EI24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75053016
2L-phenylalanine catabolic process (GO:0006559)6.75053016
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.59157130
4L-phenylalanine metabolic process (GO:0006558)6.59157130
5aromatic amino acid family catabolic process (GO:0009074)5.95312248
6serine family amino acid catabolic process (GO:0009071)5.76173418
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68840392
8cysteine metabolic process (GO:0006534)5.65890236
9alpha-linolenic acid metabolic process (GO:0036109)5.50090204
10kynurenine metabolic process (GO:0070189)5.45656143
11sulfur amino acid catabolic process (GO:0000098)5.39875115
12glyoxylate metabolic process (GO:0046487)5.32891945
13tryptophan catabolic process (GO:0006569)5.25466506
14indole-containing compound catabolic process (GO:0042436)5.25466506
15indolalkylamine catabolic process (GO:0046218)5.25466506
16negative regulation of fibrinolysis (GO:0051918)5.17475469
17bile acid biosynthetic process (GO:0006699)5.16087770
18urea cycle (GO:0000050)5.14494526
19urea metabolic process (GO:0019627)5.14494526
20glycine metabolic process (GO:0006544)5.02219022
21tryptophan metabolic process (GO:0006568)4.96233408
22high-density lipoprotein particle remodeling (GO:0034375)4.89307467
23regulation of mesoderm development (GO:2000380)4.87806294
24homocysteine metabolic process (GO:0050667)4.82264753
25lysine catabolic process (GO:0006554)4.82079692
26lysine metabolic process (GO:0006553)4.82079692
27peptidyl-glutamic acid carboxylation (GO:0017187)4.75431188
28protein carboxylation (GO:0018214)4.75431188
29regulation of fibrinolysis (GO:0051917)4.72916805
30serine family amino acid metabolic process (GO:0009069)4.67531819
31nitrogen cycle metabolic process (GO:0071941)4.66113575
32regulation of protein activation cascade (GO:2000257)4.62910931
33amino-acid betaine metabolic process (GO:0006577)4.60040481
34bile acid metabolic process (GO:0008206)4.55956844
35complement activation, alternative pathway (GO:0006957)4.49023308
36water-soluble vitamin biosynthetic process (GO:0042364)4.45181120
37aromatic amino acid family metabolic process (GO:0009072)4.44836883
38alpha-amino acid catabolic process (GO:1901606)4.40326716
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38181784
40regulation of translational fidelity (GO:0006450)4.37264868
41regulation of complement activation (GO:0030449)4.34667252
42serine family amino acid biosynthetic process (GO:0009070)4.33835431
43cellular ketone body metabolic process (GO:0046950)4.33304939
44negative regulation of sterol transport (GO:0032372)4.32158343
45negative regulation of cholesterol transport (GO:0032375)4.32158343
46acylglycerol homeostasis (GO:0055090)4.29249192
47triglyceride homeostasis (GO:0070328)4.29249192
48regulation of cholesterol homeostasis (GO:2000188)4.29098376
49regulation of triglyceride catabolic process (GO:0010896)4.28059338
50reverse cholesterol transport (GO:0043691)4.24288699
51tyrosine metabolic process (GO:0006570)4.17536417
52cellular amino acid catabolic process (GO:0009063)4.14402697
53glutamate metabolic process (GO:0006536)4.14059785
54cellular modified amino acid catabolic process (GO:0042219)4.13609230
55negative regulation of stress fiber assembly (GO:0051497)4.08022532
56macromolecular complex remodeling (GO:0034367)4.03147611
57plasma lipoprotein particle remodeling (GO:0034369)4.03147611
58protein-lipid complex remodeling (GO:0034368)4.03147611
59regulation of cholesterol esterification (GO:0010872)4.01596901
60plasma lipoprotein particle clearance (GO:0034381)3.97259910
61dicarboxylic acid biosynthetic process (GO:0043650)3.95060013
62regulation of mitochondrial translation (GO:0070129)3.94084218
63bile acid and bile salt transport (GO:0015721)3.93343388
64urate metabolic process (GO:0046415)3.92084022
65phospholipid efflux (GO:0033700)3.86727156
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.84734002
67drug catabolic process (GO:0042737)3.83295599
68coenzyme catabolic process (GO:0009109)3.80754668
69acetyl-CoA metabolic process (GO:0006084)3.75440188
70ketone body metabolic process (GO:1902224)3.75432909
71ethanol oxidation (GO:0006069)3.75307837
72vitamin transmembrane transport (GO:0035461)3.74620462
73biotin metabolic process (GO:0006768)3.70726597
742-oxoglutarate metabolic process (GO:0006103)3.69843326
75lung-associated mesenchyme development (GO:0060484)3.69195091
76regulation of bile acid biosynthetic process (GO:0070857)3.68956801
77DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.68742539
78negative regulation of fatty acid biosynthetic process (GO:0045717)3.66170932
79imidazole-containing compound metabolic process (GO:0052803)3.64902010
80cellular glucuronidation (GO:0052695)3.63099238
81desmosome organization (GO:0002934)3.62080398
82short-chain fatty acid metabolic process (GO:0046459)3.61105627
83aspartate family amino acid catabolic process (GO:0009068)3.59214381
84cholesterol efflux (GO:0033344)3.58584467
85negative regulation of DNA-templated transcription, elongation (GO:0032785)3.58268686
86organic acid catabolic process (GO:0016054)3.58010407
87carboxylic acid catabolic process (GO:0046395)3.58010407
88benzene-containing compound metabolic process (GO:0042537)3.57866223
89indolalkylamine metabolic process (GO:0006586)3.56603210
90arginine metabolic process (GO:0006525)3.53563754
91positive regulation of lamellipodium assembly (GO:0010592)3.53259145
92DNA damage response, signal transduction resulting in transcription (GO:0042772)3.51118824
93positive regulation of lipid catabolic process (GO:0050996)3.50239818
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.49940285
95fibrinolysis (GO:0042730)3.48579682
96pantothenate metabolic process (GO:0015939)3.48169269
97L-serine metabolic process (GO:0006563)3.43035911
98cholesterol homeostasis (GO:0042632)3.40987478
99amine catabolic process (GO:0009310)3.40687601
100cellular biogenic amine catabolic process (GO:0042402)3.40687601
101sterol homeostasis (GO:0055092)3.39778409
102plasma lipoprotein particle assembly (GO:0034377)3.39547416
103epoxygenase P450 pathway (GO:0019373)3.37659927
104heme transport (GO:0015886)3.36615053
105membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.35443201
106fatty acid beta-oxidation (GO:0006635)3.34800977
107fatty acid oxidation (GO:0019395)3.33346796
108carnitine metabolic process (GO:0009437)3.32983359
109one-carbon metabolic process (GO:0006730)3.31121379
110exogenous drug catabolic process (GO:0042738)3.30910502
111regulation of translational termination (GO:0006449)3.28635961
112positive regulation of triglyceride lipase activity (GO:0061365)3.27964538
113positive regulation of lipoprotein lipase activity (GO:0051006)3.27964538
114monocarboxylic acid catabolic process (GO:0072329)3.27212742
115positive regulation of lamellipodium organization (GO:1902745)3.26625381
116somite development (GO:0061053)3.24421572
117negative regulation of actin filament bundle assembly (GO:0032232)3.21148032
118negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.08403343
119gap junction assembly (GO:0016264)3.06217527
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02410911
121bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01914509
122mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99865815
123rRNA catabolic process (GO:0016075)2.97060091
124membrane repolarization during action potential (GO:0086011)2.96119044
125maturation of SSU-rRNA (GO:0030490)2.95951742
126regulation of translational elongation (GO:0006448)2.95122164
127epithelial cell maturation (GO:0002070)2.93483826
128regulation of hippo signaling (GO:0035330)2.90652024
129nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.90530489
130lateral sprouting from an epithelium (GO:0060601)2.85383192
131pseudouridine synthesis (GO:0001522)2.84367207
132regulation of glomerulus development (GO:0090192)2.77365180
133embryonic skeletal joint morphogenesis (GO:0060272)2.74915600
134ribosomal large subunit biogenesis (GO:0042273)2.74218052
135regulation of tight junction assembly (GO:2000810)2.73921788
136cardiac muscle cell action potential involved in contraction (GO:0086002)2.73444084
137ribosome biogenesis (GO:0042254)2.71975857
138negative regulation of cardiac muscle tissue growth (GO:0055022)2.71090700
139negative regulation of heart growth (GO:0061117)2.71090700
140regulation of DNA endoreduplication (GO:0032875)2.69923923
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69624376
142ATP synthesis coupled proton transport (GO:0015986)2.69624376
143positive regulation of glomerulus development (GO:0090193)2.68744723
144folic acid-containing compound biosynthetic process (GO:0009396)2.68109920
145ribosomal small subunit biogenesis (GO:0042274)2.67562109
146magnesium ion transport (GO:0015693)2.66323417
147ribonucleoprotein complex biogenesis (GO:0022613)2.66259243
148artery development (GO:0060840)2.65585636
149regulation of female receptivity (GO:0045924)2.65235781
150cardiac muscle cell action potential (GO:0086001)2.58262210
151tetrahydrofolate metabolic process (GO:0046653)2.57676460
152establishment of protein localization to mitochondrial membrane (GO:0090151)2.56329543
153positive regulation of organelle assembly (GO:1902117)2.56193179
154ribosome assembly (GO:0042255)2.54478775
155CENP-A containing nucleosome assembly (GO:0034080)2.51469798
156positive regulation of transcription regulatory region DNA binding (GO:2000679)2.48466996
157DNA strand elongation involved in DNA replication (GO:0006271)2.47034489
158regulation of receptor binding (GO:1900120)2.44259815
159regulation of heart rate by cardiac conduction (GO:0086091)2.44019754
160kidney mesenchyme development (GO:0072074)2.43628447
161cell migration involved in gastrulation (GO:0042074)2.42852612
162chromatin remodeling at centromere (GO:0031055)2.40751531
163DNA strand elongation (GO:0022616)2.38492157
164pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.37674917
165protein sumoylation (GO:0016925)2.35607942
166cellular component biogenesis (GO:0044085)2.34442918
167telomere maintenance via semi-conservative replication (GO:0032201)2.33522435
168metanephric mesenchyme development (GO:0072075)2.32525441
169pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.31119350
170prostate gland growth (GO:0060736)2.30788858
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30211552
172AMP metabolic process (GO:0046033)2.29889359
173response to UV-C (GO:0010225)2.28640379
174female mating behavior (GO:0060180)2.28631757
175DNA replication checkpoint (GO:0000076)2.28557758
176pteridine-containing compound biosynthetic process (GO:0042559)2.28414916
177DNA unwinding involved in DNA replication (GO:0006268)2.27960386
178morphogenesis of an epithelial fold (GO:0060571)2.26941846
179protein polyglutamylation (GO:0018095)2.26622843
180regulation of telomerase activity (GO:0051972)2.26606692
181ADP metabolic process (GO:0046031)2.25913318
182rRNA metabolic process (GO:0016072)2.24074573
183RNA localization (GO:0006403)2.23570013
184ncRNA catabolic process (GO:0034661)2.22576603
185negative regulation of cardiac muscle tissue development (GO:0055026)2.22301051
186proline biosynthetic process (GO:0006561)2.20533957
187translational termination (GO:0006415)2.20006332
188organ formation (GO:0048645)2.18852822
189nucleobase biosynthetic process (GO:0046112)2.18577766
190viral transcription (GO:0019083)2.18124962
191nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.16016637
192negative regulation of sodium ion transport (GO:0010766)2.16010533
193vitamin biosynthetic process (GO:0009110)2.15985738
194positive regulation of synapse maturation (GO:0090129)2.15749469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.33123074
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.39488126
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.61241020
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02978713
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.68700374
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.31084263
7MYC_18555785_ChIP-Seq_MESCs_Mouse4.29496145
8E2F7_22180533_ChIP-Seq_HELA_Human4.24197320
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75626904
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62136677
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03094123
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97942709
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96303032
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.92126657
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75891618
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73131769
17CLOCK_20551151_ChIP-Seq_293T_Human2.69936500
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68992584
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58182386
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57918117
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53907470
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48024855
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47381827
24XRN2_22483619_ChIP-Seq_HELA_Human2.46609930
25* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43999193
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.38273715
27ZNF263_19887448_ChIP-Seq_K562_Human2.34256624
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.17403393
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12477009
30TTF2_22483619_ChIP-Seq_HELA_Human2.09977397
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05656855
32* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1542582
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94571111
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80399599
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79915829
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79522527
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77570577
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77515608
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71059755
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70641638
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67684611
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67011257
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.66346515
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65774374
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65108615
46* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62427571
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56850127
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56021705
49* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55840132
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.54413225
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50421092
52KDM5A_27292631_Chip-Seq_BREAST_Human1.49823646
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.49585406
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49017560
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43693870
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43285116
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42021496
58GABP_19822575_ChIP-Seq_HepG2_Human1.41873852
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39805348
60MYC_18940864_ChIP-ChIP_HL60_Human1.38152552
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.37348854
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35391198
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31690780
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.30641415
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30476759
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29202086
67DCP1A_22483619_ChIP-Seq_HELA_Human1.28659612
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.28054381
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27805570
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25879517
71TBX5_21415370_ChIP-Seq_HL-1_Mouse1.24737600
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24579995
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23675694
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.23162146
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22479671
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20728761
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20703281
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20120302
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19621210
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19430937
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17587840
82ELK1_19687146_ChIP-ChIP_HELA_Human1.16621957
83AR_21909140_ChIP-Seq_LNCAP_Human1.16218283
84* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14961125
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13890012
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13294321
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11962177
88FOXP3_21729870_ChIP-Seq_TREG_Human1.11572329
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10981287
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.09388945
91ATF3_27146783_Chip-Seq_COLON_Human1.08510355
92* RACK7_27058665_Chip-Seq_MCF-7_Human1.08144047
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.07756391
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07294809
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07012855
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04389804
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03977217
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03334080
99* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02356112
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.01575668
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01542662
102GATA4_25053715_ChIP-Seq_YYC3_Human1.00824365
103* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00741663
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00718533
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00210320
106CREB1_26743006_Chip-Seq_LNCaP_Human0.99911405
107LXR_22292898_ChIP-Seq_THP-1_Human0.98620067
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97674474
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97270862
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97124115
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96805459
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.95282780
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94770629
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94236934
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.94081720
116YY1_21170310_ChIP-Seq_MESCs_Mouse0.93935327
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93710813
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93341069
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93001138
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92609050
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92184677
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92143424
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92025684
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91312839
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90535515
126GATA6_25053715_ChIP-Seq_YYC3_Human0.89716095
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89341419
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88768255
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88729526
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87865422
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87433853
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87154306
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.87057471
134* TP53_22127205_ChIP-Seq_IMR90_Human0.86150893
135VDR_23849224_ChIP-Seq_CD4+_Human0.86065582
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85760219
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85191718
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84688567
139* SOX17_20123909_ChIP-Seq_XEN_Mouse0.84657574
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84649578
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.82495378
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81806347
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81668588
144* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79119780
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.78759108
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77195019
147* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76448096
148SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75241628
149KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75110102
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.74832095
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.74560414
152* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74087396
153P68_20966046_ChIP-Seq_HELA_Human0.72298986
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72010565
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.71687635
156POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71480054
157* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71407712
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70675965
159ZFP281_18757296_ChIP-ChIP_E14_Mouse0.69592669
160FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68754453
161HTT_18923047_ChIP-ChIP_STHdh_Human0.68113931
162SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.67915461
163FOXM1_23109430_ChIP-Seq_U2OS_Human0.67638670
164ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.66683205
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.66654256
166GATA1_22025678_ChIP-Seq_K562_Human0.66490383
167SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65553233
168TRIM28_21343339_ChIP-Seq_HEK293_Human0.65092708
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65002253
170KDM2B_26808549_Chip-Seq_K562_Human0.63396857
171GATA3_24758297_ChIP-Seq_MCF-7_Human0.63263562
172UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62572133
173* CHD1_26751641_Chip-Seq_LNCaP_Human0.61851242
174NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61835939
175KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.61427917
176RUNX1_27514584_Chip-Seq_MCF-7_Human0.60783000
177TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60711744
178FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60432677
179NANOG_16518401_ChIP-PET_MESCs_Mouse0.59944223
180* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59458507
181* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.58988486
182* BCOR_27268052_Chip-Seq_Bcells_Human0.58673516
183FOXA1_25552417_ChIP-Seq_VCAP_Human0.58391531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74305892
2MP0005360_urolithiasis7.03886660
3MP0005085_abnormal_gallbladder_physiolo5.92003657
4MP0005365_abnormal_bile_salt5.84512247
5MP0008875_abnormal_xenobiotic_pharmacok4.43389885
6MP0003806_abnormal_nucleotide_metabolis3.88602095
7MP0003252_abnormal_bile_duct3.82560178
8MP0009840_abnormal_foam_cell3.81724540
9MP0000537_abnormal_urethra_morphology3.65069190
10MP0010329_abnormal_lipoprotein_level3.33309255
11MP0005646_abnormal_pituitary_gland3.00104949
12MP0005332_abnormal_amino_acid2.79967181
13MP0005083_abnormal_biliary_tract2.63629919
14MP0003283_abnormal_digestive_organ2.57035432
15MP0001666_abnormal_nutrient_absorption2.50178315
16MP0003693_abnormal_embryo_hatching2.49993624
17MP0003705_abnormal_hypodermis_morpholog2.43470770
18MP0009379_abnormal_foot_pigmentation2.42503834
19MP0002876_abnormal_thyroid_physiology2.41658838
20MP0003195_calcinosis2.31595840
21MP0000467_abnormal_esophagus_morphology2.26582775
22MP0000609_abnormal_liver_physiology2.15761662
23MP0004019_abnormal_vitamin_homeostasis2.14146484
24MP0002118_abnormal_lipid_homeostasis2.08055210
25MP0003191_abnormal_cellular_cholesterol2.03454264
26MP0002837_dystrophic_cardiac_calcinosis2.01625440
27MP0010234_abnormal_vibrissa_follicle1.81869629
28MP0003646_muscle_fatigue1.79403435
29MP0003868_abnormal_feces_composition1.78991755
30MP0005319_abnormal_enzyme/_coenzyme1.71327671
31MP0005451_abnormal_body_composition1.70231968
32MP0003937_abnormal_limbs/digits/tail_de1.68645096
33MP0004957_abnormal_blastocyst_morpholog1.65835060
34MP0003941_abnormal_skin_development1.65065744
35MP0002234_abnormal_pharynx_morphology1.58838309
36MP0006292_abnormal_olfactory_placode1.57695042
37MP0000678_abnormal_parathyroid_gland1.57310907
38MP0002282_abnormal_trachea_morphology1.56171580
39MP0003942_abnormal_urinary_system1.54553002
40MP0003938_abnormal_ear_development1.53426256
41MP0002138_abnormal_hepatobiliary_system1.51110062
42MP0000383_abnormal_hair_follicle1.51095211
43MP0000049_abnormal_middle_ear1.50504273
44MP0002160_abnormal_reproductive_system1.48834661
45MP0003111_abnormal_nucleus_morphology1.40336257
46MP0010094_abnormal_chromosome_stability1.38352098
47MP0004145_abnormal_muscle_electrophysio1.36166462
48MP0008058_abnormal_DNA_repair1.35678466
49MP0009643_abnormal_urine_homeostasis1.35375734
50MP0005584_abnormal_enzyme/coenzyme_acti1.32480324
51MP0008932_abnormal_embryonic_tissue1.31847567
52MP0004782_abnormal_surfactant_physiolog1.28880993
53MP0000613_abnormal_salivary_gland1.27724289
54MP0001346_abnormal_lacrimal_gland1.27189076
55MP0002102_abnormal_ear_morphology1.17647331
56MP0001293_anophthalmia1.17286946
57MP0009053_abnormal_anal_canal1.15153190
58MP0002098_abnormal_vibrissa_morphology1.13005162
59MP0002249_abnormal_larynx_morphology1.12412000
60MP0000598_abnormal_liver_morphology1.12411340
61MP0004130_abnormal_muscle_cell1.11023876
62MP0003890_abnormal_embryonic-extraembry1.10059842
63MP0003879_abnormal_hair_cell1.09889368
64MP0003315_abnormal_perineum_morphology1.09463921
65MP0001764_abnormal_homeostasis1.07633226
66MP0002084_abnormal_developmental_patter1.06294154
67MP0009250_abnormal_appendicular_skeleto1.03692071
68MP0001661_extended_life_span1.03658130
69MP0004197_abnormal_fetal_growth/weight/1.03555829
70MP0008775_abnormal_heart_ventricle1.02754451
71MP0002111_abnormal_tail_morphology1.01877129
72MP0004185_abnormal_adipocyte_glucose1.00985790
73MP0000566_synostosis1.00594597
74MP0000762_abnormal_tongue_morphology0.99773691
75MP0003656_abnormal_erythrocyte_physiolo0.99442668
76MP0000604_amyloidosis0.99094269
77MP0000377_abnormal_hair_follicle0.99066315
78MP0002697_abnormal_eye_size0.98760359
79MP0005666_abnormal_adipose_tissue0.97124146
80MP0003329_amyloid_beta_deposits0.96952212
81MP0003718_maternal_effect0.96400696
82MP0002736_abnormal_nociception_after0.95803281
83MP0002932_abnormal_joint_morphology0.93764252
84MP0002796_impaired_skin_barrier0.93575739
85MP0000631_abnormal_neuroendocrine_gland0.93324855
86MP0001756_abnormal_urination0.93135232
87MP0005220_abnormal_exocrine_pancreas0.92063728
88MP0001697_abnormal_embryo_size0.91954793
89MP0003077_abnormal_cell_cycle0.90486022
90MP0010030_abnormal_orbit_morphology0.90475141
91MP0002254_reproductive_system_inflammat0.90444511
92MP0004272_abnormal_basement_membrane0.89937429
93MP0000428_abnormal_craniofacial_morphol0.87767497
94MP0000681_abnormal_thyroid_gland0.86558677
95MP0010771_integument_phenotype0.86441607
96MP0002085_abnormal_embryonic_tissue0.86216723
97MP0002971_abnormal_brown_adipose0.86126056
98MP0005647_abnormal_sex_gland0.85921688
99MP0001672_abnormal_embryogenesis/_devel0.85722813
100MP0005380_embryogenesis_phenotype0.85722813
101MP0008789_abnormal_olfactory_epithelium0.85119710
102MP0005389_reproductive_system_phenotype0.83083716
103MP0000534_abnormal_ureter_morphology0.83058957
104MP0002078_abnormal_glucose_homeostasis0.82957938
105MP0009672_abnormal_birth_weight0.82704818
106MP0003011_delayed_dark_adaptation0.80184045
107MP0005248_abnormal_Harderian_gland0.79934818
108MP0005636_abnormal_mineral_homeostasis0.78078324
109MP0003755_abnormal_palate_morphology0.77814118
110MP0008007_abnormal_cellular_replicative0.76809561
111MP0005187_abnormal_penis_morphology0.76205282
112MP0002938_white_spotting0.75150612
113MP0010368_abnormal_lymphatic_system0.73617415
114MP0004134_abnormal_chest_morphology0.73514009
115MP0004885_abnormal_endolymph0.72799251
116MP0001968_abnormal_touch/_nociception0.72506388
117MP0005395_other_phenotype0.72351362
118MP0004233_abnormal_muscle_weight0.72193643
119MP0006036_abnormal_mitochondrial_physio0.71576925
120MP0005408_hypopigmentation0.71309216
121MP0009642_abnormal_blood_homeostasis0.70753784
122MP0003186_abnormal_redox_activity0.70579845
123MP0002089_abnormal_postnatal_growth/wei0.69961036
124MP0005670_abnormal_white_adipose0.69528558
125MP0003984_embryonic_growth_retardation0.69348492
126MP0001286_abnormal_eye_development0.66100153
127MP0005334_abnormal_fat_pad0.62696277
128MP0009763_increased_sensitivity_to0.60811291
129MP0003221_abnormal_cardiomyocyte_apopto0.58465203
130MP0001849_ear_inflammation0.58374307
131MP0004264_abnormal_extraembryonic_tissu0.57732213
132MP0002269_muscular_atrophy0.56933227
133MP0000579_abnormal_nail_morphology0.56601549
134MP0009697_abnormal_copulation0.56218854
135MP0005266_abnormal_metabolism0.55080814
136MP0005375_adipose_tissue_phenotype0.54694047
137MP0003453_abnormal_keratinocyte_physiol0.54467228
138MP0000747_muscle_weakness0.53970759
139MP0005376_homeostasis/metabolism_phenot0.53913164
140MP0008961_abnormal_basal_metabolism0.52894894
141MP0003690_abnormal_glial_cell0.52865346
142MP0009384_cardiac_valve_regurgitation0.49734932
143MP0003300_gastrointestinal_ulcer0.49734907
144MP0002136_abnormal_kidney_physiology0.49155273
145MP0000639_abnormal_adrenal_gland0.48702368
146MP0010352_gastrointestinal_tract_polyps0.47982914
147MP0004043_abnormal_pH_regulation0.47834790
148MP0005448_abnormal_energy_balance0.47374585
149MP0005084_abnormal_gallbladder_morpholo0.46102011
150MP0010678_abnormal_skin_adnexa0.46092051
151MP0005535_abnormal_body_temperature0.45775453
152MP0000647_abnormal_sebaceous_gland0.44856254
153MP0009780_abnormal_chondrocyte_physiolo0.44156455
154MP0006035_abnormal_mitochondrial_morpho0.44126537
155MP0003953_abnormal_hormone_level0.43209945
156MP0005501_abnormal_skin_physiology0.43072245
157MP0003119_abnormal_digestive_system0.40995297
158MP0001881_abnormal_mammary_gland0.40640232
159MP0009115_abnormal_fat_cell0.40559030
160MP0001730_embryonic_growth_arrest0.39830343
161MP0002970_abnormal_white_adipose0.39545166
162MP0005058_abnormal_lysosome_morphology0.39135978
163MP0009764_decreased_sensitivity_to0.38820372
164MP0002928_abnormal_bile_duct0.38537605
165MP0002168_other_aberrant_phenotype0.38449019
166MP0009765_abnormal_xenobiotic_induced0.38383006
167MP0001915_intracranial_hemorrhage0.38161353
168MP0001944_abnormal_pancreas_morphology0.36914152
169MP0002060_abnormal_skin_morphology0.36338067
170MP0005167_abnormal_blood-brain_barrier0.35679581

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.72248208
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.34248433
3Intrahepatic cholestasis (HP:0001406)6.27436597
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.07228750
5Xanthomatosis (HP:0000991)5.74053042
6Hyperglycinemia (HP:0002154)5.59414881
7Hypobetalipoproteinemia (HP:0003563)5.44977458
8Hyperglycinuria (HP:0003108)5.05955639
9Hyperlipoproteinemia (HP:0010980)4.92535621
10Abnormality of glycine metabolism (HP:0010895)4.84965363
11Abnormality of serine family amino acid metabolism (HP:0010894)4.84965363
12Prolonged partial thromboplastin time (HP:0003645)4.70430525
13Abnormality of the proximal phalanges of the hand (HP:0009834)4.67757298
14Hyperammonemia (HP:0001987)4.47073585
15Gout (HP:0001997)4.34224065
16Complement deficiency (HP:0004431)4.32882680
17Hypolipoproteinemia (HP:0010981)4.24590499
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.04124427
19Ketosis (HP:0001946)4.02096489
20Epidermoid cyst (HP:0200040)3.92409063
21Morphological abnormality of the middle ear (HP:0008609)3.91213421
22Hypoalphalipoproteinemia (HP:0003233)3.88591700
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84894145
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.79686377
25Abnormality of the common coagulation pathway (HP:0010990)3.60716673
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60417753
27Abnormality of the middle phalanges of the toes (HP:0010183)3.57820702
28Bilateral microphthalmos (HP:0007633)3.57064308
29Hypoglycemic coma (HP:0001325)3.55160694
30Abnormality of methionine metabolism (HP:0010901)3.46723441
31Fat malabsorption (HP:0002630)3.39227390
32Short hallux (HP:0010109)3.37139226
33Abnormality of serum amino acid levels (HP:0003112)3.34668136
34Hyperthyroidism (HP:0000836)3.21937839
35Abnormality of the intrinsic pathway (HP:0010989)3.17633102
36Synostosis involving the elbow (HP:0003938)3.17199556
37Humeroradial synostosis (HP:0003041)3.17199556
38Joint hemorrhage (HP:0005261)3.14130927
39Aplasia/Hypoplasia of the hallux (HP:0008362)3.12240059
40Abnormality of fatty-acid metabolism (HP:0004359)3.07566838
41Spastic diplegia (HP:0001264)3.06170678
42Abnormality of purine metabolism (HP:0004352)3.04155942
43Abnormality of complement system (HP:0005339)3.03462266
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.00512005
45Abnormality of nucleobase metabolism (HP:0010932)3.00201134
46Ketoacidosis (HP:0001993)2.99119459
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97070371
48Abnormality of the nasal septum (HP:0000419)2.95132336
49Short 1st metacarpal (HP:0010034)2.93081836
50Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.93081836
51Abnormality of pyrimidine metabolism (HP:0004353)2.92291517
52Hypercholesterolemia (HP:0003124)2.87255025
53Abnormality of the distal phalanges of the toes (HP:0010182)2.83055013
54Methylmalonic acidemia (HP:0002912)2.82158166
55Hepatocellular carcinoma (HP:0001402)2.79950614
56Myocardial infarction (HP:0001658)2.73436824
57Abnormality of the phalanges of the 5th finger (HP:0004213)2.73400174
58Symphalangism affecting the phalanges of the hand (HP:0009773)2.70752840
59Delayed CNS myelination (HP:0002188)2.70452251
60Short femoral neck (HP:0100864)2.67078718
61Abnormality of alanine metabolism (HP:0010916)2.61280681
62Hyperalaninemia (HP:0003348)2.61280681
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61280681
64Skin nodule (HP:0200036)2.60802716
65Increased purine levels (HP:0004368)2.60204857
66Hyperuricemia (HP:0002149)2.60204857
67Conjugated hyperbilirubinemia (HP:0002908)2.59776725
68Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.59208725
69Hyperbilirubinemia (HP:0002904)2.59014934
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.58789260
71Irritability (HP:0000737)2.56197957
72Abnormality of the 1st metacarpal (HP:0010009)2.55051075
73Malnutrition (HP:0004395)2.54489719
74Congenital, generalized hypertrichosis (HP:0004540)2.54193115
75Cutaneous melanoma (HP:0012056)2.52721112
76Abnormality of the Achilles tendon (HP:0005109)2.51899121
77Hypochromic microcytic anemia (HP:0004840)2.47444393
78Asplenia (HP:0001746)2.45720003
79Abnormal cartilage morphology (HP:0002763)2.45603354
80Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.43724731
81Steatorrhea (HP:0002570)2.43492220
82Neonatal onset (HP:0003623)2.40242172
83Dicarboxylic aciduria (HP:0003215)2.36854693
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36854693
85Metabolic acidosis (HP:0001942)2.34918031
86Lethargy (HP:0001254)2.32614392
87Sensorimotor neuropathy (HP:0007141)2.32322506
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.32284126
89Abnormality of cells of the erythroid lineage (HP:0012130)2.31241759
90Spontaneous abortion (HP:0005268)2.30117287
91Global brain atrophy (HP:0002283)2.28923539
92Conjunctival hamartoma (HP:0100780)2.28784902
93Hyperglycemia (HP:0003074)2.28519488
94Tetraplegia (HP:0002445)2.27904406
95Back pain (HP:0003418)2.27093399
96Abnormal number of incisors (HP:0011064)2.22836171
97Thyroid-stimulating hormone excess (HP:0002925)2.22331890
98Pendular nystagmus (HP:0012043)2.22014877
99Absent phalangeal crease (HP:0006109)2.21691771
100Esophageal varix (HP:0002040)2.21060958
101Abnormal number of erythroid precursors (HP:0012131)2.17241864
102Right ventricular cardiomyopathy (HP:0011663)2.17237212
103Cholelithiasis (HP:0001081)2.16427371
104Abnormality of the lower motor neuron (HP:0002366)2.14495847
105Chorioretinal atrophy (HP:0000533)2.14086259
106Abnormal gallbladder morphology (HP:0012437)2.13559454
107Synostosis of carpal bones (HP:0005048)2.11372136
108Polycythemia (HP:0001901)2.11308712
109Late onset (HP:0003584)2.11121032
110Hypoglycemic seizures (HP:0002173)2.10233187
111Fused cervical vertebrae (HP:0002949)2.07324687
112Vascular calcification (HP:0004934)2.06661327
113Aplasia/hypoplasia of the femur (HP:0005613)2.06177919
114Birth length less than 3rd percentile (HP:0003561)2.05346606
115Large for gestational age (HP:0001520)2.03502956
116Fragile nails (HP:0001808)2.02690015
117Cutaneous finger syndactyly (HP:0010554)2.02193078
118Pseudobulbar signs (HP:0002200)2.02114767
119Turricephaly (HP:0000262)2.00692874
120Fibular aplasia (HP:0002990)2.00404957
121Acanthocytosis (HP:0001927)2.00029793
122Abnormal gallbladder physiology (HP:0012438)1.96965429
123Cholecystitis (HP:0001082)1.96965429
124Meningioma (HP:0002858)1.93640874
125Methylmalonic aciduria (HP:0012120)1.91491657
126Short phalanx of the thumb (HP:0009660)1.91184914
127Cardiovascular calcification (HP:0011915)1.89831865
128Hypoplasia of the uterus (HP:0000013)1.89811760
129Enlarged kidneys (HP:0000105)1.89368419
130Palpitations (HP:0001962)1.87578637
131Atrioventricular block (HP:0001678)1.86922511
132Rickets (HP:0002748)1.85679528
133Hydroxyprolinuria (HP:0003080)1.85231408
134Abnormality of proline metabolism (HP:0010907)1.85231408
135Achilles tendon contracture (HP:0001771)1.83931878
136Broad hallux (HP:0010055)1.82123555
137Concave nail (HP:0001598)1.81700095
138Brushfield spots (HP:0001088)1.81418506
139Hyperinsulinemic hypoglycemia (HP:0000825)1.80727268
140Abnormality of subcutaneous fat tissue (HP:0001001)1.78861418
141Carpal synostosis (HP:0009702)1.78517456
142Abnormality of the lacrimal duct (HP:0011481)1.78285455
143Anophthalmia (HP:0000528)1.78023840
144Abnormal enzyme/coenzyme activity (HP:0012379)1.77053831
145Glomerulonephritis (HP:0000099)1.76704433
146Mitral stenosis (HP:0001718)1.76511458
147Hemorrhage of the eye (HP:0011885)1.76118513
148Confusion (HP:0001289)1.75214370
149Aplasia/hypoplasia of the humerus (HP:0006507)1.74561961
150Aplasia/Hypoplasia of the patella (HP:0006498)1.74327884
151Truncus arteriosus (HP:0001660)1.74305171
152Reduced antithrombin III activity (HP:0001976)1.73595635
153Microretrognathia (HP:0000308)1.73385478
154Testicular atrophy (HP:0000029)1.73276189
155Reticulocytosis (HP:0001923)1.72559072
156Short humerus (HP:0005792)1.72437332
157Cutaneous syndactyly (HP:0012725)1.71109183
158Abnormality of the gallbladder (HP:0005264)1.70646757
159Long nose (HP:0003189)1.70492405
160Alkalosis (HP:0001948)1.69464060
161Sparse eyelashes (HP:0000653)1.69183963
162Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.68827799
163Status epilepticus (HP:0002133)1.67291315
164Abnormal finger flexion creases (HP:0006143)1.67207826
165Lipid accumulation in hepatocytes (HP:0006561)1.66654787
166Lymphangioma (HP:0100764)1.66486940
167Nephrolithiasis (HP:0000787)1.65978808
168Pancreatitis (HP:0001733)1.65192232
169Oral leukoplakia (HP:0002745)1.64055928
170Abnormality of the costochondral junction (HP:0000919)1.63736802
171Reticulocytopenia (HP:0001896)1.63598612
172Squamous cell carcinoma (HP:0002860)1.63456656
173Microvesicular hepatic steatosis (HP:0001414)1.63220424
174Multiple enchondromatosis (HP:0005701)1.62857472
175Stroke (HP:0001297)1.62550655
176Vomiting (HP:0002013)1.61817386
177Absent eyelashes (HP:0000561)1.61593483
178Synostosis involving bones of the hand (HP:0004278)1.57392318
179Pancytopenia (HP:0001876)1.57015154
180Exostoses (HP:0100777)1.56939841
181Short tibia (HP:0005736)1.56579111
182Facial cleft (HP:0002006)1.56039585
183Abnormal lung lobation (HP:0002101)1.55827378
184Aplasia involving bones of the extremities (HP:0009825)1.55551650
185Aplasia involving bones of the upper limbs (HP:0009823)1.55551650
186Aplasia of the phalanges of the hand (HP:0009802)1.55551650
187Oligodontia (HP:0000677)1.54489580
188Hamartoma of the eye (HP:0010568)1.53817009
189Chromsome breakage (HP:0040012)1.53185175
190Radial bowing (HP:0002986)1.52720277
191Abnormality of the nasolacrimal system (HP:0000614)1.51681824
192Spinal cord compression (HP:0002176)1.51204511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.41249486
2LATS14.16827315
3TRIB33.98781193
4PKN23.15967894
5EIF2AK13.01761504
6LATS22.97799059
7FGFR42.91001603
8ERN12.83172994
9CDC72.69976228
10SIK12.67328309
11NME12.64010831
12NEK12.37761596
13STK162.23670718
14PBK2.13987015
15GRK12.13921132
16ERBB41.94325345
17KSR21.88275637
18NME21.86870268
19STK38L1.86729800
20ARAF1.84062328
21PHKG21.83467484
22PHKG11.83467484
23VRK21.75959286
24TLK11.75809918
25TSSK61.65275501
26PTK61.59325918
27ZAK1.58943162
28MAPKAPK31.50824492
29MAP2K41.49012048
30PAK61.48799824
31PLK41.47865463
32STK381.38272589
33PLK11.38100848
34STK31.37538160
35PIM21.36550737
36EIF2AK31.35701659
37EPHA21.34413772
38MKNK11.32364995
39MST41.32140279
40MAP3K91.28294800
41CHEK21.28111090
42RIPK11.23348815
43PDGFRA1.22373742
44MST1R1.20464868
45AURKA1.19599455
46FGFR21.18086271
47TAOK11.17856013
48PDK41.17790818
49PDK31.17790818
50IRAK31.16735353
51AKT31.15184046
52MAP3K21.15133368
53MAPK111.13458437
54CDK61.12949516
55WEE11.09879824
56PTK21.08942755
57PLK31.08387544
58ILK1.08251794
59AURKB1.06109396
60PINK11.03410661
61SRPK11.03336601
62PAK31.03302360
63MTOR1.02772866
64MET1.01744146
65TYRO31.00724428
66ABL20.99736188
67EEF2K0.99690315
68FRK0.99003916
69ICK0.98384168
70LIMK10.96008158
71NEK20.95392422
72PRKAA10.94759469
73WNK40.93485068
74CDK70.92897585
75ATR0.91552569
76DAPK20.90464127
77ALK0.89700269
78KDR0.89650962
79MAP3K100.88363541
80DYRK1B0.87529195
81RET0.87449512
82RPS6KB20.87251430
83CDK80.87116519
84MOS0.86288255
85FLT30.86157066
86TAOK30.85466188
87MAP3K70.85310883
88CAMKK10.85012990
89BMX0.84714073
90JAK20.81487119
91CSNK1G10.78302897
92EIF2AK20.76435568
93CSNK1G20.76075912
94BRAF0.75679223
95GSK3A0.75650943
96MAP3K30.74754411
97ERBB20.73235532
98MAP2K10.72961321
99PRKCI0.72778190
100CDK40.72667182
101BUB10.72490463
102CDK120.72000579
103FER0.71431450
104PAK20.69969520
105PRKCZ0.68011846
106NTRK10.67455150
107CSNK2A10.67246370
108DDR20.66984672
109NEK90.66387987
110CSNK1A1L0.66307162
111CAMK1D0.66305548
112PRKAA20.66153577
113TESK20.66124155
114PAK40.64786957
115PDPK10.64785599
116CSNK1G30.63514780
117FGFR10.63115400
118KSR10.62741133
119MKNK20.62442331
120SCYL20.61280838
121CHEK10.59867278
122PDK20.58799336
123EPHB20.58760388
124MAPKAPK50.56301309
125NUAK10.55535997
126EPHA40.54967659
127SMG10.53913161
128PASK0.53017676
129STK390.52609757
130WNK30.52383578
131BRSK20.51799071
132EPHB10.51529103
133MAP3K80.51504141
134TTK0.51056345
135RAF10.51044660
136INSRR0.50756190
137MAP2K20.50430161
138TTN0.49444304
139PAK10.49376257
140CSNK1A10.49359619
141MAP2K30.49333370
142ATM0.48660380
143CSNK1E0.47511048
144RPS6KA60.46389624
145CDK20.45848584
146CSNK2A20.45429087
147LRRK20.45400326
148PRKACG0.45235665
149ADRBK20.44693649
150PRKD30.44285879
151PNCK0.44268258
152AKT20.42773854
153DMPK0.42702429
154CDK10.42607059
155FGFR30.40921653
156GRK60.40650977
157MAP3K50.40555594
158STK100.40209143
159PDK10.40029916
160RPS6KA50.39107922
161CSNK1D0.36597952
162STK110.36236729
163MAP3K110.34680729
164PDGFRB0.33952864
165MAP3K10.33786048

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98613720
2Nitrogen metabolism_Homo sapiens_hsa009103.97374368
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31385148
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18826276
5Arginine biosynthesis_Homo sapiens_hsa002203.03770957
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92628416
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.71821291
8Fatty acid degradation_Homo sapiens_hsa000712.52112859
9DNA replication_Homo sapiens_hsa030302.49490435
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47609327
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45314561
12Tryptophan metabolism_Homo sapiens_hsa003802.44635389
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43373236
14Ribosome_Homo sapiens_hsa030102.37633876
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32350935
16Butanoate metabolism_Homo sapiens_hsa006502.30378312
17Complement and coagulation cascades_Homo sapiens_hsa046102.20539922
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20531336
19Vitamin B6 metabolism_Homo sapiens_hsa007502.10631231
20Mismatch repair_Homo sapiens_hsa034302.08624754
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02679917
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.95418144
23Fatty acid metabolism_Homo sapiens_hsa012121.94492871
24Homologous recombination_Homo sapiens_hsa034401.89486072
25PPAR signaling pathway_Homo sapiens_hsa033201.88057464
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87737642
27Nucleotide excision repair_Homo sapiens_hsa034201.86979547
28Propanoate metabolism_Homo sapiens_hsa006401.86901108
29RNA degradation_Homo sapiens_hsa030181.73775398
30Peroxisome_Homo sapiens_hsa041461.73204962
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.71732151
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67556082
33Bile secretion_Homo sapiens_hsa049761.65301440
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63901695
35RNA transport_Homo sapiens_hsa030131.63795478
36Selenocompound metabolism_Homo sapiens_hsa004501.62391979
37RNA polymerase_Homo sapiens_hsa030201.59451933
38Pyrimidine metabolism_Homo sapiens_hsa002401.58667468
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58507699
40Biosynthesis of amino acids_Homo sapiens_hsa012301.57836979
41Chemical carcinogenesis_Homo sapiens_hsa052041.56371311
42beta-Alanine metabolism_Homo sapiens_hsa004101.56077526
43Folate biosynthesis_Homo sapiens_hsa007901.53618399
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50271789
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.49406994
46Histidine metabolism_Homo sapiens_hsa003401.48657724
47Base excision repair_Homo sapiens_hsa034101.47119517
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.40996699
49Carbon metabolism_Homo sapiens_hsa012001.40651313
50Spliceosome_Homo sapiens_hsa030401.38162825
51Retinol metabolism_Homo sapiens_hsa008301.38153316
52Proteasome_Homo sapiens_hsa030501.37150138
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34185424
54Pyruvate metabolism_Homo sapiens_hsa006201.30395665
55Fat digestion and absorption_Homo sapiens_hsa049751.27553586
56Caffeine metabolism_Homo sapiens_hsa002321.26052431
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.23500513
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21300844
59Phenylalanine metabolism_Homo sapiens_hsa003601.21219292
60Vitamin digestion and absorption_Homo sapiens_hsa049771.20048069
61Oxidative phosphorylation_Homo sapiens_hsa001901.19676479
62Basal transcription factors_Homo sapiens_hsa030221.18120011
63Staphylococcus aureus infection_Homo sapiens_hsa051501.14615788
64Starch and sucrose metabolism_Homo sapiens_hsa005001.13770630
65Sulfur metabolism_Homo sapiens_hsa009201.12145335
66Tyrosine metabolism_Homo sapiens_hsa003501.06694563
67Protein export_Homo sapiens_hsa030601.05056891
68Fatty acid elongation_Homo sapiens_hsa000621.04126764
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.03877307
70Parkinsons disease_Homo sapiens_hsa050121.02632670
71Steroid biosynthesis_Homo sapiens_hsa001001.01945226
72Arginine and proline metabolism_Homo sapiens_hsa003301.01820302
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01299832
74Purine metabolism_Homo sapiens_hsa002300.99435470
75Sulfur relay system_Homo sapiens_hsa041220.98931200
76Cardiac muscle contraction_Homo sapiens_hsa042600.95907235
77Pentose phosphate pathway_Homo sapiens_hsa000300.94381771
78Lysine degradation_Homo sapiens_hsa003100.91623493
79ABC transporters_Homo sapiens_hsa020100.89819934
80Glycerolipid metabolism_Homo sapiens_hsa005610.87361264
81Cell cycle_Homo sapiens_hsa041100.86234401
82Huntingtons disease_Homo sapiens_hsa050160.83868849
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77484649
84Fatty acid biosynthesis_Homo sapiens_hsa000610.77294081
85Alzheimers disease_Homo sapiens_hsa050100.76732678
86Fanconi anemia pathway_Homo sapiens_hsa034600.74825113
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73656775
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73534766
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64898167
90* p53 signaling pathway_Homo sapiens_hsa041150.63213794
91One carbon pool by folate_Homo sapiens_hsa006700.62932065
92Basal cell carcinoma_Homo sapiens_hsa052170.61626108
93Glutathione metabolism_Homo sapiens_hsa004800.60514831
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.55620490
95N-Glycan biosynthesis_Homo sapiens_hsa005100.50664659
96Melanoma_Homo sapiens_hsa052180.48783483
97Hippo signaling pathway_Homo sapiens_hsa043900.47092974
98Oocyte meiosis_Homo sapiens_hsa041140.45908242
99mRNA surveillance pathway_Homo sapiens_hsa030150.44091820
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43337540
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43227567
102Insulin resistance_Homo sapiens_hsa049310.42302751
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41725756
104Prion diseases_Homo sapiens_hsa050200.39785287
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.39276282
106Adherens junction_Homo sapiens_hsa045200.39174807
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38717589
108Fructose and mannose metabolism_Homo sapiens_hsa000510.36407260
109Metabolic pathways_Homo sapiens_hsa011000.33905711
110AMPK signaling pathway_Homo sapiens_hsa041520.33570870
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28612563
112Glucagon signaling pathway_Homo sapiens_hsa049220.26036528
113Galactose metabolism_Homo sapiens_hsa000520.25903600
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24866061
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22640543
116mTOR signaling pathway_Homo sapiens_hsa041500.18337909
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17178087
118Bladder cancer_Homo sapiens_hsa052190.17117338
119Insulin signaling pathway_Homo sapiens_hsa049100.16037338
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.15335196
121Linoleic acid metabolism_Homo sapiens_hsa005910.12828808
122Regulation of autophagy_Homo sapiens_hsa041400.09497184
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04555851
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03491406
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01679870
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00862211
127Endometrial cancer_Homo sapiens_hsa05213-0.0896432
128FoxO signaling pathway_Homo sapiens_hsa04068-0.0895568
129Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0813322
130Mineral absorption_Homo sapiens_hsa04978-0.0726995
131Circadian rhythm_Homo sapiens_hsa04710-0.0665936
132Protein digestion and absorption_Homo sapiens_hsa04974-0.0495751
133Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0273751
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0195130
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0093242
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0056342
137Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0044236

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