EIF2B5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.83019205
2folic acid-containing compound biosynthetic process (GO:0009396)4.82759466
3Golgi transport vesicle coating (GO:0048200)4.77460512
4COPI coating of Golgi vesicle (GO:0048205)4.77460512
5protein localization to kinetochore (GO:0034501)4.68632156
6DNA unwinding involved in DNA replication (GO:0006268)4.67204817
7DNA replication-dependent nucleosome organization (GO:0034723)4.57649944
8DNA replication-dependent nucleosome assembly (GO:0006335)4.57649944
9nuclear pore organization (GO:0006999)4.43711713
10nucleobase biosynthetic process (GO:0046112)4.41640690
11regulation of gene silencing by RNA (GO:0060966)4.39751588
12regulation of posttranscriptional gene silencing (GO:0060147)4.39751588
13regulation of gene silencing by miRNA (GO:0060964)4.39751588
14mitotic nuclear envelope disassembly (GO:0007077)4.17713344
15nuclear pore complex assembly (GO:0051292)4.16322952
16activation of MAPKKK activity (GO:0000185)4.15346536
17DNA replication initiation (GO:0006270)4.12945750
18purine nucleobase biosynthetic process (GO:0009113)4.06196033
19IMP biosynthetic process (GO:0006188)3.98957395
20regulation of translational fidelity (GO:0006450)3.97708739
21membrane disassembly (GO:0030397)3.92194774
22nuclear envelope disassembly (GO:0051081)3.92194774
23DNA strand elongation involved in DNA replication (GO:0006271)3.89361635
24protein localization to chromosome, centromeric region (GO:0071459)3.88959425
25ribosome biogenesis (GO:0042254)3.81816605
26mitotic sister chromatid segregation (GO:0000070)3.76825974
27negative regulation of erythrocyte differentiation (GO:0045647)3.73335050
28mitotic metaphase plate congression (GO:0007080)3.71839232
29ribosome assembly (GO:0042255)3.69537488
30maturation of SSU-rRNA (GO:0030490)3.69302665
31heterochromatin organization (GO:0070828)3.69120090
32DNA replication checkpoint (GO:0000076)3.66189056
33DNA strand elongation (GO:0022616)3.65804336
34folic acid metabolic process (GO:0046655)3.60018476
35DNA duplex unwinding (GO:0032508)3.52303205
36IMP metabolic process (GO:0046040)3.51571125
37DNA geometric change (GO:0032392)3.49984287
38regulation of translational termination (GO:0006449)3.49906312
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.47083010
40sister chromatid segregation (GO:0000819)3.46545020
41peptidyl-arginine omega-N-methylation (GO:0035247)3.45056729
42ribonucleoprotein complex biogenesis (GO:0022613)3.44349263
43positive regulation of gamma-delta T cell activation (GO:0046645)3.40394825
44pre-miRNA processing (GO:0031054)3.39623842
45histone arginine methylation (GO:0034969)3.39150737
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38068920
47ribosomal large subunit biogenesis (GO:0042273)3.37502878
48viral transcription (GO:0019083)3.36243256
49* translational initiation (GO:0006413)3.35755220
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35643605
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.35152724
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35152724
53translational termination (GO:0006415)3.34097437
54regulation of histone H3-K27 methylation (GO:0061085)3.33178841
55NIK/NF-kappaB signaling (GO:0038061)3.31608902
56chaperone-mediated protein complex assembly (GO:0051131)3.30275788
57protoporphyrinogen IX metabolic process (GO:0046501)3.26588037
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25124602
59mitotic G1 DNA damage checkpoint (GO:0031571)3.22499671
60proline biosynthetic process (GO:0006561)3.21720214
61telomere maintenance via semi-conservative replication (GO:0032201)3.20537007
62regulation of histone H3-K9 methylation (GO:0051570)3.19652089
63translational elongation (GO:0006414)3.19516020
64negative regulation of histone methylation (GO:0031061)3.17422185
65nuclear envelope organization (GO:0006998)3.15709198
66regulation of helicase activity (GO:0051095)3.13792856
67metaphase plate congression (GO:0051310)3.12508035
68protoporphyrinogen IX biosynthetic process (GO:0006782)3.12175077
69mitotic chromosome condensation (GO:0007076)3.11000696
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09388131
71chromatin assembly (GO:0031497)3.09276604
72pentose-phosphate shunt (GO:0006098)3.06020463
73pore complex assembly (GO:0046931)3.05163906
74spliceosomal snRNP assembly (GO:0000387)3.04990283
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04416254
76positive regulation of chromosome segregation (GO:0051984)3.01716642
77rRNA processing (GO:0006364)3.01415985
78pteridine-containing compound biosynthetic process (GO:0042559)3.01142615
79regulation of spindle organization (GO:0090224)3.00224063
80mannose metabolic process (GO:0006013)2.97816372
81dosage compensation (GO:0007549)2.92992312
82rRNA metabolic process (GO:0016072)2.91774969
83ribosomal small subunit assembly (GO:0000028)2.91285344
84rRNA transcription (GO:0009303)2.91082120
85ribosomal small subunit biogenesis (GO:0042274)2.89961882
86protein maturation by protein folding (GO:0022417)2.88987100
87leukocyte aggregation (GO:0070486)2.87027003
88peptidyl-arginine N-methylation (GO:0035246)2.86739008
89peptidyl-arginine methylation (GO:0018216)2.86739008
90regulation of hippo signaling (GO:0035330)2.86349996
91paraxial mesoderm development (GO:0048339)2.86141903
92DNA topological change (GO:0006265)2.85711688
93glycine metabolic process (GO:0006544)2.85673955
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84812959
95regulation of centrosome cycle (GO:0046605)2.82075356
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.81152198
97histone H2A monoubiquitination (GO:0035518)2.80923467
98negative regulation of chromosome segregation (GO:0051985)2.80280837
99tetrahydrofolate metabolic process (GO:0046653)2.78898206
100histone H4-K12 acetylation (GO:0043983)2.78736689
101mitotic G1/S transition checkpoint (GO:0044819)2.78533098
102tRNA aminoacylation for protein translation (GO:0006418)2.77923981
103determination of adult lifespan (GO:0008340)2.77346732
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76738920
105regulation of chromosome segregation (GO:0051983)2.76598684
106DNA conformation change (GO:0071103)2.75645865
107mitochondrial DNA metabolic process (GO:0032042)2.74326407
108regulation of telomere maintenance via telomerase (GO:0032210)2.74139980
109chromatin assembly or disassembly (GO:0006333)2.73968862
110regulation of nucleobase-containing compound transport (GO:0032239)2.73122097
111activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72969866
112establishment of apical/basal cell polarity (GO:0035089)2.71719626
113mRNA transport (GO:0051028)2.71526686
114positive regulation of nuclease activity (GO:0032075)2.70994414
115mitotic recombination (GO:0006312)2.70581622
116telomere maintenance via recombination (GO:0000722)2.69616786
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68671975
118trophectodermal cell differentiation (GO:0001829)2.68458581
119telomere maintenance via telomere lengthening (GO:0010833)2.67842213
120NADPH regeneration (GO:0006740)2.67430168
121negative regulation of mRNA processing (GO:0050686)2.67056013
122regulation of RNA export from nucleus (GO:0046831)2.66349338
123maternal placenta development (GO:0001893)2.66161997
124cellular protein complex disassembly (GO:0043624)2.65335668
125GDP-mannose metabolic process (GO:0019673)2.62201845
126cellular response to interleukin-4 (GO:0071353)2.61939804
127negative regulation of cell size (GO:0045792)2.58280671
128regulation of nuclease activity (GO:0032069)2.53723663
129oxaloacetate metabolic process (GO:0006107)2.53526114
130nucleobase-containing small molecule interconversion (GO:0015949)2.52965568
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52658913
132glycosphingolipid catabolic process (GO:0046479)2.52394460
133heme biosynthetic process (GO:0006783)2.49874586
134protein export from nucleus (GO:0006611)2.48825006
135positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.47079380
136negative regulation of myotube differentiation (GO:0010832)2.46340127
137regulation of gamma-delta T cell differentiation (GO:0045586)2.46283509
138NADH metabolic process (GO:0006734)2.44204856
139viral mRNA export from host cell nucleus (GO:0046784)2.42391481
140regulation of superoxide anion generation (GO:0032928)2.40903521
141entrainment of circadian clock by photoperiod (GO:0043153)2.40632416
142modulation by symbiont of host cellular process (GO:0044068)2.40206526
143endoplasmic reticulum unfolded protein response (GO:0030968)2.39918412
144ER-nucleus signaling pathway (GO:0006984)2.39666299
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39665002
146cellular protein complex localization (GO:0034629)2.39454589
147response to thyroid hormone (GO:0097066)2.39060926
148histone H4 deacetylation (GO:0070933)2.37306933
149glucose catabolic process (GO:0006007)2.36617379
150protein localization to endosome (GO:0036010)2.36594589
151positive regulation of B cell differentiation (GO:0045579)2.36523060
152regulation of gamma-delta T cell activation (GO:0046643)2.35147864
153purine nucleotide salvage (GO:0032261)2.35015110
154positive regulation of keratinocyte differentiation (GO:0045618)2.34435165
155regulation of DNA damage checkpoint (GO:2000001)2.33849960
156pinocytosis (GO:0006907)2.32995752
157negative regulation of necroptotic process (GO:0060546)2.30969074
158viral life cycle (GO:0019058)2.30482608
159response to interleukin-4 (GO:0070670)2.29671177
160negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29525826
161nucleosome disassembly (GO:0006337)2.26869263
162protein-DNA complex disassembly (GO:0032986)2.26869263
163UV protection (GO:0009650)2.25084340
164porphyrin-containing compound biosynthetic process (GO:0006779)2.24862196
165tricarboxylic acid metabolic process (GO:0072350)2.24350111
166N-acetylneuraminate metabolic process (GO:0006054)2.24335547
167B cell receptor signaling pathway (GO:0050853)2.23820227
168thymic T cell selection (GO:0045061)2.23493541
1693-UTR-mediated mRNA stabilization (GO:0070935)2.23043984
170negative regulation of mRNA metabolic process (GO:1903312)2.22754336
171glycolipid catabolic process (GO:0019377)2.22328107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46405685
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06244458
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.76811286
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58943598
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12099005
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94837159
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65612381
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56598224
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56161073
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28726120
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.23353064
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22845975
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21437990
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16233403
15XRN2_22483619_ChIP-Seq_HELA_Human2.12874801
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06233228
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.03355031
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03062038
19NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95353055
20AR_21909140_ChIP-Seq_LNCAP_Human1.93303742
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.93065279
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92428632
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91928151
24* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89293612
25* MYC_22102868_ChIP-Seq_BL_Human1.88169374
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84902526
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84902526
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84902526
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84151679
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81063123
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80221527
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79402984
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.78476975
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76495165
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74726091
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74550188
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72891013
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71224344
39* LXR_22292898_ChIP-Seq_THP-1_Human1.70395244
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.65102915
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.64324030
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63748979
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63424591
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59978045
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59920545
46DCP1A_22483619_ChIP-Seq_HELA_Human1.59440236
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58367123
48MAF_26560356_Chip-Seq_TH1_Human1.58333468
49GABP_19822575_ChIP-Seq_HepG2_Human1.57613138
50RACK7_27058665_Chip-Seq_MCF-7_Human1.56868803
51VDR_23849224_ChIP-Seq_CD4+_Human1.55253424
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55004230
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53852012
54ZNF263_19887448_ChIP-Seq_K562_Human1.53246715
55TTF2_22483619_ChIP-Seq_HELA_Human1.52361516
56MAF_26560356_Chip-Seq_TH2_Human1.50712479
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49919745
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49606700
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47800466
60TCF7_22412390_ChIP-Seq_EML_Mouse1.46992366
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46367159
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.45348479
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43207770
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42696432
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41792922
66CIITA_25753668_ChIP-Seq_RAJI_Human1.41002894
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40991727
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39717976
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39695934
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38835755
71FOXP3_21729870_ChIP-Seq_TREG_Human1.38609680
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37839868
73* NCOR1_26117541_ChIP-Seq_K562_Human1.37402307
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36088460
75* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34351612
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33871653
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32812040
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32278319
79UTX_26944678_Chip-Seq_JUKART_Human1.31098291
80KDM2B_26808549_Chip-Seq_DND41_Human1.29970340
81* YY1_21170310_ChIP-Seq_MESCs_Mouse1.29500897
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28113388
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27995498
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.27987358
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27625798
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25673172
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24813659
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24351046
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23682972
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22956838
91* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22808217
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22646948
93VDR_24763502_ChIP-Seq_THP-1_Human1.22471444
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21560780
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21507609
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21305355
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21229831
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19936952
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19600940
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19589763
101* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18080550
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17677686
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17474808
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.17288415
105* SPI1_23547873_ChIP-Seq_NB4_Human1.17276553
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.16800652
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16366063
108TFEB_21752829_ChIP-Seq_HELA_Human1.16266286
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16084715
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16030856
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15991090
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15317350
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13267286
114P68_20966046_ChIP-Seq_HELA_Human1.12348520
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.11911870
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10942056
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.09681209
118IRF8_22096565_ChIP-ChIP_GC-B_Human1.09132970
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08704447
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07678041
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07413156
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06634591
123VDR_21846776_ChIP-Seq_THP-1_Human1.06018161
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06001723
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05730384
126* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04925642
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03724351
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03632542
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03630760
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02786589
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02463820
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02040353
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01785422
134* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01771265
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01649596
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01443550
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01172628
138CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00147083
139ATF3_27146783_Chip-Seq_COLON_Human0.99398734
140SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98939468
141* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97290197
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96705473
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96320748
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96294823
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96120947
146POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95842532
147TP63_19390658_ChIP-ChIP_HaCaT_Human0.95140588
148NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94213430
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.93428004
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92410252
151NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91803653
152ELK1_19687146_ChIP-ChIP_HELA_Human0.88854748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.56638072
2MP0004957_abnormal_blastocyst_morpholog4.45007479
3MP0003111_abnormal_nucleus_morphology4.00921701
4MP0010094_abnormal_chromosome_stability3.58533723
5MP0005451_abnormal_body_composition3.47438396
6MP0003077_abnormal_cell_cycle3.37566339
7MP0008057_abnormal_DNA_replication3.15078774
8MP0005058_abnormal_lysosome_morphology3.14755606
9MP0010352_gastrointestinal_tract_polyps3.08613156
10MP0003705_abnormal_hypodermis_morpholog2.94187623
11MP0001730_embryonic_growth_arrest2.79333886
12MP0002877_abnormal_melanocyte_morpholog2.59984867
13MP0003763_abnormal_thymus_physiology2.50979703
14MP0003123_paternal_imprinting2.44982938
15MP0008932_abnormal_embryonic_tissue2.32378375
16MP0000350_abnormal_cell_proliferation2.30814423
17MP0003806_abnormal_nucleotide_metabolis2.29078843
18MP0009333_abnormal_splenocyte_physiolog2.26890119
19MP0001672_abnormal_embryogenesis/_devel2.18023913
20MP0005380_embryogenesis_phenotype2.18023913
21MP0008058_abnormal_DNA_repair2.15950085
22MP0010307_abnormal_tumor_latency2.07865499
23MP0003300_gastrointestinal_ulcer2.05103008
24MP0002084_abnormal_developmental_patter2.02953250
25MP0001697_abnormal_embryo_size2.00639865
26MP0008260_abnormal_autophagy1.98191782
27MP0003984_embryonic_growth_retardation1.96773194
28MP0002088_abnormal_embryonic_growth/wei1.95165870
29MP0002085_abnormal_embryonic_tissue1.94644048
30MP0005076_abnormal_cell_differentiation1.92306090
31MP0002086_abnormal_extraembryonic_tissu1.90970477
32MP0004197_abnormal_fetal_growth/weight/1.90759234
33MP0003436_decreased_susceptibility_to1.89196806
34MP0000537_abnormal_urethra_morphology1.87860118
35MP0002080_prenatal_lethality1.86639996
36MP0008007_abnormal_cellular_replicative1.79823795
37MP0003890_abnormal_embryonic-extraembry1.71521822
38MP0002653_abnormal_ependyma_morphology1.71271998
39MP0004947_skin_inflammation1.69377193
40MP0003119_abnormal_digestive_system1.67129971
41MP0010030_abnormal_orbit_morphology1.63681852
42MP0003172_abnormal_lysosome_physiology1.63266118
43MP0003191_abnormal_cellular_cholesterol1.59987811
44MP0001790_abnormal_immune_system1.59985199
45MP0005387_immune_system_phenotype1.59985199
46MP0000858_altered_metastatic_potential1.58381775
47MP0010234_abnormal_vibrissa_follicle1.54015726
48MP0002398_abnormal_bone_marrow1.53333386
49MP0000703_abnormal_thymus_morphology1.50481241
50MP0003303_peritoneal_inflammation1.49145344
51MP0003567_abnormal_fetal_cardiomyocyte1.45324922
52MP0003786_premature_aging1.45265177
53MP0005025_abnormal_response_to1.41622901
54MP0000490_abnormal_crypts_of1.40298806
55MP0003656_abnormal_erythrocyte_physiolo1.37859030
56MP0001800_abnormal_humoral_immune1.37306484
57MP0001853_heart_inflammation1.37143864
58MP0000685_abnormal_immune_system1.37072879
59MP0005000_abnormal_immune_tolerance1.37033092
60MP0003566_abnormal_cell_adhesion1.36343553
61MP0001873_stomach_inflammation1.36175956
62MP0005083_abnormal_biliary_tract1.34516543
63MP0004133_heterotaxia1.34516490
64MP0000678_abnormal_parathyroid_gland1.34493895
65MP0009053_abnormal_anal_canal1.34376239
66MP0001293_anophthalmia1.32798556
67MP0001849_ear_inflammation1.32760311
68MP0001835_abnormal_antigen_presentation1.29187526
69MP0002420_abnormal_adaptive_immunity1.28849016
70MP0002722_abnormal_immune_system1.27932349
71MP0001819_abnormal_immune_cell1.27012864
72MP0002452_abnormal_antigen_presenting1.26702546
73MP0000313_abnormal_cell_death1.25989916
74MP0003718_maternal_effect1.25087571
75MP0005671_abnormal_response_to1.24979148
76MP0002723_abnormal_immune_serum1.24845737
77MP0005464_abnormal_platelet_physiology1.23937876
78MP0000689_abnormal_spleen_morphology1.21089625
79MP0006036_abnormal_mitochondrial_physio1.20785009
80MP0004264_abnormal_extraembryonic_tissu1.19500839
81MP0002269_muscular_atrophy1.19431900
82MP0004233_abnormal_muscle_weight1.18882175
83MP0002429_abnormal_blood_cell1.18417979
84MP0002396_abnormal_hematopoietic_system1.16155569
85MP0002019_abnormal_tumor_incidence1.15446141
86MP0003283_abnormal_digestive_organ1.14647149
87MP0000358_abnormal_cell_content/1.14479963
88MP0000716_abnormal_immune_system1.14113843
89MP0000003_abnormal_adipose_tissue1.12957850
90MP0002166_altered_tumor_susceptibility1.11396161
91MP0005501_abnormal_skin_physiology1.08888964
92MP0002419_abnormal_innate_immunity1.08308216
93MP0004185_abnormal_adipocyte_glucose1.08220309
94MP0003221_abnormal_cardiomyocyte_apopto1.07931456
95MP0002111_abnormal_tail_morphology1.06260325
96MP0001661_extended_life_span1.06166927
97MP0009785_altered_susceptibility_to1.05556416
98MP0005375_adipose_tissue_phenotype1.04378783
99MP0002796_impaired_skin_barrier1.03663300
100MP0000750_abnormal_muscle_regeneration1.02203900
101MP0004381_abnormal_hair_follicle1.02049457
102MP0010155_abnormal_intestine_physiology1.01634593
103MP0009672_abnormal_birth_weight1.01390358
104MP0005023_abnormal_wound_healing1.00706989
105MP0000428_abnormal_craniofacial_morphol1.00542804
106MP0002132_abnormal_respiratory_system0.99036672
107MP0002148_abnormal_hypersensitivity_rea0.98876968
108MP0002009_preneoplasia0.95808182
109MP0005310_abnormal_salivary_gland0.95251635
110MP0002092_abnormal_eye_morphology0.94374305
111MP0003315_abnormal_perineum_morphology0.94145870
112MP0001145_abnormal_male_reproductive0.91239375
113MP0003941_abnormal_skin_development0.90665403
114MP0009931_abnormal_skin_appearance0.90399206
115MP0008770_decreased_survivor_rate0.88144412
116MP0009703_decreased_birth_body0.87831291
117MP0000759_abnormal_skeletal_muscle0.87636009
118MP0006035_abnormal_mitochondrial_morpho0.87518077
119MP0005666_abnormal_adipose_tissue0.86504638
120MP0003121_genomic_imprinting0.86319929
121MP0000733_abnormal_muscle_development0.85957615
122MP0002697_abnormal_eye_size0.85829437
123MP0002210_abnormal_sex_determination0.84070711
124MP0005266_abnormal_metabolism0.82432490
125MP0009840_abnormal_foam_cell0.80621183
126MP0009278_abnormal_bone_marrow0.80516348
127MP0005384_cellular_phenotype0.76841018
128MP0008877_abnormal_DNA_methylation0.74639580
129MP0000371_diluted_coat_color0.74134918
130MP0000747_muscle_weakness0.73282128
131MP0001915_intracranial_hemorrhage0.72997736
132MP0004084_abnormal_cardiac_muscle0.70334191
133MP0005621_abnormal_cell_physiology0.70206771
134MP0003937_abnormal_limbs/digits/tail_de0.69518782
135MP0000477_abnormal_intestine_morphology0.69518613
136MP0001929_abnormal_gametogenesis0.68655985
137MP0003115_abnormal_respiratory_system0.67711610
138MP0003861_abnormal_nervous_system0.67072637
139MP0003453_abnormal_keratinocyte_physiol0.66872369
140MP0003935_abnormal_craniofacial_develop0.66082187
141MP0010630_abnormal_cardiac_muscle0.65942023
142MP0001727_abnormal_embryo_implantation0.63550749
143MP0002925_abnormal_cardiovascular_devel0.62907416
144MP0001348_abnormal_lacrimal_gland0.62465196
145MP0000653_abnormal_sex_gland0.61204697
146MP0001545_abnormal_hematopoietic_system0.61190354
147MP0005397_hematopoietic_system_phenotyp0.61190354
148MP0000432_abnormal_head_morphology0.59770001
149MP0004808_abnormal_hematopoietic_stem0.59342169
150MP0005623_abnormal_meninges_morphology0.58870807
151MP0000377_abnormal_hair_follicle0.58637547
152MP0001286_abnormal_eye_development0.58350535

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.14912382
2Fatigue (HP:0012378)3.79354136
3Astrocytoma (HP:0009592)3.75900137
4Abnormality of the astrocytes (HP:0100707)3.75900137
5Selective tooth agenesis (HP:0001592)3.71576958
6Multiple enchondromatosis (HP:0005701)3.66085147
7Rhabdomyosarcoma (HP:0002859)3.37003792
8Colon cancer (HP:0003003)3.24018083
9Abnormality of the anterior horn cell (HP:0006802)3.16332197
10Degeneration of anterior horn cells (HP:0002398)3.16332197
11Abnormal gallbladder physiology (HP:0012438)3.12756608
12Cholecystitis (HP:0001082)3.12756608
13Medulloblastoma (HP:0002885)3.07172067
14Trismus (HP:0000211)3.06189828
15Angiofibromas (HP:0010615)3.05616408
16Adenoma sebaceum (HP:0009720)3.05616408
17Progressive external ophthalmoplegia (HP:0000590)3.01996779
18Breast hypoplasia (HP:0003187)3.00843280
19Ragged-red muscle fibers (HP:0003200)2.95352127
20Reticulocytopenia (HP:0001896)2.95302070
21Hypertensive crisis (HP:0100735)2.91688817
22Glioma (HP:0009733)2.89338011
23Abnormality of the lower motor neuron (HP:0002366)2.89265524
24Centrally nucleated skeletal muscle fibers (HP:0003687)2.86555142
25Birth length less than 3rd percentile (HP:0003561)2.85114787
26Neoplasm of striated muscle (HP:0009728)2.83434661
27Microvesicular hepatic steatosis (HP:0001414)2.82549080
28Myopathic facies (HP:0002058)2.79181568
29Reticulocytosis (HP:0001923)2.73578909
30Missing ribs (HP:0000921)2.70629832
31Oral leukoplakia (HP:0002745)2.68717991
32Basal cell carcinoma (HP:0002671)2.67201394
33Aplasia/hypoplasia of the humerus (HP:0006507)2.66512444
34Impulsivity (HP:0100710)2.59592031
35Abnormality of the labia minora (HP:0012880)2.58931649
36Abnormality of cells of the erythroid lineage (HP:0012130)2.55222593
37Absent radius (HP:0003974)2.54735009
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.48331014
39Exercise-induced myalgia (HP:0003738)2.47863522
40Short humerus (HP:0005792)2.47507297
41Biliary tract neoplasm (HP:0100574)2.47506300
42Absent thumb (HP:0009777)2.46477391
43Sparse lateral eyebrow (HP:0005338)2.43701359
44Progressive muscle weakness (HP:0003323)2.42574857
45Patellar aplasia (HP:0006443)2.41645556
46Neoplasm of the pancreas (HP:0002894)2.39109692
47Carpal bone hypoplasia (HP:0001498)2.38962004
48Hyperacusis (HP:0010780)2.35827825
49Aplasia involving forearm bones (HP:0009822)2.35081158
50Absent forearm bone (HP:0003953)2.35081158
51Abnormality of reticulocytes (HP:0004312)2.34942357
52Seborrheic dermatitis (HP:0001051)2.34427400
53Deep palmar crease (HP:0006191)2.33086979
54Rib fusion (HP:0000902)2.30748558
55Agnosia (HP:0010524)2.30703429
56Rough bone trabeculation (HP:0100670)2.30079491
57Aplasia/Hypoplasia of the patella (HP:0006498)2.28280478
58Insomnia (HP:0100785)2.27701799
59Recurrent viral infections (HP:0004429)2.27223439
60Colitis (HP:0002583)2.26643227
61Rhabdomyolysis (HP:0003201)2.26187300
62Proximal placement of thumb (HP:0009623)2.25679465
63Neoplasm of the oral cavity (HP:0100649)2.23331675
64Spastic diplegia (HP:0001264)2.22891743
65Eczematoid dermatitis (HP:0000976)2.20527198
66Squamous cell carcinoma (HP:0002860)2.20301022
67Distal lower limb amyotrophy (HP:0008944)2.18689859
68Deviation of the thumb (HP:0009603)2.18327678
69Abnormal number of erythroid precursors (HP:0012131)2.17633695
70Hand muscle atrophy (HP:0009130)2.16389056
71Abnormality of the salivary glands (HP:0010286)2.15110820
72Gastrointestinal stroma tumor (HP:0100723)2.12988407
73Cholelithiasis (HP:0001081)2.12528685
74Difficulty climbing stairs (HP:0003551)2.11739120
75Muscle fibrillation (HP:0010546)2.10992938
76Abnormality of macrophages (HP:0004311)2.09021329
77Increased serum ferritin (HP:0003281)2.07919013
78Cellulitis (HP:0100658)2.07696574
79Aplasia/Hypoplasia of the thymus (HP:0010515)2.06835336
80Pelvic girdle muscle weakness (HP:0003749)2.05391814
81Tongue fasciculations (HP:0001308)2.04711484
82Entropion (HP:0000621)2.03689212
83Abnormal number of incisors (HP:0011064)2.02393886
84Hypoparathyroidism (HP:0000829)2.02105353
85Spinal muscular atrophy (HP:0007269)2.01881565
86Pseudobulbar signs (HP:0002200)2.01289874
87Achilles tendon contracture (HP:0001771)2.00955223
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00385270
89Poikiloderma (HP:0001029)1.99662040
90Distal lower limb muscle weakness (HP:0009053)1.99071593
91Atresia of the external auditory canal (HP:0000413)1.98034601
92Recurrent bacterial skin infections (HP:0005406)1.97597109
93Abnormality of abdominal situs (HP:0011620)1.97445466
94Abdominal situs inversus (HP:0003363)1.97445466
95Broad face (HP:0000283)1.96674783
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96437959
97Cafe-au-lait spot (HP:0000957)1.95888013
98Glossoptosis (HP:0000162)1.94283763
99Gastrointestinal carcinoma (HP:0002672)1.93369280
100Malignant gastrointestinal tract tumors (HP:0006749)1.93369280
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93122022
102Insidious onset (HP:0003587)1.92691527
103Termporal pattern (HP:0011008)1.92691527
104Recurrent abscess formation (HP:0002722)1.92253975
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91739558
106Abnormality of the motor neurons (HP:0002450)1.91683337
107Abnormal neuron morphology (HP:0012757)1.91683337
108Diastasis recti (HP:0001540)1.91388235
109Flat acetabular roof (HP:0003180)1.90949898
110Hyperparathyroidism (HP:0000843)1.90201554
111Abnormality of the ileum (HP:0001549)1.89248730
112Agammaglobulinemia (HP:0004432)1.88736272
113Amyotrophic lateral sclerosis (HP:0007354)1.88524158
114Athetosis (HP:0002305)1.88472632
115Abnormality of the calcaneus (HP:0008364)1.87301467
116Hepatitis (HP:0012115)1.87255301
117Hyperthyroidism (HP:0000836)1.86440976
118Shawl scrotum (HP:0000049)1.85277862
119Gastrointestinal inflammation (HP:0004386)1.85270104
120Shoulder girdle muscle weakness (HP:0003547)1.85225206
121Abnormality of the thoracic spine (HP:0100711)1.85194718
122Fibroma (HP:0010614)1.85107648
123Hepatosplenomegaly (HP:0001433)1.84602199
124Metaphyseal cupping (HP:0003021)1.84594889
125Abnormality of the Achilles tendon (HP:0005109)1.84592578
126Neuronal loss in central nervous system (HP:0002529)1.84515247
127Meckel diverticulum (HP:0002245)1.84219281
128Chromsome breakage (HP:0040012)1.84136317
129Facial hemangioma (HP:0000329)1.83695473
130Distal upper limb amyotrophy (HP:0007149)1.83548510
131Upper limb amyotrophy (HP:0009129)1.83548510
132Macrocytic anemia (HP:0001972)1.83130627
133Increased nuchal translucency (HP:0010880)1.83084200
134Supernumerary spleens (HP:0009799)1.82819419
135Prominent nose (HP:0000448)1.82233891
136Vertebral compression fractures (HP:0002953)1.81740989
137Slow saccadic eye movements (HP:0000514)1.80971265
138Orthostatic hypotension (HP:0001278)1.80625132
139Ovarian neoplasm (HP:0100615)1.79483187
140Abnormality of pyrimidine metabolism (HP:0004353)1.78589438
141Ankle contracture (HP:0006466)1.78582321
142Rectal fistula (HP:0100590)1.78411980
143Rectovaginal fistula (HP:0000143)1.78411980
144Chronic obstructive pulmonary disease (HP:0006510)1.78293663
145Obstructive lung disease (HP:0006536)1.78293663
146Intestinal polyp (HP:0005266)1.77454011
147Microretrognathia (HP:0000308)1.77447323
148Preauricular skin tag (HP:0000384)1.76560539
149Pallor (HP:0000980)1.75850607
150Intestinal polyposis (HP:0200008)1.74644648
151Abnormal gallbladder morphology (HP:0012437)1.74360520
152Abnormal cartilage morphology (HP:0002763)1.73997106
153Testicular atrophy (HP:0000029)1.73867246
154Horseshoe kidney (HP:0000085)1.72456802
155Increased connective tissue (HP:0009025)1.72113302
156Fibrous tissue neoplasm (HP:0012316)1.72046019
157Abnormality of the gallbladder (HP:0005264)1.71680714
158Increased IgE level (HP:0003212)1.71230797
159Abnormality of the fingertips (HP:0001211)1.70989423
160Back pain (HP:0003418)1.70891279
161Diaphragmatic weakness (HP:0009113)1.70479250
162Thrombocytosis (HP:0001894)1.69242627
163Biconcave vertebral bodies (HP:0004586)1.69168626
164Ankyloglossia (HP:0010296)1.68294766
165Abnormality of the tricuspid valve (HP:0001702)1.67749944
166Long palpebral fissure (HP:0000637)1.67010884
167Mediastinal lymphadenopathy (HP:0100721)1.65934329
168Increased muscle lipid content (HP:0009058)1.64713287
169Lymphopenia (HP:0001888)1.64186615
170Truncus arteriosus (HP:0001660)1.63200255
171Meningitis (HP:0001287)1.63062369
172Abnormality of small intestinal villus morphology (HP:0011472)1.62261824
173Villous atrophy (HP:0011473)1.62261824
174Muscle stiffness (HP:0003552)1.61341431
175Upper motor neuron abnormality (HP:0002127)1.60468061
176Progressive neurologic deterioration (HP:0002344)1.59814497
177Acute hepatic failure (HP:0006554)1.58667128
178Impaired proprioception (HP:0010831)1.58450990
179Abnormal large intestine physiology (HP:0012700)1.57795100
180Thoracic kyphosis (HP:0002942)1.57719014
181Bowel incontinence (HP:0002607)1.57485078
182Broad distal phalanx of finger (HP:0009836)1.57360517
183Abnormality of liposaccharide metabolism (HP:0010968)1.56776786
184Abnormality of glycosphingolipid metabolism (HP:0004343)1.56776786
185Abnormality of glycolipid metabolism (HP:0010969)1.56776786
186Bone pain (HP:0002653)1.56773815
187Abnormality of glycolysis (HP:0004366)1.56250745
188Increased intramyocellular lipid droplets (HP:0012240)1.55493793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.65912223
2WEE13.47065169
3CDC73.04579502
4CDK123.03888805
5SMG12.97858129
6EPHA22.96854999
7NEK12.87766553
8PRPF4B2.79218411
9NEK22.73041501
10IRAK32.59247089
11EEF2K2.48733974
12TTK2.37732980
13PKN22.21296075
14TLK12.21085976
15TRIB32.14308300
16RPS6KB22.10288574
17MAP3K102.06204070
18MAP4K11.91157696
19TSSK61.83873919
20EIF2AK11.83276407
21FGFR41.81972882
22PLK11.75107505
23SCYL21.74455548
24PASK1.73891002
25RIPK41.72158442
26CDK71.67395610
27NME21.60866898
28SRPK11.60267596
29STK161.53801209
30DYRK31.53249448
31PAK41.49170490
32MAP3K131.46975497
33CDK41.45631859
34PDK41.44559500
35PDK31.44559500
36ACVR1B1.41681326
37MAP3K81.41587386
38TESK21.38079579
39AURKB1.37802181
40CHEK21.35107377
41ALK1.34082813
42LATS21.33468064
43SIK11.32293849
44MARK31.31679785
45AURKA1.30399291
46PIM21.28595689
47ICK1.27075441
48ATR1.25051548
49STK101.24869199
50FLT31.24565438
51CHEK11.21038405
52TTN1.20782514
53TAOK21.17186331
54RIPK11.12884741
55MAPKAPK31.10298283
56MAP3K141.06672547
57MTOR1.06309274
58PDGFRA1.02655074
59LRRK21.02490118
60MAP3K11.00169290
61BCKDK0.99897662
62JAK30.99148740
63TYK20.95432201
64PLK30.94322890
65TGFBR10.93170467
66KSR20.92708216
67* CDK20.89459669
68TBK10.88628298
69BRSK20.87445354
70TYRO30.87164228
71PNCK0.86507730
72CLK10.85500367
73RPS6KA40.85438456
74CCNB10.85384655
75GRK60.85296733
76DDR20.84893709
77PRKCI0.83979388
78BLK0.83150008
79SIK30.82436389
80RAF10.81888022
81MAP3K110.80653115
82PTK60.75536908
83MST1R0.75299961
84BMX0.75042328
85PAK10.72368612
86ATM0.72219686
87PDK20.71418603
88PIM10.71219530
89AKT20.70481800
90PDPK10.70142475
91MARK20.68284555
92ZAP700.68121825
93CDK60.65959228
94EIF2AK30.63837926
95TESK10.63604481
96BRSK10.62046226
97* CSNK2A20.60926464
98* CSNK1E0.60856215
99IRAK20.60485127
100PAK20.59951743
101MAP2K60.58748523
102SIK20.58498336
103IKBKE0.57473422
104FGFR10.56282123
105MELK0.56277206
106CDK10.55210958
107MKNK10.53736272
108ARAF0.53046624
109MAPK120.52162987
110BRAF0.51106337
111TAOK10.50957536
112MAP2K30.50291415
113IRAK40.50077433
114ILK0.49158148
115JAK20.49104761
116RPS6KL10.47964384
117RPS6KC10.47964384
118FGFR30.47483605
119STK40.46534858
120MAP2K20.46216474
121VRK10.45803688
122STK30.44921855
123AKT30.44274084
124PDK10.44259695
125MET0.44167328
126* CSNK2A10.41365852
127DAPK10.40546370
128BTK0.40025004
129MATK0.38407807
130CDC42BPA0.37960256
131KDR0.37114084
132RPS6KB10.36989676
133IKBKB0.35450089
134ZAK0.35367686
135CSNK1D0.35170462
136RPS6KA10.34911197
137RET0.34419301
138PRKDC0.34205821
139PTK20.34198005
140FGR0.33384751
141PLK40.32968367
142STK38L0.32148359
143DYRK1B0.32135062
144BRD40.30533243
145MAPK110.28014521
146MAP3K30.27652124
147ERN10.27157266
148LATS10.26903926
149NME10.25449846

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.13428712
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77107199
3Mismatch repair_Homo sapiens_hsa034303.70200402
4* RNA transport_Homo sapiens_hsa030133.35003587
5Other glycan degradation_Homo sapiens_hsa005113.25600767
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03755150
7One carbon pool by folate_Homo sapiens_hsa006703.03585855
8Spliceosome_Homo sapiens_hsa030402.97244059
9Ribosome_Homo sapiens_hsa030102.86552698
10Base excision repair_Homo sapiens_hsa034102.46531501
11Proteasome_Homo sapiens_hsa030502.45687408
12Nucleotide excision repair_Homo sapiens_hsa034202.38030225
13Cell cycle_Homo sapiens_hsa041102.34214631
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33907770
15RNA polymerase_Homo sapiens_hsa030202.32050525
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.08409131
17mRNA surveillance pathway_Homo sapiens_hsa030151.96543464
18Homologous recombination_Homo sapiens_hsa034401.94192632
19B cell receptor signaling pathway_Homo sapiens_hsa046621.90879417
20Biosynthesis of amino acids_Homo sapiens_hsa012301.81594928
21Pyrimidine metabolism_Homo sapiens_hsa002401.78581787
22Fanconi anemia pathway_Homo sapiens_hsa034601.56900532
23Pancreatic cancer_Homo sapiens_hsa052121.52982626
24Vitamin B6 metabolism_Homo sapiens_hsa007501.49035915
25p53 signaling pathway_Homo sapiens_hsa041151.48588469
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.48327693
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47769025
28Selenocompound metabolism_Homo sapiens_hsa004501.47538521
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46683924
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45818245
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37270569
32Carbon metabolism_Homo sapiens_hsa012001.35931940
33Systemic lupus erythematosus_Homo sapiens_hsa053221.34452335
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.29670459
35Sulfur relay system_Homo sapiens_hsa041221.29134648
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.26444525
37Primary immunodeficiency_Homo sapiens_hsa053401.23963520
38RNA degradation_Homo sapiens_hsa030181.22478325
39Pentose phosphate pathway_Homo sapiens_hsa000301.20241916
40Folate biosynthesis_Homo sapiens_hsa007901.19607358
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18775565
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18014911
43Measles_Homo sapiens_hsa051621.14861765
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14617419
45Hepatitis B_Homo sapiens_hsa051611.14381073
46Non-homologous end-joining_Homo sapiens_hsa034501.11287556
47Basal transcription factors_Homo sapiens_hsa030221.08689667
48Viral carcinogenesis_Homo sapiens_hsa052031.08612664
49Osteoclast differentiation_Homo sapiens_hsa043801.08082389
50Oocyte meiosis_Homo sapiens_hsa041141.02777900
51T cell receptor signaling pathway_Homo sapiens_hsa046601.02564163
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99867194
53Fructose and mannose metabolism_Homo sapiens_hsa000510.99753608
54Influenza A_Homo sapiens_hsa051640.99136124
55Hepatitis C_Homo sapiens_hsa051600.98912806
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98284720
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98203957
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97140225
59Epstein-Barr virus infection_Homo sapiens_hsa051690.95968923
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95843116
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95056862
62Hippo signaling pathway_Homo sapiens_hsa043900.93288581
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91211808
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90948976
65mTOR signaling pathway_Homo sapiens_hsa041500.90436149
66Thyroid cancer_Homo sapiens_hsa052160.89835391
67Shigellosis_Homo sapiens_hsa051310.88583217
68Renal cell carcinoma_Homo sapiens_hsa052110.88442777
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.87860856
70Bladder cancer_Homo sapiens_hsa052190.87820450
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87070434
72TNF signaling pathway_Homo sapiens_hsa046680.86092806
73Leishmaniasis_Homo sapiens_hsa051400.85854157
74Prion diseases_Homo sapiens_hsa050200.82042999
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81770651
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.81703583
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80830559
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79865241
79Lysosome_Homo sapiens_hsa041420.79325510
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77300418
81ErbB signaling pathway_Homo sapiens_hsa040120.76628967
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.76056506
83MicroRNAs in cancer_Homo sapiens_hsa052060.75859831
84Inositol phosphate metabolism_Homo sapiens_hsa005620.74147960
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.72907077
86Basal cell carcinoma_Homo sapiens_hsa052170.72752276
87Prostate cancer_Homo sapiens_hsa052150.72048789
88Glioma_Homo sapiens_hsa052140.70979992
89Vibrio cholerae infection_Homo sapiens_hsa051100.70282322
90Small cell lung cancer_Homo sapiens_hsa052220.69056511
91HTLV-I infection_Homo sapiens_hsa051660.68668884
92Purine metabolism_Homo sapiens_hsa002300.68406747
93Toxoplasmosis_Homo sapiens_hsa051450.67373477
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.66300616
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64804557
96Antigen processing and presentation_Homo sapiens_hsa046120.64713295
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63348570
98Salmonella infection_Homo sapiens_hsa051320.62172149
99Galactose metabolism_Homo sapiens_hsa000520.62068402
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59228497
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58626526
102Insulin resistance_Homo sapiens_hsa049310.58132257
103Prolactin signaling pathway_Homo sapiens_hsa049170.57401476
104Pyruvate metabolism_Homo sapiens_hsa006200.54647104
105Lysine degradation_Homo sapiens_hsa003100.54504802
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54162150
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53912691
108Endocytosis_Homo sapiens_hsa041440.53589540
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52927121
110Tuberculosis_Homo sapiens_hsa051520.52306410
111Adherens junction_Homo sapiens_hsa045200.51376926
112Tight junction_Homo sapiens_hsa045300.51065813
113Hedgehog signaling pathway_Homo sapiens_hsa043400.50686668
114Arginine and proline metabolism_Homo sapiens_hsa003300.49442461
115Notch signaling pathway_Homo sapiens_hsa043300.48022395
116Glutathione metabolism_Homo sapiens_hsa004800.46538077
117AMPK signaling pathway_Homo sapiens_hsa041520.46126376
118Alcoholism_Homo sapiens_hsa050340.44864391
119Herpes simplex infection_Homo sapiens_hsa051680.44234855
120Chronic myeloid leukemia_Homo sapiens_hsa052200.43234823
121Arginine biosynthesis_Homo sapiens_hsa002200.42226128
122Colorectal cancer_Homo sapiens_hsa052100.41457341
123HIF-1 signaling pathway_Homo sapiens_hsa040660.39520962
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38711886
125TGF-beta signaling pathway_Homo sapiens_hsa043500.38103047
126Fat digestion and absorption_Homo sapiens_hsa049750.36325596
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34774112
128Proteoglycans in cancer_Homo sapiens_hsa052050.34138600
129Legionellosis_Homo sapiens_hsa051340.33584996
130Apoptosis_Homo sapiens_hsa042100.30860270
131Nitrogen metabolism_Homo sapiens_hsa009100.30244191
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28808522
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28407128
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27324121
135Insulin signaling pathway_Homo sapiens_hsa049100.26794721
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25583398
137Pathways in cancer_Homo sapiens_hsa052000.25462562
138Viral myocarditis_Homo sapiens_hsa054160.22145944
139Non-small cell lung cancer_Homo sapiens_hsa052230.21886308
140Endometrial cancer_Homo sapiens_hsa052130.21172791
141Acute myeloid leukemia_Homo sapiens_hsa052210.20648253
142Fatty acid biosynthesis_Homo sapiens_hsa000610.20622198
143Glucagon signaling pathway_Homo sapiens_hsa049220.16706326
144VEGF signaling pathway_Homo sapiens_hsa043700.15826605
145Metabolic pathways_Homo sapiens_hsa011000.15160762
146N-Glycan biosynthesis_Homo sapiens_hsa005100.14850435
147Wnt signaling pathway_Homo sapiens_hsa043100.13122024

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