EIF2AK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.76978537
2regulation of gene silencing by RNA (GO:0060966)4.61284212
3regulation of posttranscriptional gene silencing (GO:0060147)4.61284212
4regulation of gene silencing by miRNA (GO:0060964)4.61284212
5negative regulation of histone methylation (GO:0031061)4.44428703
6protein localization to kinetochore (GO:0034501)4.16637872
7nuclear pore complex assembly (GO:0051292)4.08222322
8mitotic sister chromatid cohesion (GO:0007064)3.94007654
9pre-miRNA processing (GO:0031054)3.93513671
10histone H3-K4 trimethylation (GO:0080182)3.91635774
11secondary heart field specification (GO:0003139)3.89032951
12heart field specification (GO:0003128)3.89032951
13positive regulation of gene expression, epigenetic (GO:0045815)3.88081213
14nuclear pore organization (GO:0006999)3.86768852
15regulation of translational termination (GO:0006449)3.82522647
16establishment of integrated proviral latency (GO:0075713)3.73958812
17dosage compensation (GO:0007549)3.73511942
18DNA unwinding involved in DNA replication (GO:0006268)3.70459568
19histone mRNA catabolic process (GO:0071044)3.67520905
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60505738
21hemidesmosome assembly (GO:0031581)3.57860482
22mitotic nuclear envelope disassembly (GO:0007077)3.51110867
23cytoplasmic mRNA processing body assembly (GO:0033962)3.41166918
24protein localization to chromosome, centromeric region (GO:0071459)3.39310758
25regulation of translational fidelity (GO:0006450)3.37373286
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.35077244
27protein complex localization (GO:0031503)3.34547826
28folic acid-containing compound biosynthetic process (GO:0009396)3.33131077
29IMP biosynthetic process (GO:0006188)3.31146656
30nuclear envelope disassembly (GO:0051081)3.30649211
31membrane disassembly (GO:0030397)3.30649211
32heterochromatin organization (GO:0070828)3.30614358
33L-serine metabolic process (GO:0006563)3.26973521
34regulation of histone H3-K9 methylation (GO:0051570)3.23046021
35peptidyl-lysine trimethylation (GO:0018023)3.20881424
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19626369
37cell adhesion mediated by integrin (GO:0033627)3.19513053
38DNA geometric change (GO:0032392)3.19457130
39endodermal cell differentiation (GO:0035987)3.18667679
40establishment of apical/basal cell polarity (GO:0035089)3.17616254
41cell-substrate junction assembly (GO:0007044)3.14023018
42DNA duplex unwinding (GO:0032508)3.13414003
43negative regulation of chondrocyte differentiation (GO:0032331)3.13337262
44protein-DNA complex disassembly (GO:0032986)3.12537544
45nucleosome disassembly (GO:0006337)3.12537544
46cell migration involved in sprouting angiogenesis (GO:0002042)3.11228074
47G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.09443495
48regulation of cell fate specification (GO:0042659)3.06996613
49notochord development (GO:0030903)3.06297429
50chondrocyte proliferation (GO:0035988)3.05632492
51hippo signaling (GO:0035329)3.05285929
52definitive hemopoiesis (GO:0060216)3.04636934
53histone H3-K4 methylation (GO:0051568)3.03916066
54chromatin assembly (GO:0031497)3.03517849
55pore complex assembly (GO:0046931)3.03497552
56mitotic chromosome condensation (GO:0007076)3.01844465
57endothelial cell morphogenesis (GO:0001886)3.00838782
58positive regulation of gamma-delta T cell activation (GO:0046645)2.99396641
59negative regulation of fibroblast apoptotic process (GO:2000270)2.97516362
60convergent extension (GO:0060026)2.97391003
61regulation of hippo signaling (GO:0035330)2.96289129
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94754200
63histone H3-K9 methylation (GO:0051567)2.94489408
64IMP metabolic process (GO:0046040)2.94036854
65corticosteroid receptor signaling pathway (GO:0031958)2.93697130
66collagen fibril organization (GO:0030199)2.91164201
67monoubiquitinated protein deubiquitination (GO:0035520)2.90800217
68mesodermal cell differentiation (GO:0048333)2.89475509
69histone H3-K36 demethylation (GO:0070544)2.88932860
70negative regulation of histone modification (GO:0031057)2.88640852
71positive regulation of catenin import into nucleus (GO:0035413)2.88622338
72positive regulation of histone deacetylation (GO:0031065)2.87774815
73skin morphogenesis (GO:0043589)2.87143382
74cellular protein complex localization (GO:0034629)2.86106883
75adherens junction assembly (GO:0034333)2.83444042
76formation of translation preinitiation complex (GO:0001731)2.80653333
77NIK/NF-kappaB signaling (GO:0038061)2.80490873
78cell-substrate adherens junction assembly (GO:0007045)2.79710037
79focal adhesion assembly (GO:0048041)2.79710037
80negative regulation of chromatin modification (GO:1903309)2.79155871
81regulation of interferon-beta biosynthetic process (GO:0045357)2.78957739
82glomerular visceral epithelial cell development (GO:0072015)2.78141685
83negative regulation of erythrocyte differentiation (GO:0045647)2.75318107
84establishment of viral latency (GO:0019043)2.75126999
85COPI coating of Golgi vesicle (GO:0048205)2.71318462
86Golgi transport vesicle coating (GO:0048200)2.71318462
87regulation of SMAD protein import into nucleus (GO:0060390)2.70817015
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70816438
89regulation of integrin activation (GO:0033623)2.70790700
90negative regulation of DNA repair (GO:0045738)2.69372873
91protein localization to endosome (GO:0036010)2.69258616
92positive regulation of B cell differentiation (GO:0045579)2.68145174
93mRNA stabilization (GO:0048255)2.67907907
94RNA stabilization (GO:0043489)2.67907907
95regulation of histone H3-K4 methylation (GO:0051569)2.66796048
96pinocytosis (GO:0006907)2.66037836
97regulation of chromatin silencing (GO:0031935)2.65863670
98mitotic metaphase plate congression (GO:0007080)2.64653821
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.64234949
100regulation of establishment of planar polarity (GO:0090175)2.64205506
101negative regulation of granulocyte differentiation (GO:0030853)2.62790284
102anterior/posterior axis specification, embryo (GO:0008595)2.61672679
103NLS-bearing protein import into nucleus (GO:0006607)2.61376329
104regulation of sister chromatid cohesion (GO:0007063)2.60972852
105chromatin assembly or disassembly (GO:0006333)2.60200369
106sister chromatid segregation (GO:0000819)2.59952939
107metaphase plate congression (GO:0051310)2.59873182
108lung-associated mesenchyme development (GO:0060484)2.57983597
109gap junction assembly (GO:0016264)2.57696955
110positive regulation of histone H3-K4 methylation (GO:0051571)2.55691962
111regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54988479
112histone H3-K9 modification (GO:0061647)2.54708303
1133-UTR-mediated mRNA stabilization (GO:0070935)2.53925607
114regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.52337112
115basement membrane organization (GO:0071711)2.51997824
116peptidyl-lysine methylation (GO:0018022)2.50870705
117histone lysine methylation (GO:0034968)2.50532777
118mRNA splice site selection (GO:0006376)2.50342635
119bone trabecula formation (GO:0060346)2.50079840
120meiotic chromosome segregation (GO:0045132)2.49364992
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46968977
122regulation of histone methylation (GO:0031060)2.46796008
123regulation of histone H3-K27 methylation (GO:0061085)2.46057665
124peptidyl-lysine dimethylation (GO:0018027)2.46035236
125regulation of RNA export from nucleus (GO:0046831)2.45602469
126negative regulation of histone acetylation (GO:0035067)2.45427136
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45314289
128protein retention in ER lumen (GO:0006621)2.44210944
129histone-serine phosphorylation (GO:0035404)2.43833109
130DNA conformation change (GO:0071103)2.42771166
131cardiac ventricle formation (GO:0003211)2.42463267
132establishment of monopolar cell polarity (GO:0061162)2.42017873
133establishment or maintenance of monopolar cell polarity (GO:0061339)2.42017873
134COPII vesicle coating (GO:0048208)2.41141928
135glucocorticoid receptor signaling pathway (GO:0042921)2.40396611
136negative regulation of androgen receptor signaling pathway (GO:0060766)2.40255753
137regulation of catenin import into nucleus (GO:0035412)2.39871332
138regulation of mitotic spindle organization (GO:0060236)2.39299487
139negative regulation of cell fate specification (GO:0009996)2.38828394
140histone methylation (GO:0016571)2.38281922
141regulation of spindle organization (GO:0090224)2.38191094
142response to UV-C (GO:0010225)2.38119503
143inner cell mass cell proliferation (GO:0001833)2.37752918
144mitotic cytokinesis (GO:0000281)2.37386980
145peptidyl-arginine omega-N-methylation (GO:0035247)2.37268476
146epithelial cell-cell adhesion (GO:0090136)2.36920299
147nuclear envelope organization (GO:0006998)2.36745295
148retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36232438
149substrate adhesion-dependent cell spreading (GO:0034446)2.35158524
150natural killer cell differentiation (GO:0001779)2.34951974
151regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.34847639
152specification of organ identity (GO:0010092)2.34671783
153muscle cell migration (GO:0014812)2.34049224
154nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.33954669
155mitotic sister chromatid segregation (GO:0000070)2.33684833
156regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.33535540
157regulation of gene silencing (GO:0060968)2.33294170
158positive regulation of neuroblast proliferation (GO:0002052)2.33119156
159positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.33044394
160mesenchymal-epithelial cell signaling (GO:0060638)2.32989913
161positive regulation of SMAD protein import into nucleus (GO:0060391)2.32315881
162histone phosphorylation (GO:0016572)2.32011080
163hypotonic response (GO:0006971)2.31937844
164blood vessel endothelial cell migration (GO:0043534)2.31763308
165vascular endothelial growth factor signaling pathway (GO:0038084)2.31112424
166alternative mRNA splicing, via spliceosome (GO:0000380)2.30004638
167maturation of SSU-rRNA (GO:0030490)2.29738899
168glomerular epithelial cell development (GO:0072310)2.28121759
169neural tube development (GO:0021915)2.27110348
170regulation of mammary gland epithelial cell proliferation (GO:0033599)2.26610720
171polarized epithelial cell differentiation (GO:0030859)2.26288581
172nucleotide-sugar biosynthetic process (GO:0009226)2.25645868
173regulation of nucleobase-containing compound transport (GO:0032239)2.24208574
174DNA strand elongation involved in DNA replication (GO:0006271)2.23434822
175osteoblast differentiation (GO:0001649)2.23410814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.07194058
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.87200364
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.60674593
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.87503220
5MYC_22102868_ChIP-Seq_BL_Human3.37952755
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12797526
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02371208
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56330940
9VDR_21846776_ChIP-Seq_THP-1_Human2.47956723
10SCL_19346495_ChIP-Seq_HPC-7_Human2.39891749
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.27975244
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25515395
13CLOCK_20551151_ChIP-Seq_293T_Human2.17587389
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16911902
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.12706492
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07821836
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05843256
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.05707878
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00331977
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00198366
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.97000143
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.95826144
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91647807
24TCF7_22412390_ChIP-Seq_EML_Mouse1.90784967
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90529429
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89525970
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.89006451
28ZNF263_19887448_ChIP-Seq_K562_Human1.88973722
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85505032
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83513310
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81870329
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81579914
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80905070
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80170530
35SPI1_23127762_ChIP-Seq_K562_Human1.78493378
36AR_21909140_ChIP-Seq_LNCAP_Human1.74184349
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72150011
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68704677
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66327728
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64222406
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64222406
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64222406
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.63723117
44CIITA_25753668_ChIP-Seq_RAJI_Human1.62264578
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62134193
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61605797
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61424105
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.60506663
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59004970
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58819138
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.57561032
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57181643
53KDM2B_26808549_Chip-Seq_DND41_Human1.54532274
54MYB_26560356_Chip-Seq_TH1_Human1.53388578
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53381389
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53128509
57MYB_26560356_Chip-Seq_TH2_Human1.50435949
58MAF_26560356_Chip-Seq_TH1_Human1.50265057
59* UTX_26944678_Chip-Seq_JUKART_Human1.48537174
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48338053
61TFEB_21752829_ChIP-Seq_HELA_Human1.47812531
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45863265
63VDR_24763502_ChIP-Seq_THP-1_Human1.45472762
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43772274
65IGF1R_20145208_ChIP-Seq_DFB_Human1.42964201
66SPI1_23547873_ChIP-Seq_NB4_Human1.42612112
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.40964146
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.40330797
69* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39870874
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39287158
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38459047
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.35711215
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35202486
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34907006
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32117586
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29647395
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29358666
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29058462
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28825432
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28496508
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28306659
82* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26857258
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26673861
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.26148369
85XRN2_22483619_ChIP-Seq_HELA_Human1.25351922
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24633391
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24570245
88TTF2_22483619_ChIP-Seq_HELA_Human1.24154146
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.22997515
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22818544
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22768415
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22748079
93KDM5A_27292631_Chip-Seq_BREAST_Human1.22619032
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22260075
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21670695
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21490671
97BRD4_25478319_ChIP-Seq_HGPS_Human1.20937562
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20862316
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20862316
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20431646
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19463162
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19102865
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19059541
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.18998913
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18478842
106CHD1_26751641_Chip-Seq_LNCaP_Human1.17937891
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15975938
108ATF3_27146783_Chip-Seq_COLON_Human1.15876134
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14048472
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.12697749
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12679500
112TP53_22127205_ChIP-Seq_IMR90_Human1.12505786
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12127437
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11034295
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.10923345
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10460663
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09635513
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09120256
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08915890
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08731095
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08623321
122* ELK1_19687146_ChIP-ChIP_HELA_Human1.08596640
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08254385
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08055135
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07905646
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06700706
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06666330
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06010424
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05911703
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05890715
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.05813855
132SOX2_16153702_ChIP-ChIP_HESCs_Human1.05430481
133STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05041123
134PU_27001747_Chip-Seq_BMDM_Mouse1.03568229
135EP300_21415370_ChIP-Seq_HL-1_Mouse1.03113479
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03006637
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02804514
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02724589
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02378640
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01614849
141P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00959590
142RUNX_20019798_ChIP-Seq_JUKART_Human1.00570239
143TP53_16413492_ChIP-PET_HCT116_Human0.99118427
144IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98859874
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98631731
146TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98557898
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97349023
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97329067
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97310934
150* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97169926
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97149416
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96794493
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96230033
154* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95642594
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94899074
156GATA3_27048872_Chip-Seq_THYMUS_Human0.94435104
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94257403
158DCP1A_22483619_ChIP-Seq_HELA_Human0.93832224
159* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93649083
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92884102
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.92047604
162* NCOR1_26117541_ChIP-Seq_K562_Human0.91069947
163EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90616444
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90434115
165* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89972228
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88497766
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.88378097
168E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87349392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.55599449
2MP0008438_abnormal_cutaneous_collagen4.33728718
3MP0003941_abnormal_skin_development3.73776135
4MP0004272_abnormal_basement_membrane3.63083181
5MP0002396_abnormal_hematopoietic_system3.03967192
6MP0003787_abnormal_imprinting2.91916550
7MP0003123_paternal_imprinting2.52299878
8MP0010307_abnormal_tumor_latency2.50956237
9MP0002254_reproductive_system_inflammat2.50688825
10MP0004808_abnormal_hematopoietic_stem2.42642218
11MP0005257_abnormal_intraocular_pressure2.35997530
12MP0003950_abnormal_plasma_membrane2.35739842
13MP0003121_genomic_imprinting2.33001167
14MP0005076_abnormal_cell_differentiation2.26690153
15MP0010094_abnormal_chromosome_stability2.22877324
16MP0009278_abnormal_bone_marrow2.19477747
17MP0003705_abnormal_hypodermis_morpholog2.19472405
18MP0003111_abnormal_nucleus_morphology2.17588406
19MP0010352_gastrointestinal_tract_polyps2.11237858
20MP0005275_abnormal_skin_tensile2.06711434
21MP0005174_abnormal_tail_pigmentation2.06022482
22MP0003693_abnormal_embryo_hatching2.04735675
23MP0008057_abnormal_DNA_replication1.95618873
24MP0003077_abnormal_cell_cycle1.93500511
25MP0005623_abnormal_meninges_morphology1.93302268
26MP0001299_abnormal_eye_distance/1.89213132
27MP0003303_peritoneal_inflammation1.86260917
28MP0003091_abnormal_cell_migration1.81444045
29MP0008877_abnormal_DNA_methylation1.79419220
30MP0001835_abnormal_antigen_presentation1.74356817
31MP0003300_gastrointestinal_ulcer1.73480959
32MP0009053_abnormal_anal_canal1.68712746
33MP0003937_abnormal_limbs/digits/tail_de1.66409704
34MP0000537_abnormal_urethra_morphology1.66362407
35MP0001915_intracranial_hemorrhage1.62219015
36MP0005397_hematopoietic_system_phenotyp1.61541903
37MP0001545_abnormal_hematopoietic_system1.61541903
38MP0004957_abnormal_blastocyst_morpholog1.61138291
39MP0004233_abnormal_muscle_weight1.60979914
40MP0008932_abnormal_embryonic_tissue1.59683710
41MP0005503_abnormal_tendon_morphology1.59675595
42MP0002697_abnormal_eye_size1.58697041
43MP0000762_abnormal_tongue_morphology1.58329731
44MP0003566_abnormal_cell_adhesion1.56379923
45MP0000350_abnormal_cell_proliferation1.54818904
46MP0003828_pulmonary_edema1.54144497
47MP0002086_abnormal_extraembryonic_tissu1.52761525
48MP0009697_abnormal_copulation1.52562521
49MP0003172_abnormal_lysosome_physiology1.51939897
50MP0002060_abnormal_skin_morphology1.51644602
51MP0008007_abnormal_cellular_replicative1.47805461
52MP0000685_abnormal_immune_system1.44535436
53MP0009384_cardiac_valve_regurgitation1.43596798
54MP0009672_abnormal_birth_weight1.41545918
55MP0001800_abnormal_humoral_immune1.41322490
56MP0001672_abnormal_embryogenesis/_devel1.41219749
57MP0005380_embryogenesis_phenotype1.41219749
58MP0002398_abnormal_bone_marrow1.39462516
59MP0003385_abnormal_body_wall1.37625547
60MP0002166_altered_tumor_susceptibility1.35892513
61MP0003984_embryonic_growth_retardation1.33253600
62MP0003890_abnormal_embryonic-extraembry1.33079647
63MP0000689_abnormal_spleen_morphology1.32116207
64* MP0002452_abnormal_antigen_presenting1.30851863
65MP0000371_diluted_coat_color1.30829725
66MP0003942_abnormal_urinary_system1.29444879
67MP0002088_abnormal_embryonic_growth/wei1.28852173
68MP0001697_abnormal_embryo_size1.27292893
69MP0002084_abnormal_developmental_patter1.26481745
70MP0000432_abnormal_head_morphology1.26273753
71MP0001879_abnormal_lymphatic_vessel1.25839139
72MP0001730_embryonic_growth_arrest1.23288374
73MP0000534_abnormal_ureter_morphology1.21721303
74MP0005621_abnormal_cell_physiology1.21248548
75MP0003755_abnormal_palate_morphology1.19374461
76MP0003115_abnormal_respiratory_system1.18308442
77MP0005508_abnormal_skeleton_morphology1.18120574
78MP0004197_abnormal_fetal_growth/weight/1.17714712
79MP0002928_abnormal_bile_duct1.16905798
80MP0009250_abnormal_appendicular_skeleto1.16330578
81MP0000490_abnormal_crypts_of1.16014902
82MP0001293_anophthalmia1.15531462
83MP0002722_abnormal_immune_system1.14815172
84MP0001286_abnormal_eye_development1.14709264
85MP0005464_abnormal_platelet_physiology1.13401577
86MP0001661_extended_life_span1.12126649
87MP0000703_abnormal_thymus_morphology1.11351186
88MP0004185_abnormal_adipocyte_glucose1.09980367
89MP0000733_abnormal_muscle_development1.09930404
90MP0002138_abnormal_hepatobiliary_system1.08328270
91MP0002080_prenatal_lethality1.08269456
92MP0004858_abnormal_nervous_system1.08156047
93MP0005387_immune_system_phenotype1.07871230
94MP0001790_abnormal_immune_system1.07871230
95MP0002089_abnormal_postnatal_growth/wei1.07751652
96MP0005409_darkened_coat_color1.06718918
97MP0002019_abnormal_tumor_incidence1.05982648
98MP0002111_abnormal_tail_morphology1.05514693
99MP0002085_abnormal_embryonic_tissue1.05329105
100MP0002925_abnormal_cardiovascular_devel1.05046411
101MP0000579_abnormal_nail_morphology1.04990942
102MP0002933_joint_inflammation1.04963070
103MP0006292_abnormal_olfactory_placode1.04739223
104MP0000049_abnormal_middle_ear1.03517567
105MP0002006_tumorigenesis1.03110577
106MP0002877_abnormal_melanocyte_morpholog1.01600768
107MP0002233_abnormal_nose_morphology1.01271726
108MP0002092_abnormal_eye_morphology0.99557684
109MP0000716_abnormal_immune_system0.98718774
110MP0009703_decreased_birth_body0.97495903
111MP0001873_stomach_inflammation0.97348400
112MP0002419_abnormal_innate_immunity0.97333584
113MP0003943_abnormal_hepatobiliary_system0.97149344
114MP0001958_emphysema0.96508511
115MP0002420_abnormal_adaptive_immunity0.95830074
116MP0002429_abnormal_blood_cell0.95518042
117MP0005197_abnormal_uvea_morphology0.95438664
118MP0010234_abnormal_vibrissa_follicle0.95023706
119MP0005384_cellular_phenotype0.94872745
120* MP0001819_abnormal_immune_cell0.94651066
121MP0006054_spinal_hemorrhage0.94566598
122* MP0002723_abnormal_immune_serum0.94139432
123MP0001849_ear_inflammation0.92514287
124MP0000467_abnormal_esophagus_morphology0.92318565
125MP0000015_abnormal_ear_pigmentation0.92189176
126MP0003315_abnormal_perineum_morphology0.91606359
127MP0005023_abnormal_wound_healing0.91257642
128MP0000767_abnormal_smooth_muscle0.90717661
129MP0000313_abnormal_cell_death0.90635957
130MP0002405_respiratory_system_inflammati0.90111588
131MP0003279_aneurysm0.88714856
132MP0008058_abnormal_DNA_repair0.87355313
133MP0009379_abnormal_foot_pigmentation0.86987958
134MP0002128_abnormal_blood_circulation0.86405494
135MP0010030_abnormal_orbit_morphology0.85079566
136MP0010368_abnormal_lymphatic_system0.84064181
137MP0002075_abnormal_coat/hair_pigmentati0.83392878
138MP0000465_gastrointestinal_hemorrhage0.83081526
139MP0000266_abnormal_heart_morphology0.83056756
140MP0003567_abnormal_fetal_cardiomyocyte0.82327716
141MP0002116_abnormal_craniofacial_bone0.81784969
142MP0002938_white_spotting0.80531085
143MP0002896_abnormal_bone_mineralization0.80415778
144MP0000751_myopathy0.80151149
145MP0003935_abnormal_craniofacial_develop0.79236590
146MP0002114_abnormal_axial_skeleton0.78939314
147MP0010630_abnormal_cardiac_muscle0.77782120
148MP0001243_abnormal_dermal_layer0.76023053
149MP0003283_abnormal_digestive_organ0.75252590
150MP0005501_abnormal_skin_physiology0.74717319
151MP0000428_abnormal_craniofacial_morphol0.73534903
152MP0008770_decreased_survivor_rate0.72991484
153MP0001853_heart_inflammation0.72181510
154* MP0000598_abnormal_liver_morphology0.71939067
155MP0003045_fibrosis0.71628709
156MP0004510_myositis0.71242977

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.51127300
2Protrusio acetabuli (HP:0003179)5.18767133
3Absent frontal sinuses (HP:0002688)3.53775082
4Abnormality of the fingertips (HP:0001211)3.30704673
5Aortic dissection (HP:0002647)3.19691364
6Atrophic scars (HP:0001075)3.06907202
7Abnormality of dentin (HP:0010299)3.03552811
8Vascular tortuosity (HP:0004948)3.03498714
9Arterial tortuosity (HP:0005116)3.01457571
10Volvulus (HP:0002580)2.96321399
11Chromsome breakage (HP:0040012)2.80313782
12Broad metatarsal (HP:0001783)2.77350618
13Soft skin (HP:0000977)2.69338807
14Spinal rigidity (HP:0003306)2.67419769
15Macroorchidism (HP:0000053)2.66300032
16Bladder diverticulum (HP:0000015)2.65344627
17Facial diplegia (HP:0001349)2.61668109
18Hypoplastic ischia (HP:0003175)2.59756743
19Spinal cord lesions (HP:0100561)2.58557916
20Syringomyelia (HP:0003396)2.58557916
21Coronal craniosynostosis (HP:0004440)2.58142959
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55294494
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54516797
24Fragile skin (HP:0001030)2.53379584
25Ulnar bowing (HP:0003031)2.52012716
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.51552202
27Increased density of long bones (HP:0006392)2.51331826
28Wormian bones (HP:0002645)2.49705804
29Selective tooth agenesis (HP:0001592)2.48178771
30Hematochezia (HP:0002573)2.46732477
31Hyperacusis (HP:0010780)2.39187485
32Blue sclerae (HP:0000592)2.39171999
33Follicular hyperkeratosis (HP:0007502)2.38774467
34Cerebral aneurysm (HP:0004944)2.36555423
35Disproportionate tall stature (HP:0001519)2.33660550
36Acute myeloid leukemia (HP:0004808)2.28869149
37Natal tooth (HP:0000695)2.28842783
38Genu recurvatum (HP:0002816)2.28525098
39Neonatal short-limb short stature (HP:0008921)2.27070955
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.27051906
41Narrow palate (HP:0000189)2.23438947
42Long eyelashes (HP:0000527)2.22476278
43Subacute progressive viral hepatitis (HP:0006572)2.17975561
44Broad thumb (HP:0011304)2.17109925
45Abnormality of the acetabulum (HP:0003170)2.15153490
46Abnormality of the thoracic spine (HP:0100711)2.14887281
47Radial bowing (HP:0002986)2.13822326
48Spastic diplegia (HP:0001264)2.10638344
49Sandal gap (HP:0001852)2.09981545
50Biconcave vertebral bodies (HP:0004586)2.08733535
51Abnormal delivery (HP:0001787)2.08383958
52Limited elbow extension (HP:0001377)2.07998557
53Urethral obstruction (HP:0000796)2.07689968
54Delayed cranial suture closure (HP:0000270)2.05742403
55Low anterior hairline (HP:0000294)2.05476740
56Osteolytic defects of the hand bones (HP:0009699)2.04387148
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.04387148
58Abnormality of the ischium (HP:0003174)2.03000246
59Epiphyseal dysplasia (HP:0002656)2.02894709
60Cellulitis (HP:0100658)2.01187468
61Abnormality of chromosome stability (HP:0003220)2.00833363
62Renal duplication (HP:0000075)1.99952183
63Ectopic kidney (HP:0000086)1.98354676
64Overgrowth (HP:0001548)1.97797172
65Elbow flexion contracture (HP:0002987)1.97617463
66Mitral valve prolapse (HP:0001634)1.96553382
67Vertebral compression fractures (HP:0002953)1.96194748
68High pitched voice (HP:0001620)1.95076783
69Aqueductal stenosis (HP:0002410)1.93616983
70Short 4th metacarpal (HP:0010044)1.93426826
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93426826
72Joint laxity (HP:0001388)1.92974678
73Protruding ear (HP:0000411)1.91121983
74Thrombocytosis (HP:0001894)1.90366997
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90273104
762-3 toe syndactyly (HP:0004691)1.90143222
77Shallow orbits (HP:0000586)1.90090233
78Pterygium (HP:0001059)1.89082783
79Myelodysplasia (HP:0002863)1.88399094
80Renovascular hypertension (HP:0100817)1.87624170
81Astrocytoma (HP:0009592)1.87297315
82Abnormality of the astrocytes (HP:0100707)1.87297315
83Obsessive-compulsive behavior (HP:0000722)1.86199351
84Facial hemangioma (HP:0000329)1.85468779
85Abnormality of the frontal sinuses (HP:0002687)1.85327472
86Aortic aneurysm (HP:0004942)1.85306548
87Skull defect (HP:0001362)1.85103551
88Arnold-Chiari malformation (HP:0002308)1.83355293
89Increased nuchal translucency (HP:0010880)1.82317488
90Delayed closure of the anterior fontanelle (HP:0001476)1.81658456
91Abnormality of the calcaneus (HP:0008364)1.81518525
92Ankyloglossia (HP:0010296)1.80785534
93Broad phalanges of the hand (HP:0009768)1.80570619
94Truncal obesity (HP:0001956)1.79472669
95Clubbing of toes (HP:0100760)1.79257349
96Type 1 muscle fiber predominance (HP:0003803)1.78935454
97Facial cleft (HP:0002006)1.78114859
98Premature skin wrinkling (HP:0100678)1.77084311
99Breech presentation (HP:0001623)1.76168969
100Wide anterior fontanel (HP:0000260)1.76057949
101Acute lymphatic leukemia (HP:0006721)1.75885840
102Thoracic kyphosis (HP:0002942)1.75864924
103Elfin facies (HP:0004428)1.75305226
104Ependymoma (HP:0002888)1.75168227
105Hyperextensible skin (HP:0000974)1.75073549
106High anterior hairline (HP:0009890)1.74541364
107Choanal stenosis (HP:0000452)1.73954987
108Entropion (HP:0000621)1.73895456
109Advanced eruption of teeth (HP:0006288)1.73140700
110Cutis marmorata (HP:0000965)1.72770750
111Flat cornea (HP:0007720)1.72314295
112Prominent nose (HP:0000448)1.72210610
113Enlarged penis (HP:0000040)1.71357458
114Bowing of the arm (HP:0006488)1.71254906
115Bowed forearm bones (HP:0003956)1.71254906
116Missing ribs (HP:0000921)1.70865547
117Broad finger (HP:0001500)1.70492359
118Broad phalanx (HP:0006009)1.70240846
119Periodontitis (HP:0000704)1.69908723
120Thick eyebrow (HP:0000574)1.69230055
121Ankle contracture (HP:0006466)1.69185020
122Short nail (HP:0001799)1.68035999
123Vertebral arch anomaly (HP:0008438)1.67955102
124Spondylolisthesis (HP:0003302)1.67631269
125Trismus (HP:0000211)1.66007876
126Vitreoretinal degeneration (HP:0000655)1.65395872
127Thoracolumbar scoliosis (HP:0002944)1.65212650
128Abnormality of oral frenula (HP:0000190)1.64769113
129Cafe-au-lait spot (HP:0000957)1.64342653
130Anal stenosis (HP:0002025)1.64337767
131Spinal muscular atrophy (HP:0007269)1.64260551
132Broad palm (HP:0001169)1.63989735
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.63982731
134Midface retrusion (HP:0011800)1.63904120
135Pointed chin (HP:0000307)1.63223837
136Fatigue (HP:0012378)1.63186454
137Gastrointestinal carcinoma (HP:0002672)1.62652947
138Malignant gastrointestinal tract tumors (HP:0006749)1.62652947
139Papilledema (HP:0001085)1.62304386
140Cervical subluxation (HP:0003308)1.61473045
141Mitral regurgitation (HP:0001653)1.61330223
142Dilatation of the ascending aorta (HP:0005111)1.61008198
143Medulloblastoma (HP:0002885)1.60818063
144Wide nose (HP:0000445)1.60674224
145Recurrent abscess formation (HP:0002722)1.59622225
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59518642
147Flat acetabular roof (HP:0003180)1.59130547
148Hypoplasia of the maxilla (HP:0000327)1.59033702
149Broad long bones (HP:0005622)1.58755870
150Bowel diverticulosis (HP:0005222)1.58597439
151Arachnodactyly (HP:0001166)1.58570802
152Insomnia (HP:0100785)1.58345349
153Abnormality of the carotid arteries (HP:0005344)1.58286569
154Skin tags (HP:0010609)1.57890421
155Heterotopia (HP:0002282)1.57526417
156Abnormal ossification of hand bones (HP:0005921)1.57444894
157Broad ribs (HP:0000885)1.56691599
158Relative macrocephaly (HP:0004482)1.56499762
159Abnormality of the intervertebral disk (HP:0005108)1.56499726
160Long toe (HP:0010511)1.56185758
161Nephroblastoma (Wilms tumor) (HP:0002667)1.55991656
162Osteomyelitis (HP:0002754)1.55897328
163Abnormality of the columella (HP:0009929)1.55725197
164Leiomyosarcoma (HP:0100243)1.54290712
165Uterine leiomyosarcoma (HP:0002891)1.54290712
166Deviation of the thumb (HP:0009603)1.53523079
167Recurrent bacterial skin infections (HP:0005406)1.53322324
168Abnormality of carpal bone ossification (HP:0006257)1.53201960
169Poikiloderma (HP:0001029)1.52871552
170Long clavicles (HP:0000890)1.52531000
171Exostoses (HP:0100777)1.52358059
172Inguinal hernia (HP:0000023)1.52283650
173Rhizomelia (HP:0008905)1.52019338
174Camptodactyly of toe (HP:0001836)1.51866016
175Embryonal renal neoplasm (HP:0011794)1.51231540
176Ectopia lentis (HP:0001083)1.51118819
177Partial duplication of the phalanx of hand (HP:0009999)1.50833921
178Limb-girdle muscle weakness (HP:0003325)1.50644415
179Turricephaly (HP:0000262)1.50149644
180Back pain (HP:0003418)1.49980939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.01514824
2MAP3K132.99556875
3PKN22.98303812
4CDK122.98219989
5EEF2K2.92064563
6CAMK1G2.66813730
7FLT32.46644725
8CAMK1D2.25181079
9TAOK32.12428910
10PTK62.11466054
11MET2.11084439
12SMG12.07915976
13ERBB42.02495523
14BRD42.00346149
15NEK11.96929462
16NTRK11.89862242
17LATS11.82374361
18TRIB31.80792335
19TSSK61.80323662
20SCYL21.79611080
21TAF11.79327179
22VRK21.75541279
23MAP3K101.73994259
24STK31.72699740
25PBK1.61650899
26ICK1.61394353
27PDGFRA1.59656943
28NEK21.54185575
29STK38L1.52813611
30ALK1.51307706
31CSF1R1.49411985
32MAP4K11.47714377
33KIT1.45227083
34RIPK11.41443189
35MYLK1.40503935
36CDK61.38203700
37JAK31.37899722
38CDK191.32578915
39TTN1.31822546
40RPS6KB21.27224004
41SRPK11.25584121
42STK101.24124506
43CDK41.23420763
44MAP3K61.23351205
45DMPK1.21392287
46TTK1.21359385
47MAP3K81.18743545
48TRPM71.17125975
49ATR1.16541815
50SIK11.15789350
51WNK11.14027213
52EPHA21.13828732
53PLK31.13120251
54BUB11.13063110
55SIK21.12811056
56MST1R1.12711970
57MELK1.12677148
58PAK41.11831232
59EIF2AK11.09197607
60CDK91.08807387
61TGFBR11.06674529
62AKT31.04854615
63CHEK11.03854992
64RPS6KA41.02162919
65LATS21.00201261
66MTOR0.99597012
67MAP3K140.98546393
68MKNK20.95267821
69MKNK10.94609127
70CHUK0.93857812
71FGFR10.93611936
72CHEK20.92853532
73PNCK0.90946994
74PDGFRB0.90540120
75TYK20.86307030
76DDR20.84309884
77MAP2K30.83620669
78NEK90.82765755
79RET0.81019340
80BMX0.80744033
81ARAF0.79565927
82FGFR40.79110129
83MOS0.78449044
84HIPK20.76745541
85BRSK20.75654358
86EPHB20.75439324
87PAK20.75131441
88HCK0.74593819
89ATM0.73876668
90FES0.73822085
91BTK0.72208135
92PIM10.71555650
93CDK70.71520466
94SGK30.70428458
95JAK10.69961636
96TGFBR20.68811610
97CDK20.68591269
98LRRK20.66050099
99AURKB0.64749155
100IKBKB0.64591187
101BRAF0.62778071
102PRKD20.62752195
103RAF10.60120656
104PRKG20.59143725
105ZAP700.57716685
106NME20.57228675
107EIF2AK30.56873985
108CDC42BPA0.56215414
109ERN10.55652306
110AKT20.55319222
111CLK10.54870577
112LIMK10.54362803
113CAMKK20.54212853
114CDK80.52448040
115PLK10.52199102
116PTK20.51718200
117TBK10.50686919
118EGFR0.50450091
119PASK0.49941111
120CSNK1A1L0.49730028
121MAP3K90.49300024
122MAPK140.49215876
123AURKA0.48912244
124ABL10.47785549
125NUAK10.47526805
126SYK0.47169968
127LCK0.46157081
128MAPK100.46142756
129LYN0.45996226
130GSK3A0.45866609
131CAMKK10.45816519
132STK40.45810491
133ILK0.45591905
134CDK10.44643555
135KSR20.44376077
136AKT10.44375695
137JAK20.43803365
138ROCK20.43183253
139CSK0.43178548
140EIF2AK20.43151488
141STK240.41097133
142MAPK10.41024669
143CSNK1E0.40730197
144RPS6KA20.40404464
145DYRK30.38944219
146STK380.38716362
147PIK3CG0.38710197

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.07813817
2Cell cycle_Homo sapiens_hsa041102.00274833
3Lysine degradation_Homo sapiens_hsa003101.99712079
4Chronic myeloid leukemia_Homo sapiens_hsa052201.98319153
5Selenocompound metabolism_Homo sapiens_hsa004501.84743630
6Hippo signaling pathway_Homo sapiens_hsa043901.81382736
7One carbon pool by folate_Homo sapiens_hsa006701.77513169
8Thyroid cancer_Homo sapiens_hsa052161.75752834
9Small cell lung cancer_Homo sapiens_hsa052221.70378432
10MicroRNAs in cancer_Homo sapiens_hsa052061.66415708
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.65359696
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63011141
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61320909
14Biosynthesis of amino acids_Homo sapiens_hsa012301.56406920
15Basal cell carcinoma_Homo sapiens_hsa052171.54424438
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54053594
17Pancreatic cancer_Homo sapiens_hsa052121.52319369
18Fanconi anemia pathway_Homo sapiens_hsa034601.50638323
19RNA transport_Homo sapiens_hsa030131.49982181
20DNA replication_Homo sapiens_hsa030301.47655651
21* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47421168
22Non-small cell lung cancer_Homo sapiens_hsa052231.42594945
23Osteoclast differentiation_Homo sapiens_hsa043801.33256413
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.31897792
25Ribosome_Homo sapiens_hsa030101.30955179
26Viral carcinogenesis_Homo sapiens_hsa052031.29635531
27Proteoglycans in cancer_Homo sapiens_hsa052051.28708807
28Acute myeloid leukemia_Homo sapiens_hsa052211.27790030
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26681103
30Hepatitis B_Homo sapiens_hsa051611.26538116
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25643200
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24411587
33mTOR signaling pathway_Homo sapiens_hsa041501.24324150
34mRNA surveillance pathway_Homo sapiens_hsa030151.24302373
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24009204
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22780505
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22720365
38* Herpes simplex infection_Homo sapiens_hsa051681.22087340
39Tight junction_Homo sapiens_hsa045301.22061986
40Melanoma_Homo sapiens_hsa052181.21769089
41Vitamin B6 metabolism_Homo sapiens_hsa007501.21623758
42Mismatch repair_Homo sapiens_hsa034301.19700929
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18314378
44HTLV-I infection_Homo sapiens_hsa051661.17217029
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16915801
46Wnt signaling pathway_Homo sapiens_hsa043101.16619604
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15913056
48Glioma_Homo sapiens_hsa052141.14266379
49Colorectal cancer_Homo sapiens_hsa052101.13920445
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.11571115
51Adherens junction_Homo sapiens_hsa045201.10812349
52Prostate cancer_Homo sapiens_hsa052151.06655795
53Non-homologous end-joining_Homo sapiens_hsa034501.06505625
54Focal adhesion_Homo sapiens_hsa045101.06252568
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06215814
56Hedgehog signaling pathway_Homo sapiens_hsa043401.05919222
57Shigellosis_Homo sapiens_hsa051311.04347751
58Leishmaniasis_Homo sapiens_hsa051401.04274086
59Dorso-ventral axis formation_Homo sapiens_hsa043201.03993143
60TNF signaling pathway_Homo sapiens_hsa046681.03798859
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02595730
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01520644
63Apoptosis_Homo sapiens_hsa042101.00080852
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98845623
65Toxoplasmosis_Homo sapiens_hsa051450.96949269
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96928563
67Dilated cardiomyopathy_Homo sapiens_hsa054140.96804098
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96126619
69Base excision repair_Homo sapiens_hsa034100.95860243
70Carbon metabolism_Homo sapiens_hsa012000.94530108
71Platelet activation_Homo sapiens_hsa046110.94439934
72Type II diabetes mellitus_Homo sapiens_hsa049300.93362448
73Prolactin signaling pathway_Homo sapiens_hsa049170.92359227
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92301011
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92079088
76RNA degradation_Homo sapiens_hsa030180.91711380
77Spliceosome_Homo sapiens_hsa030400.88674099
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87978073
79Renal cell carcinoma_Homo sapiens_hsa052110.87505078
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87353462
81* Measles_Homo sapiens_hsa051620.87217486
82Viral myocarditis_Homo sapiens_hsa054160.86511132
83Notch signaling pathway_Homo sapiens_hsa043300.86138089
84HIF-1 signaling pathway_Homo sapiens_hsa040660.85838625
85Basal transcription factors_Homo sapiens_hsa030220.85296883
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85112534
87* Epstein-Barr virus infection_Homo sapiens_hsa051690.84364563
88* Influenza A_Homo sapiens_hsa051640.84214180
89Insulin resistance_Homo sapiens_hsa049310.82159526
90Pyruvate metabolism_Homo sapiens_hsa006200.82031918
91TGF-beta signaling pathway_Homo sapiens_hsa043500.80021861
92Pyrimidine metabolism_Homo sapiens_hsa002400.79900666
93Endometrial cancer_Homo sapiens_hsa052130.79795557
94Choline metabolism in cancer_Homo sapiens_hsa052310.79390418
95Systemic lupus erythematosus_Homo sapiens_hsa053220.79176701
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.76802547
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76521615
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.76253036
99Protein digestion and absorption_Homo sapiens_hsa049740.75331614
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74516370
101Homologous recombination_Homo sapiens_hsa034400.74060813
102Inositol phosphate metabolism_Homo sapiens_hsa005620.73633269
103Pathways in cancer_Homo sapiens_hsa052000.73144396
104Malaria_Homo sapiens_hsa051440.72681650
105Chemokine signaling pathway_Homo sapiens_hsa040620.72403595
106p53 signaling pathway_Homo sapiens_hsa041150.72082051
107ECM-receptor interaction_Homo sapiens_hsa045120.71356431
108FoxO signaling pathway_Homo sapiens_hsa040680.70842329
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70441554
110Pentose phosphate pathway_Homo sapiens_hsa000300.70235451
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68788056
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.68005624
113T cell receptor signaling pathway_Homo sapiens_hsa046600.66027837
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65979501
115ErbB signaling pathway_Homo sapiens_hsa040120.65475887
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.65399406
117Steroid biosynthesis_Homo sapiens_hsa001000.65327523
118Amoebiasis_Homo sapiens_hsa051460.64777305
119Tuberculosis_Homo sapiens_hsa051520.64383325
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63998223
121Melanogenesis_Homo sapiens_hsa049160.63581114
122Bladder cancer_Homo sapiens_hsa052190.63370898
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63089979
124RNA polymerase_Homo sapiens_hsa030200.62309730
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62257029
126Nucleotide excision repair_Homo sapiens_hsa034200.61798685
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61724935
128Oocyte meiosis_Homo sapiens_hsa041140.61513667
129Estrogen signaling pathway_Homo sapiens_hsa049150.60197311
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59496110
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.58839310
132N-Glycan biosynthesis_Homo sapiens_hsa005100.58345417
133MAPK signaling pathway_Homo sapiens_hsa040100.58332604
134Legionellosis_Homo sapiens_hsa051340.58094899
135VEGF signaling pathway_Homo sapiens_hsa043700.57996116
136Axon guidance_Homo sapiens_hsa043600.57620562
137Insulin signaling pathway_Homo sapiens_hsa049100.56691795
138Hematopoietic cell lineage_Homo sapiens_hsa046400.55473159
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52809558
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50549834
141AMPK signaling pathway_Homo sapiens_hsa041520.50473996
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46130155
143Glucagon signaling pathway_Homo sapiens_hsa049220.44146339
144Rap1 signaling pathway_Homo sapiens_hsa040150.43928532
145Thyroid hormone synthesis_Homo sapiens_hsa049180.43663611
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41354280
147Glutathione metabolism_Homo sapiens_hsa004800.40939051
148Galactose metabolism_Homo sapiens_hsa000520.38630593

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