EIF1AY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36567110
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.43037580
3ATP synthesis coupled proton transport (GO:0015986)5.43037580
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.93064731
5respiratory electron transport chain (GO:0022904)4.74379796
6electron transport chain (GO:0022900)4.67614845
7DNA deamination (GO:0045006)4.56339473
8protein complex biogenesis (GO:0070271)4.31272144
9cytochrome complex assembly (GO:0017004)3.98631312
10protein neddylation (GO:0045116)3.97168488
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.94250431
12cytidine metabolic process (GO:0046087)3.91515014
13cytidine catabolic process (GO:0006216)3.91515014
14cytidine deamination (GO:0009972)3.91515014
15proteasome assembly (GO:0043248)3.89891185
16mitochondrial respiratory chain complex assembly (GO:0033108)3.89017357
17respiratory chain complex IV assembly (GO:0008535)3.86868006
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.57608451
19NADH dehydrogenase complex assembly (GO:0010257)3.57608451
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57608451
21chaperone-mediated protein transport (GO:0072321)3.53074781
22DNA double-strand break processing (GO:0000729)3.43513979
23hydrogen ion transmembrane transport (GO:1902600)3.35915471
24pyrimidine ribonucleoside catabolic process (GO:0046133)3.35697639
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29756812
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29119121
27platelet dense granule organization (GO:0060155)3.17509571
28protein-cofactor linkage (GO:0018065)3.17126084
29proton transport (GO:0015992)3.16586592
30hydrogen transport (GO:0006818)3.10800070
31ATP biosynthetic process (GO:0006754)3.02915597
32ribosomal small subunit assembly (GO:0000028)2.99021509
33water-soluble vitamin biosynthetic process (GO:0042364)2.97414550
34regulation of mitochondrial translation (GO:0070129)2.97042518
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95748459
36DNA catabolic process, exonucleolytic (GO:0000738)2.92859583
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91550578
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91550578
39rRNA modification (GO:0000154)2.86840417
40termination of RNA polymerase III transcription (GO:0006386)2.85704346
41transcription elongation from RNA polymerase III promoter (GO:0006385)2.85704346
42dopamine transport (GO:0015872)2.84145126
43purine-containing compound salvage (GO:0043101)2.83762251
44adenosine metabolic process (GO:0046085)2.81299642
45regulation of regulatory T cell differentiation (GO:0045589)2.79132737
46response to interferon-beta (GO:0035456)2.77495401
47B cell mediated immunity (GO:0019724)2.72373638
48DNA demethylation (GO:0080111)2.71849242
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68285901
50behavioral response to nicotine (GO:0035095)2.64853193
51oxidative phosphorylation (GO:0006119)2.64825979
52purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64128166
53response to pheromone (GO:0019236)2.63847482
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.63828654
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63178649
56negative regulation of mast cell activation (GO:0033004)2.62790848
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62417692
58regulation of meiosis I (GO:0060631)2.60355098
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59470378
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59470378
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59470378
62negative regulation of B cell apoptotic process (GO:0002903)2.57255537
63sequestering of actin monomers (GO:0042989)2.55614641
64protein targeting to ER (GO:0045047)2.55272526
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54702227
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54702227
67translational termination (GO:0006415)2.53793557
68immunoglobulin mediated immune response (GO:0016064)2.52323881
69purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.51565190
70cotranslational protein targeting to membrane (GO:0006613)2.51245449
71negative regulation of telomere maintenance (GO:0032205)2.51061978
72inner mitochondrial membrane organization (GO:0007007)2.50961355
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50333628
74viral transcription (GO:0019083)2.50075371
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49959483
76negative regulation of heart rate (GO:0010459)2.47788157
77rRNA methylation (GO:0031167)2.47422195
78deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.45956312
79regulation of cellular amino acid metabolic process (GO:0006521)2.44974193
80establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44702008
81regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.43084177
82pseudouridine synthesis (GO:0001522)2.42506107
83spliceosomal complex assembly (GO:0000245)2.42232825
84protein localization to endoplasmic reticulum (GO:0070972)2.41522318
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.39654155
86regulation of B cell apoptotic process (GO:0002902)2.39545142
87regulation of mitotic spindle checkpoint (GO:1903504)2.38303822
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38303822
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.37256342
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.37256342
91intracellular protein transmembrane import (GO:0044743)2.35505933
92negative regulation of ligase activity (GO:0051352)2.34537015
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.34537015
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.34487567
95regulation of oxidative phosphorylation (GO:0002082)2.34193406
96chromatin remodeling at centromere (GO:0031055)2.33814356
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32933922
98mast cell activation (GO:0045576)2.32893454
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28418600
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.28398432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50106041
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.49428610
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.45603416
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99778823
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95003326
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.70734791
7ZNF274_21170338_ChIP-Seq_K562_Hela2.59581183
8VDR_22108803_ChIP-Seq_LS180_Human2.57564570
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56326491
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55253182
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.55009073
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44461119
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.41578734
14ELK1_19687146_ChIP-ChIP_HELA_Human2.29654625
15VDR_23849224_ChIP-Seq_CD4+_Human2.24712211
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15709073
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12616834
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04160051
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.04047018
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95346648
21EWS_26573619_Chip-Seq_HEK293_Human1.91076292
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90563565
23TAF15_26573619_Chip-Seq_HEK293_Human1.86733413
24IGF1R_20145208_ChIP-Seq_DFB_Human1.86285434
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84138442
26FOXP3_21729870_ChIP-Seq_TREG_Human1.75596485
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73743787
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73663179
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73368728
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.72767524
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69198802
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.68577747
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68076947
34P300_19829295_ChIP-Seq_ESCs_Human1.61345366
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.54818106
36FUS_26573619_Chip-Seq_HEK293_Human1.53849731
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53229834
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52678119
39MYC_18940864_ChIP-ChIP_HL60_Human1.50135518
40SOX2_19829295_ChIP-Seq_ESCs_Human1.48861546
41NANOG_19829295_ChIP-Seq_ESCs_Human1.48861546
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.47415376
43TP53_22573176_ChIP-Seq_HFKS_Human1.46923842
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40409964
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.38336052
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34841865
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34101104
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34098352
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33970911
50GATA3_26560356_Chip-Seq_TH2_Human1.33746535
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32620851
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31926670
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.30617340
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30617340
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28230100
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27108415
57GBX2_23144817_ChIP-Seq_PC3_Human1.26245563
58ER_23166858_ChIP-Seq_MCF-7_Human1.26129150
59AR_20517297_ChIP-Seq_VCAP_Human1.24812917
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.24107300
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22351394
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21964230
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21904998
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21442238
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20729041
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18981606
67HTT_18923047_ChIP-ChIP_STHdh_Human1.17257537
68BCAT_22108803_ChIP-Seq_LS180_Human1.16376680
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16352390
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13808122
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09701856
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09620896
73CBP_20019798_ChIP-Seq_JUKART_Human1.09620896
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09224124
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06705504
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06669320
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.06131788
78MYB_26560356_Chip-Seq_TH2_Human1.04915323
79P53_22387025_ChIP-Seq_ESCs_Mouse1.03415022
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01208685
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.01182569
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00044774
83SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99747146
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99571335
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99050188
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.98974905
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.98425711
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.98245240
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.98086645
90P300_18555785_Chip-Seq_ESCs_Mouse0.97044545
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96436243
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95484369
93GATA1_22025678_ChIP-Seq_K562_Human0.94987558
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.93555446
95NCOR_22424771_ChIP-Seq_293T_Human0.93486307
96IRF1_19129219_ChIP-ChIP_H3396_Human0.91894618
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91238457
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.90908873
99* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90870810
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90542432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.51838308
2MP0005671_abnormal_response_to3.09225360
3MP0001835_abnormal_antigen_presentation2.72612697
4MP0002837_dystrophic_cardiac_calcinosis2.51952311
5MP0003195_calcinosis2.45513233
6MP0009697_abnormal_copulation2.42866598
7MP0003806_abnormal_nucleotide_metabolis2.38253433
8MP0003646_muscle_fatigue2.38139791
9MP0006072_abnormal_retinal_apoptosis2.20526473
10MP0008877_abnormal_DNA_methylation2.17392996
11MP0003724_increased_susceptibility_to2.14767116
12MP0009785_altered_susceptibility_to2.09807710
13MP0005084_abnormal_gallbladder_morpholo2.05778443
14MP0006036_abnormal_mitochondrial_physio1.98072639
15MP0008872_abnormal_physiological_respon1.96357162
16MP0002148_abnormal_hypersensitivity_rea1.90694495
17MP0003186_abnormal_redox_activity1.86826674
18MP0009379_abnormal_foot_pigmentation1.82833120
19MP0006292_abnormal_olfactory_placode1.77051018
20MP0005645_abnormal_hypothalamus_physiol1.69672763
21MP0008058_abnormal_DNA_repair1.66385483
22MP0000569_abnormal_digit_pigmentation1.64590012
23MP0005075_abnormal_melanosome_morpholog1.62231103
24MP0001800_abnormal_humoral_immune1.61264873
25MP0003011_delayed_dark_adaptation1.60511271
26MP0002277_abnormal_respiratory_mucosa1.58075481
27MP0001790_abnormal_immune_system1.46640411
28MP0005387_immune_system_phenotype1.46640411
29MP0001986_abnormal_taste_sensitivity1.46459469
30MP0000685_abnormal_immune_system1.46387867
31MP0004142_abnormal_muscle_tone1.45817672
32MP0005000_abnormal_immune_tolerance1.45781328
33MP0001968_abnormal_touch/_nociception1.45236998
34MP0005551_abnormal_eye_electrophysiolog1.45120048
35MP0002138_abnormal_hepatobiliary_system1.43281924
36MP0004885_abnormal_endolymph1.42232864
37MP0002166_altered_tumor_susceptibility1.41764733
38MP0004043_abnormal_pH_regulation1.41440162
39MP0006082_CNS_inflammation1.40366681
40MP0001853_heart_inflammation1.38736304
41MP0002723_abnormal_immune_serum1.36205104
42MP0004145_abnormal_muscle_electrophysio1.35212029
43MP0003786_premature_aging1.34029248
44MP0002420_abnormal_adaptive_immunity1.29702702
45MP0003656_abnormal_erythrocyte_physiolo1.29634486
46MP0002638_abnormal_pupillary_reflex1.27309742
47MP0001819_abnormal_immune_cell1.26497198
48MP0003787_abnormal_imprinting1.26301664
49MP0005253_abnormal_eye_physiology1.26053668
50MP0002006_tumorigenesis1.24922615
51MP0002452_abnormal_antigen_presenting1.24749178
52MP0004215_abnormal_myocardial_fiber1.23380274
53MP0005025_abnormal_response_to1.22848820
54MP0009764_decreased_sensitivity_to1.20818404
55MP0005636_abnormal_mineral_homeostasis1.19934392
56MP0002736_abnormal_nociception_after1.19723228
57MP0000372_irregular_coat_pigmentation1.17832121
58MP0005167_abnormal_blood-brain_barrier1.16187181
59MP0003718_maternal_effect1.15167586
60MP0002693_abnormal_pancreas_physiology1.13692605
61MP0005174_abnormal_tail_pigmentation1.11557372
62MP0009333_abnormal_splenocyte_physiolog1.11230277
63MP0008875_abnormal_xenobiotic_pharmacok1.10008119
64MP0005464_abnormal_platelet_physiology1.09980383
65MP0002398_abnormal_bone_marrow1.08546662
66MP0000689_abnormal_spleen_morphology1.04228174
67MP0008995_early_reproductive_senescence1.01137790
68MP0002139_abnormal_hepatobiliary_system1.01000427
69MP0001764_abnormal_homeostasis1.00464327
70MP0002163_abnormal_gland_morphology0.98259440
71MP0000716_abnormal_immune_system0.98198669
72MP0003252_abnormal_bile_duct0.97282474
73MP0006035_abnormal_mitochondrial_morpho0.96505161
74MP0002102_abnormal_ear_morphology0.94397980
75MP0001845_abnormal_inflammatory_respons0.93090995
76MP0002419_abnormal_innate_immunity0.92755390
77MP0005085_abnormal_gallbladder_physiolo0.92358000
78MP0001485_abnormal_pinna_reflex0.92202290
79MP0005379_endocrine/exocrine_gland_phen0.90791503
80MP0008469_abnormal_protein_level0.89972872
81MP0001529_abnormal_vocalization0.88929575
82MP0005410_abnormal_fertilization0.87755048
83MP0001905_abnormal_dopamine_level0.84718744
84MP0002405_respiratory_system_inflammati0.83657714
85MP0005332_abnormal_amino_acid0.83644158
86MP0009745_abnormal_behavioral_response0.83301706
87MP0000516_abnormal_urinary_system0.80917930
88MP0005367_renal/urinary_system_phenotyp0.80917930
89MP0002722_abnormal_immune_system0.80572698
90MP0003866_abnormal_defecation0.79508619
91MP0000230_abnormal_systemic_arterial0.79385223
92MP0002429_abnormal_blood_cell0.79382010
93MP0010386_abnormal_urinary_bladder0.79330448
94MP0003121_genomic_imprinting0.74685473
95MP0005266_abnormal_metabolism0.74226745
96MP0002090_abnormal_vision0.72397838
97MP0001545_abnormal_hematopoietic_system0.72062329
98MP0005397_hematopoietic_system_phenotyp0.72062329
99MP0010094_abnormal_chromosome_stability0.71856122
100MP0004084_abnormal_cardiac_muscle0.70209561

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.47917823
2Increased hepatocellular lipid droplets (HP:0006565)4.35031274
33-Methylglutaconic aciduria (HP:0003535)4.24249617
4Mitochondrial inheritance (HP:0001427)4.18118016
5Progressive macrocephaly (HP:0004481)3.96577228
6Lipid accumulation in hepatocytes (HP:0006561)3.96410775
7Acute encephalopathy (HP:0006846)3.90777278
8Abnormal mitochondria in muscle tissue (HP:0008316)3.88404261
9Increased CSF lactate (HP:0002490)3.65833213
10Exertional dyspnea (HP:0002875)3.54971498
11Congenital, generalized hypertrichosis (HP:0004540)3.47277541
12Renal Fanconi syndrome (HP:0001994)3.44503461
13Increased intramyocellular lipid droplets (HP:0012240)3.34577506
14Hepatocellular necrosis (HP:0001404)3.19610358
15Hepatic necrosis (HP:0002605)3.15039568
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92648787
17Stomatitis (HP:0010280)2.91498200
18Aplastic anemia (HP:0001915)2.90193710
19Abnormality of B cell number (HP:0010975)2.84286426
20Pancreatic cysts (HP:0001737)2.83622172
21Cerebral edema (HP:0002181)2.79599525
22Hypothermia (HP:0002045)2.78736149
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77791218
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77791218
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73554915
26Increased muscle lipid content (HP:0009058)2.73148775
27Congenital stationary night blindness (HP:0007642)2.72495395
28IgG deficiency (HP:0004315)2.52894809
29Abnormality of renal resorption (HP:0011038)2.51472836
30Methylmalonic acidemia (HP:0002912)2.50621037
31Optic disc pallor (HP:0000543)2.50585278
32Hypoproteinemia (HP:0003075)2.42345635
33Abnormal number of erythroid precursors (HP:0012131)2.40709209
34Molar tooth sign on MRI (HP:0002419)2.40140488
35Abnormality of midbrain morphology (HP:0002418)2.40140488
36Abolished electroretinogram (ERG) (HP:0000550)2.40066364
37Abnormality of urine glucose concentration (HP:0011016)2.39915880
38Glycosuria (HP:0003076)2.39915880
39Pancreatic fibrosis (HP:0100732)2.39743273
40Lactic acidosis (HP:0003128)2.37600378
41B lymphocytopenia (HP:0010976)2.34831309
42Generalized aminoaciduria (HP:0002909)2.32727570
43Thyroiditis (HP:0100646)2.31802212
44Respiratory difficulties (HP:0002880)2.29308783
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.27107646
46True hermaphroditism (HP:0010459)2.25846352
47Azoospermia (HP:0000027)2.24123193
48Respiratory failure (HP:0002878)2.23471865
49Abnormality of T cell number (HP:0011839)2.20204815
50Elevated erythrocyte sedimentation rate (HP:0003565)2.19430994
51Increased serum lactate (HP:0002151)2.17882326
52Severe combined immunodeficiency (HP:0004430)2.17697516
53Nephronophthisis (HP:0000090)2.13615193
54Abnormality of cells of the erythroid lineage (HP:0012130)2.12826590
55IgM deficiency (HP:0002850)2.12745123
56Renal cortical cysts (HP:0000803)2.11220636
57Abnormality of the renal cortex (HP:0011035)2.09145305
58Abnormal spermatogenesis (HP:0008669)2.09001271
59Autoimmune hemolytic anemia (HP:0001890)2.05276297
60Exercise intolerance (HP:0003546)2.05068478
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.03998493
62Fair hair (HP:0002286)2.01954668
63Lethargy (HP:0001254)2.01415304
64Leukodystrophy (HP:0002415)2.01071510
65Autoimmune thrombocytopenia (HP:0001973)2.00149467
66Increased IgM level (HP:0003496)1.97691210
67Abnormality of the prostate (HP:0008775)1.96686220
68Panhypogammaglobulinemia (HP:0003139)1.94582321
69Oral leukoplakia (HP:0002745)1.94135970
70Eosinophilia (HP:0001880)1.93920233
71Abnormal rod and cone electroretinograms (HP:0008323)1.93872453
72Methylmalonic aciduria (HP:0012120)1.91686105
73Hypoplasia of the fovea (HP:0007750)1.89978425
74Aplasia/Hypoplasia of the fovea (HP:0008060)1.89978425
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89841172
76Abnormality of alanine metabolism (HP:0010916)1.89841172
77Hyperalaninemia (HP:0003348)1.89841172
78T lymphocytopenia (HP:0005403)1.89440609
79Hyperglycinuria (HP:0003108)1.88902096
80Attenuation of retinal blood vessels (HP:0007843)1.87354301
81Abnormality of eosinophils (HP:0001879)1.84863318
82Abnormality of T cells (HP:0002843)1.82430326
83Macrocytic anemia (HP:0001972)1.79175358
84Abnormality of the renal medulla (HP:0100957)1.75541361
85Retrobulbar optic neuritis (HP:0100654)1.74792829
86Optic neuritis (HP:0100653)1.74792829
87Hypochromic microcytic anemia (HP:0004840)1.73815594
88Poikilocytosis (HP:0004447)1.73616807
89Combined immunodeficiency (HP:0005387)1.72999545
90Hyperphosphaturia (HP:0003109)1.72631027
91Nausea (HP:0002018)1.72281384
92Encephalitis (HP:0002383)1.71896010
93Abnormal drinking behavior (HP:0030082)1.70510795
94Polydipsia (HP:0001959)1.70510795
95Abnormal biliary tract physiology (HP:0012439)1.68284482
96Bile duct proliferation (HP:0001408)1.68284482
97Abnormality of the fovea (HP:0000493)1.68167282
98Male pseudohermaphroditism (HP:0000037)1.66810281
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64310029
100Leukocytosis (HP:0001974)1.64114377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.08561139
2VRK22.91890058
3TXK2.89401629
4MST42.86206180
5NUAK12.53581267
6ADRBK22.43879522
7MAP3K122.28179305
8ZAK2.24058635
9TAOK32.18955544
10VRK12.06499590
11BMPR1B2.05561426
12GRK11.84071435
13TEC1.78230857
14ACVR1B1.77968696
15TLK11.74629031
16EIF2AK11.72802671
17PINK11.71357539
18WNK31.69551162
19TIE11.68359654
20MAP4K21.64162463
21EIF2AK31.63038084
22STK161.56050021
23KIT1.51308641
24KDR1.50212015
25TNIK1.40064550
26NME11.35359209
27TAF11.27906613
28SYK1.25912480
29MYLK1.22327994
30CDC71.22120854
31PLK31.19495383
32INSRR1.18814691
33ITK1.17601147
34BCKDK1.16943312
35OBSCN1.16767558
36PLK41.08169265
37OXSR11.06434603
38FES1.03152738
39WNK40.97073818
40GRK70.95732460
41LYN0.95279995
42MKNK20.94963329
43IRAK10.92143536
44MAP4K10.91486824
45IKBKB0.89661719
46PASK0.89531654
47NLK0.87599795
48DYRK20.83238338
49PLK20.82910763
50BMPR20.82104648
51PIK3CG0.81991526
52BUB10.81056852
53PHKG10.79540973
54PHKG20.79540973
55MATK0.79173926
56STK30.78639185
57MAPK130.74007301
58GRK60.73527191
59BTK0.72459115
60MKNK10.70568155
61IKBKE0.70337479
62SRPK10.67021843
63PRKCE0.66603856
64PIM10.66045280
65CDK190.64840864
66ADRBK10.64760478
67STK240.64433607
68RPS6KA50.61268744
69PRKCQ0.60967825
70LCK0.60394861
71CSF1R0.60052231
72TRPM70.59672411
73NEK10.56770334
74PBK0.55941271
75IRAK20.55695430
76DYRK30.55177595
77CSK0.54073753
78MAPKAPK30.53310337
79TGFBR10.52888671
80MARK30.52500153
81STK40.52350617
82BRSK20.51590590
83TAOK10.50994878
84JAK30.49531566
85STK38L0.48522658
86RIPK40.48257738
87PAK30.47165017
88CSNK2A10.45772599
89PIK3CA0.43902640
90PRKG10.43824453
91CAMKK20.43702834
92PKN10.43070525
93PTK2B0.39462044
94CSNK2A20.39419000
95DAPK20.39295885
96STK390.38899173
97MUSK0.38100479
98PRKACA0.37986134
99PLK10.37767037
100BLK0.37388983

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.08263373
2Proteasome_Homo sapiens_hsa030503.33633952
3Parkinsons disease_Homo sapiens_hsa050123.32480040
4Asthma_Homo sapiens_hsa053102.92375916
5Ribosome_Homo sapiens_hsa030102.83853155
6Protein export_Homo sapiens_hsa030602.68885124
7Graft-versus-host disease_Homo sapiens_hsa053322.58108377
8Allograft rejection_Homo sapiens_hsa053302.46682104
9Autoimmune thyroid disease_Homo sapiens_hsa053202.35536268
10Type I diabetes mellitus_Homo sapiens_hsa049402.27035967
11Primary immunodeficiency_Homo sapiens_hsa053402.25819667
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.18835504
13Alzheimers disease_Homo sapiens_hsa050102.16514259
14Huntingtons disease_Homo sapiens_hsa050162.09589590
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03872901
16RNA polymerase_Homo sapiens_hsa030201.96677030
17Homologous recombination_Homo sapiens_hsa034401.80849653
18Cardiac muscle contraction_Homo sapiens_hsa042601.77917556
19Nitrogen metabolism_Homo sapiens_hsa009101.70119905
20Basal transcription factors_Homo sapiens_hsa030221.67995865
21Antigen processing and presentation_Homo sapiens_hsa046121.67038355
22Phototransduction_Homo sapiens_hsa047441.61257121
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58343061
24Rheumatoid arthritis_Homo sapiens_hsa053231.57232954
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42720600
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.39648283
27Hematopoietic cell lineage_Homo sapiens_hsa046401.38103251
28Staphylococcus aureus infection_Homo sapiens_hsa051501.35406099
29Mismatch repair_Homo sapiens_hsa034301.34108463
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32898562
31RNA degradation_Homo sapiens_hsa030181.25692684
32Regulation of autophagy_Homo sapiens_hsa041401.18512607
33Propanoate metabolism_Homo sapiens_hsa006401.16174951
34Linoleic acid metabolism_Homo sapiens_hsa005911.15343140
35Fanconi anemia pathway_Homo sapiens_hsa034601.14839329
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10507053
37Collecting duct acid secretion_Homo sapiens_hsa049661.10054143
38Caffeine metabolism_Homo sapiens_hsa002321.07125733
39Nucleotide excision repair_Homo sapiens_hsa034201.03805326
40Non-homologous end-joining_Homo sapiens_hsa034500.98791998
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96434348
42One carbon pool by folate_Homo sapiens_hsa006700.95790466
43Chemical carcinogenesis_Homo sapiens_hsa052040.95500727
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94405520
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93781491
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91482902
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88662032
48Spliceosome_Homo sapiens_hsa030400.88514339
49Selenocompound metabolism_Homo sapiens_hsa004500.88499522
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86657139
51Peroxisome_Homo sapiens_hsa041460.83337044
52DNA replication_Homo sapiens_hsa030300.81678385
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80229329
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79975716
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.79636987
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79244242
57Tryptophan metabolism_Homo sapiens_hsa003800.78355373
58Purine metabolism_Homo sapiens_hsa002300.76781018
59Leishmaniasis_Homo sapiens_hsa051400.76502751
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75910264
61Pyrimidine metabolism_Homo sapiens_hsa002400.74866652
62Base excision repair_Homo sapiens_hsa034100.73426452
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73371188
64Ether lipid metabolism_Homo sapiens_hsa005650.71970887
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71957421
66Butanoate metabolism_Homo sapiens_hsa006500.70563651
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69082795
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67519976
69Retinol metabolism_Homo sapiens_hsa008300.67267955
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65878567
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63259476
72Systemic lupus erythematosus_Homo sapiens_hsa053220.62705972
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62000838
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57891287
75Glutathione metabolism_Homo sapiens_hsa004800.56399216
76Olfactory transduction_Homo sapiens_hsa047400.53883842
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53634582
78Viral myocarditis_Homo sapiens_hsa054160.51805953
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51751861
80Vitamin digestion and absorption_Homo sapiens_hsa049770.50139516
81Metabolic pathways_Homo sapiens_hsa011000.49120464
82Fatty acid elongation_Homo sapiens_hsa000620.48091652
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47785944
84African trypanosomiasis_Homo sapiens_hsa051430.45963540
85Herpes simplex infection_Homo sapiens_hsa051680.45777317
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43492573
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43168326
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.42872126
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.40806488
90Mineral absorption_Homo sapiens_hsa049780.38030783
91Legionellosis_Homo sapiens_hsa051340.37992698
92Sulfur metabolism_Homo sapiens_hsa009200.37732902
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33361640
94Pyruvate metabolism_Homo sapiens_hsa006200.32865758
95Fatty acid degradation_Homo sapiens_hsa000710.31032906
96Folate biosynthesis_Homo sapiens_hsa007900.29328504
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.27928635
98Measles_Homo sapiens_hsa051620.27785806
99Epstein-Barr virus infection_Homo sapiens_hsa051690.27391771
100Malaria_Homo sapiens_hsa051440.27093382

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