EIF2B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.47882284
2purine nucleobase biosynthetic process (GO:0009113)5.08863926
3nucleobase biosynthetic process (GO:0046112)5.04754998
4proteasome assembly (GO:0043248)5.02183687
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.69751683
6ATP synthesis coupled proton transport (GO:0015986)4.69751683
7ribosome assembly (GO:0042255)4.66153662
8protein complex biogenesis (GO:0070271)4.53118300
9maturation of SSU-rRNA (GO:0030490)4.45676269
10formation of translation preinitiation complex (GO:0001731)4.41589585
11cullin deneddylation (GO:0010388)4.41320428
12ribosome biogenesis (GO:0042254)4.39219714
13mitochondrial respiratory chain complex assembly (GO:0033108)4.39034612
14chaperone-mediated protein transport (GO:0072321)4.30683001
15rRNA modification (GO:0000154)4.21891409
16protein deneddylation (GO:0000338)4.18635532
17mitotic metaphase plate congression (GO:0007080)4.18164545
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17729149
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15506843
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.15506843
21NADH dehydrogenase complex assembly (GO:0010257)4.15506843
22termination of RNA polymerase III transcription (GO:0006386)4.14709046
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.14709046
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11731788
25DNA replication checkpoint (GO:0000076)4.11346126
26DNA strand elongation involved in DNA replication (GO:0006271)4.07245380
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.07091721
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.02715833
29DNA replication initiation (GO:0006270)4.01513538
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01464933
317-methylguanosine mRNA capping (GO:0006370)4.01412824
32respiratory electron transport chain (GO:0022904)4.00319885
33ribonucleoprotein complex biogenesis (GO:0022613)3.98265831
34DNA deamination (GO:0045006)3.97837978
35spliceosomal snRNP assembly (GO:0000387)3.97699696
36ribosomal large subunit biogenesis (GO:0042273)3.97593924
37CENP-A containing nucleosome assembly (GO:0034080)3.96020320
38RNA capping (GO:0036260)3.94472795
397-methylguanosine RNA capping (GO:0009452)3.94472795
40electron transport chain (GO:0022900)3.91570132
41rRNA processing (GO:0006364)3.89898629
42DNA strand elongation (GO:0022616)3.85848787
43cytochrome complex assembly (GO:0017004)3.84798253
44maturation of 5.8S rRNA (GO:0000460)3.82952386
45chromatin remodeling at centromere (GO:0031055)3.82876716
46telomere maintenance via semi-conservative replication (GO:0032201)3.82753521
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.82282190
48respiratory chain complex IV assembly (GO:0008535)3.79486400
49termination of RNA polymerase I transcription (GO:0006363)3.79026263
50negative regulation of ligase activity (GO:0051352)3.77658893
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77658893
52rRNA metabolic process (GO:0016072)3.76671629
53transcription from RNA polymerase I promoter (GO:0006360)3.70452567
54oxidative phosphorylation (GO:0006119)3.69436750
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.59938514
56pseudouridine synthesis (GO:0001522)3.59584372
57transcription-coupled nucleotide-excision repair (GO:0006283)3.55647066
58IMP biosynthetic process (GO:0006188)3.55049678
59metaphase plate congression (GO:0051310)3.54528112
60telomere maintenance via recombination (GO:0000722)3.51980430
61regulation of cellular amino acid metabolic process (GO:0006521)3.51696174
62DNA replication-dependent nucleosome assembly (GO:0006335)3.50928786
63DNA replication-dependent nucleosome organization (GO:0034723)3.50928786
64spliceosomal complex assembly (GO:0000245)3.47563051
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46696605
66transcription initiation from RNA polymerase I promoter (GO:0006361)3.46516476
67positive regulation of ligase activity (GO:0051351)3.44638124
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44252250
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44252250
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44252250
71DNA replication-independent nucleosome organization (GO:0034724)3.42729495
72DNA replication-independent nucleosome assembly (GO:0006336)3.42729495
73peptidyl-histidine modification (GO:0018202)3.42064510
74protein targeting to mitochondrion (GO:0006626)3.41823888
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41726037
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41726037
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41127611
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.41127611
79protein neddylation (GO:0045116)3.39779664
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38066362
81rRNA methylation (GO:0031167)3.38061578
82mitotic nuclear envelope disassembly (GO:0007077)3.37421722
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.36582585
84DNA double-strand break processing (GO:0000729)3.35101843
85protein localization to kinetochore (GO:0034501)3.33764657
86cell cycle G1/S phase transition (GO:0044843)3.33645353
87G1/S transition of mitotic cell cycle (GO:0000082)3.33645353
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33591075
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32218435
90mitotic recombination (GO:0006312)3.32119104
91viral mRNA export from host cell nucleus (GO:0046784)3.30924675
92attachment of spindle microtubules to kinetochore (GO:0008608)3.29259908
93ribosomal small subunit assembly (GO:0000028)3.28030275
94cellular component biogenesis (GO:0044085)3.26611946
95histone exchange (GO:0043486)3.26556905
96telomere maintenance via telomere lengthening (GO:0010833)3.26504322
97establishment of protein localization to mitochondrion (GO:0072655)3.26051103
98protein localization to mitochondrion (GO:0070585)3.25523024
99protein-cofactor linkage (GO:0018065)3.24551358
100kinetochore organization (GO:0051383)3.24033445
101kinetochore assembly (GO:0051382)3.22896749
102tRNA aminoacylation (GO:0043039)3.22083535
103amino acid activation (GO:0043038)3.22083535
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.21669931
105tRNA aminoacylation for protein translation (GO:0006418)3.21089514
106inner mitochondrial membrane organization (GO:0007007)3.20393672
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19734295
108establishment of protein localization to mitochondrial membrane (GO:0090151)3.17895208
109establishment of integrated proviral latency (GO:0075713)3.15005409
110spindle checkpoint (GO:0031577)3.12978753
111DNA catabolic process, exonucleolytic (GO:0000738)3.12618417
112transcription elongation from RNA polymerase II promoter (GO:0006368)3.11609833
113ribosomal small subunit biogenesis (GO:0042274)3.11285107
114regulation of ligase activity (GO:0051340)3.10484155
115regulation of spindle organization (GO:0090224)3.09123794
116establishment of chromosome localization (GO:0051303)3.08614834
117IMP metabolic process (GO:0046040)3.08223328
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07464666
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07464666
120membrane disassembly (GO:0030397)3.07328862
121nuclear envelope disassembly (GO:0051081)3.07328862
122DNA-templated transcription, elongation (GO:0006354)3.06935351
123L-methionine salvage (GO:0071267)3.04705298
124L-methionine biosynthetic process (GO:0071265)3.04705298
125amino acid salvage (GO:0043102)3.04705298
126mitotic spindle checkpoint (GO:0071174)3.03030117
127regulation of mitochondrial translation (GO:0070129)3.02938795
128nucleotide-excision repair, DNA gap filling (GO:0006297)3.02788273
129DNA unwinding involved in DNA replication (GO:0006268)3.02567364
130negative regulation of sister chromatid segregation (GO:0033046)3.01847062
131negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01847062
132protein K6-linked ubiquitination (GO:0085020)3.00589207
133tRNA metabolic process (GO:0006399)2.94139614
134synapsis (GO:0007129)2.93118097
135ATP biosynthetic process (GO:0006754)2.91156875
136regulation of mitotic spindle checkpoint (GO:1903504)2.90340187
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90340187
138* translation (GO:0006412)2.87912574
139ubiquinone biosynthetic process (GO:0006744)2.87378154
140mitochondrial RNA metabolic process (GO:0000959)2.87200742
141aerobic respiration (GO:0009060)2.85292277
142purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.85171861
143purine nucleoside monophosphate biosynthetic process (GO:0009127)2.85171861
144tRNA processing (GO:0008033)2.82327007
145purine nucleoside triphosphate biosynthetic process (GO:0009145)2.79861937
146folic acid-containing compound biosynthetic process (GO:0009396)2.79686415
147DNA damage response, detection of DNA damage (GO:0042769)2.79123758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86956979
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.59626062
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42352478
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88610835
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.81741828
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81278224
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.60546276
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53092494
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29693073
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24088809
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19850791
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14637331
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13113134
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.12874412
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03348131
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80326357
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73047546
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.72964198
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71491096
20VDR_23849224_ChIP-Seq_CD4+_Human2.58785940
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55190212
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54011892
23XRN2_22483619_ChIP-Seq_HELA_Human2.42562543
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34502371
25DCP1A_22483619_ChIP-Seq_HELA_Human2.31201083
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29700688
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27304859
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24379589
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23900618
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22919190
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.13817865
32GABP_19822575_ChIP-Seq_HepG2_Human2.12509988
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05092727
34AR_21909140_ChIP-Seq_LNCAP_Human1.98325274
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98033960
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97856475
37ELK1_19687146_ChIP-ChIP_HELA_Human1.97381244
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95815526
39TTF2_22483619_ChIP-Seq_HELA_Human1.94025981
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.93208574
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90817386
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.87370300
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86656088
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82060153
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76620870
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69493426
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68625341
48ZNF274_21170338_ChIP-Seq_K562_Hela1.61225392
49VDR_22108803_ChIP-Seq_LS180_Human1.61039781
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.60722431
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49927103
52KDM5A_27292631_Chip-Seq_BREAST_Human1.48550880
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47817104
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44987359
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43073118
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41957633
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41610217
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41016822
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37702920
60EWS_26573619_Chip-Seq_HEK293_Human1.36167556
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.29409813
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.28431764
63CIITA_25753668_ChIP-Seq_RAJI_Human1.27961748
64* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27827403
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25909812
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21372771
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20998445
68* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19343365
69IGF1R_20145208_ChIP-Seq_DFB_Human1.14165213
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13774533
71FUS_26573619_Chip-Seq_HEK293_Human1.13337877
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.12448958
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11812363
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11238452
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08282502
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07668929
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07020816
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06984434
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06926855
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.06086072
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05858039
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05491651
83MYC_18940864_ChIP-ChIP_HL60_Human1.05140655
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04080205
85TFEB_21752829_ChIP-Seq_HELA_Human1.04001066
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01349807
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01307093
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01307093
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01307093
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99894358
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.97768769
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.95411063
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94623713
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94595395
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93794371
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93634489
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93086946
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91683241
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87758445
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87436567
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86784053
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86516891
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86268133
104TP53_22573176_ChIP-Seq_HFKS_Human0.85518251
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.84893449
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84031388
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82702217
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81210197
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79986306
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79742042
111HTT_18923047_ChIP-ChIP_STHdh_Human0.79620700
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.79087660
113IRF1_19129219_ChIP-ChIP_H3396_Human0.77814358
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76896467
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76442250
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75604865
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74349645
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74299451
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73904904
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.73484807
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73208686
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72324952
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.71294195
124P300_19829295_ChIP-Seq_ESCs_Human0.71014601
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69182282
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.68031719
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.67860406
128* PHF8_20622853_ChIP-Seq_HELA_Human0.65653837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.80857633
2MP0004957_abnormal_blastocyst_morpholog4.67342384
3MP0010094_abnormal_chromosome_stability4.56333090
4MP0003111_abnormal_nucleus_morphology4.56026094
5MP0003077_abnormal_cell_cycle3.93011622
6MP0008058_abnormal_DNA_repair3.87701667
7MP0008057_abnormal_DNA_replication3.84694244
8MP0008932_abnormal_embryonic_tissue3.13197991
9MP0003718_maternal_effect3.06185110
10MP0002837_dystrophic_cardiac_calcinosis3.05926833
11MP0003123_paternal_imprinting2.94428257
12MP0003786_premature_aging2.89775865
13MP0008007_abnormal_cellular_replicative2.76967553
14MP0004145_abnormal_muscle_electrophysio2.55331247
15MP0000372_irregular_coat_pigmentation2.43884933
16MP0001730_embryonic_growth_arrest2.33542639
17MP0003806_abnormal_nucleotide_metabolis2.24318705
18MP0008877_abnormal_DNA_methylation2.17244579
19MP0003646_muscle_fatigue2.16708760
20MP0000749_muscle_degeneration2.16469517
21MP0008260_abnormal_autophagy2.05701371
22MP0000350_abnormal_cell_proliferation2.01724625
23MP0004215_abnormal_myocardial_fiber1.92401634
24MP0002396_abnormal_hematopoietic_system1.88618235
25MP0004084_abnormal_cardiac_muscle1.88265785
26MP0003315_abnormal_perineum_morphology1.69447711
27MP0005380_embryogenesis_phenotype1.68910615
28MP0001672_abnormal_embryogenesis/_devel1.68910615
29MP0006072_abnormal_retinal_apoptosis1.67738528
30MP0001697_abnormal_embryo_size1.64050242
31MP0002080_prenatal_lethality1.51097026
32MP0002234_abnormal_pharynx_morphology1.49448828
33MP0003984_embryonic_growth_retardation1.49404798
34MP0002088_abnormal_embryonic_growth/wei1.44995182
35MP0003136_yellow_coat_color1.44866510
36MP0003195_calcinosis1.44498482
37MP0003186_abnormal_redox_activity1.41614093
38MP0002085_abnormal_embryonic_tissue1.41073511
39MP0003567_abnormal_fetal_cardiomyocyte1.40938454
40MP0006292_abnormal_olfactory_placode1.37224026
41MP0002210_abnormal_sex_determination1.32924823
42MP0004036_abnormal_muscle_relaxation1.30962980
43MP0001529_abnormal_vocalization1.29172422
44MP0003941_abnormal_skin_development1.27195662
45MP0010030_abnormal_orbit_morphology1.26750747
46MP0000313_abnormal_cell_death1.22626449
47MP0008775_abnormal_heart_ventricle1.20659997
48MP0004147_increased_porphyrin_level1.20029379
49MP0009333_abnormal_splenocyte_physiolog1.17449098
50MP0002084_abnormal_developmental_patter1.17425536
51MP0003121_genomic_imprinting1.15501652
52MP0002160_abnormal_reproductive_system1.13794139
53MP0000490_abnormal_crypts_of1.13295076
54MP0005330_cardiomyopathy1.13052880
55MP0001145_abnormal_male_reproductive1.12693216
56MP0010307_abnormal_tumor_latency1.09560228
57MP0001542_abnormal_bone_strength1.09526369
58MP0003950_abnormal_plasma_membrane1.09062612
59MP0005253_abnormal_eye_physiology1.08512841
60MP0000751_myopathy1.08243763
61MP0003937_abnormal_limbs/digits/tail_de1.08073118
62MP0002269_muscular_atrophy1.06266517
63MP0004197_abnormal_fetal_growth/weight/1.05712122
64MP0003011_delayed_dark_adaptation1.04960566
65MP0002086_abnormal_extraembryonic_tissu1.03640325
66MP0001929_abnormal_gametogenesis1.02968824
67MP0008872_abnormal_physiological_respon1.01414318
68MP0009046_muscle_twitch1.01036121
69MP0005084_abnormal_gallbladder_morpholo1.00421787
70MP0006035_abnormal_mitochondrial_morpho1.00134800
71MP0000653_abnormal_sex_gland0.98503835
72MP0000358_abnormal_cell_content/0.98430997
73MP0003137_abnormal_impulse_conducting0.98411834
74MP0009697_abnormal_copulation0.98009350
75MP0005645_abnormal_hypothalamus_physiol0.97614476
76MP0002938_white_spotting0.97364372
77MP0001293_anophthalmia0.96932642
78MP0002102_abnormal_ear_morphology0.96888179
79MP0006036_abnormal_mitochondrial_physio0.96698402
80MP0001727_abnormal_embryo_implantation0.95126543
81MP0005332_abnormal_amino_acid0.95045317
82MP0002111_abnormal_tail_morphology0.94763158
83MP0008875_abnormal_xenobiotic_pharmacok0.94454663
84MP0002019_abnormal_tumor_incidence0.93001451
85MP0010352_gastrointestinal_tract_polyps0.92773945
86MP0004142_abnormal_muscle_tone0.92568114
87MP0005551_abnormal_eye_electrophysiolog0.91424927
88MP0002132_abnormal_respiratory_system0.91362084
89MP0005389_reproductive_system_phenotype0.91268341
90MP0001661_extended_life_span0.88715984
91MP0003221_abnormal_cardiomyocyte_apopto0.88684126
92MP0005395_other_phenotype0.87830889
93MP0005367_renal/urinary_system_phenotyp0.87647840
94MP0000516_abnormal_urinary_system0.87647840
95MP0003890_abnormal_embryonic-extraembry0.86852634
96MP0006276_abnormal_autonomic_nervous0.83301676
97MP0002736_abnormal_nociception_after0.81327661
98MP0005384_cellular_phenotype0.80815499
99MP0005075_abnormal_melanosome_morpholog0.80258854
100MP0002163_abnormal_gland_morphology0.80225555
101MP0005503_abnormal_tendon_morphology0.80144677
102MP0005171_absent_coat_pigmentation0.80034621
103MP0008995_early_reproductive_senescence0.78716809
104MP0002095_abnormal_skin_pigmentation0.77106907
105MP0002751_abnormal_autonomic_nervous0.76319634
106MP0004133_heterotaxia0.76317063
107MP0001119_abnormal_female_reproductive0.76033118
108MP0002653_abnormal_ependyma_morphology0.75822154
109MP0000750_abnormal_muscle_regeneration0.75606076
110MP0003938_abnormal_ear_development0.73156117
111MP0005410_abnormal_fertilization0.71365546
112MP0002090_abnormal_vision0.69343933
113MP0002127_abnormal_cardiovascular_syste0.69003161
114MP0001286_abnormal_eye_development0.68975477
115MP0002106_abnormal_muscle_physiology0.67947435
116MP0009379_abnormal_foot_pigmentation0.67737243
117MP0001188_hyperpigmentation0.67711625
118MP0005620_abnormal_muscle_contractility0.67289635
119MP0005266_abnormal_metabolism0.67032534
120MP0000566_synostosis0.66976689
121MP0005636_abnormal_mineral_homeostasis0.66578638
122MP0005621_abnormal_cell_physiology0.66309389
123MP0008789_abnormal_olfactory_epithelium0.66287656
124MP0003698_abnormal_male_reproductive0.66129108
125MP0005408_hypopigmentation0.65282264
126MP0009672_abnormal_birth_weight0.64967102
127MP0001984_abnormal_olfaction0.64743821
128MP0005379_endocrine/exocrine_gland_phen0.64547846
129MP0000747_muscle_weakness0.64150079
130MP0002114_abnormal_axial_skeleton0.62761126
131MP0003119_abnormal_digestive_system0.62607185
132MP0001919_abnormal_reproductive_system0.62386727
133MP0003755_abnormal_palate_morphology0.62201435
134MP0006054_spinal_hemorrhage0.60348245
135MP0002277_abnormal_respiratory_mucosa0.58980521
136MP0003656_abnormal_erythrocyte_physiolo0.58822449
137MP0001764_abnormal_homeostasis0.58725215
138MP0000428_abnormal_craniofacial_morphol0.58628837
139MP0003936_abnormal_reproductive_system0.58289156
140MP0000049_abnormal_middle_ear0.57751476
141MP0002638_abnormal_pupillary_reflex0.56714822
142MP0000537_abnormal_urethra_morphology0.56156409
143MP0001905_abnormal_dopamine_level0.55781160

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.63612938
2Breast hypoplasia (HP:0003187)4.62862994
3Acute encephalopathy (HP:0006846)4.60402381
4Progressive macrocephaly (HP:0004481)4.25741175
5* Cerebral hypomyelination (HP:0006808)4.02083945
6Rough bone trabeculation (HP:0100670)3.90175130
7Carpal bone hypoplasia (HP:0001498)3.86756943
8Cerebral edema (HP:0002181)3.48037805
9Chromsome breakage (HP:0040012)3.45043257
10Irregular epiphyses (HP:0010582)3.39789808
11Renal Fanconi syndrome (HP:0001994)3.37701845
12Degeneration of anterior horn cells (HP:0002398)3.30991763
13Abnormality of the anterior horn cell (HP:0006802)3.30991763
14Patellar aplasia (HP:0006443)3.30770612
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30283136
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26605278
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26605278
18Oral leukoplakia (HP:0002745)3.20204760
19Aplasia/Hypoplasia of the patella (HP:0006498)3.19856813
20Lactic acidosis (HP:0003128)3.18790240
21Reticulocytopenia (HP:0001896)3.15782669
22Absent radius (HP:0003974)3.09461788
23Increased intramyocellular lipid droplets (HP:0012240)3.07179561
24Abnormal trabecular bone morphology (HP:0100671)3.03972360
25Abnormality of the preputium (HP:0100587)3.01125186
26Impulsivity (HP:0100710)3.00645535
27Meckel diverticulum (HP:0002245)3.00198955
28Abnormality of glycolysis (HP:0004366)2.93723187
29Increased serum pyruvate (HP:0003542)2.93723187
30Aplasia involving forearm bones (HP:0009822)2.89952908
31Absent forearm bone (HP:0003953)2.89952908
32Abnormality of the ileum (HP:0001549)2.88401356
33Exercise intolerance (HP:0003546)2.86641796
34Abnormality of cells of the erythroid lineage (HP:0012130)2.86500735
35Methylmalonic acidemia (HP:0002912)2.86135574
36Respiratory failure (HP:0002878)2.82064169
37Abnormal number of erythroid precursors (HP:0012131)2.76835187
38Abnormality of the labia minora (HP:0012880)2.76403956
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72807146
40Aplastic anemia (HP:0001915)2.68688643
41Abnormality of chromosome stability (HP:0003220)2.67402112
42Ureteral duplication (HP:0000073)2.60272635
43Selective tooth agenesis (HP:0001592)2.58410550
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.57604760
453-Methylglutaconic aciduria (HP:0003535)2.56720802
46Horseshoe kidney (HP:0000085)2.56355570
47Increased muscle lipid content (HP:0009058)2.55563311
48Premature graying of hair (HP:0002216)2.50929855
49Exertional dyspnea (HP:0002875)2.50320360
50Abnormality of alanine metabolism (HP:0010916)2.49471759
51Hyperalaninemia (HP:0003348)2.49471759
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49471759
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.49149027
54Nemaline bodies (HP:0003798)2.47903952
55Abnormality of methionine metabolism (HP:0010901)2.47016156
56Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46281038
57Absent epiphyses (HP:0010577)2.46281038
58Increased serum lactate (HP:0002151)2.45682571
59Macrocytic anemia (HP:0001972)2.45251361
60Methylmalonic aciduria (HP:0012120)2.44735704
61Bone marrow hypocellularity (HP:0005528)2.38356988
62Leukodystrophy (HP:0002415)2.36085630
63* CNS hypomyelination (HP:0003429)2.35444158
64Abnormal protein glycosylation (HP:0012346)2.34326446
65Abnormal glycosylation (HP:0012345)2.34326446
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34326446
67Abnormal protein N-linked glycosylation (HP:0012347)2.34326446
68Microvesicular hepatic steatosis (HP:0001414)2.33796855
69Duplicated collecting system (HP:0000081)2.33368790
70Microretrognathia (HP:0000308)2.32534161
71Increased CSF lactate (HP:0002490)2.32441519
72Increased hepatocellular lipid droplets (HP:0006565)2.30932499
73Small intestinal stenosis (HP:0012848)2.30593498
74Duodenal stenosis (HP:0100867)2.30593498
75Glossoptosis (HP:0000162)2.29968450
76* Secondary amenorrhea (HP:0000869)2.28519217
77Abnormality of the umbilical cord (HP:0010881)2.26880089
78Hepatocellular necrosis (HP:0001404)2.26339843
79Mitochondrial inheritance (HP:0001427)2.24912238
80Trismus (HP:0000211)2.24710572
81Absent thumb (HP:0009777)2.23210794
82Muscle fiber inclusion bodies (HP:0100299)2.22642048
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22562454
84Exercise-induced muscle cramps (HP:0003710)2.21961034
85Acute necrotizing encephalopathy (HP:0006965)2.21920792
86* Lethargy (HP:0001254)2.20569638
87Optic disc pallor (HP:0000543)2.19377329
88Sparse eyelashes (HP:0000653)2.17762840
89Adrenal hypoplasia (HP:0000835)2.17110898
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15330403
91Type I transferrin isoform profile (HP:0003642)2.14583095
92Medulloblastoma (HP:0002885)2.14581036
93Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12835948
94Megaloblastic anemia (HP:0001889)2.12677310
95Agnosia (HP:0010524)2.12259253
96Hypoglycemic coma (HP:0001325)2.06984477
97Abnormality of serum amino acid levels (HP:0003112)2.06330536
98Triphalangeal thumb (HP:0001199)2.06220820
99Supernumerary spleens (HP:0009799)2.06213489
100Hepatic necrosis (HP:0002605)2.05294581
101* CNS demyelination (HP:0007305)2.04695514
102Cellular immunodeficiency (HP:0005374)2.04223888
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03985274
104Abnormal lung lobation (HP:0002101)2.03969438
105Sloping forehead (HP:0000340)2.03782335
106Abnormality of the pons (HP:0007361)2.03201965
107Reduced antithrombin III activity (HP:0001976)2.01207534
108Abnormality of the renal collecting system (HP:0004742)2.00854705
109Patent foramen ovale (HP:0001655)2.00498780
110Small epiphyses (HP:0010585)1.99494247
111Hypoplasia of the pons (HP:0012110)1.98675998
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97697504
113Lipid accumulation in hepatocytes (HP:0006561)1.97301137
114Abnormality of renal resorption (HP:0011038)1.96080438
115Neoplasm of the pancreas (HP:0002894)1.95945474
116Neoplasm of the adrenal gland (HP:0100631)1.94775094
117Pancreatic cysts (HP:0001737)1.94766608
118Amniotic constriction ring (HP:0009775)1.94592071
119Abnormality of placental membranes (HP:0011409)1.94592071
120Congenital, generalized hypertrichosis (HP:0004540)1.94581187
121Colon cancer (HP:0003003)1.94370916
122Hypoplasia of the radius (HP:0002984)1.93222940
12311 pairs of ribs (HP:0000878)1.92753607
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92514849
125Myelodysplasia (HP:0002863)1.92473002
126Abnormality of the duodenum (HP:0002246)1.92398931
127Pallor (HP:0000980)1.91926160
128Hyperglycinemia (HP:0002154)1.88006941
129Pancytopenia (HP:0001876)1.87346491
130Abnormality of midbrain morphology (HP:0002418)1.87222625
131Molar tooth sign on MRI (HP:0002419)1.87222625
132Short thumb (HP:0009778)1.84695749
133Flat capital femoral epiphysis (HP:0003370)1.84477147
134Dicarboxylic aciduria (HP:0003215)1.83846646
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83846646
136Glycosuria (HP:0003076)1.83846543
137Abnormality of urine glucose concentration (HP:0011016)1.83846543
138Abnormal mitochondria in muscle tissue (HP:0008316)1.83389181
139Abnormal spermatogenesis (HP:0008669)1.81476402
140Sparse lateral eyebrow (HP:0005338)1.81348706
141Respiratory difficulties (HP:0002880)1.79669552
142Cleft eyelid (HP:0000625)1.79466088
143Facial cleft (HP:0002006)1.78565645
144Type 2 muscle fiber atrophy (HP:0003554)1.78037250
145Pancreatic fibrosis (HP:0100732)1.78012237
146Generalized aminoaciduria (HP:0002909)1.74374898
147Palpitations (HP:0001962)1.71845904
148Pancreatic islet-cell hyperplasia (HP:0004510)1.67896491
149Hyperglycinuria (HP:0003108)1.67340132
150* Emotional lability (HP:0000712)1.66470485
151Muscle fiber atrophy (HP:0100295)1.65210409
152Medial flaring of the eyebrow (HP:0010747)1.62724497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.63030003
2WEE14.29771255
3EIF2AK14.08643960
4TSSK63.28943931
5STK163.16685224
6VRK22.99836716
7SRPK12.86289522
8EIF2AK32.75817736
9PLK42.60614546
10CDC72.54894307
11MKNK12.29487683
12ZAK2.16573810
13TTK2.08263252
14NME22.06697724
15PLK32.04299194
16MKNK22.03489002
17PASK1.90089974
18BRSK21.89204305
19PLK11.87702117
20TRIM281.85813602
21VRK11.81783864
22EPHA21.78572543
23NUAK11.77925470
24NME11.77835742
25TESK21.71639866
26NEK11.66523611
27TLK11.63662622
28AKT31.62173044
29NEK21.60830963
30PNCK1.51638767
31AURKA1.46276984
32FRK1.45385964
33CCNB11.39198035
34WNK31.38859475
35ACVR1B1.38695022
36AURKB1.33731434
37MAP4K21.30904840
38PBK1.29219042
39CDK71.25617739
40CHEK21.23724761
41ATR1.20346666
42MUSK1.19117429
43STK38L1.18058040
44BRSK11.16282312
45PHKG21.14812394
46PHKG11.14812394
47MAP3K121.12618677
48EIF2AK21.12526584
49DYRK31.09110903
50TNIK0.95756475
51CHEK10.93270269
52MAPKAPK30.88561509
53RPS6KB20.88192885
54MAP3K40.87610537
55GRK10.86431356
56BRAF0.85616051
57BCR0.85312481
58IRAK30.84485044
59CDK80.84286394
60LIMK10.80901323
61INSRR0.80396213
62PDK20.78701105
63PDK40.78173596
64PDK30.78173596
65PIM20.78073212
66CSNK2A20.76371775
67MAP3K80.75247993
68MAPK130.74582766
69CSNK2A10.74460919
70MAPKAPK50.71456943
71DYRK20.71131927
72PAK10.70878973
73CSNK1G20.70380669
74MST40.70168142
75TESK10.66698615
76CDK40.65866747
77TAF10.65189883
78PRKCI0.64821387
79ATM0.63140012
80RPS6KA40.60517835
81MAP2K70.60186502
82CDK20.59782844
83STK240.58917553
84DAPK30.57010596
85STK40.55387139
86BCKDK0.52004857
87MINK10.52002292
88CDK10.51832525
89CSNK1A1L0.51571062
90RPS6KA50.51471740
91PRKCG0.50906445
92PAK40.49759158
93TGFBR10.49152346
94MELK0.47717764
95CSNK1G30.46158130
96PIM10.44694163
97PAK30.44558731
98NEK60.44438597
99PLK20.43451562
100ABL20.42113375
101PRKCE0.41566143
102OXSR10.41409305
103STK100.41141178
104CSNK1E0.40905849
105MYLK0.40599538
106DAPK10.40231951
107STK30.36314277
108PKN10.34148197
109MAP3K30.33209189
110BMPR1B0.32238984
111FLT30.31787306
112ALK0.31748882
113CDK30.31452984
114ILK0.31177565
115PRKACB0.31033319
116OBSCN0.30241272
117IRAK40.29581165
118CLK10.29480421
119PINK10.27743428
120GRK70.27411084
121KDR0.27006871
122LATS20.24107810
123CSNK1G10.23903154
124BRD40.23040435
125PRKDC0.20966307
126ERBB30.19465111
127CSNK1A10.17697233
128SIK30.16888265
129CASK0.16363508
130CDK180.16205918
131ADRBK20.15737134
132MAP3K110.15202043
133CDK140.14977965

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.62781370
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33221864
3RNA polymerase_Homo sapiens_hsa030204.21201901
4DNA replication_Homo sapiens_hsa030303.96797003
5Mismatch repair_Homo sapiens_hsa034303.56761338
6Ribosome_Homo sapiens_hsa030103.32161258
7Spliceosome_Homo sapiens_hsa030403.10857295
8* RNA transport_Homo sapiens_hsa030133.06990073
9Homologous recombination_Homo sapiens_hsa034402.83894701
10Nucleotide excision repair_Homo sapiens_hsa034202.72129414
11Pyrimidine metabolism_Homo sapiens_hsa002402.69719093
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44902780
13Cell cycle_Homo sapiens_hsa041102.35076863
14Base excision repair_Homo sapiens_hsa034102.34305831
15Basal transcription factors_Homo sapiens_hsa030222.29949262
16Vitamin B6 metabolism_Homo sapiens_hsa007502.28257816
17One carbon pool by folate_Homo sapiens_hsa006702.20082383
18Non-homologous end-joining_Homo sapiens_hsa034502.16021938
19Fanconi anemia pathway_Homo sapiens_hsa034602.11128224
20Protein export_Homo sapiens_hsa030601.98700466
21Propanoate metabolism_Homo sapiens_hsa006401.90980309
22RNA degradation_Homo sapiens_hsa030181.88057622
23Purine metabolism_Homo sapiens_hsa002301.70262650
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62030230
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47498809
26mRNA surveillance pathway_Homo sapiens_hsa030151.45296735
27Oxidative phosphorylation_Homo sapiens_hsa001901.34793347
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33773515
29p53 signaling pathway_Homo sapiens_hsa041151.29733169
30Parkinsons disease_Homo sapiens_hsa050121.29472932
31Huntingtons disease_Homo sapiens_hsa050161.20776305
32Epstein-Barr virus infection_Homo sapiens_hsa051691.20681786
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14204454
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13791824
35Folate biosynthesis_Homo sapiens_hsa007901.13518206
36Butanoate metabolism_Homo sapiens_hsa006501.12918657
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98816185
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.95823203
39Oocyte meiosis_Homo sapiens_hsa041140.93881524
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90494749
41Fatty acid metabolism_Homo sapiens_hsa012120.87838892
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86361285
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85968308
44Regulation of autophagy_Homo sapiens_hsa041400.85138540
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83228360
46Glutathione metabolism_Homo sapiens_hsa004800.82544034
47Peroxisome_Homo sapiens_hsa041460.82494404
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81995600
49Sulfur metabolism_Homo sapiens_hsa009200.79957322
50Pentose phosphate pathway_Homo sapiens_hsa000300.78296246
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.73940282
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70586595
53Biosynthesis of amino acids_Homo sapiens_hsa012300.68926121
54Tryptophan metabolism_Homo sapiens_hsa003800.67338594
55Caffeine metabolism_Homo sapiens_hsa002320.66944786
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.65565275
57Systemic lupus erythematosus_Homo sapiens_hsa053220.65540346
58Tyrosine metabolism_Homo sapiens_hsa003500.64211657
59Alzheimers disease_Homo sapiens_hsa050100.62555303
60Fatty acid degradation_Homo sapiens_hsa000710.62197813
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59114491
62Arachidonic acid metabolism_Homo sapiens_hsa005900.58936677
63Collecting duct acid secretion_Homo sapiens_hsa049660.56592299
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55893510
65Nitrogen metabolism_Homo sapiens_hsa009100.55268914
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55078629
67Viral carcinogenesis_Homo sapiens_hsa052030.54607617
68Metabolic pathways_Homo sapiens_hsa011000.52475580
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51827480
70Fructose and mannose metabolism_Homo sapiens_hsa000510.50563051
71Antigen processing and presentation_Homo sapiens_hsa046120.48630761
72Selenocompound metabolism_Homo sapiens_hsa004500.48400246
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47859951
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47777043
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45503842
76beta-Alanine metabolism_Homo sapiens_hsa004100.45408116
77Sulfur relay system_Homo sapiens_hsa041220.42830142
78Carbon metabolism_Homo sapiens_hsa012000.42438851
79Arginine and proline metabolism_Homo sapiens_hsa003300.40285467
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.39846906
81Herpes simplex infection_Homo sapiens_hsa051680.39645357
82Steroid biosynthesis_Homo sapiens_hsa001000.37325558
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.36612490
84Linoleic acid metabolism_Homo sapiens_hsa005910.35239491
85Fatty acid elongation_Homo sapiens_hsa000620.34225037
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34209029
87Arginine biosynthesis_Homo sapiens_hsa002200.33299706
88HTLV-I infection_Homo sapiens_hsa051660.30288867
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29931626
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29766657
91TGF-beta signaling pathway_Homo sapiens_hsa043500.29598489
92Olfactory transduction_Homo sapiens_hsa047400.28481217
93N-Glycan biosynthesis_Homo sapiens_hsa005100.26916757
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26555984
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25903369
96Chemical carcinogenesis_Homo sapiens_hsa052040.25187362
97Sphingolipid metabolism_Homo sapiens_hsa006000.24217341
98Vitamin digestion and absorption_Homo sapiens_hsa049770.23948518
99Legionellosis_Homo sapiens_hsa051340.23705060
100Lysine degradation_Homo sapiens_hsa003100.18931088
101Hippo signaling pathway_Homo sapiens_hsa043900.18579535
102Galactose metabolism_Homo sapiens_hsa000520.16207230
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15871414
104Retinol metabolism_Homo sapiens_hsa008300.15836219
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15397913
106Hedgehog signaling pathway_Homo sapiens_hsa043400.14893731
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14547512
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14440110
109Alcoholism_Homo sapiens_hsa050340.14314757
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.14051792
111Renin-angiotensin system_Homo sapiens_hsa046140.13298104
112Ether lipid metabolism_Homo sapiens_hsa005650.13026242
113Thyroid cancer_Homo sapiens_hsa052160.13000066
114Phototransduction_Homo sapiens_hsa047440.12440312
115MicroRNAs in cancer_Homo sapiens_hsa052060.11339712
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10203274
117Fat digestion and absorption_Homo sapiens_hsa049750.08833469
118Phenylalanine metabolism_Homo sapiens_hsa003600.08697924
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08526852
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08402529
121Pyruvate metabolism_Homo sapiens_hsa006200.06531682
122Basal cell carcinoma_Homo sapiens_hsa052170.05285204
123HIF-1 signaling pathway_Homo sapiens_hsa040660.04812526
124Cardiac muscle contraction_Homo sapiens_hsa042600.04469249
125Vibrio cholerae infection_Homo sapiens_hsa051100.04264226
126Small cell lung cancer_Homo sapiens_hsa052220.02563588
127Tight junction_Homo sapiens_hsa045300.00015424
128PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0160287
129Apoptosis_Homo sapiens_hsa04210-0.0143954
130Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0141154
131Other glycan degradation_Homo sapiens_hsa00511-0.0005580

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