EIF1AXP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.96199654
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.34681728
3RNA localization (GO:0006403)5.13800085
4negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.11698381
5regulation of mitochondrial translation (GO:0070129)4.77143560
6proteasome assembly (GO:0043248)4.77065438
7pseudouridine synthesis (GO:0001522)4.74126109
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38275628
9rRNA modification (GO:0000154)4.27888773
10negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.18991832
11CENP-A containing nucleosome assembly (GO:0034080)4.14797040
12protein complex biogenesis (GO:0070271)4.09938564
13regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.06965403
14chromatin remodeling at centromere (GO:0031055)4.06323952
15DNA replication-dependent nucleosome organization (GO:0034723)4.01854231
16DNA replication-dependent nucleosome assembly (GO:0006335)4.01854231
17mitochondrial respiratory chain complex assembly (GO:0033108)4.01851750
18cytochrome complex assembly (GO:0017004)3.97579424
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96258866
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96258866
21chaperone-mediated protein transport (GO:0072321)3.96068237
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.88402571
23cullin deneddylation (GO:0010388)3.80787945
24ATP synthesis coupled proton transport (GO:0015986)3.79693347
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79693347
26positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.76591914
27positive regulation of translational initiation (GO:0045948)3.74546215
28ribosome assembly (GO:0042255)3.71022156
29histone exchange (GO:0043486)3.66304918
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63465098
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56942504
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54880057
33protein deneddylation (GO:0000338)3.53509802
34protein neddylation (GO:0045116)3.52593460
35spliceosomal snRNP assembly (GO:0000387)3.51074061
36termination of RNA polymerase III transcription (GO:0006386)3.46388271
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.46388271
38respiratory chain complex IV assembly (GO:0008535)3.46132922
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44416036
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44058085
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.44058085
42NADH dehydrogenase complex assembly (GO:0010257)3.44058085
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33669904
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32646971
45DNA damage response, detection of DNA damage (GO:0042769)3.32136380
46regulation of cellular amino acid metabolic process (GO:0006521)3.26351119
47inner mitochondrial membrane organization (GO:0007007)3.25682917
48regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.24560467
49mitochondrial RNA metabolic process (GO:0000959)3.24142835
50respiratory electron transport chain (GO:0022904)3.23307193
51secretory granule organization (GO:0033363)3.20833679
52DNA replication-independent nucleosome organization (GO:0034724)3.18940844
53DNA replication-independent nucleosome assembly (GO:0006336)3.18940844
54establishment of protein localization to mitochondrion (GO:0072655)3.18668858
55electron transport chain (GO:0022900)3.18500933
56rRNA methylation (GO:0031167)3.16127283
57DNA replication checkpoint (GO:0000076)3.15361610
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14261157
59water-soluble vitamin biosynthetic process (GO:0042364)3.12756782
60pyrimidine nucleotide catabolic process (GO:0006244)3.12044950
61negative regulation of ligase activity (GO:0051352)3.11048765
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11048765
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.09109454
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09109454
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08831287
66histone H2A acetylation (GO:0043968)3.05962766
67tRNA processing (GO:0008033)3.04817896
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02533242
69protein localization to mitochondrion (GO:0070585)2.99944675
70histone mRNA metabolic process (GO:0008334)2.99354030
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99138361
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97451249
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97451249
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97451249
75protein targeting to mitochondrion (GO:0006626)2.95510601
76ribosomal large subunit biogenesis (GO:0042273)2.95283513
77rRNA processing (GO:0006364)2.94209744
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93706628
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93706628
80negative regulation of signal transduction by p53 class mediator (GO:1901797)2.92472637
81telomere maintenance via semi-conservative replication (GO:0032201)2.92280918
82ubiquinone biosynthetic process (GO:0006744)2.90807096
83rRNA metabolic process (GO:0016072)2.89908766
84DNA strand elongation involved in DNA replication (GO:0006271)2.88845675
85cellular component biogenesis (GO:0044085)2.88690360
86DNA deamination (GO:0045006)2.88674103
87transcription from mitochondrial promoter (GO:0006390)2.88033673
88viral mRNA export from host cell nucleus (GO:0046784)2.87929153
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86822825
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85907023
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.85907023
92ribosomal small subunit assembly (GO:0000028)2.85848324
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.84938455
94regulation of mitotic spindle checkpoint (GO:1903504)2.84167558
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84167558
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82676123
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82676123
98isotype switching (GO:0045190)2.82676123
99tRNA metabolic process (GO:0006399)2.82450064
100platelet dense granule organization (GO:0060155)2.82307832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.16410756
2E2F7_22180533_ChIP-Seq_HELA_Human4.31135796
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.01512680
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.96997985
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28717411
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26178646
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.17554749
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04862075
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01935747
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97150647
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.93018866
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82699910
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71850185
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66034112
15VDR_23849224_ChIP-Seq_CD4+_Human2.57560100
16ELK1_19687146_ChIP-ChIP_HELA_Human2.56169943
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53853973
18FOXP3_21729870_ChIP-Seq_TREG_Human2.38936406
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27580133
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26828520
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16919162
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10256074
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07684661
24ZNF274_21170338_ChIP-Seq_K562_Hela2.03023358
25VDR_22108803_ChIP-Seq_LS180_Human1.99150409
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99058101
27DCP1A_22483619_ChIP-Seq_HELA_Human1.95008414
28MYC_18940864_ChIP-ChIP_HL60_Human1.91514217
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91240379
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90456696
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.89797297
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85070307
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.82974052
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78552016
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77314445
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73935229
37TTF2_22483619_ChIP-Seq_HELA_Human1.72278213
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.72038159
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71906149
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71450844
41GABP_19822575_ChIP-Seq_HepG2_Human1.71105287
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68383412
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67242458
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.63662163
45EWS_26573619_Chip-Seq_HEK293_Human1.56214716
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52611505
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51006415
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50006207
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47833056
50XRN2_22483619_ChIP-Seq_HELA_Human1.44194880
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41516214
52FUS_26573619_Chip-Seq_HEK293_Human1.41306924
53IRF1_19129219_ChIP-ChIP_H3396_Human1.40683856
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.38917054
55IGF1R_20145208_ChIP-Seq_DFB_Human1.35638356
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26601959
57CIITA_25753668_ChIP-Seq_RAJI_Human1.25183444
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24316717
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24267049
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22718049
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21136075
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18610101
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18198658
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17509366
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.15319013
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12934520
67KDM5A_27292631_Chip-Seq_BREAST_Human1.08207893
68P300_19829295_ChIP-Seq_ESCs_Human1.05310034
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.04327669
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00873030
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00109439
72TAF15_26573619_Chip-Seq_HEK293_Human0.99048060
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98441990
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97856262
75SOX2_16153702_ChIP-ChIP_HESCs_Human0.96599992
76FOXM1_23109430_ChIP-Seq_U2OS_Human0.96564301
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.94811903
78TP53_22573176_ChIP-Seq_HFKS_Human0.94096121
79AR_21909140_ChIP-Seq_LNCAP_Human0.93920780
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92330135
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.91463304
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91448630
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89097073
84CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88985246
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88337797
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88141189
87AR_20517297_ChIP-Seq_VCAP_Human0.86495642
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86348043
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86175292
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84657588
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84116970
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.84116970
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83834562
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83794929
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83242383
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.79365981
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.78905142
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78717229
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78474467
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77792822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.91151168
2MP0010094_abnormal_chromosome_stability3.63371730
3MP0003693_abnormal_embryo_hatching3.61789074
4MP0006292_abnormal_olfactory_placode3.55343397
5MP0004957_abnormal_blastocyst_morpholog3.19325412
6MP0002102_abnormal_ear_morphology2.89123280
7MP0006035_abnormal_mitochondrial_morpho2.61849158
8MP0003718_maternal_effect2.44080456
9MP0006072_abnormal_retinal_apoptosis2.40741106
10MP0003111_abnormal_nucleus_morphology2.37567966
11MP0000372_irregular_coat_pigmentation2.36476185
12MP0004147_increased_porphyrin_level2.34556481
13MP0001529_abnormal_vocalization2.29508013
14MP0008877_abnormal_DNA_methylation2.29255659
15MP0005084_abnormal_gallbladder_morpholo2.12182018
16MP0005410_abnormal_fertilization2.07664024
17MP0008932_abnormal_embryonic_tissue2.07308708
18MP0003077_abnormal_cell_cycle2.06400991
19MP0006036_abnormal_mitochondrial_physio2.02845085
20MP0003646_muscle_fatigue1.95101887
21MP0009697_abnormal_copulation1.87902505
22MP0003186_abnormal_redox_activity1.87569933
23MP0003195_calcinosis1.86797233
24MP0002736_abnormal_nociception_after1.79027505
25MP0003136_yellow_coat_color1.73526998
26MP0005645_abnormal_hypothalamus_physiol1.70709513
27MP0002938_white_spotting1.67561031
28MP0008057_abnormal_DNA_replication1.54435698
29MP0005253_abnormal_eye_physiology1.53446792
30MP0003786_premature_aging1.52971473
31MP0002163_abnormal_gland_morphology1.51619123
32MP0005646_abnormal_pituitary_gland1.45809907
33MP0002837_dystrophic_cardiac_calcinosis1.45195048
34MP0001764_abnormal_homeostasis1.44129323
35MP0008872_abnormal_physiological_respon1.43178089
36MP0008789_abnormal_olfactory_epithelium1.37754237
37MP0003806_abnormal_nucleotide_metabolis1.34215663
38MP0000358_abnormal_cell_content/1.32263114
39MP0002160_abnormal_reproductive_system1.32079368
40MP0002277_abnormal_respiratory_mucosa1.29304898
41MP0003011_delayed_dark_adaptation1.28693641
42MP0008995_early_reproductive_senescence1.28155277
43MP0002234_abnormal_pharynx_morphology1.27870566
44MP0005075_abnormal_melanosome_morpholog1.26219139
45MP0002210_abnormal_sex_determination1.25927775
46MP0001968_abnormal_touch/_nociception1.24087629
47MP0001293_anophthalmia1.23828871
48MP0001929_abnormal_gametogenesis1.15720361
49MP0000631_abnormal_neuroendocrine_gland1.13807631
50MP0004133_heterotaxia1.13196310
51MP0005551_abnormal_eye_electrophysiolog1.12060132
52MP0004145_abnormal_muscle_electrophysio1.11132783
53MP0005379_endocrine/exocrine_gland_phen1.10184686
54MP0005389_reproductive_system_phenotype1.09296706
55MP0009046_muscle_twitch1.08939242
56MP0004142_abnormal_muscle_tone1.07887558
57MP0006276_abnormal_autonomic_nervous1.07016747
58MP0008007_abnormal_cellular_replicative1.01086279
59MP0008875_abnormal_xenobiotic_pharmacok1.00207655
60MP0005671_abnormal_response_to0.99709987
61MP0001145_abnormal_male_reproductive0.99607161
62MP0000653_abnormal_sex_gland0.99220484
63MP0000647_abnormal_sebaceous_gland0.99185115
64MP0003121_genomic_imprinting0.96399076
65MP0003941_abnormal_skin_development0.96377888
66MP0001919_abnormal_reproductive_system0.95298292
67MP0002751_abnormal_autonomic_nervous0.94348488
68MP0000516_abnormal_urinary_system0.93483251
69MP0005367_renal/urinary_system_phenotyp0.93483251
70MP0001119_abnormal_female_reproductive0.92198380
71MP0003787_abnormal_imprinting0.91539084
72MP0001905_abnormal_dopamine_level0.90731540
73MP0002876_abnormal_thyroid_physiology0.90322172
74MP0003698_abnormal_male_reproductive0.87240379
75MP0005636_abnormal_mineral_homeostasis0.86361855
76MP0003567_abnormal_fetal_cardiomyocyte0.85909142
77MP0001188_hyperpigmentation0.85186630
78MP0005332_abnormal_amino_acid0.83364133
79MP0002822_catalepsy0.82455140
80MP0005499_abnormal_olfactory_system0.82313931
81MP0005394_taste/olfaction_phenotype0.82313931
82MP0005187_abnormal_penis_morphology0.81113552
83MP0002095_abnormal_skin_pigmentation0.80881129
84MP0001984_abnormal_olfaction0.78414444
85MP0002138_abnormal_hepatobiliary_system0.76626074
86MP0002090_abnormal_vision0.75375212
87MP0004215_abnormal_myocardial_fiber0.74525320
88MP0001286_abnormal_eye_development0.73624121
89MP0001727_abnormal_embryo_implantation0.73483004
90MP0001661_extended_life_span0.72290727
91MP0010386_abnormal_urinary_bladder0.71867925
92MP0009745_abnormal_behavioral_response0.71229422
93MP0001730_embryonic_growth_arrest0.69527037
94MP0003315_abnormal_perineum_morphology0.69475581
95MP0001697_abnormal_embryo_size0.69161451
96MP0002148_abnormal_hypersensitivity_rea0.66295674
97MP0005391_vision/eye_phenotype0.65960613
98MP0001986_abnormal_taste_sensitivity0.65907345
99MP0003890_abnormal_embryonic-extraembry0.65359452
100MP0003880_abnormal_central_pattern0.65016707

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.51638181
2Acute encephalopathy (HP:0006846)4.09124838
3Abnormal mitochondria in muscle tissue (HP:0008316)4.03706336
4Progressive macrocephaly (HP:0004481)3.74333580
5Increased CSF lactate (HP:0002490)3.73319586
6Mitochondrial inheritance (HP:0001427)3.71458071
7Increased hepatocellular lipid droplets (HP:0006565)3.36545952
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31394811
9Abnormality of alanine metabolism (HP:0010916)3.31394811
10Hyperalaninemia (HP:0003348)3.31394811
11Hepatocellular necrosis (HP:0001404)3.22810015
12Cerebral edema (HP:0002181)3.19065618
13Lipid accumulation in hepatocytes (HP:0006561)3.14348875
143-Methylglutaconic aciduria (HP:0003535)3.13112582
15Hepatic necrosis (HP:0002605)3.01638014
16Hyperglycinemia (HP:0002154)2.99597224
17Cerebral hypomyelination (HP:0006808)2.93517858
18Methylmalonic acidemia (HP:0002912)2.86280422
19Aplastic anemia (HP:0001915)2.84731016
20Increased serum lactate (HP:0002151)2.83742722
21Lactic acidosis (HP:0003128)2.60597822
22Abnormality of serum amino acid levels (HP:0003112)2.60557529
23Oral leukoplakia (HP:0002745)2.55062602
24Pendular nystagmus (HP:0012043)2.51484128
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44526203
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44526203
27Aplasia/hypoplasia of the uterus (HP:0008684)2.40312909
28Abolished electroretinogram (ERG) (HP:0000550)2.39628919
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39314453
30Premature ovarian failure (HP:0008209)2.36193321
31Meckel diverticulum (HP:0002245)2.34575050
32Concave nail (HP:0001598)2.33701801
33Lethargy (HP:0001254)2.26696207
34Renal Fanconi syndrome (HP:0001994)2.26587414
35Abnormality of the ileum (HP:0001549)2.26034259
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.25064291
37Pancreatic cysts (HP:0001737)2.24981199
38Multiple enchondromatosis (HP:0005701)2.24021969
39Abnormality of the preputium (HP:0100587)2.22949242
40Colon cancer (HP:0003003)2.21189467
41CNS demyelination (HP:0007305)2.19494607
42Optic disc pallor (HP:0000543)2.18632876
43Leukodystrophy (HP:0002415)2.17857678
44Methylmalonic aciduria (HP:0012120)2.17587613
45Pancreatic fibrosis (HP:0100732)2.16123102
46Exercise intolerance (HP:0003546)2.15438141
47Increased intramyocellular lipid droplets (HP:0012240)2.15151870
48True hermaphroditism (HP:0010459)2.14365334
49Exertional dyspnea (HP:0002875)2.14275150
50Pancytopenia (HP:0001876)2.12362150
51Abnormality of chromosome stability (HP:0003220)2.12005853
52Type I transferrin isoform profile (HP:0003642)2.12004902
53Medial flaring of the eyebrow (HP:0010747)2.08613769
54Respiratory failure (HP:0002878)2.08288349
55Median cleft lip (HP:0000161)2.07868683
56Abnormality of the labia minora (HP:0012880)2.05316919
57Congenital, generalized hypertrichosis (HP:0004540)2.02032596
58Short tibia (HP:0005736)1.98761325
59Molar tooth sign on MRI (HP:0002419)1.98643947
60Abnormality of midbrain morphology (HP:0002418)1.98643947
61Abnormal protein glycosylation (HP:0012346)1.96138528
62Abnormal glycosylation (HP:0012345)1.96138528
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96138528
64Abnormal protein N-linked glycosylation (HP:0012347)1.96138528
65Abnormality of glycine metabolism (HP:0010895)1.95690692
66Abnormality of serine family amino acid metabolism (HP:0010894)1.95690692
67Hypoplasia of the uterus (HP:0000013)1.95586947
68Renal cortical cysts (HP:0000803)1.95062072
69Birth length less than 3rd percentile (HP:0003561)1.89550271
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87950536
71Abnormality of the anterior horn cell (HP:0006802)1.85099564
72Degeneration of anterior horn cells (HP:0002398)1.85099564
73Facial cleft (HP:0002006)1.85001944
74CNS hypomyelination (HP:0003429)1.82000885
75Hypoglycemic coma (HP:0001325)1.81698808
76Reduced antithrombin III activity (HP:0001976)1.81429845
77Duodenal stenosis (HP:0100867)1.81338567
78Small intestinal stenosis (HP:0012848)1.81338567
79Respiratory difficulties (HP:0002880)1.80799975
80Nephronophthisis (HP:0000090)1.80550323
81Hyperglycinuria (HP:0003108)1.77696117
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.77093553
83Constricted visual fields (HP:0001133)1.76142736
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74374030
85Nephrogenic diabetes insipidus (HP:0009806)1.73579906
86Delusions (HP:0000746)1.72477644
87Triphalangeal thumb (HP:0001199)1.71759272
88Abnormality of methionine metabolism (HP:0010901)1.71622912
89Microvesicular hepatic steatosis (HP:0001414)1.71175123
90Chromsome breakage (HP:0040012)1.71070909
91Hypoglycemic seizures (HP:0002173)1.70710682
92Generalized aminoaciduria (HP:0002909)1.70678215
93Ependymoma (HP:0002888)1.68915727
94Postnatal microcephaly (HP:0005484)1.68598191
95Emotional lability (HP:0000712)1.68273247
96Congenital primary aphakia (HP:0007707)1.68143131
97Testicular atrophy (HP:0000029)1.67739944
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67172954
99Cleft eyelid (HP:0000625)1.66268056
100Hypothermia (HP:0002045)1.66223162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.52641196
2MST43.06979932
3NEK12.97210835
4VRK22.93363886
5EIF2AK32.67610033
6BUB12.61357879
7CDC72.57481483
8SRPK12.43663665
9MAP4K22.26872313
10ZAK2.24712902
11EIF2AK12.15982417
12PRKCI1.99739459
13BMPR21.99290319
14VRK11.98184058
15TRIM281.97976852
16TSSK61.93219812
17PLK31.91661660
18PBK1.84414997
19BCKDK1.82507003
20WNK31.78008390
21NUAK11.72958696
22STK161.66813214
23MKNK11.56914267
24WEE11.52046574
25PLK41.49862507
26MAP2K71.48525691
27CDK191.46975674
28MAP3K121.27755300
29PLK11.25846427
30TTK1.22210957
31MAP3K41.19729807
32BCR1.15812241
33TLK11.15099306
34INSRR1.14175883
35MAPKAPK31.12463924
36MKNK21.10921780
37CSNK1G11.10733793
38CSNK1G31.09329243
39PLK21.09064423
40DAPK11.07138289
41PNCK1.06679357
42DYRK21.05140938
43OXSR11.05049298
44RPS6KA41.04947431
45PASK1.03485489
46BMPR1B1.01924499
47BRSK20.99004156
48PRKCG0.98489404
49CSNK1G20.97929143
50ADRBK20.97731922
51GRK10.96348663
52PRKCE0.94956256
53ATR0.94689105
54DAPK30.89952917
55AURKB0.89723153
56CHEK20.85755076
57ERBB30.83756078
58KDR0.81860762
59NME10.80838836
60CSNK1A1L0.78098721
61FLT30.76476748
62CLK10.73748196
63STK38L0.73543441
64MAPK130.72700617
65CSNK2A10.71811289
66AURKA0.70312402
67SCYL20.69694245
68WNK40.65830663
69CSNK2A20.64885637
70TXK0.64394339
71DYRK30.63478060
72RPS6KA50.63181829
73CCNB10.61617211
74FRK0.59350532
75EIF2AK20.59165819
76PDK20.57901732
77TEC0.56172465
78ATM0.56113217
79CHEK10.54785072
80CSNK1A10.50684931
81TNIK0.49864131
82CDK30.48560866
83NME20.47382161
84STK390.44360423
85MUSK0.44320878
86BRSK10.42166156
87TAF10.41576120
88ACVR1B0.39735402
89MAPKAPK50.39616087
90CDK70.37528705
91PIM20.37512646
92CSNK1E0.36829285
93CDK140.35218364
94RPS6KB20.35005341
95ILK0.31742830
96YES10.30693449
97MINK10.30020831
98CDK11A0.29770502
99FER0.29504382
100STK240.28970215

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15760802
2Protein export_Homo sapiens_hsa030603.58031883
3Oxidative phosphorylation_Homo sapiens_hsa001903.14092042
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10288985
5DNA replication_Homo sapiens_hsa030302.92591746
6Mismatch repair_Homo sapiens_hsa034302.85289736
7Parkinsons disease_Homo sapiens_hsa050122.71807450
8RNA polymerase_Homo sapiens_hsa030202.70182696
9Ribosome_Homo sapiens_hsa030102.58305420
10Spliceosome_Homo sapiens_hsa030402.20341901
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19235575
12RNA degradation_Homo sapiens_hsa030182.17889949
13Homologous recombination_Homo sapiens_hsa034402.15573310
14RNA transport_Homo sapiens_hsa030132.15005407
15Base excision repair_Homo sapiens_hsa034102.07919735
16Non-homologous end-joining_Homo sapiens_hsa034502.02880353
17Huntingtons disease_Homo sapiens_hsa050161.88037955
18One carbon pool by folate_Homo sapiens_hsa006701.86060480
19Nucleotide excision repair_Homo sapiens_hsa034201.69619027
20Basal transcription factors_Homo sapiens_hsa030221.68330741
21Pyrimidine metabolism_Homo sapiens_hsa002401.68040074
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66952976
23Fanconi anemia pathway_Homo sapiens_hsa034601.62402329
24Asthma_Homo sapiens_hsa053101.55858445
25Alzheimers disease_Homo sapiens_hsa050101.48207943
26Propanoate metabolism_Homo sapiens_hsa006401.38886055
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.38148441
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34770062
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31783717
30Sulfur relay system_Homo sapiens_hsa041221.30315566
31Fatty acid elongation_Homo sapiens_hsa000621.29891457
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29790736
33Regulation of autophagy_Homo sapiens_hsa041401.25531898
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25295057
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23613197
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22647054
37Purine metabolism_Homo sapiens_hsa002301.20554201
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20161088
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.16619525
40Sulfur metabolism_Homo sapiens_hsa009201.07213598
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05136523
42Cardiac muscle contraction_Homo sapiens_hsa042601.03395160
43Tyrosine metabolism_Homo sapiens_hsa003501.00607353
44Graft-versus-host disease_Homo sapiens_hsa053320.96892901
45Selenocompound metabolism_Homo sapiens_hsa004500.96038586
46Cell cycle_Homo sapiens_hsa041100.94372590
47Type I diabetes mellitus_Homo sapiens_hsa049400.88765688
48Allograft rejection_Homo sapiens_hsa053300.88707111
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87848992
50Glutathione metabolism_Homo sapiens_hsa004800.87235133
51Autoimmune thyroid disease_Homo sapiens_hsa053200.84273508
52Peroxisome_Homo sapiens_hsa041460.82734716
53mRNA surveillance pathway_Homo sapiens_hsa030150.79998190
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.78434509
55Butanoate metabolism_Homo sapiens_hsa006500.78159355
56Collecting duct acid secretion_Homo sapiens_hsa049660.77757330
57Folate biosynthesis_Homo sapiens_hsa007900.76417703
58Pyruvate metabolism_Homo sapiens_hsa006200.73453631
59Phototransduction_Homo sapiens_hsa047440.72036402
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70616983
61Steroid biosynthesis_Homo sapiens_hsa001000.70424925
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67269403
63Metabolic pathways_Homo sapiens_hsa011000.66908293
64Antigen processing and presentation_Homo sapiens_hsa046120.64408631
65Caffeine metabolism_Homo sapiens_hsa002320.62763058
66Systemic lupus erythematosus_Homo sapiens_hsa053220.61904984
67Fatty acid metabolism_Homo sapiens_hsa012120.56407025
68Tryptophan metabolism_Homo sapiens_hsa003800.55966873
69Rheumatoid arthritis_Homo sapiens_hsa053230.55317980
70Oocyte meiosis_Homo sapiens_hsa041140.54607577
71Epstein-Barr virus infection_Homo sapiens_hsa051690.51621000
72Carbon metabolism_Homo sapiens_hsa012000.49253603
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48043202
74Olfactory transduction_Homo sapiens_hsa047400.46982581
75p53 signaling pathway_Homo sapiens_hsa041150.46934590
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46763895
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46412205
78Biosynthesis of amino acids_Homo sapiens_hsa012300.45299405
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43227729
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41349469
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39859011
82beta-Alanine metabolism_Homo sapiens_hsa004100.38629886
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38557401
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36063231
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33038057
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32492444
87Retinol metabolism_Homo sapiens_hsa008300.32099994
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31477175
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31233161
90Nitrogen metabolism_Homo sapiens_hsa009100.29433407
91Linoleic acid metabolism_Homo sapiens_hsa005910.28766702
92Chemical carcinogenesis_Homo sapiens_hsa052040.28082621
93Primary immunodeficiency_Homo sapiens_hsa053400.27735847
94Fatty acid degradation_Homo sapiens_hsa000710.27107407
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26681359
96Taste transduction_Homo sapiens_hsa047420.26573002
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25460806
98Pentose phosphate pathway_Homo sapiens_hsa000300.21742134
99TGF-beta signaling pathway_Homo sapiens_hsa043500.20262689
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19783089

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