EIF2AK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.39918802
2porphyrin-containing compound biosynthetic process (GO:0006779)7.63477608
3heme biosynthetic process (GO:0006783)7.30733076
4tetrapyrrole biosynthetic process (GO:0033014)6.77273554
5* porphyrin-containing compound metabolic process (GO:0006778)6.09596354
6heme metabolic process (GO:0042168)5.90088309
7oxygen transport (GO:0015671)5.26664988
8erythrocyte maturation (GO:0043249)5.19486219
9Golgi transport vesicle coating (GO:0048200)5.11116566
10COPI coating of Golgi vesicle (GO:0048205)5.11116566
11gas transport (GO:0015669)4.87362259
12nuclear pore complex assembly (GO:0051292)4.76675937
13regulation of RNA export from nucleus (GO:0046831)4.69197259
14proline biosynthetic process (GO:0006561)4.61496660
15regulation of translational fidelity (GO:0006450)4.48448278
16response to methylmercury (GO:0051597)4.48393995
17hemoglobin metabolic process (GO:0020027)4.41057411
18response to lead ion (GO:0010288)4.37497457
19negative regulation of erythrocyte differentiation (GO:0045647)4.16568937
20erythrocyte development (GO:0048821)4.14437157
21cysteine metabolic process (GO:0006534)4.12774850
22regulation of nucleobase-containing compound transport (GO:0032239)4.04229129
23folic acid-containing compound biosynthetic process (GO:0009396)4.03780338
24* tetrapyrrole metabolic process (GO:0033013)3.95321954
25protein localization to kinetochore (GO:0034501)3.82143507
26DNA topological change (GO:0006265)3.78925145
27nuclear pore organization (GO:0006999)3.77603203
28lysine metabolic process (GO:0006553)3.76305101
29lysine catabolic process (GO:0006554)3.76305101
30protein localization to chromosome, centromeric region (GO:0071459)3.72691136
31response to insecticide (GO:0017085)3.72155612
32regulation of histone H3-K27 methylation (GO:0061085)3.66558395
33mitotic chromosome condensation (GO:0007076)3.64519356
34DNA unwinding involved in DNA replication (GO:0006268)3.59731218
35DNA replication checkpoint (GO:0000076)3.56477997
36pigment biosynthetic process (GO:0046148)3.51635688
37glycine metabolic process (GO:0006544)3.50500026
38iron ion import (GO:0097286)3.48871785
39DNA strand elongation involved in DNA replication (GO:0006271)3.42510125
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42083126
41modulation by virus of host process (GO:0019054)3.40890510
42mitotic sister chromatid segregation (GO:0000070)3.40066326
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.37538127
44pore complex assembly (GO:0046931)3.37535239
45regulation of response to osmotic stress (GO:0047484)3.34635997
46protein export from nucleus (GO:0006611)3.34199250
47mitotic metaphase plate congression (GO:0007080)3.30743402
48glucose 6-phosphate metabolic process (GO:0051156)3.23133008
49DNA strand elongation (GO:0022616)3.22991594
50definitive hemopoiesis (GO:0060216)3.21279031
51telomere maintenance via semi-conservative replication (GO:0032201)3.18741766
52very-low-density lipoprotein particle assembly (GO:0034379)3.18264629
53sister chromatid segregation (GO:0000819)3.17657858
54protein retention in ER lumen (GO:0006621)3.16382907
55mitotic nuclear envelope disassembly (GO:0007077)3.15450196
56regulation of early endosome to late endosome transport (GO:2000641)3.15351735
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14452984
58serine family amino acid metabolic process (GO:0009069)3.14111108
59poly(A)+ mRNA export from nucleus (GO:0016973)3.13675635
60response to arsenic-containing substance (GO:0046685)3.13187236
61translesion synthesis (GO:0019985)3.11243704
62proline metabolic process (GO:0006560)3.10568179
633-UTR-mediated mRNA stabilization (GO:0070935)3.10499194
64pigment metabolic process (GO:0042440)3.05717129
65one-carbon metabolic process (GO:0006730)3.03108945
66mRNA stabilization (GO:0048255)3.01858869
67RNA stabilization (GO:0043489)3.01858869
68positive regulation of DNA-dependent DNA replication (GO:2000105)3.00452654
69kinetochore organization (GO:0051383)2.99396024
70modulation by symbiont of host cellular process (GO:0044068)2.99044687
71plasma lipoprotein particle assembly (GO:0034377)2.95793721
72negative regulation of histone methylation (GO:0031061)2.95275284
73nuclear envelope disassembly (GO:0051081)2.94548376
74membrane disassembly (GO:0030397)2.94548376
75glucose catabolic process (GO:0006007)2.92708263
76protein-lipid complex assembly (GO:0065005)2.90870855
77serine family amino acid biosynthetic process (GO:0009070)2.90499488
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89303897
79erythrocyte differentiation (GO:0030218)2.87682410
80attachment of spindle microtubules to kinetochore (GO:0008608)2.86256580
81regulation of chromatin binding (GO:0035561)2.85545441
82vesicle coating (GO:0006901)2.84937615
83pentose-phosphate shunt (GO:0006098)2.84580111
84L-alpha-amino acid transmembrane transport (GO:1902475)2.83152698
85regulation of histone H3-K4 methylation (GO:0051569)2.82909422
86modulation by virus of host morphology or physiology (GO:0019048)2.82680685
87megakaryocyte development (GO:0035855)2.82554813
88negative regulation of fatty acid biosynthetic process (GO:0045717)2.82246314
89regulation of spindle organization (GO:0090224)2.81754520
90regulation of cytokine secretion involved in immune response (GO:0002739)2.81237054
91IMP biosynthetic process (GO:0006188)2.80120121
92formation of translation preinitiation complex (GO:0001731)2.80077108
93DNA replication initiation (GO:0006270)2.78228852
94receptor recycling (GO:0001881)2.77278646
95folic acid metabolic process (GO:0046655)2.77169820
96positive regulation of nuclease activity (GO:0032075)2.76615274
97nucleobase-containing small molecule interconversion (GO:0015949)2.75895154
98pteridine-containing compound biosynthetic process (GO:0042559)2.75591050
99chromosome condensation (GO:0030261)2.73945127
100metaphase plate congression (GO:0051310)2.73904606
101nucleosome disassembly (GO:0006337)2.73636836
102protein-DNA complex disassembly (GO:0032986)2.73636836
103actin filament capping (GO:0051693)2.73035304
104activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72529690
105IMP metabolic process (GO:0046040)2.72051862
106negative regulation of protein localization to plasma membrane (GO:1903077)2.72047722
107telomere maintenance via recombination (GO:0000722)2.71564233
108cellular response to virus (GO:0098586)2.70551179
109negative regulation of viral entry into host cell (GO:0046597)2.69375529
110regulation of mitotic spindle organization (GO:0060236)2.69156910
111purine-containing compound salvage (GO:0043101)2.68922230
112cofactor biosynthetic process (GO:0051188)2.68548133
113granulocyte differentiation (GO:0030851)2.67079686
114myeloid cell development (GO:0061515)2.66728048
115hepatocyte apoptotic process (GO:0097284)2.63981664
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63946303
117L-phenylalanine metabolic process (GO:0006558)2.63946303
118heterochromatin organization (GO:0070828)2.62631420
119mitotic recombination (GO:0006312)2.62374688
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.61593598
121tetrahydrofolate metabolic process (GO:0046653)2.61592866
122glucocorticoid receptor signaling pathway (GO:0042921)2.61185312
123citrulline biosynthetic process (GO:0019240)2.61060380
124regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60802696
125platelet formation (GO:0030220)2.59036373
126serine family amino acid catabolic process (GO:0009071)2.58172748
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.54185275
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53861943
129CENP-A containing nucleosome assembly (GO:0034080)2.51519802
130NADPH regeneration (GO:0006740)2.51028221
131endoplasmic reticulum unfolded protein response (GO:0030968)2.50938712
132establishment of chromosome localization (GO:0051303)2.50361889
133postreplication repair (GO:0006301)2.50089315
134urea cycle (GO:0000050)2.49172132
135urea metabolic process (GO:0019627)2.49172132
136kinetochore assembly (GO:0051382)2.48652072
137heme transport (GO:0015886)2.48054353
138positive regulation of chromosome segregation (GO:0051984)2.47577816
139amino-acid betaine metabolic process (GO:0006577)2.47407316
1402-oxoglutarate metabolic process (GO:0006103)2.47326363
141ribosomal small subunit biogenesis (GO:0042274)2.47325394
142regulation of respiratory burst (GO:0060263)2.47184440
143histone H2B ubiquitination (GO:0033523)2.47173259
144regulation of DNA endoreduplication (GO:0032875)2.46085156
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45669649
146ER-nucleus signaling pathway (GO:0006984)2.44890646
147protein maturation by protein folding (GO:0022417)2.44668483
148regulation of nuclease activity (GO:0032069)2.43946792
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.43900097
150negative regulation of RNA splicing (GO:0033119)2.43856512
151aspartate family amino acid catabolic process (GO:0009068)2.43318886
152chromatin remodeling at centromere (GO:0031055)2.42411268
153glutamate metabolic process (GO:0006536)2.42406480
154nucleoside salvage (GO:0043174)2.41918193
155negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41675282
156protein localization to chromosome (GO:0034502)2.41016413
157purine nucleotide salvage (GO:0032261)2.40757151
158mitochondrial RNA metabolic process (GO:0000959)2.40619008
159positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.40157131
160protein carboxylation (GO:0018214)2.39904131
161peptidyl-glutamic acid carboxylation (GO:0017187)2.39904131
162dosage compensation (GO:0007549)2.38498448
163chromatin assembly or disassembly (GO:0006333)2.37887992
164killing of cells of other organism (GO:0031640)2.37620195
165* protoporphyrinogen IX metabolic process (GO:0046501)10.6688621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84793104
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.08814481
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.82145777
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18061610
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90198526
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79601313
7GATA1_22025678_ChIP-Seq_K562_Human2.78962212
8MYC_22102868_ChIP-Seq_BL_Human2.78110580
9ZNF263_19887448_ChIP-Seq_K562_Human2.71045574
10TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.39743207
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.33852940
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.27926468
13* GATA1_19941827_ChIP-Seq_MEL_Mouse2.13707014
14GATA1_19941826_ChIP-Seq_K562_Human2.10773686
15VDR_21846776_ChIP-Seq_THP-1_Human2.04916000
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01629819
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.94714298
18AR_21909140_ChIP-Seq_LNCAP_Human1.83117235
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82953035
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81772003
21* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76937206
22CIITA_25753668_ChIP-Seq_RAJI_Human1.72261666
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72057998
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71953432
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71594962
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70414017
27XRN2_22483619_ChIP-Seq_HELA_Human1.67030260
28* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66799895
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64689465
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64228935
31RACK7_27058665_Chip-Seq_MCF-7_Human1.63189642
32SCL_19346495_ChIP-Seq_HPC-7_Human1.61514079
33CLOCK_20551151_ChIP-Seq_293T_Human1.60194195
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.55094734
35* E2F1_21310950_ChIP-Seq_MCF-7_Human1.51927412
36* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50705670
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50314693
38FOXP3_21729870_ChIP-Seq_TREG_Human1.50123828
39MAF_26560356_Chip-Seq_TH1_Human1.47683759
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47592190
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46693258
42LXR_22292898_ChIP-Seq_THP-1_Human1.42349913
43UTX_26944678_Chip-Seq_JUKART_Human1.42218470
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40573826
45DCP1A_22483619_ChIP-Seq_HELA_Human1.38744042
46KDM5A_27292631_Chip-Seq_BREAST_Human1.38480790
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38069047
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35578221
49* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.34079595
50CHD1_26751641_Chip-Seq_LNCaP_Human1.33870877
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32480423
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32422624
53TCF7_22412390_ChIP-Seq_EML_Mouse1.30553345
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30081898
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30019924
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29448444
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28131005
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28084910
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27470601
60VDR_23849224_ChIP-Seq_CD4+_Human1.26723715
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25800798
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24737154
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.24372584
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24179942
65GABP_19822575_ChIP-Seq_HepG2_Human1.23862540
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23382365
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23021300
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22612533
69ATF3_27146783_Chip-Seq_COLON_Human1.21801462
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21676107
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20482634
72TFEB_21752829_ChIP-Seq_HELA_Human1.20340750
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.20182934
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19556095
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18428049
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.17492680
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17427818
78GATA2_19941826_ChIP-Seq_K562_Human1.16388715
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16362272
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15629173
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14778720
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13880233
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13181790
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.12491285
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12193904
86* KDM2B_26808549_Chip-Seq_DND41_Human1.11680553
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11554790
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11452343
89* NCOR1_26117541_ChIP-Seq_K562_Human1.11292287
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10188209
91MAF_26560356_Chip-Seq_TH2_Human1.10055407
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08821220
93MYB_26560356_Chip-Seq_TH1_Human1.08765828
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08644633
95VDR_24763502_ChIP-Seq_THP-1_Human1.08539201
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08501928
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07699658
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05504840
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05326221
100* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05112579
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05105718
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03896344
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03376161
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03062892
105MYB_26560356_Chip-Seq_TH2_Human1.02835092
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02834771
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02786002
108KDM2B_26808549_Chip-Seq_K562_Human1.01932466
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01507759
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01493012
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01427513
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.01383427
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00666455
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99185805
115* ELF1_20517297_ChIP-Seq_JURKAT_Human0.98993795
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.98735783
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98455153
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98261879
119GATA6_25053715_ChIP-Seq_YYC3_Human0.97581173
120TTF2_22483619_ChIP-Seq_HELA_Human0.97551809
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96514959
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96198970
123CREB1_26743006_Chip-Seq_LNCaP_Human0.95653421
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94948148
125SPI1_23547873_ChIP-Seq_NB4_Human0.94941344
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94865022
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94786968
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94723868
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94379547
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.93117291
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90252315
132P68_20966046_ChIP-Seq_HELA_Human0.90115080
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89040946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003656_abnormal_erythrocyte_physiolo7.10184093
2MP0004147_increased_porphyrin_level5.41784033
3MP0002139_abnormal_hepatobiliary_system4.12989229
4MP0005360_urolithiasis4.09501775
5MP0005451_abnormal_body_composition3.47007219
6MP0009840_abnormal_foam_cell3.44776425
7MP0003111_abnormal_nucleus_morphology2.99945345
8MP0005083_abnormal_biliary_tract2.68514652
9MP0002877_abnormal_melanocyte_morpholog2.58985103
10MP0010094_abnormal_chromosome_stability2.44352618
11MP0005085_abnormal_gallbladder_physiolo2.40057154
12MP0003303_peritoneal_inflammation2.33363643
13MP0003693_abnormal_embryo_hatching2.32319814
14MP0003566_abnormal_cell_adhesion2.25494010
15MP0003077_abnormal_cell_cycle2.23555250
16MP0005365_abnormal_bile_salt2.23051361
17MP0004264_abnormal_extraembryonic_tissu2.20768831
18MP0008260_abnormal_autophagy2.18007625
19MP0003806_abnormal_nucleotide_metabolis2.09834687
20MP0003300_gastrointestinal_ulcer2.01657283
21MP0005501_abnormal_skin_physiology1.88794335
22MP0004233_abnormal_muscle_weight1.88491680
23MP0005058_abnormal_lysosome_morphology1.87990965
24MP0010307_abnormal_tumor_latency1.85807144
25MP0005397_hematopoietic_system_phenotyp1.74008430
26MP0001545_abnormal_hematopoietic_system1.74008430
27MP0002396_abnormal_hematopoietic_system1.73603676
28MP0004957_abnormal_blastocyst_morpholog1.72400584
29MP0000490_abnormal_crypts_of1.70710287
30MP0010234_abnormal_vibrissa_follicle1.66849303
31MP0005409_darkened_coat_color1.63822630
32MP0010329_abnormal_lipoprotein_level1.62942903
33MP0002398_abnormal_bone_marrow1.60320926
34MP0008057_abnormal_DNA_replication1.54067909
35MP0000609_abnormal_liver_physiology1.50325370
36MP0003172_abnormal_lysosome_physiology1.49510723
37MP0008875_abnormal_xenobiotic_pharmacok1.47188645
38MP0002132_abnormal_respiratory_system1.46544746
39* MP0005636_abnormal_mineral_homeostasis1.46292155
40MP0000689_abnormal_spleen_morphology1.46181616
41MP0005464_abnormal_platelet_physiology1.43230777
42MP0009278_abnormal_bone_marrow1.43130632
43MP0006036_abnormal_mitochondrial_physio1.42060396
44MP0003453_abnormal_keratinocyte_physiol1.41502059
45MP0002086_abnormal_extraembryonic_tissu1.40991768
46MP0002722_abnormal_immune_system1.40528920
47MP0005408_hypopigmentation1.38265087
48MP0002009_preneoplasia1.36184732
49MP0003252_abnormal_bile_duct1.34305277
50MP0002088_abnormal_embryonic_growth/wei1.30966098
51MP0000678_abnormal_parathyroid_gland1.30171360
52MP0000350_abnormal_cell_proliferation1.29050243
53MP0001730_embryonic_growth_arrest1.28771457
54MP0005319_abnormal_enzyme/_coenzyme1.25725321
55MP0001915_intracranial_hemorrhage1.25718217
56MP0005621_abnormal_cell_physiology1.25030242
57MP0003191_abnormal_cellular_cholesterol1.24366752
58MP0005332_abnormal_amino_acid1.24067962
59* MP0002429_abnormal_blood_cell1.22740568
60MP0001666_abnormal_nutrient_absorption1.22681232
61MP0005584_abnormal_enzyme/coenzyme_acti1.22657511
62MP0003705_abnormal_hypodermis_morpholog1.22382772
63MP0005666_abnormal_adipose_tissue1.21381796
64MP0003183_abnormal_peptide_metabolism1.20858316
65MP0000598_abnormal_liver_morphology1.18639367
66MP0003186_abnormal_redox_activity1.17753786
67MP0002796_impaired_skin_barrier1.13780508
68MP0005384_cellular_phenotype1.10822692
69MP0002019_abnormal_tumor_incidence1.10386287
70MP0001849_ear_inflammation1.10255153
71MP0003436_decreased_susceptibility_to1.09337846
72MP0000703_abnormal_thymus_morphology1.06659368
73MP0000313_abnormal_cell_death1.06098769
74MP0009643_abnormal_urine_homeostasis1.05598729
75MP0002166_altered_tumor_susceptibility1.05418842
76MP0003868_abnormal_feces_composition1.05053072
77MP0001800_abnormal_humoral_immune1.05024546
78MP0008007_abnormal_cellular_replicative1.03966552
79MP0009333_abnormal_splenocyte_physiolog1.01128733
80MP0000716_abnormal_immune_system1.00119443
81MP0002102_abnormal_ear_morphology0.99885968
82MP0002138_abnormal_hepatobiliary_system0.99775105
83MP0005671_abnormal_response_to0.97912770
84MP0003123_paternal_imprinting0.97089727
85MP0005076_abnormal_cell_differentiation0.95856433
86MP0002080_prenatal_lethality0.94909960
87MP0010352_gastrointestinal_tract_polyps0.94633215
88MP0009764_decreased_sensitivity_to0.94627146
89MP0009053_abnormal_anal_canal0.93004186
90MP0001663_abnormal_digestive_system0.91892592
91MP0004858_abnormal_nervous_system0.91406249
92MP0001881_abnormal_mammary_gland0.91324330
93MP0000685_abnormal_immune_system0.90662828
94MP0000358_abnormal_cell_content/0.90515276
95MP0009672_abnormal_birth_weight0.90200128
96MP0000858_altered_metastatic_potential0.90134370
97MP0009763_increased_sensitivity_to0.89652540
98MP0004808_abnormal_hematopoietic_stem0.88539040
99MP0003646_muscle_fatigue0.88084173
100MP0001348_abnormal_lacrimal_gland0.87651393
101MP0009697_abnormal_copulation0.87006365
102MP0004185_abnormal_adipocyte_glucose0.86784273
103MP0001835_abnormal_antigen_presentation0.86739991
104MP0008058_abnormal_DNA_repair0.85373262
105MP0002089_abnormal_postnatal_growth/wei0.85086936
106MP0001756_abnormal_urination0.84770131
107MP0002452_abnormal_antigen_presenting0.84234112
108MP0002420_abnormal_adaptive_immunity0.83908400
109MP0000377_abnormal_hair_follicle0.83043455
110MP0001819_abnormal_immune_cell0.82955850
111MP0003221_abnormal_cardiomyocyte_apopto0.82522243
112MP0002084_abnormal_developmental_patter0.82253119
113MP0008932_abnormal_embryonic_tissue0.81438928
114MP0002118_abnormal_lipid_homeostasis0.81397985
115MP0002085_abnormal_embryonic_tissue0.81076894
116MP0001697_abnormal_embryo_size0.80475424
117MP0004130_abnormal_muscle_cell0.79751774
118MP0001661_extended_life_span0.79026408
119MP0005025_abnormal_response_to0.78058937
120MP0004197_abnormal_fetal_growth/weight/0.77116032
121MP0004947_skin_inflammation0.76916186
122MP0005000_abnormal_immune_tolerance0.76550350
123MP0004859_abnormal_synaptic_plasticity0.76279227
124MP0008872_abnormal_physiological_respon0.76050501
125MP0008469_abnormal_protein_level0.75637312
126MP0006035_abnormal_mitochondrial_morpho0.74919529
127MP0006054_spinal_hemorrhage0.74670877
128MP0001672_abnormal_embryogenesis/_devel0.74517709
129MP0005380_embryogenesis_phenotype0.74517709
130MP0008961_abnormal_basal_metabolism0.74388084
131MP0003943_abnormal_hepatobiliary_system0.73931199
132MP0002970_abnormal_white_adipose0.73750889
133MP0002136_abnormal_kidney_physiology0.73482825
134MP0002653_abnormal_ependyma_morphology0.71361739
135MP0009765_abnormal_xenobiotic_induced0.70750182
136MP0002723_abnormal_immune_serum0.70658259
137MP0000627_abnormal_mammary_gland0.70051153
138MP0008770_decreased_survivor_rate0.69783818
139MP0010630_abnormal_cardiac_muscle0.69548975
140MP0001764_abnormal_homeostasis0.69379360
141MP0009931_abnormal_skin_appearance0.69367350
142MP0003984_embryonic_growth_retardation0.69243529
143MP0001216_abnormal_epidermal_layer0.68792158
144MP0005387_immune_system_phenotype0.68707196
145MP0001790_abnormal_immune_system0.68707196
146MP0001873_stomach_inflammation0.68656257
147MP0002060_abnormal_skin_morphology0.68521283
148MP0005375_adipose_tissue_phenotype0.67503984
149MP0002098_abnormal_vibrissa_morphology0.65093956
150MP0009703_decreased_birth_body0.64326161

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.70130068
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.51328859
3Acanthocytosis (HP:0001927)6.54845078
4Reticulocytosis (HP:0001923)5.67437565
5Hypochromic microcytic anemia (HP:0004840)5.28957436
6Cholelithiasis (HP:0001081)4.97403480
7Hyperbilirubinemia (HP:0002904)4.70143400
8Abnormal gallbladder morphology (HP:0012437)4.41692223
9Abnormality of reticulocytes (HP:0004312)4.09960413
10Menorrhagia (HP:0000132)3.88542679
11Abnormal gallbladder physiology (HP:0012438)3.62145866
12Cholecystitis (HP:0001082)3.62145866
13Abnormal hemoglobin (HP:0011902)3.45963611
14Abnormality of the gallbladder (HP:0005264)3.38406288
15Paralysis (HP:0003470)3.34508389
16Hypochromic anemia (HP:0001931)3.18721573
17Microcytic anemia (HP:0001935)3.12676597
18Deep venous thrombosis (HP:0002625)3.07820245
19Insomnia (HP:0100785)3.00478849
20Purpura (HP:0000979)3.00277487
21Ileus (HP:0002595)2.99340210
22Hyperthyroidism (HP:0000836)2.90491291
23Diaphragmatic weakness (HP:0009113)2.82738993
24Orthostatic hypotension (HP:0001278)2.73153289
25Ankyloglossia (HP:0010296)2.70110785
26Global brain atrophy (HP:0002283)2.67758734
27Hyperacusis (HP:0010780)2.60076366
28Gingival bleeding (HP:0000225)2.59987029
29Truncus arteriosus (HP:0001660)2.58507889
30Flat acetabular roof (HP:0003180)2.56718864
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55827613
32Increased serum ferritin (HP:0003281)2.48202284
33Hypoparathyroidism (HP:0000829)2.46610117
34Polycythemia (HP:0001901)2.43628664
35Cutaneous photosensitivity (HP:0000992)2.41171013
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40455147
37Seborrheic dermatitis (HP:0001051)2.39027284
38Abnormality of the common coagulation pathway (HP:0010990)2.38450151
39Hepatocellular carcinoma (HP:0001402)2.38208867
40Insidious onset (HP:0003587)2.36885904
41Termporal pattern (HP:0011008)2.36885904
42Pustule (HP:0200039)2.36004667
43Abnormality of iron homeostasis (HP:0011031)2.35405418
44Xanthomatosis (HP:0000991)2.34571441
45Petechiae (HP:0000967)2.34096156
46Hypertensive crisis (HP:0100735)2.31929316
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31570537
48Asymmetry of the thorax (HP:0001555)2.27711060
49Multiple enchondromatosis (HP:0005701)2.22691002
50Hyperammonemia (HP:0001987)2.20207726
51Bowel incontinence (HP:0002607)2.18348134
52Nausea (HP:0002018)2.17378494
53Abnormality of transition element cation homeostasis (HP:0011030)2.17205479
54Hypobetalipoproteinemia (HP:0003563)2.16355542
55Autoimmune thrombocytopenia (HP:0001973)2.15129312
56Generalized hyperpigmentation (HP:0007440)2.13973670
57Overlapping toe (HP:0001845)2.13719865
58Abnormality of oral frenula (HP:0000190)2.13495591
59Abnormal large intestine physiology (HP:0012700)2.12954130
60Urticaria (HP:0001025)2.12883691
61Hyperglycinemia (HP:0002154)2.09723844
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.08827989
63Delusions (HP:0000746)2.07374752
64Intrahepatic cholestasis (HP:0001406)2.06812075
65Hyponatremia (HP:0002902)2.05127602
66Macroorchidism (HP:0000053)2.04454884
67Verrucae (HP:0200043)2.01965342
68Papilloma (HP:0012740)2.01965342
69Back pain (HP:0003418)2.01499116
70Patellar dislocation (HP:0002999)2.00041852
71Chromsome breakage (HP:0040012)1.99998850
72Gout (HP:0001997)1.97537448
73Abnormality of the Achilles tendon (HP:0005109)1.97274197
74Metaphyseal cupping (HP:0003021)1.94251359
75Vertebral compression fractures (HP:0002953)1.93137613
76Increased nuchal translucency (HP:0010880)1.92106839
77Abnormality of sodium homeostasis (HP:0010931)1.92045312
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90422223
79Hemorrhage of the eye (HP:0011885)1.90120783
80Progressive external ophthalmoplegia (HP:0000590)1.88354333
81Status epilepticus (HP:0002133)1.86529586
82Abnormality of pyrimidine metabolism (HP:0004353)1.86329554
83Sparse lateral eyebrow (HP:0005338)1.86141849
84Impaired platelet aggregation (HP:0003540)1.85273025
85Abnormal platelet function (HP:0011869)1.85273025
86Metabolic acidosis (HP:0001942)1.84754565
87Heterotopia (HP:0002282)1.83925825
88Abnormality of glycine metabolism (HP:0010895)1.83308987
89Abnormality of serine family amino acid metabolism (HP:0010894)1.83308987
90Pallor (HP:0000980)1.83187285
91Abnormality of the tricuspid valve (HP:0001702)1.83050427
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81215879
93Deep philtrum (HP:0002002)1.80151509
94Septate vagina (HP:0001153)1.79757454
95Prolonged bleeding time (HP:0003010)1.79434591
96Testicular neoplasm (HP:0010788)1.78287985
97Abnormality of the anterior horn cell (HP:0006802)1.77400796
98Degeneration of anterior horn cells (HP:0002398)1.77400796
99Ketosis (HP:0001946)1.77339394
100Atelectasis (HP:0100750)1.77270295
101Achilles tendon contracture (HP:0001771)1.77220078
102Osteomalacia (HP:0002749)1.77106837
103Dysmetric saccades (HP:0000641)1.75978615
104Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74864400
105Papillary thyroid carcinoma (HP:0002895)1.74165895
106Lower limb hyperreflexia (HP:0002395)1.74062889
107Hyperglycinuria (HP:0003108)1.73339677
108Deep palmar crease (HP:0006191)1.72916596
109Basal cell carcinoma (HP:0002671)1.72070462
110Hyperparathyroidism (HP:0000843)1.71820369
111Fatigue (HP:0012378)1.71263363
112Epistaxis (HP:0000421)1.70857774
113Broad palm (HP:0001169)1.70527370
114Cortical dysplasia (HP:0002539)1.69871421
115Increased mean platelet volume (HP:0011877)1.69868768
116Abnormal platelet volume (HP:0011876)1.68831995
117Hyperlipoproteinemia (HP:0010980)1.67958361
118Macrocytic anemia (HP:0001972)1.67390655
119Progressive muscle weakness (HP:0003323)1.67123889
120Abnormal foot bone ossification (HP:0010675)1.66875183
121Ragged-red muscle fibers (HP:0003200)1.66503827
122Abnormality of the gastric mucosa (HP:0004295)1.66309839
123Thrombocytosis (HP:0001894)1.66261197
124Disproportionate tall stature (HP:0001519)1.66046804
125Birth length less than 3rd percentile (HP:0003561)1.65989640
126Pseudobulbar signs (HP:0002200)1.65829981
127Albinism (HP:0001022)1.65253104
128Hypolipoproteinemia (HP:0010981)1.63288099
129Progressive microcephaly (HP:0000253)1.63129163
130Pathologic fracture (HP:0002756)1.62596340
131Slow saccadic eye movements (HP:0000514)1.61755986
132Abnormality of the fingertips (HP:0001211)1.61625345
133Distal lower limb amyotrophy (HP:0008944)1.61210688
134Upper limb muscle weakness (HP:0003484)1.61053161
135Brushfield spots (HP:0001088)1.60668531
136Cerebral hypomyelination (HP:0006808)1.59891107
137Cellulitis (HP:0100658)1.58742679
138Chronic otitis media (HP:0000389)1.58714416
139Nonimmune hydrops fetalis (HP:0001790)1.58264976
140Recurrent viral infections (HP:0004429)1.58072727
141Abnormality of nucleobase metabolism (HP:0010932)1.57991063
142Gastrointestinal dysmotility (HP:0002579)1.57987687
143Abnormality of the acetabulum (HP:0003170)1.57503360
144Autoamputation (HP:0001218)1.57295389
145IgM deficiency (HP:0002850)1.57143310
146Decreased motor nerve conduction velocity (HP:0003431)1.56278521
147Uterine leiomyosarcoma (HP:0002891)1.56264522
148Leiomyosarcoma (HP:0100243)1.56264522
149Upper limb amyotrophy (HP:0009129)1.55959129
150Distal upper limb amyotrophy (HP:0007149)1.55959129
151Severe muscular hypotonia (HP:0006829)1.55388050
152Abnormality of complement system (HP:0005339)1.54831179
153Delayed CNS myelination (HP:0002188)1.53956721
154Abnormal number of erythroid precursors (HP:0012131)1.52885380
155Abnormality of the thoracic spine (HP:0100711)1.52570505
156Prominent nose (HP:0000448)1.51894874
157Glomerulonephritis (HP:0000099)1.51697971
158Slender build (HP:0001533)1.50774796
159Personality changes (HP:0000751)1.50503447
160Germ cell neoplasia (HP:0100728)1.49954241
161Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.48716155
162Abnormal tarsal ossification (HP:0008369)1.48564852
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.48501257
164Bruising susceptibility (HP:0000978)1.47972524
165Abnormality of cells of the erythroid lineage (HP:0012130)1.43894400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.97035872
2SMG12.87463208
3ICK2.78740042
4SCYL22.77970824
5PRPF4B2.61195947
6TRIB32.58732718
7EEF2K2.48576464
8TESK22.41605773
9NEK12.38373647
10STK102.37818581
11CDC72.37794475
12BUB12.35408585
13MAP4K12.27329179
14SIK12.17301653
15MAP3K102.02604133
16DYRK32.01863195
17NEK21.98571931
18MAP3K111.97584018
19IRAK31.93975492
20TAOK31.90176647
21ERN11.89536225
22GRK61.87772210
23MAP3K81.85981160
24BCKDK1.84473139
25PKN21.78336860
26* EIF2AK11.73697487
27STK41.71873792
28BRSK11.69283156
29RPS6KA41.50521887
30CDK121.45287919
31TAOK11.43332941
32MST1R1.42949584
33EPHA21.42828531
34MAPK111.37385331
35CDK191.28615958
36WEE11.28324788
37KSR21.26922365
38SYK1.22203549
39MTOR1.22113705
40TTK1.22089581
41WNK11.16877336
42MAP2K31.14747209
43MAP3K21.13964421
44ALK1.13181050
45LRRK21.11967715
46PBK1.10278856
47PIM11.09865051
48JAK21.08773338
49FLT31.07002931
50PLK11.06185627
51DYRK1B1.04513491
52NEK91.03976361
53CDK41.03555802
54FES1.00301047
55TBK10.99517568
56AURKB0.97222356
57MAP3K10.96383188
58RIPK40.92808892
59CAMK1D0.92043476
60RET0.89929835
61BRSK20.89090972
62PAK40.86920930
63SIK30.86392013
64CDK60.86270114
65KSR10.86147383
66DAPK20.85213146
67CAMK1G0.83627858
68ZAP700.82904746
69SRPK10.82436819
70CHEK20.81681645
71NME20.78505244
72MAPKAPK30.78344847
73ILK0.78280374
74MAP3K30.77950358
75LMTK20.77557134
76DMPK0.77281722
77FGFR30.73445611
78PTK60.73225136
79AURKA0.72821757
80CDK80.71403367
81PDGFRA0.70617799
82PIM20.69482585
83MAP2K40.69234409
84HIPK20.67713237
85ATR0.67096958
86BLK0.66654747
87PDPK10.66331162
88MAP3K90.65613376
89CDK90.64747268
90DAPK30.64390736
91ERBB20.64309856
92CDK70.63764683
93CHEK10.62769172
94MET0.62654666
95MAP2K10.62376536
96LYN0.62039082
97MAP2K60.61778006
98TYK20.61733110
99BRD40.61469193
100YES10.59261767
101ARAF0.57884491
102MST40.57876641
103FGFR40.57760004
104RAF10.56182459
105PTK20.55809586
106MARK20.55524532
107RIPK10.54589257
108SGK30.54565609
109STK160.53962114
110MAP2K20.52530316
111CDK20.49649512
112BRAF0.49136326
113TESK10.48991536
114RPS6KB20.48971074
115AKT20.48636904
116TRPM70.47302724
117TAOK20.46583879
118ATM0.45543368
119CAMKK10.44367525
120LATS20.43877709
121ABL20.43806947
122BTK0.43471068
123MAPKAPK20.43071954
124PRKAA10.42512233
125TEC0.41894769
126FGR0.41519615
127BMPR20.41017019
128NTRK10.38701132
129MARK30.38692268
130CDK11A0.38493097
131CCNB10.37783072
132CDK140.36746269
133EPHB10.36636048
134SIK20.36477594
135BMX0.35158720
136MELK0.34758935
137CDK150.34283304
138MINK10.32870626
139CSF1R0.32284835
140PDK10.31797651
141CDK180.30675196
142CDK10.29567584
143STK30.28633957
144RPS6KA50.27872147
145MAP3K70.27861077
146CLK10.27723825

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.59149613
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.52577225
3DNA replication_Homo sapiens_hsa030303.37062035
4Vitamin B6 metabolism_Homo sapiens_hsa007503.34953929
5Nitrogen metabolism_Homo sapiens_hsa009103.26073786
6Sulfur relay system_Homo sapiens_hsa041222.60625329
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51701416
8One carbon pool by folate_Homo sapiens_hsa006702.30393853
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14333793
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14016191
11Cell cycle_Homo sapiens_hsa041102.11760310
12Mismatch repair_Homo sapiens_hsa034301.99241792
13Selenocompound metabolism_Homo sapiens_hsa004501.95039030
14Systemic lupus erythematosus_Homo sapiens_hsa053221.87242078
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.84988391
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84731624
17Arginine biosynthesis_Homo sapiens_hsa002201.81707646
18Endometrial cancer_Homo sapiens_hsa052131.76038085
19Folate biosynthesis_Homo sapiens_hsa007901.73904366
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72960836
21Base excision repair_Homo sapiens_hsa034101.72497266
22Biosynthesis of amino acids_Homo sapiens_hsa012301.72155319
23Renal cell carcinoma_Homo sapiens_hsa052111.61443666
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51339983
25Fructose and mannose metabolism_Homo sapiens_hsa000511.48912363
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.43677342
27Pentose phosphate pathway_Homo sapiens_hsa000301.43375107
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.43091246
29Carbon metabolism_Homo sapiens_hsa012001.35933020
30Fatty acid degradation_Homo sapiens_hsa000711.32517859
31RNA transport_Homo sapiens_hsa030131.30933189
32Pyruvate metabolism_Homo sapiens_hsa006201.29340369
33p53 signaling pathway_Homo sapiens_hsa041151.26739741
34Spliceosome_Homo sapiens_hsa030401.25150620
35Prostate cancer_Homo sapiens_hsa052151.21795462
36Small cell lung cancer_Homo sapiens_hsa052221.21080874
37Homologous recombination_Homo sapiens_hsa034401.18593855
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17575028
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16589486
40Non-small cell lung cancer_Homo sapiens_hsa052231.16343799
41Tryptophan metabolism_Homo sapiens_hsa003801.16039441
42Bladder cancer_Homo sapiens_hsa052191.15067225
43mTOR signaling pathway_Homo sapiens_hsa041501.13463808
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07964088
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07506658
46Platelet activation_Homo sapiens_hsa046111.06638134
47Other glycan degradation_Homo sapiens_hsa005111.06366477
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.05634157
49Chronic myeloid leukemia_Homo sapiens_hsa052201.04884993
50N-Glycan biosynthesis_Homo sapiens_hsa005101.04810081
51Notch signaling pathway_Homo sapiens_hsa043301.04578170
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04355056
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01931997
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00042850
55Choline metabolism in cancer_Homo sapiens_hsa052310.99152155
56ErbB signaling pathway_Homo sapiens_hsa040120.98583271
57Nucleotide excision repair_Homo sapiens_hsa034200.97208970
58Lysine degradation_Homo sapiens_hsa003100.95020692
59ABC transporters_Homo sapiens_hsa020100.94160844
60B cell receptor signaling pathway_Homo sapiens_hsa046620.93053454
61Caffeine metabolism_Homo sapiens_hsa002320.92875100
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92611147
63Adherens junction_Homo sapiens_hsa045200.90247223
64MicroRNAs in cancer_Homo sapiens_hsa052060.87899292
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.85948258
66Fat digestion and absorption_Homo sapiens_hsa049750.84780717
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84449262
68Colorectal cancer_Homo sapiens_hsa052100.84046975
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83150756
70Pyrimidine metabolism_Homo sapiens_hsa002400.82893041
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82309746
72Galactose metabolism_Homo sapiens_hsa000520.82208982
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82180319
74beta-Alanine metabolism_Homo sapiens_hsa004100.81179492
75Complement and coagulation cascades_Homo sapiens_hsa046100.80488669
76Pancreatic cancer_Homo sapiens_hsa052120.80453918
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80410377
78Inositol phosphate metabolism_Homo sapiens_hsa005620.79398692
79HIF-1 signaling pathway_Homo sapiens_hsa040660.79002154
80Viral carcinogenesis_Homo sapiens_hsa052030.77322756
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76108082
82Prion diseases_Homo sapiens_hsa050200.75981219
83Peroxisome_Homo sapiens_hsa041460.75700221
84Fatty acid biosynthesis_Homo sapiens_hsa000610.74985910
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74656418
86Ribosome_Homo sapiens_hsa030100.73933370
87Bile secretion_Homo sapiens_hsa049760.73514076
88Oocyte meiosis_Homo sapiens_hsa041140.73482466
89Apoptosis_Homo sapiens_hsa042100.72998186
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72669409
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70053558
92Propanoate metabolism_Homo sapiens_hsa006400.70051060
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.69541607
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68730454
95PPAR signaling pathway_Homo sapiens_hsa033200.68601276
96Staphylococcus aureus infection_Homo sapiens_hsa051500.66178748
97Hepatitis B_Homo sapiens_hsa051610.63846055
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62265536
99Endocytosis_Homo sapiens_hsa041440.61727683
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59888878
101Prolactin signaling pathway_Homo sapiens_hsa049170.59878333
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58761135
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58022637
104Antigen processing and presentation_Homo sapiens_hsa046120.57560856
105Thyroid cancer_Homo sapiens_hsa052160.57277298
106Glioma_Homo sapiens_hsa052140.55353283
107Alcoholism_Homo sapiens_hsa050340.55127094
108Phenylalanine metabolism_Homo sapiens_hsa003600.54986605
109* Hepatitis C_Homo sapiens_hsa051600.54791127
110Butanoate metabolism_Homo sapiens_hsa006500.54278285
111Insulin resistance_Homo sapiens_hsa049310.53646394
112Proteoglycans in cancer_Homo sapiens_hsa052050.52783391
113Leishmaniasis_Homo sapiens_hsa051400.52486296
114Acute myeloid leukemia_Homo sapiens_hsa052210.51567924
115* Herpes simplex infection_Homo sapiens_hsa051680.51452152
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.50933098
117AMPK signaling pathway_Homo sapiens_hsa041520.48608270
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48538101
119Melanoma_Homo sapiens_hsa052180.47279183
120Fanconi anemia pathway_Homo sapiens_hsa034600.46820732
121Primary immunodeficiency_Homo sapiens_hsa053400.46499881
122Arginine and proline metabolism_Homo sapiens_hsa003300.44062574
123Glutathione metabolism_Homo sapiens_hsa004800.43792288
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43534027
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41743902
126Focal adhesion_Homo sapiens_hsa045100.41523764
127Steroid biosynthesis_Homo sapiens_hsa001000.41174831
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40818704
129Shigellosis_Homo sapiens_hsa051310.40609580
130* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39686374
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.39576711
132Non-homologous end-joining_Homo sapiens_hsa034500.38893148
133Proteasome_Homo sapiens_hsa030500.36984945
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36935428
135mRNA surveillance pathway_Homo sapiens_hsa030150.36370230
136* Epstein-Barr virus infection_Homo sapiens_hsa051690.35230747
137Hematopoietic cell lineage_Homo sapiens_hsa046400.34989674
138FoxO signaling pathway_Homo sapiens_hsa040680.34744911
139Fatty acid metabolism_Homo sapiens_hsa012120.33323766
140Starch and sucrose metabolism_Homo sapiens_hsa005000.31100832
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30892381
142Glycerolipid metabolism_Homo sapiens_hsa005610.30353342
143VEGF signaling pathway_Homo sapiens_hsa043700.30282254
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.29167920
145HTLV-I infection_Homo sapiens_hsa051660.29124121
146Insulin signaling pathway_Homo sapiens_hsa049100.27208062

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