EIF2AK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.75425336
2COPI coating of Golgi vesicle (GO:0048205)5.75425336
3intestinal cholesterol absorption (GO:0030299)5.53729960
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.22301162
5* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.79977652
6exocrine pancreas development (GO:0031017)4.72684733
7protein retention in ER lumen (GO:0006621)4.62614023
8* positive regulation of nuclease activity (GO:0032075)4.60224748
9nuclear pore complex assembly (GO:0051292)4.46032518
10antigen processing and presentation of endogenous antigen (GO:0019883)4.44157881
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43048954
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43048954
13* regulation of nuclease activity (GO:0032069)4.20576033
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.16357661
15CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.15578082
16* endoplasmic reticulum unfolded protein response (GO:0030968)4.12703684
17COPII vesicle coating (GO:0048208)4.05400565
18histone H3-K36 demethylation (GO:0070544)4.04091460
19regulation of gamma-delta T cell differentiation (GO:0045586)4.00348497
20* cellular response to unfolded protein (GO:0034620)3.99391904
21* ER-nucleus signaling pathway (GO:0006984)3.85833812
22positive regulation of gamma-delta T cell activation (GO:0046645)3.85651265
23nuclear pore organization (GO:0006999)3.74213114
24T cell lineage commitment (GO:0002360)3.72064616
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.71299411
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70541455
27* cellular response to topologically incorrect protein (GO:0035967)3.66860573
28* response to endoplasmic reticulum stress (GO:0034976)3.62116593
29germinal center formation (GO:0002467)3.61795556
30positive regulation of histone deacetylation (GO:0031065)3.57070988
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.55731980
32cellular response to ethanol (GO:0071361)3.55317175
33B cell homeostasis (GO:0001782)3.53459610
34B cell receptor signaling pathway (GO:0050853)3.51778789
35regulation of gamma-delta T cell activation (GO:0046643)3.51242844
36positive thymic T cell selection (GO:0045059)3.48777289
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48535045
38vesicle coating (GO:0006901)3.43750070
39protein localization to endosome (GO:0036010)3.34884143
40intestinal absorption (GO:0050892)3.33679457
41digestion (GO:0007586)3.31336656
42B cell proliferation (GO:0042100)3.27419287
43negative regulation of bone resorption (GO:0045779)3.23301021
44pore complex assembly (GO:0046931)3.22642049
45transcytosis (GO:0045056)3.19557705
46mannose metabolic process (GO:0006013)3.16445081
47T cell migration (GO:0072678)3.14209578
48* response to unfolded protein (GO:0006986)3.02560566
49intestinal epithelial cell development (GO:0060576)3.02484439
50response to muramyl dipeptide (GO:0032495)2.99048247
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.96138100
52positive regulation of tolerance induction (GO:0002645)2.94536757
53cytoplasmic mRNA processing body assembly (GO:0033962)2.93343333
54L-serine transport (GO:0015825)2.93306667
55peptidyl-asparagine modification (GO:0018196)2.92135676
56protein N-linked glycosylation via asparagine (GO:0018279)2.91717355
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91272581
58* endocrine pancreas development (GO:0031018)2.91101425
59L-alpha-amino acid transmembrane transport (GO:1902475)2.91063943
60UDP-N-acetylglucosamine metabolic process (GO:0006047)2.90686435
614-hydroxyproline metabolic process (GO:0019471)2.88008135
62serine transport (GO:0032329)2.86988718
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86267897
64positive T cell selection (GO:0043368)2.86012124
65regulation of RNA export from nucleus (GO:0046831)2.85649845
66glomerular epithelial cell development (GO:0072310)2.85266915
67positive regulation of Rap GTPase activity (GO:0032854)2.84742801
68* response to topologically incorrect protein (GO:0035966)2.83078902
69embryonic process involved in female pregnancy (GO:0060136)2.82061297
70negative regulation of B cell proliferation (GO:0030889)2.81165205
71gonadal mesoderm development (GO:0007506)2.80657448
72cellular response to antibiotic (GO:0071236)2.78451890
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77686662
74positive regulation of protein homooligomerization (GO:0032464)2.77482571
75regulation of B cell proliferation (GO:0030888)2.75183545
76myelin maintenance (GO:0043217)2.73851092
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73091773
78tolerance induction (GO:0002507)2.71942154
79negative regulation of humoral immune response (GO:0002921)2.70206223
80protein targeting to Golgi (GO:0000042)2.67071548
81protein N-linked glycosylation (GO:0006487)2.65622246
82positive regulation of glycogen biosynthetic process (GO:0045725)2.64073028
83valine metabolic process (GO:0006573)2.62973895
84peptidyl-proline hydroxylation (GO:0019511)2.61468407
85positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60908468
86histone lysine demethylation (GO:0070076)2.60506211
87interleukin-6-mediated signaling pathway (GO:0070102)2.59015621
88Golgi organization (GO:0007030)2.58402565
89response to type I interferon (GO:0034340)2.57798865
90positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.57457595
91regulation of histone H3-K27 methylation (GO:0061085)2.57347037
92positive regulation of interferon-alpha production (GO:0032727)2.57292018
93positive regulation of B cell differentiation (GO:0045579)2.56446956
94regulation of extracellular matrix disassembly (GO:0010715)2.56382083
95cellular response to type I interferon (GO:0071357)2.56343307
96type I interferon signaling pathway (GO:0060337)2.56343307
97retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56175176
98regulation of nucleobase-containing compound transport (GO:0032239)2.54328360
99negative regulation of bone remodeling (GO:0046851)2.52924093
100positive regulation of protein oligomerization (GO:0032461)2.52142108
101regulation of cholesterol homeostasis (GO:2000188)2.51831408
102activation of MAPKKK activity (GO:0000185)2.51424209
103vesicle targeting (GO:0006903)2.51242906
104regulation of B cell receptor signaling pathway (GO:0050855)2.50145860
105sequestering of metal ion (GO:0051238)2.48911864
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.48808383
107establishment of protein localization to Golgi (GO:0072600)2.48310403
108negative regulation of cell killing (GO:0031342)2.48027912
109negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48027912
110Rap protein signal transduction (GO:0032486)2.47910500
111histone demethylation (GO:0016577)2.47659187
112positive regulation of p38MAPK cascade (GO:1900745)2.47317234
113regulation of fibroblast apoptotic process (GO:2000269)2.47145219
114regulation of interferon-alpha production (GO:0032647)2.45917277
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45686162
116macroautophagy (GO:0016236)2.45243444
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44866971
118interferon-gamma-mediated signaling pathway (GO:0060333)2.44852020
119growth hormone receptor signaling pathway (GO:0060396)2.44785177
120immunoglobulin mediated immune response (GO:0016064)2.44336441
121* ER overload response (GO:0006983)2.43261398
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42386106
123positive regulation of B cell proliferation (GO:0030890)2.41660653
124regulation of tolerance induction (GO:0002643)2.40785116
125negative thymic T cell selection (GO:0045060)2.39685487
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.39029553
127cellular response to glucose starvation (GO:0042149)2.37405050
128NIK/NF-kappaB signaling (GO:0038061)2.37374350
129regulation of ARF protein signal transduction (GO:0032012)2.36782666
130receptor catabolic process (GO:0032801)2.35776300
131intra-Golgi vesicle-mediated transport (GO:0006891)2.35519543
132apoptotic cell clearance (GO:0043277)2.35371418
133stress granule assembly (GO:0034063)2.35327846
134response to laminar fluid shear stress (GO:0034616)2.35227857
135regulation of transforming growth factor beta2 production (GO:0032909)2.34378977
136myeloid dendritic cell differentiation (GO:0043011)2.33918639
137response to peptidoglycan (GO:0032494)2.33322030
138regulation of Golgi to plasma membrane protein transport (GO:0042996)2.32889513
139histone H3-K9 demethylation (GO:0033169)2.32861726
140zinc ion transport (GO:0006829)2.32677607
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31768106
142response to interleukin-15 (GO:0070672)2.31654470
143germ cell migration (GO:0008354)2.31388242
144hepatocyte apoptotic process (GO:0097284)2.31072064
145lymphocyte homeostasis (GO:0002260)2.30703749
146regulation of T-helper 1 cell differentiation (GO:0045625)2.30451545
147platelet-derived growth factor receptor signaling pathway (GO:0048008)2.30431770
148positive regulation of interleukin-2 production (GO:0032743)2.30122797
149regulation of interleukin-12 biosynthetic process (GO:0045075)2.29757582
150protein maturation by protein folding (GO:0022417)2.29538286
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.29352764
152regulation of interferon-beta biosynthetic process (GO:0045357)2.29260770
153sphingosine metabolic process (GO:0006670)2.28373269
154negative T cell selection (GO:0043383)2.28305107
155protein hydroxylation (GO:0018126)2.25970453
156V(D)J recombination (GO:0033151)2.24517113
157myeloid dendritic cell activation (GO:0001773)2.24399840
158negative regulation of fatty acid transport (GO:2000192)2.24209238
159positive regulation of DNA-templated transcription, initiation (GO:2000144)2.23895274
160detection of other organism (GO:0098543)2.21068975
161T cell costimulation (GO:0031295)2.19877054
162positive regulation of developmental pigmentation (GO:0048087)2.19851548
163cellular response to interleukin-15 (GO:0071350)2.19286718
164antigen receptor-mediated signaling pathway (GO:0050851)2.18512119
165positive regulation of humoral immune response (GO:0002922)2.18298303
166T cell homeostasis (GO:0043029)2.18054740
167regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.16563187
168negative regulation of thymocyte apoptotic process (GO:0070244)2.16063813
169oligosaccharide catabolic process (GO:0009313)2.15166293
170lymphocyte costimulation (GO:0031294)2.14935569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.58035412
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.70000079
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.49482766
4MYC_22102868_ChIP-Seq_BL_Human3.18104144
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84047971
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77477105
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.75829931
8RUNX_20019798_ChIP-Seq_JUKART_Human2.51495606
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44357297
10GATA1_22025678_ChIP-Seq_K562_Human2.43049077
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.40696016
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.36445535
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25934492
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17992047
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11473109
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07890501
17CLOCK_20551151_ChIP-Seq_293T_Human2.07212388
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.05939897
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.97066632
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95327278
21TCF7_22412390_ChIP-Seq_EML_Mouse1.92521432
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.90900409
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88096830
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88063682
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.87849500
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85813303
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.83534610
28KDM2B_26808549_Chip-Seq_DND41_Human1.79126213
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75455324
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.75053640
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.70749785
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68329410
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68218340
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68029174
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66820894
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66504949
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66504949
38MYB_26560356_Chip-Seq_TH2_Human1.65345516
39* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64015977
40* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62594370
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61604124
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61104307
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.60972459
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60801950
45* IRF8_27001747_Chip-Seq_BMDM_Mouse1.60019418
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59631218
47FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.58578175
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.57274148
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55775915
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55520445
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.55445174
52* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53884596
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53662594
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51534981
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50769309
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50658446
57* VDR_21846776_ChIP-Seq_THP-1_Human1.48537535
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.45916377
59UTX_26944678_Chip-Seq_JUKART_Human1.44895002
60SPI1_23127762_ChIP-Seq_K562_Human1.41309659
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41113560
62* VDR_24763502_ChIP-Seq_THP-1_Human1.39839397
63GATA6_25053715_ChIP-Seq_YYC3_Human1.35467067
64MYB_26560356_Chip-Seq_TH1_Human1.34742653
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33480801
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32563225
67MAF_26560356_Chip-Seq_TH1_Human1.31907739
68* GATA3_27048872_Chip-Seq_THYMUS_Human1.31080311
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31005866
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.30628721
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29147014
72* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28738411
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26189639
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.24383579
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23803453
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23548039
77* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23409661
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20966723
79PU_27001747_Chip-Seq_BMDM_Mouse1.20881351
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.20528287
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19720402
82* KDM2B_26808549_Chip-Seq_K562_Human1.19654011
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.18507537
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17771218
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17771018
86E2F7_22180533_ChIP-Seq_HELA_Human1.17381852
87SCL_19346495_ChIP-Seq_HPC-7_Human1.17293040
88TFEB_21752829_ChIP-Seq_HELA_Human1.16544134
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15000094
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14876522
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14205095
92FOXA1_25552417_ChIP-Seq_VCAP_Human1.13989296
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13888460
94GATA1_19941826_ChIP-Seq_K562_Human1.12775758
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11149790
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11108020
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10045143
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09513826
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07575996
100SPI1_23547873_ChIP-Seq_NB4_Human1.07434758
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07073574
102GATA4_25053715_ChIP-Seq_YYC3_Human1.06771174
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05932486
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05338525
105NCOR1_26117541_ChIP-Seq_K562_Human1.03136957
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02866290
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02650806
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02451441
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02313120
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02124488
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.01410859
112VDR_24787735_ChIP-Seq_THP-1_Human1.01191525
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00718171
114GATA2_19941826_ChIP-Seq_K562_Human1.00269714
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00010352
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98978295
117* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98077900
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.97770227
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97218685
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96378080
121AHR_22903824_ChIP-Seq_MCF-7_Human0.96310007
122CIITA_25753668_ChIP-Seq_RAJI_Human0.95277744
123* ATF3_27146783_Chip-Seq_COLON_Human0.95039921
124* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94442479
125* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94022487
126RACK7_27058665_Chip-Seq_MCF-7_Human0.93773996
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.93253747
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93036461
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91125531
130CHD1_26751641_Chip-Seq_LNCaP_Human0.89413333
131BRD4_25478319_ChIP-Seq_HGPS_Human0.89361987
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88373075
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.88341613
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87705141
135* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87595568
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.85819155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer4.04226298
2MP0010234_abnormal_vibrissa_follicle3.53077269
3* MP0001666_abnormal_nutrient_absorption3.43320756
4MP0005083_abnormal_biliary_tract3.08267121
5MP0002877_abnormal_melanocyte_morpholog3.03653528
6MP0008057_abnormal_DNA_replication2.99170888
7* MP0005220_abnormal_exocrine_pancreas2.75161711
8MP0005076_abnormal_cell_differentiation2.74699531
9MP0005365_abnormal_bile_salt2.74648235
10MP0004264_abnormal_extraembryonic_tissu2.55419705
11MP0003303_peritoneal_inflammation2.44921565
12MP0005451_abnormal_body_composition2.34190248
13MP0002138_abnormal_hepatobiliary_system2.32682475
14MP0002009_preneoplasia2.27623607
15MP0003705_abnormal_hypodermis_morpholog2.16412336
16MP0006054_spinal_hemorrhage2.15730620
17* MP0002693_abnormal_pancreas_physiology2.13754744
18* MP0001944_abnormal_pancreas_morphology2.04293034
19MP0008961_abnormal_basal_metabolism2.02575161
20MP0009780_abnormal_chondrocyte_physiolo2.02221579
21MP0001790_abnormal_immune_system1.96472847
22MP0005387_immune_system_phenotype1.96472847
23MP0002166_altered_tumor_susceptibility1.96079623
24MP0002139_abnormal_hepatobiliary_system1.88706481
25MP0003045_fibrosis1.82504700
26MP0005671_abnormal_response_to1.81722393
27* MP0003868_abnormal_feces_composition1.78146806
28MP0001800_abnormal_humoral_immune1.75896675
29MP0004185_abnormal_adipocyte_glucose1.68418331
30MP0010352_gastrointestinal_tract_polyps1.65818516
31MP0002909_abnormal_adrenal_gland1.65589798
32MP0003183_abnormal_peptide_metabolism1.63685446
33MP0005310_abnormal_salivary_gland1.62396999
34MP0000013_abnormal_adipose_tissue1.61479965
35MP0009785_altered_susceptibility_to1.59352764
36MP0002928_abnormal_bile_duct1.58201896
37MP0003252_abnormal_bile_duct1.57416128
38MP0003172_abnormal_lysosome_physiology1.56490398
39MP0000685_abnormal_immune_system1.54375026
40MP0000003_abnormal_adipose_tissue1.53978094
41MP0004947_skin_inflammation1.52361398
42MP0003566_abnormal_cell_adhesion1.45858037
43MP0002396_abnormal_hematopoietic_system1.43548710
44MP0009384_cardiac_valve_regurgitation1.38964793
45MP0003283_abnormal_digestive_organ1.38812673
46MP0005085_abnormal_gallbladder_physiolo1.36602758
47MP0002254_reproductive_system_inflammat1.35660333
48MP0005025_abnormal_response_to1.33762467
49MP0008438_abnormal_cutaneous_collagen1.33160795
50MP0002148_abnormal_hypersensitivity_rea1.30980837
51MP0003091_abnormal_cell_migration1.30748144
52MP0002722_abnormal_immune_system1.28828410
53MP0005058_abnormal_lysosome_morphology1.27857243
54MP0002452_abnormal_antigen_presenting1.27537962
55MP0004043_abnormal_pH_regulation1.25604991
56MP0005375_adipose_tissue_phenotype1.24127402
57MP0002168_other_aberrant_phenotype1.22697058
58MP0002429_abnormal_blood_cell1.20960446
59MP0001835_abnormal_antigen_presentation1.20834266
60MP0009643_abnormal_urine_homeostasis1.19744786
61MP0003866_abnormal_defecation1.16727173
62MP0000609_abnormal_liver_physiology1.14325677
63MP0005000_abnormal_immune_tolerance1.14110585
64MP0005360_urolithiasis1.13885048
65MP0003941_abnormal_skin_development1.13244867
66* MP0002078_abnormal_glucose_homeostasis1.12474409
67MP0002420_abnormal_adaptive_immunity1.07599789
68* MP0002998_abnormal_bone_remodeling1.07445661
69MP0008004_abnormal_stomach_pH1.06274419
70MP0010094_abnormal_chromosome_stability1.05554620
71MP0000858_altered_metastatic_potential1.04722724
72MP0001873_stomach_inflammation1.04662754
73MP0005257_abnormal_intraocular_pressure1.04455796
74MP0003221_abnormal_cardiomyocyte_apopto1.03555250
75MP0002723_abnormal_immune_serum1.02839591
76MP0001819_abnormal_immune_cell1.01653093
77MP0003950_abnormal_plasma_membrane1.01570524
78MP0003191_abnormal_cellular_cholesterol1.00164875
79MP0003890_abnormal_embryonic-extraembry0.99090188
80* MP0001845_abnormal_inflammatory_respons0.98993018
81MP0002136_abnormal_kidney_physiology0.98185568
82MP0004808_abnormal_hematopoietic_stem0.98061795
83MP0003436_decreased_susceptibility_to0.97873870
84MP0010678_abnormal_skin_adnexa0.97433248
85MP0009333_abnormal_splenocyte_physiolog0.97030279
86MP0010155_abnormal_intestine_physiology0.96289743
87MP0005666_abnormal_adipose_tissue0.95590040
88MP0005023_abnormal_wound_healing0.95384320
89MP0003828_pulmonary_edema0.95239396
90MP0003656_abnormal_erythrocyte_physiolo0.95068772
91MP0002118_abnormal_lipid_homeostasis0.94813623
92MP0004381_abnormal_hair_follicle0.93680880
93MP0002006_tumorigenesis0.93217440
94* MP0002896_abnormal_bone_mineralization0.92856607
95MP0002933_joint_inflammation0.91392288
96MP0002398_abnormal_bone_marrow0.89813482
97MP0003195_calcinosis0.89555041
98MP0003453_abnormal_keratinocyte_physiol0.89484108
99MP0005084_abnormal_gallbladder_morpholo0.88273742
100MP0002132_abnormal_respiratory_system0.87940342
101MP0001915_intracranial_hemorrhage0.86993391
102MP0001216_abnormal_epidermal_layer0.84632872
103MP0002060_abnormal_skin_morphology0.83597455
104MP0000716_abnormal_immune_system0.83455641
105MP0010329_abnormal_lipoprotein_level0.83444393
106MP0001853_heart_inflammation0.82677864
107MP0000689_abnormal_spleen_morphology0.82276948
108MP0000703_abnormal_thymus_morphology0.82050352
109MP0000462_abnormal_digestive_system0.80764142
110MP0005623_abnormal_meninges_morphology0.80087314
111MP0001879_abnormal_lymphatic_vessel0.79633727
112MP0002019_abnormal_tumor_incidence0.79232055
113* MP0003795_abnormal_bone_structure0.78764315
114MP0010307_abnormal_tumor_latency0.78739289
115MP0003959_abnormal_lean_body0.78652093
116MP0001849_ear_inflammation0.78610820
117MP0001765_abnormal_ion_homeostasis0.76045780
118MP0009115_abnormal_fat_cell0.75902019
119MP0000350_abnormal_cell_proliferation0.75519315
120MP0009703_decreased_birth_body0.75134618
121MP0001851_eye_inflammation0.74002932
122MP0008007_abnormal_cellular_replicative0.73621033
123MP0003763_abnormal_thymus_physiology0.73170594
124MP0005670_abnormal_white_adipose0.72200998
125MP0001299_abnormal_eye_distance/0.72153225
126MP0005381_digestive/alimentary_phenotyp0.72120700
127MP0000490_abnormal_crypts_of0.72023790
128MP0000465_gastrointestinal_hemorrhage0.71783739
129MP0002086_abnormal_extraembryonic_tissu0.71556455
130MP0006082_CNS_inflammation0.70839236
131* MP0005621_abnormal_cell_physiology0.70620687
132MP0002876_abnormal_thyroid_physiology0.70414739
133MP0001756_abnormal_urination0.69577077
134MP0001663_abnormal_digestive_system0.68885538
135MP0002405_respiratory_system_inflammati0.68188479
136MP0009840_abnormal_foam_cell0.68077514
137MP0002088_abnormal_embryonic_growth/wei0.67423654
138MP0001191_abnormal_skin_condition0.67078513
139MP0003077_abnormal_cell_cycle0.66987117
140MP0002419_abnormal_innate_immunity0.66916686
141MP0005164_abnormal_response_to0.66691602
142MP0004782_abnormal_surfactant_physiolog0.66677303
143MP0000371_diluted_coat_color0.66525914

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)3.75541686
2Papilloma (HP:0012740)3.34502430
3Verrucae (HP:0200043)3.34502430
4Agammaglobulinemia (HP:0004432)3.23192176
5Recurrent sinusitis (HP:0011108)3.11888391
6Cellulitis (HP:0100658)3.09838795
7Macroorchidism (HP:0000053)3.09583793
8Chronic diarrhea (HP:0002028)3.08907367
9Cerebral aneurysm (HP:0004944)3.08545227
10Autoimmune hemolytic anemia (HP:0001890)3.05098709
11Urinary glycosaminoglycan excretion (HP:0003541)2.99578661
12Mucopolysacchariduria (HP:0008155)2.99578661
13Thyroiditis (HP:0100646)2.89561173
14Colitis (HP:0002583)2.87095470
15Tetraparesis (HP:0002273)2.85634493
16Mitral stenosis (HP:0001718)2.84362707
17Recurrent viral infections (HP:0004429)2.83542869
18Dysostosis multiplex (HP:0000943)2.80965875
19Abnormality of B cell number (HP:0010975)2.76866516
20B lymphocytopenia (HP:0010976)2.76866516
21Mediastinal lymphadenopathy (HP:0100721)2.75232151
22T lymphocytopenia (HP:0005403)2.74539833
23Aortic aneurysm (HP:0004942)2.72746965
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72719711
25Abnormality of polysaccharide metabolism (HP:0011012)2.72719711
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72719711
27Eosinophilia (HP:0001880)2.66400218
28Mitral valve prolapse (HP:0001634)2.63539923
29Biliary tract neoplasm (HP:0100574)2.60293755
30Vasculitis (HP:0002633)2.60293479
31Hypoglycemic seizures (HP:0002173)2.57713283
32Subacute progressive viral hepatitis (HP:0006572)2.52427659
33Asymmetry of the thorax (HP:0001555)2.52403420
34IgG deficiency (HP:0004315)2.52042893
35Abnormality of the fingertips (HP:0001211)2.51230007
36Abnormality of T cell number (HP:0011839)2.48780385
37Hyperinsulinemic hypoglycemia (HP:0000825)2.47105628
38Gastrointestinal inflammation (HP:0004386)2.46764319
39Inflammation of the large intestine (HP:0002037)2.46002376
40Papillary thyroid carcinoma (HP:0002895)2.40836683
41Abnormality of cells of the lymphoid lineage (HP:0012140)2.40179558
42Hypoplasia of the thymus (HP:0000778)2.38283287
43Severe combined immunodeficiency (HP:0004430)2.36764118
44Overlapping toe (HP:0001845)2.36403545
45Increased CSF protein (HP:0002922)2.34702672
46Abnormality of T cells (HP:0002843)2.34636922
47Gastrointestinal stroma tumor (HP:0100723)2.34017359
48Curly hair (HP:0002212)2.32724169
49Flat acetabular roof (HP:0003180)2.30935553
50Myocardial infarction (HP:0001658)2.30516500
51Ulnar bowing (HP:0003031)2.29664598
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29322706
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28641395
54Basal cell carcinoma (HP:0002671)2.27503465
55Thoracolumbar scoliosis (HP:0002944)2.26943659
56Granulocytopenia (HP:0001913)2.25295788
57Syringomyelia (HP:0003396)2.24615620
58Spinal cord lesions (HP:0100561)2.24615620
59Papilledema (HP:0001085)2.21769933
60Combined immunodeficiency (HP:0005387)2.19702386
61Recurrent pneumonia (HP:0006532)2.19551751
62Bronchitis (HP:0012387)2.17248563
63Arterial tortuosity (HP:0005116)2.13502386
64Dilatation of the ascending aorta (HP:0005111)2.13423955
65Disproportionate tall stature (HP:0001519)2.13401716
66Lymphoma (HP:0002665)2.12709833
67Fatigue (HP:0012378)2.12510217
68Abnormality of the intrinsic pathway (HP:0010989)2.11348144
69* Abnormality of endocrine pancreas physiology (HP:0012093)2.10289770
70* Abnormality of the pancreatic islet cells (HP:0006476)2.10289770
71Ankyloglossia (HP:0010296)2.09064846
72Eczematoid dermatitis (HP:0000976)2.08480948
73Pancreatic islet-cell hyperplasia (HP:0004510)2.08013334
74Severe short stature (HP:0003510)2.07437194
75Abnormality of the common coagulation pathway (HP:0010990)2.05908213
76Deep philtrum (HP:0002002)2.05011172
77Recurrent lower respiratory tract infections (HP:0002783)2.03906257
78Vertebral arch anomaly (HP:0008438)2.03666395
79Enlarged penis (HP:0000040)2.02336504
80Aneurysm (HP:0002617)2.01996529
81Resting tremor (HP:0002322)2.00903670
82Symptomatic seizures (HP:0011145)2.00814683
83Abnormality of eosinophils (HP:0001879)1.99558187
84Recurrent bronchitis (HP:0002837)1.99151533
85Fat malabsorption (HP:0002630)1.99094175
86Interstitial pulmonary disease (HP:0006530)1.98861285
87Hematochezia (HP:0002573)1.98765639
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.98613267
89Gout (HP:0001997)1.96903199
90Recurrent cutaneous fungal infections (HP:0011370)1.96821157
91Chronic mucocutaneous candidiasis (HP:0002728)1.96821157
92Squamous cell carcinoma (HP:0002860)1.96323582
93Lower limb hyperreflexia (HP:0002395)1.94591985
94Abnormal biliary tract morphology (HP:0012440)1.93524942
95Abnormality of oral frenula (HP:0000190)1.90220226
96Transitional cell carcinoma of the bladder (HP:0006740)1.88888202
97Emphysema (HP:0002097)1.88205762
98Osteomyelitis (HP:0002754)1.86322075
99Hyperglycemia (HP:0003074)1.85917076
100Cervical subluxation (HP:0003308)1.85867075
101Ketoacidosis (HP:0001993)1.85862826
102Cutaneous melanoma (HP:0012056)1.85523437
103Spondylolisthesis (HP:0003302)1.84843105
104IgM deficiency (HP:0002850)1.84593833
105Abnormality of macrophages (HP:0004311)1.84525123
106* Small epiphyses (HP:0010585)1.84504436
107Hepatitis (HP:0012115)1.81956027
108Panhypogammaglobulinemia (HP:0003139)1.81866009
109Vascular tortuosity (HP:0004948)1.81628825
110Vertebral clefting (HP:0008428)1.81421679
111Autoimmune thrombocytopenia (HP:0001973)1.81377025
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81364818
113Cubitus valgus (HP:0002967)1.81102283
114Viral hepatitis (HP:0006562)1.80579659
115Striae distensae (HP:0001065)1.80220986
116Somatic mutation (HP:0001428)1.78841357
117Recurrent fungal infections (HP:0002841)1.78712246
118Abnormality of the gastric mucosa (HP:0004295)1.76460010
119Abnormality of the lumbar spine (HP:0100712)1.75738433
120Neoplasm of the tracheobronchial system (HP:0100552)1.75711797
121Thyroid carcinoma (HP:0002890)1.75053605
122Uterine leiomyosarcoma (HP:0002891)1.74123996
123Leiomyosarcoma (HP:0100243)1.74123996
124Recurrent otitis media (HP:0000403)1.74024324
125Lymphopenia (HP:0001888)1.73837407
126Sepsis (HP:0100806)1.73797274
127Restrictive lung disease (HP:0002091)1.72547606
128Hypoglycemic coma (HP:0001325)1.72528717
129Abdominal distention (HP:0003270)1.71853088
130Bladder neoplasm (HP:0009725)1.71473114
131Bladder carcinoma (HP:0002862)1.71473114
132Pulmonary infiltrates (HP:0002113)1.71159955
133Coarse hair (HP:0002208)1.69952981
134Hypoproteinemia (HP:0003075)1.69365643
135Micronodular cirrhosis (HP:0001413)1.68104935
136Hand muscle atrophy (HP:0009130)1.68077639
137Abnormality of the prostate (HP:0008775)1.66708932
138Xerostomia (HP:0000217)1.65639158
139* Exocrine pancreatic insufficiency (HP:0001738)1.64944755
140Tibial bowing (HP:0002982)1.64905747
141Abnormality of T cell physiology (HP:0011840)1.63932269
142Hyperkalemia (HP:0002153)1.63676520
143Gastrointestinal carcinoma (HP:0002672)1.62490728
144Malignant gastrointestinal tract tumors (HP:0006749)1.62490728
145Arterial thrombosis (HP:0004420)1.62463643
146Right ventricular cardiomyopathy (HP:0011663)1.61818889
147Conjugated hyperbilirubinemia (HP:0002908)1.61741073
148Thoracic kyphosis (HP:0002942)1.61245937
149Cortical dysplasia (HP:0002539)1.61041865
150Steatorrhea (HP:0002570)1.60419546
151Abnormality of the peritoneum (HP:0002585)1.60208255
152Abnormality of the thoracic spine (HP:0100711)1.60139744
153Insulin-resistant diabetes mellitus (HP:0000831)1.60125610
154Aortic dissection (HP:0002647)1.59588912
155Glomerulosclerosis (HP:0000096)1.59565367
156Meningitis (HP:0001287)1.58979702
157Lymphedema (HP:0001004)1.58974939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.23858830
2PRPF4B3.88129362
3MAP3K103.50734611
4FRK3.08815806
5TRIB32.93864817
6NTRK12.52501621
7SIK12.41860441
8TAOK32.31919406
9NEK92.28097959
10MAP4K12.26317483
11GRK62.25844969
12EEF2K2.19429099
13PKN22.07842913
14MAP3K21.96946454
15INSRR1.92156066
16PTK61.90021691
17NLK1.88281647
18IKBKE1.81973790
19CDK121.75927568
20BMPR21.74928928
21STK241.66451010
22JAK11.56771651
23LRRK21.52030864
24SIK31.52022214
25STK101.51937401
26SCYL21.50786623
27EPHB11.44764422
28TRPM71.44528177
29HIPK21.37974777
30LATS11.36238662
31AKT31.35054150
32TBK11.34324042
33CAMK1G1.30529191
34CAMK1D1.28936648
35IKBKB1.28373089
36TGFBR21.25559445
37IRAK41.19795751
38RIPK41.19296662
39KSR11.18691134
40MET1.17742963
41ITK1.15016196
42YES11.14673635
43PDGFRB1.12952618
44STK38L1.12102519
45BLK1.11276937
46CSF1R1.10086730
47FGFR31.09826870
48TYK21.08140629
49FGFR21.08121896
50BRD41.05810874
51SMG11.03073912
52PRKCH1.01837921
53FGFR41.01589084
54MAPK110.99023481
55BTK0.98735857
56IRAK30.98714592
57MTOR0.96894206
58MST40.95559782
59PDGFRA0.94379722
60MAP3K10.91444105
61CDK60.89980975
62CDK40.89578326
63EPHA20.89566690
64PASK0.88200543
65RPS6KB10.88174800
66MST1R0.87146302
67RIPK10.86051709
68ALK0.83544873
69NEK60.82617284
70BCKDK0.82507147
71PIK3CG0.80879748
72LATS20.78908618
73STK390.78735309
74MAP3K70.78575591
75PTK20.77837520
76ZAP700.77091280
77CSK0.76621643
78SGK30.75039047
79STK30.74986971
80BMX0.74701038
81RET0.74679462
82JAK20.74435556
83HCK0.72581397
84CHUK0.71979065
85CLK10.70806364
86EPHA30.69929538
87MAP3K30.69860516
88SYK0.68864363
89MAPKAPK30.68734967
90TEC0.67014762
91CDC42BPA0.65956039
92MARK30.65514339
93DYRK1B0.65187370
94LYN0.62596629
95EGFR0.60745775
96MAP3K50.59725435
97PDK10.59437789
98PDPK10.59336993
99MAP2K20.59009887
100IRAK10.58016745
101PIM10.57990931
102INSR0.57955513
103JAK30.57390314
104CDK80.56656223
105MKNK20.56221644
106TNIK0.55483825
107MELK0.55405816
108MAPK70.54515837
109FLT30.54479726
110PRKCQ0.53264739
111PRKD10.53206342
112SIK20.50146573
113WNK10.49505830
114ABL10.49105820
115STK110.48615302
116PAK30.48477382
117CDK90.48300096
118RAF10.48189162
119MAPK150.46783795
120KSR20.46741583
121MATK0.46519316
122SGK4940.46413360
123SGK2230.46413360
124MAP3K90.45947833
125BRSK20.44987758
126PIK3CA0.43827277
127NUAK10.43616172
128PRKAA10.43253802
129MAP3K140.43196981
130MAP3K130.42445798
131MAP2K10.42361633
132MAP3K80.41848414
133DMPK0.41092546
134PRKD20.40519485
135MOS0.40149373
136LCK0.40099435
137MARK20.40022214
138FGR0.39545837
139FYN0.38568318
140ICK0.38483236
141GSK3A0.38013813
142RPS6KB20.37791659
143SGK20.36502649

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.59076642
2Pancreatic secretion_Homo sapiens_hsa049722.78955418
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.51000335
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.40914168
5Allograft rejection_Homo sapiens_hsa053302.31044747
6B cell receptor signaling pathway_Homo sapiens_hsa046622.22583663
7Autoimmune thyroid disease_Homo sapiens_hsa053202.15302209
8Protein digestion and absorption_Homo sapiens_hsa049742.12471058
9Graft-versus-host disease_Homo sapiens_hsa053322.11638534
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00156749
11Fat digestion and absorption_Homo sapiens_hsa049751.98371712
12Type I diabetes mellitus_Homo sapiens_hsa049401.82167515
13Primary immunodeficiency_Homo sapiens_hsa053401.77225281
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75872750
15Asthma_Homo sapiens_hsa053101.71377385
16Leishmaniasis_Homo sapiens_hsa051401.69816047
17Protein export_Homo sapiens_hsa030601.67452526
18* Influenza A_Homo sapiens_hsa051641.64342257
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64073347
20Viral myocarditis_Homo sapiens_hsa054161.61121013
21Type II diabetes mellitus_Homo sapiens_hsa049301.53963279
22* Measles_Homo sapiens_hsa051621.53190345
23Chronic myeloid leukemia_Homo sapiens_hsa052201.50727887
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44287022
25N-Glycan biosynthesis_Homo sapiens_hsa005101.41861390
26* Herpes simplex infection_Homo sapiens_hsa051681.36657933
27* Apoptosis_Homo sapiens_hsa042101.34074365
28Insulin resistance_Homo sapiens_hsa049311.32146545
29mTOR signaling pathway_Homo sapiens_hsa041501.31075216
30Non-small cell lung cancer_Homo sapiens_hsa052231.28605377
31Staphylococcus aureus infection_Homo sapiens_hsa051501.26969713
32Dorso-ventral axis formation_Homo sapiens_hsa043201.26208076
33Sulfur metabolism_Homo sapiens_hsa009201.25108007
34Pancreatic cancer_Homo sapiens_hsa052121.21514325
35Insulin secretion_Homo sapiens_hsa049111.17907315
36Osteoclast differentiation_Homo sapiens_hsa043801.17033279
37Systemic lupus erythematosus_Homo sapiens_hsa053221.16193069
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15222684
39Prostate cancer_Homo sapiens_hsa052151.14243831
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13633949
41Estrogen signaling pathway_Homo sapiens_hsa049151.13262146
42Renal cell carcinoma_Homo sapiens_hsa052111.13210702
43Thyroid cancer_Homo sapiens_hsa052161.13041174
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12081712
45Glycerolipid metabolism_Homo sapiens_hsa005611.11676257
46Nitrogen metabolism_Homo sapiens_hsa009101.11656621
47* Hepatitis C_Homo sapiens_hsa051601.10021426
48Thyroid hormone synthesis_Homo sapiens_hsa049181.09727949
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09501596
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08843894
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08534447
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.07420018
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.06433483
54Lysosome_Homo sapiens_hsa041421.05578066
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03962013
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03226501
57Endometrial cancer_Homo sapiens_hsa052131.01496177
58Lysine degradation_Homo sapiens_hsa003101.01008267
59Glioma_Homo sapiens_hsa052141.00985431
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.96654547
61T cell receptor signaling pathway_Homo sapiens_hsa046600.93480885
62p53 signaling pathway_Homo sapiens_hsa041150.89873923
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.87970735
64Prolactin signaling pathway_Homo sapiens_hsa049170.87696493
65Antigen processing and presentation_Homo sapiens_hsa046120.86914037
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86850378
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86360615
68FoxO signaling pathway_Homo sapiens_hsa040680.86092671
69Inositol phosphate metabolism_Homo sapiens_hsa005620.85569742
70Selenocompound metabolism_Homo sapiens_hsa004500.85137123
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84628188
72Small cell lung cancer_Homo sapiens_hsa052220.83469021
73HTLV-I infection_Homo sapiens_hsa051660.83252491
74Focal adhesion_Homo sapiens_hsa045100.82903517
75Bladder cancer_Homo sapiens_hsa052190.82314875
76Chemokine signaling pathway_Homo sapiens_hsa040620.81497499
77Renin-angiotensin system_Homo sapiens_hsa046140.79807603
78Legionellosis_Homo sapiens_hsa051340.79565199
79Other glycan degradation_Homo sapiens_hsa005110.78276865
80Toxoplasmosis_Homo sapiens_hsa051450.77379870
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77331030
82ErbB signaling pathway_Homo sapiens_hsa040120.77252789
83Proteoglycans in cancer_Homo sapiens_hsa052050.77041797
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76965314
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.74815207
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74587625
87Adherens junction_Homo sapiens_hsa045200.73744904
88* Epstein-Barr virus infection_Homo sapiens_hsa051690.72222975
89MicroRNAs in cancer_Homo sapiens_hsa052060.72029384
90Acute myeloid leukemia_Homo sapiens_hsa052210.71969373
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71938629
92Rheumatoid arthritis_Homo sapiens_hsa053230.70605607
93AMPK signaling pathway_Homo sapiens_hsa041520.70566521
94Platelet activation_Homo sapiens_hsa046110.70055306
95Hepatitis B_Homo sapiens_hsa051610.69827252
96Viral carcinogenesis_Homo sapiens_hsa052030.68344149
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67137379
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67017077
99Choline metabolism in cancer_Homo sapiens_hsa052310.65651236
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64303784
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63349642
102Insulin signaling pathway_Homo sapiens_hsa049100.63237546
103VEGF signaling pathway_Homo sapiens_hsa043700.62716481
104ECM-receptor interaction_Homo sapiens_hsa045120.62241549
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61628575
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.61509703
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61061566
108Hematopoietic cell lineage_Homo sapiens_hsa046400.60385715
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.60341796
110Non-homologous end-joining_Homo sapiens_hsa034500.59626876
111ABC transporters_Homo sapiens_hsa020100.58863338
112Vitamin digestion and absorption_Homo sapiens_hsa049770.57279367
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.56818024
114Cocaine addiction_Homo sapiens_hsa050300.56636519
115Vibrio cholerae infection_Homo sapiens_hsa051100.55353434
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55200464
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55150932
118Bile secretion_Homo sapiens_hsa049760.54999184
119Shigellosis_Homo sapiens_hsa051310.54801766
120Glucagon signaling pathway_Homo sapiens_hsa049220.53738081
121Colorectal cancer_Homo sapiens_hsa052100.53097632
122Amoebiasis_Homo sapiens_hsa051460.52516482
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52503746
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51749741
125Malaria_Homo sapiens_hsa051440.51585938
126Endocytosis_Homo sapiens_hsa041440.51207700
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48407988
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48298721
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47644860
130TNF signaling pathway_Homo sapiens_hsa046680.46333526
131Pertussis_Homo sapiens_hsa051330.44685731
132Circadian rhythm_Homo sapiens_hsa047100.42739156
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42202968
134Tuberculosis_Homo sapiens_hsa051520.41676801
135MAPK signaling pathway_Homo sapiens_hsa040100.41431349
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.40890685
137Sphingolipid metabolism_Homo sapiens_hsa006000.40827566
138Complement and coagulation cascades_Homo sapiens_hsa046100.40194430

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