EIF1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)6.18550655
2proteasome assembly (GO:0043248)5.95776122
3UV protection (GO:0009650)5.44735201
4rRNA modification (GO:0000154)5.36886500
5rRNA methylation (GO:0031167)5.34711384
6necroptotic process (GO:0070266)5.32567823
7motile cilium assembly (GO:0044458)5.00340172
8regulation of skeletal muscle contraction (GO:0014819)4.85975997
9negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.64417637
10NIK/NF-kappaB signaling (GO:0038061)4.63437838
11sphingomyelin metabolic process (GO:0006684)4.48414824
12GDP-mannose metabolic process (GO:0019673)4.43859500
13nucleotide transmembrane transport (GO:1901679)4.30995340
14purinergic nucleotide receptor signaling pathway (GO:0035590)4.26645135
15DNA strand renaturation (GO:0000733)4.16237466
16RNA methylation (GO:0001510)4.12497600
17negative regulation of cell aging (GO:0090344)4.04930444
18protein localization to peroxisome (GO:0072662)3.97568368
19protein targeting to peroxisome (GO:0006625)3.97568368
20establishment of protein localization to peroxisome (GO:0072663)3.97568368
21iron-sulfur cluster assembly (GO:0016226)3.92084612
22metallo-sulfur cluster assembly (GO:0031163)3.92084612
23regulation of female gonad development (GO:2000194)3.81506548
24regulation of protein polyubiquitination (GO:1902914)3.80002674
25AMP metabolic process (GO:0046033)3.79270999
26regulation of necroptotic process (GO:0060544)3.79070243
27purine ribonucleotide transport (GO:0015868)3.78988800
28regulation of RIG-I signaling pathway (GO:0039535)3.77693528
29cullin deneddylation (GO:0010388)3.77021651
30programmed necrotic cell death (GO:0097300)3.71506158
31cellular response to exogenous dsRNA (GO:0071360)3.67238935
32peroxisomal transport (GO:0043574)3.66299447
33segment specification (GO:0007379)3.57470387
34protein deneddylation (GO:0000338)3.54116424
35nucleoside transmembrane transport (GO:1901642)3.51416724
36pseudouridine synthesis (GO:0001522)3.47617657
37adenine nucleotide transport (GO:0051503)3.47415123
38negative regulation of necroptotic process (GO:0060546)3.47100392
39centriole assembly (GO:0098534)3.45849663
40DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45087664
41positive regulation of defense response to virus by host (GO:0002230)3.40811613
42peroxisome fission (GO:0016559)3.40388914
43chaperone-mediated protein transport (GO:0072321)3.35983706
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35090513
45DNA damage response, signal transduction resulting in transcription (GO:0042772)3.34036562
46G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.30771764
47fat-soluble vitamin biosynthetic process (GO:0042362)3.26009615
48necrotic cell death (GO:0070265)3.25891066
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25638280
50response to ATP (GO:0033198)3.20782901
51nucleotide transport (GO:0006862)3.16046137
52nucleotide-excision repair, DNA damage removal (GO:0000718)3.15938275
53DNA excision (GO:0044349)3.15938275
54adenosine receptor signaling pathway (GO:0001973)3.10538313
55myoblast migration (GO:0051451)3.08284230
56meiotic chromosome segregation (GO:0045132)3.05310583
57regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.05032116
58RNA modification (GO:0009451)3.03033957
59regulation of DNA endoreduplication (GO:0032875)3.02815393
60DNA catabolic process, endonucleolytic (GO:0000737)3.00628875
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00166146
62intracellular protein transmembrane import (GO:0044743)2.99581843
63mature B cell differentiation (GO:0002335)2.99294197
64behavioral response to nicotine (GO:0035095)2.99007203
65folic acid metabolic process (GO:0046655)2.97760077
66regulation of immunoglobulin secretion (GO:0051023)2.97526910
67grooming behavior (GO:0007625)2.95484297
68negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.92677914
69protein localization to Golgi apparatus (GO:0034067)2.89997227
70phosphatidylinositol dephosphorylation (GO:0046856)2.89858693
71ribosomal large subunit biogenesis (GO:0042273)2.88579657
72DNA deamination (GO:0045006)2.83125643
73detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.83094947
74purinergic receptor signaling pathway (GO:0035587)2.82796398
75positive regulation of protein homodimerization activity (GO:0090073)2.82239500
76response to gravity (GO:0009629)2.81635988
77phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78908324
78inositol phosphate dephosphorylation (GO:0046855)2.78908324
79base-excision repair, AP site formation (GO:0006285)2.77825108
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77401949
81regulation of memory T cell differentiation (GO:0043380)2.75482962
82tRNA modification (GO:0006400)2.75325655
83regulation of glycogen (starch) synthase activity (GO:2000465)2.73345037
84intra-S DNA damage checkpoint (GO:0031573)2.73124112
85positive regulation of mitochondrial fission (GO:0090141)2.72088612
86negative regulation by host of viral transcription (GO:0043922)2.71408530
87nucleoside transport (GO:0015858)2.69450887
88negative regulation of necrotic cell death (GO:0060547)2.68053076
89ADP metabolic process (GO:0046031)2.66110082
90vitamin biosynthetic process (GO:0009110)2.62952355
91DNA catabolic process (GO:0006308)2.62195770
92positive regulation of protein homooligomerization (GO:0032464)2.62163513
93cellular response to virus (GO:0098586)2.61541427
94type B pancreatic cell proliferation (GO:0044342)2.60964672
95regulation of acyl-CoA biosynthetic process (GO:0050812)2.60827640
96regulation of necrotic cell death (GO:0010939)2.60715789
97regulation of mitochondrial translation (GO:0070129)2.60372564
98regulation of cofactor metabolic process (GO:0051193)2.58269677
99regulation of coenzyme metabolic process (GO:0051196)2.58269677
100organelle membrane fusion (GO:0090174)2.56849483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32712973
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28355112
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.27281161
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24467743
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19995229
6VDR_21846776_ChIP-Seq_THP-1_Human3.04013662
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64120071
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59943507
9DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.56824074
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.56606447
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48792396
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36859202
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.35463831
14XRN2_22483619_ChIP-Seq_HELA_Human2.31664047
15P68_20966046_ChIP-Seq_HELA_Human2.20142510
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17541624
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12910968
18VDR_23849224_ChIP-Seq_CD4+_Human2.05024741
19THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97801267
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96516784
21DCP1A_22483619_ChIP-Seq_HELA_Human1.95058322
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.93068498
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90826496
24VDR_24763502_ChIP-Seq_THP-1_Human1.83112684
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82852267
26GABP_19822575_ChIP-Seq_HepG2_Human1.76871431
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.74578114
28FOXP3_21729870_ChIP-Seq_TREG_Human1.72502102
29BCL6_27268052_Chip-Seq_Bcells_Human1.71811246
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.71615742
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71180843
32E2F1_20622854_ChIP-Seq_HELA_Human1.68731451
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67279527
34FOXP1_21924763_ChIP-Seq_HESCs_Human1.64864349
35BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62390999
36MAF_26560356_Chip-Seq_TH2_Human1.61553900
37BCOR_27268052_Chip-Seq_Bcells_Human1.61306377
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58919709
39KDM5A_27292631_Chip-Seq_BREAST_Human1.56758764
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55936134
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.55712398
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55241122
43P53_21459846_ChIP-Seq_SAOS-2_Human1.49954895
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49369069
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49101871
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48537962
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48360037
48RARB_24833708_ChIP-Seq_LIVER_Mouse1.46245374
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45262690
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.44914390
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.44491835
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.42786524
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38944732
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38578914
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38399525
56ELK1_19687146_ChIP-ChIP_HELA_Human1.37798121
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37318588
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.36538446
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32965116
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.31468255
61CTCF_21964334_Chip-Seq_Bcells_Human1.29202388
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28724251
63MAF_26560356_Chip-Seq_TH1_Human1.28661834
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28408904
65PHF8_20622854_ChIP-Seq_HELA_Human1.28257486
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27058307
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26892092
68ERA_21632823_ChIP-Seq_H3396_Human1.26343609
69TTF2_22483619_ChIP-Seq_HELA_Human1.25294194
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24465792
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24141300
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22517139
73CTCF_27219007_Chip-Seq_Bcells_Human1.21566493
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21162182
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17680535
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16611900
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16242676
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16018116
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15041851
80CTCF_20526341_ChIP-Seq_ESCs_Human1.13525803
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13366751
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11653101
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10731692
84P300_27268052_Chip-Seq_Bcells_Human1.10594551
85TAF2_19829295_ChIP-Seq_ESCs_Human1.09993878
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09486963
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08924824
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08657072
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08575337
90ETS1_21867929_ChIP-Seq_TH2_Mouse1.06923973
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05771678
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01326995
93UTX_26944678_Chip-Seq_JUKART_Human1.00789800
94NANOG_20526341_ChIP-Seq_ESCs_Human0.99870566
95ELF5_23300383_ChIP-Seq_T47D_Human0.99631640
96NCOR1_26117541_ChIP-Seq_K562_Human0.98772639
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97281648
98RAC3_21632823_ChIP-Seq_H3396_Human0.97181903
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.96913449
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95466457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.80691387
2MP0005171_absent_coat_pigmentation4.79211428
3MP0001986_abnormal_taste_sensitivity4.64370000
4MP0005174_abnormal_tail_pigmentation3.62463227
5MP0005423_abnormal_somatic_nervous3.47137092
6MP0001188_hyperpigmentation3.35446111
7MP0005083_abnormal_biliary_tract3.06377503
8MP0003806_abnormal_nucleotide_metabolis3.04754276
9MP0001968_abnormal_touch/_nociception2.79936169
10MP0005410_abnormal_fertilization2.59513122
11MP0008875_abnormal_xenobiotic_pharmacok2.19087752
12MP0003123_paternal_imprinting2.11511350
13MP0000750_abnormal_muscle_regeneration2.09788309
14MP0003718_maternal_effect1.89684096
15MP0004147_increased_porphyrin_level1.88688413
16MP0006036_abnormal_mitochondrial_physio1.84543520
17MP0008775_abnormal_heart_ventricle1.83288797
18MP0002138_abnormal_hepatobiliary_system1.74950074
19MP0008058_abnormal_DNA_repair1.72386834
20MP0000751_myopathy1.70562146
21MP0002736_abnormal_nociception_after1.69852305
22MP0005084_abnormal_gallbladder_morpholo1.63743632
23MP0001873_stomach_inflammation1.63695458
24MP0001764_abnormal_homeostasis1.57667340
25MP0003111_abnormal_nucleus_morphology1.50882151
26MP0003693_abnormal_embryo_hatching1.49420348
27MP0010155_abnormal_intestine_physiology1.48670294
28MP0010094_abnormal_chromosome_stability1.47959450
29MP0003453_abnormal_keratinocyte_physiol1.47759607
30MP0001835_abnormal_antigen_presentation1.46496636
31MP0004130_abnormal_muscle_cell1.45587752
32MP0002876_abnormal_thyroid_physiology1.45072374
33MP0005409_darkened_coat_color1.41120292
34MP0000013_abnormal_adipose_tissue1.38439897
35MP0000372_irregular_coat_pigmentation1.37222356
36MP0001502_abnormal_circadian_rhythm1.36673772
37MP0001756_abnormal_urination1.35054254
38MP0005584_abnormal_enzyme/coenzyme_acti1.34926082
39MP0004381_abnormal_hair_follicle1.33698561
40MP0002735_abnormal_chemical_nociception1.27534903
41MP0009278_abnormal_bone_marrow1.27065192
42MP0001545_abnormal_hematopoietic_system1.26127709
43MP0005397_hematopoietic_system_phenotyp1.26127709
44MP0005464_abnormal_platelet_physiology1.21689148
45MP0001191_abnormal_skin_condition1.19753671
46MP0004957_abnormal_blastocyst_morpholog1.19464233
47MP0002148_abnormal_hypersensitivity_rea1.18696071
48MP0002019_abnormal_tumor_incidence1.16342576
49MP0003786_premature_aging1.15949230
50MP0001664_abnormal_digestion1.15731802
51MP0005332_abnormal_amino_acid1.13087383
52MP0002132_abnormal_respiratory_system1.10103613
53MP0003077_abnormal_cell_cycle1.08888426
54MP0001905_abnormal_dopamine_level1.08455940
55MP0000358_abnormal_cell_content/1.07729747
56MP0002837_dystrophic_cardiac_calcinosis1.06523582
57MP0003646_muscle_fatigue1.03711095
58MP0006035_abnormal_mitochondrial_morpho1.00761428
59MP0004043_abnormal_pH_regulation0.97970763
60MP0000681_abnormal_thyroid_gland0.95578326
61MP0000678_abnormal_parathyroid_gland0.94146536
62MP0008007_abnormal_cellular_replicative0.91853258
63MP0000230_abnormal_systemic_arterial0.91350431
64MP0010386_abnormal_urinary_bladder0.89032413
65MP0005387_immune_system_phenotype0.86278281
66MP0001790_abnormal_immune_system0.86278281
67MP0003878_abnormal_ear_physiology0.84576625
68MP0005377_hearing/vestibular/ear_phenot0.84576625
69MP0009333_abnormal_splenocyte_physiolog0.83561356
70MP0002722_abnormal_immune_system0.81764004
71MP0000689_abnormal_spleen_morphology0.79378923
72MP0002160_abnormal_reproductive_system0.77176572
73MP0003763_abnormal_thymus_physiology0.76961236
74MP0000703_abnormal_thymus_morphology0.76912869
75MP0000015_abnormal_ear_pigmentation0.76291327
76MP0003866_abnormal_defecation0.75872949
77MP0001765_abnormal_ion_homeostasis0.74639109
78MP0002429_abnormal_blood_cell0.73892881
79MP0002398_abnormal_bone_marrow0.72061087
80MP0003656_abnormal_erythrocyte_physiolo0.71826950
81MP0008872_abnormal_physiological_respon0.71517568
82MP0000747_muscle_weakness0.70858800
83MP0009780_abnormal_chondrocyte_physiolo0.68623095
84MP0006276_abnormal_autonomic_nervous0.68599540
85MP0004885_abnormal_endolymph0.66896645
86MP0009250_abnormal_appendicular_skeleto0.66553544
87MP0002396_abnormal_hematopoietic_system0.65639766
88MP0000350_abnormal_cell_proliferation0.65422318
89MP0003448_altered_tumor_morphology0.65137084
90MP0008873_increased_physiological_sensi0.65067366
91MP0009697_abnormal_copulation0.64772812
92MP0000613_abnormal_salivary_gland0.64429611
93MP0000313_abnormal_cell_death0.64415813
94MP0002932_abnormal_joint_morphology0.63819762
95MP0008932_abnormal_embryonic_tissue0.59701802
96MP0005551_abnormal_eye_electrophysiolog0.59087576
97MP0001970_abnormal_pain_threshold0.58677901
98MP0000685_abnormal_immune_system0.57697159
99MP0005367_renal/urinary_system_phenotyp0.57616480
100MP0000516_abnormal_urinary_system0.57616480

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.74567997
2Neonatal respiratory distress (HP:0002643)4.51081470
3Abnormality of the costochondral junction (HP:0000919)4.40934571
4Testicular atrophy (HP:0000029)4.35707012
5Thin bony cortex (HP:0002753)4.14680987
6Poikiloderma (HP:0001029)4.04759301
7Abnormality of DNA repair (HP:0003254)4.01119713
8Enlarged epiphyses (HP:0010580)3.96602426
9Brushfield spots (HP:0001088)3.91402509
10Rectal fistula (HP:0100590)3.82658086
11Rectovaginal fistula (HP:0000143)3.82658086
12Abnormality of the intrinsic pathway (HP:0010989)3.74928107
13Attenuation of retinal blood vessels (HP:0007843)3.69576433
14Intestinal fistula (HP:0100819)3.39115733
15Delayed epiphyseal ossification (HP:0002663)3.34440921
16Vaginal fistula (HP:0004320)3.34262098
17Progressive microcephaly (HP:0000253)3.34018826
18Abnormal epiphyseal ossification (HP:0010656)3.28796737
19Increased IgM level (HP:0003496)3.27871426
20Coronal craniosynostosis (HP:0004440)3.19515722
21Absent thumb (HP:0009777)3.18819363
22Epiphyseal stippling (HP:0010655)3.08964417
23Stomatitis (HP:0010280)3.08324485
24Abnormality of the phalanges of the 2nd finger (HP:0009541)3.03821630
25Paralysis (HP:0003470)3.01692522
26Rib fusion (HP:0000902)2.99583068
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.99223026
28Reduced antithrombin III activity (HP:0001976)2.95031698
29Abnormality of alanine metabolism (HP:0010916)2.92970736
30Hyperalaninemia (HP:0003348)2.92970736
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92970736
32Flat occiput (HP:0005469)2.90832539
33Dyschromatopsia (HP:0007641)2.86801387
34Small hand (HP:0200055)2.67385945
35Hypoplasia of the pons (HP:0012110)2.51236187
36Conjunctival hamartoma (HP:0100780)2.50059267
37Hypophosphatemic rickets (HP:0004912)2.47343724
38Hyperlipoproteinemia (HP:0010980)2.45537284
39Short chin (HP:0000331)2.45015072
40Metaphyseal dysplasia (HP:0100255)2.42947566
41Chorioretinal atrophy (HP:0000533)2.42530964
42Hyperinsulinemic hypoglycemia (HP:0000825)2.42515735
43Decreased central vision (HP:0007663)2.39650725
44Anteriorly placed anus (HP:0001545)2.36791372
45Severe muscular hypotonia (HP:0006829)2.33358829
46Squamous cell carcinoma (HP:0002860)2.30890553
473-Methylglutaconic aciduria (HP:0003535)2.29827090
48Facial hemangioma (HP:0000329)2.28800403
49Bony spicule pigmentary retinopathy (HP:0007737)2.27859786
50Aplasia/Hypoplasia of the patella (HP:0006498)2.27517399
51Elevated erythrocyte sedimentation rate (HP:0003565)2.25385266
52Abnormality of the pons (HP:0007361)2.24156188
53Annular pancreas (HP:0001734)2.22843975
54Widely patent fontanelles and sutures (HP:0004492)2.20117734
55Abnormal trabecular bone morphology (HP:0100671)2.17798515
56Birth length less than 3rd percentile (HP:0003561)2.17135677
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17072004
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.12843739
59Abnormal number of erythroid precursors (HP:0012131)2.12253305
60Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.12201491
61Chromsome breakage (HP:0040012)2.11336628
62Patellar aplasia (HP:0006443)2.10731624
63Abnormal drinking behavior (HP:0030082)2.10041000
64Polydipsia (HP:0001959)2.10041000
65Abnormality of the nasal septum (HP:0000419)2.08970243
66Popliteal pterygium (HP:0009756)2.08390025
67Female pseudohermaphroditism (HP:0010458)2.07259802
68Cholelithiasis (HP:0001081)2.05417017
69Abnormal albumin level (HP:0012116)2.05064036
70Hypoalbuminemia (HP:0003073)2.05064036
71Decreased circulating renin level (HP:0003351)2.04588499
72Joint hemorrhage (HP:0005261)2.04561694
73Renal Fanconi syndrome (HP:0001994)2.02366839
74Increased CSF lactate (HP:0002490)2.02115129
75Abnormality of placental membranes (HP:0011409)1.97657226
76Amniotic constriction ring (HP:0009775)1.97657226
77Melanoma (HP:0002861)1.96949297
78Metaphyseal irregularity (HP:0003025)1.94500030
79Increased number of teeth (HP:0011069)1.87501064
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.87320492
81Submucous cleft hard palate (HP:0000176)1.83960909
82Pendular nystagmus (HP:0012043)1.83152824
83Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82477890
84Partial agenesis of the corpus callosum (HP:0001338)1.81379148
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81161307
86Capillary hemangiomas (HP:0005306)1.80281142
87Limb hypertonia (HP:0002509)1.80102852
88Rickets (HP:0002748)1.79897959
89Premature graying of hair (HP:0002216)1.79424136
90Absent/shortened dynein arms (HP:0200106)1.78826976
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.78826976
92Joint stiffness (HP:0001387)1.78496997
93Renal tubular dysfunction (HP:0000124)1.75813278
94Abnormality of cells of the erythroid lineage (HP:0012130)1.75103366
95Akinesia (HP:0002304)1.74991552
96Prolonged partial thromboplastin time (HP:0003645)1.73778667
97Diminished movement (HP:0002374)1.72439838
98Lactic acidosis (HP:0003128)1.71972145
99Death in infancy (HP:0001522)1.70357408
100Hepatic necrosis (HP:0002605)1.68768557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.54771710
2WNK43.89785528
3VRK23.58281606
4CDC73.53155332
5MST43.47726927
6MAPK153.37093784
7TESK23.27045147
8TAOK32.44953247
9CCNB12.36207924
10PDK22.17730703
11ADRBK22.11599661
12PIM22.09326188
13AKT32.06342651
14FLT32.02337734
15TLK11.72826974
16STK161.70005958
17GRK51.61107689
18BCKDK1.59860412
19PRKD31.58481509
20BRAF1.58456523
21ERN11.57948390
22ICK1.50333315
23TEC1.47508546
24ARAF1.36876817
25PHKG21.35204779
26PHKG11.35204779
27SRPK11.33168066
28PKN21.30444648
29ZAK1.24255376
30NEK11.24050327
31VRK11.22909808
32NUAK11.21351695
33BLK1.21084943
34PINK11.18320132
35ADRBK11.14668002
36CDK71.14366551
37MST1R1.10082252
38MUSK1.08889158
39LIMK11.06903805
40LMTK21.06614425
41RIPK40.95738911
42BTK0.94243351
43MAP2K70.93922736
44CSNK1G30.93889335
45CSNK1A1L0.91834957
46EPHA20.90476408
47TESK10.88198905
48GRK60.87749757
49AURKA0.86548358
50DAPK10.84287350
51DAPK20.84021846
52BUB10.80771324
53BMPR1B0.80625627
54WNK10.75890716
55NEK20.73333675
56CHEK20.71438591
57PLK10.69800254
58RPS6KA50.68141901
59TBK10.68079698
60TGFBR10.66676820
61CDK80.63945055
62CSF1R0.63901607
63SYK0.62433668
64DYRK20.58659532
65MAPKAPK50.56761335
66IKBKE0.55498825
67CDK40.54110209
68MAP2K60.53744328
69HIPK20.49845211
70PAK10.49200618
71CSNK1G10.48192619
72MYLK0.47804211
73ATR0.46213037
74CSNK1G20.46194708
75TTK0.45281494
76TAOK20.45228769
77GRK10.44703176
78PRKCI0.43090438
79TXK0.42883429
80ITK0.42410309
81DAPK30.39340325
82AURKB0.38161391
83BCR0.38102987
84PLK30.37375666
85IKBKB0.37364083
86CDK140.37120243
87MKNK10.36610730
88EIF2AK10.35314590
89BMX0.34861300
90IRAK20.32744156
91ZAP700.32456776
92MAP3K110.32231885
93NEK60.31388105
94OXSR10.30518507
95ATM0.29971096
96CHEK10.28443353
97CDK90.27580872
98CDK150.26696011
99CDK11A0.26531512
100CDK180.25831950

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.27098682
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.74399916
3Sulfur metabolism_Homo sapiens_hsa009203.68908752
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.56965908
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.52477275
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.21087277
7Homologous recombination_Homo sapiens_hsa034403.00893869
8Sphingolipid metabolism_Homo sapiens_hsa006002.50913366
9Fatty acid biosynthesis_Homo sapiens_hsa000612.09351741
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98762416
11Nitrogen metabolism_Homo sapiens_hsa009101.95870125
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92941943
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90161816
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86988492
15Nucleotide excision repair_Homo sapiens_hsa034201.80293735
16Basal transcription factors_Homo sapiens_hsa030221.73922592
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66919126
18Ribosome_Homo sapiens_hsa030101.63054841
19Proteasome_Homo sapiens_hsa030501.62234266
20Fructose and mannose metabolism_Homo sapiens_hsa000511.61073200
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59448819
22Fanconi anemia pathway_Homo sapiens_hsa034601.46526816
23Parkinsons disease_Homo sapiens_hsa050121.41570547
24Pyruvate metabolism_Homo sapiens_hsa006201.35160665
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34300410
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33794966
27p53 signaling pathway_Homo sapiens_hsa041151.28909405
28Oxidative phosphorylation_Homo sapiens_hsa001901.27438785
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24749373
30Hedgehog signaling pathway_Homo sapiens_hsa043401.24125202
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19860339
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.19837197
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.19598059
34Base excision repair_Homo sapiens_hsa034101.19527374
35Pyrimidine metabolism_Homo sapiens_hsa002401.15163500
36Huntingtons disease_Homo sapiens_hsa050161.15089765
37Taste transduction_Homo sapiens_hsa047421.14250151
38DNA replication_Homo sapiens_hsa030301.10993944
39Salivary secretion_Homo sapiens_hsa049701.05499088
40Purine metabolism_Homo sapiens_hsa002301.02902274
41Ovarian steroidogenesis_Homo sapiens_hsa049131.01057175
42RNA polymerase_Homo sapiens_hsa030200.99831856
43Non-homologous end-joining_Homo sapiens_hsa034500.98879513
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92181867
45Inositol phosphate metabolism_Homo sapiens_hsa005620.85377556
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83455892
47Morphine addiction_Homo sapiens_hsa050320.82021678
48Alzheimers disease_Homo sapiens_hsa050100.79127501
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73328417
50Asthma_Homo sapiens_hsa053100.72055222
51Metabolic pathways_Homo sapiens_hsa011000.71116029
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70191661
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69451103
54Steroid biosynthesis_Homo sapiens_hsa001000.67638935
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64245128
56African trypanosomiasis_Homo sapiens_hsa051430.63649215
57Calcium signaling pathway_Homo sapiens_hsa040200.61513921
58Mismatch repair_Homo sapiens_hsa034300.61310108
59Selenocompound metabolism_Homo sapiens_hsa004500.61057494
60Peroxisome_Homo sapiens_hsa041460.60779660
61Fatty acid metabolism_Homo sapiens_hsa012120.60284705
62Olfactory transduction_Homo sapiens_hsa047400.55939501
63One carbon pool by folate_Homo sapiens_hsa006700.55208051
64Primary immunodeficiency_Homo sapiens_hsa053400.53540800
65Fat digestion and absorption_Homo sapiens_hsa049750.53348746
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.52162519
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51838631
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50527297
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47695430
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47443747
71Arginine biosynthesis_Homo sapiens_hsa002200.46730647
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.46400008
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45931058
74Biosynthesis of amino acids_Homo sapiens_hsa012300.44668225
75Tryptophan metabolism_Homo sapiens_hsa003800.43237649
76RNA transport_Homo sapiens_hsa030130.42710691
77Propanoate metabolism_Homo sapiens_hsa006400.40861407
78Glycerolipid metabolism_Homo sapiens_hsa005610.40270190
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39541365
80Arachidonic acid metabolism_Homo sapiens_hsa005900.38677959
81RNA degradation_Homo sapiens_hsa030180.38623062
82Cell cycle_Homo sapiens_hsa041100.36361807
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36250784
84Gap junction_Homo sapiens_hsa045400.34652609
85Circadian entrainment_Homo sapiens_hsa047130.33886546
86Cocaine addiction_Homo sapiens_hsa050300.33359757
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31340095
88Thyroid hormone synthesis_Homo sapiens_hsa049180.30842312
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30354285
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29868765
91Glutathione metabolism_Homo sapiens_hsa004800.29483719
92Platelet activation_Homo sapiens_hsa046110.28872563
93Chemical carcinogenesis_Homo sapiens_hsa052040.28705631
94Carbon metabolism_Homo sapiens_hsa012000.27683717
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27600657
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27280989
97Fatty acid elongation_Homo sapiens_hsa000620.27022111
98Nicotine addiction_Homo sapiens_hsa050330.24905573
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.24836792
100Alcoholism_Homo sapiens_hsa050340.23580966

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