EIF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)8.27008217
2mucosal immune response (GO:0002385)6.85380391
3organ or tissue specific immune response (GO:0002251)6.51880157
4antibacterial humoral response (GO:0019731)6.37094911
5antimicrobial humoral response (GO:0019730)5.85261901
6immunoglobulin mediated immune response (GO:0016064)5.63562691
7positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.45392987
8T-helper 1 type immune response (GO:0042088)5.31024008
9regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.19852296
10DNA deamination (GO:0045006)4.87483681
11B cell mediated immunity (GO:0019724)4.75417525
12chromatin assembly (GO:0031497)4.67962627
13positive regulation of humoral immune response (GO:0002922)4.49860266
14antigen processing and presentation of endogenous antigen (GO:0019883)4.42928506
15nucleosome assembly (GO:0006334)4.31009274
16negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.16607973
17positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.14647813
18regulation of interferon-gamma biosynthetic process (GO:0045072)4.09464130
19negative regulation of B cell apoptotic process (GO:0002903)4.04962209
20B cell proliferation (GO:0042100)4.01746417
21interferon-gamma-mediated signaling pathway (GO:0060333)3.99612853
22cellular response to interleukin-15 (GO:0071350)3.99329712
23positive regulation of T cell mediated cytotoxicity (GO:0001916)3.98098127
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92222050
25tongue development (GO:0043586)3.88627706
26positive regulation of alpha-beta T cell proliferation (GO:0046641)3.85079432
27negative thymic T cell selection (GO:0045060)3.82905261
28protein-DNA complex assembly (GO:0065004)3.81887468
29positive regulation of macrophage cytokine production (GO:0060907)3.79595655
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78691830
31ATP synthesis coupled proton transport (GO:0015986)3.75125407
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75125407
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.72178253
34DNA replication-dependent nucleosome organization (GO:0034723)3.68608132
35DNA replication-dependent nucleosome assembly (GO:0006335)3.68608132
36viral transcription (GO:0019083)3.63559299
37B cell receptor signaling pathway (GO:0050853)3.62938671
38T cell migration (GO:0072678)3.58442944
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55339636
40production of molecular mediator of immune response (GO:0002440)3.51351356
41translational termination (GO:0006415)3.50731126
42translational elongation (GO:0006414)3.50561329
43negative T cell selection (GO:0043383)3.47393156
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.47341933
45regulation of T cell mediated cytotoxicity (GO:0001914)3.47311523
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44737881
47negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.41472754
48nucleosome organization (GO:0034728)3.40603134
49regulation of B cell apoptotic process (GO:0002902)3.39506991
50regulation of B cell receptor signaling pathway (GO:0050855)3.38992916
51response to interleukin-15 (GO:0070672)3.38700324
52B cell homeostasis (GO:0001782)3.37571094
53positive regulation of immunoglobulin mediated immune response (GO:0002891)3.35461038
54positive regulation of B cell mediated immunity (GO:0002714)3.35461038
55endoderm formation (GO:0001706)3.34368110
56detection of bacterium (GO:0016045)3.32998337
57cellular response to type I interferon (GO:0071357)3.32790104
58type I interferon signaling pathway (GO:0060337)3.32790104
59negative regulation of B cell proliferation (GO:0030889)3.29077303
60myeloid dendritic cell differentiation (GO:0043011)3.26617211
61positive regulation of interleukin-12 production (GO:0032735)3.24255881
62nucleotide salvage (GO:0043173)3.23116657
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23004870
64response to type I interferon (GO:0034340)3.22360233
65regulation of isotype switching to IgG isotypes (GO:0048302)3.21348481
66cellular response to interferon-beta (GO:0035458)3.20017906
67regulation of alpha-beta T cell proliferation (GO:0046640)3.17002956
68CTP biosynthetic process (GO:0006241)3.16807123
69CTP metabolic process (GO:0046036)3.16807123
70pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.16081176
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15177901
72positive regulation of cell killing (GO:0031343)3.11909758
73cellular response to interferon-gamma (GO:0071346)3.11804850
74protein-DNA complex subunit organization (GO:0071824)3.10998751
75pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.10272864
76regulation of immunoglobulin secretion (GO:0051023)3.08993252
77positive regulation of interferon-gamma production (GO:0032729)3.07546249
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.07401391
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05701201
80regulation of B cell proliferation (GO:0030888)3.03266931
81pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.02967379
82defense response to Gram-positive bacterium (GO:0050830)3.02216094
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.00102578
84protein targeting to ER (GO:0045047)2.98789795
85cotranslational protein targeting to membrane (GO:0006613)2.98601241
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98508831
87cytidine deamination (GO:0009972)2.98037103
88cytidine metabolic process (GO:0046087)2.98037103
89cytidine catabolic process (GO:0006216)2.98037103
90pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.97112232
91nucleoside salvage (GO:0043174)2.95538260
92myeloid dendritic cell activation (GO:0001773)2.94537333
93lymphocyte costimulation (GO:0031294)2.94535066
94regulation of antigen processing and presentation (GO:0002577)2.94052637
95T cell costimulation (GO:0031295)2.92256405
96positive regulation of prostaglandin secretion (GO:0032308)2.92187236
97humoral immune response (GO:0006959)2.91772492
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.90120015
99GTP biosynthetic process (GO:0006183)2.89059190
100regulation of inflammatory response to antigenic stimulus (GO:0002861)2.85755108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.17370178
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.44068805
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.33585433
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25157514
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13690873
6SOX2_16153702_ChIP-ChIP_HESCs_Human2.93066735
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90634691
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90094154
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.67444716
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60284441
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.48108650
12RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.39553679
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20837360
14HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.19820854
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.14581546
16ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.13173460
17IRF1_19129219_ChIP-ChIP_H3396_Human2.10645109
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09477842
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06607729
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06001743
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.7431388
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99466963
23VDR_23849224_ChIP-Seq_CD4+_Human1.93167101
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89070557
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86072001
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82879974
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.69894505
28KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.69432810
29ELK1_19687146_ChIP-ChIP_HELA_Human1.65981321
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63851300
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63458920
32MAF_26560356_Chip-Seq_TH1_Human1.59036525
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58382143
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.56670396
35CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.55341080
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54254761
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.53776360
38MYC_18940864_ChIP-ChIP_HL60_Human1.52466899
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51132053
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50301601
41MYC_22102868_ChIP-Seq_BL_Human1.46824302
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45823734
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43969074
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.43417145
45CIITA_25753668_ChIP-Seq_RAJI_Human1.41537543
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40643271
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40019518
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.37860366
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.34786713
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34179231
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31775470
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26652121
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26469909
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25966037
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25783182
56FOXP3_21729870_ChIP-Seq_TREG_Human1.25542664
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.23446338
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22251304
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20763551
60VDR_21846776_ChIP-Seq_THP-1_Human1.20217625
61CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18891286
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18400734
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.12513242
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11952768
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10067841
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.08360870
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07163355
68XRN2_22483619_ChIP-Seq_HELA_Human1.05738245
69UTX_26944678_Chip-Seq_JUKART_Human1.02893062
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02778149
71SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98858555
72MYB_26560356_Chip-Seq_TH2_Human0.97797222
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97043651
74MYB_26560356_Chip-Seq_TH1_Human0.97020359
75ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95417855
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95003230
77IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94901167
78SPI1_20517297_ChIP-Seq_HL60_Human0.94847146
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93480803
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92496527
81ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89593343
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88676345
83MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88166218
84BCOR_27268052_Chip-Seq_Bcells_Human0.86640510
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84980409
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80784245
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79404548
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.79217043
89P300_27268052_Chip-Seq_Bcells_Human0.78891991
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78766623
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78733963
92MAF_26560356_Chip-Seq_TH2_Human0.78284711
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77941856
94TTF2_22483619_ChIP-Seq_HELA_Human0.77240838
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76029277
96VDR_24763502_ChIP-Seq_THP-1_Human0.73416655
97DCP1A_22483619_ChIP-Seq_HELA_Human0.71401580
98BCL6_27268052_Chip-Seq_Bcells_Human0.71025710
99E2F1_20622854_ChIP-Seq_HELA_Human0.69470795
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.68986366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol7.18002148
2MP0000685_abnormal_immune_system5.58203402
3MP0005671_abnormal_response_to5.13751029
4MP0001835_abnormal_antigen_presentation4.00291896
5MP0005387_immune_system_phenotype3.79443162
6MP0001790_abnormal_immune_system3.79443162
7MP0002138_abnormal_hepatobiliary_system3.46952616
8MP0001800_abnormal_humoral_immune3.44519056
9MP0005084_abnormal_gallbladder_morpholo3.03332121
10MP0005000_abnormal_immune_tolerance2.96552570
11MP0009046_muscle_twitch2.63325359
12MP0003183_abnormal_peptide_metabolism2.41921735
13MP0002723_abnormal_immune_serum2.35147514
14MP0002452_abnormal_antigen_presenting2.30308423
15MP0003763_abnormal_thymus_physiology2.26153552
16MP0002928_abnormal_bile_duct2.22413476
17MP0009785_altered_susceptibility_to2.21023761
18MP0002420_abnormal_adaptive_immunity2.02803022
19MP0001819_abnormal_immune_cell1.95787838
20MP0001727_abnormal_embryo_implantation1.93266643
21MP0002148_abnormal_hypersensitivity_rea1.92419512
22MP0001348_abnormal_lacrimal_gland1.90340160
23MP0005025_abnormal_response_to1.87163738
24MP0002398_abnormal_bone_marrow1.83067433
25MP0000716_abnormal_immune_system1.72826524
26MP0002166_altered_tumor_susceptibility1.57192429
27MP0000689_abnormal_spleen_morphology1.56013769
28MP0008875_abnormal_xenobiotic_pharmacok1.55189005
29MP0010155_abnormal_intestine_physiology1.51033220
30MP0001845_abnormal_inflammatory_respons1.44240505
31MP0002722_abnormal_immune_system1.42560204
32MP0002163_abnormal_gland_morphology1.42308547
33MP0002429_abnormal_blood_cell1.42038971
34MP0001873_stomach_inflammation1.41072685
35MP0000372_irregular_coat_pigmentation1.37439246
36MP0003724_increased_susceptibility_to1.30388163
37MP0010094_abnormal_chromosome_stability1.29781516
38MP0000631_abnormal_neuroendocrine_gland1.29117077
39MP0001346_abnormal_lacrimal_gland1.28233917
40MP0006292_abnormal_olfactory_placode1.28103713
41MP0002006_tumorigenesis1.26994139
42MP0005310_abnormal_salivary_gland1.23054095
43MP0003806_abnormal_nucleotide_metabolis1.20501324
44MP0000703_abnormal_thymus_morphology1.15440047
45MP0003436_decreased_susceptibility_to1.09357673
46MP0009333_abnormal_splenocyte_physiolog1.07979533
47MP0008872_abnormal_physiological_respon1.07549523
48MP0002419_abnormal_innate_immunity1.04305839
49MP0002139_abnormal_hepatobiliary_system0.99728295
50MP0003303_peritoneal_inflammation0.99492885
51MP0001529_abnormal_vocalization0.99177320
52MP0008058_abnormal_DNA_repair0.95406374
53MP0005623_abnormal_meninges_morphology0.92952306
54MP0002019_abnormal_tumor_incidence0.89098738
55MP0005423_abnormal_somatic_nervous0.85934117
56MP0002405_respiratory_system_inflammati0.83261216
57MP0003186_abnormal_redox_activity0.82208903
58MP0002735_abnormal_chemical_nociception0.81960886
59MP0003077_abnormal_cell_cycle0.81660685
60MP0003011_delayed_dark_adaptation0.77818647
61MP0004742_abnormal_vestibular_system0.77793638
62MP0008469_abnormal_protein_level0.77625145
63MP0001881_abnormal_mammary_gland0.77202895
64MP0002136_abnormal_kidney_physiology0.76028644
65MP0003866_abnormal_defecation0.74717405
66MP0009643_abnormal_urine_homeostasis0.74260208
67MP0000026_abnormal_inner_ear0.73738204
68MP0000343_altered_response_to0.73553588
69MP0001919_abnormal_reproductive_system0.73028467
70MP0002277_abnormal_respiratory_mucosa0.72705821
71MP0004142_abnormal_muscle_tone0.70443597
72MP0008569_lethality_at_weaning0.70335073
73MP0001663_abnormal_digestive_system0.66872760
74MP0003252_abnormal_bile_duct0.65612373
75MP0002693_abnormal_pancreas_physiology0.65131213
76MP0001905_abnormal_dopamine_level0.61024244
77MP0005464_abnormal_platelet_physiology0.60389181
78MP0009763_increased_sensitivity_to0.60297548
79MP0005332_abnormal_amino_acid0.59158355
80MP0005166_decreased_susceptibility_to0.56266294
81MP0009379_abnormal_foot_pigmentation0.55821208
82MP0002272_abnormal_nervous_system0.55087718
83MP0002083_premature_death0.55019002
84MP0005394_taste/olfaction_phenotype0.54572812
85MP0005499_abnormal_olfactory_system0.54572812
86MP0006082_CNS_inflammation0.54380308
87MP0002933_joint_inflammation0.53016369
88MP0003300_gastrointestinal_ulcer0.51855450
89MP0005253_abnormal_eye_physiology0.50831964
90MP0006072_abnormal_retinal_apoptosis0.50028797
91MP0008007_abnormal_cellular_replicative0.48134658
92MP0002837_dystrophic_cardiac_calcinosis0.46192328
93MP0003045_fibrosis0.45665302
94MP0000490_abnormal_crypts_of0.44839179
95MP0004957_abnormal_blastocyst_morpholog0.44079975
96MP0000313_abnormal_cell_death0.44011336
97MP0005075_abnormal_melanosome_morpholog0.43709522
98MP0006035_abnormal_mitochondrial_morpho0.43569422
99MP0009642_abnormal_blood_homeostasis0.42666592
100MP0004145_abnormal_muscle_electrophysio0.42280811

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.65688020
2Recurrent sinusitis (HP:0011108)6.74923980
3IgA deficiency (HP:0002720)6.04193937
4IgM deficiency (HP:0002850)5.71919115
5Recurrent bronchitis (HP:0002837)5.69162187
6Agammaglobulinemia (HP:0004432)5.16732482
7Lymphopenia (HP:0001888)4.76368806
8Dry hair (HP:0011359)4.52703933
9Abnormality of cells of the lymphoid lineage (HP:0012140)4.52334714
10IgG deficiency (HP:0004315)4.45237392
11Vasculitis (HP:0002633)3.97789629
12Emphysema (HP:0002097)3.88078563
13Meningitis (HP:0001287)3.84697822
14Onycholysis (HP:0001806)3.76351065
15Bronchitis (HP:0012387)3.62106845
16Lipid accumulation in hepatocytes (HP:0006561)3.57283359
17Urticaria (HP:0001025)3.49682402
18Recurrent pneumonia (HP:0006532)3.46983409
19Increased hepatocellular lipid droplets (HP:0006565)3.45222775
20Acute necrotizing encephalopathy (HP:0006965)3.44310519
21Increased IgM level (HP:0003496)3.41321252
22Mitochondrial inheritance (HP:0001427)3.32579943
23Abnormal mitochondria in muscle tissue (HP:0008316)3.30583548
24Conical tooth (HP:0000698)3.28135056
25Cellulitis (HP:0100658)3.17131140
26Abnormality of T cell physiology (HP:0011840)3.13402038
27Chronic diarrhea (HP:0002028)3.12348782
28Chronic sinusitis (HP:0011109)3.09519090
29Mediastinal lymphadenopathy (HP:0100721)2.99668188
30Abnormality of the prostate (HP:0008775)2.99061565
31Increased CSF lactate (HP:0002490)2.96689227
32Acute encephalopathy (HP:0006846)2.91939307
33Recurrent lower respiratory tract infections (HP:0002783)2.90683755
34Renal Fanconi syndrome (HP:0001994)2.85960691
35Progressive macrocephaly (HP:0004481)2.83192003
36Recurrent otitis media (HP:0000403)2.82771824
37Abnormality of incisor morphology (HP:0011063)2.80281589
38Squamous cell carcinoma (HP:0002860)2.77580160
39Skin rash (HP:0000988)2.77396352
40Bronchiectasis (HP:0002110)2.76434058
41Restrictive lung disease (HP:0002091)2.70953213
42Abnormal number of erythroid precursors (HP:0012131)2.69946434
43Hepatocellular necrosis (HP:0001404)2.69121358
44Eczematoid dermatitis (HP:0000976)2.67312655
45Prostate neoplasm (HP:0100787)2.63412044
46Hepatic necrosis (HP:0002605)2.63192930
47Abnormal gallbladder physiology (HP:0012438)2.57406982
48Cholecystitis (HP:0001082)2.57406982
49Muscle fiber atrophy (HP:0100295)2.56915358
503-Methylglutaconic aciduria (HP:0003535)2.54658798
51Type 2 muscle fiber atrophy (HP:0003554)2.53912274
52Recurrent bacterial skin infections (HP:0005406)2.53673408
53Hyperglycinemia (HP:0002154)2.53491359
54Abnormality of cells of the erythroid lineage (HP:0012130)2.51132583
55Ridged nail (HP:0001807)2.51067016
56Leukopenia (HP:0001882)2.46628708
57Increased intramyocellular lipid droplets (HP:0012240)2.44035679
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42220392
59Neutropenia (HP:0001875)2.40638574
60Exertional dyspnea (HP:0002875)2.34856663
61Recurrent gram-negative bacterial infections (HP:0005420)2.34515682
62Basal cell carcinoma (HP:0002671)2.32605497
63Increased muscle lipid content (HP:0009058)2.32572058
64Osteomyelitis (HP:0002754)2.28643045
65Erythema (HP:0010783)2.28314118
66Verrucae (HP:0200043)2.26258346
67Papilloma (HP:0012740)2.26258346
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21598093
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21598093
70Premature loss of primary teeth (HP:0006323)2.21136213
71Cerebral edema (HP:0002181)2.21020944
72Abnormality of macrophages (HP:0004311)2.19067217
73Chronic otitis media (HP:0000389)2.18040107
74Exercise intolerance (HP:0003546)2.11599699
75Petechiae (HP:0000967)2.11570137
76Abnormality of T cells (HP:0002843)2.10498193
77Lymphoma (HP:0002665)2.09003363
78Respiratory difficulties (HP:0002880)2.07437987
79Elevated erythrocyte sedimentation rate (HP:0003565)2.06272382
80Abnormality of glycolysis (HP:0004366)2.04516676
81Xerostomia (HP:0000217)2.03424326
82B lymphocytopenia (HP:0010976)2.03016548
83Reticulocytopenia (HP:0001896)2.01483326
84Abnormality of male internal genitalia (HP:0000022)1.99106005
85Abnormal delayed hypersensitivity skin test (HP:0002963)1.98240539
86Increased serum lactate (HP:0002151)1.92245784
87Abnormal respiratory motile cilium morphology (HP:0005938)1.91926452
88Abnormal respiratory epithelium morphology (HP:0012253)1.91926452
89Sepsis (HP:0100806)1.91613019
90Poor suck (HP:0002033)1.90015878
91Arthralgia (HP:0002829)1.89069301
92Obstructive lung disease (HP:0006536)1.88421880
93Chronic obstructive pulmonary disease (HP:0006510)1.88421880
94Abnormality of the pleura (HP:0002103)1.88211685
95Abnormality of B cell number (HP:0010975)1.85830349
96Exercise-induced muscle cramps (HP:0003710)1.78629370
97Recurrent abscess formation (HP:0002722)1.77489206
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76305606
99Palpebral edema (HP:0100540)1.74947099
100Hypertensive crisis (HP:0100735)1.74914204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK17.14913823
2TLK16.66672241
3ZAK6.65804751
4DAPK33.63634178
5VRK23.46032996
6RPS6KA52.87112972
7BCKDK2.82055342
8MAP4K12.38554965
9AURKA2.12602106
10SMG12.00962557
11TAF11.74117932
12RIPK41.73520236
13TSSK61.66262810
14IRAK41.60763834
15BUB11.50102551
16MAP4K21.49365304
17MAPKAPK51.44583068
18SYK1.42641925
19STK41.14491775
20MAP3K141.09641255
21CSF1R1.09404581
22NUAK11.07299159
23IKBKE1.05641284
24IKBKB1.05208603
25NME21.03446433
26BLK1.00807510
27TIE10.99928321
28MAP3K90.93963829
29TNK20.92223059
30AURKB0.89279876
31BTK0.88921950
32PKN10.87642918
33MAP3K130.85722902
34LYN0.85196177
35PRKCQ0.85006516
36KDR0.84348145
37NEK90.78303720
38TBK10.76821504
39CHEK20.75288163
40PASK0.74517457
41ARAF0.72589443
42KIT0.71620957
43WNK30.71309996
44CCNB10.70298077
45PIM10.69426778
46DYRK20.68851058
47CDC70.68719237
48JAK30.67024868
49ADRBK20.66026590
50MST40.54284421
51CDK90.52309645
52MAPK150.51957470
53INSRR0.51492108
54FGFR40.50722961
55CDK190.50035918
56BRAF0.49534973
57NEK10.47178219
58MAP2K20.46719449
59PIM20.46622824
60MAPK70.45506652
61PRKCD0.43531268
62BMPR20.42120265
63ALK0.41800566
64TAOK30.39072331
65TXK0.38993412
66CHUK0.37864002
67AKT20.37828579
68HIPK20.37511671
69NME10.35651367
70OXSR10.32039689
71GRK50.31870786
72GRK10.29729936
73RPS6KB20.29424332
74MAPK120.29277738
75PAK10.29199391
76STK160.28488352
77LCK0.28245887
78CSNK1G10.27946861
79CSNK2A20.27527697
80MAP3K80.26149439
81MAPKAPK30.25959128
82EIF2AK30.25867970
83NLK0.25696880
84ITK0.21688321
85SIK20.19928080
86CDK80.19838346
87INSR0.19264570
88CSNK1G30.18706927
89PDK20.18410763
90JAK20.16410305
91ATR0.15649677
92PRKCH0.15244994
93TYRO30.14704770
94CSNK2A10.14563651
95WEE10.13525253
96TESK20.13490425
97MATK0.13205656
98EIF2AK20.12320083
99PRKCB0.12014379
100ABL10.11908623

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.50188379
2Alcoholism_Homo sapiens_hsa050345.49046401
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.91002828
4Allograft rejection_Homo sapiens_hsa053303.76014643
5Asthma_Homo sapiens_hsa053103.57469980
6Autoimmune thyroid disease_Homo sapiens_hsa053203.45381091
7Primary immunodeficiency_Homo sapiens_hsa053402.96233307
8Graft-versus-host disease_Homo sapiens_hsa053322.91439250
9Type I diabetes mellitus_Homo sapiens_hsa049402.67372934
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38810839
11Viral myocarditis_Homo sapiens_hsa054162.13318902
12Viral carcinogenesis_Homo sapiens_hsa052032.02690032
13Ribosome_Homo sapiens_hsa030101.93576849
14Antigen processing and presentation_Homo sapiens_hsa046121.80073287
15Oxidative phosphorylation_Homo sapiens_hsa001901.79681261
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78193697
17Parkinsons disease_Homo sapiens_hsa050121.54562989
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47994789
19Proteasome_Homo sapiens_hsa030501.39871455
20Sulfur relay system_Homo sapiens_hsa041221.32278019
21Leishmaniasis_Homo sapiens_hsa051401.30909516
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16352031
23Staphylococcus aureus infection_Homo sapiens_hsa051501.16308935
24Rheumatoid arthritis_Homo sapiens_hsa053231.14579655
25DNA replication_Homo sapiens_hsa030301.07174389
26B cell receptor signaling pathway_Homo sapiens_hsa046621.01309720
27Huntingtons disease_Homo sapiens_hsa050160.96173054
28Phenylalanine metabolism_Homo sapiens_hsa003600.94597991
29Hematopoietic cell lineage_Homo sapiens_hsa046400.92721598
30Alzheimers disease_Homo sapiens_hsa050100.92318527
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88250712
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81631954
33Epstein-Barr virus infection_Homo sapiens_hsa051690.78651617
34Pentose phosphate pathway_Homo sapiens_hsa000300.77096470
35Herpes simplex infection_Homo sapiens_hsa051680.76878636
36Mismatch repair_Homo sapiens_hsa034300.72528310
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69578537
38Spliceosome_Homo sapiens_hsa030400.66621806
39Influenza A_Homo sapiens_hsa051640.63249773
40Cardiac muscle contraction_Homo sapiens_hsa042600.62902569
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62052551
42Tryptophan metabolism_Homo sapiens_hsa003800.61441990
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56593115
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54371708
45Measles_Homo sapiens_hsa051620.50084670
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.46800702
47Pyrimidine metabolism_Homo sapiens_hsa002400.46650981
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.45360042
49Homologous recombination_Homo sapiens_hsa034400.45146776
50Carbon metabolism_Homo sapiens_hsa012000.44311250
51Phagosome_Homo sapiens_hsa041450.44024559
52Tyrosine metabolism_Homo sapiens_hsa003500.42719788
53Toxoplasmosis_Homo sapiens_hsa051450.39234539
54Protein export_Homo sapiens_hsa030600.39096548
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.38991579
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38983495
57RNA polymerase_Homo sapiens_hsa030200.37704861
58Nucleotide excision repair_Homo sapiens_hsa034200.37456940
59Butanoate metabolism_Homo sapiens_hsa006500.37418382
60Base excision repair_Homo sapiens_hsa034100.37391806
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35577837
62Biosynthesis of amino acids_Homo sapiens_hsa012300.35531165
63One carbon pool by folate_Homo sapiens_hsa006700.33361089
64p53 signaling pathway_Homo sapiens_hsa041150.32894425
65Fructose and mannose metabolism_Homo sapiens_hsa000510.32625548
66RNA degradation_Homo sapiens_hsa030180.32561826
67HTLV-I infection_Homo sapiens_hsa051660.29875136
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27360024
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25820741
70Apoptosis_Homo sapiens_hsa042100.25359198
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24004281
72Tuberculosis_Homo sapiens_hsa051520.23750697
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22476381
74Glutathione metabolism_Homo sapiens_hsa004800.22376201
75Selenocompound metabolism_Homo sapiens_hsa004500.20405308
76Pyruvate metabolism_Homo sapiens_hsa006200.20385246
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19748347
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19360235
79Propanoate metabolism_Homo sapiens_hsa006400.12386643
80Purine metabolism_Homo sapiens_hsa002300.11965400
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10790900
82Nitrogen metabolism_Homo sapiens_hsa009100.09953277
83Peroxisome_Homo sapiens_hsa041460.09772468
84African trypanosomiasis_Homo sapiens_hsa051430.09090442
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.07694214
86Metabolic pathways_Homo sapiens_hsa011000.06300305
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05121326
88Chemokine signaling pathway_Homo sapiens_hsa040620.04681214
89Malaria_Homo sapiens_hsa051440.03615753
90Fanconi anemia pathway_Homo sapiens_hsa034600.02916117
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.01685771
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00164486
93Basal transcription factors_Homo sapiens_hsa03022-0.0410265
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.0385085
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0276483
96Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0184031
97Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0151772
98T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0136176
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0051274
100Fatty acid degradation_Homo sapiens_hsa00071-0.0046565

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