EIF2B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.09091354
2proteasome assembly (GO:0043248)4.98713687
3formation of translation preinitiation complex (GO:0001731)4.54019903
4maturation of SSU-rRNA (GO:0030490)4.38418781
5purine nucleobase biosynthetic process (GO:0009113)4.36937662
6nucleobase biosynthetic process (GO:0046112)4.36907391
7rRNA modification (GO:0000154)4.08409747
8DNA strand elongation involved in DNA replication (GO:0006271)4.05239900
9ribosome biogenesis (GO:0042254)4.04065588
10ribosome assembly (GO:0042255)3.97612461
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88164274
12protein complex biogenesis (GO:0070271)3.86247143
13DNA strand elongation (GO:0022616)3.85410745
14mitotic metaphase plate congression (GO:0007080)3.82282513
15DNA replication initiation (GO:0006270)3.79508856
16mitochondrial respiratory chain complex assembly (GO:0033108)3.78538815
17folic acid metabolic process (GO:0046655)3.78425362
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76117179
19DNA replication checkpoint (GO:0000076)3.75703627
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75101821
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74092952
22ribonucleoprotein complex biogenesis (GO:0022613)3.72447889
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71443976
24telomere maintenance via semi-conservative replication (GO:0032201)3.69805005
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69738999
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.69738999
27NADH dehydrogenase complex assembly (GO:0010257)3.69738999
28DNA damage response, detection of DNA damage (GO:0042769)3.64357102
29spliceosomal snRNP assembly (GO:0000387)3.62460500
30respiratory chain complex IV assembly (GO:0008535)3.62083265
31peptidyl-histidine modification (GO:0018202)3.60563310
32regulation of cellular amino acid metabolic process (GO:0006521)3.56275318
33ribosomal large subunit biogenesis (GO:0042273)3.56182501
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56069228
35negative regulation of ligase activity (GO:0051352)3.56069228
36protein deneddylation (GO:0000338)3.53560541
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53421768
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53421768
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.51995611
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51995611
41rRNA processing (GO:0006364)3.51766038
42ubiquinone biosynthetic process (GO:0006744)3.50835240
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.50647737
44termination of RNA polymerase III transcription (GO:0006386)3.50647737
45cullin deneddylation (GO:0010388)3.45387001
46cytochrome complex assembly (GO:0017004)3.44186002
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43606142
48ATP synthesis coupled proton transport (GO:0015986)3.43606142
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41282670
50rRNA metabolic process (GO:0016072)3.38881623
51mannosylation (GO:0097502)3.37596492
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35631711
53ribosomal small subunit biogenesis (GO:0042274)3.35242386
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.34830103
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34830103
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34774141
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34774141
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34774141
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34134059
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34134059
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30860034
62rRNA methylation (GO:0031167)3.30277899
63regulation of mitochondrial translation (GO:0070129)3.30242507
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.29896549
65ubiquinone metabolic process (GO:0006743)3.26284405
66DNA double-strand break processing (GO:0000729)3.26217307
67* L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.24620360
68* amino acid salvage (GO:0043102)3.24333113
69* L-methionine salvage (GO:0071267)3.24333113
70* L-methionine biosynthetic process (GO:0071265)3.24333113
71oxidative phosphorylation (GO:0006119)3.23934859
727-methylguanosine mRNA capping (GO:0006370)3.22179933
73DNA replication-dependent nucleosome assembly (GO:0006335)3.21541486
74DNA replication-dependent nucleosome organization (GO:0034723)3.21541486
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21215900
76* translational initiation (GO:0006413)3.20721921
77protein localization to kinetochore (GO:0034501)3.20396974
78positive regulation of ligase activity (GO:0051351)3.20391475
79cellular component biogenesis (GO:0044085)3.20372682
80protein targeting to mitochondrion (GO:0006626)3.20189365
81pseudouridine synthesis (GO:0001522)3.18784545
82ribosomal small subunit assembly (GO:0000028)3.18174371
83telomere maintenance via recombination (GO:0000722)3.16334478
84IMP biosynthetic process (GO:0006188)3.16025172
85maturation of 5.8S rRNA (GO:0000460)3.15770895
86tRNA modification (GO:0006400)3.15571261
87chaperone-mediated protein transport (GO:0072321)3.14934594
88viral transcription (GO:0019083)3.13859633
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13145843
90RNA capping (GO:0036260)3.12567206
917-methylguanosine RNA capping (GO:0009452)3.12567206
92translational termination (GO:0006415)3.11091598
93histone H2A acetylation (GO:0043968)3.09406222
94dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.09366275
95transcription-coupled nucleotide-excision repair (GO:0006283)3.09077257
96* translation (GO:0006412)3.08878626
97transcription from RNA polymerase I promoter (GO:0006360)3.08596246
98mitochondrial RNA metabolic process (GO:0000959)3.07380004
99establishment of protein localization to mitochondrial membrane (GO:0090151)3.06634281
100aspartate family amino acid catabolic process (GO:0009068)3.06291797
101metaphase plate congression (GO:0051310)3.05874566
102tRNA processing (GO:0008033)3.05442932
103translational elongation (GO:0006414)3.05048550
104glycine metabolic process (GO:0006544)3.03477233
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.02616072
106folic acid-containing compound biosynthetic process (GO:0009396)3.01970947
107branched-chain amino acid catabolic process (GO:0009083)3.01926135
108regulation of ubiquitin-protein transferase activity (GO:0051438)3.01767578
109termination of RNA polymerase I transcription (GO:0006363)3.01615550
110DNA catabolic process, exonucleolytic (GO:0000738)2.98119408
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.97681031
112protein localization to mitochondrion (GO:0070585)2.97381748
113CENP-A containing nucleosome assembly (GO:0034080)2.96539704
114tRNA metabolic process (GO:0006399)2.95985955
115platelet dense granule organization (GO:0060155)2.95721174
116chromatin remodeling at centromere (GO:0031055)2.93417564
117replication fork processing (GO:0031297)2.93382188
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92682572
119regulation of mitotic spindle checkpoint (GO:1903504)2.92682572
120mitotic nuclear envelope disassembly (GO:0007077)2.92263650
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90509363
122regulation of ligase activity (GO:0051340)2.90425120
123histone exchange (GO:0043486)2.90218707
124water-soluble vitamin biosynthetic process (GO:0042364)2.89683595
125telomere maintenance via telomere lengthening (GO:0010833)2.89331326
126G1/S transition of mitotic cell cycle (GO:0000082)2.88480214
127cell cycle G1/S phase transition (GO:0044843)2.88480214
128isotype switching (GO:0045190)2.85324304
129somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85324304
130somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85324304
131protein localization to chromosome, centromeric region (GO:0071459)2.84696908
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83908017
133respiratory electron transport chain (GO:0022904)2.83303749
134viral mRNA export from host cell nucleus (GO:0046784)2.83021826
135mitotic recombination (GO:0006312)2.82751297
136DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82632999
137establishment of protein localization to mitochondrion (GO:0072655)2.80556989
138spliceosomal complex assembly (GO:0000245)2.79991242
139metallo-sulfur cluster assembly (GO:0031163)2.79851505
140iron-sulfur cluster assembly (GO:0016226)2.79851505
141electron transport chain (GO:0022900)2.79532596
142regulation of helicase activity (GO:0051095)2.79197595
143DNA unwinding involved in DNA replication (GO:0006268)2.79085277
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.78141963
145guanosine-containing compound biosynthetic process (GO:1901070)2.78111327
146protein neddylation (GO:0045116)2.77870296
147base-excision repair, AP site formation (GO:0006285)2.76058892
148establishment of integrated proviral latency (GO:0075713)2.74394294
149positive regulation of cell cycle arrest (GO:0071158)2.73705021
150quinone biosynthetic process (GO:1901663)2.72695257
151DNA integration (GO:0015074)2.72070595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.04205498
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.15485664
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95745745
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68236325
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61775918
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.36857496
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.36005556
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.24155074
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10059219
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05208480
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01916328
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90542792
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80326777
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69785522
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63113954
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52724240
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52188107
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.49564930
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36973013
20XRN2_22483619_ChIP-Seq_HELA_Human2.29131926
21VDR_23849224_ChIP-Seq_CD4+_Human2.26782583
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24257936
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.21236145
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18874141
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17410417
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11877510
27ZNF274_21170338_ChIP-Seq_K562_Hela2.11145822
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10363017
29* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09576951
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.06280414
31GABP_19822575_ChIP-Seq_HepG2_Human2.04325907
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03414814
33* FOXP3_21729870_ChIP-Seq_TREG_Human2.02481507
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94324260
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.82723591
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82425551
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75953083
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73711249
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73001792
40* TTF2_22483619_ChIP-Seq_HELA_Human1.71603921
41* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69449579
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64975267
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62739210
44AR_21909140_ChIP-Seq_LNCAP_Human1.60301230
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58372405
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58336515
47* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55818089
48CIITA_25753668_ChIP-Seq_RAJI_Human1.53428270
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51922121
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47683917
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45460273
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45411797
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39142864
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38690729
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37976930
56* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35140721
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34928526
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34387566
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34092755
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30295012
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.26853325
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25366211
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23104191
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22165273
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16394143
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16241666
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15042708
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15040256
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14483053
70ELK1_19687146_ChIP-ChIP_HELA_Human1.14358157
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14248521
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11443091
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11211158
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10634948
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10595221
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10556378
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09004851
78ZNF263_19887448_ChIP-Seq_K562_Human1.05819763
79* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04203874
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.04049797
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04032519
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02473755
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02279998
84VDR_22108803_ChIP-Seq_LS180_Human1.00675962
85MYC_22102868_ChIP-Seq_BL_Human0.99172124
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99102976
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98967962
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98303241
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98227267
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.98117493
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97816436
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97411569
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97348664
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97148186
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95913365
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95157370
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94297958
98* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93965553
99IRF1_19129219_ChIP-ChIP_H3396_Human0.92117994
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91347314
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91087468
102IGF1R_20145208_ChIP-Seq_DFB_Human0.90890176
103TP53_22573176_ChIP-Seq_HFKS_Human0.90431854
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89846370
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89788108
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.89628481
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89078080
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87112917
109EWS_26573619_Chip-Seq_HEK293_Human0.86138807
110MYC_18940864_ChIP-ChIP_HL60_Human0.85763111
111TFEB_21752829_ChIP-Seq_HELA_Human0.85318600
112* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84577377
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83969188
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83884141
115ERA_21632823_ChIP-Seq_H3396_Human0.83507931
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83452616
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.82415650
118RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80983541
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.79927477
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78054627
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76331101
122AR_20517297_ChIP-Seq_VCAP_Human0.75872112
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.75233125
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74824721
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74717967
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.73878517
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73844909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.76836304
2MP0004957_abnormal_blastocyst_morpholog4.31708497
3MP0003111_abnormal_nucleus_morphology4.24742766
4MP0003806_abnormal_nucleotide_metabolis4.14059718
5MP0010094_abnormal_chromosome_stability3.62944456
6MP0003077_abnormal_cell_cycle3.44752632
7MP0008057_abnormal_DNA_replication2.93503899
8MP0003718_maternal_effect2.93473568
9MP0008058_abnormal_DNA_repair2.91416036
10MP0002653_abnormal_ependyma_morphology2.59987571
11MP0008932_abnormal_embryonic_tissue2.58090778
12MP0006036_abnormal_mitochondrial_physio2.38710922
13MP0002102_abnormal_ear_morphology2.29538721
14MP0003646_muscle_fatigue2.29412407
15MP0001730_embryonic_growth_arrest2.24314485
16MP0009840_abnormal_foam_cell2.16833128
17MP0002736_abnormal_nociception_after2.09518626
18MP0008007_abnormal_cellular_replicative1.94294354
19MP0003195_calcinosis1.89934850
20MP0003123_paternal_imprinting1.89903979
21MP0006072_abnormal_retinal_apoptosis1.88233596
22MP0003186_abnormal_redox_activity1.84050087
23MP0006035_abnormal_mitochondrial_morpho1.82536560
24MP0003786_premature_aging1.82259380
25MP0005499_abnormal_olfactory_system1.76525786
26MP0005394_taste/olfaction_phenotype1.76525786
27MP0005551_abnormal_eye_electrophysiolog1.75710210
28MP0005365_abnormal_bile_salt1.71257348
29MP0006054_spinal_hemorrhage1.70929514
30MP0005253_abnormal_eye_physiology1.69377323
31MP0008877_abnormal_DNA_methylation1.67152620
32MP0000350_abnormal_cell_proliferation1.67015824
33MP0003656_abnormal_erythrocyte_physiolo1.60475035
34MP0001764_abnormal_homeostasis1.59941895
35MP0001984_abnormal_olfaction1.57816730
36MP0002139_abnormal_hepatobiliary_system1.56153079
37MP0001672_abnormal_embryogenesis/_devel1.55288411
38MP0005380_embryogenesis_phenotype1.55288411
39MP0001968_abnormal_touch/_nociception1.53675894
40MP0003221_abnormal_cardiomyocyte_apopto1.51288305
41MP0002080_prenatal_lethality1.50003173
42MP0005085_abnormal_gallbladder_physiolo1.49157280
43MP0002254_reproductive_system_inflammat1.44924815
44MP0002234_abnormal_pharynx_morphology1.44859367
45MP0001697_abnormal_embryo_size1.43424306
46MP0002132_abnormal_respiratory_system1.41683367
47MP0001986_abnormal_taste_sensitivity1.40885191
48MP0003787_abnormal_imprinting1.39970415
49MP0004133_heterotaxia1.37148597
50MP0000372_irregular_coat_pigmentation1.35662157
51MP0003136_yellow_coat_color1.33536354
52MP0002269_muscular_atrophy1.32906215
53MP0002638_abnormal_pupillary_reflex1.32799894
54MP0003984_embryonic_growth_retardation1.31451273
55MP0003121_genomic_imprinting1.30483427
56MP0002088_abnormal_embryonic_growth/wei1.28243544
57MP0000750_abnormal_muscle_regeneration1.24247197
58MP0002938_white_spotting1.23064930
59MP0000313_abnormal_cell_death1.22724402
60MP0005330_cardiomyopathy1.22397924
61MP0004084_abnormal_cardiac_muscle1.22034053
62MP0004147_increased_porphyrin_level1.21913890
63MP0005266_abnormal_metabolism1.21410521
64MP0000358_abnormal_cell_content/1.21227192
65MP0002837_dystrophic_cardiac_calcinosis1.21058306
66MP0005083_abnormal_biliary_tract1.20132928
67MP0005332_abnormal_amino_acid1.19840111
68MP0006276_abnormal_autonomic_nervous1.18757893
69MP0005451_abnormal_body_composition1.18739110
70MP0001929_abnormal_gametogenesis1.18083334
71MP0002085_abnormal_embryonic_tissue1.18019820
72MP0005367_renal/urinary_system_phenotyp1.17794705
73MP0000516_abnormal_urinary_system1.17794705
74MP0003567_abnormal_fetal_cardiomyocyte1.17699223
75MP0002210_abnormal_sex_determination1.16285122
76MP0004145_abnormal_muscle_electrophysio1.12865861
77MP0002160_abnormal_reproductive_system1.11910939
78MP0005670_abnormal_white_adipose1.11202384
79MP0008872_abnormal_physiological_respon1.10884286
80MP0002396_abnormal_hematopoietic_system1.10665788
81MP0001661_extended_life_span1.08833798
82MP0004215_abnormal_myocardial_fiber1.07704561
83MP0009333_abnormal_splenocyte_physiolog1.07059185
84MP0002019_abnormal_tumor_incidence1.06892389
85MP0000049_abnormal_middle_ear1.06284078
86MP0005360_urolithiasis1.06022914
87MP0001145_abnormal_male_reproductive1.04670503
88MP0008260_abnormal_autophagy1.04378919
89MP0008995_early_reproductive_senescence1.03849688
90MP0003315_abnormal_perineum_morphology1.03785811
91MP0003122_maternal_imprinting1.01299013
92MP0001905_abnormal_dopamine_level1.01094512
93MP0002084_abnormal_developmental_patter0.98403235
94MP0001529_abnormal_vocalization0.97158782
95MP0003763_abnormal_thymus_physiology0.96443208
96MP0000749_muscle_degeneration0.96269432
97MP0005084_abnormal_gallbladder_morpholo0.95571107
98MP0003890_abnormal_embryonic-extraembry0.94287121
99MP0000490_abnormal_crypts_of0.94170949
100MP0005319_abnormal_enzyme/_coenzyme0.92022188
101MP0002086_abnormal_extraembryonic_tissu0.90593955
102MP0003119_abnormal_digestive_system0.90298413
103MP0005075_abnormal_melanosome_morpholog0.90161411
104MP0005646_abnormal_pituitary_gland0.90038588
105MP0000653_abnormal_sex_gland0.89956868
106MP0008789_abnormal_olfactory_epithelium0.89697810
107MP0006292_abnormal_olfactory_placode0.85745423
108MP0009780_abnormal_chondrocyte_physiolo0.85328354
109MP0004043_abnormal_pH_regulation0.85315610
110MP0005395_other_phenotype0.85006859
111MP0002163_abnormal_gland_morphology0.84732229
112MP0005389_reproductive_system_phenotype0.84061134
113MP0001324_abnormal_eye_pigmentation0.83283720
114MP0001666_abnormal_nutrient_absorption0.83118408
115MP0005391_vision/eye_phenotype0.82871683
116MP0002233_abnormal_nose_morphology0.81937128
117MP0003011_delayed_dark_adaptation0.81149732
118MP0005410_abnormal_fertilization0.81093408
119MP0003941_abnormal_skin_development0.79839131
120MP0001727_abnormal_embryo_implantation0.78508081
121MP0005195_abnormal_posterior_eye0.78233067
122MP0008875_abnormal_xenobiotic_pharmacok0.77343731
123MP0005636_abnormal_mineral_homeostasis0.76060429
124MP0003698_abnormal_male_reproductive0.75418158
125MP0004197_abnormal_fetal_growth/weight/0.74629354
126MP0003137_abnormal_impulse_conducting0.74068889
127MP0002127_abnormal_cardiovascular_syste0.73564410
128MP0000631_abnormal_neuroendocrine_gland0.73134875
129MP0009672_abnormal_birth_weight0.73000460
130MP0005376_homeostasis/metabolism_phenot0.70033683
131MP0004264_abnormal_extraembryonic_tissu0.69829253
132MP0004142_abnormal_muscle_tone0.69622998
133MP0004036_abnormal_muscle_relaxation0.67880249
134MP0005384_cellular_phenotype0.66383475
135MP0000647_abnormal_sebaceous_gland0.65763537
136MP0009379_abnormal_foot_pigmentation0.65599524
137MP0000747_muscle_weakness0.64224738
138MP0002161_abnormal_fertility/fecundity0.64146971
139MP0001293_anophthalmia0.63940772
140MP0010030_abnormal_orbit_morphology0.63749134
141MP0009643_abnormal_urine_homeostasis0.63624029
142MP0000598_abnormal_liver_morphology0.63446047
143MP0000609_abnormal_liver_physiology0.61394285
144MP0002722_abnormal_immune_system0.60328589

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.19040654
2Birth length less than 3rd percentile (HP:0003561)3.94158078
3Acute necrotizing encephalopathy (HP:0006965)3.83947869
4Increased serum pyruvate (HP:0003542)3.63351715
5Abnormality of glycolysis (HP:0004366)3.63351715
6Abnormal mitochondria in muscle tissue (HP:0008316)3.59002306
7Carpal bone hypoplasia (HP:0001498)3.55058250
8Multiple enchondromatosis (HP:0005701)3.54347826
9Acute encephalopathy (HP:0006846)3.51646933
10Hepatic necrosis (HP:0002605)3.46883865
11Oral leukoplakia (HP:0002745)3.46745386
12Hepatocellular necrosis (HP:0001404)3.45782694
13Mitochondrial inheritance (HP:0001427)3.37988465
14Increased CSF lactate (HP:0002490)3.37763235
15* Cerebral hypomyelination (HP:0006808)3.34500983
16Abnormality of cells of the erythroid lineage (HP:0012130)3.30290842
17Abnormal protein glycosylation (HP:0012346)3.25869675
18Abnormal glycosylation (HP:0012345)3.25869675
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.25869675
20Abnormal protein N-linked glycosylation (HP:0012347)3.25869675
21Abnormal number of erythroid precursors (HP:0012131)3.22316031
22Increased serum lactate (HP:0002151)3.20479037
23Type I transferrin isoform profile (HP:0003642)3.12202447
24Rough bone trabeculation (HP:0100670)3.11282813
25Hyperglycinemia (HP:0002154)3.07229118
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02416285
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02416285
28Cerebral edema (HP:0002181)3.01314956
29Progressive muscle weakness (HP:0003323)2.96525433
30Trismus (HP:0000211)2.85831104
31Abnormality of the anterior horn cell (HP:0006802)2.83535079
32Degeneration of anterior horn cells (HP:0002398)2.83535079
33Progressive macrocephaly (HP:0004481)2.79494636
34Lactic acidosis (HP:0003128)2.77218989
35Hyperglycinuria (HP:0003108)2.75499691
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71835265
373-Methylglutaconic aciduria (HP:0003535)2.69088934
38Macrocytic anemia (HP:0001972)2.68543838
39Methylmalonic aciduria (HP:0012120)2.68319147
40Renal Fanconi syndrome (HP:0001994)2.66215617
41Aplastic anemia (HP:0001915)2.65577425
42* CNS demyelination (HP:0007305)2.63353386
43* Lethargy (HP:0001254)2.61777702
44Abnormality of the labia minora (HP:0012880)2.61692015
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60462512
46Rhabdomyolysis (HP:0003201)2.58211262
47Opisthotonus (HP:0002179)2.55906339
48Patellar aplasia (HP:0006443)2.50953951
49Exercise intolerance (HP:0003546)2.50313729
50Microvesicular hepatic steatosis (HP:0001414)2.49523540
51Optic disc pallor (HP:0000543)2.48263969
52Reticulocytopenia (HP:0001896)2.48051685
53Methylmalonic acidemia (HP:0002912)2.47460733
54Aplasia/Hypoplasia of the patella (HP:0006498)2.45917011
55Progressive microcephaly (HP:0000253)2.44126147
56Abnormality of glycine metabolism (HP:0010895)2.42500117
57Abnormality of serine family amino acid metabolism (HP:0010894)2.42500117
58Medial flaring of the eyebrow (HP:0010747)2.42128705
59Pancreatic cysts (HP:0001737)2.41492019
60Abnormality of the heme biosynthetic pathway (HP:0010472)2.41400006
61Respiratory failure (HP:0002878)2.40164089
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40099065
63Lipid accumulation in hepatocytes (HP:0006561)2.40030357
64Nephrogenic diabetes insipidus (HP:0009806)2.35946384
65* Secondary amenorrhea (HP:0000869)2.34877942
66Increased hepatocellular lipid droplets (HP:0006565)2.34865142
67Dicarboxylic aciduria (HP:0003215)2.32424047
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32424047
69Impulsivity (HP:0100710)2.31997918
70Abnormality of serum amino acid levels (HP:0003112)2.30524019
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30208780
72* Premature ovarian failure (HP:0008209)2.29903159
73Selective tooth agenesis (HP:0001592)2.28855452
74* Emotional lability (HP:0000712)2.27977410
75Microretrognathia (HP:0000308)2.27831165
76Congenital primary aphakia (HP:0007707)2.25252826
77Bile duct proliferation (HP:0001408)2.24527356
78Abnormal biliary tract physiology (HP:0012439)2.24527356
79Pancreatic fibrosis (HP:0100732)2.20699759
80Abnormality of midbrain morphology (HP:0002418)2.20627858
81Molar tooth sign on MRI (HP:0002419)2.20627858
82Gait imbalance (HP:0002141)2.16135910
83Abnormal trabecular bone morphology (HP:0100671)2.15709487
84Gout (HP:0001997)2.13588659
85Megaloblastic anemia (HP:0001889)2.12656904
86Neonatal respiratory distress (HP:0002643)2.12574341
87Pendular nystagmus (HP:0012043)2.12445675
88True hermaphroditism (HP:0010459)2.08787288
89Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06028472
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06024696
91Abnormality of alanine metabolism (HP:0010916)2.06024696
92Hyperalaninemia (HP:0003348)2.06024696
93Testicular atrophy (HP:0000029)2.05779492
94Increased intramyocellular lipid droplets (HP:0012240)2.04575276
95Atrophy/Degeneration involving motor neurons (HP:0007373)2.04256615
96Areflexia of lower limbs (HP:0002522)2.03691245
97Attenuation of retinal blood vessels (HP:0007843)2.03654594
98Reduced antithrombin III activity (HP:0001976)2.03587667
99Ependymoma (HP:0002888)2.03268952
100Progressive external ophthalmoplegia (HP:0000590)2.02609761
101Hyperammonemia (HP:0001987)2.02420812
102* CNS hypomyelination (HP:0003429)2.02368261
103Prolonged neonatal jaundice (HP:0006579)2.01792558
104Sparse eyelashes (HP:0000653)2.00898624
105Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00523786
106Brushfield spots (HP:0001088)1.99435603
107Absent thumb (HP:0009777)1.99424358
108Abnormality of fatty-acid metabolism (HP:0004359)1.99337136
109Increased muscle lipid content (HP:0009058)1.98563297
110Colon cancer (HP:0003003)1.97391584
111Death in infancy (HP:0001522)1.96702051
112Respiratory difficulties (HP:0002880)1.96390335
113Congenital stationary night blindness (HP:0007642)1.96115360
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.95667557
115Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95318157
116Pallor (HP:0000980)1.94005265
117Hypobetalipoproteinemia (HP:0003563)1.93108313
118Abnormality of the preputium (HP:0100587)1.92951456
119* Blindness (HP:0000618)1.92745799
120Abnormality of pyrimidine metabolism (HP:0004353)1.92597845
121Leukodystrophy (HP:0002415)1.92515525
122Abnormality of the pons (HP:0007361)1.92095407
123Absent radius (HP:0003974)1.88151832
124Hypoplasia of the pons (HP:0012110)1.87531939
125* Unsteady gait (HP:0002317)1.87465608
126Type II lissencephaly (HP:0007260)1.87255390
127Pancytopenia (HP:0001876)1.84688035
128Prominent metopic ridge (HP:0005487)1.84025847
129Horseshoe kidney (HP:0000085)1.84011722
130Progressive inability to walk (HP:0002505)1.83171297
131Abolished electroretinogram (ERG) (HP:0000550)1.82119464
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82085251
133Nausea (HP:0002018)1.81630960
134Ketosis (HP:0001946)1.81290771
135Pancreatic islet-cell hyperplasia (HP:0004510)1.79065625
136Retinal dysplasia (HP:0007973)1.78474530
137Sloping forehead (HP:0000340)1.78157719
138Ragged-red muscle fibers (HP:0003200)1.78072058
139Ureteral duplication (HP:0000073)1.77605734
140Abnormality of the ileum (HP:0001549)1.77543170
141Meckel diverticulum (HP:0002245)1.77328333
142Type 2 muscle fiber atrophy (HP:0003554)1.76226159
143Sclerocornea (HP:0000647)1.75068479
144Abnormal rod and cone electroretinograms (HP:0008323)1.74977947
145Genital tract atresia (HP:0001827)1.72028870
146Small hand (HP:0200055)1.71748892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.59143531
2EIF2AK14.64559468
3VRK24.30907734
4WEE13.98203094
5STK163.71040067
6MAP4K23.44906034
7BMPR1B3.38466182
8BCKDK2.68510164
9TRIM282.64267848
10NUAK12.62310460
11NME22.54491459
12SRPK12.49485605
13PLK42.42322982
14TSSK62.39251821
15EIF2AK32.33590383
16TTK2.30311751
17NEK12.29996588
18TESK22.24915371
19CDC72.19563908
20WNK32.12693192
21NEK21.99966495
22PLK11.79409175
23NME11.77369237
24BRSK21.71999793
25EPHA21.69474000
26PDK31.69464845
27PDK41.69464845
28PASK1.64980301
29AKT31.64644387
30PNCK1.63536332
31FRK1.60061483
32GRK11.60036407
33TLK11.59864154
34BCR1.53751936
35AURKA1.53724248
36ADRBK21.53148847
37DYRK31.52130700
38CSNK1G11.49478389
39CSNK1G31.48823808
40VRK11.48350662
41KDR1.37263804
42BRAF1.32639444
43AURKB1.31983735
44RPS6KB21.26506215
45BRSK11.26463975
46MAP3K111.25477762
47CDK71.24449100
48MAPKAPK31.22755680
49MAP2K71.21812466
50SIK31.20456843
51PLK31.17441929
52CSNK1A1L1.17085630
53MST41.16278902
54MUSK1.11908007
55MAP2K31.10992346
56TESK11.08082136
57CHEK21.07709652
58CSNK1G21.07062662
59CCNB11.03855522
60ZAK1.00087699
61ATR0.96365689
62MAP3K80.93023810
63DYRK20.91573451
64PRKCI0.89858257
65PDK20.89053211
66TGFBR10.86738736
67CDK40.85005987
68MAP2K60.84424159
69IRAK30.81861907
70PLK20.81658643
71CHEK10.80636339
72PAK10.80614295
73MAPK130.78454716
74OBSCN0.74758590
75ACVR1B0.74076853
76EIF2AK20.73972935
77PAK40.72989423
78LATS20.72575054
79LMTK20.72062663
80CSNK2A10.71812235
81PIM20.70506579
82CSNK2A20.70401590
83STK100.68361817
84WNK40.66529611
85STK38L0.63818576
86MAP3K40.63758827
87INSRR0.62827981
88PINK10.60962356
89RPS6KA40.59401229
90TAOK30.58941209
91LIMK10.56473872
92CDK20.54964579
93MKNK10.53662219
94DAPK10.51643432
95ZAP700.51398308
96PAK30.49685821
97TAF10.49057282
98MAP2K20.47588625
99BLK0.46911976
100MAP3K30.46835861
101PRKCE0.46825472
102CSNK1A10.46127525
103PRKCG0.45863911
104MAPKAPK50.45754394
105MAPK110.45729255
106STK40.45573113
107GRK60.43976419
108PHKG20.43062626
109PHKG10.43062626
110ARAF0.40124639
111TIE10.39167786
112ERBB30.38631754
113ATM0.38539155
114MAP4K10.37914470
115CSNK1E0.37828762
116ABL20.37118855
117CDK90.37073968
118CDK10.36986512
119IRAK40.35723677
120CDK80.35577795
121MKNK20.35076364
122MINK10.32087252
123SCYL20.31523789
124CSNK1D0.30424484
125AKT20.29166351
126TNIK0.27205907
127FLT30.26702099
128CLK10.26641311
129RPS6KA50.26187849
130ALK0.25407404
131PIM10.25399253
132ILK0.24471109
133CDK30.23680622
134MYLK0.23484876
135PRKACA0.22830568
136TXK0.22792661
137DAPK30.18539962
138IRAK20.18032526
139RAF10.17988619
140TTN0.16403620
141PBK0.14414144
142CDK190.13722091
143CAMK2G0.12264727
144MAPK120.11583117
145MAPKAPK20.11249077

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.12321092
2DNA replication_Homo sapiens_hsa030303.55590902
3RNA polymerase_Homo sapiens_hsa030203.35754723
4Ribosome_Homo sapiens_hsa030103.20230714
5Mismatch repair_Homo sapiens_hsa034303.18630876
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14411370
7Spliceosome_Homo sapiens_hsa030402.56468032
8* RNA transport_Homo sapiens_hsa030132.49041137
9Pyrimidine metabolism_Homo sapiens_hsa002402.41653449
10Vitamin B6 metabolism_Homo sapiens_hsa007502.28298215
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26703627
12Base excision repair_Homo sapiens_hsa034102.16602316
13Homologous recombination_Homo sapiens_hsa034402.13812115
14Nucleotide excision repair_Homo sapiens_hsa034202.12557798
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09671454
16Oxidative phosphorylation_Homo sapiens_hsa001902.00819057
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98602265
18Parkinsons disease_Homo sapiens_hsa050121.94204432
19One carbon pool by folate_Homo sapiens_hsa006701.89972688
20Folate biosynthesis_Homo sapiens_hsa007901.88763279
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75721109
22Biosynthesis of amino acids_Homo sapiens_hsa012301.72866064
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70399737
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.69954350
25Huntingtons disease_Homo sapiens_hsa050161.59856546
26Cell cycle_Homo sapiens_hsa041101.56480336
27Basal transcription factors_Homo sapiens_hsa030221.55595094
28Sulfur relay system_Homo sapiens_hsa041221.54154924
29Carbon metabolism_Homo sapiens_hsa012001.51207623
30Pentose phosphate pathway_Homo sapiens_hsa000301.43302704
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.42122913
32Fanconi anemia pathway_Homo sapiens_hsa034601.34321107
33Purine metabolism_Homo sapiens_hsa002301.33469307
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.31758161
35Steroid biosynthesis_Homo sapiens_hsa001001.31468688
36RNA degradation_Homo sapiens_hsa030181.31429873
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28506637
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26319654
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17639329
40Pyruvate metabolism_Homo sapiens_hsa006201.15105735
41Non-homologous end-joining_Homo sapiens_hsa034501.13642550
42Selenocompound metabolism_Homo sapiens_hsa004501.12618508
43Glutathione metabolism_Homo sapiens_hsa004801.10951263
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10182740
45Fructose and mannose metabolism_Homo sapiens_hsa000511.08810829
46Alzheimers disease_Homo sapiens_hsa050101.04466381
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03599471
48Propanoate metabolism_Homo sapiens_hsa006401.02795075
49mRNA surveillance pathway_Homo sapiens_hsa030150.97438491
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97344039
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95028536
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94799656
53Arginine and proline metabolism_Homo sapiens_hsa003300.91670699
54Protein export_Homo sapiens_hsa030600.91383013
55Phototransduction_Homo sapiens_hsa047440.86515739
56N-Glycan biosynthesis_Homo sapiens_hsa005100.85318505
57p53 signaling pathway_Homo sapiens_hsa041150.83278758
58Epstein-Barr virus infection_Homo sapiens_hsa051690.80893757
59Nitrogen metabolism_Homo sapiens_hsa009100.78486628
60Metabolic pathways_Homo sapiens_hsa011000.77983113
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75127641
62Cardiac muscle contraction_Homo sapiens_hsa042600.73646296
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73261995
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68911487
65Peroxisome_Homo sapiens_hsa041460.66894655
66Fatty acid degradation_Homo sapiens_hsa000710.66121845
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65953751
68Sulfur metabolism_Homo sapiens_hsa009200.65251572
69Regulation of autophagy_Homo sapiens_hsa041400.63606568
70Galactose metabolism_Homo sapiens_hsa000520.62338861
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62192406
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.60083268
73Fatty acid elongation_Homo sapiens_hsa000620.57582180
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56738863
75beta-Alanine metabolism_Homo sapiens_hsa004100.54330233
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53150096
77Fat digestion and absorption_Homo sapiens_hsa049750.52133640
78Collecting duct acid secretion_Homo sapiens_hsa049660.52033480
79Arginine biosynthesis_Homo sapiens_hsa002200.50672298
80Lysine degradation_Homo sapiens_hsa003100.48711008
81Oocyte meiosis_Homo sapiens_hsa041140.46033315
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44186897
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44186482
84Fatty acid metabolism_Homo sapiens_hsa012120.43770694
85Tryptophan metabolism_Homo sapiens_hsa003800.43603224
86Butanoate metabolism_Homo sapiens_hsa006500.43574662
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42213595
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41423033
89Linoleic acid metabolism_Homo sapiens_hsa005910.40187209
90Systemic lupus erythematosus_Homo sapiens_hsa053220.39629886
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39079173
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38614539
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37404619
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37324064
95Chemical carcinogenesis_Homo sapiens_hsa052040.36083129
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35969948
97Phenylalanine metabolism_Homo sapiens_hsa003600.34366858
98Arachidonic acid metabolism_Homo sapiens_hsa005900.34094317
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.33296920
100Vitamin digestion and absorption_Homo sapiens_hsa049770.32287148
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31990539
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28024612
103Caffeine metabolism_Homo sapiens_hsa002320.27376668
104Ether lipid metabolism_Homo sapiens_hsa005650.27033462
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26790258
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26409628
107Antigen processing and presentation_Homo sapiens_hsa046120.23699193
108Glycerolipid metabolism_Homo sapiens_hsa005610.22728847
109Tyrosine metabolism_Homo sapiens_hsa003500.22355636
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.22321375
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21216966
112Viral carcinogenesis_Homo sapiens_hsa052030.20897052
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.20656318
114Retinol metabolism_Homo sapiens_hsa008300.18272342
115Primary immunodeficiency_Homo sapiens_hsa053400.15855742
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14602369

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