

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | maturation of 5.8S rRNA (GO:0000460) | 5.96199654 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.34681728 |
| 3 | RNA localization (GO:0006403) | 5.13800085 |
| 4 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 5.11698381 |
| 5 | regulation of mitochondrial translation (GO:0070129) | 4.77143560 |
| 6 | proteasome assembly (GO:0043248) | 4.77065438 |
| 7 | pseudouridine synthesis (GO:0001522) | 4.74126109 |
| 8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.38275628 |
| 9 | rRNA modification (GO:0000154) | 4.27888773 |
| 10 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 4.18991832 |
| 11 | CENP-A containing nucleosome assembly (GO:0034080) | 4.14797040 |
| 12 | protein complex biogenesis (GO:0070271) | 4.09938564 |
| 13 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 4.06965403 |
| 14 | chromatin remodeling at centromere (GO:0031055) | 4.06323952 |
| 15 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.01854231 |
| 16 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.01854231 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.01851750 |
| 18 | cytochrome complex assembly (GO:0017004) | 3.97579424 |
| 19 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.96258866 |
| 20 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.96258866 |
| 21 | chaperone-mediated protein transport (GO:0072321) | 3.96068237 |
| 22 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.88402571 |
| 23 | cullin deneddylation (GO:0010388) | 3.80787945 |
| 24 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.79693347 |
| 25 | ATP synthesis coupled proton transport (GO:0015986) | 3.79693347 |
| 26 | positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517) | 3.76591914 |
| 27 | positive regulation of translational initiation (GO:0045948) | 3.74546215 |
| 28 | ribosome assembly (GO:0042255) | 3.71022156 |
| 29 | histone exchange (GO:0043486) | 3.66304918 |
| 30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.63465098 |
| 31 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.56942504 |
| 32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.54880057 |
| 33 | protein deneddylation (GO:0000338) | 3.53509802 |
| 34 | protein neddylation (GO:0045116) | 3.52593460 |
| 35 | spliceosomal snRNP assembly (GO:0000387) | 3.51074061 |
| 36 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.46388271 |
| 37 | termination of RNA polymerase III transcription (GO:0006386) | 3.46388271 |
| 38 | respiratory chain complex IV assembly (GO:0008535) | 3.46132922 |
| 39 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.44416036 |
| 40 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.44058085 |
| 41 | NADH dehydrogenase complex assembly (GO:0010257) | 3.44058085 |
| 42 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.44058085 |
| 43 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.33669904 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.32646971 |
| 45 | DNA damage response, detection of DNA damage (GO:0042769) | 3.32136380 |
| 46 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.26351119 |
| 47 | inner mitochondrial membrane organization (GO:0007007) | 3.25682917 |
| 48 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 3.24560467 |
| 49 | mitochondrial RNA metabolic process (GO:0000959) | 3.24142835 |
| 50 | respiratory electron transport chain (GO:0022904) | 3.23307193 |
| 51 | secretory granule organization (GO:0033363) | 3.20833679 |
| 52 | DNA replication-independent nucleosome organization (GO:0034724) | 3.18940844 |
| 53 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.18940844 |
| 54 | establishment of protein localization to mitochondrion (GO:0072655) | 3.18668858 |
| 55 | electron transport chain (GO:0022900) | 3.18500933 |
| 56 | rRNA methylation (GO:0031167) | 3.16127283 |
| 57 | DNA replication checkpoint (GO:0000076) | 3.15361610 |
| 58 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.14261157 |
| 59 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.12756782 |
| 60 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.12044950 |
| 61 | negative regulation of ligase activity (GO:0051352) | 3.11048765 |
| 62 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.11048765 |
| 63 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.09109454 |
| 64 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.09109454 |
| 65 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.08831287 |
| 66 | histone H2A acetylation (GO:0043968) | 3.05962766 |
| 67 | tRNA processing (GO:0008033) | 3.04817896 |
| 68 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.02533242 |
| 69 | protein localization to mitochondrion (GO:0070585) | 2.99944675 |
| 70 | histone mRNA metabolic process (GO:0008334) | 2.99354030 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.99138361 |
| 72 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.97451249 |
| 73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.97451249 |
| 74 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.97451249 |
| 75 | protein targeting to mitochondrion (GO:0006626) | 2.95510601 |
| 76 | ribosomal large subunit biogenesis (GO:0042273) | 2.95283513 |
| 77 | rRNA processing (GO:0006364) | 2.94209744 |
| 78 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.93706628 |
| 79 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.93706628 |
| 80 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 2.92472637 |
| 81 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.92280918 |
| 82 | ubiquinone biosynthetic process (GO:0006744) | 2.90807096 |
| 83 | rRNA metabolic process (GO:0016072) | 2.89908766 |
| 84 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.88845675 |
| 85 | cellular component biogenesis (GO:0044085) | 2.88690360 |
| 86 | DNA deamination (GO:0045006) | 2.88674103 |
| 87 | transcription from mitochondrial promoter (GO:0006390) | 2.88033673 |
| 88 | viral mRNA export from host cell nucleus (GO:0046784) | 2.87929153 |
| 89 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.86822825 |
| 90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.85907023 |
| 91 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.85907023 |
| 92 | ribosomal small subunit assembly (GO:0000028) | 2.85848324 |
| 93 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.84938455 |
| 94 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.84167558 |
| 95 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.84167558 |
| 96 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.82676123 |
| 97 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.82676123 |
| 98 | isotype switching (GO:0045190) | 2.82676123 |
| 99 | tRNA metabolic process (GO:0006399) | 2.82450064 |
| 100 | platelet dense granule organization (GO:0060155) | 2.82307832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.16410756 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.31135796 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.01512680 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.96997985 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.28717411 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.26178646 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.17554749 |
| 8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.04862075 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01935747 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.97150647 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.93018866 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82699910 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.71850185 |
| 14 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.66034112 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.57560100 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.56169943 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.53853973 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.38936406 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.27580133 |
| 20 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.26828520 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.16919162 |
| 22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.10256074 |
| 23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.07684661 |
| 24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.03023358 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.99150409 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.99058101 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95008414 |
| 28 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.91514217 |
| 29 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.91240379 |
| 30 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.90456696 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.89797297 |
| 32 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.85070307 |
| 33 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.82974052 |
| 34 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.78552016 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.77314445 |
| 36 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.73935229 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.72278213 |
| 38 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.72038159 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71906149 |
| 40 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.71450844 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.71105287 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.68383412 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67242458 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.63662163 |
| 45 | EWS_26573619_Chip-Seq_HEK293_Human | 1.56214716 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.52611505 |
| 47 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.51006415 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.50006207 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47833056 |
| 50 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.44194880 |
| 51 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41516214 |
| 52 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41306924 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.40683856 |
| 54 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38917054 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.35638356 |
| 56 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.26601959 |
| 57 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25183444 |
| 58 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.24316717 |
| 59 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.24267049 |
| 60 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.22718049 |
| 61 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.21136075 |
| 62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.18610101 |
| 63 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.18198658 |
| 64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.17509366 |
| 65 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.15319013 |
| 66 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.12934520 |
| 67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.08207893 |
| 68 | P300_19829295_ChIP-Seq_ESCs_Human | 1.05310034 |
| 69 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.04327669 |
| 70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00873030 |
| 71 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00109439 |
| 72 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.99048060 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98441990 |
| 74 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.97856262 |
| 75 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96599992 |
| 76 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.96564301 |
| 77 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.94811903 |
| 78 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.94096121 |
| 79 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.93920780 |
| 80 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.92330135 |
| 81 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.91463304 |
| 82 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.91448630 |
| 83 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.89097073 |
| 84 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.88985246 |
| 85 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.88337797 |
| 86 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.88141189 |
| 87 | AR_20517297_ChIP-Seq_VCAP_Human | 0.86495642 |
| 88 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.86348043 |
| 89 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.86175292 |
| 90 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.84657588 |
| 91 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.84116970 |
| 92 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.84116970 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.83834562 |
| 94 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.83794929 |
| 95 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.83242383 |
| 96 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.79365981 |
| 97 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.78905142 |
| 98 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.78717229 |
| 99 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78474467 |
| 100 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.77792822 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.91151168 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.63371730 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.61789074 |
| 4 | MP0006292_abnormal_olfactory_placode | 3.55343397 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.19325412 |
| 6 | MP0002102_abnormal_ear_morphology | 2.89123280 |
| 7 | MP0006035_abnormal_mitochondrial_morpho | 2.61849158 |
| 8 | MP0003718_maternal_effect | 2.44080456 |
| 9 | MP0006072_abnormal_retinal_apoptosis | 2.40741106 |
| 10 | MP0003111_abnormal_nucleus_morphology | 2.37567966 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.36476185 |
| 12 | MP0004147_increased_porphyrin_level | 2.34556481 |
| 13 | MP0001529_abnormal_vocalization | 2.29508013 |
| 14 | MP0008877_abnormal_DNA_methylation | 2.29255659 |
| 15 | MP0005084_abnormal_gallbladder_morpholo | 2.12182018 |
| 16 | MP0005410_abnormal_fertilization | 2.07664024 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.07308708 |
| 18 | MP0003077_abnormal_cell_cycle | 2.06400991 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 2.02845085 |
| 20 | MP0003646_muscle_fatigue | 1.95101887 |
| 21 | MP0009697_abnormal_copulation | 1.87902505 |
| 22 | MP0003186_abnormal_redox_activity | 1.87569933 |
| 23 | MP0003195_calcinosis | 1.86797233 |
| 24 | MP0002736_abnormal_nociception_after | 1.79027505 |
| 25 | MP0003136_yellow_coat_color | 1.73526998 |
| 26 | MP0005645_abnormal_hypothalamus_physiol | 1.70709513 |
| 27 | MP0002938_white_spotting | 1.67561031 |
| 28 | MP0008057_abnormal_DNA_replication | 1.54435698 |
| 29 | MP0005253_abnormal_eye_physiology | 1.53446792 |
| 30 | MP0003786_premature_aging | 1.52971473 |
| 31 | MP0002163_abnormal_gland_morphology | 1.51619123 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.45809907 |
| 33 | MP0002837_dystrophic_cardiac_calcinosis | 1.45195048 |
| 34 | MP0001764_abnormal_homeostasis | 1.44129323 |
| 35 | MP0008872_abnormal_physiological_respon | 1.43178089 |
| 36 | MP0008789_abnormal_olfactory_epithelium | 1.37754237 |
| 37 | MP0003806_abnormal_nucleotide_metabolis | 1.34215663 |
| 38 | MP0000358_abnormal_cell_content/ | 1.32263114 |
| 39 | MP0002160_abnormal_reproductive_system | 1.32079368 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.29304898 |
| 41 | MP0003011_delayed_dark_adaptation | 1.28693641 |
| 42 | MP0008995_early_reproductive_senescence | 1.28155277 |
| 43 | MP0002234_abnormal_pharynx_morphology | 1.27870566 |
| 44 | MP0005075_abnormal_melanosome_morpholog | 1.26219139 |
| 45 | MP0002210_abnormal_sex_determination | 1.25927775 |
| 46 | MP0001968_abnormal_touch/_nociception | 1.24087629 |
| 47 | MP0001293_anophthalmia | 1.23828871 |
| 48 | MP0001929_abnormal_gametogenesis | 1.15720361 |
| 49 | MP0000631_abnormal_neuroendocrine_gland | 1.13807631 |
| 50 | MP0004133_heterotaxia | 1.13196310 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.12060132 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.11132783 |
| 53 | MP0005379_endocrine/exocrine_gland_phen | 1.10184686 |
| 54 | MP0005389_reproductive_system_phenotype | 1.09296706 |
| 55 | MP0009046_muscle_twitch | 1.08939242 |
| 56 | MP0004142_abnormal_muscle_tone | 1.07887558 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.07016747 |
| 58 | MP0008007_abnormal_cellular_replicative | 1.01086279 |
| 59 | MP0008875_abnormal_xenobiotic_pharmacok | 1.00207655 |
| 60 | MP0005671_abnormal_response_to | 0.99709987 |
| 61 | MP0001145_abnormal_male_reproductive | 0.99607161 |
| 62 | MP0000653_abnormal_sex_gland | 0.99220484 |
| 63 | MP0000647_abnormal_sebaceous_gland | 0.99185115 |
| 64 | MP0003121_genomic_imprinting | 0.96399076 |
| 65 | MP0003941_abnormal_skin_development | 0.96377888 |
| 66 | MP0001919_abnormal_reproductive_system | 0.95298292 |
| 67 | MP0002751_abnormal_autonomic_nervous | 0.94348488 |
| 68 | MP0005367_renal/urinary_system_phenotyp | 0.93483251 |
| 69 | MP0000516_abnormal_urinary_system | 0.93483251 |
| 70 | MP0001119_abnormal_female_reproductive | 0.92198380 |
| 71 | MP0003787_abnormal_imprinting | 0.91539084 |
| 72 | MP0001905_abnormal_dopamine_level | 0.90731540 |
| 73 | MP0002876_abnormal_thyroid_physiology | 0.90322172 |
| 74 | MP0003698_abnormal_male_reproductive | 0.87240379 |
| 75 | MP0005636_abnormal_mineral_homeostasis | 0.86361855 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.85909142 |
| 77 | MP0001188_hyperpigmentation | 0.85186630 |
| 78 | MP0005332_abnormal_amino_acid | 0.83364133 |
| 79 | MP0002822_catalepsy | 0.82455140 |
| 80 | MP0005394_taste/olfaction_phenotype | 0.82313931 |
| 81 | MP0005499_abnormal_olfactory_system | 0.82313931 |
| 82 | MP0005187_abnormal_penis_morphology | 0.81113552 |
| 83 | MP0002095_abnormal_skin_pigmentation | 0.80881129 |
| 84 | MP0001984_abnormal_olfaction | 0.78414444 |
| 85 | MP0002138_abnormal_hepatobiliary_system | 0.76626074 |
| 86 | MP0002090_abnormal_vision | 0.75375212 |
| 87 | MP0004215_abnormal_myocardial_fiber | 0.74525320 |
| 88 | MP0001286_abnormal_eye_development | 0.73624121 |
| 89 | MP0001727_abnormal_embryo_implantation | 0.73483004 |
| 90 | MP0001661_extended_life_span | 0.72290727 |
| 91 | MP0010386_abnormal_urinary_bladder | 0.71867925 |
| 92 | MP0009745_abnormal_behavioral_response | 0.71229422 |
| 93 | MP0001730_embryonic_growth_arrest | 0.69527037 |
| 94 | MP0003315_abnormal_perineum_morphology | 0.69475581 |
| 95 | MP0001697_abnormal_embryo_size | 0.69161451 |
| 96 | MP0002148_abnormal_hypersensitivity_rea | 0.66295674 |
| 97 | MP0005391_vision/eye_phenotype | 0.65960613 |
| 98 | MP0001986_abnormal_taste_sensitivity | 0.65907345 |
| 99 | MP0003890_abnormal_embryonic-extraembry | 0.65359452 |
| 100 | MP0003880_abnormal_central_pattern | 0.65016707 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.51638181 |
| 2 | Acute encephalopathy (HP:0006846) | 4.09124838 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.03706336 |
| 4 | Progressive macrocephaly (HP:0004481) | 3.74333580 |
| 5 | Increased CSF lactate (HP:0002490) | 3.73319586 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.71458071 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.36545952 |
| 8 | Abnormality of alanine metabolism (HP:0010916) | 3.31394811 |
| 9 | Hyperalaninemia (HP:0003348) | 3.31394811 |
| 10 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.31394811 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.22810015 |
| 12 | Cerebral edema (HP:0002181) | 3.19065618 |
| 13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.14348875 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.13112582 |
| 15 | Hepatic necrosis (HP:0002605) | 3.01638014 |
| 16 | Hyperglycinemia (HP:0002154) | 2.99597224 |
| 17 | Cerebral hypomyelination (HP:0006808) | 2.93517858 |
| 18 | Methylmalonic acidemia (HP:0002912) | 2.86280422 |
| 19 | Aplastic anemia (HP:0001915) | 2.84731016 |
| 20 | Increased serum lactate (HP:0002151) | 2.83742722 |
| 21 | Lactic acidosis (HP:0003128) | 2.60597822 |
| 22 | Abnormality of serum amino acid levels (HP:0003112) | 2.60557529 |
| 23 | Oral leukoplakia (HP:0002745) | 2.55062602 |
| 24 | Pendular nystagmus (HP:0012043) | 2.51484128 |
| 25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.44526203 |
| 26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.44526203 |
| 27 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.40312909 |
| 28 | Abolished electroretinogram (ERG) (HP:0000550) | 2.39628919 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.39314453 |
| 30 | Premature ovarian failure (HP:0008209) | 2.36193321 |
| 31 | Meckel diverticulum (HP:0002245) | 2.34575050 |
| 32 | Concave nail (HP:0001598) | 2.33701801 |
| 33 | Lethargy (HP:0001254) | 2.26696207 |
| 34 | Renal Fanconi syndrome (HP:0001994) | 2.26587414 |
| 35 | Abnormality of the ileum (HP:0001549) | 2.26034259 |
| 36 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.25064291 |
| 37 | Pancreatic cysts (HP:0001737) | 2.24981199 |
| 38 | Multiple enchondromatosis (HP:0005701) | 2.24021969 |
| 39 | Abnormality of the preputium (HP:0100587) | 2.22949242 |
| 40 | Colon cancer (HP:0003003) | 2.21189467 |
| 41 | CNS demyelination (HP:0007305) | 2.19494607 |
| 42 | Optic disc pallor (HP:0000543) | 2.18632876 |
| 43 | Leukodystrophy (HP:0002415) | 2.17857678 |
| 44 | Methylmalonic aciduria (HP:0012120) | 2.17587613 |
| 45 | Pancreatic fibrosis (HP:0100732) | 2.16123102 |
| 46 | Exercise intolerance (HP:0003546) | 2.15438141 |
| 47 | Increased intramyocellular lipid droplets (HP:0012240) | 2.15151870 |
| 48 | True hermaphroditism (HP:0010459) | 2.14365334 |
| 49 | Exertional dyspnea (HP:0002875) | 2.14275150 |
| 50 | Pancytopenia (HP:0001876) | 2.12362150 |
| 51 | Abnormality of chromosome stability (HP:0003220) | 2.12005853 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.12004902 |
| 53 | Medial flaring of the eyebrow (HP:0010747) | 2.08613769 |
| 54 | Respiratory failure (HP:0002878) | 2.08288349 |
| 55 | Median cleft lip (HP:0000161) | 2.07868683 |
| 56 | Abnormality of the labia minora (HP:0012880) | 2.05316919 |
| 57 | Congenital, generalized hypertrichosis (HP:0004540) | 2.02032596 |
| 58 | Short tibia (HP:0005736) | 1.98761325 |
| 59 | Abnormality of midbrain morphology (HP:0002418) | 1.98643947 |
| 60 | Molar tooth sign on MRI (HP:0002419) | 1.98643947 |
| 61 | Abnormal protein glycosylation (HP:0012346) | 1.96138528 |
| 62 | Abnormal glycosylation (HP:0012345) | 1.96138528 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.96138528 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.96138528 |
| 65 | Abnormality of glycine metabolism (HP:0010895) | 1.95690692 |
| 66 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.95690692 |
| 67 | Hypoplasia of the uterus (HP:0000013) | 1.95586947 |
| 68 | Renal cortical cysts (HP:0000803) | 1.95062072 |
| 69 | Birth length less than 3rd percentile (HP:0003561) | 1.89550271 |
| 70 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.87950536 |
| 71 | Degeneration of anterior horn cells (HP:0002398) | 1.85099564 |
| 72 | Abnormality of the anterior horn cell (HP:0006802) | 1.85099564 |
| 73 | Facial cleft (HP:0002006) | 1.85001944 |
| 74 | CNS hypomyelination (HP:0003429) | 1.82000885 |
| 75 | Hypoglycemic coma (HP:0001325) | 1.81698808 |
| 76 | Reduced antithrombin III activity (HP:0001976) | 1.81429845 |
| 77 | Duodenal stenosis (HP:0100867) | 1.81338567 |
| 78 | Small intestinal stenosis (HP:0012848) | 1.81338567 |
| 79 | Respiratory difficulties (HP:0002880) | 1.80799975 |
| 80 | Nephronophthisis (HP:0000090) | 1.80550323 |
| 81 | Hyperglycinuria (HP:0003108) | 1.77696117 |
| 82 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.77093553 |
| 83 | Constricted visual fields (HP:0001133) | 1.76142736 |
| 84 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.74374030 |
| 85 | Nephrogenic diabetes insipidus (HP:0009806) | 1.73579906 |
| 86 | Delusions (HP:0000746) | 1.72477644 |
| 87 | Triphalangeal thumb (HP:0001199) | 1.71759272 |
| 88 | Abnormality of methionine metabolism (HP:0010901) | 1.71622912 |
| 89 | Microvesicular hepatic steatosis (HP:0001414) | 1.71175123 |
| 90 | Chromsome breakage (HP:0040012) | 1.71070909 |
| 91 | Hypoglycemic seizures (HP:0002173) | 1.70710682 |
| 92 | Generalized aminoaciduria (HP:0002909) | 1.70678215 |
| 93 | Ependymoma (HP:0002888) | 1.68915727 |
| 94 | Postnatal microcephaly (HP:0005484) | 1.68598191 |
| 95 | Emotional lability (HP:0000712) | 1.68273247 |
| 96 | Congenital primary aphakia (HP:0007707) | 1.68143131 |
| 97 | Testicular atrophy (HP:0000029) | 1.67739944 |
| 98 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.67172954 |
| 99 | Cleft eyelid (HP:0000625) | 1.66268056 |
| 100 | Hypothermia (HP:0002045) | 1.66223162 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK1 | 3.52641196 |
| 2 | MST4 | 3.06979932 |
| 3 | NEK1 | 2.97210835 |
| 4 | VRK2 | 2.93363886 |
| 5 | EIF2AK3 | 2.67610033 |
| 6 | BUB1 | 2.61357879 |
| 7 | CDC7 | 2.57481483 |
| 8 | SRPK1 | 2.43663665 |
| 9 | MAP4K2 | 2.26872313 |
| 10 | ZAK | 2.24712902 |
| 11 | EIF2AK1 | 2.15982417 |
| 12 | PRKCI | 1.99739459 |
| 13 | BMPR2 | 1.99290319 |
| 14 | VRK1 | 1.98184058 |
| 15 | TRIM28 | 1.97976852 |
| 16 | TSSK6 | 1.93219812 |
| 17 | PLK3 | 1.91661660 |
| 18 | PBK | 1.84414997 |
| 19 | BCKDK | 1.82507003 |
| 20 | WNK3 | 1.78008390 |
| 21 | NUAK1 | 1.72958696 |
| 22 | STK16 | 1.66813214 |
| 23 | MKNK1 | 1.56914267 |
| 24 | WEE1 | 1.52046574 |
| 25 | PLK4 | 1.49862507 |
| 26 | MAP2K7 | 1.48525691 |
| 27 | CDK19 | 1.46975674 |
| 28 | MAP3K12 | 1.27755300 |
| 29 | PLK1 | 1.25846427 |
| 30 | TTK | 1.22210957 |
| 31 | MAP3K4 | 1.19729807 |
| 32 | BCR | 1.15812241 |
| 33 | TLK1 | 1.15099306 |
| 34 | INSRR | 1.14175883 |
| 35 | MAPKAPK3 | 1.12463924 |
| 36 | MKNK2 | 1.10921780 |
| 37 | CSNK1G1 | 1.10733793 |
| 38 | CSNK1G3 | 1.09329243 |
| 39 | PLK2 | 1.09064423 |
| 40 | DAPK1 | 1.07138289 |
| 41 | PNCK | 1.06679357 |
| 42 | DYRK2 | 1.05140938 |
| 43 | OXSR1 | 1.05049298 |
| 44 | RPS6KA4 | 1.04947431 |
| 45 | PASK | 1.03485489 |
| 46 | BMPR1B | 1.01924499 |
| 47 | BRSK2 | 0.99004156 |
| 48 | PRKCG | 0.98489404 |
| 49 | CSNK1G2 | 0.97929143 |
| 50 | ADRBK2 | 0.97731922 |
| 51 | GRK1 | 0.96348663 |
| 52 | PRKCE | 0.94956256 |
| 53 | ATR | 0.94689105 |
| 54 | DAPK3 | 0.89952917 |
| 55 | AURKB | 0.89723153 |
| 56 | CHEK2 | 0.85755076 |
| 57 | ERBB3 | 0.83756078 |
| 58 | KDR | 0.81860762 |
| 59 | NME1 | 0.80838836 |
| 60 | CSNK1A1L | 0.78098721 |
| 61 | FLT3 | 0.76476748 |
| 62 | CLK1 | 0.73748196 |
| 63 | STK38L | 0.73543441 |
| 64 | MAPK13 | 0.72700617 |
| 65 | CSNK2A1 | 0.71811289 |
| 66 | AURKA | 0.70312402 |
| 67 | SCYL2 | 0.69694245 |
| 68 | WNK4 | 0.65830663 |
| 69 | CSNK2A2 | 0.64885637 |
| 70 | TXK | 0.64394339 |
| 71 | DYRK3 | 0.63478060 |
| 72 | RPS6KA5 | 0.63181829 |
| 73 | CCNB1 | 0.61617211 |
| 74 | FRK | 0.59350532 |
| 75 | EIF2AK2 | 0.59165819 |
| 76 | PDK2 | 0.57901732 |
| 77 | TEC | 0.56172465 |
| 78 | ATM | 0.56113217 |
| 79 | CHEK1 | 0.54785072 |
| 80 | CSNK1A1 | 0.50684931 |
| 81 | TNIK | 0.49864131 |
| 82 | CDK3 | 0.48560866 |
| 83 | NME2 | 0.47382161 |
| 84 | STK39 | 0.44360423 |
| 85 | MUSK | 0.44320878 |
| 86 | BRSK1 | 0.42166156 |
| 87 | TAF1 | 0.41576120 |
| 88 | ACVR1B | 0.39735402 |
| 89 | MAPKAPK5 | 0.39616087 |
| 90 | CDK7 | 0.37528705 |
| 91 | PIM2 | 0.37512646 |
| 92 | CSNK1E | 0.36829285 |
| 93 | CDK14 | 0.35218364 |
| 94 | RPS6KB2 | 0.35005341 |
| 95 | ILK | 0.31742830 |
| 96 | YES1 | 0.30693449 |
| 97 | MINK1 | 0.30020831 |
| 98 | CDK11A | 0.29770502 |
| 99 | FER | 0.29504382 |
| 100 | STK24 | 0.28970215 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.15760802 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.58031883 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.14092042 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.10288985 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.92591746 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.85289736 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.71807450 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.70182696 |
| 9 | Ribosome_Homo sapiens_hsa03010 | 2.58305420 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.20341901 |
| 11 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.19235575 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 2.17889949 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.15573310 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.15005407 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.07919735 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.02880353 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.88037955 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.86060480 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.69619027 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.68330741 |
| 21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.68040074 |
| 22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.66952976 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.62402329 |
| 24 | Asthma_Homo sapiens_hsa05310 | 1.55858445 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.48207943 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.38886055 |
| 27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.38148441 |
| 28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.34770062 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.31783717 |
| 30 | Sulfur relay system_Homo sapiens_hsa04122 | 1.30315566 |
| 31 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.29891457 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29790736 |
| 33 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.25531898 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.25295057 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.23613197 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.22647054 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.20554201 |
| 38 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.20161088 |
| 39 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.16619525 |
| 40 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.07213598 |
| 41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.05136523 |
| 42 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.03395160 |
| 43 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.00607353 |
| 44 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.96892901 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.96038586 |
| 46 | Cell cycle_Homo sapiens_hsa04110 | 0.94372590 |
| 47 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.88765688 |
| 48 | Allograft rejection_Homo sapiens_hsa05330 | 0.88707111 |
| 49 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.87848992 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.87235133 |
| 51 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.84273508 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.82734716 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.79998190 |
| 54 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.78434509 |
| 55 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.78159355 |
| 56 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.77757330 |
| 57 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.76417703 |
| 58 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.73453631 |
| 59 | Phototransduction_Homo sapiens_hsa04744 | 0.72036402 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70616983 |
| 61 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.70424925 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67269403 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66908293 |
| 64 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.64408631 |
| 65 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.62763058 |
| 66 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.61904984 |
| 67 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.56407025 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55966873 |
| 69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.55317980 |
| 70 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.54607577 |
| 71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.51621000 |
| 72 | Carbon metabolism_Homo sapiens_hsa01200 | 0.49253603 |
| 73 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48043202 |
| 74 | Olfactory transduction_Homo sapiens_hsa04740 | 0.46982581 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.46934590 |
| 76 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.46763895 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46412205 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45299405 |
| 79 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.43227729 |
| 80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41349469 |
| 81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.39859011 |
| 82 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38629886 |
| 83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38557401 |
| 84 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36063231 |
| 85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.33038057 |
| 86 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32492444 |
| 87 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32099994 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.31477175 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31233161 |
| 90 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.29433407 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.28766702 |
| 92 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28082621 |
| 93 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.27735847 |
| 94 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27107407 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26681359 |
| 96 | Taste transduction_Homo sapiens_hsa04742 | 0.26573002 |
| 97 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.25460806 |
| 98 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.21742134 |
| 99 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20262689 |
| 100 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.19783089 |

