EIF2AK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.56435266
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26133105
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.26133105
4modulation by symbiont of host immune response (GO:0052553)5.26133105
5positive regulation by symbiont of host defense response (GO:0052509)5.26133105
6modulation by symbiont of host defense response (GO:0052031)5.26133105
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26133105
8positive regulation of interferon-alpha production (GO:0032727)5.19203625
9regulation of interferon-alpha production (GO:0032647)4.89185153
10response to type I interferon (GO:0034340)4.81553135
11type I interferon signaling pathway (GO:0060337)4.76131783
12cellular response to type I interferon (GO:0071357)4.76131783
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23687923
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23687923
15antigen processing and presentation of endogenous antigen (GO:0019883)4.07851659
16regulation of interferon-beta biosynthetic process (GO:0045357)4.07131642
17* response to interferon-alpha (GO:0035455)4.04069187
18neutrophil activation involved in immune response (GO:0002283)3.97120572
19* regulation of viral genome replication (GO:0045069)3.94305308
20positive regulation of natural killer cell differentiation (GO:0032825)3.90901793
21regulation of MHC class I biosynthetic process (GO:0045343)3.89817231
22positive regulation of interferon-beta production (GO:0032728)3.89314461
23response to peptidoglycan (GO:0032494)3.89231221
24cellular response to interferon-beta (GO:0035458)3.81708172
25cellular response to exogenous dsRNA (GO:0071360)3.76699774
26* negative regulation of viral genome replication (GO:0045071)3.73587221
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.72009071
28cellular response to ethanol (GO:0071361)3.66317112
29* negative regulation of viral process (GO:0048525)3.65859903
30cellular response to interferon-alpha (GO:0035457)3.62363159
31superoxide anion generation (GO:0042554)3.60888041
32response to interferon-beta (GO:0035456)3.51982853
33macrophage activation involved in immune response (GO:0002281)3.49329282
34positive regulation of antigen processing and presentation (GO:0002579)3.47571656
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43188574
36nuclear pore complex assembly (GO:0051292)3.39774692
37interferon-gamma-mediated signaling pathway (GO:0060333)3.37916207
38regulation of RIG-I signaling pathway (GO:0039535)3.36376317
39response to exogenous dsRNA (GO:0043330)3.35599437
40detection of other organism (GO:0098543)3.33771495
41positive regulation of gamma-delta T cell activation (GO:0046645)3.32894921
42positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.31988428
43mitotic sister chromatid cohesion (GO:0007064)3.31428906
44detection of molecule of bacterial origin (GO:0032490)3.31030887
45immunoglobulin mediated immune response (GO:0016064)3.29713311
46positive regulation of cellular amide metabolic process (GO:0034250)3.28941510
47I-kappaB phosphorylation (GO:0007252)3.28759288
48neutrophil activation (GO:0042119)3.28012558
49cytoplasmic mRNA processing body assembly (GO:0033962)3.27158010
50* response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25160242
51* response to host immune response (GO:0052572)3.25160242
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.24888929
53natural killer cell mediated cytotoxicity (GO:0042267)3.19080291
54natural killer cell mediated immunity (GO:0002228)3.19080291
55regulation of T-helper 1 cell differentiation (GO:0045625)3.17938483
56T-helper 1 type immune response (GO:0042088)3.17924490
57granulocyte activation (GO:0036230)3.17176250
58microglial cell activation (GO:0001774)3.16192317
59cellular response to virus (GO:0098586)3.14985720
60negative regulation of interleukin-12 production (GO:0032695)3.13627781
61regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.12858229
62regulation of antigen processing and presentation (GO:0002577)3.08975412
63positive regulation of interleukin-12 production (GO:0032735)3.08138558
64negative regulation of T cell mediated immunity (GO:0002710)3.07982193
65positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.04654360
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.04654360
67regulation of protein polyubiquitination (GO:1902914)3.00567984
68positive regulation of defense response to virus by host (GO:0002230)3.00342201
69monoubiquitinated protein deubiquitination (GO:0035520)3.00326024
70response to dsRNA (GO:0043331)2.96280321
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94870981
72negative regulation of B cell proliferation (GO:0030889)2.94849158
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92556468
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90233432
75* defense response to virus (GO:0051607)2.90187629
76positive regulation of interleukin-1 beta secretion (GO:0050718)2.89350931
77regulation of interleukin-12 biosynthetic process (GO:0045075)2.87674174
78* response to host defenses (GO:0052200)2.85353335
79* response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85353335
80* response to host (GO:0075136)2.85353335
81detection of bacterium (GO:0016045)2.85294991
82regulation of interleukin-1 beta secretion (GO:0050706)2.84777167
83detection of external biotic stimulus (GO:0098581)2.84678747
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84319080
85positive regulation of chemokine biosynthetic process (GO:0045080)2.84232119
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83042400
87nuclear pore organization (GO:0006999)2.82641605
88positive regulation of response to biotic stimulus (GO:0002833)2.82604357
89regulation of interferon-beta production (GO:0032648)2.82418409
90T cell migration (GO:0072678)2.82388368
91phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81306069
92regulation of natural killer cell differentiation (GO:0032823)2.80754566
93response to muramyl dipeptide (GO:0032495)2.78975720
94regulation of response to interferon-gamma (GO:0060330)2.78940798
95regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.77948745
96positive regulation of type 2 immune response (GO:0002830)2.74984636
97response to interleukin-15 (GO:0070672)2.74520627
98myeloid cell activation involved in immune response (GO:0002275)2.73871294
99JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73491004
100interleukin-6-mediated signaling pathway (GO:0070102)2.71766020
101regulation of activation of Janus kinase activity (GO:0010533)2.71001432
102negative regulation of cell killing (GO:0031342)2.70975349
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70975349
104response to interferon-gamma (GO:0034341)2.70131599
105cellular response to interferon-gamma (GO:0071346)2.68422132
106protein K11-linked deubiquitination (GO:0035871)2.67922236
107necroptotic process (GO:0070266)2.67819735
108dendritic cell chemotaxis (GO:0002407)2.67093933
109positive regulation of interleukin-1 secretion (GO:0050716)2.66804569
110regulation of B cell receptor signaling pathway (GO:0050855)2.66708032
111myeloid dendritic cell activation (GO:0001773)2.65760289
112B cell proliferation (GO:0042100)2.65541728
113hepatocyte apoptotic process (GO:0097284)2.65456870
114regulation of interferon-gamma biosynthetic process (GO:0045072)2.65453112
115positive regulation of heat generation (GO:0031652)2.64110713
116cytokine secretion (GO:0050663)2.63474701
117macrophage activation (GO:0042116)2.63398670
118positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63191812
119regulation of defense response to virus by host (GO:0050691)2.62638812
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61076985
121negative regulation of type I interferon production (GO:0032480)2.60606630
122positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59729850
123interferon-gamma production (GO:0032609)2.59381704
124pore complex assembly (GO:0046931)2.59306645
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58935176
126respiratory burst (GO:0045730)2.58922262
127positive regulation of protein import into nucleus, translocation (GO:0033160)2.58558811
128production of molecular mediator involved in inflammatory response (GO:0002532)2.58281883
129pre-miRNA processing (GO:0031054)2.58145905
130positive regulation of T cell migration (GO:2000406)2.58052133
131dendritic cell migration (GO:0036336)2.58003918
132detection of biotic stimulus (GO:0009595)2.57721490
133B cell receptor signaling pathway (GO:0050853)2.57128513
134regulation of gamma-delta T cell activation (GO:0046643)2.56530590
135regulation of necroptotic process (GO:0060544)2.56214916
136myeloid dendritic cell differentiation (GO:0043011)2.54168241
137cellular extravasation (GO:0045123)2.53908669
138defense response to protozoan (GO:0042832)2.53218610
139germinal center formation (GO:0002467)2.52922553
140regulation of interleukin-1 secretion (GO:0050704)2.52352950
141* response to virus (GO:0009615)2.52164970
142cellular response to interleukin-15 (GO:0071350)2.51554157
143regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50689263
144B cell mediated immunity (GO:0019724)2.50328782
145JAK-STAT cascade (GO:0007259)2.49041455
146natural killer cell activation involved in immune response (GO:0002323)2.48771841
147negative regulation of viral entry into host cell (GO:0046597)2.48280349
148negative regulation of DNA repair (GO:0045738)2.48165002
149regulation of establishment of cell polarity (GO:2000114)2.46914957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.78575168
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.53496908
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.28308096
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.91589585
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.26147248
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.16254338
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.47901516
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03812076
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03123770
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.87628398
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75622090
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66507419
13GATA1_22025678_ChIP-Seq_K562_Human2.34232537
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30627854
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25851258
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24093910
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.09935188
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.09858057
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08907996
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02631449
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95828516
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90856755
23TP53_16413492_ChIP-PET_HCT116_Human1.68947234
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67389116
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65135510
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64220953
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64071537
28SCL_19346495_ChIP-Seq_HPC-7_Human1.60168093
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.58193000
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54791865
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.53694165
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.52842686
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52255821
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51558093
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51098202
36PU_27001747_Chip-Seq_BMDM_Mouse1.50109365
37VDR_24787735_ChIP-Seq_THP-1_Human1.47869727
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47721900
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46937434
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46755688
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44398092
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.43221101
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.39205886
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37437811
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36640714
46RUNX_20019798_ChIP-Seq_JUKART_Human1.36568047
47SPI1_23547873_ChIP-Seq_NB4_Human1.36493764
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36121926
49MYB_26560356_Chip-Seq_TH2_Human1.35387467
50E2F7_22180533_ChIP-Seq_HELA_Human1.30176777
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28233151
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26034014
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25239123
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22965677
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21532754
56MYB_26560356_Chip-Seq_TH1_Human1.21361897
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21000544
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20824158
59STAT3_23295773_ChIP-Seq_U87_Human1.20756764
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20323253
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19707357
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.19209582
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17618260
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.15689787
65CJUN_26792858_Chip-Seq_BT549_Human1.15484313
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.15466637
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13404836
68* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13372085
69FUS_26573619_Chip-Seq_HEK293_Human1.12720219
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11939943
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11906701
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11422708
73P53_22387025_ChIP-Seq_ESCs_Mouse1.11089971
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10733006
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.10604311
76PU1_27457419_Chip-Seq_LIVER_Mouse1.10557410
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10432581
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.09976755
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08523136
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08523136
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07510669
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07305488
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.07189541
84OCT4_18555785_Chip-Seq_ESCs_Mouse1.07078222
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.07018335
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06275569
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06275569
88* EWS_26573619_Chip-Seq_HEK293_Human1.05720877
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.05623500
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.05219359
91TAF15_26573619_Chip-Seq_HEK293_Human1.04485517
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02582164
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01953626
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01788502
95TP53_18474530_ChIP-ChIP_U2OS_Human1.01473867
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01415352
97P300_19829295_ChIP-Seq_ESCs_Human1.00717874
98SPI1_23127762_ChIP-Seq_K562_Human1.00111911
99GATA3_27048872_Chip-Seq_THYMUS_Human1.00002933
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99929118
101P300_18555785_Chip-Seq_ESCs_Mouse0.99805839
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99568008
103ER_23166858_ChIP-Seq_MCF-7_Human0.98303580
104TP63_23658742_ChIP-Seq_EP156T_Human0.97766878
105AHR_22903824_ChIP-Seq_MCF-7_Human0.97519147
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97445357
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.96329451
108ZFX_18555785_Chip-Seq_ESCs_Mouse0.96221097
109CDX2_22108803_ChIP-Seq_LS180_Human0.96145015
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95644567
111SOX2_20726797_ChIP-Seq_SW620_Human0.95611958
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95536715
113ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95499334
114SMAD4_21799915_ChIP-Seq_A2780_Human0.95189954
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.94398250
116RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94102553
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.94098119
118SOX2_18555785_Chip-Seq_ESCs_Mouse0.93722801
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92416433
120GATA3_26560356_Chip-Seq_TH2_Human0.92235446
121CTCF_18555785_Chip-Seq_ESCs_Mouse0.91293178
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.90490156
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90403952
124* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89576397
125BRD4_25478319_ChIP-Seq_HGPS_Human0.89403658
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88237045
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.88114227
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87880235
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86169896
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.85698605
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85590445
132KLF4_18555785_Chip-Seq_ESCs_Mouse0.85284689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41792374
2MP0008057_abnormal_DNA_replication4.00402816
3MP0009785_altered_susceptibility_to3.54341310
4MP0003724_increased_susceptibility_to3.13413239
5MP0003436_decreased_susceptibility_to2.80376588
6MP0005387_immune_system_phenotype2.75368532
7MP0001790_abnormal_immune_system2.75368532
8* MP0002148_abnormal_hypersensitivity_rea2.72963646
9MP0008438_abnormal_cutaneous_collagen2.58544966
10MP0005000_abnormal_immune_tolerance2.53696287
11MP0000569_abnormal_digit_pigmentation2.52753919
12MP0002419_abnormal_innate_immunity2.52744873
13* MP0005025_abnormal_response_to2.51621323
14MP0000685_abnormal_immune_system2.44641460
15MP0005671_abnormal_response_to2.40499272
16MP0002452_abnormal_antigen_presenting2.33610148
17MP0001800_abnormal_humoral_immune2.31699255
18MP0002009_preneoplasia2.25453254
19MP0006054_spinal_hemorrhage2.15720269
20* MP0002723_abnormal_immune_serum2.14842223
21MP0006082_CNS_inflammation2.10070730
22MP0002166_altered_tumor_susceptibility2.05659504
23MP0002006_tumorigenesis2.00644450
24MP0009764_decreased_sensitivity_to1.94547623
25* MP0001819_abnormal_immune_cell1.91023139
26* MP0002420_abnormal_adaptive_immunity1.86678443
27MP0002877_abnormal_melanocyte_morpholog1.78510373
28MP0010155_abnormal_intestine_physiology1.73589447
29MP0001533_abnormal_skeleton_physiology1.72175188
30MP0005464_abnormal_platelet_physiology1.69009962
31MP0003300_gastrointestinal_ulcer1.65442265
32MP0004510_myositis1.63218281
33MP0005076_abnormal_cell_differentiation1.58456355
34MP0004808_abnormal_hematopoietic_stem1.56688361
35MP0001845_abnormal_inflammatory_respons1.54306592
36MP0004947_skin_inflammation1.53880147
37MP0002405_respiratory_system_inflammati1.47324714
38MP0002277_abnormal_respiratory_mucosa1.46650767
39MP0003448_altered_tumor_morphology1.46063356
40MP0001853_heart_inflammation1.45409735
41MP0003303_peritoneal_inflammation1.43224180
42* MP0000716_abnormal_immune_system1.40035053
43MP0002998_abnormal_bone_remodeling1.39734520
44* MP0002398_abnormal_bone_marrow1.37166693
45MP0008469_abnormal_protein_level1.35994265
46MP0010678_abnormal_skin_adnexa1.35719298
47MP0010307_abnormal_tumor_latency1.35242664
48MP0009278_abnormal_bone_marrow1.34721871
49MP0005503_abnormal_tendon_morphology1.34512333
50MP0005174_abnormal_tail_pigmentation1.33075757
51MP0004782_abnormal_surfactant_physiolog1.32846144
52MP0005397_hematopoietic_system_phenotyp1.29519616
53MP0001545_abnormal_hematopoietic_system1.29519616
54MP0002396_abnormal_hematopoietic_system1.29025060
55MP0005275_abnormal_skin_tensile1.28188016
56MP0000015_abnormal_ear_pigmentation1.26490457
57MP0005058_abnormal_lysosome_morphology1.26312917
58MP0003656_abnormal_erythrocyte_physiolo1.24924958
59MP0000858_altered_metastatic_potential1.23523552
60MP0005257_abnormal_intraocular_pressure1.21686173
61MP0010094_abnormal_chromosome_stability1.21645502
62MP0003566_abnormal_cell_adhesion1.21376846
63MP0003045_fibrosis1.20989544
64MP0003221_abnormal_cardiomyocyte_apopto1.20431119
65MP0000343_altered_response_to1.18709518
66MP0004883_abnormal_blood_vessel1.17041194
67MP0003091_abnormal_cell_migration1.15650672
68MP0003941_abnormal_skin_development1.13859841
69MP0002138_abnormal_hepatobiliary_system1.13201053
70MP0005390_skeleton_phenotype1.11984962
71MP0003943_abnormal_hepatobiliary_system1.11930302
72* MP0002429_abnormal_blood_cell1.11714524
73MP0005621_abnormal_cell_physiology1.10465778
74MP0001873_stomach_inflammation1.07169894
75MP0005171_absent_coat_pigmentation1.06739247
76MP0005310_abnormal_salivary_gland1.06672122
77MP0003763_abnormal_thymus_physiology1.06585636
78MP0003828_pulmonary_edema1.06164733
79MP0000689_abnormal_spleen_morphology1.05025652
80MP0003172_abnormal_lysosome_physiology1.04050616
81MP0000703_abnormal_thymus_morphology1.03830214
82MP0000490_abnormal_crypts_of1.03631228
83MP0002933_joint_inflammation1.03607020
84MP0002332_abnormal_exercise_endurance1.03113426
85MP0003191_abnormal_cellular_cholesterol1.02998807
86MP0000427_abnormal_hair_cycle1.01470907
87MP0003705_abnormal_hypodermis_morpholog1.00830634
88MP0000371_diluted_coat_color1.00372939
89MP0002722_abnormal_immune_system0.99823323
90MP0001958_emphysema0.99249062
91MP0000767_abnormal_smooth_muscle0.98000521
92MP0003890_abnormal_embryonic-extraembry0.97122555
93MP0009697_abnormal_copulation0.94924456
94MP0003252_abnormal_bile_duct0.94276156
95MP0001879_abnormal_lymphatic_vessel0.94044280
96MP0009333_abnormal_splenocyte_physiolog0.93973961
97MP0000383_abnormal_hair_follicle0.93939548
98MP0008877_abnormal_DNA_methylation0.93805388
99* MP0009763_increased_sensitivity_to0.93445167
100MP0003279_aneurysm0.93354895
101MP0002060_abnormal_skin_morphology0.92024712
102MP0001915_intracranial_hemorrhage0.87293526
103MP0002254_reproductive_system_inflammat0.86808630
104MP0003787_abnormal_imprinting0.86500638
105MP0005023_abnormal_wound_healing0.84320961
106MP0008007_abnormal_cellular_replicative0.81264438
107MP0003183_abnormal_peptide_metabolism0.78784911
108MP0003950_abnormal_plasma_membrane0.78584127
109MP0005623_abnormal_meninges_morphology0.77909533
110MP0002019_abnormal_tumor_incidence0.77872167
111MP0001348_abnormal_lacrimal_gland0.77119861
112MP0001188_hyperpigmentation0.75434901
113MP0009115_abnormal_fat_cell0.75242753
114MP0005384_cellular_phenotype0.74607020
115MP0001346_abnormal_lacrimal_gland0.74509336
116MP0002928_abnormal_bile_duct0.73461486
117MP0003453_abnormal_keratinocyte_physiol0.73043728
118MP0010352_gastrointestinal_tract_polyps0.71109749
119MP0001881_abnormal_mammary_gland0.70756181
120MP0005164_abnormal_response_to0.69807766
121MP0003795_abnormal_bone_structure0.69550401
122MP0010234_abnormal_vibrissa_follicle0.69535618
123MP0003868_abnormal_feces_composition0.69107413
124MP0000350_abnormal_cell_proliferation0.68379242
125MP0001851_eye_inflammation0.67934137
126MP0000627_abnormal_mammary_gland0.67848183
127MP0002132_abnormal_respiratory_system0.67732306
128MP0000372_irregular_coat_pigmentation0.66916046
129MP0000249_abnormal_blood_vessel0.66836694
130MP0002168_other_aberrant_phenotype0.66482249
131MP0000516_abnormal_urinary_system0.66341236
132MP0005367_renal/urinary_system_phenotyp0.66341236
133MP0003866_abnormal_defecation0.63119585

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.72686025
2Recurrent abscess formation (HP:0002722)4.67049285
3Recurrent bacterial skin infections (HP:0005406)4.38305734
4Prostate neoplasm (HP:0100787)4.36199602
5Myositis (HP:0100614)3.83669765
6Retrobulbar optic neuritis (HP:0100654)3.79183306
7Optic neuritis (HP:0100653)3.79183306
8Orchitis (HP:0100796)3.76997868
9Autoimmune thrombocytopenia (HP:0001973)3.58467229
10T lymphocytopenia (HP:0005403)3.52788294
11Recurrent gram-negative bacterial infections (HP:0005420)3.52113551
12Elevated erythrocyte sedimentation rate (HP:0003565)3.33047415
13Recurrent fungal infections (HP:0002841)3.26838647
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24001126
15Mediastinal lymphadenopathy (HP:0100721)3.21864417
16Chronic otitis media (HP:0000389)3.20051895
17Vasculitis (HP:0002633)3.16200364
18Chromsome breakage (HP:0040012)3.09242121
19Gingivitis (HP:0000230)3.05473474
20Abnormality of macrophages (HP:0004311)3.04295817
21Recurrent viral infections (HP:0004429)3.01541894
22Periodontitis (HP:0000704)2.96821809
23Recurrent skin infections (HP:0001581)2.95209938
24Papillary thyroid carcinoma (HP:0002895)2.92737361
25Basal ganglia calcification (HP:0002135)2.90921959
26Chronic mucocutaneous candidiasis (HP:0002728)2.82681584
27Recurrent cutaneous fungal infections (HP:0011370)2.82681584
28Volvulus (HP:0002580)2.82145628
29Gingival bleeding (HP:0000225)2.75979344
30Subacute progressive viral hepatitis (HP:0006572)2.72765456
31Abnormality of the prostate (HP:0008775)2.68380674
32Recurrent pneumonia (HP:0006532)2.63161957
33Arterial thrombosis (HP:0004420)2.61880078
34Pulmonary infiltrates (HP:0002113)2.50647386
35Obstructive lung disease (HP:0006536)2.49786743
36Chronic obstructive pulmonary disease (HP:0006510)2.49786743
37Viral hepatitis (HP:0006562)2.49679767
38Osteolytic defects of the hand bones (HP:0009699)2.47730862
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.47730862
40Thick nail (HP:0001805)2.45797318
41Tetraparesis (HP:0002273)2.44521117
42Chronic diarrhea (HP:0002028)2.42964524
43Abnormality of chromosome stability (HP:0003220)2.42749694
44Recurrent lower respiratory tract infections (HP:0002783)2.42441739
45Genetic anticipation (HP:0003743)2.41815242
46Deep philtrum (HP:0002002)2.41682202
47Increased IgM level (HP:0003496)2.40857813
48Prominent nose (HP:0000448)2.39461511
49Systemic lupus erythematosus (HP:0002725)2.39404052
50Peritonitis (HP:0002586)2.36554890
51Osteomyelitis (HP:0002754)2.33316856
52Keratoconjunctivitis sicca (HP:0001097)2.32280821
53Vacuolated lymphocytes (HP:0001922)2.32156584
54Myocardial infarction (HP:0001658)2.29793494
55Autoimmune hemolytic anemia (HP:0001890)2.29440756
56Abnormality of T cells (HP:0002843)2.28950771
57Absent frontal sinuses (HP:0002688)2.25955726
58Meningitis (HP:0001287)2.24656334
59Premature loss of primary teeth (HP:0006323)2.22324125
60Transitional cell carcinoma of the bladder (HP:0006740)2.21683603
61Macroorchidism (HP:0000053)2.21377272
62Eosinophilia (HP:0001880)2.17914120
63Pustule (HP:0200039)2.17727292
64Joint hemorrhage (HP:0005261)2.16941056
65Hemoptysis (HP:0002105)2.15802040
66Cellulitis (HP:0100658)2.12983709
67Prolonged bleeding time (HP:0003010)2.12849962
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.12027814
69Bladder carcinoma (HP:0002862)2.11487439
70Bladder neoplasm (HP:0009725)2.11487439
71Asymmetry of the thorax (HP:0001555)2.11382720
72Keratoconjunctivitis (HP:0001096)2.11243604
73Alveolar cell carcinoma (HP:0006519)2.09408340
74Thyroid carcinoma (HP:0002890)2.09204804
75Recurrent bronchitis (HP:0002837)2.08170824
76Clubbing of toes (HP:0100760)2.07836306
77Narrow palate (HP:0000189)2.06516241
78Hematochezia (HP:0002573)2.06352583
79Hypergammaglobulinemia (HP:0010702)2.05278038
80Abnormality of B cell number (HP:0010975)2.03901181
81Stomach cancer (HP:0012126)2.02046140
82Bone pain (HP:0002653)2.01256972
83IgM deficiency (HP:0002850)2.00700551
84Acute lymphatic leukemia (HP:0006721)2.00147680
85Spinal cord lesions (HP:0100561)2.00144384
86Syringomyelia (HP:0003396)2.00144384
87Leukocytosis (HP:0001974)1.99730648
88IgA deficiency (HP:0002720)1.99540525
89Papilledema (HP:0001085)1.95805469
90B lymphocytopenia (HP:0010976)1.94213638
91Abnormality of T cell physiology (HP:0011840)1.93920290
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93025115
93Abnormality of the nasal septum (HP:0000419)1.93007363
94Vertebral compression fractures (HP:0002953)1.92810017
95Gastrointestinal infarctions (HP:0005244)1.91837708
96Rhabdomyosarcoma (HP:0002859)1.89814279
97Cheilitis (HP:0100825)1.89475062
98Low anterior hairline (HP:0000294)1.89467650
99Vertebral arch anomaly (HP:0008438)1.89090984
100Interstitial pulmonary disease (HP:0006530)1.87686841
101Nephritis (HP:0000123)1.87418275
102Porencephaly (HP:0002132)1.87036714
103Stomatitis (HP:0010280)1.86655556
104Abnormality of incisor morphology (HP:0011063)1.86199769
105Anal stenosis (HP:0002025)1.86096724
106Plagiocephaly (HP:0001357)1.85292592
107Progressive inability to walk (HP:0002505)1.84952625
108Thrombocytosis (HP:0001894)1.84129792
109Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83994950
110Granulocytopenia (HP:0001913)1.83356437
111Poikiloderma (HP:0001029)1.83181674
112Inflammation of the large intestine (HP:0002037)1.83138918
113Abnormality of the endocardium (HP:0004306)1.82783218
114Overgrowth (HP:0001548)1.82624724
115Acute myeloid leukemia (HP:0004808)1.82499264
116Neoplasm of the tracheobronchial system (HP:0100552)1.82442290
117Renal cortical cysts (HP:0000803)1.81849810
118Epistaxis (HP:0000421)1.81848758
119Nasal polyposis (HP:0100582)1.81826463
120Spontaneous hematomas (HP:0007420)1.81801221
121Chronic sinusitis (HP:0011109)1.81413892
122Abnormality of the fingertips (HP:0001211)1.80913897
123Agammaglobulinemia (HP:0004432)1.80668559
124Spondylolisthesis (HP:0003302)1.80198233
125Abnormality of T cell number (HP:0011839)1.79902880
126Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79881316
127Medulloblastoma (HP:0002885)1.79737862
128Abnormality of the pleura (HP:0002103)1.79436265
129Arterial tortuosity (HP:0005116)1.78572975
130Abnormality of the pericardium (HP:0001697)1.78482695
131Abnormality of the frontal sinuses (HP:0002687)1.77977819
132Panhypogammaglobulinemia (HP:0003139)1.77922082
133Encephalitis (HP:0002383)1.77898787
134Abnormal auditory evoked potentials (HP:0006958)1.77647226
135Albinism (HP:0001022)1.76964930
136Bronchitis (HP:0012387)1.76951612
137Abnormal platelet volume (HP:0011876)1.75267924
138Thyroiditis (HP:0100646)1.74337305
139Colitis (HP:0002583)1.74064398
140Bruising susceptibility (HP:0000978)1.73835455
141Thoracolumbar scoliosis (HP:0002944)1.73623356
142Petechiae (HP:0000967)1.73183938
143Menstrual irregularities (HP:0000858)1.72903671
144Abnormality of the peritoneum (HP:0002585)1.72600508
145Glomerulopathy (HP:0100820)1.72005583
146Gangrene (HP:0100758)1.71986011
147Persistence of primary teeth (HP:0006335)1.70154987
148Curly hair (HP:0002212)1.68861174
149Micronodular cirrhosis (HP:0001413)1.67157017
150Somatic mutation (HP:0001428)1.66342235
151Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65505399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.46520378
2TYK23.22840860
3IRAK42.79355853
4IKBKE2.75274399
5TXK2.65816404
6BLK2.54713673
7JAK32.52004075
8TBK12.46296081
9IRAK32.34221262
10KIT2.28141152
11IKBKB2.12058770
12* JAK12.06968217
13ZAK1.81854619
14NEK91.81577501
15TEC1.81030868
16MAP4K11.80234743
17EIF2AK31.80066096
18TRIM281.79727603
19FGFR41.74535319
20EPHA31.74138098
21MAP3K131.67566544
22FGFR31.65285444
23FRK1.64231021
24ACVR1B1.61495710
25CHUK1.60587686
26TRPM71.59144792
27TGFBR21.55028895
28CAMK1D1.53656369
29RIPK41.52199711
30NUAK11.51493862
31TAOK31.50702329
32MELK1.44100910
33PBK1.42044935
34BCR1.40338593
35CDK121.36662901
36SIK31.33869409
37PIM21.27892545
38YES11.27454524
39TNIK1.23016309
40INSRR1.22246162
41STK31.20514416
42CSK1.20163762
43HCK1.14090515
44CSF1R1.13011576
45STK38L1.12482260
46AKT31.11374057
47BTK1.05951649
48PIM11.03828741
49ZAP701.02299883
50SYK1.01869471
51STK40.99374739
52LYN0.99032375
53IRAK10.96859840
54PIK3CG0.94203323
55BRSK20.93138833
56* EIF2AK20.91719393
57LCK0.90366595
58MAP3K20.89807185
59PIK3CA0.89806583
60TSSK60.88825209
61TIE10.83153855
62RPS6KA40.83153807
63ERN10.82553740
64MARK30.81849707
65BMPR20.81705609
66WNK10.81682401
67SIK10.80205907
68EPHB10.75956907
69STK100.75804911
70FGFR20.74911254
71PDGFRA0.74106967
72CAMK1G0.74041748
73NLK0.73635841
74BRD40.71853339
75SCYL20.71698511
76JAK20.71097075
77TAF10.70098592
78MKNK20.69499597
79RPS6KB20.69092238
80TTN0.68767216
81ERBB30.68183948
82ITK0.68126819
83MAP2K30.66641540
84MST1R0.66059915
85STK380.64499425
86PRKAA20.63293388
87CAMKK20.62466403
88ABL10.61825445
89MATK0.61010353
90ATR0.60822471
91HIPK20.60733750
92BMX0.60281737
93MAP3K60.60202394
94GRK10.58828686
95PRPF4B0.58514061
96LATS10.58505491
97PRKCQ0.58428718
98MST40.57312177
99FLT30.56714058
100BMPR1B0.55824851
101CDC70.55026605
102ADRBK20.52794069
103FER0.52706773
104CDK60.52548002
105SIK20.52387955
106STK240.51684564
107RIPK10.50988419
108MAP3K30.50652185
109CLK10.50098116
110RPS6KA50.49904378
111PTK60.47312138
112STK390.47215844
113MAP3K100.46983918
114EIF2AK10.46351674
115FGR0.45466503
116SGK20.44535547
117GRK70.44459188
118IRAK20.41965717
119PRKG20.40867092
120EGFR0.40742168
121TGFBR10.40615651
122PRKCD0.40511327
123MAP3K50.39667286
124DDR20.39145861
125IGF1R0.39042588
126SGK30.38913236
127CDC42BPA0.38672870
128PTK2B0.38623466
129KSR10.38441804
130CDK40.37851972
131TNK20.37715141
132PLK40.36231738
133FGFR10.35755416
134MAPK110.34446261
135INSR0.33055544
136MKNK10.32368218
137PDGFRB0.32288508

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.86345427
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85597513
3Leishmaniasis_Homo sapiens_hsa051402.70730058
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64964258
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.61385219
6Allograft rejection_Homo sapiens_hsa053302.59506207
7Graft-versus-host disease_Homo sapiens_hsa053322.53582845
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.52180921
9* Measles_Homo sapiens_hsa051622.50254715
10Staphylococcus aureus infection_Homo sapiens_hsa051502.30160097
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18813294
12Malaria_Homo sapiens_hsa051442.17854005
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14769177
14* Influenza A_Homo sapiens_hsa051642.07257102
15* Herpes simplex infection_Homo sapiens_hsa051682.01395242
16Osteoclast differentiation_Homo sapiens_hsa043801.99155965
17TNF signaling pathway_Homo sapiens_hsa046681.93586041
18Legionellosis_Homo sapiens_hsa051341.82711782
19Autoimmune thyroid disease_Homo sapiens_hsa053201.73797837
20Hematopoietic cell lineage_Homo sapiens_hsa046401.71305823
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68737825
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.61353603
23Pertussis_Homo sapiens_hsa051331.60742504
24Caffeine metabolism_Homo sapiens_hsa002321.59032354
25Toxoplasmosis_Homo sapiens_hsa051451.57974782
26Primary immunodeficiency_Homo sapiens_hsa053401.57797244
27Rheumatoid arthritis_Homo sapiens_hsa053231.53266516
28Tuberculosis_Homo sapiens_hsa051521.52948092
29Asthma_Homo sapiens_hsa053101.46964357
30Antigen processing and presentation_Homo sapiens_hsa046121.35770748
31Dorso-ventral axis formation_Homo sapiens_hsa043201.35319611
32Apoptosis_Homo sapiens_hsa042101.30140712
33African trypanosomiasis_Homo sapiens_hsa051431.29203826
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24286261
35Hepatitis B_Homo sapiens_hsa051611.22764044
36Type I diabetes mellitus_Homo sapiens_hsa049401.21909708
37* Hepatitis C_Homo sapiens_hsa051601.21062643
38B cell receptor signaling pathway_Homo sapiens_hsa046621.20064658
39Viral myocarditis_Homo sapiens_hsa054161.18067158
40Chemokine signaling pathway_Homo sapiens_hsa040621.12660651
41Salmonella infection_Homo sapiens_hsa051321.12070150
42Phagosome_Homo sapiens_hsa041451.12018247
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10024833
44Small cell lung cancer_Homo sapiens_hsa052221.06700187
45Non-small cell lung cancer_Homo sapiens_hsa052231.05585286
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05191468
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.02620362
48Renal cell carcinoma_Homo sapiens_hsa052110.96798643
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96317648
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96264643
51Other glycan degradation_Homo sapiens_hsa005110.94180634
52Shigellosis_Homo sapiens_hsa051310.85115881
53Complement and coagulation cascades_Homo sapiens_hsa046100.84394151
54Amoebiasis_Homo sapiens_hsa051460.80782905
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80170764
56ABC transporters_Homo sapiens_hsa020100.80016680
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.79455014
58Lysosome_Homo sapiens_hsa041420.79162534
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78560587
60ECM-receptor interaction_Homo sapiens_hsa045120.78396340
61Inositol phosphate metabolism_Homo sapiens_hsa005620.73481390
62p53 signaling pathway_Homo sapiens_hsa041150.72067143
63Glioma_Homo sapiens_hsa052140.72043560
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71455959
65Prolactin signaling pathway_Homo sapiens_hsa049170.71344484
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69687823
67Endometrial cancer_Homo sapiens_hsa052130.69259828
68One carbon pool by folate_Homo sapiens_hsa006700.69015833
69mTOR signaling pathway_Homo sapiens_hsa041500.68290623
70Chronic myeloid leukemia_Homo sapiens_hsa052200.68182562
71Colorectal cancer_Homo sapiens_hsa052100.68004190
72Pancreatic cancer_Homo sapiens_hsa052120.66940478
73Acute myeloid leukemia_Homo sapiens_hsa052210.66448475
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66322519
75Fanconi anemia pathway_Homo sapiens_hsa034600.66284280
76Systemic lupus erythematosus_Homo sapiens_hsa053220.65367556
77T cell receptor signaling pathway_Homo sapiens_hsa046600.64771350
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.63102062
79Non-homologous end-joining_Homo sapiens_hsa034500.63077522
80Thyroid cancer_Homo sapiens_hsa052160.62801407
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62249160
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61151967
83MicroRNAs in cancer_Homo sapiens_hsa052060.57946475
84Platelet activation_Homo sapiens_hsa046110.57850873
85Pathways in cancer_Homo sapiens_hsa052000.56009370
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.55686647
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52916372
88* Viral carcinogenesis_Homo sapiens_hsa052030.52286291
89ErbB signaling pathway_Homo sapiens_hsa040120.51440735
90Vitamin digestion and absorption_Homo sapiens_hsa049770.50762607
91Adherens junction_Homo sapiens_hsa045200.50341146
92Renin-angiotensin system_Homo sapiens_hsa046140.50165701
93Insulin resistance_Homo sapiens_hsa049310.49496706
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48037945
95HTLV-I infection_Homo sapiens_hsa051660.47880529
96Focal adhesion_Homo sapiens_hsa045100.46788084
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46027327
98Proteoglycans in cancer_Homo sapiens_hsa052050.44468927
99Bladder cancer_Homo sapiens_hsa052190.44266257
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43924688
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43459513
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42521292
103Estrogen signaling pathway_Homo sapiens_hsa049150.42181881
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40934081
105Lysine degradation_Homo sapiens_hsa003100.40146674
106Cell cycle_Homo sapiens_hsa041100.39919199
107Choline metabolism in cancer_Homo sapiens_hsa052310.39710078
108Arachidonic acid metabolism_Homo sapiens_hsa005900.39588161
109Type II diabetes mellitus_Homo sapiens_hsa049300.39143566
110HIF-1 signaling pathway_Homo sapiens_hsa040660.38620571
111Prostate cancer_Homo sapiens_hsa052150.38450799
112TGF-beta signaling pathway_Homo sapiens_hsa043500.38386187
113* Epstein-Barr virus infection_Homo sapiens_hsa051690.38360656
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37137690
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.36918114
116Fatty acid biosynthesis_Homo sapiens_hsa000610.36718303
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33477643
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33027136
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32897459
120Notch signaling pathway_Homo sapiens_hsa043300.31790119
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.31424876
122Melanoma_Homo sapiens_hsa052180.30761583
123FoxO signaling pathway_Homo sapiens_hsa040680.30695320
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29835384
125Mineral absorption_Homo sapiens_hsa049780.29193183
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.28751129
127Homologous recombination_Homo sapiens_hsa034400.27889867

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