080862_ChIP-Seq_HEART_Mouse0.89704323
97* TBX20_22328084_ChIP-Seq_HEART_Mouse0.89704323
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.88232888
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.87074992
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86741338
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84708753
102CREB1_26743006_Chip-Seq_LNCaP_Human0.83014324
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82569237
104HNF4A_19822575_ChIP-Seq_HepG2_Human0.80893975
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80888456
106ERG_20517297_ChIP-Seq_VCAP_Human0.80425668
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78709478
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78434461
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78434461
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78434461
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77437225
112* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73845058
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73026324
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72031446
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68803017
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67435985
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65777058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.17189348
2MP0003300_gastrointestinal_ulcer4.33647804
3MP0004264_abnormal_extraembryonic_tissu3.85117549
4MP0005310_abnormal_salivary_gland3.82732126
5MP0000537_abnormal_urethra_morphology3.37653198
6MP0002166_altered_tumor_susceptibility3.37020391
7MP0001873_stomach_inflammation2.86480324
8MP0002006_tumorigenesis2.72615956
9MP0010386_abnormal_urinary_bladder2.65313453
10MP0002009_preneoplasia2.59572331
11MP0000613_abnormal_salivary_gland2.47166613
12MP0010678_abnormal_skin_adnexa2.45312124
13MP0002254_reproductive_system_inflammat2.27129605
14MP0000566_synostosis2.24226407
15MP0004043_abnormal_pH_regulation2.16819696
16MP0005647_abnormal_sex_gland2.13787813
17MP0010352_gastrointestinal_tract_polyps2.12842448
18MP0002796_impaired_skin_barrier2.12515262
19MP0000462_abnormal_digestive_system2.07609274
20MP0001765_abnormal_ion_homeostasis2.05150497
21MP0003191_abnormal_cellular_cholesterol2.00008860
22MP0000538_abnormal_urinary_bladder1.96081465
23MP0001346_abnormal_lacrimal_gland1.89776314
24MP0001881_abnormal_mammary_gland1.84517605
25MP0010155_abnormal_intestine_physiology1.83972216
26MP0003866_abnormal_defecation1.83259146
27MP0001666_abnormal_nutrient_absorption1.82816267
28MP0002098_abnormal_vibrissa_morphology1.80110530
29MP0006054_spinal_hemorrhage1.76287793
30MP0008004_abnormal_stomach_pH1.71499737
31MP0000678_abnormal_parathyroid_gland1.67198838
32MP0003453_abnormal_keratinocyte_physiol1.59641666
33MP0001756_abnormal_urination1.58134328
34MP0005220_abnormal_exocrine_pancreas1.56365091
35MP0002138_abnormal_hepatobiliary_system1.51908446
36MP0000490_abnormal_crypts_of1.49017276
37MP0000627_abnormal_mammary_gland1.42780193
38MP0005381_digestive/alimentary_phenotyp1.40407927
39MP0001663_abnormal_digestive_system1.38599899
40MP0005636_abnormal_mineral_homeostasis1.37718828
41MP0002060_abnormal_skin_morphology1.37299859
42MP0004858_abnormal_nervous_system1.35331479
43MP0005409_darkened_coat_color1.34240259
44MP0001664_abnormal_digestion1.33614146
45MP0003566_abnormal_cell_adhesion1.32947599
46MP0002132_abnormal_respiratory_system1.31629364
47MP0009643_abnormal_urine_homeostasis1.30687974
48MP0001216_abnormal_epidermal_layer1.30453640
49MP0000579_abnormal_nail_morphology1.30239606
50MP0009764_decreased_sensitivity_to1.26438606
51MP0003183_abnormal_peptide_metabolism1.24859739
52MP0000383_abnormal_hair_follicle1.24083194
53MP0005275_abnormal_skin_tensile1.23063077
54MP0003045_fibrosis1.23046824
55MP0003705_abnormal_hypodermis_morpholog1.22403956
56MP0004782_abnormal_surfactant_physiolog1.22206439
57MP0000477_abnormal_intestine_morphology1.22022415
58MP0009384_cardiac_valve_regurgitation1.21270886
59MP0002277_abnormal_respiratory_mucosa1.21245821
60MP0003315_abnormal_perineum_morphology1.17422112
61MP0005501_abnormal_skin_physiology1.16776762
62MP0005083_abnormal_biliary_tract1.16437886
63MP0000377_abnormal_hair_follicle1.14634330
64MP0002136_abnormal_kidney_physiology1.11841774
65MP0002295_abnormal_pulmonary_circulatio1.10486618
66MP0000762_abnormal_tongue_morphology1.10406715
67MP0008875_abnormal_xenobiotic_pharmacok1.10252978
68MP0000470_abnormal_stomach_morphology1.09402527
69MP0003941_abnormal_skin_development1.08933123
70MP0009931_abnormal_skin_appearance1.07516558
71MP0005367_renal/urinary_system_phenotyp1.02994322
72MP0000516_abnormal_urinary_system1.02994322
73MP0005408_hypopigmentation1.02817368
74MP0001849_ear_inflammation1.01865799
75MP0005666_abnormal_adipose_tissue0.98013097
76MP0002877_abnormal_melanocyte_morpholog0.95575965
77MP0009780_abnormal_chondrocyte_physiolo0.94602979
78MP0004947_skin_inflammation0.90876631
79MP0005076_abnormal_cell_differentiation0.89912050
80MP0000467_abnormal_esophagus_morphology0.89324627
81MP0003252_abnormal_bile_duct0.89212954
82MP0003950_abnormal_plasma_membrane0.88761799
83MP0000367_abnormal_coat/_hair0.87329160
84MP0000427_abnormal_hair_cycle0.85527583
85MP0005166_decreased_susceptibility_to0.84071130
86MP0002896_abnormal_bone_mineralization0.83629173
87MP0005248_abnormal_Harderian_gland0.82798249
88MP0010771_integument_phenotype0.82753851
89MP0002139_abnormal_hepatobiliary_system0.81796081
90MP0005023_abnormal_wound_healing0.80907802
91MP0001191_abnormal_skin_condition0.77189378
92MP0002168_other_aberrant_phenotype0.76677528
93MP0003936_abnormal_reproductive_system0.76290582
94MP0005085_abnormal_gallbladder_physiolo0.76280415
95MP0004381_abnormal_hair_follicle0.74502886
96MP0005451_abnormal_body_composition0.73174428
97MP0005187_abnormal_penis_morphology0.73002412
98MP0000647_abnormal_sebaceous_gland0.72567893
99MP0005670_abnormal_white_adipose0.71907766
100MP0000465_gastrointestinal_hemorrhage0.71404550
101MP0009765_abnormal_xenobiotic_induced0.70251039
102MP0002876_abnormal_thyroid_physiology0.69882998
103MP0002909_abnormal_adrenal_gland0.67791329
104MP0002163_abnormal_gland_morphology0.67571387
105MP0000534_abnormal_ureter_morphology0.67443505
106MP0005375_adipose_tissue_phenotype0.67381495
107MP0001851_eye_inflammation0.67079647
108MP0003718_maternal_effect0.66098835
109MP0003868_abnormal_feces_composition0.65734415
110MP0004272_abnormal_basement_membrane0.65515296
111MP0005058_abnormal_lysosome_morphology0.63887578
112MP0005164_abnormal_response_to0.63777079
113MP0004185_abnormal_adipocyte_glucose0.63259451
114MP0001944_abnormal_pancreas_morphology0.61545379
115MP0004019_abnormal_vitamin_homeostasis0.60771740
116MP0002282_abnormal_trachea_morphology0.60058050
117MP0003656_abnormal_erythrocyte_physiolo0.58473886
118MP0009379_abnormal_foot_pigmentation0.58128020
119MP0003091_abnormal_cell_migration0.57978335
120MP0002135_abnormal_kidney_morphology0.57229635
121MP0001727_abnormal_embryo_implantation0.56904191
122MP0005165_increased_susceptibility_to0.55017912
123MP0003937_abnormal_limbs/digits/tail_de0.54833067
124MP0000858_altered_metastatic_potential0.53783591
125MP0001845_abnormal_inflammatory_respons0.50176869
126MP0005365_abnormal_bile_salt0.49516285
127MP0001919_abnormal_reproductive_system0.46817473

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.07243071
2Right ventricular cardiomyopathy (HP:0011663)6.36008437
3Abnormality of cochlea (HP:0000375)5.61674193
4Onycholysis (HP:0001806)4.71633289
5Pili torti (HP:0003777)4.36638934
6Chronic bronchitis (HP:0004469)4.20164987
7Milia (HP:0001056)4.14092927
8Rectal prolapse (HP:0002035)4.08676101
9Congenital ichthyosiform erythroderma (HP:0007431)4.05884052
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.91370875
11Morphological abnormality of the inner ear (HP:0011390)3.84219348
12Aortic aneurysm (HP:0004942)3.71947286
13Thick nail (HP:0001805)3.60642667
14Micronodular cirrhosis (HP:0001413)3.58890716
15Hypoplasia of the uterus (HP:0000013)3.39854834
16Atrophic scars (HP:0001075)3.37924721
17Potter facies (HP:0002009)3.36569932
18Facial shape deformation (HP:0011334)3.36569932
19Oral leukoplakia (HP:0002745)3.35642412
20Plantar hyperkeratosis (HP:0007556)3.26908444
21Abnormality of chloride homeostasis (HP:0011422)3.26046987
22Flat acetabular roof (HP:0003180)3.22320490
23Curly hair (HP:0002212)3.22279245
24Woolly hair (HP:0002224)3.20415330
25Rhinitis (HP:0012384)3.17090470
26Biliary tract neoplasm (HP:0100574)3.14786311
27Hyperactive renin-angiotensin system (HP:0000841)3.13189295
28Erythema (HP:0010783)3.08899860
29Lip pit (HP:0100267)3.08860165
30Abnormal respiratory motile cilium physiology (HP:0012261)3.02643206
31Vacuolated lymphocytes (HP:0001922)2.98362096
32Increased IgE level (HP:0003212)2.92531600
33Hypotrichosis (HP:0001006)2.91806024
34Corneal erosion (HP:0200020)2.91190539
35Fragile nails (HP:0001808)2.89015648
36Male infertility (HP:0003251)2.83896795
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81919773
38Subacute progressive viral hepatitis (HP:0006572)2.81665783
39Abnormal hair laboratory examination (HP:0003328)2.81214822
40Sparse eyelashes (HP:0000653)2.80639078
41Decreased circulating renin level (HP:0003351)2.79925617
42Hyperkalemia (HP:0002153)2.79680886
43Subcapsular cataract (HP:0000523)2.79208698
44Advanced eruption of teeth (HP:0006288)2.78980441
45Abdominal distention (HP:0003270)2.77271567
46Abnormal ciliary motility (HP:0012262)2.75701212
47Vascular calcification (HP:0004934)2.73319992
48Abnormality of renin-angiotensin system (HP:0000847)2.71751035
49Abnormality of the 2nd finger (HP:0004100)2.71203458
50Abnormal respiratory motile cilium morphology (HP:0005938)2.66183505
51Abnormal respiratory epithelium morphology (HP:0012253)2.66183505
52Bronchiectasis (HP:0002110)2.66027254
53Villous atrophy (HP:0011473)2.65392395
54Abnormality of small intestinal villus morphology (HP:0011472)2.65392395
55Aortic dissection (HP:0002647)2.63241951
56Abnormality of the distal phalanges of the toes (HP:0010182)2.62836765
57Hypoplasia of dental enamel (HP:0006297)2.62354731
58Abnormality of the salivary glands (HP:0010286)2.61259775
59Pustule (HP:0200039)2.60977652
60Ureteral stenosis (HP:0000071)2.60532922
61Ureteral obstruction (HP:0006000)2.58261407
62Erythroderma (HP:0001019)2.58154914
63Hyperaldosteronism (HP:0000859)2.57964544
64Hypoplastic labia majora (HP:0000059)2.55505436
65Exocrine pancreatic insufficiency (HP:0001738)2.55174832
66Abnormal biliary tract morphology (HP:0012440)2.51663377
67Abnormality of the proximal phalanges of the hand (HP:0009834)2.50385050
68Absent/shortened dynein arms (HP:0200106)2.47772785
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.47772785
70Shawl scrotum (HP:0000049)2.47183991
71Abnormality of the gastric mucosa (HP:0004295)2.45561445
72Hypomagnesemia (HP:0002917)2.43634678
73Abnormal blistering of the skin (HP:0008066)2.43232929
74Dehydration (HP:0001944)2.43159369
75Ectropion (HP:0000656)2.40604863
76Hypoplasia of the pons (HP:0012110)2.38002078
77Hyperphosphatemia (HP:0002905)2.35597519
78Ileus (HP:0002595)2.35198864
79Aplasia involving bones of the upper limbs (HP:0009823)2.34046919
80Aplasia of the phalanges of the hand (HP:0009802)2.34046919
81Aplasia involving bones of the extremities (HP:0009825)2.34046919
82Parakeratosis (HP:0001036)2.33893364
83Cardiovascular calcification (HP:0011915)2.32398580
84Sparse lateral eyebrow (HP:0005338)2.32135062
85Natal tooth (HP:0000695)2.31710425
86Intrahepatic cholestasis (HP:0001406)2.31541472
87Nasal polyposis (HP:0100582)2.31263908
88Abnormality of the dental root (HP:0006486)2.30550990
89Taurodontia (HP:0000679)2.30550990
90Abnormality of permanent molar morphology (HP:0011071)2.30550990
91Abnormal hemoglobin (HP:0011902)2.29478730
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27593334
93Abnormality of the labia majora (HP:0012881)2.27434078
94Conjugated hyperbilirubinemia (HP:0002908)2.26194090
95Amelogenesis imperfecta (HP:0000705)2.26181683
96Oligodontia (HP:0000677)2.25652222
97Absent eyelashes (HP:0000561)2.24014049
98Palmoplantar keratoderma (HP:0000982)2.23794826
99Short nail (HP:0001799)2.22938772
100Abnormal foot bone ossification (HP:0010675)2.20959614
101Aplasia/hypoplasia of the uterus (HP:0008684)2.20464964
102Esophageal varix (HP:0002040)2.20293695
103Cone-rod dystrophy (HP:0000548)2.19428163
104Ridged nail (HP:0001807)2.19419703
105Sparse scalp hair (HP:0002209)2.17752300
106Widely patent fontanelles and sutures (HP:0004492)2.17341613
107Germ cell neoplasia (HP:0100728)2.15710631
108Focal segmental glomerulosclerosis (HP:0000097)2.12554635
109Renal salt wasting (HP:0000127)2.11951390
110Gastrointestinal carcinoma (HP:0002672)2.11865695
111Malignant gastrointestinal tract tumors (HP:0006749)2.11865695
112Hypoplastic nipples (HP:0002557)2.11236292
113Hyponatremia (HP:0002902)2.11201323
114Palmoplantar hyperkeratosis (HP:0000972)2.11119871
115Abnormality of molar morphology (HP:0011070)2.09317084
116Abnormality of molar (HP:0011077)2.09317084
117Interstitial pulmonary disease (HP:0006530)2.07890367
118Abnormality of the dental pulp (HP:0006479)2.06915933
119Fibular aplasia (HP:0002990)2.06665497
120Hematochezia (HP:0002573)2.05783288
121Abnormality of the pons (HP:0007361)2.05029397
122Ankyloglossia (HP:0010296)2.04845218
123Septate vagina (HP:0001153)2.04609559
124Ventricular fibrillation (HP:0001663)2.04596734
125Popliteal pterygium (HP:0009756)2.04544253
126Abnormality of renal excretion (HP:0011036)2.04329533
127Nail dystrophy (HP:0008404)2.03527164
128Bronchitis (HP:0012387)2.03342472
129Short hallux (HP:0010109)2.03052514
130Abnormality of magnesium homeostasis (HP:0004921)2.02654103
131Blepharitis (HP:0000498)2.00839120
132Osteolytic defects of the hand bones (HP:0009699)2.00664197
133Osteolytic defects of the phalanges of the hand (HP:0009771)2.00664197
134Thrombocytosis (HP:0001894)1.96998730
135Malnutrition (HP:0004395)1.96521035
136Abnormality of the axillary hair (HP:0100134)1.95172134
137Abnormality of secondary sexual hair (HP:0009888)1.95172134
138Laryngomalacia (HP:0001601)1.95028849
139Fat malabsorption (HP:0002630)1.94913888
140Hypohidrosis (HP:0000966)1.94795590
141Glomerulosclerosis (HP:0000096)1.93113413
142Palmar hyperkeratosis (HP:0010765)1.92871648
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.92690635
144Absent hair (HP:0002298)1.92244655
145Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.92050480
146Hydroxyprolinuria (HP:0003080)1.91161723
147Abnormality of proline metabolism (HP:0010907)1.91161723
148Abnormal pancreas size (HP:0012094)1.90788814
149Aneurysm (HP:0002617)1.90263844
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90127444
151Abnormality of the nasal mucosa (HP:0000433)1.89844239
152Pterygium (HP:0001059)1.87682636
153Fragile skin (HP:0001030)1.87318992
154Alopecia of scalp (HP:0002293)1.86848549
155Uterine neoplasm (HP:0010784)1.86704921
156Metabolic alkalosis (HP:0200114)1.83047596
157Broad face (HP:0000283)1.82115552
158Mildly elevated creatine phosphokinase (HP:0008180)1.81371851
159Abnormality of the intrinsic pathway (HP:0010989)1.81209166
160Aplasia cutis congenita (HP:0001057)1.78807560
161Congenital sensorineural hearing impairment (HP:0008527)1.76691735
162Colon cancer (HP:0003003)1.76617624
163Aplasia/Hypoplasia of the hallux (HP:0008362)1.76205548
164Microretrognathia (HP:0000308)1.76153110
165Coxa valga (HP:0002673)1.73432040
166Hypoalbuminemia (HP:0003073)1.73380105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.55742582
2MST44.94575251
3AKT34.11395896
4LATS14.08717498
5EPHA23.70276275
6LMTK23.47595132
7TAOK33.41316377
8STK393.40919100
9EEF2K2.62573706
10SIK12.49573772
11ERN12.42413026
12STK242.23637367
13MST1R2.20819268
14NUAK12.17513551
15MAP3K22.05514776
16OXSR11.94303226
17FER1.87967530
18RPS6KB21.87336729
19PTK61.66304375
20STK38L1.66238468
21MAPKAPK31.64918978
22MYLK1.64879124
23PIK3CA1.56224206
24SCYL21.51085221
25MAPK151.47067472
26MAP3K121.46583672
27TRPM71.37914575
28CAMK1G1.36041824
29BRSK21.34816354
30PRKD31.33146824
31SMG11.27280434
32STK31.23982126
33MAP2K21.22167642
34PDK21.19938433
35STK101.19627826
36MAP3K91.18503817
37NME11.18028183
38PIK3CG1.15639705
39LRRK21.15475736
40CDK121.15068024
41ICK1.12596126
42BCKDK1.11951233
43TTN1.09550654
44TAOK11.08899474
45ERBB30.99391937
46RIPK10.97524753
47MET0.96608546
48DMPK0.87407310
49JAK30.87148632
50MAP3K30.85686197
51TESK10.79414752
52PTK20.78783619
53EIF2AK10.77989341
54WNK40.77228369
55PRKCI0.76852249
56EPHB10.72896043
57EPHB20.70048783
58ERBB20.63429966
59CDC42BPA0.63062936
60TRIB30.62267280
61CHUK0.61939519
62EPHA30.56692432
63WNK10.56485058
64EIF2AK30.52870134
65MELK0.50334075
66NEK90.49383625
67JAK10.49006676
68MAP2K60.48024203
69PRKD20.46869834
70FGFR20.45356336
71TYK20.44915171
72HIPK20.44755433
73BCR0.44619203
74PBK0.44081981
75MATK0.43698258
76RPS6KA20.43682829
77TGFBR10.43663519
78PRKAA20.43228533
79MAP3K80.42503536
80INSRR0.42381304
81PRKG20.42269067
82TNK20.42230252
83PKN20.41886858
84KSR20.41510167
85MAP3K70.41346282
86PDGFRA0.41226736
87JAK20.41010045
88GRK10.38958361
89MAP2K10.38834354
90ROCK10.38603181
91IRAK10.38336652
92MAP3K10.38322497
93PDK40.37856893
94PDK30.37856893
95SGK2230.37856881
96SGK4940.37856881
97LATS20.37103516
98TSSK60.36201980
99SGK20.36106391
100PAK40.35719451
101MAPKAPK50.35059870
102PDGFRB0.35027061
103MAP3K60.34329357
104ILK0.34174302
105AURKB0.33819681
106MAP3K140.33407679
107BMPR20.33309811
108BMX0.33180534
109DDR20.32508188
110STK380.32261429
111NLK0.31826236
112FGFR30.31590617
113MARK20.31420189
114TAF10.31045172
115PAK20.29854337
116YES10.28865272
117RET0.28730238
118PRKAA10.28702127
119FGFR40.27908323
120IRAK30.26922767
121ACVR1B0.26860126
122PIM20.25558075
123PAK30.25246196
124BRSK10.24911894
125CDK60.24899119
126CAMK1D0.23957860
127MAP3K130.23218669
128TBK10.22661122
129ABL20.22170350
130PRKCE0.21963679
131ROCK20.21918406
132BMPR1B0.21147781
133RPS6KA10.21141012
134SGK30.21123748
135CDK70.19004724
136TGFBR20.16991556
137MTOR0.16249874
138ERBB40.15817010
139NEK60.15750846
140CDK90.15578886
141IKBKE0.14343580

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.26817596
2Sulfur metabolism_Homo sapiens_hsa009204.22344130
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.22100878
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.19828540
5Phenylalanine metabolism_Homo sapiens_hsa003602.77425941
6Tight junction_Homo sapiens_hsa045302.24038207
7Protein export_Homo sapiens_hsa030602.16888592
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.16820610
9Adherens junction_Homo sapiens_hsa045202.15503605
10N-Glycan biosynthesis_Homo sapiens_hsa005102.11717884
11Vibrio cholerae infection_Homo sapiens_hsa051102.08017916
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.97504146
13Renin-angiotensin system_Homo sapiens_hsa046141.87475819
14Small cell lung cancer_Homo sapiens_hsa052221.81521800
15Other glycan degradation_Homo sapiens_hsa005111.80268223
16Circadian rhythm_Homo sapiens_hsa047101.78812987
17Endometrial cancer_Homo sapiens_hsa052131.70796124
18Bladder cancer_Homo sapiens_hsa052191.68644776
19ECM-receptor interaction_Homo sapiens_hsa045121.64022920
20Mineral absorption_Homo sapiens_hsa049781.61871959
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60278091
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.60057146
23Protein digestion and absorption_Homo sapiens_hsa049741.59211281
24Tyrosine metabolism_Homo sapiens_hsa003501.56869796
25Prostate cancer_Homo sapiens_hsa052151.54841465
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44505286
27Hepatitis C_Homo sapiens_hsa051601.42111594
28Chemical carcinogenesis_Homo sapiens_hsa052041.40802230
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.37092965
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35434349
31Arginine biosynthesis_Homo sapiens_hsa002201.33529124
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31492653
33Amoebiasis_Homo sapiens_hsa051461.30908648
34Pancreatic secretion_Homo sapiens_hsa049721.29672715
35Hippo signaling pathway_Homo sapiens_hsa043901.27655236
36Pancreatic cancer_Homo sapiens_hsa052121.27608295
37Retinol metabolism_Homo sapiens_hsa008301.27248682
38Focal adhesion_Homo sapiens_hsa045101.24826985
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.22440509
40Thyroid hormone synthesis_Homo sapiens_hsa049181.13472671
41Toxoplasmosis_Homo sapiens_hsa051451.13316865
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13040007
43Fructose and mannose metabolism_Homo sapiens_hsa000511.12029844
44Starch and sucrose metabolism_Homo sapiens_hsa005001.07180330
45Prolactin signaling pathway_Homo sapiens_hsa049171.07125137
46Thyroid cancer_Homo sapiens_hsa052161.04513693
47Fatty acid biosynthesis_Homo sapiens_hsa000610.99707998
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.96412474
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96224853
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95404480
51PPAR signaling pathway_Homo sapiens_hsa033200.94802720
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94364882
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93724385
54Inositol phosphate metabolism_Homo sapiens_hsa005620.92218206
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91474773
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89554232
57Vitamin digestion and absorption_Homo sapiens_hsa049770.87364765
58Ether lipid metabolism_Homo sapiens_hsa005650.87003411
59Proteoglycans in cancer_Homo sapiens_hsa052050.86486061
60TGF-beta signaling pathway_Homo sapiens_hsa043500.85835170
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80760405
62Chronic myeloid leukemia_Homo sapiens_hsa052200.79378973
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79058019
64Influenza A_Homo sapiens_hsa051640.78855556
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78082650
66Propanoate metabolism_Homo sapiens_hsa006400.77914794
67Melanoma_Homo sapiens_hsa052180.76890754
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75556100
69Fat digestion and absorption_Homo sapiens_hsa049750.75038656
70Fatty acid degradation_Homo sapiens_hsa000710.74647923
71Galactose metabolism_Homo sapiens_hsa000520.73853057
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73046628
73TNF signaling pathway_Homo sapiens_hsa046680.72342232
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71996745
75Insulin resistance_Homo sapiens_hsa049310.71933999
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71372112
77Arachidonic acid metabolism_Homo sapiens_hsa005900.71316035
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67604090
79Pathways in cancer_Homo sapiens_hsa052000.67350839
80Histidine metabolism_Homo sapiens_hsa003400.66243587
81Fatty acid metabolism_Homo sapiens_hsa012120.64730342
82Sphingolipid metabolism_Homo sapiens_hsa006000.62271414
83Gastric acid secretion_Homo sapiens_hsa049710.62140402
84Choline metabolism in cancer_Homo sapiens_hsa052310.62134472
85ABC transporters_Homo sapiens_hsa020100.62130718
86Notch signaling pathway_Homo sapiens_hsa043300.62075025
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62043058
88Tryptophan metabolism_Homo sapiens_hsa003800.61515755
89ErbB signaling pathway_Homo sapiens_hsa040120.61439980
90Non-small cell lung cancer_Homo sapiens_hsa052230.60078049
91Renal cell carcinoma_Homo sapiens_hsa052110.58308460
92Endocytosis_Homo sapiens_hsa041440.57271660
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.56818087
94Insulin signaling pathway_Homo sapiens_hsa049100.54058162
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52664839
96Caffeine metabolism_Homo sapiens_hsa002320.51758025
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51475526
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50486682
99VEGF signaling pathway_Homo sapiens_hsa043700.50480677
100Glutathione metabolism_Homo sapiens_hsa004800.48858576
101MicroRNAs in cancer_Homo sapiens_hsa052060.48704803
102Acute myeloid leukemia_Homo sapiens_hsa052210.47450411
103FoxO signaling pathway_Homo sapiens_hsa040680.47148811
104Linoleic acid metabolism_Homo sapiens_hsa005910.46293869
105mTOR signaling pathway_Homo sapiens_hsa041500.46200134
106Lysosome_Homo sapiens_hsa041420.45416693
107AMPK signaling pathway_Homo sapiens_hsa041520.45347028
108GnRH signaling pathway_Homo sapiens_hsa049120.45275682
109Peroxisome_Homo sapiens_hsa041460.44424925
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44007719
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43651776
112Glycerolipid metabolism_Homo sapiens_hsa005610.42439682
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41998730
114Salivary secretion_Homo sapiens_hsa049700.41931234
115Nitrogen metabolism_Homo sapiens_hsa009100.40797693
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40427777
117Glucagon signaling pathway_Homo sapiens_hsa049220.39496684
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38785275
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38672597
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38346398
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.38067413
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37132923
123Bile secretion_Homo sapiens_hsa049760.37042790
124Basal cell carcinoma_Homo sapiens_hsa052170.36401224
125Antigen processing and presentation_Homo sapiens_hsa046120.36311189
126Collecting duct acid secretion_Homo sapiens_hsa049660.35010433
127Arginine and proline metabolism_Homo sapiens_hsa003300.33812673
128Apoptosis_Homo sapiens_hsa042100.33611649
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.33413765
130Salmonella infection_Homo sapiens_hsa051320.33327208
131Estrogen signaling pathway_Homo sapiens_hsa049150.32989148
132Colorectal cancer_Homo sapiens_hsa052100.32115103
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32086051
134beta-Alanine metabolism_Homo sapiens_hsa004100.31521018
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31332541

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