EHMT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.11929732
2positive regulation of histone deacetylation (GO:0031065)4.08356263
3convergent extension (GO:0060026)4.03123547
4negative regulation of cell size (GO:0045792)3.98974651
5cell migration in hindbrain (GO:0021535)3.94882406
6pre-miRNA processing (GO:0031054)3.87724574
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.86416141
8peptidyl-arginine omega-N-methylation (GO:0035247)3.84801674
9histone arginine methylation (GO:0034969)3.60666100
10paraxial mesoderm development (GO:0048339)3.52615614
11positive regulation of synapse maturation (GO:0090129)3.41731398
12regulation of hippo signaling (GO:0035330)3.39354208
13regulation of translational fidelity (GO:0006450)3.38651226
14negative regulation of mRNA processing (GO:0050686)3.37000341
15peptidyl-arginine N-methylation (GO:0035246)3.35876304
16peptidyl-arginine methylation (GO:0018216)3.35876304
17L-serine metabolic process (GO:0006563)3.26998277
18maternal placenta development (GO:0001893)3.23259232
19establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.23159824
20mitochondrion transport along microtubule (GO:0047497)3.23159824
21regulation of NFAT protein import into nucleus (GO:0051532)3.22686396
22NLS-bearing protein import into nucleus (GO:0006607)3.21352693
23mitotic chromosome condensation (GO:0007076)3.20674564
24negative regulation of mRNA metabolic process (GO:1903312)3.19919548
25establishment of apical/basal cell polarity (GO:0035089)3.19756784
26establishment of mitochondrion localization (GO:0051654)3.17882940
27adherens junction assembly (GO:0034333)3.14534530
28glial cell proliferation (GO:0014009)3.13897922
29layer formation in cerebral cortex (GO:0021819)3.11995800
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11884055
31regulation of translational termination (GO:0006449)3.10978755
32regulation of ARF GTPase activity (GO:0032312)3.06298313
33DNA strand elongation involved in DNA replication (GO:0006271)3.05775042
34DNA replication initiation (GO:0006270)3.03450321
35stress fiber assembly (GO:0043149)3.02469087
36activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.00893832
37intracellular estrogen receptor signaling pathway (GO:0030520)3.00880140
38apoptotic cell clearance (GO:0043277)3.00660268
39neural tube development (GO:0021915)2.98839819
40mRNA stabilization (GO:0048255)2.98511148
41RNA stabilization (GO:0043489)2.98511148
42cytoplasmic mRNA processing body assembly (GO:0033962)2.97825991
43nuclear pore complex assembly (GO:0051292)2.94901814
44DNA strand elongation (GO:0022616)2.93683438
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.93422036
46glucocorticoid receptor signaling pathway (GO:0042921)2.93300036
47DNA topological change (GO:0006265)2.93261717
48epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92899118
49gene silencing (GO:0016458)2.92431877
50positive regulation of nuclease activity (GO:0032075)2.91929587
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.91466858
52negative regulation of histone methylation (GO:0031061)2.90612155
53RNA localization (GO:0006403)2.89910593
54protein complex localization (GO:0031503)2.89497466
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89385343
56DNA duplex unwinding (GO:0032508)2.88508272
57mitotic G1 DNA damage checkpoint (GO:0031571)2.87573297
58mannose metabolic process (GO:0006013)2.85513861
59semaphorin-plexin signaling pathway (GO:0071526)2.81606497
60chromatin silencing (GO:0006342)2.81085569
61polarized epithelial cell differentiation (GO:0030859)2.80630821
62gene silencing by RNA (GO:0031047)2.79870679
63mitotic sister chromatid segregation (GO:0000070)2.78196126
64establishment of integrated proviral latency (GO:0075713)2.77619507
65cell-cell junction maintenance (GO:0045217)2.77317936
66positive regulation of gene expression, epigenetic (GO:0045815)2.75714826
67chromosome condensation (GO:0030261)2.75351255
68chromatin assembly (GO:0031497)2.74015365
69negative regulation of RNA splicing (GO:0033119)2.73036621
70embryonic foregut morphogenesis (GO:0048617)2.72395819
71nucleosome disassembly (GO:0006337)2.72355943
72protein-DNA complex disassembly (GO:0032986)2.72355943
73regulation of establishment of planar polarity (GO:0090175)2.71960620
74protein localization to endosome (GO:0036010)2.71118018
75negative regulation of fatty acid transport (GO:2000192)2.70731181
76Golgi transport vesicle coating (GO:0048200)2.70618448
77COPI coating of Golgi vesicle (GO:0048205)2.70618448
78focal adhesion assembly (GO:0048041)2.70080038
79cell-substrate adherens junction assembly (GO:0007045)2.70080038
80regulation of fatty acid beta-oxidation (GO:0031998)2.69947772
81DNA geometric change (GO:0032392)2.69812808
82regulation of early endosome to late endosome transport (GO:2000641)2.68057741
83nuclear pore organization (GO:0006999)2.67580782
84receptor catabolic process (GO:0032801)2.67225105
85regulation of chromatin binding (GO:0035561)2.67083899
86sister chromatid segregation (GO:0000819)2.66749657
87positive regulation of RNA splicing (GO:0033120)2.66397842
88sodium ion export (GO:0071436)2.66171486
89protein heterotrimerization (GO:0070208)2.65262827
90positive regulation of protein deacetylation (GO:0090312)2.64611414
91rRNA transcription (GO:0009303)2.63147723
92establishment of monopolar cell polarity (GO:0061162)2.62648388
93establishment or maintenance of monopolar cell polarity (GO:0061339)2.62648388
94regulation of nuclease activity (GO:0032069)2.61849423
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61467616
96ATP-dependent chromatin remodeling (GO:0043044)2.60788301
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59746930
98activation of Rac GTPase activity (GO:0032863)2.59697483
99cell-substrate junction assembly (GO:0007044)2.58163329
100apoptotic process involved in morphogenesis (GO:0060561)2.56301375
101spliceosomal tri-snRNP complex assembly (GO:0000244)2.53124525
102signal complex assembly (GO:0007172)2.52185472
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51749146
104histone H3-K9 demethylation (GO:0033169)2.51666616
105regulation of synapse maturation (GO:0090128)2.50652817
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.49546847
107locomotory exploration behavior (GO:0035641)2.49448296
108notochord development (GO:0030903)2.49231230
109DNA conformation change (GO:0071103)2.49039471
110negative regulation of gene expression, epigenetic (GO:0045814)2.48175665
111activation of JUN kinase activity (GO:0007257)2.47672451
112sexual reproduction (GO:0019953)2.47381130
113histone H4 deacetylation (GO:0070933)2.46818281
114proline biosynthetic process (GO:0006561)2.46403083
115regulation of histone H3-K9 methylation (GO:0051570)2.45478173
116regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45422667
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44979331
118cellular response to epidermal growth factor stimulus (GO:0071364)2.44649730
119telomere maintenance via semi-conservative replication (GO:0032201)2.44018295
120generation of neurons (GO:0048699)2.43185038
121macroautophagy (GO:0016236)2.42746114
122cortical actin cytoskeleton organization (GO:0030866)2.42253276
123regulation of short-term neuronal synaptic plasticity (GO:0048172)2.41269008
124endoplasmic reticulum unfolded protein response (GO:0030968)2.40704578
125negative regulation of organelle assembly (GO:1902116)2.40567722
126negative regulation of microtubule polymerization (GO:0031115)2.39451045
127stress granule assembly (GO:0034063)2.38362805
128mitotic G1/S transition checkpoint (GO:0044819)2.38220997
129establishment of nucleus localization (GO:0040023)2.38169192
130regulation of ARF protein signal transduction (GO:0032012)2.37955688
131negative regulation of telomerase activity (GO:0051974)2.37627749
132regulation of posttranscriptional gene silencing (GO:0060147)2.36192004
133regulation of gene silencing by miRNA (GO:0060964)2.36192004
134regulation of gene silencing by RNA (GO:0060966)2.36192004
135gastrulation with mouth forming second (GO:0001702)2.35313131
136dosage compensation (GO:0007549)2.35167717
137synaptic vesicle endocytosis (GO:0048488)2.35102477
138mRNA polyadenylation (GO:0006378)2.34343238
139negative regulation of erythrocyte differentiation (GO:0045647)2.33918437
140ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.33745527
141hippo signaling (GO:0035329)2.33205578
142* peptidyl-lysine dimethylation (GO:0018027)2.31476314
143histone H4-K5 acetylation (GO:0043981)2.30887627
144histone H4-K8 acetylation (GO:0043982)2.30887627
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30767527
146morphogenesis of an endothelium (GO:0003159)2.30453058
147endothelial tube morphogenesis (GO:0061154)2.30453058
148response to epidermal growth factor (GO:0070849)2.30109306
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.29132821
150establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.29016718
151corticosteroid receptor signaling pathway (GO:0031958)2.28891400
152anatomical structure regression (GO:0060033)2.27711909
153regulation of RNA export from nucleus (GO:0046831)2.27604349
154negative regulation of cell fate specification (GO:0009996)2.27369824
155positive regulation of dendrite morphogenesis (GO:0050775)2.27295250
156cellular response to unfolded protein (GO:0034620)2.27011220
157peptidyl-threonine modification (GO:0018210)2.26765023
158G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.26743685
159postsynaptic membrane organization (GO:0001941)2.26645429
160chromatin remodeling (GO:0006338)2.26183583
161DNA unwinding involved in DNA replication (GO:0006268)2.26166017
162establishment or maintenance of apical/basal cell polarity (GO:0035088)2.26099961
163establishment or maintenance of bipolar cell polarity (GO:0061245)2.26099961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45433416
2MYC_22102868_ChIP-Seq_BL_Human3.42683836
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.12852285
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.09682837
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.97088562
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.88952198
7KDM2B_26808549_Chip-Seq_DND41_Human2.72809442
8TCF7_22412390_ChIP-Seq_EML_Mouse2.64568983
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59415910
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55407413
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42532632
12* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36715097
13LXR_22292898_ChIP-Seq_THP-1_Human2.36292495
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35489553
15VDR_21846776_ChIP-Seq_THP-1_Human2.33998519
16E2F7_22180533_ChIP-Seq_HELA_Human2.31112707
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16173177
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.14466959
19* MYC_18555785_ChIP-Seq_MESCs_Mouse2.14008708
20* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.13477378
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07609330
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.05971444
23* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05675168
24KDM2B_26808549_Chip-Seq_K562_Human2.03425357
25ZNF263_19887448_ChIP-Seq_K562_Human1.93752950
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.90027428
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88282075
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.86885645
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82644966
30RACK7_27058665_Chip-Seq_MCF-7_Human1.77963164
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76829498
32* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75820291
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.73630581
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73249243
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71346166
36XRN2_22483619_ChIP-Seq_HELA_Human1.67596224
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63884148
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63811640
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61474614
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60546726
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60328963
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.59869947
43CREB1_26743006_Chip-Seq_LNCaP_Human1.57207033
44UTX_26944678_Chip-Seq_JUKART_Human1.55658495
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51627226
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51545584
47CLOCK_20551151_ChIP-Seq_293T_Human1.49588376
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49477108
49P68_20966046_ChIP-Seq_HELA_Human1.47387036
50MAF_26560356_Chip-Seq_TH1_Human1.45866236
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43345312
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43200423
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43114889
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42115010
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41787227
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40219508
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40087903
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39871275
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38507629
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38348711
61NCOR1_26117541_ChIP-Seq_K562_Human1.37556189
62TP53_22127205_ChIP-Seq_IMR90_Human1.35098117
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.34156991
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33989442
65ATF3_27146783_Chip-Seq_COLON_Human1.33517873
66CTCF_27219007_Chip-Seq_Bcells_Human1.32862066
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.32323703
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30402065
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29700528
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29549501
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.28591213
72SMC4_20622854_ChIP-Seq_HELA_Human1.27675454
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.27260502
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25857165
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25213251
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24958966
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24289722
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22608974
79* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20686175
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20608653
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20269519
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20137698
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19943848
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19901737
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19462656
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17965202
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17204500
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16842350
89VDR_24763502_ChIP-Seq_THP-1_Human1.16442670
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.16246475
91* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16009051
92POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15684769
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14331850
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13509232
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10345021
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09976815
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09586605
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09389125
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09120436
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08479034
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08370791
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08264118
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.07866488
104KDM5A_27292631_Chip-Seq_BREAST_Human1.07631842
105* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06905023
106* E2F1_21310950_ChIP-Seq_MCF-7_Human1.06862326
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06267288
108* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06260269
109SPI1_23127762_ChIP-Seq_K562_Human1.05855051
110PHF8_20622854_ChIP-Seq_HELA_Human1.05750320
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.05746267
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05071235
113BCOR_27268052_Chip-Seq_Bcells_Human1.05050617
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04940235
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04723367
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04636717
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03214500
118DROSHA_22980978_ChIP-Seq_HELA_Human1.03170458
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02760914
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02739710
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02549170
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.02458713
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.01407780
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00858384
125MAF_26560356_Chip-Seq_TH2_Human1.00327692
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00294048
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.99522914
128TP63_22573176_ChIP-Seq_HFKS_Human0.97518855
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96776349
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96720332
131CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96012725
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.95739008
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94958485
134* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93585134
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93405837
136CIITA_25753668_ChIP-Seq_RAJI_Human0.92703501
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.90819148
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89605884
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89292887
140BCL6_27268052_Chip-Seq_Bcells_Human0.89237761
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88928948
142HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87439921
143CHD1_26751641_Chip-Seq_LNCaP_Human0.87014784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.10290648
2MP0005076_abnormal_cell_differentiation3.41660482
3MP0010234_abnormal_vibrissa_follicle3.33908491
4MP0003283_abnormal_digestive_organ2.91500223
5MP0010352_gastrointestinal_tract_polyps2.84888123
6MP0003300_gastrointestinal_ulcer2.73696550
7MP0000569_abnormal_digit_pigmentation2.63801780
8MP0000566_synostosis2.58884582
9MP0009278_abnormal_bone_marrow2.54360864
10MP0008961_abnormal_basal_metabolism2.51119830
11MP0005623_abnormal_meninges_morphology2.40855952
12MP0001849_ear_inflammation2.23235734
13MP0008438_abnormal_cutaneous_collagen2.22419516
14MP0002249_abnormal_larynx_morphology2.18280913
15MP0003693_abnormal_embryo_hatching2.16814657
16MP0004858_abnormal_nervous_system2.12594686
17MP0003303_peritoneal_inflammation2.10822992
18MP0000537_abnormal_urethra_morphology2.10653063
19MP0010094_abnormal_chromosome_stability2.06982959
20MP0010307_abnormal_tumor_latency2.04788727
21MP0004859_abnormal_synaptic_plasticity1.99560380
22MP0006292_abnormal_olfactory_placode1.90376363
23MP0003566_abnormal_cell_adhesion1.82152858
24MP0000778_abnormal_nervous_system1.81039353
25MP0000733_abnormal_muscle_development1.75141029
26MP0002877_abnormal_melanocyte_morpholog1.67828293
27MP0005410_abnormal_fertilization1.67756945
28MP0004185_abnormal_adipocyte_glucose1.65991698
29MP0008932_abnormal_embryonic_tissue1.64033731
30MP0004957_abnormal_blastocyst_morpholog1.63485077
31MP0004197_abnormal_fetal_growth/weight/1.62322045
32MP0003122_maternal_imprinting1.60373405
33MP0003115_abnormal_respiratory_system1.60209596
34MP0002653_abnormal_ependyma_morphology1.57105569
35MP0003123_paternal_imprinting1.55118520
36MP0009780_abnormal_chondrocyte_physiolo1.54839289
37MP0004270_analgesia1.54404684
38MP0002909_abnormal_adrenal_gland1.54399407
39MP0000049_abnormal_middle_ear1.52121950
40MP0004233_abnormal_muscle_weight1.48752068
41MP0005423_abnormal_somatic_nervous1.46565758
42MP0003136_yellow_coat_color1.43648203
43MP0003938_abnormal_ear_development1.42230822
44MP0003635_abnormal_synaptic_transmissio1.41111854
45MP0003172_abnormal_lysosome_physiology1.40229471
46MP0003045_fibrosis1.39848223
47MP0003091_abnormal_cell_migration1.38350345
48MP0001293_anophthalmia1.38131870
49MP0003119_abnormal_digestive_system1.35662952
50MP0002084_abnormal_developmental_patter1.34840803
51MP0001299_abnormal_eye_distance/1.33641562
52* MP0001730_embryonic_growth_arrest1.33451647
53MP0004808_abnormal_hematopoietic_stem1.30848961
54MP0000003_abnormal_adipose_tissue1.29895056
55MP0005375_adipose_tissue_phenotype1.28783125
56MP0002152_abnormal_brain_morphology1.27452673
57MP0005499_abnormal_olfactory_system1.27254568
58MP0005394_taste/olfaction_phenotype1.27254568
59MP0002116_abnormal_craniofacial_bone1.26347482
60MP0002822_catalepsy1.24327381
61MP0005666_abnormal_adipose_tissue1.24299245
62MP0004133_heterotaxia1.24209618
63MP0000534_abnormal_ureter_morphology1.23944618
64MP0000955_abnormal_spinal_cord1.22895302
65MP0003937_abnormal_limbs/digits/tail_de1.22287500
66MP0001348_abnormal_lacrimal_gland1.19755755
67MP0000428_abnormal_craniofacial_morphol1.18221446
68MP0003111_abnormal_nucleus_morphology1.18085792
69MP0002089_abnormal_postnatal_growth/wei1.17843042
70MP0001958_emphysema1.17549714
71MP0008877_abnormal_DNA_methylation1.17537171
72MP0009672_abnormal_birth_weight1.17156776
73MP0005023_abnormal_wound_healing1.16653962
74* MP0002086_abnormal_extraembryonic_tissu1.15529963
75MP0005670_abnormal_white_adipose1.14366934
76MP0004272_abnormal_basement_membrane1.13969536
77* MP0002063_abnormal_learning/memory/cond1.13382774
78MP0000678_abnormal_parathyroid_gland1.11566278
79MP0003880_abnormal_central_pattern1.09395086
80MP0005275_abnormal_skin_tensile1.09206585
81MP0009053_abnormal_anal_canal1.07345934
82MP0001672_abnormal_embryogenesis/_devel1.05424123
83MP0005380_embryogenesis_phenotype1.05424123
84MP0003878_abnormal_ear_physiology1.04469989
85MP0005377_hearing/vestibular/ear_phenot1.04469989
86* MP0002085_abnormal_embryonic_tissue1.03228122
87MP0002184_abnormal_innervation1.03056555
88* MP0004811_abnormal_neuron_physiology1.02293436
89MP0001915_intracranial_hemorrhage1.02291084
90MP0001286_abnormal_eye_development1.01998916
91MP0003984_embryonic_growth_retardation1.01687979
92MP0002088_abnormal_embryonic_growth/wei1.01621221
93MP0002081_perinatal_lethality1.01455619
94MP0000432_abnormal_head_morphology0.99928206
95MP0009703_decreased_birth_body0.99760859
96MP0000350_abnormal_cell_proliferation0.99687872
97MP0003890_abnormal_embryonic-extraembry0.99684811
98MP0002233_abnormal_nose_morphology0.98902007
99MP0002234_abnormal_pharynx_morphology0.97324836
100MP0002896_abnormal_bone_mineralization0.96920871
101* MP0002080_prenatal_lethality0.96034848
102MP0008770_decreased_survivor_rate0.95711921
103MP0003315_abnormal_perineum_morphology0.95351231
104MP0005397_hematopoietic_system_phenotyp0.94497775
105MP0001545_abnormal_hematopoietic_system0.94497775
106MP0001346_abnormal_lacrimal_gland0.94344064
107MP0006054_spinal_hemorrhage0.94126557
108MP0002882_abnormal_neuron_morphology0.93950958
109MP0004130_abnormal_muscle_cell0.93823968
110MP0002925_abnormal_cardiovascular_devel0.93603541
111MP0005167_abnormal_blood-brain_barrier0.93074321
112MP0002734_abnormal_mechanical_nocicepti0.90942130
113MP0002114_abnormal_axial_skeleton0.88422031
114MP0002254_reproductive_system_inflammat0.88284585
115MP0003755_abnormal_palate_morphology0.87535771
116* MP0001697_abnormal_embryo_size0.86967128
117MP0000631_abnormal_neuroendocrine_gland0.86002401
118MP0002697_abnormal_eye_size0.84076843
119MP0002092_abnormal_eye_morphology0.82954554
120MP0010030_abnormal_orbit_morphology0.82798900
121MP0002735_abnormal_chemical_nociception0.81985858
122MP0001502_abnormal_circadian_rhythm0.80945323
123MP0003698_abnormal_male_reproductive0.80663748
124MP0002557_abnormal_social/conspecific_i0.80264503
125MP0003942_abnormal_urinary_system0.80216513
126MP0005171_absent_coat_pigmentation0.77720976
127MP0002064_seizures0.77662891
128MP0003935_abnormal_craniofacial_develop0.77629289
129MP0003567_abnormal_fetal_cardiomyocyte0.77410056
130MP0008058_abnormal_DNA_repair0.77151757
131MP0002938_white_spotting0.76941004
132MP0001929_abnormal_gametogenesis0.76724358
133MP0002751_abnormal_autonomic_nervous0.76706434
134MP0004264_abnormal_extraembryonic_tissu0.76111355
135MP0010630_abnormal_cardiac_muscle0.75931362
136MP0002932_abnormal_joint_morphology0.75786794
137MP0001340_abnormal_eyelid_morphology0.75705612
138MP0000013_abnormal_adipose_tissue0.75305996
139MP0005187_abnormal_penis_morphology0.74622025
140MP0000371_diluted_coat_color0.73816690
141MP0004947_skin_inflammation0.73213624
142MP0004885_abnormal_endolymph0.72048878
143MP0003279_aneurysm0.71292233
144MP0005257_abnormal_intraocular_pressure0.71008427
145MP0009840_abnormal_foam_cell0.68095655
146MP0000266_abnormal_heart_morphology0.67687468
147MP0004087_abnormal_muscle_fiber0.67437647
148* MP0003861_abnormal_nervous_system0.66896216
149MP0002928_abnormal_bile_duct0.66438751
150MP0001784_abnormal_fluid_regulation0.62441423
151MP0004510_myositis0.61855036
152MP0000751_myopathy0.61811816
153MP0002111_abnormal_tail_morphology0.61708757
154MP0003385_abnormal_body_wall0.60990369
155MP0001145_abnormal_male_reproductive0.60957529
156MP0003077_abnormal_cell_cycle0.59707233

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.31953947
2Cerebral aneurysm (HP:0004944)4.01264103
3Abnormality of the lower motor neuron (HP:0002366)3.35305564
4Renovascular hypertension (HP:0100817)3.25134488
5Distal upper limb amyotrophy (HP:0007149)3.24812325
6Upper limb amyotrophy (HP:0009129)3.24812325
7Elfin facies (HP:0004428)3.23074485
8Hand muscle atrophy (HP:0009130)3.20234531
9High anterior hairline (HP:0009890)3.13533354
10Insomnia (HP:0100785)3.08154804
11Shallow orbits (HP:0000586)3.06343866
12Renal duplication (HP:0000075)3.03829977
13Bronchomalacia (HP:0002780)2.90537455
14Protrusio acetabuli (HP:0003179)2.88120948
15Bladder diverticulum (HP:0000015)2.77622284
16Overriding aorta (HP:0002623)2.71420132
17Bowel diverticulosis (HP:0005222)2.71360663
18Trigonocephaly (HP:0000243)2.69033086
19Ankle contracture (HP:0006466)2.68334775
20Pointed chin (HP:0000307)2.62165281
21Broad distal phalanx of finger (HP:0009836)2.60019783
22Short 4th metacarpal (HP:0010044)2.54640217
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54640217
24Macroorchidism (HP:0000053)2.49939533
25Obstructive sleep apnea (HP:0002870)2.46071068
26Astrocytoma (HP:0009592)2.38902217
27Abnormality of the astrocytes (HP:0100707)2.38902217
28Abnormality of the aortic arch (HP:0012303)2.36315310
29Flat cornea (HP:0007720)2.35674636
30Genu recurvatum (HP:0002816)2.34329881
31Subacute progressive viral hepatitis (HP:0006572)2.34219945
32Ependymoma (HP:0002888)2.32481681
33Enlarged penis (HP:0000040)2.31643496
34Mitral valve prolapse (HP:0001634)2.31365822
35Lymphangioma (HP:0100764)2.29953316
36Choanal stenosis (HP:0000452)2.28437460
37Neoplasm of the heart (HP:0100544)2.28070325
38Morphological abnormality of the inner ear (HP:0011390)2.25033403
39Ulnar bowing (HP:0003031)2.24328644
40Aneurysm (HP:0002617)2.23201715
41Spina bifida occulta (HP:0003298)2.19085475
42Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18931604
43Absent epiphyses (HP:0010577)2.18931604
44Generalized hypotonia (HP:0001290)2.17626751
45Abnormality of the 4th metacarpal (HP:0010012)2.15716053
46Heterotopia (HP:0002282)2.15654961
47Abnormality of cochlea (HP:0000375)2.15203287
48Hallux valgus (HP:0001822)2.13295640
49Ankyloglossia (HP:0010296)2.12380879
50Increased nuchal translucency (HP:0010880)2.11819645
51Deviation of the hallux (HP:0010051)2.11418321
52Dilatation of the ascending aorta (HP:0005111)2.10816710
53Vitreoretinal degeneration (HP:0000655)2.10481632
54Deep palmar crease (HP:0006191)2.10243446
55Turricephaly (HP:0000262)2.08257970
56Disproportionate tall stature (HP:0001519)2.07035588
57Thin bony cortex (HP:0002753)2.04315723
58Broad phalanges of the hand (HP:0009768)2.04032068
59Hepatoblastoma (HP:0002884)2.01493696
60Abnormality of oral frenula (HP:0000190)1.98724252
61Long palpebral fissure (HP:0000637)1.98274306
62Nasal polyposis (HP:0100582)1.96687927
63Male infertility (HP:0003251)1.96032457
64Rectal prolapse (HP:0002035)1.95683345
65Broad finger (HP:0001500)1.95235207
66Broad metatarsal (HP:0001783)1.93853058
67Precocious puberty (HP:0000826)1.92920237
68Achilles tendon contracture (HP:0001771)1.91685525
69Fibroma (HP:0010614)1.91281917
70Cortical dysplasia (HP:0002539)1.90785363
71Patellar aplasia (HP:0006443)1.89827697
72Long toe (HP:0010511)1.89318016
73Pseudobulbar signs (HP:0002200)1.86834211
74Resting tremor (HP:0002322)1.86390605
75Premature rupture of membranes (HP:0001788)1.85900779
76Patellar dislocation (HP:0002999)1.84615802
77Fibrous tissue neoplasm (HP:0012316)1.84520414
78Myokymia (HP:0002411)1.84453555
79Tracheomalacia (HP:0002779)1.84272654
80Aortic aneurysm (HP:0004942)1.84109043
81Peripheral hypomyelination (HP:0007182)1.84083846
82Selective tooth agenesis (HP:0001592)1.83230849
83Coronal craniosynostosis (HP:0004440)1.82370023
84Abnormality of the fingertips (HP:0001211)1.81630678
85Buphthalmos (HP:0000557)1.80507890
86Back pain (HP:0003418)1.80416638
87Broad palm (HP:0001169)1.79437493
88Broad face (HP:0000283)1.78794370
89Megalocornea (HP:0000485)1.77290979
90High pitched voice (HP:0001620)1.76050313
91Abnormality of the Achilles tendon (HP:0005109)1.75917597
92Obsessive-compulsive behavior (HP:0000722)1.75881624
93Germ cell neoplasia (HP:0100728)1.75582959
94Abnormality of the nasal mucosa (HP:0000433)1.75001686
95Hemiplegia (HP:0002301)1.74951568
96Skull defect (HP:0001362)1.74905707
97Aplasia involving bones of the extremities (HP:0009825)1.74473553
98Aplasia involving bones of the upper limbs (HP:0009823)1.74473553
99Aplasia of the phalanges of the hand (HP:0009802)1.74473553
100Attention deficit hyperactivity disorder (HP:0007018)1.74176632
101Difficulty climbing stairs (HP:0003551)1.73681327
102Glossoptosis (HP:0000162)1.73118049
103Annular pancreas (HP:0001734)1.72738856
104Striae distensae (HP:0001065)1.72281531
105Increased density of long bones (HP:0006392)1.71438411
106Biconcave vertebral bodies (HP:0004586)1.70637858
107Abnormality of the diencephalon (HP:0010662)1.70294440
108Asymmetry of the thorax (HP:0001555)1.70029999
109Aplasia/Hypoplasia of the patella (HP:0006498)1.69341063
110Thin ribs (HP:0000883)1.69099068
111Mildly elevated creatine phosphokinase (HP:0008180)1.68658293
112Impulsivity (HP:0100710)1.68642014
113Truncus arteriosus (HP:0001660)1.67971236
114Partial duplication of thumb phalanx (HP:0009944)1.67721465
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67286908
116Abnormal number of incisors (HP:0011064)1.66444495
117Hypercortisolism (HP:0001578)1.66276106
118Dysmetric saccades (HP:0000641)1.65708018
119Broad phalanx (HP:0006009)1.65579967
120Increased connective tissue (HP:0009025)1.65304435
121Breast hypoplasia (HP:0003187)1.65160315
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64767873
123Preauricular skin tag (HP:0000384)1.64235391
124Arnold-Chiari malformation (HP:0002308)1.63644744
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.62767053
126Short phalanx of the thumb (HP:0009660)1.62360742
127Atresia of the external auditory canal (HP:0000413)1.61720198
128Atrophic scars (HP:0001075)1.61518506
129Cervical subluxation (HP:0003308)1.61391367
130Midface retrusion (HP:0011800)1.61134478
131Gastrointestinal carcinoma (HP:0002672)1.61096293
132Malignant gastrointestinal tract tumors (HP:0006749)1.61096293
133Broad thumb (HP:0011304)1.60879792
134Apathy (HP:0000741)1.59065565
135Vertebral arch anomaly (HP:0008438)1.58825333
136Cutaneous melanoma (HP:0012056)1.58572947
137Absent frontal sinuses (HP:0002688)1.58221858
138Global brain atrophy (HP:0002283)1.57985262
139Aplasia/Hypoplasia of the breasts (HP:0010311)1.57756777
140Abnormally folded helix (HP:0008544)1.57065951
141Abnormality of the intervertebral disk (HP:0005108)1.56757224
142Hypopigmentation of the fundus (HP:0007894)1.56698203
143Polygenic inheritance (HP:0010982)1.55765364
144Glioma (HP:0009733)1.55703062
145Radial bowing (HP:0002986)1.55677825
146Missing ribs (HP:0000921)1.55581472
147Broad long bones (HP:0005622)1.54909870
148Neoplasm of the adrenal cortex (HP:0100641)1.54706476
149Difficulty running (HP:0009046)1.54332354
150Metaphyseal cupping (HP:0003021)1.54294386
151Milia (HP:0001056)1.54284364
152Bowing of the arm (HP:0006488)1.53655496
153Bowed forearm bones (HP:0003956)1.53655496
154Broad forehead (HP:0000337)1.53330522
155Adducted thumb (HP:0001181)1.53003100
156Proximal placement of thumb (HP:0009623)1.52378243
157Bowel incontinence (HP:0002607)1.52361237
158Spastic diplegia (HP:0001264)1.51188477
159Urethral obstruction (HP:0000796)1.51114667
160Skin tags (HP:0010609)1.50714184
161Premature skin wrinkling (HP:0100678)1.50483606
162Diminished motivation (HP:0000745)1.48123390
163Frequent falls (HP:0002359)1.47567606
164Spinal muscular atrophy (HP:0007269)1.46763551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.00571644
2SMG13.99682489
3EEF2K3.95551246
4PKN23.95073813
5MAP3K103.26887567
6PRKD32.87373129
7ICK2.77440566
8CDK122.51799916
9RIPK12.41408429
10PDGFRA2.16866346
11PTK62.09926486
12ERN11.89312655
13TYRO31.82363249
14SCYL21.68335185
15NEK21.62349166
16ALK1.62123356
17TTN1.58124712
18BMX1.50041648
19SIK21.49758499
20EPHA41.46213367
21MAP3K91.44678954
22KSR21.40046066
23DDR21.39732156
24TTK1.39324810
25SIK11.36112440
26VRK21.34387403
27CDK191.33456524
28TESK11.31561251
29CAMKK11.29204647
30CAMK1G1.25819621
31BUB11.22995860
32TAOK11.20494152
33PAK41.19033033
34* MTOR1.18846709
35UHMK11.18584195
36CAMK1D1.17502744
37LRRK21.15191876
38PAK61.14108543
39CDK71.12998276
40DAPK21.08160012
41DYRK21.05155548
42MARK11.04096300
43TSSK61.01886934
44STK381.01824041
45PAK20.97944216
46RET0.97194548
47CHEK20.97005386
48PASK0.94214420
49MAP4K10.93190047
50CDK40.92120608
51PRPF4B0.91246607
52ATR0.90737564
53SRPK10.89181309
54CDK60.88270240
55TAF10.88130240
56PTK20.86656403
57PRKCH0.86369437
58LATS20.86045388
59DYRK1B0.85077674
60PDGFRB0.83817096
61LATS10.82877169
62PDK30.81255920
63PDK40.81255920
64FGFR40.80760405
65BRSK10.80245252
66CDC70.77006520
67MAP3K70.74965737
68BRAF0.73720360
69LMTK20.73464097
70CDK11A0.73030500
71CDK10.72724601
72MAP3K20.72411452
73AURKA0.72328033
74NEK10.72203331
75GRK60.71889799
76MKNK10.71079917
77MAP3K80.65590676
78BRD40.65060899
79CDK150.64701397
80NTRK30.63934662
81CDC42BPA0.62634397
82RPS6KA20.62081828
83FGFR10.60410967
84DMPK0.60343939
85RPS6KB20.58627875
86CDK180.58569038
87RPS6KL10.58144503
88RPS6KC10.58144503
89NTRK10.58055009
90NME20.58017267
91KSR10.57074603
92PRKD20.55953577
93PDK10.55766403
94MARK20.55641329
95GSK3B0.55502823
96MAPK100.52129267
97MINK10.49772286
98STK110.49491875
99EPHA20.48451083
100PLK10.48400381
101CDK140.47942770
102NTRK20.47498293
103HCK0.47463531
104FLT30.47122858
105PTK2B0.47105775
106RPS6KA10.47086082
107FGFR30.46891268
108STK100.46544537
109FGFR20.46215700
110AURKB0.45884179
111CSNK1E0.45538683
112NME10.44691774
113EPHB10.44201362
114CHEK10.43807054
115STK30.43754183
116RPS6KA60.43649312
117PDPK10.43426048
118MAPK140.43095160
119AKT10.42624227
120HIPK20.42332845
121TESK20.41368709
122TNK20.40968260
123ATM0.40365574
124CDK90.40152166
125CDK20.39266653
126JAK10.38982904
127DAPK10.38334499
128CSF1R0.38044847
129JAK20.37386461
130SGK30.37049016
131MAP3K10.36407627
132DAPK30.35980678
133MAPK90.35571651
134CDK50.35524323
135PRKD10.34816767
136RPS6KA40.34678006
137MAP2K20.34641765
138ILK0.33632691
139MAPK150.33318507
140ERBB20.33034215
141MAPK80.32669093
142EPHB20.30966747
143AKT20.29702868
144CSNK1D0.29115682
145SRC0.29038090
146PRKDC0.28296770

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.98131720
2Base excision repair_Homo sapiens_hsa034102.42415283
3Nitrogen metabolism_Homo sapiens_hsa009102.06926145
4Spliceosome_Homo sapiens_hsa030402.00495683
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.96596191
6Biosynthesis of amino acids_Homo sapiens_hsa012301.89779539
7Chronic myeloid leukemia_Homo sapiens_hsa052201.83730802
8mTOR signaling pathway_Homo sapiens_hsa041501.81407029
9Mismatch repair_Homo sapiens_hsa034301.67548792
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65387453
11Glioma_Homo sapiens_hsa052141.63366871
12Cell cycle_Homo sapiens_hsa041101.59881008
13Non-small cell lung cancer_Homo sapiens_hsa052231.55209825
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.51813798
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50872238
16Wnt signaling pathway_Homo sapiens_hsa043101.45948689
17Endometrial cancer_Homo sapiens_hsa052131.42492815
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40097509
19Type II diabetes mellitus_Homo sapiens_hsa049301.39403406
20Estrogen signaling pathway_Homo sapiens_hsa049151.39215298
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38234956
22RNA transport_Homo sapiens_hsa030131.38191164
23VEGF signaling pathway_Homo sapiens_hsa043701.36681249
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36448921
25Dorso-ventral axis formation_Homo sapiens_hsa043201.34827405
26Axon guidance_Homo sapiens_hsa043601.34062552
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.32488260
28Proteoglycans in cancer_Homo sapiens_hsa052051.28958036
29Notch signaling pathway_Homo sapiens_hsa043301.25850908
30Bladder cancer_Homo sapiens_hsa052191.24201643
31Focal adhesion_Homo sapiens_hsa045101.24044271
32Small cell lung cancer_Homo sapiens_hsa052221.22735484
33B cell receptor signaling pathway_Homo sapiens_hsa046621.19253809
34Non-homologous end-joining_Homo sapiens_hsa034501.17036850
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16993294
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14459029
37Insulin resistance_Homo sapiens_hsa049311.13753673
38Vitamin B6 metabolism_Homo sapiens_hsa007501.11863383
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09662530
40Pentose phosphate pathway_Homo sapiens_hsa000301.09646432
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09230152
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08884117
43Sulfur relay system_Homo sapiens_hsa041221.08229097
44Acute myeloid leukemia_Homo sapiens_hsa052211.05588480
45MicroRNAs in cancer_Homo sapiens_hsa052061.05340204
46Colorectal cancer_Homo sapiens_hsa052101.04758830
47* Lysine degradation_Homo sapiens_hsa003101.03318683
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02710327
49Insulin signaling pathway_Homo sapiens_hsa049101.01764145
50Glucagon signaling pathway_Homo sapiens_hsa049221.00470525
51Adherens junction_Homo sapiens_hsa045200.99288139
52Nucleotide excision repair_Homo sapiens_hsa034200.97431048
53Basal cell carcinoma_Homo sapiens_hsa052170.96199678
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95895382
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95748080
56AMPK signaling pathway_Homo sapiens_hsa041520.94966555
57Amoebiasis_Homo sapiens_hsa051460.94900333
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94071783
59Hippo signaling pathway_Homo sapiens_hsa043900.93256246
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93131928
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92628291
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.92340212
63Pancreatic cancer_Homo sapiens_hsa052120.92273693
64Long-term potentiation_Homo sapiens_hsa047200.91960201
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89877375
66mRNA surveillance pathway_Homo sapiens_hsa030150.89794514
67* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89504704
68Synaptic vesicle cycle_Homo sapiens_hsa047210.88373987
69Fatty acid biosynthesis_Homo sapiens_hsa000610.88269394
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.87647207
71Renal cell carcinoma_Homo sapiens_hsa052110.87408352
72Alcoholism_Homo sapiens_hsa050340.87182101
73ErbB signaling pathway_Homo sapiens_hsa040120.86115238
74Prolactin signaling pathway_Homo sapiens_hsa049170.85419703
75Nicotine addiction_Homo sapiens_hsa050330.84770551
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84257695
77Gastric acid secretion_Homo sapiens_hsa049710.83051159
78Endocytosis_Homo sapiens_hsa041440.82151516
79HTLV-I infection_Homo sapiens_hsa051660.80826719
80ECM-receptor interaction_Homo sapiens_hsa045120.80165433
81Fructose and mannose metabolism_Homo sapiens_hsa000510.80115857
82Gap junction_Homo sapiens_hsa045400.80073271
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79049388
84GnRH signaling pathway_Homo sapiens_hsa049120.78275329
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78063455
86Hedgehog signaling pathway_Homo sapiens_hsa043400.77991499
87Carbon metabolism_Homo sapiens_hsa012000.77529422
88Oocyte meiosis_Homo sapiens_hsa041140.77348160
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77040724
90Viral carcinogenesis_Homo sapiens_hsa052030.76524859
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76200322
92Thyroid cancer_Homo sapiens_hsa052160.75821151
93Platelet activation_Homo sapiens_hsa046110.75747153
94HIF-1 signaling pathway_Homo sapiens_hsa040660.75288719
95Toxoplasmosis_Homo sapiens_hsa051450.75198762
96Rap1 signaling pathway_Homo sapiens_hsa040150.73889151
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73516295
98Protein digestion and absorption_Homo sapiens_hsa049740.73331178
99Glutamatergic synapse_Homo sapiens_hsa047240.72975376
100Melanogenesis_Homo sapiens_hsa049160.72247158
101Fanconi anemia pathway_Homo sapiens_hsa034600.72167307
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71697773
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71357843
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70346382
105Oxytocin signaling pathway_Homo sapiens_hsa049210.69787590
106Bile secretion_Homo sapiens_hsa049760.69190423
107Cocaine addiction_Homo sapiens_hsa050300.68904191
108Cholinergic synapse_Homo sapiens_hsa047250.68827574
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68745051
110Insulin secretion_Homo sapiens_hsa049110.67905300
111Osteoclast differentiation_Homo sapiens_hsa043800.67806973
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.67514327
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67250710
114One carbon pool by folate_Homo sapiens_hsa006700.66918265
115Dopaminergic synapse_Homo sapiens_hsa047280.66665867
116Prostate cancer_Homo sapiens_hsa052150.66459994
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.66382950
118Inositol phosphate metabolism_Homo sapiens_hsa005620.62975700
119Tight junction_Homo sapiens_hsa045300.61856069
120Homologous recombination_Homo sapiens_hsa034400.61713791
121Renin secretion_Homo sapiens_hsa049240.61041287
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60910227
123Choline metabolism in cancer_Homo sapiens_hsa052310.60760293
124Thyroid hormone synthesis_Homo sapiens_hsa049180.60755049
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60630273
126Circadian entrainment_Homo sapiens_hsa047130.60234770
127Pathways in cancer_Homo sapiens_hsa052000.59784596
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59128068
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58766795
130Olfactory transduction_Homo sapiens_hsa047400.58347380
131Antigen processing and presentation_Homo sapiens_hsa046120.58233652
132Long-term depression_Homo sapiens_hsa047300.57755741
133Ribosome_Homo sapiens_hsa030100.56543660
134Pyrimidine metabolism_Homo sapiens_hsa002400.56485195
135MAPK signaling pathway_Homo sapiens_hsa040100.55951205
136Prion diseases_Homo sapiens_hsa050200.55171672
137Amphetamine addiction_Homo sapiens_hsa050310.54399243
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53842571
139Melanoma_Homo sapiens_hsa052180.49404993

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