EHMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.37142584
2regulation of gene silencing by RNA (GO:0060966)4.59630580
3regulation of posttranscriptional gene silencing (GO:0060147)4.59630580
4regulation of gene silencing by miRNA (GO:0060964)4.59630580
5DNA unwinding involved in DNA replication (GO:0006268)4.45493488
6B cell receptor signaling pathway (GO:0050853)4.03325033
7positive thymic T cell selection (GO:0045059)3.95253904
8thymic T cell selection (GO:0045061)3.75329226
9positive regulation of gene expression, epigenetic (GO:0045815)3.70569997
10pre-miRNA processing (GO:0031054)3.69087343
11histone H3-K4 methylation (GO:0051568)3.66892050
12negative thymic T cell selection (GO:0045060)3.61963156
13positive regulation of histone deacetylation (GO:0031065)3.61033665
14regulation of gamma-delta T cell differentiation (GO:0045586)3.58249366
15kinetochore organization (GO:0051383)3.57119306
16mitotic sister chromatid cohesion (GO:0007064)3.56682415
17histone H2A acetylation (GO:0043968)3.52317772
18* histone lysine methylation (GO:0034968)3.48520247
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45405705
20mRNA splice site selection (GO:0006376)3.44433278
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.43923418
22histone lysine demethylation (GO:0070076)3.40586086
23regulation of B cell receptor signaling pathway (GO:0050855)3.39579370
24positive regulation of gamma-delta T cell activation (GO:0046645)3.39147689
25negative T cell selection (GO:0043383)3.38983617
26paraxial mesoderm development (GO:0048339)3.37646807
27intracellular estrogen receptor signaling pathway (GO:0030520)3.37453555
28* histone H3-K9 modification (GO:0061647)3.36217839
29positive T cell selection (GO:0043368)3.35961871
30regulation of RNA export from nucleus (GO:0046831)3.35577019
31glucocorticoid receptor signaling pathway (GO:0042921)3.35454290
32negative regulation of RNA splicing (GO:0033119)3.34848402
33regulation of histone H3-K27 methylation (GO:0061085)3.34427389
34regulation of gamma-delta T cell activation (GO:0046643)3.34267805
35kinetochore assembly (GO:0051382)3.33409414
36positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.31561415
37histone demethylation (GO:0016577)3.29317659
38nuclear pore complex assembly (GO:0051292)3.29163052
39regulation of hippo signaling (GO:0035330)3.28581288
40chromatin silencing (GO:0006342)3.28366473
41regulation of histone methylation (GO:0031060)3.27991091
42positive regulation by host of viral transcription (GO:0043923)3.27931210
43interkinetic nuclear migration (GO:0022027)3.24941181
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24673292
45nuclear pore organization (GO:0006999)3.24152216
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18403970
47protein-DNA complex disassembly (GO:0032986)3.17343716
48nucleosome disassembly (GO:0006337)3.17343716
49dosage compensation (GO:0007549)3.16776039
50regulation of gene silencing (GO:0060968)3.16618056
51negative regulation of gene expression, epigenetic (GO:0045814)3.15850689
52positive regulation of protein deacetylation (GO:0090312)3.14851284
53* DNA alkylation (GO:0006305)3.11984554
54* DNA methylation (GO:0006306)3.11984554
55* histone methylation (GO:0016571)3.08796528
56negative regulation of histone modification (GO:0031057)3.08535051
57T cell selection (GO:0045058)3.08237974
58negative regulation of mRNA processing (GO:0050686)3.07399931
59DNA strand elongation involved in DNA replication (GO:0006271)3.07346804
60DNA topological change (GO:0006265)3.06789331
61snRNA metabolic process (GO:0016073)3.06785658
62ribosomal small subunit assembly (GO:0000028)3.05499686
63alternative mRNA splicing, via spliceosome (GO:0000380)3.03964451
64regulation of histone H3-K9 methylation (GO:0051570)3.00880774
65regulation of DNA endoreduplication (GO:0032875)3.00449305
66snRNA processing (GO:0016180)3.00399854
67protein localization to kinetochore (GO:0034501)3.00072798
68protein K48-linked deubiquitination (GO:0071108)2.99053851
69negative regulation of chromatin modification (GO:1903309)2.99035507
70DNA replication initiation (GO:0006270)2.98325934
71DNA strand elongation (GO:0022616)2.97728777
72positive regulation of CREB transcription factor activity (GO:0032793)2.96799891
73regulation of chromatin binding (GO:0035561)2.96576889
74RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.95473306
75mRNA splicing, via spliceosome (GO:0000398)2.95473306
76viral mRNA export from host cell nucleus (GO:0046784)2.94635942
77RNA splicing, via transesterification reactions (GO:0000375)2.94210217
78* histone H3-K9 methylation (GO:0051567)2.93615908
79corticosteroid receptor signaling pathway (GO:0031958)2.91437333
80heterochromatin organization (GO:0070828)2.91217003
81protein dealkylation (GO:0008214)2.91117719
82protein demethylation (GO:0006482)2.91117719
83* peptidyl-lysine methylation (GO:0018022)2.90485251
84gene silencing (GO:0016458)2.90472610
85DNA duplex unwinding (GO:0032508)2.87021983
86termination of RNA polymerase II transcription (GO:0006369)2.86930753
87DNA geometric change (GO:0032392)2.86310510
88mitotic recombination (GO:0006312)2.85872701
89positive regulation of histone H3-K4 methylation (GO:0051571)2.85777058
90monoubiquitinated protein deubiquitination (GO:0035520)2.84886008
91positive regulation of DNA-dependent DNA replication (GO:2000105)2.83675881
92mucosal-associated lymphoid tissue development (GO:0048537)2.82645529
93Peyers patch development (GO:0048541)2.82645529
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.81635950
95chromatin assembly (GO:0031497)2.78490483
96peptidyl-lysine trimethylation (GO:0018023)2.77978360
97mannose metabolic process (GO:0006013)2.76786181
98telomere maintenance via semi-conservative replication (GO:0032201)2.75783360
99histone H3-K4 trimethylation (GO:0080182)2.72983706
100mismatch repair (GO:0006298)2.72960861
101negative regulation of histone methylation (GO:0031061)2.72425280
102CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72353380
103intra-S DNA damage checkpoint (GO:0031573)2.72310279
104histone H4-K16 acetylation (GO:0043984)2.70223501
105regulation of chromatin silencing (GO:0031935)2.69994356
106lateral sprouting from an epithelium (GO:0060601)2.68858507
107regulation of DNA damage checkpoint (GO:2000001)2.68214176
108RNA export from nucleus (GO:0006405)2.68130155
109DNA double-strand break processing (GO:0000729)2.67941804
110mitotic chromosome condensation (GO:0007076)2.67851241
111ATP-dependent chromatin remodeling (GO:0043044)2.67420963
112cellular response to exogenous dsRNA (GO:0071360)2.66977776
113peptidyl-arginine omega-N-methylation (GO:0035247)2.66463334
114histone H4 deacetylation (GO:0070933)2.66374083
115negative regulation of myotube differentiation (GO:0010832)2.65824301
116histone H3 deacetylation (GO:0070932)2.65360870
117positive regulation of developmental pigmentation (GO:0048087)2.65084358
118limb bud formation (GO:0060174)2.64884210
119mRNA export from nucleus (GO:0006406)2.64496744
120spliceosomal complex assembly (GO:0000245)2.64347812
121* regulation of gene expression, epigenetic (GO:0040029)2.62277333
122DNA replication-independent nucleosome assembly (GO:0006336)2.61876239
123DNA replication-independent nucleosome organization (GO:0034724)2.61876239
124insulin-like growth factor receptor signaling pathway (GO:0048009)2.61727030
125telomere maintenance via recombination (GO:0000722)2.61511198
126regulation of mRNA splicing, via spliceosome (GO:0048024)2.60428484
127mitotic metaphase plate congression (GO:0007080)2.59983681
128microtubule depolymerization (GO:0007019)2.59006900
129sister chromatid segregation (GO:0000819)2.57766494
130snRNA transcription (GO:0009301)2.57048590
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56257007
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55540544
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.55540544
134regulation of translation, ncRNA-mediated (GO:0045974)2.55540544
135maturation of SSU-rRNA (GO:0030490)2.55329769
136telomere maintenance via telomere lengthening (GO:0010833)2.55257780
137DNA replication checkpoint (GO:0000076)2.55143822
138regulation of NFAT protein import into nucleus (GO:0051532)2.55103936
139positive regulation of RNA splicing (GO:0033120)2.54089496
140regulation of B cell differentiation (GO:0045577)2.53635794
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.53576707
142negative regulation of cell size (GO:0045792)2.52819136
143spindle checkpoint (GO:0031577)2.52598651
144CENP-A containing nucleosome assembly (GO:0034080)2.52176518
145gene silencing by RNA (GO:0031047)2.51754866
146chromatin remodeling at centromere (GO:0031055)2.51578434
147spindle assembly checkpoint (GO:0071173)2.51539001
148cytoplasmic mRNA processing body assembly (GO:0033962)2.51239364
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.50627317
150B cell homeostasis (GO:0001782)2.50075195
151regulation of nucleobase-containing compound transport (GO:0032239)2.49792489
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49357274
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49357274
154negative regulation of sister chromatid segregation (GO:0033046)2.49357274
155negative regulation of mitotic sister chromatid separation (GO:2000816)2.49357274
156T cell lineage commitment (GO:0002360)2.49214341
157protein deacetylation (GO:0006476)2.49053744
158poly(A)+ mRNA export from nucleus (GO:0016973)2.48808488
159regulation of sister chromatid cohesion (GO:0007063)2.48805452
160face development (GO:0060324)2.48746684
1613-UTR-mediated mRNA stabilization (GO:0070935)2.48713056
162negative regulation of chromosome segregation (GO:0051985)2.48248220
163regulation of telomere maintenance via telomerase (GO:0032210)2.48098263
164negative regulation of mRNA metabolic process (GO:1903312)2.48029560
165positive regulation of cell cycle G2/M phase transition (GO:1902751)2.47801185
166positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.47801185
167mitotic spindle assembly checkpoint (GO:0007094)2.47748921
168histone mRNA metabolic process (GO:0008334)2.47258446
169mitotic spindle checkpoint (GO:0071174)2.46944195
170DNA ligation (GO:0006266)2.46490382
171mitotic nuclear envelope disassembly (GO:0007077)2.45290698
172metaphase plate congression (GO:0051310)2.43380470
173histone arginine methylation (GO:0034969)2.43052610
174negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42657317
175base-excision repair (GO:0006284)2.42373613
176regulation of histone H3-K4 methylation (GO:0051569)2.41430170
177pore complex assembly (GO:0046931)2.41140488
178positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.40172133
179regulation of mitotic metaphase/anaphase transition (GO:0030071)2.40103471
180DNA replication-dependent nucleosome assembly (GO:0006335)2.39503942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.93463488
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59772722
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.47973617
4TP63_19390658_ChIP-ChIP_HaCaT_Human4.17161294
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.80783200
6VDR_21846776_ChIP-Seq_THP-1_Human3.53671518
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.48844966
8* MYC_18555785_ChIP-Seq_MESCs_Mouse3.15187507
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.13017460
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.12403785
11TCF7_22412390_ChIP-Seq_EML_Mouse2.86514866
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.79070694
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.76874106
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73196918
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.59045276
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.58612574
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.57081094
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52561396
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.50509245
20SCL_19346495_ChIP-Seq_HPC-7_Human2.43931277
21KDM2B_26808549_Chip-Seq_DND41_Human2.40888440
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.40132250
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38808212
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33698789
25CIITA_25753668_ChIP-Seq_RAJI_Human2.27902687
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23599457
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18457019
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.15277196
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14599642
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13980293
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13438040
32MAF_26560356_Chip-Seq_TH1_Human2.12234231
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11452308
34UTX_26944678_Chip-Seq_JUKART_Human2.08069530
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06465763
36SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03250000
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95962362
38VDR_24763502_ChIP-Seq_THP-1_Human1.91116115
39DROSHA_22980978_ChIP-Seq_HELA_Human1.88557789
40LXR_22292898_ChIP-Seq_THP-1_Human1.87356803
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86992234
42MAF_26560356_Chip-Seq_TH2_Human1.83267546
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.83062197
44* XRN2_22483619_ChIP-Seq_HELA_Human1.79948727
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79833163
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79178085
47MYC_22102868_ChIP-Seq_BL_Human1.76179901
48P68_20966046_ChIP-Seq_HELA_Human1.75617072
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74898189
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.74719337
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71748733
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69075021
53TTF2_22483619_ChIP-Seq_HELA_Human1.69066189
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67029239
55MYB_26560356_Chip-Seq_TH1_Human1.62887477
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.62565093
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62167753
58* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62051191
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.59025444
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56916903
61ELK1_19687146_ChIP-ChIP_HELA_Human1.56879176
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.56691528
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56556717
64SMC4_20622854_ChIP-Seq_HELA_Human1.55518913
65AR_21909140_ChIP-Seq_LNCAP_Human1.52756379
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51235917
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51037632
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45054362
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44688022
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43420631
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41953796
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40568131
73EWS_26573619_Chip-Seq_HEK293_Human1.39625192
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39390659
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39390659
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39390659
77KDM2B_26808549_Chip-Seq_K562_Human1.38878196
78MYB_26560356_Chip-Seq_TH2_Human1.38561675
79RACK7_27058665_Chip-Seq_MCF-7_Human1.38227983
80FOXP3_21729870_ChIP-Seq_TREG_Human1.38172405
81* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36089497
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35510935
83VDR_23849224_ChIP-Seq_CD4+_Human1.34381363
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34063831
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33638375
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32677733
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32439643
88EZH2_22144423_ChIP-Seq_EOC_Human1.31451405
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31271838
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.30701963
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29984077
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29686002
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.29681409
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29307163
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28932670
96* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28592419
97CREB1_26743006_Chip-Seq_LNCaP_Human1.28075202
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27624205
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.27420983
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25379339
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.25366423
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24982259
103NCOR1_26117541_ChIP-Seq_K562_Human1.24881088
104TP53_22127205_ChIP-Seq_IMR90_Human1.24662246
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24650781
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24262649
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24164724
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22915694
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.21386517
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20994890
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20093478
112BCOR_27268052_Chip-Seq_Bcells_Human1.20084649
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17784131
114FUS_26573619_Chip-Seq_HEK293_Human1.17329861
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17245992
116PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17023068
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16344912
118KDM5A_27292631_Chip-Seq_BREAST_Human1.15406432
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.14660738
120IRF1_19129219_ChIP-ChIP_H3396_Human1.13324596
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13194114
122PHF8_20622854_ChIP-Seq_HELA_Human1.12344306
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12230946
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.10870738
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09964919
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09566749
127BCL6_27268052_Chip-Seq_Bcells_Human1.08980564
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.08860954
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.08507622
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08259320
131DCP1A_22483619_ChIP-Seq_HELA_Human1.07773039
132ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07686804
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07244732
134* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07244577
135PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06862707
136RUNX_20019798_ChIP-Seq_JUKART_Human1.06793946
137MYC_18940864_ChIP-ChIP_HL60_Human1.06541225
138* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06046517
139* SPI1_23127762_ChIP-Seq_K562_Human1.05501132
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04083010
141CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03407653
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02640667
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01508351
144* TP63_22573176_ChIP-Seq_HFKS_Human1.01351048
145* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00485126
146MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00192217
147OCT4_19829295_ChIP-Seq_ESCs_Human0.99105784
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.98079963
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97787504
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96984911
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96893732
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96828183
153E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96500686
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95471645
155GABP_19822575_ChIP-Seq_HepG2_Human0.95203813
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94941642
157POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94871978
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94275132
159* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94272135
160TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93194579
161* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92996878
162NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91629122
163BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91590816
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90425331
165ISL1_27105846_Chip-Seq_CPCs_Mouse0.90337323
166GATA3_27048872_Chip-Seq_THYMUS_Human0.90235864
167CBX2_27304074_Chip-Seq_ESCs_Mouse0.89994929
168TET1_21451524_ChIP-Seq_MESCs_Mouse0.89963492
169WDR5_24793694_ChIP-Seq_LNCAP_Human0.89620945
170ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88151032
171CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88063417
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86954424
173FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86848122
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85807668
175CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84944289
176SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84030293
177RNF2_27304074_Chip-Seq_NSC_Mouse0.82861712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.30047337
2MP0000569_abnormal_digit_pigmentation3.03789939
3MP0009278_abnormal_bone_marrow3.01570697
4MP0003763_abnormal_thymus_physiology3.01409879
5MP0002009_preneoplasia2.85841587
6MP0006292_abnormal_olfactory_placode2.78522297
7MP0003121_genomic_imprinting2.73484035
8MP0010094_abnormal_chromosome_stability2.72621319
9MP0002254_reproductive_system_inflammat2.44128201
10MP0000566_synostosis2.36594942
11MP0003111_abnormal_nucleus_morphology2.36422918
12MP0003077_abnormal_cell_cycle2.36136443
13MP0008007_abnormal_cellular_replicative2.35587253
14MP0003123_paternal_imprinting2.31202825
15MP0010030_abnormal_orbit_morphology2.28673311
16MP0008058_abnormal_DNA_repair2.18417430
17MP0000537_abnormal_urethra_morphology2.15619791
18MP0003787_abnormal_imprinting2.15151215
19MP0008789_abnormal_olfactory_epithelium1.99318280
20MP0003941_abnormal_skin_development1.99113151
21MP0001188_hyperpigmentation1.99083155
22MP0003890_abnormal_embryonic-extraembry1.97800535
23MP0001800_abnormal_humoral_immune1.96837840
24MP0002938_white_spotting1.96575429
25MP0001873_stomach_inflammation1.93502050
26MP0003385_abnormal_body_wall1.93499791
27MP0003937_abnormal_limbs/digits/tail_de1.91040007
28MP0004381_abnormal_hair_follicle1.88926875
29MP0003705_abnormal_hypodermis_morpholog1.87416278
30MP0004957_abnormal_blastocyst_morpholog1.85012525
31MP0002166_altered_tumor_susceptibility1.82152058
32MP0009053_abnormal_anal_canal1.81797545
33MP0003122_maternal_imprinting1.79034347
34MP0000049_abnormal_middle_ear1.78774495
35MP0003119_abnormal_digestive_system1.78061517
36MP0003693_abnormal_embryo_hatching1.75898701
37MP0000685_abnormal_immune_system1.75648365
38MP0002398_abnormal_bone_marrow1.73942938
39MP0001293_anophthalmia1.72294154
40MP0008932_abnormal_embryonic_tissue1.69858445
41MP0005310_abnormal_salivary_gland1.69208895
42MP0008961_abnormal_basal_metabolism1.68971347
43MP0002102_abnormal_ear_morphology1.66342020
44MP0004185_abnormal_adipocyte_glucose1.61856014
45MP0005394_taste/olfaction_phenotype1.60738635
46MP0005499_abnormal_olfactory_system1.60738635
47MP0005670_abnormal_white_adipose1.57218604
48MP0000350_abnormal_cell_proliferation1.55619031
49MP0009379_abnormal_foot_pigmentation1.54197808
50MP0003938_abnormal_ear_development1.53938065
51MP0002751_abnormal_autonomic_nervous1.53145842
52MP0004264_abnormal_extraembryonic_tissu1.52637737
53MP0003183_abnormal_peptide_metabolism1.51886742
54MP0002138_abnormal_hepatobiliary_system1.45763116
55MP0002084_abnormal_developmental_patter1.44253659
56MP0003315_abnormal_perineum_morphology1.44073928
57* MP0002085_abnormal_embryonic_tissue1.42286627
58MP0001286_abnormal_eye_development1.40907308
59MP0003755_abnormal_palate_morphology1.39316721
60MP0003115_abnormal_respiratory_system1.38918551
61MP0002249_abnormal_larynx_morphology1.38139725
62MP0003942_abnormal_urinary_system1.38065788
63MP0008877_abnormal_DNA_methylation1.37770061
64MP0005220_abnormal_exocrine_pancreas1.37344236
65MP0002722_abnormal_immune_system1.37023188
66MP0003935_abnormal_craniofacial_develop1.36043292
67MP0000689_abnormal_spleen_morphology1.35981910
68MP0003567_abnormal_fetal_cardiomyocyte1.35723895
69* MP0001672_abnormal_embryogenesis/_devel1.34547754
70* MP0005380_embryogenesis_phenotype1.34547754
71MP0001730_embryonic_growth_arrest1.34147914
72* MP0003861_abnormal_nervous_system1.32769705
73MP0000778_abnormal_nervous_system1.32545018
74MP0002089_abnormal_postnatal_growth/wei1.31629121
75MP0000716_abnormal_immune_system1.31309283
76MP0004197_abnormal_fetal_growth/weight/1.31209150
77MP0005387_immune_system_phenotype1.30201546
78MP0001790_abnormal_immune_system1.30201546
79MP0005645_abnormal_hypothalamus_physiol1.29983347
80MP0001697_abnormal_embryo_size1.29269291
81MP0002233_abnormal_nose_morphology1.28883386
82MP0001835_abnormal_antigen_presentation1.28840412
83MP0002396_abnormal_hematopoietic_system1.27550113
84MP0000428_abnormal_craniofacial_morphol1.27142008
85MP0001849_ear_inflammation1.26843343
86MP0001348_abnormal_lacrimal_gland1.24177686
87MP0004858_abnormal_nervous_system1.24124623
88MP0002697_abnormal_eye_size1.23877675
89MP0002234_abnormal_pharynx_morphology1.23127459
90MP0002006_tumorigenesis1.22495684
91MP0002116_abnormal_craniofacial_bone1.21934931
92MP0005397_hematopoietic_system_phenotyp1.21915043
93MP0001545_abnormal_hematopoietic_system1.21915043
94MP0009250_abnormal_appendicular_skeleto1.21274093
95MP0002452_abnormal_antigen_presenting1.20834889
96MP0005367_renal/urinary_system_phenotyp1.20630606
97MP0000516_abnormal_urinary_system1.20630606
98* MP0002088_abnormal_embryonic_growth/wei1.19821879
99* MP0003984_embryonic_growth_retardation1.19448977
100MP0002420_abnormal_adaptive_immunity1.19261666
101MP0001819_abnormal_immune_cell1.18500325
102MP0002429_abnormal_blood_cell1.18405467
103MP0002019_abnormal_tumor_incidence1.17950131
104MP0000432_abnormal_head_morphology1.17492308
105MP0005671_abnormal_response_to1.14302195
106MP0002932_abnormal_joint_morphology1.12573314
107MP0002723_abnormal_immune_serum1.12300344
108MP0002092_abnormal_eye_morphology1.11623107
109MP0005174_abnormal_tail_pigmentation1.10411051
110MP0005666_abnormal_adipose_tissue1.10293646
111MP0004808_abnormal_hematopoietic_stem1.09824970
112MP0010307_abnormal_tumor_latency1.09039753
113MP0002282_abnormal_trachea_morphology1.06209265
114MP0000631_abnormal_neuroendocrine_gland1.06116040
115MP0009672_abnormal_birth_weight1.05390408
116MP0002653_abnormal_ependyma_morphology1.03321603
117MP0002111_abnormal_tail_morphology1.01681759
118MP0002086_abnormal_extraembryonic_tissu1.01300682
119MP0002177_abnormal_outer_ear0.99714510
120MP0004133_heterotaxia0.98307205
121MP0001915_intracranial_hemorrhage0.97537102
122MP0009703_decreased_birth_body0.96970078
123MP0003786_premature_aging0.95542733
124MP0004233_abnormal_muscle_weight0.95262111
125MP0002114_abnormal_axial_skeleton0.95171351
126MP0002277_abnormal_respiratory_mucosa0.93762919
127MP0004134_abnormal_chest_morphology0.93636112
128* MP0002080_prenatal_lethality0.92972711
129MP0000015_abnormal_ear_pigmentation0.92404049
130MP0005076_abnormal_cell_differentiation0.92200399
131MP0005621_abnormal_cell_physiology0.92077169
132MP0004947_skin_inflammation0.91335365
133MP0000678_abnormal_parathyroid_gland0.90833980
134MP0002081_perinatal_lethality0.90720415
135MP0005451_abnormal_body_composition0.89204525
136MP0008995_early_reproductive_senescence0.88976405
137MP0000383_abnormal_hair_follicle0.88945214
138MP0000371_diluted_coat_color0.88390737
139MP0002098_abnormal_vibrissa_morphology0.87697799
140MP0002970_abnormal_white_adipose0.86860782
141MP0003091_abnormal_cell_migration0.84600481
142MP0002928_abnormal_bile_duct0.84353836
143MP0002925_abnormal_cardiovascular_devel0.83260529
144MP0000490_abnormal_crypts_of0.82822347
145MP0002109_abnormal_limb_morphology0.82573660
146MP0000470_abnormal_stomach_morphology0.81543926
147MP0003943_abnormal_hepatobiliary_system0.81401932
148MP0005375_adipose_tissue_phenotype0.81392277
149MP0005000_abnormal_immune_tolerance0.80494724
150MP0000313_abnormal_cell_death0.79858382
151MP0000762_abnormal_tongue_morphology0.79310723
152MP0000733_abnormal_muscle_development0.78908935
153MP0005377_hearing/vestibular/ear_phenot0.78372349
154MP0003878_abnormal_ear_physiology0.78372349
155MP0002095_abnormal_skin_pigmentation0.75302010
156MP0000003_abnormal_adipose_tissue0.73847626
157MP0005391_vision/eye_phenotype0.73806211
158MP0000534_abnormal_ureter_morphology0.73351030
159MP0004130_abnormal_muscle_cell0.73125927
160MP0005075_abnormal_melanosome_morpholog0.72904034
161MP0000703_abnormal_thymus_morphology0.72765464
162MP0003045_fibrosis0.72313452

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.68759671
2Agammaglobulinemia (HP:0004432)3.66487495
3Short 4th metacarpal (HP:0010044)3.53120257
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53120257
5Colitis (HP:0002583)3.27971793
6Genetic anticipation (HP:0003743)3.20388471
7Dysmetric saccades (HP:0000641)2.91593788
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84602453
9Ectopic kidney (HP:0000086)2.80106813
10Chromsome breakage (HP:0040012)2.79295616
11IgA deficiency (HP:0002720)2.78713754
12Broad face (HP:0000283)2.78188426
13Aplasia/Hypoplasia of the sternum (HP:0006714)2.74906938
14Abnormality of the fingertips (HP:0001211)2.64689250
15Medulloblastoma (HP:0002885)2.60325477
16Absent eyebrow (HP:0002223)2.58375399
17Morphological abnormality of the middle ear (HP:0008609)2.58145094
18Abnormal number of incisors (HP:0011064)2.58141997
19Midline defect of the nose (HP:0004122)2.56985054
20Abnormal lung lobation (HP:0002101)2.54431513
21Skull defect (HP:0001362)2.53862487
22Volvulus (HP:0002580)2.51268084
23Patellar aplasia (HP:0006443)2.50682685
24Abnormality of the 4th metacarpal (HP:0010012)2.49007484
25Prominent nose (HP:0000448)2.48970071
26Gastrointestinal stroma tumor (HP:0100723)2.47543526
27Cellulitis (HP:0100658)2.42549540
28Absent eyelashes (HP:0000561)2.42329846
29Abnormality of the columella (HP:0009929)2.39040813
30Gastrointestinal inflammation (HP:0004386)2.37840964
31Aplasia/Hypoplasia of the patella (HP:0006498)2.37497411
32Renal duplication (HP:0000075)2.37083538
33Abnormality of the intervertebral disk (HP:0005108)2.36014297
34Acute lymphatic leukemia (HP:0006721)2.33933665
35Anophthalmia (HP:0000528)2.33270220
36Bilateral microphthalmos (HP:0007633)2.28726057
37Clumsiness (HP:0002312)2.28070342
38Neonatal hypoglycemia (HP:0001998)2.27986047
39Deep palmar crease (HP:0006191)2.27931580
40Urethral obstruction (HP:0000796)2.27584138
41Colon cancer (HP:0003003)2.27497647
42Nephroblastoma (Wilms tumor) (HP:0002667)2.26009433
43Reticulocytopenia (HP:0001896)2.20942886
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.17112398
45Heterotopia (HP:0002282)2.16636976
46Panhypogammaglobulinemia (HP:0003139)2.16375617
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16363837
48Deep philtrum (HP:0002002)2.15950855
49Abnormality of DNA repair (HP:0003254)2.14667509
50Intestinal atresia (HP:0011100)2.13907889
51Partial agenesis of the corpus callosum (HP:0001338)2.13442861
52Atresia of the external auditory canal (HP:0000413)2.10227480
53Trigonocephaly (HP:0000243)2.09901038
54Embryonal renal neoplasm (HP:0011794)2.09114949
55Bifid tongue (HP:0010297)2.08908707
56Impulsivity (HP:0100710)2.08867513
57Sandal gap (HP:0001852)2.07930568
58Germ cell neoplasia (HP:0100728)2.07880673
59Meckel diverticulum (HP:0002245)2.07285971
60Facial hemangioma (HP:0000329)2.07130567
61IgM deficiency (HP:0002850)2.07107967
62Ependymoma (HP:0002888)2.07077592
63Inflammation of the large intestine (HP:0002037)2.07061606
64Truncal obesity (HP:0001956)2.06607447
65Lymphopenia (HP:0001888)2.06255211
66Ureteral stenosis (HP:0000071)2.06206608
67Birth length less than 3rd percentile (HP:0003561)2.05408160
68Renal hypoplasia (HP:0000089)2.04799693
69Abnormality of the ileum (HP:0001549)2.03989191
70Abnormality of the labia minora (HP:0012880)2.03715291
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.03674445
72Poikiloderma (HP:0001029)2.02399510
73Increased nuchal translucency (HP:0010880)1.99986752
74Abnormality of the distal phalanx of the thumb (HP:0009617)1.99744182
75Abnormality of cells of the lymphoid lineage (HP:0012140)1.99126675
76Abnormality of the metopic suture (HP:0005556)1.99018465
77Long palpebral fissure (HP:0000637)1.98627549
78Spinal cord lesions (HP:0100561)1.95849939
79Syringomyelia (HP:0003396)1.95849939
80Abnormality of the parietal bone (HP:0002696)1.95154557
81Asymmetry of the thorax (HP:0001555)1.94811302
82Neoplasm of the adrenal cortex (HP:0100641)1.93961556
83Myelodysplasia (HP:0002863)1.93937809
84Ureteral obstruction (HP:0006000)1.93536203
85Chronic hepatic failure (HP:0100626)1.92818288
86Basal cell carcinoma (HP:0002671)1.90038899
87Spina bifida occulta (HP:0003298)1.86688165
88Proximal placement of thumb (HP:0009623)1.86508509
89High pitched voice (HP:0001620)1.86300134
90Long eyelashes (HP:0000527)1.86025423
91Cupped ear (HP:0000378)1.86010323
92Narrow palate (HP:0000189)1.84826314
93Flat cornea (HP:0007720)1.84458244
94Cutaneous finger syndactyly (HP:0010554)1.83438930
95Abnormality of the incisor (HP:0000676)1.83389515
96Recurrent sinusitis (HP:0011108)1.83340904
97Hypoplastic ischia (HP:0003175)1.83302045
98Esophageal atresia (HP:0002032)1.82904104
99Obstructive sleep apnea (HP:0002870)1.82892433
100Deviation of the thumb (HP:0009603)1.82617503
101Sparse lateral eyebrow (HP:0005338)1.82613966
102Verrucae (HP:0200043)1.82485490
103Papilloma (HP:0012740)1.82485490
104Overriding aorta (HP:0002623)1.82465933
105Pointed chin (HP:0000307)1.81859621
106Abnormality of chromosome stability (HP:0003220)1.81450889
107Pseudobulbar signs (HP:0002200)1.81371054
108Emphysema (HP:0002097)1.80607916
109Meningitis (HP:0001287)1.80448957
110Abnormality of the preputium (HP:0100587)1.79281047
111Abnormality of the renal collecting system (HP:0004742)1.78722660
112Supernumerary ribs (HP:0005815)1.78657360
113Small intestinal stenosis (HP:0012848)1.77460633
114Duodenal stenosis (HP:0100867)1.77460633
115Short middle phalanx of the 5th finger (HP:0004220)1.77378003
116Tented upper lip vermilion (HP:0010804)1.77199216
117Broad thumb (HP:0011304)1.76568977
118Duplicated collecting system (HP:0000081)1.75740740
119High anterior hairline (HP:0009890)1.75736777
120Supernumerary bones of the axial skeleton (HP:0009144)1.75735481
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74356235
122Short thumb (HP:0009778)1.74313032
123Anal stenosis (HP:0002025)1.73627972
124Shawl scrotum (HP:0000049)1.73620077
125Megalocornea (HP:0000485)1.72671183
126Cutaneous syndactyly (HP:0012725)1.72563972
127Optic nerve coloboma (HP:0000588)1.72325013
128Abnormality of the nasolacrimal system (HP:0000614)1.71670503
129Myelomeningocele (HP:0002475)1.70768341
130Flat acetabular roof (HP:0003180)1.70512771
131Precocious puberty (HP:0000826)1.70468162
132Absent radius (HP:0003974)1.69965405
133Thick eyebrow (HP:0000574)1.69692286
134Selective tooth agenesis (HP:0001592)1.69524626
135Facial cleft (HP:0002006)1.68995661
136Recurrent viral infections (HP:0004429)1.68877234
137Abnormality of the carotid arteries (HP:0005344)1.68669039
138Aplasia cutis congenita (HP:0001057)1.68634930
139Astrocytoma (HP:0009592)1.68127093
140Abnormality of the astrocytes (HP:0100707)1.68127093
141Heterochromia iridis (HP:0001100)1.67082355
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67041073
143Lymphangioma (HP:0100764)1.66984882
14411 pairs of ribs (HP:0000878)1.66827569
145Abnormality of the lacrimal duct (HP:0011481)1.66693501
146Abnormality of the aortic arch (HP:0012303)1.66209949
147Renovascular hypertension (HP:0100817)1.64399599
148IgG deficiency (HP:0004315)1.64199784
149Vitreoretinal degeneration (HP:0000655)1.63621314
150Short 5th finger (HP:0009237)1.63090541
151Abnormality of the thoracic spine (HP:0100711)1.63086679
152Elfin facies (HP:0004428)1.63049998
153Microtia (HP:0008551)1.62968213
154Abnormality of the duodenum (HP:0002246)1.62823615
155Recurrent bronchitis (HP:0002837)1.62747729
156Prominent metopic ridge (HP:0005487)1.62176794
157Gastrointestinal atresia (HP:0002589)1.61385116
158Absent forearm bone (HP:0003953)1.61263273
159Aplasia involving forearm bones (HP:0009822)1.61263273
160Short chin (HP:0000331)1.60848512
161Skin tags (HP:0010609)1.60413393
162Triphalangeal thumb (HP:0001199)1.60080351
163Lip pit (HP:0100267)1.59790849
164Sparse scalp hair (HP:0002209)1.59356753
165Abnormality of chromosome segregation (HP:0002916)1.58471694
166Broad phalanges of the hand (HP:0009768)1.58450127
167Papillary thyroid carcinoma (HP:0002895)1.58098157
168Hepatoblastoma (HP:0002884)1.57719208
169Impaired smooth pursuit (HP:0007772)1.57438116
170Cutis marmorata (HP:0000965)1.56055567
171Tracheoesophageal fistula (HP:0002575)1.56037214
172Slow-growing hair (HP:0002217)1.55983405
173Dislocated radial head (HP:0003083)1.55468338
174Abnormality of incisor morphology (HP:0011063)1.55017659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.39490601
2AKT34.10963765
3CDC73.82809688
4SRPK13.49515018
5MKNK13.27560889
6SMG13.20188681
7MAP4K12.85750674
8MKNK22.78824644
9CAMK1D2.67615591
10ICK2.61467930
11CDK122.54206837
12BRD42.45477846
13TGFBR12.38044466
14SIK12.32407986
15PASK2.21037118
16DYRK31.98102623
17WEE11.87020925
18FRK1.79830244
19MAP3K101.76663296
20NEK21.69955622
21CDK71.69373781
22ERN11.67723001
23FGFR41.62893117
24TLK11.62786000
25PLK31.62547257
26PRPF4B1.56673661
27TNK21.56393171
28EPHB21.55618933
29MARK21.54809256
30ATR1.54727331
31TESK21.52806899
32MAP3K131.50288970
33MAP3K71.49341826
34TSSK61.45577990
35VRK11.44430531
36BTK1.40675378
37SIK21.39960670
38CHEK21.39331023
39NUAK11.38425447
40MAPK131.37353203
41MAPK111.33500938
42CDK81.33473273
43PLK11.32010949
44ERBB31.31069123
45TTK1.28152723
46YES11.26913169
47BUB11.26577010
48EIF2AK21.24325802
49DYRK21.23663906
50CHEK11.22824747
51AURKB1.21407483
52SGK21.19496305
53CDC42BPA1.19300699
54SIK31.16615174
55PLK41.16363440
56KSR11.16140591
57BMPR1B1.13237684
58ATM1.11597797
59ACVR1B1.10606299
60CLK11.09492740
61CSF1R1.09376791
62MAP2K21.07423192
63FGFR21.06843642
64TAOK21.06018036
65PNCK1.05747219
66PRKD21.05481858
67BCR1.03379192
68EEF2K1.03239002
69MARK11.01424456
70RPS6KB20.99845966
71CDK40.99786756
72MELK0.98091277
73CDK20.95629177
74CHUK0.92877977
75TAF10.91696684
76BLK0.90883516
77CDK90.89479728
78CDK10.86646277
79STK160.86047322
80TYRO30.84252784
81ZAK0.82451077
82STK40.81321786
83ITK0.80137181
84INSRR0.78852662
85LATS10.77603993
86SYK0.77346345
87PRKCI0.77164982
88IRAK40.76623660
89STK30.74901458
90DYRK1A0.74522545
91MTOR0.74062067
92MAP3K140.73674129
93CDK60.72103808
94RPS6KA40.70234255
95PTK60.69000143
96PDGFRA0.68126758
97IKBKB0.67936739
98HIPK20.65328099
99PRKAA10.64604645
100JAK30.63904698
101AURKA0.63736439
102AKT10.62516791
103ERBB20.62043546
104PIM10.61502207
105PKN20.59547944
106DMPK0.59135171
107KIT0.58672711
108BRAF0.56498601
109IKBKE0.56469825
110UHMK10.55942767
111TTN0.54712851
112MAPK140.54025660
113FGFR30.53270480
114AKT20.52739952
115MAPK80.52264809
116RIPK40.51480591
117HCK0.51317476
118PRKAA20.51294978
119RPS6KC10.50957250
120RPS6KL10.50957250
121CAMK40.50490368
122LCK0.49937902
123SGK30.49607594
124CAMK1G0.49598244
125MAP3K80.48988357
126BMX0.48927844
127PRKDC0.48788566
128FGFR10.48730797
129BRSK20.48711409
130CSNK1D0.48515439
131STK240.47643743
132RPS6KA10.47372460
133CCNB10.47184202
134PDK10.46574707
135GSK3B0.46136849
136PAK40.45674171
137TAOK30.45615862
138RPS6KB10.45325267
139NEK60.44672477
140GRK60.43097623
141PLK20.42549687
142TBK10.42215707
143MARK30.41948892
144STK100.41724962
145MAPK70.41434831
146PDGFRB0.41335841
147LYN0.41183065
148MATK0.40865609
149PRKCH0.39901315
150SGK2230.39252816
151SGK4940.39252816
152STK110.39245023
153RPS6KA20.38649581
154TEC0.38540115
155FES0.37623010
156MAPK30.37467812
157RPS6KA60.36793627
158CAMKK10.36788598
159MAPK10.35594469
160CSNK2A20.35474615
161CSNK1A1L0.35354804

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.49099195
2Mismatch repair_Homo sapiens_hsa034303.27714607
3Spliceosome_Homo sapiens_hsa030403.26785111
4Cell cycle_Homo sapiens_hsa041102.67419595
5Homologous recombination_Homo sapiens_hsa034402.64192032
6Base excision repair_Homo sapiens_hsa034102.59053297
7mRNA surveillance pathway_Homo sapiens_hsa030152.49529440
8RNA transport_Homo sapiens_hsa030132.37589356
9Fanconi anemia pathway_Homo sapiens_hsa034602.31510741
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21790123
11Nucleotide excision repair_Homo sapiens_hsa034202.16574221
12Basal cell carcinoma_Homo sapiens_hsa052172.08927022
13One carbon pool by folate_Homo sapiens_hsa006702.08331933
14RNA degradation_Homo sapiens_hsa030181.98345263
15Non-homologous end-joining_Homo sapiens_hsa034501.96745795
16RNA polymerase_Homo sapiens_hsa030201.90431151
17Ribosome_Homo sapiens_hsa030101.86838844
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77544603
19Basal transcription factors_Homo sapiens_hsa030221.74884828
20Notch signaling pathway_Homo sapiens_hsa043301.61160481
21MicroRNAs in cancer_Homo sapiens_hsa052061.57896013
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52117482
23Hedgehog signaling pathway_Homo sapiens_hsa043401.48669187
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41137173
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36710615
26Hippo signaling pathway_Homo sapiens_hsa043901.35503798
27Colorectal cancer_Homo sapiens_hsa052101.32288657
28Pyrimidine metabolism_Homo sapiens_hsa002401.25809781
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24690658
30Graft-versus-host disease_Homo sapiens_hsa053321.24271105
31Inositol phosphate metabolism_Homo sapiens_hsa005621.23834223
32HTLV-I infection_Homo sapiens_hsa051661.23789754
33Adherens junction_Homo sapiens_hsa045201.22335162
34Allograft rejection_Homo sapiens_hsa053301.21929117
35p53 signaling pathway_Homo sapiens_hsa041151.21152817
36Wnt signaling pathway_Homo sapiens_hsa043101.15888088
37Prostate cancer_Homo sapiens_hsa052151.15594258
38Axon guidance_Homo sapiens_hsa043601.14437203
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13369369
40* Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13220531
41VEGF signaling pathway_Homo sapiens_hsa043701.11962326
42Herpes simplex infection_Homo sapiens_hsa051681.11225332
43Epstein-Barr virus infection_Homo sapiens_hsa051691.10570485
44ABC transporters_Homo sapiens_hsa020101.07375304
45Systemic lupus erythematosus_Homo sapiens_hsa053221.07147169
46Viral carcinogenesis_Homo sapiens_hsa052031.06346146
47Small cell lung cancer_Homo sapiens_hsa052221.04628602
48* Lysine degradation_Homo sapiens_hsa003101.04371914
49Chronic myeloid leukemia_Homo sapiens_hsa052201.03841796
50TGF-beta signaling pathway_Homo sapiens_hsa043501.02601704
51Viral myocarditis_Homo sapiens_hsa054160.98640838
52Asthma_Homo sapiens_hsa053100.96941969
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96215312
54Endometrial cancer_Homo sapiens_hsa052130.96112033
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95665111
56Thyroid cancer_Homo sapiens_hsa052160.92385651
57Prolactin signaling pathway_Homo sapiens_hsa049170.92242282
58Pathways in cancer_Homo sapiens_hsa052000.89967115
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89773246
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89619898
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87197923
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86000083
63AMPK signaling pathway_Homo sapiens_hsa041520.82222723
64Platelet activation_Homo sapiens_hsa046110.81386617
65Toxoplasmosis_Homo sapiens_hsa051450.81139301
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80696858
67Non-small cell lung cancer_Homo sapiens_hsa052230.80586175
68Insulin resistance_Homo sapiens_hsa049310.80543552
69Oocyte meiosis_Homo sapiens_hsa041140.79922359
70Hepatitis C_Homo sapiens_hsa051600.78763463
71mTOR signaling pathway_Homo sapiens_hsa041500.77949520
72Acute myeloid leukemia_Homo sapiens_hsa052210.77566157
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.74739276
74Dorso-ventral axis formation_Homo sapiens_hsa043200.73894166
75Pancreatic cancer_Homo sapiens_hsa052120.73322042
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.73231853
77Fatty acid biosynthesis_Homo sapiens_hsa000610.72584406
78Insulin signaling pathway_Homo sapiens_hsa049100.71977798
79Proteoglycans in cancer_Homo sapiens_hsa052050.71906328
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.71067362
81Alcoholism_Homo sapiens_hsa050340.70497633
82Leishmaniasis_Homo sapiens_hsa051400.69742694
83Hepatitis B_Homo sapiens_hsa051610.69571163
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68215148
85Type II diabetes mellitus_Homo sapiens_hsa049300.67333993
86Melanoma_Homo sapiens_hsa052180.66008148
87Type I diabetes mellitus_Homo sapiens_hsa049400.64296397
88Purine metabolism_Homo sapiens_hsa002300.63618258
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63507705
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61440040
91Glioma_Homo sapiens_hsa052140.61112432
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60985058
93FoxO signaling pathway_Homo sapiens_hsa040680.60827877
94Measles_Homo sapiens_hsa051620.60565891
95Melanogenesis_Homo sapiens_hsa049160.60460208
96Proteasome_Homo sapiens_hsa030500.59998784
97Estrogen signaling pathway_Homo sapiens_hsa049150.58949385
98Primary immunodeficiency_Homo sapiens_hsa053400.58603213
99T cell receptor signaling pathway_Homo sapiens_hsa046600.58259656
100Focal adhesion_Homo sapiens_hsa045100.57153514
101Ovarian steroidogenesis_Homo sapiens_hsa049130.56579853
102Renal cell carcinoma_Homo sapiens_hsa052110.55785334
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55171785
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.54890644
105Other glycan degradation_Homo sapiens_hsa005110.54716642
106ErbB signaling pathway_Homo sapiens_hsa040120.53507631
107Influenza A_Homo sapiens_hsa051640.52647036
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52011947
109Bladder cancer_Homo sapiens_hsa052190.50044029
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49850964
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49047239
112Apoptosis_Homo sapiens_hsa042100.46900682
113Tight junction_Homo sapiens_hsa045300.46738959
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42935529
115B cell receptor signaling pathway_Homo sapiens_hsa046620.41977490
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41834605
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.41425964
118ECM-receptor interaction_Homo sapiens_hsa045120.40654521
119Selenocompound metabolism_Homo sapiens_hsa004500.40223478
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40157975
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.39304491
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39241201
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39236315
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38319248
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37959905
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.37413110
127MAPK signaling pathway_Homo sapiens_hsa040100.35865889
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.34628651
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33246761
130Choline metabolism in cancer_Homo sapiens_hsa052310.33097934
131Antigen processing and presentation_Homo sapiens_hsa046120.32649052
132Rap1 signaling pathway_Homo sapiens_hsa040150.32029050
133Autoimmune thyroid disease_Homo sapiens_hsa053200.30213391
134TNF signaling pathway_Homo sapiens_hsa046680.29099025

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