EHHADH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.50243847
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.29525264
3L-phenylalanine catabolic process (GO:0006559)7.29525264
4omega-hydroxylase P450 pathway (GO:0097267)7.04373817
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.02213099
6L-phenylalanine metabolic process (GO:0006558)7.02213099
7aromatic amino acid family catabolic process (GO:0009074)6.65396562
8alpha-linolenic acid metabolic process (GO:0036109)6.18152311
9indole-containing compound catabolic process (GO:0042436)6.05358862
10indolalkylamine catabolic process (GO:0046218)6.05358862
11tryptophan catabolic process (GO:0006569)6.05358862
12fibrinolysis (GO:0042730)6.03737730
13glyoxylate metabolic process (GO:0046487)5.98808413
14kynurenine metabolic process (GO:0070189)5.91581656
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.79261636
16bile acid biosynthetic process (GO:0006699)5.77056324
17cysteine metabolic process (GO:0006534)5.74004422
18tryptophan metabolic process (GO:0006568)5.72676425
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.62557715
20oxidative demethylation (GO:0070989)5.56071741
21blood coagulation, intrinsic pathway (GO:0007597)5.46406705
22lysine catabolic process (GO:0006554)5.39879305
23lysine metabolic process (GO:0006553)5.39879305
24sulfur amino acid catabolic process (GO:0000098)5.33076120
25serine family amino acid catabolic process (GO:0009071)5.17767135
26urea metabolic process (GO:0019627)5.14932416
27urea cycle (GO:0000050)5.14932416
28phenylpropanoid metabolic process (GO:0009698)5.14051762
29amino-acid betaine metabolic process (GO:0006577)5.03623037
30ethanol metabolic process (GO:0006067)4.95672039
31homocysteine metabolic process (GO:0050667)4.93240281
32bile acid metabolic process (GO:0008206)4.93225712
33high-density lipoprotein particle remodeling (GO:0034375)4.92468207
34S-adenosylmethionine metabolic process (GO:0046500)4.87880109
35cellular ketone body metabolic process (GO:0046950)4.87173630
36aromatic amino acid family metabolic process (GO:0009072)4.85249883
37negative regulation of fibrinolysis (GO:0051918)4.84590557
38intestinal cholesterol absorption (GO:0030299)4.76641572
39nitrogen cycle metabolic process (GO:0071941)4.75737907
40protein carboxylation (GO:0018214)4.72482604
41peptidyl-glutamic acid carboxylation (GO:0017187)4.72482604
42regulation of plasminogen activation (GO:0010755)4.70479044
43regulation of fibrinolysis (GO:0051917)4.60629760
44alpha-amino acid catabolic process (GO:1901606)4.60580232
45negative regulation of hemostasis (GO:1900047)4.58132625
46negative regulation of blood coagulation (GO:0030195)4.58132625
47complement activation, alternative pathway (GO:0006957)4.54591723
48tyrosine metabolic process (GO:0006570)4.53612355
49drug transmembrane transport (GO:0006855)4.51391366
50regulation of triglyceride catabolic process (GO:0010896)4.49010423
51regulation of protein activation cascade (GO:2000257)4.45475577
52negative regulation of sterol transport (GO:0032372)4.42664327
53negative regulation of cholesterol transport (GO:0032375)4.42664327
54regulation of cholesterol esterification (GO:0010872)4.39548249
55reverse cholesterol transport (GO:0043691)4.33424585
56drug catabolic process (GO:0042737)4.33394031
57serine family amino acid metabolic process (GO:0009069)4.33289456
58cellular amino acid catabolic process (GO:0009063)4.32249041
59urate metabolic process (GO:0046415)4.31157893
60protein-lipid complex remodeling (GO:0034368)4.31121916
61macromolecular complex remodeling (GO:0034367)4.31121916
62plasma lipoprotein particle remodeling (GO:0034369)4.31121916
63glutamate metabolic process (GO:0006536)4.31000827
64indolalkylamine metabolic process (GO:0006586)4.30888003
65short-chain fatty acid metabolic process (GO:0046459)4.29670816
66very-low-density lipoprotein particle assembly (GO:0034379)4.27781821
67triglyceride homeostasis (GO:0070328)4.26753698
68acylglycerol homeostasis (GO:0055090)4.26753698
69flavonoid metabolic process (GO:0009812)4.25680110
70daunorubicin metabolic process (GO:0044597)4.23191509
71polyketide metabolic process (GO:0030638)4.23191509
72doxorubicin metabolic process (GO:0044598)4.23191509
73negative regulation of coagulation (GO:0050819)4.22591078
74ketone body metabolic process (GO:1902224)4.21943045
75cellular modified amino acid catabolic process (GO:0042219)4.20536457
76glycine metabolic process (GO:0006544)4.20199242
77negative regulation of protein activation cascade (GO:2000258)4.19057822
78protein activation cascade (GO:0072376)4.18427038
79coenzyme catabolic process (GO:0009109)4.16018836
80acetyl-CoA metabolic process (GO:0006084)4.15835549
81fat-soluble vitamin biosynthetic process (GO:0042362)4.15823125
82amine catabolic process (GO:0009310)4.15694870
83cellular biogenic amine catabolic process (GO:0042402)4.15694870
84regulation of complement activation (GO:0030449)4.14621253
85bile acid and bile salt transport (GO:0015721)4.14181150
86ethanol oxidation (GO:0006069)4.12621968
87benzene-containing compound metabolic process (GO:0042537)4.12600301
88phospholipid efflux (GO:0033700)4.12074098
89negative regulation of wound healing (GO:0061045)4.10349979
90plasma lipoprotein particle clearance (GO:0034381)4.05067358
91cellular glucuronidation (GO:0052695)4.03417469
92alkaloid metabolic process (GO:0009820)4.02459264
93aminoglycoside antibiotic metabolic process (GO:0030647)4.01557330
94serine family amino acid biosynthetic process (GO:0009070)4.01106967
95response to mercury ion (GO:0046689)4.00532007
96* fatty acid beta-oxidation (GO:0006635)3.96993170
97dicarboxylic acid biosynthetic process (GO:0043650)3.94650806
98negative regulation of lipase activity (GO:0060192)3.94132764
99aspartate family amino acid catabolic process (GO:0009068)3.93541967
100carnitine metabolic process (GO:0009437)3.92862529
101* organic acid catabolic process (GO:0016054)3.92142342
102* carboxylic acid catabolic process (GO:0046395)3.92142342
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.90160307
104* fatty acid oxidation (GO:0019395)3.89758357
105acute-phase response (GO:0006953)3.87505459
106cholesterol efflux (GO:0033344)3.84830475
107aldehyde catabolic process (GO:0046185)3.83508778
108regulation of cholesterol homeostasis (GO:2000188)3.82745937
109* lipid oxidation (GO:0034440)3.82232263
110positive regulation of blood coagulation (GO:0030194)3.81734947
111positive regulation of hemostasis (GO:1900048)3.81734947
1122-oxoglutarate metabolic process (GO:0006103)3.80901648
113* monocarboxylic acid catabolic process (GO:0072329)3.80613632
114complement activation, classical pathway (GO:0006958)3.79886764
115heme transport (GO:0015886)3.79575779
116regulation of humoral immune response (GO:0002920)3.78501414
117primary alcohol catabolic process (GO:0034310)3.77682873
118very long-chain fatty acid metabolic process (GO:0000038)3.76101824
119* fatty acid catabolic process (GO:0009062)3.76094668
120imidazole-containing compound metabolic process (GO:0052803)3.73582969
121hormone catabolic process (GO:0042447)3.73282116
122drug transport (GO:0015893)3.72976275
123complement activation (GO:0006956)3.71811139
124L-methionine salvage (GO:0071267)3.70920787
125L-methionine biosynthetic process (GO:0071265)3.70920787
126amino acid salvage (GO:0043102)3.70920787
127positive regulation of lipid catabolic process (GO:0050996)3.70184886
128low-density lipoprotein particle remodeling (GO:0034374)3.69734683
129plasma lipoprotein particle assembly (GO:0034377)3.69486146
130arginine metabolic process (GO:0006525)3.68748392
131phospholipid homeostasis (GO:0055091)3.68641343
132glucuronate metabolic process (GO:0019585)3.65741947
133uronic acid metabolic process (GO:0006063)3.65741947
134exogenous drug catabolic process (GO:0042738)3.63498716
135positive regulation of fatty acid beta-oxidation (GO:0032000)3.62635680
136xenobiotic metabolic process (GO:0006805)3.60116679
137cholesterol homeostasis (GO:0042632)3.57694579
138valine metabolic process (GO:0006573)3.56668985
139sterol homeostasis (GO:0055092)3.54307124
140drug metabolic process (GO:0017144)3.53550941
141positive regulation of coagulation (GO:0050820)3.51319133
142positive regulation of lipoprotein lipase activity (GO:0051006)3.49900175
143positive regulation of triglyceride lipase activity (GO:0061365)3.49900175
144sodium-independent organic anion transport (GO:0043252)3.49565952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.27491198
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11110377
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.49706875
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.43967463
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.26871615
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03140539
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65994189
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94114948
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.71894572
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33924576
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13478257
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09813518
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4988244
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97006058
15CLOCK_20551151_ChIP-Seq_293T_Human1.79530360
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71984191
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.66006074
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55982939
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.47146912
20GATA1_22025678_ChIP-Seq_K562_Human1.41022349
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.39084922
22IGF1R_20145208_ChIP-Seq_DFB_Human1.38467820
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36518631
24* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35311693
25HTT_18923047_ChIP-ChIP_STHdh_Human1.31253074
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.15481918
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12951824
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12938907
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12171251
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.10961378
31ER_23166858_ChIP-Seq_MCF-7_Human1.10578292
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08567398
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07394471
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06836781
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06335318
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05284678
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04219872
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03177385
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03160694
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.02496854
41HNFA_21074721_ChIP-Seq_CACO-2_Human1.01890313
42GATA4_25053715_ChIP-Seq_YYC3_Human1.00723958
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00032411
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99236101
45PHF8_20622853_ChIP-Seq_HELA_Human0.99189656
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97969009
47KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96675060
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95804976
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93914191
50ESR2_21235772_ChIP-Seq_MCF-7_Human0.91044174
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90922470
52ZNF263_19887448_ChIP-Seq_K562_Human0.88569679
53FLI1_27457419_Chip-Seq_LIVER_Mouse0.88442243
54OCT4_18555785_Chip-Seq_ESCs_Mouse0.87982650
55IRF1_19129219_ChIP-ChIP_H3396_Human0.87562779
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87374557
57TCF4_22108803_ChIP-Seq_LS180_Human0.87100959
58NFYA_21822215_ChIP-Seq_K562_Human0.86999278
59TP53_18474530_ChIP-ChIP_U2OS_Human0.86307661
60CRX_20693478_ChIP-Seq_RETINA_Mouse0.86232469
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86030676
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85446086
63STAT3_18555785_Chip-Seq_ESCs_Mouse0.85116387
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84903303
65CBP_20019798_ChIP-Seq_JUKART_Human0.84903303
66IRF8_22096565_ChIP-ChIP_GC-B_Human0.84417502
67PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84377304
68SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83731274
69* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83291010
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83040525
71ESR1_21235772_ChIP-Seq_MCF-7_Human0.82523091
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81698222
73NANOG_19829295_ChIP-Seq_ESCs_Human0.81473005
74SOX2_19829295_ChIP-Seq_ESCs_Human0.81473005
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80688843
76FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80669006
77* STAT3_23295773_ChIP-Seq_U87_Human0.79982833
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.79248594
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79141674
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78925154
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78851121
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.78662676
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78622999
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78483534
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77212757
86RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77021524
87SOX2_18555785_Chip-Seq_ESCs_Mouse0.76978791
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76643159
89GBX2_23144817_ChIP-Seq_PC3_Human0.76591543
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76588787
91CBX2_22325352_ChIP-Seq_293T-Rex_Human0.76251408
92ETV1_20927104_ChIP-Seq_GIST48_Human0.75971222
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.75872300
94ESRRB_18555785_Chip-Seq_ESCs_Mouse0.75509045
95KLF4_18555785_Chip-Seq_ESCs_Mouse0.74892949
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74692850
97P300_18555785_Chip-Seq_ESCs_Mouse0.74680871
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71888371
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71718781
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71109433
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71105859
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71105859
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70615543
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69758804
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69674855
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.67321233
107EGR1_19032775_ChIP-ChIP_M12_Human0.63600805
108* RARA_24833708_ChIP-Seq_LIVER_Mouse0.62878992
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62557623
110CEBPB_22108803_ChIP-Seq_LS180_Human0.62183204
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61618065
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61578323
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.61334813
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60946276
115LXR_22292898_ChIP-Seq_THP-1_Human0.60698343
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59245424
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.58240293
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57462044
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.56541303
120GATA6_25053715_ChIP-Seq_YYC3_Human0.55117074
121MYC_19915707_ChIP-ChIP_AK7_Human0.54441564
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.53608483
123ESET_19884257_ChIP-Seq_ESCs_Mouse0.53190316
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.53029130
125AR_20517297_ChIP-Seq_VCAP_Human0.52113255
126* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52004543
127CBP_21632823_ChIP-Seq_H3396_Human0.50661579
128GATA2_19941826_ChIP-Seq_K562_Human0.49977393
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49490689
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48861187
131STAT1_17558387_ChIP-Seq_HELA_Human0.48761032
132GATA1_19941826_ChIP-Seq_K562_Human0.48493553
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48129396
134SOX2_20726797_ChIP-Seq_SW620_Human0.45989489
135BCAT_22108803_ChIP-Seq_LS180_Human0.44691893
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.44316913
137P53_21459846_ChIP-Seq_SAOS-2_Human0.43199444
138TAF2_19829295_ChIP-Seq_ESCs_Human0.43154483
139CDX2_22108803_ChIP-Seq_LS180_Human0.43045968
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41493572
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41026464
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.40919033
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.40908885
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40643330
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39981707
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39916615
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.39710062
148TAF15_26573619_Chip-Seq_HEK293_Human0.39312877
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39005718
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38559514
151RACK7_27058665_Chip-Seq_MCF-7_Human0.37677995
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37135393
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.37028613
154P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36820813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.51183983
2MP0005360_urolithiasis7.63296035
3MP0005085_abnormal_gallbladder_physiolo6.18439168
4* MP0005365_abnormal_bile_salt5.84442223
5MP0008875_abnormal_xenobiotic_pharmacok4.92604791
6MP0003252_abnormal_bile_duct4.06456451
7MP0003806_abnormal_nucleotide_metabolis3.88982087
8MP0010329_abnormal_lipoprotein_level3.36342891
9MP0005332_abnormal_amino_acid3.14165912
10MP0003195_calcinosis2.96196398
11MP0005083_abnormal_biliary_tract2.95853256
12MP0009840_abnormal_foam_cell2.87022616
13MP0001666_abnormal_nutrient_absorption2.64295023
14MP0004019_abnormal_vitamin_homeostasis2.59926518
15MP0002138_abnormal_hepatobiliary_system2.38686941
16MP0003191_abnormal_cellular_cholesterol2.18468544
17* MP0002118_abnormal_lipid_homeostasis2.09068695
18* MP0000609_abnormal_liver_physiology2.05516338
19MP0005451_abnormal_body_composition1.99755574
20MP0005319_abnormal_enzyme/_coenzyme1.82395275
21MP0003868_abnormal_feces_composition1.76332569
22MP0009643_abnormal_urine_homeostasis1.67218029
23MP0005584_abnormal_enzyme/coenzyme_acti1.64530883
24MP0001764_abnormal_homeostasis1.58394075
25MP0003186_abnormal_redox_activity1.36569380
26MP0003011_delayed_dark_adaptation1.24380786
27MP0005636_abnormal_mineral_homeostasis1.24007078
28MP0009697_abnormal_copulation1.23450887
29MP0004043_abnormal_pH_regulation1.13615758
30MP0000598_abnormal_liver_morphology1.12162692
31MP0001756_abnormal_urination1.08015602
32MP0003656_abnormal_erythrocyte_physiolo1.06095010
33MP0003705_abnormal_hypodermis_morpholog1.02889162
34MP0009764_decreased_sensitivity_to1.01041673
35MP0005647_abnormal_sex_gland1.00103864
36MP0000604_amyloidosis0.98955414
37MP0006036_abnormal_mitochondrial_physio0.96680065
38MP0005084_abnormal_gallbladder_morpholo0.91861445
39MP0002876_abnormal_thyroid_physiology0.91828127
40MP0005670_abnormal_white_adipose0.91603940
41MP0009642_abnormal_blood_homeostasis0.88112804
42MP0009763_increased_sensitivity_to0.88056931
43MP0002136_abnormal_kidney_physiology0.87282016
44MP0002254_reproductive_system_inflammat0.85516001
45MP0008469_abnormal_protein_level0.83922519
46MP0002078_abnormal_glucose_homeostasis0.82582679
47MP0002132_abnormal_respiratory_system0.80132537
48MP0005535_abnormal_body_temperature0.78810392
49MP0005408_hypopigmentation0.76415142
50MP0005220_abnormal_exocrine_pancreas0.75556702
51MP0004130_abnormal_muscle_cell0.75489662
52MP0002971_abnormal_brown_adipose0.75095758
53MP0005376_homeostasis/metabolism_phenot0.73903676
54MP0001661_extended_life_span0.72883693
55MP0009780_abnormal_chondrocyte_physiolo0.71161609
56MP0009765_abnormal_xenobiotic_induced0.71126624
57MP0005334_abnormal_fat_pad0.70118419
58MP0001915_intracranial_hemorrhage0.68638566
59MP0001765_abnormal_ion_homeostasis0.67602361
60MP0005187_abnormal_penis_morphology0.67572684
61MP0010368_abnormal_lymphatic_system0.64542730
62MP0003329_amyloid_beta_deposits0.63016841
63MP0003690_abnormal_glial_cell0.62741335
64MP0005266_abnormal_metabolism0.62129283
65MP0002928_abnormal_bile_duct0.61999367
66MP0003879_abnormal_hair_cell0.61555920
67MP0005666_abnormal_adipose_tissue0.58167118
68MP0000230_abnormal_systemic_arterial0.56960361
69MP0002909_abnormal_adrenal_gland0.55358158
70MP0005448_abnormal_energy_balance0.54043281
71MP0005395_other_phenotype0.51124133
72MP0003638_abnormal_response/metabolism_0.51060314
73MP0009053_abnormal_anal_canal0.49619623
74MP0005058_abnormal_lysosome_morphology0.49453187
75MP0002282_abnormal_trachea_morphology0.47922770
76MP0002168_other_aberrant_phenotype0.47174978
77MP0002796_impaired_skin_barrier0.45570692
78MP0003953_abnormal_hormone_level0.45487380
79MP0003300_gastrointestinal_ulcer0.44958102
80MP0000639_abnormal_adrenal_gland0.44737667
81* MP0006035_abnormal_mitochondrial_morpho0.44071171
82MP0002837_dystrophic_cardiac_calcinosis0.43124213
83MP0001944_abnormal_pancreas_morphology0.41639975
84MP0003724_increased_susceptibility_to0.41317964
85MP0001881_abnormal_mammary_gland0.40714344
86MP0008874_decreased_physiological_sensi0.39440736
87MP0005464_abnormal_platelet_physiology0.39087902
88MP0005551_abnormal_eye_electrophysiolog0.38629182
89MP0005379_endocrine/exocrine_gland_phen0.37749611
90MP0010234_abnormal_vibrissa_follicle0.36703229
91MP0008873_increased_physiological_sensi0.36595194
92MP0005023_abnormal_wound_healing0.35886241
93MP0003075_altered_response_to0.35750346
94MP0000538_abnormal_urinary_bladder0.34895239
95MP0004272_abnormal_basement_membrane0.34739680
96MP0009115_abnormal_fat_cell0.34501426
97MP0003718_maternal_effect0.33884303
98MP0003950_abnormal_plasma_membrane0.33767352
99MP0008872_abnormal_physiological_respon0.33664228
100MP0005164_abnormal_response_to0.33463827
101MP0004264_abnormal_extraembryonic_tissu0.33299884
102MP0009672_abnormal_birth_weight0.32827931
103MP0002135_abnormal_kidney_morphology0.32607286
104MP0005166_decreased_susceptibility_to0.32391831
105MP0002090_abnormal_vision0.32201130
106MP0003890_abnormal_embryonic-extraembry0.31956064
107MP0003959_abnormal_lean_body0.31757456
108MP0008961_abnormal_basal_metabolism0.31682036
109MP0002822_catalepsy0.31348066
110MP0004782_abnormal_surfactant_physiolog0.31259345
111MP0002970_abnormal_white_adipose0.30854151
112MP0004147_increased_porphyrin_level0.30658946
113MP0003436_decreased_susceptibility_to0.28785157
114MP0006082_CNS_inflammation0.28605511
115MP0001845_abnormal_inflammatory_respons0.28248594
116MP0000566_synostosis0.28232671
117MP0005248_abnormal_Harderian_gland0.27853823
118MP0001324_abnormal_eye_pigmentation0.27300489
119MP0001853_heart_inflammation0.26912931
120MP0003941_abnormal_skin_development0.26497342
121MP0003943_abnormal_hepatobiliary_system0.25433763
122MP0004883_abnormal_blood_vessel0.25380173
123MP0005646_abnormal_pituitary_gland0.24784742
124MP0005197_abnormal_uvea_morphology0.24536836
125MP0005330_cardiomyopathy0.24499162
126MP0008775_abnormal_heart_ventricle0.24434988

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.79737609
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.79540658
3Deep venous thrombosis (HP:0002625)6.36574358
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.05169515
5Xanthomatosis (HP:0000991)6.00733122
6Hypobetalipoproteinemia (HP:0003563)5.86895551
7Prolonged partial thromboplastin time (HP:0003645)5.45116439
8Hyperlipoproteinemia (HP:0010980)4.85727014
9Hyperammonemia (HP:0001987)4.71939710
10Hyperglycinuria (HP:0003108)4.67846385
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.61790289
12Ketosis (HP:0001946)4.58753805
13Hyperglycinemia (HP:0002154)4.58263874
14Abnormality of glycine metabolism (HP:0010895)4.46222702
15Abnormality of serine family amino acid metabolism (HP:0010894)4.46222702
16Epidermoid cyst (HP:0200040)4.37040265
17Hypolipoproteinemia (HP:0010981)4.32680335
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.31979991
19Complement deficiency (HP:0004431)4.28364907
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.20494248
21Joint hemorrhage (HP:0005261)4.12156084
22Hypoglycemic coma (HP:0001325)3.99813822
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.96056439
24Fat malabsorption (HP:0002630)3.95264690
25Abnormality of fatty-acid metabolism (HP:0004359)3.94965870
26Abnormality of methionine metabolism (HP:0010901)3.82052428
27Abnormality of the common coagulation pathway (HP:0010990)3.76796344
28Hypoalphalipoproteinemia (HP:0003233)3.70012652
29Ketoacidosis (HP:0001993)3.69274683
30Conjugated hyperbilirubinemia (HP:0002908)3.55838677
31Gout (HP:0001997)3.54235010
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47971919
33Nephritis (HP:0000123)3.42548189
34Abnormality of pyrimidine metabolism (HP:0004353)3.39479114
35Hypercholesterolemia (HP:0003124)3.39131934
36Abnormality of nucleobase metabolism (HP:0010932)3.35644902
37Abnormality of purine metabolism (HP:0004352)3.33727796
38Delayed CNS myelination (HP:0002188)3.32814042
39Hyperbilirubinemia (HP:0002904)3.20012165
40Abnormality of the intrinsic pathway (HP:0010989)3.17749993
41Abnormality of serum amino acid levels (HP:0003112)3.10690455
42Abnormality of complement system (HP:0005339)3.06153899
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04709367
44Dicarboxylic aciduria (HP:0003215)3.04709367
45Recurrent gram-negative bacterial infections (HP:0005420)2.98346656
46Osteomalacia (HP:0002749)2.97887871
47* Metabolic acidosis (HP:0001942)2.92416386
48Hepatocellular carcinoma (HP:0001402)2.87400073
49Steatorrhea (HP:0002570)2.87121302
50Proximal tubulopathy (HP:0000114)2.78895814
51Generalized aminoaciduria (HP:0002909)2.78758558
52Lethargy (HP:0001254)2.78752282
53Gingival bleeding (HP:0000225)2.76051182
54Vascular calcification (HP:0004934)2.73942851
55Skin nodule (HP:0200036)2.68746943
56Malnutrition (HP:0004395)2.63559881
57Alkalosis (HP:0001948)2.58370098
58Increased purine levels (HP:0004368)2.57166340
59Hyperuricemia (HP:0002149)2.57166340
60Spastic diplegia (HP:0001264)2.56641199
61Acanthocytosis (HP:0001927)2.56186776
62Myocardial infarction (HP:0001658)2.53102976
63Hemorrhage of the eye (HP:0011885)2.51573981
64Irritability (HP:0000737)2.45706729
65Cardiovascular calcification (HP:0011915)2.43053670
66Hypoglycemic seizures (HP:0002173)2.42664325
67Fair hair (HP:0002286)2.41423327
68Vomiting (HP:0002013)2.38706130
69Cerebral edema (HP:0002181)2.38648363
70Hypochromic microcytic anemia (HP:0004840)2.37706607
71Hydroxyprolinuria (HP:0003080)2.36426603
72Abnormality of proline metabolism (HP:0010907)2.36426603
73Neonatal onset (HP:0003623)2.35965185
74Reduced antithrombin III activity (HP:0001976)2.34573060
75Sensorimotor neuropathy (HP:0007141)2.34183294
76Spontaneous abortion (HP:0005268)2.33766476
77Enlarged kidneys (HP:0000105)2.29001125
78Systemic lupus erythematosus (HP:0002725)2.26155627
79Abnormal gallbladder morphology (HP:0012437)2.25756075
80Pancreatitis (HP:0001733)2.20957925
81Cholelithiasis (HP:0001081)2.19703963
82Abnormal gallbladder physiology (HP:0012438)2.18622741
83Cholecystitis (HP:0001082)2.18622741
84Potter facies (HP:0002009)2.18307578
85Facial shape deformation (HP:0011334)2.18307578
86Late onset (HP:0003584)2.18236788
87Thrombophlebitis (HP:0004418)2.17813132
88Brushfield spots (HP:0001088)2.12892284
89Mitral stenosis (HP:0001718)2.11801741
90Esophageal varix (HP:0002040)2.07369851
91Arthropathy (HP:0003040)2.07013250
92Abnormal enzyme/coenzyme activity (HP:0012379)2.06363816
93Renal cortical cysts (HP:0000803)2.05127564
94Glomerulonephritis (HP:0000099)2.05079184
95* Glycosuria (HP:0003076)2.02186113
96* Abnormality of urine glucose concentration (HP:0011016)2.02186113
97Abnormal cartilage morphology (HP:0002763)2.01383840
98Purpura (HP:0000979)1.98722412
99Hyperinsulinemic hypoglycemia (HP:0000825)1.97020434
100Opisthotonus (HP:0002179)1.92538288
101* Hyperphosphaturia (HP:0003109)1.91561438
102Amyloidosis (HP:0011034)1.89787383
103Bifid scrotum (HP:0000048)1.89663013
104Nausea (HP:0002018)1.89422157
105Confusion (HP:0001289)1.89223077
106* Rickets (HP:0002748)1.89053587
107Abnormality of the gallbladder (HP:0005264)1.87810860
108Abnormality of vitamin metabolism (HP:0100508)1.86672346
109Poikilocytosis (HP:0004447)1.85871925
110Menorrhagia (HP:0000132)1.84612386
111Increased serum pyruvate (HP:0003542)1.84446552
112Nephrolithiasis (HP:0000787)1.83950414
113Elevated hepatic transaminases (HP:0002910)1.82262461
114Abnormal biliary tract physiology (HP:0012439)1.82055821
115Bile duct proliferation (HP:0001408)1.82055821
116Abnormality of alkaline phosphatase activity (HP:0004379)1.81554301
117Hypophosphatemic rickets (HP:0004912)1.80738931
118Joint swelling (HP:0001386)1.80377879
119Retinal atrophy (HP:0001105)1.75930759
120Pulmonary embolism (HP:0002204)1.72307427
121Elevated alkaline phosphatase (HP:0003155)1.69495930
122Abnormal tarsal ossification (HP:0008369)1.68664191
123Generalized hypopigmentation of hair (HP:0011358)1.66048805
124Cerebral palsy (HP:0100021)1.65330867
125Increased mean platelet volume (HP:0011877)1.65273031
126Abnormality of transition element cation homeostasis (HP:0011030)1.60329238
127Abnormality of glycolysis (HP:0004366)1.59218302
128Hypothermia (HP:0002045)1.58993736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.20700303
2SIK13.97169506
3FGFR43.89994071
4ERN13.80100392
5INSRR2.89976091
6ACVR1B2.67234997
7WNK32.66555459
8WNK42.47538778
9TAOK32.41270812
10MST1R2.37035819
11PIK3CA2.31468406
12ERBB42.29146753
13PKN22.20974087
14OXSR12.18874511
15MAP3K122.05166071
16MAP2K41.91436266
17PIK3CG1.89408517
18TRIB31.71430940
19FLT31.69805690
20MAPK111.69313110
21EIF2AK31.66122850
22FRK1.60898685
23MYLK1.59200917
24FER1.56618090
25LATS11.52695490
26STK38L1.46499056
27BCR1.41619729
28ABL21.39486182
29PTK61.39271583
30BRSK21.38714507
31TYK21.38025135
32NLK1.36565032
33MST41.35316002
34MAP3K71.31846699
35PINK11.31530483
36AKT31.31135185
37DAPK21.30310460
38NEK91.28898391
39MAPKAPK31.28437890
40PRKAA21.25805283
41FGFR21.22546592
42BMPR1B1.22094014
43EIF2AK11.21409543
44KDR1.16959754
45PDK41.13505412
46PDK31.13505412
47GRK61.10446018
48JAK21.08159496
49CASK1.05009902
50MAP3K101.04012283
51TNIK1.02220797
52MAP3K41.01376829
53NTRK31.00291034
54MAP4K20.99742917
55CAMK1D0.98327598
56PBK0.97060050
57MET0.93299688
58ERBB30.92888255
59MAP3K140.92673602
60EPHB10.91853710
61PRKCE0.90908645
62MAP3K30.89722627
63TBK10.87761619
64MAP2K30.87318148
65SGK30.86851853
66SGK2230.86479726
67SGK4940.86479726
68MAPK40.85760591
69TIE10.85139402
70PRKCZ0.84859282
71TRIM280.84717134
72JAK10.84308217
73STK390.83406145
74PRKAA10.82826362
75GSK3A0.82365851
76MAPK150.80385717
77TRPM70.78976254
78ERBB20.77618075
79STK30.75159696
80IRAK30.74159448
81PRKACG0.72470614
82DYRK1B0.72263179
83CAMKK20.71756028
84SGK20.70416335
85RIPK10.69350134
86TGFBR20.69324829
87PRKG10.68344676
88MUSK0.68046846
89PDPK10.67757239
90MAPK120.67575103
91PDK20.65572536
92PRKACA0.63272969
93CSK0.62660853
94CDK60.61933424
95SCYL20.61405244
96PTK20.60390589
97NUAK10.59149501
98MAP3K110.56749926
99CSNK1E0.55724085
100PRKACB0.54774559
101CAMK1G0.53960474
102FGFR10.51218099
103CAMK2G0.50707202
104NEK10.50373517
105MAP2K60.48448361
106PDK10.48244630
107CSNK1D0.47641914
108PRKCQ0.47250531
109FGFR30.46927359
110PRKCB0.45830280
111EPHA20.45536119
112MAP2K70.44374113
113CSNK1G10.43741788
114CSNK1A10.43486935
115CSF1R0.41801538
116IGF1R0.41657213
117ADRBK20.41533207
118EPHA30.40825168
119ZAK0.40607535
120MAPK70.37665541
121CAMK2D0.37608885
122RET0.37339016
123RPS6KA30.36970359
124CSNK2A20.35478407
125MTOR0.34420856
126MAP2K10.34025718
127STK380.34020320
128IKBKE0.32216737
129ICK0.32042804
130MAP3K130.31500233
131GRK10.30951135
132PAK30.29411750
133MAP3K50.28284938
134IRAK20.26860640
135MAP3K20.26627134
136EGFR0.24885475
137PRKCA0.24862525
138CAMK40.24217174
139PRKCG0.23575609
140CDK40.23173139
141MAP2K20.22748882
142MAP3K60.22017282
143BMX0.21868177
144LRRK20.20219408

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15032824
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45229085
3Nitrogen metabolism_Homo sapiens_hsa009103.24671171
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08755986
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.07905800
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78205975
7Arginine biosynthesis_Homo sapiens_hsa002202.74671598
8* Fatty acid degradation_Homo sapiens_hsa000712.73517576
9* Tryptophan metabolism_Homo sapiens_hsa003802.66322540
10* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64817000
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44017618
12* Butanoate metabolism_Homo sapiens_hsa006502.38769397
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37110794
14* Peroxisome_Homo sapiens_hsa041462.28130507
15Complement and coagulation cascades_Homo sapiens_hsa046102.24750351
16* Propanoate metabolism_Homo sapiens_hsa006402.22380107
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06712992
18* Fatty acid metabolism_Homo sapiens_hsa012122.04564840
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98524649
20* PPAR signaling pathway_Homo sapiens_hsa033201.96988945
21Histidine metabolism_Homo sapiens_hsa003401.82782624
22Chemical carcinogenesis_Homo sapiens_hsa052041.77869650
23* beta-Alanine metabolism_Homo sapiens_hsa004101.76726283
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76382339
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74520939
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72297335
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.68199294
28Pyruvate metabolism_Homo sapiens_hsa006201.67640152
29Fatty acid elongation_Homo sapiens_hsa000621.61406213
30Retinol metabolism_Homo sapiens_hsa008301.59330203
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59272412
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.58663212
33Bile secretion_Homo sapiens_hsa049761.58453782
34Selenocompound metabolism_Homo sapiens_hsa004501.49208999
35Phenylalanine metabolism_Homo sapiens_hsa003601.43152820
36Sulfur metabolism_Homo sapiens_hsa009201.42531315
37Caffeine metabolism_Homo sapiens_hsa002321.41084763
38Staphylococcus aureus infection_Homo sapiens_hsa051501.37912503
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.31213414
40Starch and sucrose metabolism_Homo sapiens_hsa005001.28952897
41Tyrosine metabolism_Homo sapiens_hsa003501.26916504
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25667092
43* Carbon metabolism_Homo sapiens_hsa012001.23756532
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.21819085
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20885740
46ABC transporters_Homo sapiens_hsa020101.19732940
47Folate biosynthesis_Homo sapiens_hsa007901.19250901
48Fat digestion and absorption_Homo sapiens_hsa049751.19235171
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17367889
50Biosynthesis of amino acids_Homo sapiens_hsa012301.16148240
51Steroid biosynthesis_Homo sapiens_hsa001001.14792132
52Vitamin digestion and absorption_Homo sapiens_hsa049771.11868504
53Arginine and proline metabolism_Homo sapiens_hsa003301.02972742
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.96429315
55* Lysine degradation_Homo sapiens_hsa003100.87649418
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87610353
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86549701
58Glycerolipid metabolism_Homo sapiens_hsa005610.84003372
59Sulfur relay system_Homo sapiens_hsa041220.83093051
60Glutathione metabolism_Homo sapiens_hsa004800.80708781
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79873891
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78907950
63Vitamin B6 metabolism_Homo sapiens_hsa007500.78412400
64Fatty acid biosynthesis_Homo sapiens_hsa000610.68780194
65Pentose phosphate pathway_Homo sapiens_hsa000300.59791239
66One carbon pool by folate_Homo sapiens_hsa006700.58777750
67* Metabolic pathways_Homo sapiens_hsa011000.48084062
68Fructose and mannose metabolism_Homo sapiens_hsa000510.32275325
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32177761
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28836403
71Galactose metabolism_Homo sapiens_hsa000520.27607934
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27523483
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.27149413
74Insulin resistance_Homo sapiens_hsa049310.24783167
75Prion diseases_Homo sapiens_hsa050200.14187307
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.13756937
77Pertussis_Homo sapiens_hsa051330.11178792
78Linoleic acid metabolism_Homo sapiens_hsa005910.10681690
79Glucagon signaling pathway_Homo sapiens_hsa049220.10174205
80AMPK signaling pathway_Homo sapiens_hsa041520.05657715
81Sphingolipid metabolism_Homo sapiens_hsa006000.04992544
82N-Glycan biosynthesis_Homo sapiens_hsa005100.00731021
83Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2290617
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2254898
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2174361
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2124252
87African trypanosomiasis_Homo sapiens_hsa05143-0.2044593
88Other glycan degradation_Homo sapiens_hsa00511-0.1971812
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1924545
90Lysosome_Homo sapiens_hsa04142-0.1920949
91Protein export_Homo sapiens_hsa03060-0.1916042
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1783623
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1693833
94Hepatitis C_Homo sapiens_hsa05160-0.1623401
95Regulation of autophagy_Homo sapiens_hsa04140-0.1480000
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1415117
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1138315
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1094841
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1075091
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1053685
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1017555
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0911332
103Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0890006
104Mineral absorption_Homo sapiens_hsa04978-0.0881795
105Protein digestion and absorption_Homo sapiens_hsa04974-0.0762016
106Circadian rhythm_Homo sapiens_hsa04710-0.0753185
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0571409
108Serotonergic synapse_Homo sapiens_hsa04726-0.0397810
109Ether lipid metabolism_Homo sapiens_hsa00565-0.0285027
110Renin-angiotensin system_Homo sapiens_hsa04614-0.0099129
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0045930

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