EIF1AX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)4.31997699
2viral transcription (GO:0019083)4.31786071
3ribosomal small subunit biogenesis (GO:0042274)4.11565774
4nuclear pore complex assembly (GO:0051292)4.06064442
5ribosomal small subunit assembly (GO:0000028)4.03113494
6maturation of SSU-rRNA (GO:0030490)3.98864127
7nuclear pore organization (GO:0006999)3.97081756
8translational elongation (GO:0006414)3.95371392
9mitotic sister chromatid cohesion (GO:0007064)3.92652864
10DNA unwinding involved in DNA replication (GO:0006268)3.81357634
11ribosomal large subunit biogenesis (GO:0042273)3.74080020
12cellular protein complex disassembly (GO:0043624)3.72237439
13sister chromatid segregation (GO:0000819)3.69335557
14establishment of integrated proviral latency (GO:0075713)3.64561339
15* translational initiation (GO:0006413)3.64286389
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54897406
17mitotic chromosome condensation (GO:0007076)3.46904905
18formation of translation preinitiation complex (GO:0001731)3.43333354
19spliceosomal snRNP assembly (GO:0000387)3.42995796
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42294601
21cullin deneddylation (GO:0010388)3.39469557
22DNA strand elongation involved in DNA replication (GO:0006271)3.39236013
23ribonucleoprotein complex biogenesis (GO:0022613)3.39234011
24cotranslational protein targeting to membrane (GO:0006613)3.38952698
25viral life cycle (GO:0019058)3.37654135
26protein targeting to ER (GO:0045047)3.35453361
27negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33639164
28negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33639164
29negative regulation of chromosome segregation (GO:0051985)3.32931504
30mitotic spindle checkpoint (GO:0071174)3.32261083
31cellular protein complex localization (GO:0034629)3.31994583
32protein complex disassembly (GO:0043241)3.31804752
33negative regulation of microtubule polymerization (GO:0031115)3.28554338
34regulation of DNA endoreduplication (GO:0032875)3.23784144
35macromolecular complex disassembly (GO:0032984)3.22129630
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22035668
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22011361
38DNA replication initiation (GO:0006270)3.21611563
39transcription from mitochondrial promoter (GO:0006390)3.20894022
40nucleobase biosynthetic process (GO:0046112)3.18557374
41protein localization to kinetochore (GO:0034501)3.17566938
42protein deneddylation (GO:0000338)3.17514538
43protein localization to endoplasmic reticulum (GO:0070972)3.17297224
44CENP-A containing nucleosome assembly (GO:0034080)3.16695390
45DNA strand elongation (GO:0022616)3.16399072
46double-strand break repair via nonhomologous end joining (GO:0006303)3.15141629
47non-recombinational repair (GO:0000726)3.15141629
48regulation of centriole replication (GO:0046599)3.15100608
49regulation of chromosome segregation (GO:0051983)3.15014937
50mitotic spindle assembly checkpoint (GO:0007094)3.14116580
51chromatin remodeling at centromere (GO:0031055)3.13826402
52establishment of chromosome localization (GO:0051303)3.13578727
53regulation of mitochondrial translation (GO:0070129)3.13465514
54spindle assembly checkpoint (GO:0071173)3.13255858
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12918293
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12918293
57kinetochore assembly (GO:0051382)3.12792523
58DNA damage response, detection of DNA damage (GO:0042769)3.11586960
59peptidyl-arginine omega-N-methylation (GO:0035247)3.11251690
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.10124039
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07972406
62spliceosomal complex assembly (GO:0000245)3.07183004
63DNA replication-dependent nucleosome assembly (GO:0006335)3.06598601
64DNA replication-dependent nucleosome organization (GO:0034723)3.06598601
65chaperone-mediated protein transport (GO:0072321)3.06054075
66mitotic G2/M transition checkpoint (GO:0044818)3.04776131
67mitotic metaphase plate congression (GO:0007080)3.04775548
68RNA-dependent DNA replication (GO:0006278)3.04251410
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03723572
70rRNA modification (GO:0000154)3.01051620
71regulation of mitotic sister chromatid separation (GO:0010965)3.01043235
72regulation of mitotic sister chromatid segregation (GO:0033047)3.01043235
73regulation of sister chromatid segregation (GO:0033045)3.01043235
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.00535695
75folic acid-containing compound biosynthetic process (GO:0009396)3.00459031
76ribosome biogenesis (GO:0042254)2.99919119
77regulation of translational termination (GO:0006449)2.98715289
78mitotic nuclear envelope disassembly (GO:0007077)2.98679020
79pore complex assembly (GO:0046931)2.98517663
80pseudouridine synthesis (GO:0001522)2.96696224
81telomere maintenance via semi-conservative replication (GO:0032201)2.96518582
82telomere maintenance via telomere lengthening (GO:0010833)2.95937893
83purine nucleobase biosynthetic process (GO:0009113)2.95919593
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95802964
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95619569
86ATP synthesis coupled proton transport (GO:0015986)2.95619569
87termination of RNA polymerase II transcription (GO:0006369)2.93554800
88DNA replication-independent nucleosome assembly (GO:0006336)2.92122580
89DNA replication-independent nucleosome organization (GO:0034724)2.92122580
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91902429
91negative regulation of RNA splicing (GO:0033119)2.91018577
92proteasome assembly (GO:0043248)2.90933579
93regulation of centrosome cycle (GO:0046605)2.90562075
94regulation of translational fidelity (GO:0006450)2.90076532
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89879648
96peptidyl-arginine methylation (GO:0018216)2.88034064
97peptidyl-arginine N-methylation (GO:0035246)2.88034064
98DNA ligation (GO:0006266)2.87770628
99negative regulation of mRNA processing (GO:0050686)2.87243291
100* translation (GO:0006412)2.87195657
101rRNA processing (GO:0006364)2.87153018
102regulation of helicase activity (GO:0051095)2.86942112
103ATP-dependent chromatin remodeling (GO:0043044)2.86655645
104regulation of spindle organization (GO:0090224)2.86002215
105telomere maintenance via telomerase (GO:0007004)2.85452852
106synaptic vesicle maturation (GO:0016188)2.85010537
107histone exchange (GO:0043486)2.84842075
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82209703
109IMP biosynthetic process (GO:0006188)2.81785426
110synaptic vesicle exocytosis (GO:0016079)2.81342934
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80470997
112negative regulation of ligase activity (GO:0051352)2.80470997
113cellular component biogenesis (GO:0044085)2.79791703
114ribosome assembly (GO:0042255)2.79642120
115DNA replication checkpoint (GO:0000076)2.78974362
116histone arginine methylation (GO:0034969)2.78393653
117protein complex localization (GO:0031503)2.78356740
118deoxyribonucleotide biosynthetic process (GO:0009263)2.77906740
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.76954450
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75930297
121rRNA metabolic process (GO:0016072)2.74427694
122DNA deamination (GO:0045006)2.73237483
123glutamate secretion (GO:0014047)2.72544492
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70522139
125IMP metabolic process (GO:0046040)2.68051093
126cell cycle G1/S phase transition (GO:0044843)2.67414967
127G1/S transition of mitotic cell cycle (GO:0000082)2.67414967
128establishment of viral latency (GO:0019043)2.66780229
129deoxyribose phosphate biosynthetic process (GO:0046385)2.66116472
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.66116472
131de novo protein folding (GO:0006458)2.63474639
132protein localization to chromosome, centromeric region (GO:0071459)2.63441099
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.61929723
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.61761202
135termination of RNA polymerase III transcription (GO:0006386)2.61761202
136nucleobase-containing small molecule interconversion (GO:0015949)2.59776172
137mitotic recombination (GO:0006312)2.59306433
138mitotic sister chromatid segregation (GO:0000070)2.58351584
139spindle checkpoint (GO:0031577)2.58047908
140kinetochore organization (GO:0051383)2.57957651
141telomere maintenance via recombination (GO:0000722)2.56613959
142attachment of spindle microtubules to kinetochore (GO:0008608)2.56352926
143positive regulation of ligase activity (GO:0051351)2.55950650
144metaphase plate congression (GO:0051310)2.55865848
145negative regulation of sister chromatid segregation (GO:0033046)2.54147359
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.54147359
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54147359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77640021
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.94746382
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96362219
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55857208
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.50272970
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.42296627
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38136588
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.15174484
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06393107
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.06168512
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.98044837
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94559669
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92103754
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.91357373
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86451904
16XRN2_22483619_ChIP-Seq_HELA_Human2.66479569
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56234386
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53573568
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45585913
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33109336
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29770543
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26568683
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19233184
24TTF2_22483619_ChIP-Seq_HELA_Human2.16901307
25AR_21909140_ChIP-Seq_LNCAP_Human2.13420321
26VDR_23849224_ChIP-Seq_CD4+_Human2.01465762
27DCP1A_22483619_ChIP-Seq_HELA_Human1.99535822
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98129285
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94986021
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91528082
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90152063
32EZH2_22144423_ChIP-Seq_EOC_Human1.82721007
33ELK1_19687146_ChIP-ChIP_HELA_Human1.82588269
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76068307
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75668962
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73091570
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72538934
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.71977283
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70694187
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70472346
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69610154
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68709781
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68529490
44GABP_19822575_ChIP-Seq_HepG2_Human1.67457730
45FOXP3_21729870_ChIP-Seq_TREG_Human1.58947017
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52734317
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51934026
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48987570
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40388736
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35237199
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33542177
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.32737668
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32453751
54MYC_18940864_ChIP-ChIP_HL60_Human1.30714751
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28731293
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28424410
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24383865
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22575737
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22221375
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20508482
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20294250
62TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16228885
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.16160670
64FUS_26573619_Chip-Seq_HEK293_Human1.15169203
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13775241
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13036051
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.12912047
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12554149
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12028752
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11754502
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.11537685
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10655988
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10512562
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06987825
75ZNF274_21170338_ChIP-Seq_K562_Hela1.06265923
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05105187
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.03146939
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02476362
79KDM5A_27292631_Chip-Seq_BREAST_Human1.02322054
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02251102
81CIITA_25753668_ChIP-Seq_RAJI_Human1.00668298
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99836554
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98367413
84ZNF263_19887448_ChIP-Seq_K562_Human0.98064093
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97720314
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.97067322
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96984747
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.93127580
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91709343
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90858095
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89149355
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88410196
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88286036
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88286036
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88286036
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86831930
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85157327
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84698691
99EWS_26573619_Chip-Seq_HEK293_Human0.84551075
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.83824022
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83628692
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83088795
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82761882
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80650572
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79889766
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79620362
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78615300
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.77972223
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77667810
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77342120
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77263944
112CHD1_26751641_Chip-Seq_LNCaP_Human0.76559833
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76535461
114TAF15_26573619_Chip-Seq_HEK293_Human0.75346339
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74768667
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.74250050
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73327528
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69014590
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67222488
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66843254
121* TFEB_21752829_ChIP-Seq_HELA_Human0.66148080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.01589935
2MP0003941_abnormal_skin_development3.07249024
3MP0004957_abnormal_blastocyst_morpholog3.06386470
4MP0003693_abnormal_embryo_hatching2.96059370
5MP0003123_paternal_imprinting2.92371492
6MP0009379_abnormal_foot_pigmentation2.90607601
7MP0003880_abnormal_central_pattern2.89964124
8MP0010094_abnormal_chromosome_stability2.63051780
9MP0003635_abnormal_synaptic_transmissio2.40769822
10MP0003111_abnormal_nucleus_morphology2.31866062
11MP0004270_analgesia2.26351113
12MP0001968_abnormal_touch/_nociception2.25971742
13MP0003077_abnormal_cell_cycle2.17217272
14MP0008932_abnormal_embryonic_tissue2.08405412
15MP0009697_abnormal_copulation2.02550044
16MP0002734_abnormal_mechanical_nocicepti1.97672957
17MP0002063_abnormal_learning/memory/cond1.92621050
18MP0000537_abnormal_urethra_morphology1.90344365
19MP0002735_abnormal_chemical_nociception1.89313822
20MP0002736_abnormal_nociception_after1.88564017
21MP0009745_abnormal_behavioral_response1.85880313
22MP0008877_abnormal_DNA_methylation1.80134681
23MP0001529_abnormal_vocalization1.71896611
24MP0006292_abnormal_olfactory_placode1.69550891
25MP0009672_abnormal_birth_weight1.67315904
26MP0002064_seizures1.65667777
27MP0009046_muscle_twitch1.63061587
28MP0002938_white_spotting1.60480639
29MP0003937_abnormal_limbs/digits/tail_de1.60390325
30MP0005423_abnormal_somatic_nervous1.57839594
31MP0000778_abnormal_nervous_system1.55315038
32MP0001293_anophthalmia1.53452275
33MP0002184_abnormal_innervation1.52720538
34MP0004811_abnormal_neuron_physiology1.52360865
35MP0003806_abnormal_nucleotide_metabolis1.52242803
36MP0001730_embryonic_growth_arrest1.48836899
37MP0008058_abnormal_DNA_repair1.45421520
38MP0002572_abnormal_emotion/affect_behav1.43921933
39MP0002733_abnormal_thermal_nociception1.40716575
40MP0002272_abnormal_nervous_system1.38627366
41MP0003121_genomic_imprinting1.36006721
42MP0000579_abnormal_nail_morphology1.35001110
43MP0002796_impaired_skin_barrier1.34383073
44MP0000350_abnormal_cell_proliferation1.32890846
45MP0001188_hyperpigmentation1.32300840
46MP0010307_abnormal_tumor_latency1.31636576
47MP0002697_abnormal_eye_size1.30968257
48MP0002088_abnormal_embryonic_growth/wei1.28562965
49MP0002877_abnormal_melanocyte_morpholog1.27697628
50MP0008007_abnormal_cellular_replicative1.26573581
51MP0001970_abnormal_pain_threshold1.26284894
52MP0000955_abnormal_spinal_cord1.25800742
53MP0004145_abnormal_muscle_electrophysio1.25307873
54MP0006036_abnormal_mitochondrial_physio1.24382243
55MP0002067_abnormal_sensory_capabilities1.23196754
56MP0005499_abnormal_olfactory_system1.22767421
57MP0005394_taste/olfaction_phenotype1.22767421
58MP0010030_abnormal_orbit_morphology1.20762965
59MP0003315_abnormal_perineum_morphology1.20272073
60MP0010234_abnormal_vibrissa_follicle1.18369502
61MP0008789_abnormal_olfactory_epithelium1.18212285
62MP0003890_abnormal_embryonic-extraembry1.17869760
63MP0005386_behavior/neurological_phenoty1.15733197
64MP0004924_abnormal_behavior1.15733197
65MP0003186_abnormal_redox_activity1.13538748
66MP0004233_abnormal_muscle_weight1.11070290
67MP0001697_abnormal_embryo_size1.10070398
68MP0003861_abnormal_nervous_system1.09884737
69MP0001286_abnormal_eye_development1.09612427
70MP0001486_abnormal_startle_reflex1.09534299
71MP0002233_abnormal_nose_morphology1.07603612
72MP0002751_abnormal_autonomic_nervous1.07132453
73MP0006276_abnormal_autonomic_nervous1.06817293
74MP0001440_abnormal_grooming_behavior1.03748026
75MP0002882_abnormal_neuron_morphology1.00597627
76MP0002152_abnormal_brain_morphology1.00575463
77MP0005187_abnormal_penis_morphology0.99800092
78MP0002557_abnormal_social/conspecific_i0.99444627
79MP0003136_yellow_coat_color0.99359508
80MP0009703_decreased_birth_body0.98602465
81MP0002085_abnormal_embryonic_tissue0.98537495
82MP0001905_abnormal_dopamine_level0.97834711
83MP0006035_abnormal_mitochondrial_morpho0.97367356
84MP0000313_abnormal_cell_death0.97354661
85MP0008569_lethality_at_weaning0.96976901
86MP0005501_abnormal_skin_physiology0.96845439
87MP0003755_abnormal_palate_morphology0.96555886
88MP0002086_abnormal_extraembryonic_tissu0.96210525
89MP0001177_atelectasis0.96201346
90MP0002080_prenatal_lethality0.95929522
91MP0003787_abnormal_imprinting0.95779649
92MP0002234_abnormal_pharynx_morphology0.95424136
93MP0000762_abnormal_tongue_morphology0.93820860
94MP0000372_irregular_coat_pigmentation0.93499018
95MP0002084_abnormal_developmental_patter0.92634548
96MP0002653_abnormal_ependyma_morphology0.92530730
97MP0008057_abnormal_DNA_replication0.92312709
98MP0002066_abnormal_motor_capabilities/c0.91544478
99MP0001299_abnormal_eye_distance/0.91387582
100MP0002111_abnormal_tail_morphology0.90990860
101MP0003119_abnormal_digestive_system0.90183294
102MP0009053_abnormal_anal_canal0.88800792
103MP0003122_maternal_imprinting0.88059775
104MP0004215_abnormal_myocardial_fiber0.87971762
105MP0001346_abnormal_lacrimal_gland0.87478880
106MP0001485_abnormal_pinna_reflex0.86836689
107MP0002102_abnormal_ear_morphology0.86192547
108MP0004858_abnormal_nervous_system0.85646852
109MP0000751_myopathy0.84922874
110MP0003567_abnormal_fetal_cardiomyocyte0.84582269
111MP0002160_abnormal_reproductive_system0.84161682
112MP0000428_abnormal_craniofacial_morphol0.83872737
113MP0001672_abnormal_embryogenesis/_devel0.83270077
114MP0005380_embryogenesis_phenotype0.83270077
115MP0009250_abnormal_appendicular_skeleto0.83163006
116MP0000631_abnormal_neuroendocrine_gland0.82164006
117MP0003942_abnormal_urinary_system0.82136949
118MP0002638_abnormal_pupillary_reflex0.79921335
119MP0000358_abnormal_cell_content/0.79778481
120MP0003385_abnormal_body_wall0.79275254
121MP0003221_abnormal_cardiomyocyte_apopto0.79240980
122MP0001929_abnormal_gametogenesis0.77481847
123MP0001881_abnormal_mammary_gland0.76685394
124MP0002092_abnormal_eye_morphology0.76345331
125MP0002081_perinatal_lethality0.76157044
126MP0000647_abnormal_sebaceous_gland0.75651180
127MP0010352_gastrointestinal_tract_polyps0.75608569
128MP0005623_abnormal_meninges_morphology0.75497327
129MP0001145_abnormal_male_reproductive0.74818755
130MP0004142_abnormal_muscle_tone0.74656771
131MP0006072_abnormal_retinal_apoptosis0.74653390
132MP0003718_maternal_effect0.74647261
133MP0003786_premature_aging0.74448536
134MP0000049_abnormal_middle_ear0.73925300
135MP0004133_heterotaxia0.73921268
136MP0003329_amyloid_beta_deposits0.73313771
137MP0004197_abnormal_fetal_growth/weight/0.72613462
138MP0000747_muscle_weakness0.71615444
139MP0001348_abnormal_lacrimal_gland0.70627028
140MP0000653_abnormal_sex_gland0.69928631
141MP0005408_hypopigmentation0.68983124
142MP0003935_abnormal_craniofacial_develop0.68576712
143MP0003984_embryonic_growth_retardation0.67797852
144MP0002752_abnormal_somatic_nervous0.67742006
145MP0002210_abnormal_sex_determination0.67456851
146MP0000627_abnormal_mammary_gland0.65259953
147MP0004782_abnormal_surfactant_physiolog0.65186152
148MP0002009_preneoplasia0.62715169
149MP0000432_abnormal_head_morphology0.61918284
150MP0002396_abnormal_hematopoietic_system0.61223226
151MP0002177_abnormal_outer_ear0.60808258
152MP0002114_abnormal_axial_skeleton0.58401634

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.39589460
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89027640
3Chromsome breakage (HP:0040012)3.88038784
4Colon cancer (HP:0003003)3.72853600
5Focal motor seizures (HP:0011153)3.61820313
6Abnormality of cells of the erythroid lineage (HP:0012130)3.48199890
7Birth length less than 3rd percentile (HP:0003561)3.41630799
8Shoulder girdle muscle weakness (HP:0003547)3.21358940
9Abnormality of chromosome stability (HP:0003220)3.17901923
10Abnormality of glycolysis (HP:0004366)3.17739408
11Increased serum pyruvate (HP:0003542)3.17739408
12Volvulus (HP:0002580)3.16184698
13Meckel diverticulum (HP:0002245)2.98844918
14Abnormal number of erythroid precursors (HP:0012131)2.94782724
15Abnormality of the ileum (HP:0001549)2.89272939
16Abnormality of the preputium (HP:0100587)2.88089468
17Abnormality of methionine metabolism (HP:0010901)2.80956185
18Abnormal lung lobation (HP:0002101)2.75786179
19Acute necrotizing encephalopathy (HP:0006965)2.74450796
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.72438218
21Reticulocytopenia (HP:0001896)2.70646375
22Cerebral hypomyelination (HP:0006808)2.64459337
23Abnormal mitochondria in muscle tissue (HP:0008316)2.58022511
24Nephroblastoma (Wilms tumor) (HP:0002667)2.57767780
25Pelvic girdle muscle weakness (HP:0003749)2.57672646
26Visual hallucinations (HP:0002367)2.56109729
27Embryonal renal neoplasm (HP:0011794)2.56031279
28Increased nuchal translucency (HP:0010880)2.51458372
29Abnormality of the labia minora (HP:0012880)2.48845465
30Abnormality of the musculature of the pelvis (HP:0001469)2.43676174
31Abnormality of the hip-girdle musculature (HP:0001445)2.43676174
32Breast hypoplasia (HP:0003187)2.43315307
33Progressive macrocephaly (HP:0004481)2.41995108
34Megaloblastic anemia (HP:0001889)2.39950193
35Single umbilical artery (HP:0001195)2.39909526
36Abnormality of the fetal cardiovascular system (HP:0010948)2.39909526
37Abnormal umbilical cord blood vessels (HP:0011403)2.39909526
38Papilledema (HP:0001085)2.35940279
39Abnormality of alanine metabolism (HP:0010916)2.35052594
40Hyperalaninemia (HP:0003348)2.35052594
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35052594
42Focal seizures (HP:0007359)2.34836323
43Glossoptosis (HP:0000162)2.33741817
44Broad-based gait (HP:0002136)2.32975959
45Amyotrophic lateral sclerosis (HP:0007354)2.31189357
46Duodenal stenosis (HP:0100867)2.29536650
47Small intestinal stenosis (HP:0012848)2.29536650
48Mitochondrial inheritance (HP:0001427)2.26851739
49Postnatal microcephaly (HP:0005484)2.26578560
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25153806
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.24468313
52Cerebral edema (HP:0002181)2.23165773
53Macrocytic anemia (HP:0001972)2.22506974
54Abnormality of the umbilical cord (HP:0010881)2.21125701
55Increased CSF lactate (HP:0002490)2.19266155
56Absent radius (HP:0003974)2.13596510
57Lipid accumulation in hepatocytes (HP:0006561)2.13265628
58Progressive cerebellar ataxia (HP:0002073)2.13121602
59Oral leukoplakia (HP:0002745)2.12948016
60Epileptic encephalopathy (HP:0200134)2.11409935
61Triphalangeal thumb (HP:0001199)2.10424360
62Abnormality of serum amino acid levels (HP:0003112)2.09660912
63Medulloblastoma (HP:0002885)2.09089282
64Atonic seizures (HP:0010819)2.08108432
65Neoplasm of the peripheral nervous system (HP:0100007)2.06989228
66Rhabdomyosarcoma (HP:0002859)2.05936447
67Termporal pattern (HP:0011008)2.05570623
68Insidious onset (HP:0003587)2.05570623
69Abnormality of the duodenum (HP:0002246)2.05498360
70Poor eye contact (HP:0000817)2.03142494
71Absence seizures (HP:0002121)2.02130891
72Pancreatic islet-cell hyperplasia (HP:0004510)2.01026503
73Facial cleft (HP:0002006)2.00654914
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98524808
75Aplasia involving forearm bones (HP:0009822)1.97855709
76Absent forearm bone (HP:0003953)1.97855709
77Microvesicular hepatic steatosis (HP:0001414)1.97210568
78Pallor (HP:0000980)1.93920482
79Patellar aplasia (HP:0006443)1.93749923
80Myotonia (HP:0002486)1.92313591
81Impaired vibration sensation in the lower limbs (HP:0002166)1.92149486
82Short middle phalanx of the 5th finger (HP:0004220)1.91999654
83Glioma (HP:0009733)1.91345968
84Urinary urgency (HP:0000012)1.90525224
85Horseshoe kidney (HP:0000085)1.90275571
86Cortical dysplasia (HP:0002539)1.89538592
87Leukodystrophy (HP:0002415)1.88863490
88Hypoglycemic coma (HP:0001325)1.88645012
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.87943927
90Carpal bone hypoplasia (HP:0001498)1.87872605
91Neoplasm of the colon (HP:0100273)1.87455140
92Unsteady gait (HP:0002317)1.87177026
93Neuroblastic tumors (HP:0004376)1.87007569
94Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87007569
95Neuroblastoma (HP:0003006)1.87007569
96Primitive neuroectodermal tumor (HP:0030065)1.87007569
97Abnormalities of placenta or umbilical cord (HP:0001194)1.86800204
98Hepatocellular necrosis (HP:0001404)1.86465621
99Myelodysplasia (HP:0002863)1.85731490
100Choanal atresia (HP:0000453)1.85494084
101Delusions (HP:0000746)1.85373464
102Proximal placement of thumb (HP:0009623)1.84923418
103Abnormal number of incisors (HP:0011064)1.84723235
104Acute encephalopathy (HP:0006846)1.84035806
105Abnormality of the carotid arteries (HP:0005344)1.83324697
106Stenosis of the external auditory canal (HP:0000402)1.83193920
107Aplasia/Hypoplasia of the patella (HP:0006498)1.83108764
108Gout (HP:0001997)1.83054465
109Degeneration of anterior horn cells (HP:0002398)1.81894630
110Abnormality of the anterior horn cell (HP:0006802)1.81894630
111Atresia of the external auditory canal (HP:0000413)1.81061335
112Reduced antithrombin III activity (HP:0001976)1.80120507
113Megalencephaly (HP:0001355)1.78074412
114Increased hepatocellular lipid droplets (HP:0006565)1.77746400
115Deviation of the thumb (HP:0009603)1.77546857
116Sparse eyelashes (HP:0000653)1.76998895
117Action tremor (HP:0002345)1.76784959
118Emotional lability (HP:0000712)1.76711035
119CNS hypomyelination (HP:0003429)1.76571590
120Neuroendocrine neoplasm (HP:0100634)1.76466697
121Inappropriate behavior (HP:0000719)1.76178020
122Abnormality of the septum pellucidum (HP:0007375)1.75519602
123Dialeptic seizures (HP:0011146)1.75490081
124Progressive muscle weakness (HP:0003323)1.74726441
125Abnormality of homocysteine metabolism (HP:0010919)1.73480425
126Homocystinuria (HP:0002156)1.73480425
127Abnormality of the lower motor neuron (HP:0002366)1.72554943
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72425086
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72425086
130Irregular epiphyses (HP:0010582)1.72247089
131Adenoma sebaceum (HP:0009720)1.72103504
132Angiofibromas (HP:0010615)1.72103504
133Hyperinsulinemic hypoglycemia (HP:0000825)1.71626071
134Trismus (HP:0000211)1.71505225
135Pheochromocytoma (HP:0002666)1.70722414
136Sensory axonal neuropathy (HP:0003390)1.70276892
137Exercise intolerance (HP:0003546)1.69227013
138Methylmalonic acidemia (HP:0002912)1.69217394
139Exercise-induced muscle cramps (HP:0003710)1.68996246
140Absent thumb (HP:0009777)1.68540375
141Increased serum lactate (HP:0002151)1.67518512
142Aplastic anemia (HP:0001915)1.66754589
143Limb dystonia (HP:0002451)1.66107930
144Calcaneovalgus deformity (HP:0001848)1.65108413
145Mutism (HP:0002300)1.64931349
146Hypoglycemic seizures (HP:0002173)1.64780041
147Sloping forehead (HP:0000340)1.64153438
148Microglossia (HP:0000171)1.64043626
149Rough bone trabeculation (HP:0100670)1.60816715
150Ectopic kidney (HP:0000086)1.59826811
151Septo-optic dysplasia (HP:0100842)1.59461210
152Selective tooth agenesis (HP:0001592)1.59389634
153Bifid tongue (HP:0010297)1.59241826
154Microretrognathia (HP:0000308)1.59117431
155Absent septum pellucidum (HP:0001331)1.58991276
156Deformed tarsal bones (HP:0008119)1.58843397
157Abnormality of the astrocytes (HP:0100707)1.58568935
158Astrocytoma (HP:0009592)1.58568935
159Cafe-au-lait spot (HP:0000957)1.57601957
160Urinary bladder sphincter dysfunction (HP:0002839)1.57146618
161Ankle clonus (HP:0011448)1.57102348
162Multiple enchondromatosis (HP:0005701)1.53745561
163Amblyopia (HP:0000646)1.53410826
164Generalized tonic-clonic seizures (HP:0002069)1.51011590
165Lissencephaly (HP:0001339)1.50298720
166Fetal akinesia sequence (HP:0001989)1.50254586
167Facial hemangioma (HP:0000329)1.49694070
168Ependymoma (HP:0002888)1.47687270
169Annular pancreas (HP:0001734)1.47401912
170Gaze-evoked nystagmus (HP:0000640)1.45741000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.27624098
2BUB13.25910231
3NEK12.91455422
4MARK12.91421804
5CDC72.90137690
6WEE12.87692408
7EIF2AK12.55686619
8MINK12.18287672
9MST42.17238472
10PLK22.05689703
11CCNB11.97862561
12MAP3K91.94808645
13LATS21.92175119
14NME21.91389800
15LIMK11.90844273
16SCYL21.90782578
17PDK21.83897785
18CDK191.74461440
19BRSK11.71753968
20TESK21.71599578
21NTRK31.70987298
22PLK31.69896686
23TSSK61.68660507
24MKNK11.64913215
25TRIM281.64308305
26SRPK11.63407868
27TAF11.60303794
28VRK21.58893198
29NME11.58124041
30MAP3K41.54861578
31MAP3K121.40585679
32MAP2K71.37546447
33TLK11.37512398
34TESK11.34380618
35CASK1.34301423
36ZAK1.32413425
37EPHA41.28739540
38ERBB31.28429996
39PAK61.26115286
40CDK141.25093538
41PLK11.24832215
42BRSK21.23942562
43TNIK1.23471004
44AURKA1.19810426
45VRK11.19621059
46KSR21.18524714
47KSR11.16948276
48EIF2AK31.13781656
49CDK181.13712853
50PNCK1.12871239
51DAPK11.12361819
52CDK151.12111281
53LATS11.06808713
54GRK51.05181736
55CDK11A1.04619500
56DYRK21.03405199
57EIF2AK21.00246297
58STK30.99032584
59MAP3K100.98929392
60STK38L0.96223527
61ARAF0.95642530
62ACVR1B0.95412316
63BMPR1B0.94121166
64ERBB40.92007582
65AURKB0.91882559
66WNK30.90850286
67TTK0.87819175
68MAPK130.87758301
69NEK20.87458797
70NUAK10.87122547
71CAMKK10.86266414
72ALK0.85423727
73DAPK20.84808741
74MAP2K40.82543648
75ATM0.81444561
76CDK70.81271290
77PDK30.81058336
78PDK40.81058336
79PLK40.79665699
80UHMK10.78761748
81PASK0.78330200
82BRAF0.76099938
83MKNK20.75949308
84ILK0.74748180
85CHEK20.74371068
86PRKCG0.69885964
87RAF10.68233556
88PHKG20.67613382
89PHKG10.67613382
90BCR0.67041847
91STK160.66766126
92CDK80.65851220
93CDK50.64939856
94NTRK20.64595528
95PAK40.64030179
96MAP3K80.62662923
97CSNK1G20.62556209
98DYRK30.62087676
99ATR0.61118674
100DMPK0.60113486
101CSNK1G10.60039420
102PAK10.58671621
103STK40.58609183
104CDK30.58551452
105NTRK10.58110712
106STK390.56935229
107CLK10.56815646
108CHEK10.56331538
109STK240.55674110
110RPS6KB20.55659713
111CSNK1E0.52196021
112CSNK2A20.51367176
113CSNK1G30.50940262
114DAPK30.49607139
115CDK20.48428907
116CAMKK20.47535521
117MOS0.46707575
118OXSR10.46025300
119PRKDC0.45495211
120LRRK20.44655632
121CDK10.43803418
122CSNK2A10.41679788
123FGFR10.40976348
124MAP3K20.40303400
125PIM20.39698651
126PRKCI0.39555325
127CDK60.39444453
128AKT20.38795433
129ABL20.38212875
130RPS6KA40.37629161
131TGFBR10.37356758
132BRD40.35038468
133MAPKAPK50.33994351
134CDK40.32133485
135MST1R0.31206165
136CSNK1A1L0.25638868
137MELK0.23097993

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.88959568
2DNA replication_Homo sapiens_hsa030303.31289522
3Proteasome_Homo sapiens_hsa030503.24368351
4Mismatch repair_Homo sapiens_hsa034302.80798785
5Spliceosome_Homo sapiens_hsa030402.77862869
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75710863
7RNA polymerase_Homo sapiens_hsa030202.58194087
8* RNA transport_Homo sapiens_hsa030132.46295276
9Parkinsons disease_Homo sapiens_hsa050122.00613999
10Nucleotide excision repair_Homo sapiens_hsa034202.00326809
11Oocyte meiosis_Homo sapiens_hsa041141.97360398
12Cell cycle_Homo sapiens_hsa041101.95467867
13Oxidative phosphorylation_Homo sapiens_hsa001901.91661247
14Synaptic vesicle cycle_Homo sapiens_hsa047211.89398152
15Nicotine addiction_Homo sapiens_hsa050331.83131215
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69640737
17Pyrimidine metabolism_Homo sapiens_hsa002401.67317869
18Pyruvate metabolism_Homo sapiens_hsa006201.63137954
19Huntingtons disease_Homo sapiens_hsa050161.62196738
20Long-term potentiation_Homo sapiens_hsa047201.59234991
21Base excision repair_Homo sapiens_hsa034101.57803941
22Vitamin B6 metabolism_Homo sapiens_hsa007501.52031259
23Homologous recombination_Homo sapiens_hsa034401.49235298
24mRNA surveillance pathway_Homo sapiens_hsa030151.48775986
25Alzheimers disease_Homo sapiens_hsa050101.42490294
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34177479
27Cardiac muscle contraction_Homo sapiens_hsa042601.33817995
28Dopaminergic synapse_Homo sapiens_hsa047281.32572639
29Propanoate metabolism_Homo sapiens_hsa006401.27750515
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25836011
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25266764
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24998864
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22984511
34Circadian entrainment_Homo sapiens_hsa047131.21860368
35Selenocompound metabolism_Homo sapiens_hsa004501.20174245
36RNA degradation_Homo sapiens_hsa030181.17751106
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16585236
38Basal transcription factors_Homo sapiens_hsa030221.15737203
39Amphetamine addiction_Homo sapiens_hsa050311.15415349
40Folate biosynthesis_Homo sapiens_hsa007901.15285912
41Alcoholism_Homo sapiens_hsa050341.14452118
42Olfactory transduction_Homo sapiens_hsa047401.14440955
43Glutamatergic synapse_Homo sapiens_hsa047241.11234005
44One carbon pool by folate_Homo sapiens_hsa006701.11036469
45GABAergic synapse_Homo sapiens_hsa047271.05858078
46Purine metabolism_Homo sapiens_hsa002300.99791886
47Long-term depression_Homo sapiens_hsa047300.99006871
48Steroid biosynthesis_Homo sapiens_hsa001000.96491732
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94831541
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92554964
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92267529
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88693371
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88275915
54Morphine addiction_Homo sapiens_hsa050320.88195887
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88011260
56Gap junction_Homo sapiens_hsa045400.87081830
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86652219
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86475068
59Fanconi anemia pathway_Homo sapiens_hsa034600.82997955
60Colorectal cancer_Homo sapiens_hsa052100.82463306
61Cholinergic synapse_Homo sapiens_hsa047250.81975017
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80717363
63Systemic lupus erythematosus_Homo sapiens_hsa053220.79593656
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79350677
65Epstein-Barr virus infection_Homo sapiens_hsa051690.77924349
66Fatty acid elongation_Homo sapiens_hsa000620.75600992
67Glioma_Homo sapiens_hsa052140.75076268
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74728186
69Hippo signaling pathway_Homo sapiens_hsa043900.74567421
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74360743
71Oxytocin signaling pathway_Homo sapiens_hsa049210.73540125
72p53 signaling pathway_Homo sapiens_hsa041150.73186084
73Serotonergic synapse_Homo sapiens_hsa047260.73066988
74Thyroid cancer_Homo sapiens_hsa052160.72714664
75Arginine and proline metabolism_Homo sapiens_hsa003300.69700722
76Non-homologous end-joining_Homo sapiens_hsa034500.68503678
77Melanogenesis_Homo sapiens_hsa049160.68263428
78Collecting duct acid secretion_Homo sapiens_hsa049660.67526800
79Salivary secretion_Homo sapiens_hsa049700.67244299
80Glutathione metabolism_Homo sapiens_hsa004800.67227751
81Axon guidance_Homo sapiens_hsa043600.65284849
82Gastric acid secretion_Homo sapiens_hsa049710.62996115
83GnRH signaling pathway_Homo sapiens_hsa049120.59634248
84Vibrio cholerae infection_Homo sapiens_hsa051100.58780374
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57883934
86Sulfur metabolism_Homo sapiens_hsa009200.57110012
87Hedgehog signaling pathway_Homo sapiens_hsa043400.56833409
88Wnt signaling pathway_Homo sapiens_hsa043100.56340968
89Biosynthesis of amino acids_Homo sapiens_hsa012300.54583374
90Estrogen signaling pathway_Homo sapiens_hsa049150.54458990
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.53298397
92Calcium signaling pathway_Homo sapiens_hsa040200.53266225
93Sulfur relay system_Homo sapiens_hsa041220.52994939
94Metabolic pathways_Homo sapiens_hsa011000.52886100
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52696165
96Basal cell carcinoma_Homo sapiens_hsa052170.50795075
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49968619
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.49290252
99Taste transduction_Homo sapiens_hsa047420.48703721
100Endometrial cancer_Homo sapiens_hsa052130.48071295
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48054057
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.45961118
103Melanoma_Homo sapiens_hsa052180.45712784
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45005656
105Pentose phosphate pathway_Homo sapiens_hsa000300.44716572
106Renin secretion_Homo sapiens_hsa049240.44396622
107Viral carcinogenesis_Homo sapiens_hsa052030.44356771
108mTOR signaling pathway_Homo sapiens_hsa041500.42191151
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41900600
110Phototransduction_Homo sapiens_hsa047440.40741934
111ErbB signaling pathway_Homo sapiens_hsa040120.38373632
112Tight junction_Homo sapiens_hsa045300.38187608
113TGF-beta signaling pathway_Homo sapiens_hsa043500.38097298
114HIF-1 signaling pathway_Homo sapiens_hsa040660.38051111
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38039456
116HTLV-I infection_Homo sapiens_hsa051660.35940811
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35715358
118VEGF signaling pathway_Homo sapiens_hsa043700.35624390
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.35083172
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34254025
121Bladder cancer_Homo sapiens_hsa052190.34145341
122beta-Alanine metabolism_Homo sapiens_hsa004100.33580403
123Lysine degradation_Homo sapiens_hsa003100.32787758
124Protein export_Homo sapiens_hsa030600.31983248
125Adherens junction_Homo sapiens_hsa045200.30406226
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.30338500
127Insulin secretion_Homo sapiens_hsa049110.29959956
128Arginine biosynthesis_Homo sapiens_hsa002200.29124786
129N-Glycan biosynthesis_Homo sapiens_hsa005100.28664932
130MicroRNAs in cancer_Homo sapiens_hsa052060.28333684
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28080735
132Carbon metabolism_Homo sapiens_hsa012000.27677541
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26313623
134Fatty acid metabolism_Homo sapiens_hsa012120.25823243
135Fatty acid degradation_Homo sapiens_hsa000710.24942872
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23452092
137Vitamin digestion and absorption_Homo sapiens_hsa049770.21728530
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21161905
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19847043
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17881426
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17187074
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15226151
143Tyrosine metabolism_Homo sapiens_hsa003500.13859778
144Glucagon signaling pathway_Homo sapiens_hsa049220.08463955
145Peroxisome_Homo sapiens_hsa041460.06537475
146Nitrogen metabolism_Homo sapiens_hsa009100.04562121
147Circadian rhythm_Homo sapiens_hsa047100.04546734

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »