EIF2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.13131275
2telomere maintenance via semi-conservative replication (GO:0032201)6.23396770
3nuclear pore complex assembly (GO:0051292)5.95852954
4nuclear pore organization (GO:0006999)5.68492600
5DNA strand elongation involved in DNA replication (GO:0006271)5.45045932
6telomere maintenance via recombination (GO:0000722)5.32284365
7DNA strand elongation (GO:0022616)5.21733769
8negative regulation of transcription by competitive promoter binding (GO:0010944)5.10831591
9DNA replication initiation (GO:0006270)5.06327699
10negative regulation of myotube differentiation (GO:0010832)4.98813757
11* ribosome assembly (GO:0042255)4.90786410
12negative regulation of granulocyte differentiation (GO:0030853)4.80749422
13GDP-mannose metabolic process (GO:0019673)4.70712439
14respiratory chain complex IV assembly (GO:0008535)4.63348896
15mitotic recombination (GO:0006312)4.60909455
16ribosomal small subunit assembly (GO:0000028)4.48929433
17myeloid leukocyte mediated immunity (GO:0002444)4.37019063
18telomere maintenance via telomere lengthening (GO:0010833)4.36617086
19pore complex assembly (GO:0046931)4.23708409
20neutrophil mediated immunity (GO:0002446)4.12929485
21regulation of cellular respiration (GO:0043457)4.07390054
22mitotic sister chromatid cohesion (GO:0007064)3.94743494
23killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.94009133
24disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.94009133
25dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.88051434
26mitotic nuclear envelope disassembly (GO:0007077)3.79357295
27mitotic metaphase plate congression (GO:0007080)3.77755759
28cytochrome complex assembly (GO:0017004)3.73642333
29mannosylation (GO:0097502)3.73573984
30folic acid-containing compound biosynthetic process (GO:0009396)3.72463023
31negative regulation of phagocytosis (GO:0050765)3.72353242
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71103643
33IMP biosynthetic process (GO:0006188)3.64572528
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63134281
35mitochondrion degradation (GO:0000422)3.62854476
36cotranslational protein targeting to membrane (GO:0006613)3.59621823
37DNA replication checkpoint (GO:0000076)3.58283075
38protein targeting to ER (GO:0045047)3.56351329
39negative regulation of growth of symbiont in host (GO:0044130)3.54609604
40negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.54609604
41modulation of growth of symbiont involved in interaction with host (GO:0044144)3.54609604
42regulation of growth of symbiont in host (GO:0044126)3.54609604
43regulation of centriole replication (GO:0046599)3.53906551
44membrane invagination (GO:0010324)3.50221714
45sister chromatid segregation (GO:0000819)3.48776057
46membrane disassembly (GO:0030397)3.48492439
47nuclear envelope disassembly (GO:0051081)3.48492439
48positive regulation of histone H3-K4 methylation (GO:0051571)3.47650525
49mitotic chromosome condensation (GO:0007076)3.46366969
50tongue development (GO:0043586)3.45236469
51cullin deneddylation (GO:0010388)3.43745365
52pseudouridine synthesis (GO:0001522)3.43099844
53protein localization to endoplasmic reticulum (GO:0070972)3.43063823
54viral transcription (GO:0019083)3.42134349
55mitotic G2/M transition checkpoint (GO:0044818)3.40946258
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.40215630
57regulation of translational fidelity (GO:0006450)3.38641094
58proteasome assembly (GO:0043248)3.37567793
59mitotic sister chromatid segregation (GO:0000070)3.37277874
60mitotic G2 DNA damage checkpoint (GO:0007095)3.36855163
61translational termination (GO:0006415)3.35116806
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34575645
63protein localization to kinetochore (GO:0034501)3.34516837
64nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.30485846
65metaphase plate congression (GO:0051310)3.29974460
66establishment of integrated proviral latency (GO:0075713)3.26335184
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25238435
68protein localization to chromosome, centromeric region (GO:0071459)3.22727841
69non-recombinational repair (GO:0000726)3.17016028
70double-strand break repair via nonhomologous end joining (GO:0006303)3.17016028
71signal peptide processing (GO:0006465)3.16881581
72tRNA aminoacylation for protein translation (GO:0006418)3.16830184
73DNA topological change (GO:0006265)3.16013670
74C-terminal protein lipidation (GO:0006501)3.12086710
75synapsis (GO:0007129)3.12059687
76tRNA aminoacylation (GO:0043039)3.11382719
77amino acid activation (GO:0043038)3.11382719
78nucleobase biosynthetic process (GO:0046112)3.10628731
79protein deneddylation (GO:0000338)3.09752657
80mitotic spindle checkpoint (GO:0071174)3.03272109
81positive regulation of protein export from nucleus (GO:0046827)3.03227830
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02823862
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02823862
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.02823862
85telomere maintenance (GO:0000723)3.02816139
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02271960
87translational elongation (GO:0006414)3.02070307
88telomere organization (GO:0032200)3.01084003
89ribosomal large subunit biogenesis (GO:0042273)2.98663702
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96760314
91attachment of spindle microtubules to kinetochore (GO:0008608)2.94895854
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94701271
93DNA replication-dependent nucleosome assembly (GO:0006335)2.93868632
94DNA replication-dependent nucleosome organization (GO:0034723)2.93868632
95purine nucleobase biosynthetic process (GO:0009113)2.93706519
96positive regulation of gluconeogenesis (GO:0045722)2.92788456
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91147201
98establishment of chromosome localization (GO:0051303)2.90400297
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90059261
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90059261
101ribonucleoprotein complex disassembly (GO:0032988)2.89969596
102ribosomal small subunit biogenesis (GO:0042274)2.89896191
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88902049
104formation of translation preinitiation complex (GO:0001731)2.88553627
105killing of cells of other organism (GO:0031640)2.88504008
106disruption of cells of other organism (GO:0044364)2.88504008
107spindle checkpoint (GO:0031577)2.88486816
108nucleobase-containing small molecule interconversion (GO:0015949)2.87576659
109translation (GO:0006412)2.86279349
110maturation of 5.8S rRNA (GO:0000460)2.85935183
111intra-S DNA damage checkpoint (GO:0031573)2.85027534
112maturation of SSU-rRNA (GO:0030490)2.84807619
113kinetochore organization (GO:0051383)2.83506215
114regulation of translational initiation (GO:0006446)2.83494991
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81797933
116regulation of centrosome cycle (GO:0046605)2.81516928
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81383318
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81383318
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81383318
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.81383318
121negative regulation of sister chromatid segregation (GO:0033046)2.81383318
122regulation of translational termination (GO:0006449)2.81098346
123regulation of mitotic sister chromatid separation (GO:0010965)2.80779280
124regulation of mitotic sister chromatid segregation (GO:0033047)2.80779280
125regulation of sister chromatid segregation (GO:0033045)2.80779280
126regulation of chromosome segregation (GO:0051983)2.79829128
127DNA catabolic process, exonucleolytic (GO:0000738)2.79714499
128negative regulation of chromosome segregation (GO:0051985)2.79414993
129positive regulation of chromosome segregation (GO:0051984)2.79378354
130mitotic spindle assembly checkpoint (GO:0007094)2.79171427
131IMP metabolic process (GO:0046040)2.78668453
132organelle disassembly (GO:1903008)2.77816401
133cellular protein complex localization (GO:0034629)2.76419543
134regulation of histone H3-K9 methylation (GO:0051570)2.76108603
135spindle assembly checkpoint (GO:0071173)2.75722163
136chromosome segregation (GO:0007059)2.75539890
137DNA double-strand break processing (GO:0000729)2.75410000
138DNA ligation (GO:0006266)2.74804513
139DNA replication-independent nucleosome organization (GO:0034724)2.74081284
140DNA replication-independent nucleosome assembly (GO:0006336)2.74081284
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73947487
142isotype switching (GO:0045190)2.73947487
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73947487
144response to fungus (GO:0009620)2.71429664
145DNA unwinding involved in DNA replication (GO:0006268)2.70986481
146protein heterotetramerization (GO:0051290)2.70839626
147ribonucleoprotein complex biogenesis (GO:0022613)2.69639800
148defense response to fungus (GO:0050832)2.69232408
149CENP-A containing nucleosome assembly (GO:0034080)2.69215583
150G1/S transition of mitotic cell cycle (GO:0000082)2.68486499
151cell cycle G1/S phase transition (GO:0044843)2.68486499
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.68241918
153regulation of type B pancreatic cell apoptotic process (GO:2000674)2.67371718
154Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66626005
155pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64691738
156regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64650207
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.64384281
158chromatin remodeling at centromere (GO:0031055)2.64024703
159regulation of cellular amino acid metabolic process (GO:0006521)2.62760485
160* translational initiation (GO:0006413)2.62519723
161neutrophil activation involved in immune response (GO:0002283)2.62426923
162response to interferon-beta (GO:0035456)2.62052593
163response to interferon-alpha (GO:0035455)2.61860152
164C-terminal protein amino acid modification (GO:0018410)2.57615477
165rRNA processing (GO:0006364)2.57483458
166regulation of granulocyte differentiation (GO:0030852)2.56976715
167positive regulation of glycoprotein biosynthetic process (GO:0010560)2.55916304
168response to peptidoglycan (GO:0032494)2.54913409
169viral genome replication (GO:0019079)2.54448187
170nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.54121853
171mast cell activation (GO:0045576)2.53882720
172facial nerve structural organization (GO:0021612)2.53471907
173ribosome biogenesis (GO:0042254)2.53192738
174lymphoid progenitor cell differentiation (GO:0002320)2.52833234
175positive regulation of cellular amine metabolic process (GO:0033240)2.52636173
176exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52415320
177generation of neurons (GO:0048699)2.52086209
178negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51936198
179deoxyribonucleotide biosynthetic process (GO:0009263)2.50485950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02276324
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92346985
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.73017690
4EZH2_22144423_ChIP-Seq_EOC_Human3.71588074
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36359077
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34299213
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25060413
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.14061395
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11830441
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84907528
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.81990212
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78579501
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77882480
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71775256
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64346465
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.58246251
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45837346
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42854578
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33108822
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.32205991
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29427984
22* VDR_23849224_ChIP-Seq_CD4+_Human2.27191349
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25558858
24ERG_20887958_ChIP-Seq_HPC-7_Mouse2.22811509
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22670026
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18962396
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12507333
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04631691
29* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02203058
30* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.01770715
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99747869
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98775048
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97731941
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97346193
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95448205
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94564918
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.93936935
38FOXP3_21729870_ChIP-Seq_TREG_Human1.93196598
39SPI1_23547873_ChIP-Seq_NB4_Human1.91412540
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88574632
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.85001646
42XRN2_22483619_ChIP-Seq_HELA_Human1.83552235
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82960754
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81873443
45DCP1A_22483619_ChIP-Seq_HELA_Human1.78437359
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77789941
47VDR_21846776_ChIP-Seq_THP-1_Human1.71146249
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.69864063
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.67814268
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64716071
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64536294
52SCL_19346495_ChIP-Seq_HPC-7_Human1.64281132
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63500544
54GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.63443403
55GABP_19822575_ChIP-Seq_HepG2_Human1.63254042
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62209435
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.60816442
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.60461340
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.59789369
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56831129
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56663278
62MYC_22102868_ChIP-Seq_BL_Human1.56419394
63TTF2_22483619_ChIP-Seq_HELA_Human1.54126767
64GATA1_22025678_ChIP-Seq_K562_Human1.48152906
65IRF1_19129219_ChIP-ChIP_H3396_Human1.46310845
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46183916
67CIITA_25753668_ChIP-Seq_RAJI_Human1.37355490
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36872534
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32018507
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.31629047
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29632550
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29108663
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27369268
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26641469
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25307488
76VDR_24763502_ChIP-Seq_THP-1_Human1.24902116
77KDM5A_27292631_Chip-Seq_BREAST_Human1.24603162
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22056466
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21991377
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21348761
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21034251
82EWS_26573619_Chip-Seq_HEK293_Human1.20595230
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18712806
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17420164
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.16545226
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15345970
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15132633
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14815153
89MYB_26560356_Chip-Seq_TH2_Human1.12600220
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10450887
91IGF1R_20145208_ChIP-Seq_DFB_Human1.10395288
92FUS_26573619_Chip-Seq_HEK293_Human1.08782066
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08054640
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07717590
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07266564
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.07058384
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05954491
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04525094
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02881933
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.01560933
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01329744
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01070920
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00770497
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00286917
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.98508565
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97700634
107MYB_26560356_Chip-Seq_TH1_Human0.96020534
108AR_21909140_ChIP-Seq_LNCAP_Human0.95657427
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95164599
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94471630
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93989530
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92684111
113MYC_18940864_ChIP-ChIP_HL60_Human0.92163289
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92112576
115* ELK1_22589737_ChIP-Seq_MCF10A_Human0.92058595
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91648617
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90979427
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90842593
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90499799
120CHD1_26751641_Chip-Seq_LNCaP_Human0.89283681
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88847728
122TFEB_21752829_ChIP-Seq_HELA_Human0.88501556
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88498439
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87321730
125ELF5_23300383_ChIP-Seq_T47D_Human0.86727977
126PU_27001747_Chip-Seq_BMDM_Mouse0.86271180
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85340992
128MAF_26560356_Chip-Seq_TH1_Human0.84545545
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84181266
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83231508
131VDR_22108803_ChIP-Seq_LS180_Human0.79057128
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77857607
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75174801
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74595102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.72141201
2MP0008260_abnormal_autophagy4.32163918
3MP0003693_abnormal_embryo_hatching3.32151496
4MP0005174_abnormal_tail_pigmentation3.30557727
5MP0003724_increased_susceptibility_to3.21297257
6MP0010234_abnormal_vibrissa_follicle3.16935026
7MP0000015_abnormal_ear_pigmentation2.81274770
8MP0001188_hyperpigmentation2.74354672
9MP0009697_abnormal_copulation2.73813750
10MP0008058_abnormal_DNA_repair2.65201189
11MP0005409_darkened_coat_color2.61946166
12MP0002396_abnormal_hematopoietic_system2.59192825
13MP0010352_gastrointestinal_tract_polyps2.54177972
14MP0010094_abnormal_chromosome_stability2.49939174
15MP0003646_muscle_fatigue2.48248740
16MP0006292_abnormal_olfactory_placode2.29983864
17MP0005075_abnormal_melanosome_morpholog2.29472019
18MP0001835_abnormal_antigen_presentation2.23378842
19MP0001853_heart_inflammation2.20409698
20MP0003436_decreased_susceptibility_to2.20173463
21MP0000490_abnormal_crypts_of2.12645709
22MP0008057_abnormal_DNA_replication2.12246704
23MP0003303_peritoneal_inflammation2.07096147
24MP0003763_abnormal_thymus_physiology2.05233090
25MP0004957_abnormal_blastocyst_morpholog2.04737507
26MP0003111_abnormal_nucleus_morphology2.04544666
27MP0009785_altered_susceptibility_to2.03051599
28MP0000681_abnormal_thyroid_gland2.02503687
29MP0010307_abnormal_tumor_latency2.02270059
30MP0009333_abnormal_splenocyte_physiolog2.00956492
31MP0003941_abnormal_skin_development1.99837140
32MP0003077_abnormal_cell_cycle1.97983083
33MP0002166_altered_tumor_susceptibility1.97501487
34MP0001730_embryonic_growth_arrest1.95245332
35MP0000465_gastrointestinal_hemorrhage1.88676103
36MP0002095_abnormal_skin_pigmentation1.86844305
37MP0003656_abnormal_erythrocyte_physiolo1.84939973
38MP0000350_abnormal_cell_proliferation1.83211932
39MP0002419_abnormal_innate_immunity1.80339464
40MP0002148_abnormal_hypersensitivity_rea1.78855405
41MP0000678_abnormal_parathyroid_gland1.76553256
42MP0005025_abnormal_response_to1.76512685
43MP0005671_abnormal_response_to1.73321379
44MP0003950_abnormal_plasma_membrane1.72393430
45MP0005000_abnormal_immune_tolerance1.72331005
46MP0002876_abnormal_thyroid_physiology1.71981834
47MP0008007_abnormal_cellular_replicative1.71590644
48MP0002006_tumorigenesis1.66060031
49MP0003806_abnormal_nucleotide_metabolis1.64271613
50MP0005380_embryogenesis_phenotype1.61011955
51MP0001672_abnormal_embryogenesis/_devel1.61011955
52MP0002877_abnormal_melanocyte_morpholog1.58211291
53MP0001986_abnormal_taste_sensitivity1.57603710
54MP0003890_abnormal_embryonic-extraembry1.57250009
55MP0001697_abnormal_embryo_size1.56826026
56MP0004782_abnormal_surfactant_physiolog1.52186367
57MP0002420_abnormal_adaptive_immunity1.51786276
58MP0003984_embryonic_growth_retardation1.49924144
59MP0001819_abnormal_immune_cell1.49631322
60MP0003186_abnormal_redox_activity1.49318831
61MP0002398_abnormal_bone_marrow1.47369368
62MP0005464_abnormal_platelet_physiology1.46166334
63MP0002088_abnormal_embryonic_growth/wei1.46018314
64MP0002723_abnormal_immune_serum1.45763027
65MP0000858_altered_metastatic_potential1.44485061
66MP0002086_abnormal_extraembryonic_tissu1.38937514
67MP0000689_abnormal_spleen_morphology1.35404820
68MP0000716_abnormal_immune_system1.34742257
69MP0002796_impaired_skin_barrier1.33489996
70MP0001873_stomach_inflammation1.33321271
71MP0002080_prenatal_lethality1.31602813
72MP0000613_abnormal_salivary_gland1.31307213
73MP0002722_abnormal_immune_system1.26986462
74MP0002452_abnormal_antigen_presenting1.26917957
75MP0000372_irregular_coat_pigmentation1.26611593
76MP0003786_premature_aging1.25236460
77MP0001545_abnormal_hematopoietic_system1.25221186
78MP0005397_hematopoietic_system_phenotyp1.25221186
79MP0002019_abnormal_tumor_incidence1.24212328
80MP0001800_abnormal_humoral_immune1.23275409
81MP0002429_abnormal_blood_cell1.20851150
82MP0001881_abnormal_mammary_gland1.16544303
83MP0005501_abnormal_skin_physiology1.14681977
84MP0003183_abnormal_peptide_metabolism1.12494560
85MP0002084_abnormal_developmental_patter1.12147314
86MP0002751_abnormal_autonomic_nervous1.11304017
87MP0000685_abnormal_immune_system1.09352437
88MP0001845_abnormal_inflammatory_respons1.07695982
89MP0000358_abnormal_cell_content/1.07633444
90MP0004808_abnormal_hematopoietic_stem1.06886388
91MP0010155_abnormal_intestine_physiology1.04994126
92MP0004185_abnormal_adipocyte_glucose1.04066874
93MP0002160_abnormal_reproductive_system1.03730376
94MP0008932_abnormal_embryonic_tissue1.03532525
95MP0005058_abnormal_lysosome_morphology1.03322420
96MP0001661_extended_life_span1.01527925
97MP0001929_abnormal_gametogenesis1.00425704
98MP0010678_abnormal_skin_adnexa0.99936289
99MP0005408_hypopigmentation0.99510967
100MP0002009_preneoplasia0.98481681
101MP0008995_early_reproductive_senescence0.98296799
102MP0001666_abnormal_nutrient_absorption0.98186150
103MP0003868_abnormal_feces_composition0.96933553
104MP0008469_abnormal_protein_level0.94866283
105MP0005076_abnormal_cell_differentiation0.94446438
106MP0003172_abnormal_lysosome_physiology0.93816974
107MP0001533_abnormal_skeleton_physiology0.91757626
108MP0002075_abnormal_coat/hair_pigmentati0.91755196
109MP0008877_abnormal_DNA_methylation0.90792284
110MP0003866_abnormal_defecation0.90504370
111MP0002085_abnormal_embryonic_tissue0.89917417
112MP0002210_abnormal_sex_determination0.89824110
113MP0006036_abnormal_mitochondrial_physio0.89288762
114MP0005451_abnormal_body_composition0.88785081
115MP0006035_abnormal_mitochondrial_morpho0.88568512
116MP0004197_abnormal_fetal_growth/weight/0.88025184
117MP0002139_abnormal_hepatobiliary_system0.87742487
118MP0004264_abnormal_extraembryonic_tissu0.87240203
119MP0002132_abnormal_respiratory_system0.86246274
120MP0000049_abnormal_middle_ear0.86065057
121MP0003221_abnormal_cardiomyocyte_apopto0.85410729
122MP0000343_altered_response_to0.84380654
123MP0001919_abnormal_reproductive_system0.84123462
124MP0001727_abnormal_embryo_implantation0.83440459
125MP0000627_abnormal_mammary_gland0.81751824
126MP0000703_abnormal_thymus_morphology0.81486905
127MP0000371_diluted_coat_color0.81197652
128MP0000313_abnormal_cell_death0.80453299
129MP0003699_abnormal_female_reproductive0.79958167
130MP0002234_abnormal_pharynx_morphology0.79784768
131MP0002693_abnormal_pancreas_physiology0.78267320
132MP0001764_abnormal_homeostasis0.77572625
133MP0001186_pigmentation_phenotype0.77526644
134MP0000598_abnormal_liver_morphology0.77470470
135MP0001270_distended_abdomen0.77373145
136MP0005384_cellular_phenotype0.75237479
137MP0001216_abnormal_epidermal_layer0.75004203
138MP0000653_abnormal_sex_gland0.74687468
139MP0008961_abnormal_basal_metabolism0.74657468
140MP0002060_abnormal_skin_morphology0.74329133
141MP0005621_abnormal_cell_physiology0.74022941
142MP0003943_abnormal_hepatobiliary_system0.72986324
143MP0001145_abnormal_male_reproductive0.72606679
144MP0005389_reproductive_system_phenotype0.72490361
145MP0002405_respiratory_system_inflammati0.72453166
146MP0003879_abnormal_hair_cell0.71861925
147MP0002177_abnormal_outer_ear0.71742114
148MP0002269_muscular_atrophy0.71665114
149MP0003718_maternal_effect0.71178071
150MP0003567_abnormal_fetal_cardiomyocyte0.70745205
151MP0005395_other_phenotype0.69605126
152MP0001502_abnormal_circadian_rhythm0.68158560
153MP0002638_abnormal_pupillary_reflex0.67817547
154MP0006054_spinal_hemorrhage0.66955038
155MP0001191_abnormal_skin_condition0.66160368
156MP0002138_abnormal_hepatobiliary_system0.65436129
157MP0005360_urolithiasis0.63172444
158MP0005266_abnormal_metabolism0.63043597
159MP0001790_abnormal_immune_system0.63034211
160MP0005387_immune_system_phenotype0.63034211
161MP0001119_abnormal_female_reproductive0.62653925
162MP0005332_abnormal_amino_acid0.62565327
163MP0005220_abnormal_exocrine_pancreas0.62128461
164MP0003252_abnormal_bile_duct0.61787654

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)9.25642955
2Type I transferrin isoform profile (HP:0003642)8.53056532
3Abnormal protein N-linked glycosylation (HP:0012347)6.25582077
4Abnormal protein glycosylation (HP:0012346)6.25582077
5Abnormal glycosylation (HP:0012345)6.25582077
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)6.25582077
7Annular pancreas (HP:0001734)3.86837815
8Abnormal number of erythroid precursors (HP:0012131)3.86489637
9Acute myeloid leukemia (HP:0004808)3.81413721
10Abnormality of cells of the erythroid lineage (HP:0012130)3.75715688
11Increased serum pyruvate (HP:0003542)3.72265354
12Abnormality of glycolysis (HP:0004366)3.60059548
13Thoracic kyphosis (HP:0002942)3.55254294
14Thrombocytosis (HP:0001894)3.44429508
15Hypothermia (HP:0002045)3.37902063
16Thyroid-stimulating hormone excess (HP:0002925)3.37264410
17Volvulus (HP:0002580)3.32031203
18Aplastic anemia (HP:0001915)3.31240776
19Abnormality of methionine metabolism (HP:0010901)3.30874262
20Severe visual impairment (HP:0001141)3.16168647
21Abnormality of the intrinsic pathway (HP:0010989)3.07063344
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.04886831
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04406216
24Myelodysplasia (HP:0002863)3.03480219
25Nephroblastoma (Wilms tumor) (HP:0002667)2.96833614
26Elevated erythrocyte sedimentation rate (HP:0003565)2.94658160
27Papillary thyroid carcinoma (HP:0002895)2.93203993
28Hepatic necrosis (HP:0002605)2.86105703
29Increased hepatocellular lipid droplets (HP:0006565)2.85680947
30Multiple enchondromatosis (HP:0005701)2.81991483
31Embryonal renal neoplasm (HP:0011794)2.79746104
32Exertional dyspnea (HP:0002875)2.78535640
33Abnormality of the prostate (HP:0008775)2.77936424
34Ocular albinism (HP:0001107)2.76748438
35Ankle contracture (HP:0006466)2.76490576
36Hepatocellular necrosis (HP:0001404)2.75624279
37Reticulocytopenia (HP:0001896)2.75495863
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73034835
39Abnormality of the thoracic spine (HP:0100711)2.68027922
40Prolonged partial thromboplastin time (HP:0003645)2.67459157
41Progressive external ophthalmoplegia (HP:0000590)2.67329877
42Thyroid carcinoma (HP:0002890)2.61258428
43Obstructive lung disease (HP:0006536)2.60885405
44Chronic obstructive pulmonary disease (HP:0006510)2.60885405
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58490862
46Lipid accumulation in hepatocytes (HP:0006561)2.58178749
47B lymphocytopenia (HP:0010976)2.55339526
48Late onset (HP:0003584)2.54074774
49Rhabdomyosarcoma (HP:0002859)2.53076454
50Capillary hemangiomas (HP:0005306)2.47736990
51Cortical visual impairment (HP:0100704)2.46804051
52Spinal canal stenosis (HP:0003416)2.45041307
53Pancreatic islet-cell hyperplasia (HP:0004510)2.45004516
54Abnormality of magnesium homeostasis (HP:0004921)2.43141724
55IgM deficiency (HP:0002850)2.42560619
56Birth length less than 3rd percentile (HP:0003561)2.38796992
57Gonadotropin excess (HP:0000837)2.37934008
58Renal Fanconi syndrome (HP:0001994)2.35409819
59Recurrent abscess formation (HP:0002722)2.33405466
60Pulmonary fibrosis (HP:0002206)2.32979962
61Microretrognathia (HP:0000308)2.32945070
62Premature ovarian failure (HP:0008209)2.28828938
63Iris hypopigmentation (HP:0007730)2.27415027
64Fatigue (HP:0012378)2.27355414
65Myositis (HP:0100614)2.26407950
66Abnormality of B cell number (HP:0010975)2.25669303
67Autoimmune hemolytic anemia (HP:0001890)2.24639449
68Duodenal stenosis (HP:0100867)2.24338510
69Small intestinal stenosis (HP:0012848)2.24338510
70Exercise-induced muscle cramps (HP:0003710)2.21667560
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19855446
72Ankyloglossia (HP:0010296)2.19464453
73Stomatitis (HP:0010280)2.18700315
74Petechiae (HP:0000967)2.18154167
75Microcytic anemia (HP:0001935)2.16804683
76Sex reversal (HP:0012245)2.16794388
77Abnormal sex determination (HP:0012244)2.16794388
78Meningitis (HP:0001287)2.16753153
79Abnormality of secondary sexual hair (HP:0009888)2.16737866
80Abnormality of the axillary hair (HP:0100134)2.16737866
81Neoplasm of the colon (HP:0100273)2.15610138
82Macrocytic anemia (HP:0001972)2.15049392
83Mediastinal lymphadenopathy (HP:0100721)2.14574602
84Microglossia (HP:0000171)2.13315746
85Abnormality of the renal collecting system (HP:0004742)2.13262310
86Deep philtrum (HP:0002002)2.12693410
87Abnormal lung lobation (HP:0002101)2.11778577
88Increased intramyocellular lipid droplets (HP:0012240)2.11444267
89Acute lymphatic leukemia (HP:0006721)2.10694242
90Pancytopenia (HP:0001876)2.09636480
91Chromsome breakage (HP:0040012)2.08420939
92Limb hypertonia (HP:0002509)2.05733840
93Combined immunodeficiency (HP:0005387)2.04123328
94Abnormality of T cell physiology (HP:0011840)2.03815241
95Agnosia (HP:0010524)2.02834981
96Abnormality of the columella (HP:0009929)2.02116155
97Increased nuchal translucency (HP:0010880)2.01654170
98Microvesicular hepatic steatosis (HP:0001414)2.01492758
99Oral leukoplakia (HP:0002745)1.99256102
100Palpitations (HP:0001962)1.98660263
101Abnormality of sulfur amino acid metabolism (HP:0004339)1.96910517
102Progressive muscle weakness (HP:0003323)1.96241480
103Vacuolated lymphocytes (HP:0001922)1.96052277
104Abnormality of the preputium (HP:0100587)1.95976612
105Cerebral edema (HP:0002181)1.95704862
106Clubbing of toes (HP:0100760)1.95651685
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95439272
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95439272
109Recurrent bacterial skin infections (HP:0005406)1.93788403
110Cutaneous melanoma (HP:0012056)1.93054782
111Lower limb hyperreflexia (HP:0002395)1.93042801
112Hypoglycemic coma (HP:0001325)1.92076773
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91876109
114Short middle phalanx of the 5th finger (HP:0004220)1.91657757
115Abnormal spermatogenesis (HP:0008669)1.91319166
116Cystic hygroma (HP:0000476)1.91091539
117Abnormality of the anterior horn cell (HP:0006802)1.90962945
118Degeneration of anterior horn cells (HP:0002398)1.90962945
119Posterior subcapsular cataract (HP:0007787)1.90495514
120Abnormal rod and cone electroretinograms (HP:0008323)1.90411615
121Megaloblastic anemia (HP:0001889)1.89049637
122Breast carcinoma (HP:0003002)1.88519021
123Neoplasm of the small intestine (HP:0100833)1.88330613
124Stenosis of the external auditory canal (HP:0000402)1.88049897
125Generalized aminoaciduria (HP:0002909)1.87607893
126Meckel diverticulum (HP:0002245)1.87266606
127Cafe-au-lait spot (HP:0000957)1.87086261
128Increased muscle lipid content (HP:0009058)1.86808966
129Knee flexion contracture (HP:0006380)1.86161458
130Neuroblastic tumors (HP:0004376)1.85842182
131Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.85842182
132Neuroblastoma (HP:0003006)1.85842182
133Primitive neuroectodermal tumor (HP:0030065)1.85842182
134Pallor (HP:0000980)1.85431313
135Abnormality of alanine metabolism (HP:0010916)1.85425564
136Hyperalaninemia (HP:0003348)1.85425564
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85425564
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85249124
139Abnormality of chromosome stability (HP:0003220)1.84510566
140Abnormality of serum amino acid levels (HP:0003112)1.83951051
141Biliary tract neoplasm (HP:0100574)1.83541197
142Proximal tubulopathy (HP:0000114)1.83369268
143Central scotoma (HP:0000603)1.82981471
144Respiratory difficulties (HP:0002880)1.82853450
145Ovarian neoplasm (HP:0100615)1.82637104
146Neoplasm of the adrenal gland (HP:0100631)1.81806070
147Eczematoid dermatitis (HP:0000976)1.81519337
148Bone marrow hypocellularity (HP:0005528)1.81216050
149Duplicated collecting system (HP:0000081)1.80939104
150Abnormality of the common coagulation pathway (HP:0010990)1.80845764
151Abnormality of the duodenum (HP:0002246)1.79480565
152Syringomyelia (HP:0003396)1.78219642
153Spinal cord lesions (HP:0100561)1.78219642
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.75250522
155Abnormality of the ileum (HP:0001549)1.75085364
156Dyschromatopsia (HP:0007641)1.74891447
157Premature graying of hair (HP:0002216)1.72428142
158Neoplasm of the rectum (HP:0100743)1.72278678
159Neutropenia (HP:0001875)1.72168869
160Abnormal biliary tract morphology (HP:0012440)1.72110305
161Abnormality of oral frenula (HP:0000190)1.72079528
162Increased serum lactate (HP:0002151)1.72025625
163Abnormal auditory evoked potentials (HP:0006958)1.71112728
164Asymmetry of the thorax (HP:0001555)1.70876282
165Severe combined immunodeficiency (HP:0004430)1.70474737
166Symptomatic seizures (HP:0011145)1.70114341
167Flat occiput (HP:0005469)1.70010964
168Attenuation of retinal blood vessels (HP:0007843)1.69623711
169Granulocytopenia (HP:0001913)1.69480806
170Chest pain (HP:0100749)1.69316581
171Secondary amenorrhea (HP:0000869)1.69017991
172Split foot (HP:0001839)1.68763442
173Poor head control (HP:0002421)1.68030124
174Homocystinuria (HP:0002156)1.67821594
175Abnormality of homocysteine metabolism (HP:0010919)1.67821594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.74767615
2NLK4.62895116
3STK163.94092875
4CAMKK23.47812011
5MST43.08403851
6PBK2.97038358
7MKNK22.91124162
8NEK12.90692044
9WEE12.77285276
10TTK2.76446967
11TEC2.47000552
12TSSK62.42623790
13FES2.23073773
14IRAK42.13971069
15MKNK12.12940012
16KIT1.94014743
17PIM21.87710754
18STK31.85350001
19IRAK31.82629516
20BUB11.80965459
21CDC71.80628440
22ERBB31.73867842
23PLK31.73445420
24NME21.67637782
25VRK11.61970835
26SCYL21.59974617
27FLT31.53276028
28BMPR21.52882870
29TESK21.52879881
30NUAK11.52077690
31EEF2K1.50792319
32TRIM281.43627123
33CDK61.33673997
34ACVR1B1.30118693
35ZAK1.28956116
36LATS11.25786650
37MAP3K131.25779973
38BRD41.25685396
39TGFBR11.25125081
40BTK1.23075503
41YES11.21477340
42MAP3K121.17107858
43SRPK11.15959644
44BMPR1B1.08839660
45PDK21.08378191
46STK391.07558844
47BRSK21.06319053
48EIF2AK11.05135269
49VRK21.04487439
50MUSK1.01689653
51TLK10.93331277
52CDK70.93212632
53PIM10.91792938
54MAP2K30.90300280
55PASK0.90113365
56TAF10.89785343
57TAOK20.89581976
58PLK40.84875787
59MST1R0.84317057
60CHEK10.83505538
61RAF10.83425835
62ATM0.83008150
63CDK40.81943063
64CAMKK10.81800050
65PRPF4B0.81626770
66TESK10.80133771
67KDR0.79189248
68CDK190.79125073
69SYK0.79021246
70TRPM70.77351778
71* EIF2AK30.77257584
72DYRK30.76614433
73ATR0.76065190
74MAP4K10.75591717
75NME10.74479872
76BCR0.74407990
77BCKDK0.74127893
78LYN0.73762205
79CCNB10.73509765
80STK240.73052491
81MET0.72069345
82MAP3K80.71890440
83BRAF0.71254670
84ZAP700.71153219
85MAP4K20.71105096
86RPS6KA40.70013995
87MAP2K70.68362929
88ALK0.67727775
89CAMK10.67491366
90NEK60.66469682
91STK38L0.64482714
92CSNK1G10.64084015
93MAP3K10.64073809
94CSF1R0.60219063
95RPS6KB20.59902440
96GRK60.59387599
97ERN10.59157442
98STK100.58263987
99PLK10.57353734
100CDK90.57014205
101CDK80.56519133
102NEK90.56198512
103DAPK10.54373772
104MELK0.54321208
105NEK20.54164212
106AKT30.54073229
107AURKB0.53129863
108BLK0.52761817
109MAPKAPK30.51885579
110CLK10.50710422
111SIK30.50507072
112IKBKB0.50435206
113KSR20.50052001
114TYK20.49623352
115IKBKE0.48338658
116CAMK40.47639777
117PAK10.47262600
118AURKA0.46777484
119MATK0.46658977
120KSR10.45254078
121UHMK10.44557311
122TAOK30.44423955
123CDK10.43375009
124MAPKAPK50.43057616
125FGFR10.42474179
126* CDK20.42057549
127BRSK10.41821380
128HIPK20.41548210
129CSNK2A10.39439187
130STK40.38073358
131* EIF2AK20.37639462
132CHEK20.37593501
133MAPK40.37452714
134PAK40.37423104
135ADRBK20.37124226
136MAP3K110.36875226
137TXK0.36580481
138ABL20.35508053
139CSNK2A20.35183784
140LCK0.35015029
141JAK30.34284342
142MYLK0.34188956
143LATS20.33578567
144MAP3K20.32943485
145ITK0.32382338
146MAP3K140.31613486
147PRKCI0.31032568
148CSK0.30998413
149CASK0.29725924
150PIK3CG0.29623361
151ERBB40.29443813
152IRAK10.28097374
153RPS6KB10.25376861
154TBK10.22965028

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.79296675
2Mismatch repair_Homo sapiens_hsa034303.75137023
3Ribosome_Homo sapiens_hsa030103.68319939
4Protein export_Homo sapiens_hsa030603.13116856
5Base excision repair_Homo sapiens_hsa034102.89916417
6Homologous recombination_Homo sapiens_hsa034402.82517256
7N-Glycan biosynthesis_Homo sapiens_hsa005102.81429952
8Proteasome_Homo sapiens_hsa030502.69328409
9Propanoate metabolism_Homo sapiens_hsa006402.57932603
10Nucleotide excision repair_Homo sapiens_hsa034202.42919851
11Pyrimidine metabolism_Homo sapiens_hsa002402.39825565
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25554087
13Spliceosome_Homo sapiens_hsa030402.09098869
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04720095
15Other glycan degradation_Homo sapiens_hsa005112.03308040
16RNA polymerase_Homo sapiens_hsa030201.99274500
17Fanconi anemia pathway_Homo sapiens_hsa034601.98394041
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79164954
19Non-homologous end-joining_Homo sapiens_hsa034501.75777085
20One carbon pool by folate_Homo sapiens_hsa006701.74501349
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70209914
22Thyroid cancer_Homo sapiens_hsa052161.67047967
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64807856
24mRNA surveillance pathway_Homo sapiens_hsa030151.64217103
25Cell cycle_Homo sapiens_hsa041101.53930575
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47283807
27Pyruvate metabolism_Homo sapiens_hsa006201.44733193
28Carbon metabolism_Homo sapiens_hsa012001.43494231
29Basal transcription factors_Homo sapiens_hsa030221.39875344
30Purine metabolism_Homo sapiens_hsa002301.39826479
31RNA transport_Homo sapiens_hsa030131.37703987
32p53 signaling pathway_Homo sapiens_hsa041151.37628956
33Renin-angiotensin system_Homo sapiens_hsa046141.36896206
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35052291
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28887852
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24937873
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24679880
38Pentose phosphate pathway_Homo sapiens_hsa000301.24514754
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22803428
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20954403
41RNA degradation_Homo sapiens_hsa030181.20534425
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16105481
43Folate biosynthesis_Homo sapiens_hsa007901.08679218
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02500808
45Leishmaniasis_Homo sapiens_hsa051401.01948901
46Systemic lupus erythematosus_Homo sapiens_hsa053221.01513251
47Oocyte meiosis_Homo sapiens_hsa041141.01110459
48Herpes simplex infection_Homo sapiens_hsa051681.00204175
49Primary immunodeficiency_Homo sapiens_hsa053400.98069764
50Fatty acid elongation_Homo sapiens_hsa000620.93817405
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93199291
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92167911
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.91106864
54Steroid biosynthesis_Homo sapiens_hsa001000.90219404
55Regulation of autophagy_Homo sapiens_hsa041400.89425430
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87977512
57Selenocompound metabolism_Homo sapiens_hsa004500.87027254
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86790539
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.85724342
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85261977
61Circadian rhythm_Homo sapiens_hsa047100.85205905
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81526430
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.81280982
64Measles_Homo sapiens_hsa051620.79711617
65Sulfur metabolism_Homo sapiens_hsa009200.79154574
66Vitamin B6 metabolism_Homo sapiens_hsa007500.78093602
67Glutathione metabolism_Homo sapiens_hsa004800.77319049
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76026091
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.70034430
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.67790474
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67683681
72Antigen processing and presentation_Homo sapiens_hsa046120.66408295
73Legionellosis_Homo sapiens_hsa051340.63624901
74Asthma_Homo sapiens_hsa053100.62905145
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62571575
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62100993
77Caffeine metabolism_Homo sapiens_hsa002320.62021262
78Epstein-Barr virus infection_Homo sapiens_hsa051690.60424971
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60045794
80Galactose metabolism_Homo sapiens_hsa000520.58839177
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58115951
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57806802
83Oxidative phosphorylation_Homo sapiens_hsa001900.55513754
84Sulfur relay system_Homo sapiens_hsa041220.54266240
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53679992
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52471642
87Hematopoietic cell lineage_Homo sapiens_hsa046400.50838047
88Fatty acid metabolism_Homo sapiens_hsa012120.50816508
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49107120
90Chronic myeloid leukemia_Homo sapiens_hsa052200.48797200
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48274845
92Acute myeloid leukemia_Homo sapiens_hsa052210.48262818
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.47131684
94Metabolic pathways_Homo sapiens_hsa011000.46615717
95Pertussis_Homo sapiens_hsa051330.46446077
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46055313
97Pancreatic cancer_Homo sapiens_hsa052120.44119741
98Lysine degradation_Homo sapiens_hsa003100.43267185
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42941391
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42845373
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.41225353
102Arachidonic acid metabolism_Homo sapiens_hsa005900.41196704
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40778386
104Sphingolipid metabolism_Homo sapiens_hsa006000.40071108
105TGF-beta signaling pathway_Homo sapiens_hsa043500.39471308
106Apoptosis_Homo sapiens_hsa042100.37144163
107Allograft rejection_Homo sapiens_hsa053300.37115719
108Malaria_Homo sapiens_hsa051440.36894938
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36451329
110Hepatitis B_Homo sapiens_hsa051610.36424696
111Influenza A_Homo sapiens_hsa051640.35857419
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.35760215
113Osteoclast differentiation_Homo sapiens_hsa043800.35146228
114Vitamin digestion and absorption_Homo sapiens_hsa049770.34396228
115Small cell lung cancer_Homo sapiens_hsa052220.34034217
116Viral carcinogenesis_Homo sapiens_hsa052030.33511802
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33110897
118Lysosome_Homo sapiens_hsa041420.32722037
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32465724
120Tuberculosis_Homo sapiens_hsa051520.31921477
121Phagosome_Homo sapiens_hsa041450.31872767
122HTLV-I infection_Homo sapiens_hsa051660.31872701
123Biosynthesis of amino acids_Homo sapiens_hsa012300.30943114
124Peroxisome_Homo sapiens_hsa041460.30400904
125Fatty acid degradation_Homo sapiens_hsa000710.28010200
126Parkinsons disease_Homo sapiens_hsa050120.27272224
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.26869229
128Starch and sucrose metabolism_Homo sapiens_hsa005000.26651192
129Prostate cancer_Homo sapiens_hsa052150.26538647
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.26116360
131Salmonella infection_Homo sapiens_hsa051320.26007977
132Huntingtons disease_Homo sapiens_hsa050160.24431043
133Shigellosis_Homo sapiens_hsa051310.24414093
134Type I diabetes mellitus_Homo sapiens_hsa049400.24191553
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23722316
136MicroRNAs in cancer_Homo sapiens_hsa052060.22512108
137Arginine biosynthesis_Homo sapiens_hsa002200.19764379
138Butanoate metabolism_Homo sapiens_hsa006500.17982530

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