EIF2B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.38662923
2DNA deamination (GO:0045006)5.17743887
3maturation of SSU-rRNA (GO:0030490)5.01620113
4viral transcription (GO:0019083)4.95138511
5translational termination (GO:0006415)4.81226177
6formation of translation preinitiation complex (GO:0001731)4.74337711
7ribosomal small subunit biogenesis (GO:0042274)4.51424638
8proteasome assembly (GO:0043248)4.46424598
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44795400
10DNA strand elongation involved in DNA replication (GO:0006271)4.43962518
11translational elongation (GO:0006414)4.40507931
12cotranslational protein targeting to membrane (GO:0006613)4.35961529
13protein targeting to ER (GO:0045047)4.33319832
14* translational initiation (GO:0006413)4.26462151
15DNA strand elongation (GO:0022616)4.25728265
16ribosomal large subunit biogenesis (GO:0042273)4.20751893
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.11151449
18telomere maintenance via semi-conservative replication (GO:0032201)4.10743850
19protein localization to endoplasmic reticulum (GO:0070972)4.08044213
20nucleobase biosynthetic process (GO:0046112)4.03684370
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.03063659
22DNA replication initiation (GO:0006270)4.01532478
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95333215
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95333215
25ribonucleoprotein complex biogenesis (GO:0022613)3.94490211
26respiratory chain complex IV assembly (GO:0008535)3.93510782
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.88150651
28viral life cycle (GO:0019058)3.87621109
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.86224615
30purine nucleobase biosynthetic process (GO:0009113)3.85998459
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85133450
32termination of RNA polymerase III transcription (GO:0006386)3.84804903
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.84804903
34cellular protein complex disassembly (GO:0043624)3.84724102
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81020806
36protein neddylation (GO:0045116)3.79307873
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77042133
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.75314765
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75154543
40negative regulation of ligase activity (GO:0051352)3.75154543
41chaperone-mediated protein transport (GO:0072321)3.74882022
42ribosome biogenesis (GO:0042254)3.72228597
43protein targeting to mitochondrion (GO:0006626)3.70311336
44protein K6-linked ubiquitination (GO:0085020)3.67622349
45* translation (GO:0006412)3.66760923
46spliceosomal snRNP assembly (GO:0000387)3.64534359
47peptidyl-histidine modification (GO:0018202)3.62622688
48DNA replication checkpoint (GO:0000076)3.61892582
49protein maturation by protein folding (GO:0022417)3.61027218
50DNA unwinding involved in DNA replication (GO:0006268)3.60858149
51preassembly of GPI anchor in ER membrane (GO:0016254)3.58316215
52rRNA processing (GO:0006364)3.55140858
53telomere maintenance via recombination (GO:0000722)3.51484774
54ATP synthesis coupled proton transport (GO:0015986)3.50495193
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50495193
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49669718
57protein complex disassembly (GO:0043241)3.48980700
58IMP biosynthetic process (GO:0006188)3.46628330
59protein complex biogenesis (GO:0070271)3.46056330
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44438056
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44438056
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.43709383
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.43709383
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.43709383
65regulation of mitochondrial translation (GO:0070129)3.41802741
66rRNA metabolic process (GO:0016072)3.40465759
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39256877
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.39256877
69protein localization to mitochondrion (GO:0070585)3.39014614
70establishment of protein localization to mitochondrion (GO:0072655)3.38692726
71spliceosomal complex assembly (GO:0000245)3.38629147
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38315295
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36046413
74mitochondrial respiratory chain complex I assembly (GO:0032981)3.35604830
75NADH dehydrogenase complex assembly (GO:0010257)3.35604830
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35604830
77GTP biosynthetic process (GO:0006183)3.34664223
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.34042082
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31819820
80mitochondrial respiratory chain complex assembly (GO:0033108)3.30927225
81telomere maintenance via telomere lengthening (GO:0010833)3.30681160
82macromolecular complex disassembly (GO:0032984)3.29694670
83maturation of 5.8S rRNA (GO:0000460)3.28789916
84ribosome assembly (GO:0042255)3.26571596
85pseudouridine synthesis (GO:0001522)3.26249853
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26240983
87positive regulation of ligase activity (GO:0051351)3.25049185
88platelet dense granule organization (GO:0060155)3.23094600
89cellular component biogenesis (GO:0044085)3.21866035
90mitotic metaphase plate congression (GO:0007080)3.21709373
91regulation of cellular amino acid metabolic process (GO:0006521)3.19519322
92rRNA methylation (GO:0031167)3.19497890
93cytochrome complex assembly (GO:0017004)3.15343744
94mannosylation (GO:0097502)3.14918160
95transcription-coupled nucleotide-excision repair (GO:0006283)3.14520521
96* L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14044334
97C-terminal protein lipidation (GO:0006501)3.13619468
987-methylguanosine mRNA capping (GO:0006370)3.12715582
99cullin deneddylation (GO:0010388)3.12558190
100protein deneddylation (GO:0000338)3.11859718
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11744576
102nucleotide-excision repair, DNA gap filling (GO:0006297)3.11662300
103mitotic recombination (GO:0006312)3.11544931
104rRNA modification (GO:0000154)3.10536096
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.10078617
106respiratory electron transport chain (GO:0022904)3.09888347
107somatic hypermutation of immunoglobulin genes (GO:0016446)3.07452787
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07452787
109electron transport chain (GO:0022900)3.06916069
110guanosine-containing compound biosynthetic process (GO:1901070)3.05935792
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.05846178
112G1/S transition of mitotic cell cycle (GO:0000082)3.05743115
113cell cycle G1/S phase transition (GO:0044843)3.05743115
114DNA damage response, detection of DNA damage (GO:0042769)3.04675785
115positive regulation of mitochondrial fission (GO:0090141)3.04538040
116folic acid-containing compound biosynthetic process (GO:0009396)3.04503505
117RNA capping (GO:0036260)3.04162631
1187-methylguanosine RNA capping (GO:0009452)3.04162631
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04087710
120viral mRNA export from host cell nucleus (GO:0046784)2.99952244
121water-soluble vitamin biosynthetic process (GO:0042364)2.99031504
122IMP metabolic process (GO:0046040)2.98014908
123regulation of ligase activity (GO:0051340)2.97933449
124tRNA metabolic process (GO:0006399)2.96820918
125UTP biosynthetic process (GO:0006228)2.96317575
126CTP metabolic process (GO:0046036)2.96207846
127CTP biosynthetic process (GO:0006241)2.96207846
128tRNA processing (GO:0008033)2.95702215
129mRNA catabolic process (GO:0006402)2.94354393
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93701397
131DNA double-strand break processing (GO:0000729)2.90685235
132mitotic nuclear envelope disassembly (GO:0007077)2.90347907
133positive regulation of cell cycle arrest (GO:0071158)2.90204789
134regulation of cellular amine metabolic process (GO:0033238)2.89002083
135UTP metabolic process (GO:0046051)2.88325658
136DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.88102252
137RNA catabolic process (GO:0006401)2.86789151
138DNA catabolic process, exonucleolytic (GO:0000738)2.86679197
139C-terminal protein amino acid modification (GO:0018410)2.85754744
140dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.85213149
141protein targeting to membrane (GO:0006612)2.83887287
142protein K11-linked ubiquitination (GO:0070979)2.83677093
143establishment of integrated proviral latency (GO:0075713)2.82315873
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82034284
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.80192236
146de novo protein folding (GO:0006458)2.79825728
147pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.79617276
148ncRNA processing (GO:0034470)2.78475162
149transcription from RNA polymerase I promoter (GO:0006360)2.77776828
150protein localization to kinetochore (GO:0034501)2.76581415
151CENP-A containing nucleosome assembly (GO:0034080)2.75934405
152ubiquinone biosynthetic process (GO:0006744)2.74293452
153de novo posttranslational protein folding (GO:0051084)2.73252507
154amino acid activation (GO:0043038)2.72933670
155tRNA aminoacylation (GO:0043039)2.72933670
156DNA replication-dependent nucleosome organization (GO:0034723)2.72559076
157DNA replication-dependent nucleosome assembly (GO:0006335)2.72559076
158metaphase plate congression (GO:0051310)2.71782465
159tRNA aminoacylation for protein translation (GO:0006418)2.71752973
160RNA splicing, via transesterification reactions (GO:0000375)2.71623566
161pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.70649510
162metallo-sulfur cluster assembly (GO:0031163)2.69889410
163iron-sulfur cluster assembly (GO:0016226)2.69889410
164positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69333646
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69038684
166establishment of viral latency (GO:0019043)2.68970491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59642037
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.08846857
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08511805
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38731957
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33379145
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.26414430
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.25757491
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.21641211
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99441481
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97768125
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89961825
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86517127
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75384075
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68723230
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51218122
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.50655093
17XRN2_22483619_ChIP-Seq_HELA_Human2.42658403
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40828572
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40459768
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33794646
21VDR_23849224_ChIP-Seq_CD4+_Human2.31051463
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28428592
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23440435
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18138897
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17525242
26DCP1A_22483619_ChIP-Seq_HELA_Human2.12292313
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07060323
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03152629
29* GABP_19822575_ChIP-Seq_HepG2_Human2.01967828
30FOXP3_21729870_ChIP-Seq_TREG_Human1.97563983
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95015174
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85904752
33TTF2_22483619_ChIP-Seq_HELA_Human1.84684843
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.81190413
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81147004
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.80541812
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76833390
38CIITA_25753668_ChIP-Seq_RAJI_Human1.75718945
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72618886
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66132145
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65694716
42ZNF274_21170338_ChIP-Seq_K562_Hela1.65451303
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64761119
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64180191
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62694366
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62585208
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61774100
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60587059
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59325428
50MYC_22102868_ChIP-Seq_BL_Human1.59309647
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55734376
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55146260
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52667071
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49585580
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47902810
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.47125895
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45399468
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42263029
59KDM5A_27292631_Chip-Seq_BREAST_Human1.39988161
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39967683
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37156046
62* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36373210
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36028674
64* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31963217
65IRF1_19129219_ChIP-ChIP_H3396_Human1.31145893
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.28388482
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27408133
68VDR_21846776_ChIP-Seq_THP-1_Human1.27172254
69AR_21909140_ChIP-Seq_LNCAP_Human1.27138681
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21998959
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21149901
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20449033
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.19159377
74* TFEB_21752829_ChIP-Seq_HELA_Human1.18469882
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18464394
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17345254
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15380990
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13228173
79* ELK1_22589737_ChIP-Seq_MCF10A_Human1.12747018
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09964377
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08179526
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07151471
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06795969
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06483847
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05952596
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05866294
87SPI1_23547873_ChIP-Seq_NB4_Human1.05377375
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05299368
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03474342
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02023675
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00429002
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99300663
93VDR_22108803_ChIP-Seq_LS180_Human0.99057889
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.97452725
95TP53_22573176_ChIP-Seq_HFKS_Human0.97089550
96HTT_18923047_ChIP-ChIP_STHdh_Human0.96056907
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95854069
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93941374
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92167088
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92101066
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91909320
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91126328
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90888014
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90015317
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.89838507
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89132150
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88916605
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88470477
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88435026
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87927595
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87898256
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.87823340
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.86054439
114ELF5_23300383_ChIP-Seq_T47D_Human0.85346164
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85270362
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83838726
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83830139
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83639205
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83158584
120MYC_18940864_ChIP-ChIP_HL60_Human0.82410512
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.82134385
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81505132
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79822067
124* NCOR_22424771_ChIP-Seq_293T_Human0.75981152
125AR_20517297_ChIP-Seq_VCAP_Human0.74162526
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73682794
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72891064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08369171
2MP0004957_abnormal_blastocyst_morpholog4.07704641
3MP0003111_abnormal_nucleus_morphology3.68721572
4MP0003077_abnormal_cell_cycle3.67870974
5MP0010094_abnormal_chromosome_stability3.62683380
6MP0003950_abnormal_plasma_membrane3.24716026
7MP0008057_abnormal_DNA_replication3.11899620
8MP0002102_abnormal_ear_morphology3.08515467
9MP0008932_abnormal_embryonic_tissue2.81899521
10MP0008007_abnormal_cellular_replicative2.80387194
11MP0008058_abnormal_DNA_repair2.68868626
12MP0002837_dystrophic_cardiac_calcinosis2.53158719
13MP0002396_abnormal_hematopoietic_system2.41292717
14MP0009697_abnormal_copulation2.17144391
15MP0001529_abnormal_vocalization2.10580475
16MP0001730_embryonic_growth_arrest2.10535682
17MP0009333_abnormal_splenocyte_physiolog2.02956246
18MP0008875_abnormal_xenobiotic_pharmacok1.99582302
19MP0000490_abnormal_crypts_of1.96961803
20MP0000350_abnormal_cell_proliferation1.96668382
21MP0000372_irregular_coat_pigmentation1.94110838
22MP0006054_spinal_hemorrhage1.89554359
23MP0010352_gastrointestinal_tract_polyps1.86533365
24MP0003806_abnormal_nucleotide_metabolis1.85051620
25MP0002736_abnormal_nociception_after1.76520010
26MP0003786_premature_aging1.70866543
27MP0003123_paternal_imprinting1.63744269
28MP0003763_abnormal_thymus_physiology1.61094617
29MP0010030_abnormal_orbit_morphology1.56562850
30MP0003136_yellow_coat_color1.53576133
31MP0006072_abnormal_retinal_apoptosis1.53548338
32MP0000313_abnormal_cell_death1.52839761
33MP0001905_abnormal_dopamine_level1.52189627
34MP0001697_abnormal_embryo_size1.51706846
35MP0002080_prenatal_lethality1.49798299
36MP0005397_hematopoietic_system_phenotyp1.49506209
37MP0001545_abnormal_hematopoietic_system1.49506209
38MP0001661_extended_life_span1.49096680
39MP0005410_abnormal_fertilization1.49090329
40MP0002876_abnormal_thyroid_physiology1.48981481
41MP0005646_abnormal_pituitary_gland1.48957966
42MP0002132_abnormal_respiratory_system1.47033505
43MP0003186_abnormal_redox_activity1.46032276
44MP0008789_abnormal_olfactory_epithelium1.44073206
45MP0004808_abnormal_hematopoietic_stem1.42788383
46MP0008872_abnormal_physiological_respon1.41589101
47MP0000358_abnormal_cell_content/1.40079747
48MP0005451_abnormal_body_composition1.39410094
49MP0005389_reproductive_system_phenotype1.39213345
50MP0000750_abnormal_muscle_regeneration1.38205231
51MP0002019_abnormal_tumor_incidence1.37625040
52MP0005084_abnormal_gallbladder_morpholo1.37231796
53MP0002163_abnormal_gland_morphology1.32529537
54MP0001764_abnormal_homeostasis1.30999044
55MP0000703_abnormal_thymus_morphology1.30872949
56MP0001672_abnormal_embryogenesis/_devel1.30865090
57MP0005380_embryogenesis_phenotype1.30865090
58MP0002653_abnormal_ependyma_morphology1.30841789
59MP0002398_abnormal_bone_marrow1.29374693
60MP0003718_maternal_effect1.27947507
61MP0002722_abnormal_immune_system1.27523810
62MP0002234_abnormal_pharynx_morphology1.27344014
63MP0000689_abnormal_spleen_morphology1.25994620
64MP0003984_embryonic_growth_retardation1.25684824
65MP0006036_abnormal_mitochondrial_physio1.22875682
66MP0004147_increased_porphyrin_level1.22605717
67MP0002085_abnormal_embryonic_tissue1.22003603
68MP0003656_abnormal_erythrocyte_physiolo1.20197501
69MP0002088_abnormal_embryonic_growth/wei1.20112991
70MP0010307_abnormal_tumor_latency1.18152150
71MP0003011_delayed_dark_adaptation1.17550266
72MP0000858_altered_metastatic_potential1.16513971
73MP0005551_abnormal_eye_electrophysiolog1.15899517
74MP0001727_abnormal_embryo_implantation1.12534129
75MP0003567_abnormal_fetal_cardiomyocyte1.12271498
76MP0003221_abnormal_cardiomyocyte_apopto1.11377705
77MP0002429_abnormal_blood_cell1.10990502
78MP0000685_abnormal_immune_system1.10771127
79MP0001968_abnormal_touch/_nociception1.10505886
80MP0004215_abnormal_myocardial_fiber1.10046352
81MP0004133_heterotaxia1.09576529
82MP0005023_abnormal_wound_healing1.06390495
83MP0005330_cardiomyopathy1.05732771
84MP0001929_abnormal_gametogenesis1.05002472
85MP0010368_abnormal_lymphatic_system1.04330994
86MP0005253_abnormal_eye_physiology1.01623492
87MP0002177_abnormal_outer_ear0.99227661
88MP0002084_abnormal_developmental_patter0.98265235
89MP0001986_abnormal_taste_sensitivity0.97973806
90MP0002086_abnormal_extraembryonic_tissu0.97133090
91MP0005501_abnormal_skin_physiology0.97080266
92MP0000716_abnormal_immune_system0.96727564
93MP0001293_anophthalmia0.96592922
94MP0005075_abnormal_melanosome_morpholog0.96338595
95MP0000537_abnormal_urethra_morphology0.95077102
96MP0005083_abnormal_biliary_tract0.92876274
97MP0009046_muscle_twitch0.92392406
98MP0004233_abnormal_muscle_weight0.91686346
99MP0009780_abnormal_chondrocyte_physiolo0.90590642
100MP0005671_abnormal_response_to0.89613088
101MP0002405_respiratory_system_inflammati0.89297278
102MP0008260_abnormal_autophagy0.87893698
103MP0000653_abnormal_sex_gland0.87820106
104MP0005332_abnormal_amino_acid0.87146900
105MP0006276_abnormal_autonomic_nervous0.86629740
106MP0003137_abnormal_impulse_conducting0.86567955
107MP0003942_abnormal_urinary_system0.86530625
108MP0004197_abnormal_fetal_growth/weight/0.86302200
109MP0005384_cellular_phenotype0.85580052
110MP0008877_abnormal_DNA_methylation0.84909921
111MP0000465_gastrointestinal_hemorrhage0.83605080
112MP0001919_abnormal_reproductive_system0.82947799
113MP0000647_abnormal_sebaceous_gland0.82324667
114MP0003315_abnormal_perineum_morphology0.82210631
115MP0002420_abnormal_adaptive_immunity0.81868449
116MP0004145_abnormal_muscle_electrophysio0.81647319
117MP0005187_abnormal_penis_morphology0.81294808
118MP0002090_abnormal_vision0.81193913
119MP0001819_abnormal_immune_cell0.80581175
120MP0005408_hypopigmentation0.79924610
121MP0000013_abnormal_adipose_tissue0.79167779
122MP0008995_early_reproductive_senescence0.78982342
123MP0001853_heart_inflammation0.78674620
124MP0005621_abnormal_cell_physiology0.78464036
125MP0002909_abnormal_adrenal_gland0.78079046
126MP0000427_abnormal_hair_cycle0.77918682
127MP0002751_abnormal_autonomic_nervous0.77750968
128MP0001800_abnormal_humoral_immune0.77283943
129MP0000049_abnormal_middle_ear0.77168582
130MP0003755_abnormal_palate_morphology0.76441387
131MP0003698_abnormal_male_reproductive0.76366626
132MP0009785_altered_susceptibility_to0.76352190
133MP0001756_abnormal_urination0.76342845
134MP0001835_abnormal_antigen_presentation0.75781147
135MP0003866_abnormal_defecation0.75569904
136MP0006292_abnormal_olfactory_placode0.75305903
137MP0002723_abnormal_immune_serum0.75055217
138MP0005379_endocrine/exocrine_gland_phen0.74486560
139MP0002452_abnormal_antigen_presenting0.74448931
140MP0003937_abnormal_limbs/digits/tail_de0.74447425
141MP0003195_calcinosis0.73727050
142MP0000749_muscle_degeneration0.72808514
143MP0001542_abnormal_bone_strength0.71865502
144MP0005499_abnormal_olfactory_system0.69734341
145MP0005394_taste/olfaction_phenotype0.69734341
146MP0005360_urolithiasis0.69434463
147MP0000631_abnormal_neuroendocrine_gland0.68372142
148MP0005220_abnormal_exocrine_pancreas0.67556974
149MP0001145_abnormal_male_reproductive0.67107120
150MP0003436_decreased_susceptibility_to0.67085724
151MP0006035_abnormal_mitochondrial_morpho0.66535279
152MP0003566_abnormal_cell_adhesion0.66038371
153MP0010155_abnormal_intestine_physiology0.65586291
154MP0003119_abnormal_digestive_system0.65154485
155MP0003121_genomic_imprinting0.65100500
156MP0002210_abnormal_sex_determination0.65065155
157MP0009379_abnormal_foot_pigmentation0.64843330
158MP0000733_abnormal_muscle_development0.64251173
159MP0002269_muscular_atrophy0.64217040
160MP0002160_abnormal_reproductive_system0.63825874
161MP0005058_abnormal_lysosome_morphology0.63064339
162MP0000477_abnormal_intestine_morphology0.61474538
163MP0005000_abnormal_immune_tolerance0.61419739
164MP0005025_abnormal_response_to0.60450689
165MP0002938_white_spotting0.58952128
166MP0002095_abnormal_skin_pigmentation0.58453203
167MP0002111_abnormal_tail_morphology0.57795501

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.81362402
2Abnormal number of erythroid precursors (HP:0012131)4.59646062
3Reticulocytopenia (HP:0001896)4.45808141
4Acute encephalopathy (HP:0006846)4.07637801
5Birth length less than 3rd percentile (HP:0003561)3.98248783
6Aplastic anemia (HP:0001915)3.84304250
7* Cerebral hypomyelination (HP:0006808)3.67546634
8Carpal bone hypoplasia (HP:0001498)3.59727576
9Rough bone trabeculation (HP:0100670)3.46635665
10Oral leukoplakia (HP:0002745)3.46495997
11Progressive macrocephaly (HP:0004481)3.45161797
12Macrocytic anemia (HP:0001972)3.44850549
13Breast hypoplasia (HP:0003187)3.37013995
14Abnormality of the anterior horn cell (HP:0006802)3.34969255
15Degeneration of anterior horn cells (HP:0002398)3.34969255
16Pallor (HP:0000980)3.18403469
17Trismus (HP:0000211)3.06181836
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05268368
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97234319
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97234319
21Multiple enchondromatosis (HP:0005701)2.94156043
22Cerebral edema (HP:0002181)2.90971714
23Patellar aplasia (HP:0006443)2.86987559
24Aplasia/hypoplasia of the uterus (HP:0008684)2.84316780
25Generalized aminoaciduria (HP:0002909)2.82317170
26Selective tooth agenesis (HP:0001592)2.80870254
27Hepatocellular necrosis (HP:0001404)2.80399732
2811 pairs of ribs (HP:0000878)2.77440787
29Microretrognathia (HP:0000308)2.77409590
30Type I transferrin isoform profile (HP:0003642)2.76117989
31Abnormality of alanine metabolism (HP:0010916)2.74189385
32Hyperalaninemia (HP:0003348)2.74189385
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74189385
34Aplasia/Hypoplasia of the patella (HP:0006498)2.71074642
35Large for gestational age (HP:0001520)2.69531518
363-Methylglutaconic aciduria (HP:0003535)2.67967899
37Adrenal hypoplasia (HP:0000835)2.63292854
38Renal Fanconi syndrome (HP:0001994)2.60172902
39Increased serum lactate (HP:0002151)2.58081741
40Hepatic necrosis (HP:0002605)2.57807101
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56604315
42Abnormal protein N-linked glycosylation (HP:0012347)2.56604315
43Abnormal protein glycosylation (HP:0012346)2.56604315
44Abnormal glycosylation (HP:0012345)2.56604315
45Ependymoma (HP:0002888)2.56382216
46Premature graying of hair (HP:0002216)2.56036276
47Mitochondrial inheritance (HP:0001427)2.55535591
48Poor head control (HP:0002421)2.54769781
49Pancreatic cysts (HP:0001737)2.52019990
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51927634
51Reduced antithrombin III activity (HP:0001976)2.51186282
52Progressive microcephaly (HP:0000253)2.50218586
53Thrombocytosis (HP:0001894)2.47512910
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45856366
55Abnormality of the umbilical cord (HP:0010881)2.41734662
56Exertional dyspnea (HP:0002875)2.41556731
57Abnormality of glycolysis (HP:0004366)2.40666030
58Increased serum pyruvate (HP:0003542)2.40666030
59Abnormal trabecular bone morphology (HP:0100671)2.40098319
60Muscle fiber atrophy (HP:0100295)2.39432212
61Glossoptosis (HP:0000162)2.39174731
62Optic disc pallor (HP:0000543)2.32321420
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31973340
64Increased CSF lactate (HP:0002490)2.30883359
65Abnormality of midbrain morphology (HP:0002418)2.29954339
66Molar tooth sign on MRI (HP:0002419)2.29954339
67Amniotic constriction ring (HP:0009775)2.28011982
68Abnormality of placental membranes (HP:0011409)2.28011982
69Increased hepatocellular lipid droplets (HP:0006565)2.26255936
70Pancreatic fibrosis (HP:0100732)2.25485579
71* Lethargy (HP:0001254)2.24669573
72Type 2 muscle fiber atrophy (HP:0003554)2.24415843
73Absent thumb (HP:0009777)2.23649367
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22372826
75Colon cancer (HP:0003003)2.21500494
76Calcaneovalgus deformity (HP:0001848)2.20746284
77Renal cortical cysts (HP:0000803)2.18312096
78Pancytopenia (HP:0001876)2.18024494
79Hypoplasia of the pons (HP:0012110)2.16668033
80Bone marrow hypocellularity (HP:0005528)2.16126550
81Medial flaring of the eyebrow (HP:0010747)2.16037957
82Hypoplasia of the uterus (HP:0000013)2.13523508
83Abnormality of the pons (HP:0007361)2.10720843
84Exercise intolerance (HP:0003546)2.09201116
85Irregular epiphyses (HP:0010582)2.09128873
86IgM deficiency (HP:0002850)2.07986389
87Neoplasm of the pancreas (HP:0002894)2.07520915
88Abnormal mitochondria in muscle tissue (HP:0008316)2.07439763
89Progressive muscle weakness (HP:0003323)2.06936070
90Increased intramyocellular lipid droplets (HP:0012240)2.06266695
91Ureteral duplication (HP:0000073)2.06115084
92Duplicated collecting system (HP:0000081)2.05910212
93Acute necrotizing encephalopathy (HP:0006965)2.04009421
94Hyperglycinemia (HP:0002154)2.03057989
95Petechiae (HP:0000967)2.02616144
96Testicular atrophy (HP:0000029)2.02097566
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.01885945
98Meckel diverticulum (HP:0002245)2.00414089
99Abnormality of the calcaneus (HP:0008364)1.99852001
100Delayed CNS myelination (HP:0002188)1.99536708
101* Secondary amenorrhea (HP:0000869)1.99254405
102Severe muscular hypotonia (HP:0006829)1.97884911
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97825137
104Absent epiphyses (HP:0010577)1.97825137
105Nephrogenic diabetes insipidus (HP:0009806)1.96970489
106Abnormality of the ileum (HP:0001549)1.96821187
107Abnormality of serum amino acid levels (HP:0003112)1.96644839
108Lipid accumulation in hepatocytes (HP:0006561)1.96497122
109Abnormality of the renal collecting system (HP:0004742)1.96097660
110Cellular immunodeficiency (HP:0005374)1.94849915
111Type II lissencephaly (HP:0007260)1.94492859
112Abnormality of the preputium (HP:0100587)1.94410471
113* Postnatal microcephaly (HP:0005484)1.93985452
114Congenital primary aphakia (HP:0007707)1.92333975
115True hermaphroditism (HP:0010459)1.91292720
116Sclerocornea (HP:0000647)1.91129834
117Abnormal number of incisors (HP:0011064)1.90797823
118Microvesicular hepatic steatosis (HP:0001414)1.90737030
119Hyperglycinuria (HP:0003108)1.90047184
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.89070898
121Poor suck (HP:0002033)1.89009392
122* CNS hypomyelination (HP:0003429)1.88437751
123Retinal dysplasia (HP:0007973)1.88367394
124Deformed tarsal bones (HP:0008119)1.88095575
125* CNS demyelination (HP:0007305)1.85623317
126Slender long bone (HP:0003100)1.84821678
127Hypoglycemic coma (HP:0001325)1.84399626
128Sparse eyelashes (HP:0000653)1.82877037
129Cleft eyelid (HP:0000625)1.82770972
130Abnormality of methionine metabolism (HP:0010901)1.82320936
131Gait imbalance (HP:0002141)1.81994806
132* Emotional lability (HP:0000712)1.81565121
133Horseshoe kidney (HP:0000085)1.81457140
134Lactic acidosis (HP:0003128)1.80921777
135Myelodysplasia (HP:0002863)1.80849781
136Lymphoma (HP:0002665)1.80638422
137Astrocytoma (HP:0009592)1.80051370
138Abnormality of the astrocytes (HP:0100707)1.80051370
139Tongue fasciculations (HP:0001308)1.78684370
140Opisthotonus (HP:0002179)1.77631228
141Agnosia (HP:0010524)1.77344544
142Myopathic facies (HP:0002058)1.76495350
143Abnormality of reticulocytes (HP:0004312)1.75686591
144* Premature ovarian failure (HP:0008209)1.75604932
145Missing ribs (HP:0000921)1.75064633
146Respiratory failure (HP:0002878)1.74558944
147Increased muscle lipid content (HP:0009058)1.72805972
148Cholecystitis (HP:0001082)1.72628866
149Abnormal gallbladder physiology (HP:0012438)1.72628866
150Entropion (HP:0000621)1.72092252
151Atresia of the external auditory canal (HP:0000413)1.71141743
152Delayed gross motor development (HP:0002194)1.70579817
153Neoplasm of the adrenal gland (HP:0100631)1.69796952
154Occipital encephalocele (HP:0002085)1.69575782
155X-linked dominant inheritance (HP:0001423)1.64300767
156Upper limb muscle weakness (HP:0003484)1.64109861
157Glycosuria (HP:0003076)1.62960299
158Abnormality of urine glucose concentration (HP:0011016)1.62960299
159Methylmalonic aciduria (HP:0012120)1.62774699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.40149505
2VRK23.50684715
3WEE13.45919323
4EIF2AK13.42593921
5NME23.25473127
6STK163.07111116
7TRIM282.84808757
8TESK22.69652813
9BMPR1B2.61148387
10TSSK62.61122950
11PIM22.39873910
12VRK12.16922892
13MAP4K22.15749733
14TLK12.10587371
15PINK11.99707061
16CDC71.98529540
17EIF2AK31.81072201
18NUAK11.79807417
19MUSK1.79755875
20PLK41.77064220
21BRSK21.72019716
22TIE11.67323018
23RPS6KB21.64546798
24DYRK31.62356389
25CSNK1G31.61132363
26PASK1.60197239
27NEK21.58592831
28BCKDK1.56418075
29SRPK11.54716416
30MAP4K11.54373778
31NME11.53154082
32ADRBK21.52962250
33CSNK1G11.52583186
34MAP3K121.47336326
35PLK11.45744133
36MAP3K111.44474957
37ACVR1B1.44223207
38KDR1.42846085
39CDK71.41491190
40CSNK1A1L1.40090545
41TGFBR11.39114737
42RPS6KA41.37807592
43NEK11.35233235
44TTK1.34593132
45AURKB1.31347563
46PAK41.28808173
47TESK11.27608516
48STK101.24325161
49AURKA1.23489200
50MAP2K71.23280020
51PDK21.21647719
52LRRK21.19854007
53MAP3K101.19284153
54EEF2K1.18218694
55EPHA21.17642838
56WNK31.17145862
57MAP3K81.15004436
58BRSK11.14965861
59ILK1.10269630
60ATR1.08724829
61CSNK1G21.07491398
62FRK1.07348030
63CLK11.05398329
64MAPKAPK31.04555534
65ZAK1.03274188
66LIMK11.02744751
67ZAP701.02360192
68PHKG10.99439897
69PHKG20.99439897
70FLT30.94341846
71GRK10.92692320
72BCR0.92387278
73PAK10.92342626
74ERN10.92024002
75EIF2AK20.90720468
76DAPK10.90606664
77PLK30.89406441
78MYLK0.87476353
79CDK80.85024511
80MKNK10.84552968
81CDK190.83381150
82IRAK30.80771728
83MAP2K20.79389238
84BTK0.79001130
85CDK40.77369239
86PIM10.74065007
87MAP2K30.72508281
88BLK0.71967889
89BRAF0.71576326
90STK40.70461811
91CCNB10.68847492
92MAP3K40.67061547
93TRIB30.66481685
94ABL20.65854369
95ERBB30.64857777
96CHEK20.63619931
97CSNK2A10.63271478
98CHEK10.63036359
99DYRK20.61454529
100CSNK2A20.61141250
101TBK10.59834628
102PRKCI0.59476347
103OBSCN0.58435092
104PTK2B0.55886002
105RPS6KA50.52652366
106DAPK30.51330787
107IKBKB0.51180803
108TEC0.51107923
109CDK20.49657828
110PLK20.49556001
111MST40.48414274
112ADRBK10.47204451
113MAPKAPK50.47065203
114AKT20.43995141
115CAMK2D0.41607608
116SCYL20.41172178
117NLK0.40145104
118PRKCE0.39953712
119MINK10.39805063
120TAF10.39789642
121MAP3K50.39474502
122ERBB40.37989293
123PBK0.37400344
124MET0.37249385
125ARAF0.36460315
126CSNK1A10.35831051
127GRK50.34840541
128ATM0.34833519
129PKN20.32635602
130MST1R0.32361801
131KIT0.32213255
132IRAK40.31786202
133MAPKAPK20.31442437
134RPS6KA60.31246089
135TAOK20.28881326
136FER0.28655229
137CSNK1D0.28460758
138CDK10.27847200
139PAK20.27407978
140CAMKK20.26790308
141MAP3K30.26681673
142GRK60.25936868
143LYN0.25614035
144MELK0.25245866
145RPS6KC10.24878640
146RPS6KL10.24878640

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39381144
2DNA replication_Homo sapiens_hsa030304.33561542
3Proteasome_Homo sapiens_hsa030504.17413928
4RNA polymerase_Homo sapiens_hsa030203.76677746
5Mismatch repair_Homo sapiens_hsa034303.42914654
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06131643
7Spliceosome_Homo sapiens_hsa030402.98314306
8Base excision repair_Homo sapiens_hsa034102.89594658
9Pyrimidine metabolism_Homo sapiens_hsa002402.60105693
10* RNA transport_Homo sapiens_hsa030132.52637042
11Nucleotide excision repair_Homo sapiens_hsa034202.45270079
12Homologous recombination_Homo sapiens_hsa034402.41133403
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28139254
14Protein export_Homo sapiens_hsa030602.24152335
15Cell cycle_Homo sapiens_hsa041102.07498420
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93393241
17Fatty acid elongation_Homo sapiens_hsa000621.89798662
18One carbon pool by folate_Homo sapiens_hsa006701.84356493
19Sulfur metabolism_Homo sapiens_hsa009201.83719509
20Folate biosynthesis_Homo sapiens_hsa007901.59755463
21Sulfur relay system_Homo sapiens_hsa041221.54736031
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54061131
23Non-homologous end-joining_Homo sapiens_hsa034501.53874453
24Basal transcription factors_Homo sapiens_hsa030221.53123550
25Parkinsons disease_Homo sapiens_hsa050121.47973035
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47788951
27p53 signaling pathway_Homo sapiens_hsa041151.43132551
28Fanconi anemia pathway_Homo sapiens_hsa034601.42504438
29Oxidative phosphorylation_Homo sapiens_hsa001901.39907622
30RNA degradation_Homo sapiens_hsa030181.38675508
31Purine metabolism_Homo sapiens_hsa002301.37232382
32Pyruvate metabolism_Homo sapiens_hsa006201.34010202
33Epstein-Barr virus infection_Homo sapiens_hsa051691.32243196
34Propanoate metabolism_Homo sapiens_hsa006401.31909241
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29838809
36Huntingtons disease_Homo sapiens_hsa050161.21273854
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20616946
38Vitamin B6 metabolism_Homo sapiens_hsa007501.06297739
39Pentose phosphate pathway_Homo sapiens_hsa000301.05417093
40Butanoate metabolism_Homo sapiens_hsa006501.05379507
41mRNA surveillance pathway_Homo sapiens_hsa030151.03567568
42Steroid biosynthesis_Homo sapiens_hsa001001.02347051
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95946367
44Peroxisome_Homo sapiens_hsa041460.91953033
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91054551
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89662096
47Antigen processing and presentation_Homo sapiens_hsa046120.87060962
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86682165
49Biosynthesis of amino acids_Homo sapiens_hsa012300.86318553
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85844428
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83127629
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.82083512
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.81581156
54Phototransduction_Homo sapiens_hsa047440.80327287
55Glutathione metabolism_Homo sapiens_hsa004800.79425524
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77780250
57Primary immunodeficiency_Homo sapiens_hsa053400.77532176
58Collecting duct acid secretion_Homo sapiens_hsa049660.74968815
59Viral carcinogenesis_Homo sapiens_hsa052030.72287215
60Alzheimers disease_Homo sapiens_hsa050100.71437277
61beta-Alanine metabolism_Homo sapiens_hsa004100.68544804
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.68325281
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68296156
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.67738777
65Herpes simplex infection_Homo sapiens_hsa051680.67356302
66Legionellosis_Homo sapiens_hsa051340.64835493
67Shigellosis_Homo sapiens_hsa051310.62641700
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62545600
69N-Glycan biosynthesis_Homo sapiens_hsa005100.62335669
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62187211
71Fatty acid metabolism_Homo sapiens_hsa012120.61957419
72Fructose and mannose metabolism_Homo sapiens_hsa000510.59093265
73Tryptophan metabolism_Homo sapiens_hsa003800.58383528
74Galactose metabolism_Homo sapiens_hsa000520.57628909
75Carbon metabolism_Homo sapiens_hsa012000.57396439
76Systemic lupus erythematosus_Homo sapiens_hsa053220.57260459
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.57047990
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53993432
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51457847
80Nitrogen metabolism_Homo sapiens_hsa009100.51163867
81HTLV-I infection_Homo sapiens_hsa051660.51002160
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.50669220
83Apoptosis_Homo sapiens_hsa042100.50295367
84Chemical carcinogenesis_Homo sapiens_hsa052040.49935143
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46687469
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46571458
87Selenocompound metabolism_Homo sapiens_hsa004500.46498590
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44481155
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43613318
90Thyroid cancer_Homo sapiens_hsa052160.43147822
91Regulation of autophagy_Homo sapiens_hsa041400.42626795
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42621702
93Metabolic pathways_Homo sapiens_hsa011000.41538639
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41463905
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40808237
96Measles_Homo sapiens_hsa051620.40643192
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39932201
98Oocyte meiosis_Homo sapiens_hsa041140.39146635
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36620385
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36580324
101Fatty acid degradation_Homo sapiens_hsa000710.36489822
102Arachidonic acid metabolism_Homo sapiens_hsa005900.35759855
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35232630
104Notch signaling pathway_Homo sapiens_hsa043300.34935538
105Alcoholism_Homo sapiens_hsa050340.34828673
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33957178
107Acute myeloid leukemia_Homo sapiens_hsa052210.33528583
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33409967
109Arginine biosynthesis_Homo sapiens_hsa002200.33254267
110Tyrosine metabolism_Homo sapiens_hsa003500.32313566
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32302125
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31737256
113Arginine and proline metabolism_Homo sapiens_hsa003300.31242128
114Other glycan degradation_Homo sapiens_hsa005110.31004390
115Caffeine metabolism_Homo sapiens_hsa002320.30834050
116Mineral absorption_Homo sapiens_hsa049780.29360732
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.29085917
118Bladder cancer_Homo sapiens_hsa052190.28971138
119Small cell lung cancer_Homo sapiens_hsa052220.24395388
120HIF-1 signaling pathway_Homo sapiens_hsa040660.24327882
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.22845828
122Hematopoietic cell lineage_Homo sapiens_hsa046400.22275444
123Hepatitis B_Homo sapiens_hsa051610.21303875
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20414813
125Leishmaniasis_Homo sapiens_hsa051400.18164136
126Influenza A_Homo sapiens_hsa051640.17644626
127Cardiac muscle contraction_Homo sapiens_hsa042600.17446567
128Hippo signaling pathway_Homo sapiens_hsa043900.15108754
129Lysosome_Homo sapiens_hsa041420.15088364
130Viral myocarditis_Homo sapiens_hsa054160.14574786
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14532639
132MicroRNAs in cancer_Homo sapiens_hsa052060.13438073
133B cell receptor signaling pathway_Homo sapiens_hsa046620.12526342
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12509977
135Linoleic acid metabolism_Homo sapiens_hsa005910.11945384
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11922658
137Vibrio cholerae infection_Homo sapiens_hsa051100.10341198
138Colorectal cancer_Homo sapiens_hsa052100.08996213

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