EIF2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.06857170
2purine nucleobase biosynthetic process (GO:0009113)4.99415781
3DNA strand elongation involved in DNA replication (GO:0006271)4.74105397
4DNA replication initiation (GO:0006270)4.71376738
5* formation of translation preinitiation complex (GO:0001731)4.55513023
6DNA strand elongation (GO:0022616)4.53144787
7IMP biosynthetic process (GO:0006188)4.45635589
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35822692
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31980952
10DNA unwinding involved in DNA replication (GO:0006268)4.27735329
11folic acid-containing compound biosynthetic process (GO:0009396)4.23219702
12protein targeting to ER (GO:0045047)4.23019016
13telomere maintenance via semi-conservative replication (GO:0032201)4.22940528
14cotranslational protein targeting to membrane (GO:0006613)4.21652685
15mitotic metaphase plate congression (GO:0007080)4.17527346
16DNA replication checkpoint (GO:0000076)4.07665782
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06635113
18viral life cycle (GO:0019058)3.99834414
19ribosome assembly (GO:0042255)3.96141518
20protein localization to endoplasmic reticulum (GO:0070972)3.94356262
21IMP metabolic process (GO:0046040)3.92350639
22ribosome biogenesis (GO:0042254)3.91498897
23ribosomal small subunit assembly (GO:0000028)3.90067191
24folic acid metabolic process (GO:0046655)3.88677654
25cellular protein complex disassembly (GO:0043624)3.88165011
26regulation of histone H3-K27 methylation (GO:0061085)3.86757524
27regulation of translational fidelity (GO:0006450)3.85529256
28maturation of SSU-rRNA (GO:0030490)3.85265348
29mitotic nuclear envelope disassembly (GO:0007077)3.78626305
30telomere maintenance via recombination (GO:0000722)3.74284810
31metaphase plate congression (GO:0051310)3.68054373
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65849491
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.65849491
34protein localization to kinetochore (GO:0034501)3.60004726
35DNA replication-dependent nucleosome assembly (GO:0006335)3.59131967
36DNA replication-dependent nucleosome organization (GO:0034723)3.59131967
37mitotic recombination (GO:0006312)3.54581745
38nuclear pore organization (GO:0006999)3.52063291
39protein complex disassembly (GO:0043241)3.51867138
40ribonucleoprotein complex biogenesis (GO:0022613)3.51720382
41DNA deamination (GO:0045006)3.51636306
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46815969
43membrane disassembly (GO:0030397)3.45671516
44nuclear envelope disassembly (GO:0051081)3.45671516
45CENP-A containing nucleosome assembly (GO:0034080)3.44935548
46telomere maintenance via telomere lengthening (GO:0010833)3.44921186
47chromatin remodeling at centromere (GO:0031055)3.42509413
48proline biosynthetic process (GO:0006561)3.40549173
49proteasome assembly (GO:0043248)3.39231009
50regulation of posttranscriptional gene silencing (GO:0060147)3.36838998
51regulation of gene silencing by miRNA (GO:0060964)3.36838998
52regulation of gene silencing by RNA (GO:0060966)3.36838998
53ribosomal large subunit biogenesis (GO:0042273)3.33986495
54* macromolecular complex disassembly (GO:0032984)3.30985615
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27737710
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.27600645
57regulation of spindle organization (GO:0090224)3.27017635
58spliceosomal snRNP assembly (GO:0000387)3.26072253
59establishment of chromosome localization (GO:0051303)3.25102186
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24704684
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19772992
62transcription-coupled nucleotide-excision repair (GO:0006283)3.18188535
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17379613
64rRNA modification (GO:0000154)3.16256249
65rRNA processing (GO:0006364)3.15200124
66translation (GO:0006412)3.13459215
67DNA replication-independent nucleosome organization (GO:0034724)3.09132211
68DNA replication-independent nucleosome assembly (GO:0006336)3.09132211
69protein localization to chromosome, centromeric region (GO:0071459)3.09036160
70pseudouridine synthesis (GO:0001522)3.07855466
71viral transcription (GO:0019083)3.04078347
72rRNA metabolic process (GO:0016072)3.04058576
73nuclear-transcribed mRNA catabolic process (GO:0000956)3.03957132
74G1/S transition of mitotic cell cycle (GO:0000082)3.03909255
75cell cycle G1/S phase transition (GO:0044843)3.03909255
76* translational initiation (GO:0006413)3.03618274
77translational termination (GO:0006415)3.03529899
78glycine metabolic process (GO:0006544)3.01539898
79nuclear pore complex assembly (GO:0051292)3.01431034
80translational elongation (GO:0006414)2.99920682
81protein targeting to membrane (GO:0006612)2.99344999
82mRNA catabolic process (GO:0006402)2.98621927
83positive regulation of granulocyte differentiation (GO:0030854)2.95382661
84DNA duplex unwinding (GO:0032508)2.95073797
85negative regulation of chromosome segregation (GO:0051985)2.94831279
86attachment of spindle microtubules to kinetochore (GO:0008608)2.94442032
87DNA geometric change (GO:0032392)2.93891012
88negative regulation of ligase activity (GO:0051352)2.93074884
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93074884
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.91856393
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91856393
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91856393
93negative regulation of sister chromatid segregation (GO:0033046)2.91856393
94ribosomal small subunit biogenesis (GO:0042274)2.90065917
95mismatch repair (GO:0006298)2.89418830
96tRNA aminoacylation for protein translation (GO:0006418)2.88306894
97kinetochore organization (GO:0051383)2.88084403
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86994720
99histone exchange (GO:0043486)2.85701956
100tetrahydrofolate metabolic process (GO:0046653)2.85558658
101oxidative phosphorylation (GO:0006119)2.85317542
102mitotic chromosome condensation (GO:0007076)2.85072595
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84419306
104termination of RNA polymerase I transcription (GO:0006363)2.84363601
105mitotic spindle assembly checkpoint (GO:0007094)2.83808196
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83414559
107pteridine-containing compound biosynthetic process (GO:0042559)2.83140159
108mitotic sister chromatid segregation (GO:0000070)2.82992690
109L-serine metabolic process (GO:0006563)2.82489594
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82247386
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81355258
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.81355258
113amino acid activation (GO:0043038)2.81214534
114tRNA aminoacylation (GO:0043039)2.81214534
115regulation of helicase activity (GO:0051095)2.81181965
116spindle assembly checkpoint (GO:0071173)2.80920457
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80855512
118signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80855512
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80770411
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80770411
121RNA catabolic process (GO:0006401)2.78543860
122negative regulation of erythrocyte differentiation (GO:0045647)2.73549804
123sister chromatid segregation (GO:0000819)2.71879985
124positive regulation of B cell differentiation (GO:0045579)2.67696176
125protoporphyrinogen IX metabolic process (GO:0046501)2.63641789
126rRNA transcription (GO:0009303)2.62580567
127GMP metabolic process (GO:0046037)2.61226643
128pore complex assembly (GO:0046931)2.58755453
129pinocytosis (GO:0006907)2.57731446
130AMP metabolic process (GO:0046033)2.55699900
131cellular component biogenesis (GO:0044085)2.54008097
132Peyers patch development (GO:0048541)2.51780681
133mucosal-associated lymphoid tissue development (GO:0048537)2.51780681
134tricarboxylic acid cycle (GO:0006099)2.47181037
135nucleobase-containing small molecule interconversion (GO:0015949)2.47180631
136regulation of gamma-delta T cell differentiation (GO:0045586)2.46279283
137Golgi transport vesicle coating (GO:0048200)2.45692506
138COPI coating of Golgi vesicle (GO:0048205)2.45692506
139folic acid-containing compound metabolic process (GO:0006760)2.44560092
140definitive hemopoiesis (GO:0060216)2.43777073
141T cell apoptotic process (GO:0070231)2.40632678
142deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.37521262
143pentose-phosphate shunt (GO:0006098)2.34463040
144GDP-mannose metabolic process (GO:0019673)2.31359416
145oxaloacetate metabolic process (GO:0006107)2.31229951
146protoporphyrinogen IX biosynthetic process (GO:0006782)2.30322320
147mitochondrial RNA metabolic process (GO:0000959)2.30142163
148myeloid cell homeostasis (GO:0002262)2.30135310
149mitochondrial DNA metabolic process (GO:0032042)2.28563360
150purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.27601159
151nuclear envelope organization (GO:0006998)2.26736858
152mannose metabolic process (GO:0006013)2.26352637
153snRNA metabolic process (GO:0016073)2.25480089
154regulation of histone H3-K4 methylation (GO:0051569)2.24287364
155positive regulation of gamma-delta T cell activation (GO:0046645)2.24074704
156regulation of RNA export from nucleus (GO:0046831)2.24020316
157pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.23400774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.47563105
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17589109
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68523700
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.16031006
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03564865
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02258329
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98187493
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87600471
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.85937815
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83801481
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82476833
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.74102725
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72104541
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.65306881
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51649924
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39138562
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33698325
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29438096
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22963601
20XRN2_22483619_ChIP-Seq_HELA_Human2.21686218
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14900857
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11048673
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06831052
24VDR_23849224_ChIP-Seq_CD4+_Human2.04590910
25AR_21909140_ChIP-Seq_LNCAP_Human1.93179529
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90689680
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88344641
28DCP1A_22483619_ChIP-Seq_HELA_Human1.88126025
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87003825
30FOXP3_21729870_ChIP-Seq_TREG_Human1.85632506
31VDR_21846776_ChIP-Seq_THP-1_Human1.84954694
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83789474
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83282933
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82607912
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81856169
36GABP_19822575_ChIP-Seq_HepG2_Human1.80539119
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.73683023
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.69967755
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65962823
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64404515
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62258690
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62015376
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61482440
44* CIITA_25753668_ChIP-Seq_RAJI_Human1.59757652
45TTF2_22483619_ChIP-Seq_HELA_Human1.57988094
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57819745
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.54875228
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53970101
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53367291
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52600642
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52026476
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52002161
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.51829786
54MAF_26560356_Chip-Seq_TH1_Human1.49504813
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49164673
56MYC_22102868_ChIP-Seq_BL_Human1.43712205
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43584948
58KDM5A_27292631_Chip-Seq_BREAST_Human1.41935873
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41809028
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40949170
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36288039
62MAF_26560356_Chip-Seq_TH2_Human1.36267749
63ELK1_19687146_ChIP-ChIP_HELA_Human1.28677741
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27569321
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27550554
66MYB_26560356_Chip-Seq_TH1_Human1.26887327
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26319386
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26282648
69NCOR1_26117541_ChIP-Seq_K562_Human1.25828697
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24745083
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23223628
72ZNF263_19887448_ChIP-Seq_K562_Human1.23176758
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.22744646
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21678435
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20826281
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19482091
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18514360
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18412012
79TFEB_21752829_ChIP-Seq_HELA_Human1.18164628
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17865319
81UTX_26944678_Chip-Seq_JUKART_Human1.17279214
82MYB_26560356_Chip-Seq_TH2_Human1.17124751
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15932694
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15576200
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15506443
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15354991
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15354991
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15354991
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13343256
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12955295
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11387939
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08914432
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08116637
94SPI1_23547873_ChIP-Seq_NB4_Human1.07945662
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07279988
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05116615
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04941724
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.04369689
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04358921
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03919061
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03048633
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01894842
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.01389348
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00794102
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00475852
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98221599
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97724758
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97054185
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96631106
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96470977
111GATA1_22025678_ChIP-Seq_K562_Human0.96200881
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96053907
113CHD1_26751641_Chip-Seq_LNCaP_Human0.95934300
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95741637
115RACK7_27058665_Chip-Seq_MCF-7_Human0.95404288
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95318385
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93940135
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92465806
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92100255
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90911734
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90833541
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.89945178
123TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86767920
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85910030
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85526141
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82864687
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82236591
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80807648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.60034202
2MP0004957_abnormal_blastocyst_morpholog4.59864731
3MP0010094_abnormal_chromosome_stability4.37892182
4MP0003111_abnormal_nucleus_morphology4.35561984
5MP0003077_abnormal_cell_cycle3.84252497
6MP0003806_abnormal_nucleotide_metabolis3.76232580
7MP0005451_abnormal_body_composition3.31945839
8MP0008058_abnormal_DNA_repair3.28810863
9MP0008057_abnormal_DNA_replication3.16875623
10MP0008007_abnormal_cellular_replicative2.74787248
11MP0008932_abnormal_embryonic_tissue2.58129922
12MP0010352_gastrointestinal_tract_polyps2.50602064
13MP0001730_embryonic_growth_arrest2.46940247
14MP0001661_extended_life_span2.29447302
15MP0003123_paternal_imprinting2.23971772
16MP0000350_abnormal_cell_proliferation2.19056448
17MP0003718_maternal_effect2.00053798
18MP0003786_premature_aging1.97897926
19MP0002396_abnormal_hematopoietic_system1.89720227
20MP0005380_embryogenesis_phenotype1.87535637
21MP0001672_abnormal_embryogenesis/_devel1.87535637
22MP0001697_abnormal_embryo_size1.80923538
23MP0010307_abnormal_tumor_latency1.74449150
24MP0003984_embryonic_growth_retardation1.72054357
25MP0002088_abnormal_embryonic_growth/wei1.68240571
26MP0002080_prenatal_lethality1.67150098
27MP0004185_abnormal_adipocyte_glucose1.66368410
28MP0002166_altered_tumor_susceptibility1.63959398
29MP0008877_abnormal_DNA_methylation1.61489265
30MP0003186_abnormal_redox_activity1.60760673
31MP0004133_heterotaxia1.51950667
32MP0002086_abnormal_extraembryonic_tissu1.49449436
33MP0000490_abnormal_crypts_of1.48859144
34MP0002085_abnormal_embryonic_tissue1.48169641
35MP0001835_abnormal_antigen_presentation1.47341121
36MP0000313_abnormal_cell_death1.45971267
37MP0000685_abnormal_immune_system1.42439229
38MP0002019_abnormal_tumor_incidence1.41790834
39MP0003656_abnormal_erythrocyte_physiolo1.41586451
40MP0009840_abnormal_foam_cell1.40020752
41MP0000372_irregular_coat_pigmentation1.38006624
42MP0001873_stomach_inflammation1.35649211
43MP0002084_abnormal_developmental_patter1.35630366
44MP0008995_early_reproductive_senescence1.35151845
45MP0003567_abnormal_fetal_cardiomyocyte1.34386477
46MP0004197_abnormal_fetal_growth/weight/1.32729531
47MP0005408_hypopigmentation1.29093223
48MP0010030_abnormal_orbit_morphology1.25383278
49MP0000003_abnormal_adipose_tissue1.24948561
50MP0009333_abnormal_splenocyte_physiolog1.16192830
51MP0000358_abnormal_cell_content/1.15647401
52MP0004808_abnormal_hematopoietic_stem1.15431086
53MP0004264_abnormal_extraembryonic_tissu1.13799806
54MP0000678_abnormal_parathyroid_gland1.12019178
55MP0003890_abnormal_embryonic-extraembry1.10517191
56MP0001800_abnormal_humoral_immune1.08475889
57MP0006036_abnormal_mitochondrial_physio1.07668093
58MP0003119_abnormal_digestive_system1.07415816
59MP0000716_abnormal_immune_system1.06132116
60MP0005023_abnormal_wound_healing1.05045837
61MP0001545_abnormal_hematopoietic_system1.02678530
62MP0005397_hematopoietic_system_phenotyp1.02678530
63MP0005266_abnormal_metabolism1.02174272
64MP0009672_abnormal_birth_weight1.01966804
65MP0002210_abnormal_sex_determination1.01692122
66MP0001293_anophthalmia1.01229167
67MP0009379_abnormal_foot_pigmentation1.00324039
68MP0002006_tumorigenesis0.99116862
69MP0008961_abnormal_basal_metabolism0.98750434
70MP0005671_abnormal_response_to0.97092565
71MP0002420_abnormal_adaptive_immunity0.96378062
72MP0001145_abnormal_male_reproductive0.96214521
73MP0001764_abnormal_homeostasis0.95886557
74MP0001819_abnormal_immune_cell0.95084451
75MP0003221_abnormal_cardiomyocyte_apopto0.92780580
76MP0006292_abnormal_olfactory_placode0.91990362
77MP0005375_adipose_tissue_phenotype0.91932506
78MP0003121_genomic_imprinting0.91720967
79MP0002009_preneoplasia0.90891294
80MP0006035_abnormal_mitochondrial_morpho0.90696341
81MP0003763_abnormal_thymus_physiology0.90165241
82MP0005384_cellular_phenotype0.88996553
83MP0001853_heart_inflammation0.88377346
84MP0008260_abnormal_autophagy0.87702183
85MP0002723_abnormal_immune_serum0.87390151
86MP0002970_abnormal_white_adipose0.87211436
87MP0002060_abnormal_skin_morphology0.86462566
88MP0000609_abnormal_liver_physiology0.86416684
89MP0000689_abnormal_spleen_morphology0.85012792
90MP0005666_abnormal_adipose_tissue0.84273886
91MP0002111_abnormal_tail_morphology0.84203014
92MP0009697_abnormal_copulation0.83979450
93MP0002722_abnormal_immune_system0.83737793
94MP0000598_abnormal_liver_morphology0.83526796
95MP0001881_abnormal_mammary_gland0.83376907
96MP0003566_abnormal_cell_adhesion0.83103285
97MP0000703_abnormal_thymus_morphology0.82940756
98MP0005621_abnormal_cell_physiology0.82880568
99MP0005076_abnormal_cell_differentiation0.82115040
100MP0003705_abnormal_hypodermis_morpholog0.81024567
101MP0004145_abnormal_muscle_electrophysio0.80911720
102MP0002452_abnormal_antigen_presenting0.80740796
103MP0001119_abnormal_female_reproductive0.80699014
104MP0000653_abnormal_sex_gland0.80504061
105MP0004381_abnormal_hair_follicle0.80460647
106MP0003941_abnormal_skin_development0.80145866
107MP0003959_abnormal_lean_body0.79572994
108MP0002398_abnormal_bone_marrow0.79570606
109MP0002160_abnormal_reproductive_system0.79436717
110MP0002269_muscular_atrophy0.79299885
111MP0005220_abnormal_exocrine_pancreas0.79266310
112MP0005085_abnormal_gallbladder_physiolo0.78769375
113MP0005389_reproductive_system_phenotype0.78417579
114MP0003315_abnormal_perineum_morphology0.78077065
115MP0005330_cardiomyopathy0.77460824
116MP0000858_altered_metastatic_potential0.76762575
117MP0002653_abnormal_ependyma_morphology0.75667286
118MP0005025_abnormal_response_to0.74569085
119MP0008438_abnormal_cutaneous_collagen0.74555384
120MP0002163_abnormal_gland_morphology0.74156868
121MP0005083_abnormal_biliary_tract0.73486807
122MP0001929_abnormal_gametogenesis0.73485842
123MP0001790_abnormal_immune_system0.72494624
124MP0005387_immune_system_phenotype0.72494624
125MP0005000_abnormal_immune_tolerance0.72281125
126MP0000759_abnormal_skeletal_muscle0.72138540
127MP0005365_abnormal_bile_salt0.72057386
128MP0000750_abnormal_muscle_regeneration0.71498859
129MP0000371_diluted_coat_color0.70884745
130MP0002429_abnormal_blood_cell0.68092131
131MP0005501_abnormal_skin_physiology0.67615505
132MP0002139_abnormal_hepatobiliary_system0.67404152
133MP0000477_abnormal_intestine_morphology0.67257297
134MP0002132_abnormal_respiratory_system0.67099346
135MP0001849_ear_inflammation0.66994357
136MP0005395_other_phenotype0.65754167
137MP0005075_abnormal_melanosome_morpholog0.63478404
138MP0005319_abnormal_enzyme/_coenzyme0.61808068
139MP0001919_abnormal_reproductive_system0.61141098
140MP0001915_intracranial_hemorrhage0.59406362
141MP0002877_abnormal_melanocyte_morpholog0.58210185
142MP0003943_abnormal_hepatobiliary_system0.57615942
143MP0009703_decreased_birth_body0.57053362
144MP0009053_abnormal_anal_canal0.56870802
145MP0004233_abnormal_muscle_weight0.55457546
146MP0005332_abnormal_amino_acid0.55415002
147MP0004084_abnormal_cardiac_muscle0.54544936
148MP0003699_abnormal_female_reproductive0.53558657

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.00028857
2Breast hypoplasia (HP:0003187)4.91561560
3Degeneration of anterior horn cells (HP:0002398)3.89538487
4Abnormality of the anterior horn cell (HP:0006802)3.89538487
5Oral leukoplakia (HP:0002745)3.89059524
6Ependymoma (HP:0002888)3.81901185
7Carpal bone hypoplasia (HP:0001498)3.70336235
8Colon cancer (HP:0003003)3.46412274
9Reticulocytopenia (HP:0001896)3.33575636
10Abnormality of glycolysis (HP:0004366)3.29230818
11Patellar aplasia (HP:0006443)3.27596315
12Rough bone trabeculation (HP:0100670)3.22750829
13Fatigue (HP:0012378)3.21180552
14Medulloblastoma (HP:0002885)3.15527084
15Entropion (HP:0000621)3.11290594
16Abnormality of T cell physiology (HP:0011840)3.06386230
17Abnormality of the labia minora (HP:0012880)3.04593406
18Cerebral hypomyelination (HP:0006808)3.04239221
19Aplasia/Hypoplasia of the patella (HP:0006498)3.02824717
20Increased serum pyruvate (HP:0003542)3.01860989
21Abnormality of cells of the erythroid lineage (HP:0012130)3.00115479
22Agnosia (HP:0010524)2.97539867
23Abnormality of pyrimidine metabolism (HP:0004353)2.93436604
24Seborrheic dermatitis (HP:0001051)2.91984178
25Aplastic anemia (HP:0001915)2.91831260
26Hypertensive crisis (HP:0100735)2.90072297
27Selective tooth agenesis (HP:0001592)2.89931192
28Absent radius (HP:0003974)2.86111619
29Impulsivity (HP:0100710)2.85965376
30Multiple enchondromatosis (HP:0005701)2.84684454
31Rhabdomyosarcoma (HP:0002859)2.83145749
32Abnormal number of erythroid precursors (HP:0012131)2.78156824
33Panhypogammaglobulinemia (HP:0003139)2.78129818
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.77645149
35Abnormality of reticulocytes (HP:0004312)2.75980546
36Absent thumb (HP:0009777)2.70595257
37Agammaglobulinemia (HP:0004432)2.70579667
38Ragged-red muscle fibers (HP:0003200)2.69668748
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65681775
40Colitis (HP:0002583)2.64302749
41Aplasia involving forearm bones (HP:0009822)2.62957077
42Absent forearm bone (HP:0003953)2.62957077
43Cholecystitis (HP:0001082)2.60916450
44Abnormal gallbladder physiology (HP:0012438)2.60916450
45Cutaneous melanoma (HP:0012056)2.58941322
46Abnormality of alanine metabolism (HP:0010916)2.56653309
47Hyperalaninemia (HP:0003348)2.56653309
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56653309
49Microretrognathia (HP:0000308)2.56338354
50Trismus (HP:0000211)2.52896865
51Macrocytic anemia (HP:0001972)2.52158311
52Megaloblastic anemia (HP:0001889)2.51501867
53Rhabdomyolysis (HP:0003201)2.50512308
54Neoplasm of the pancreas (HP:0002894)2.50330084
55Gastrointestinal stroma tumor (HP:0100723)2.43623384
56Meckel diverticulum (HP:0002245)2.43152901
57Redundant skin (HP:0001582)2.42479303
58Chromsome breakage (HP:0040012)2.41038165
59Basal cell carcinoma (HP:0002671)2.40037494
60Reduced antithrombin III activity (HP:0001976)2.38595045
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38078794
62Hyperglycinemia (HP:0002154)2.38046394
63Bone marrow hypocellularity (HP:0005528)2.36590610
64Abnormality of methionine metabolism (HP:0010901)2.36061504
65Reticulocytosis (HP:0001923)2.35630341
66Abnormal hemoglobin (HP:0011902)2.33168051
67Abnormality of chromosome stability (HP:0003220)2.32676463
68Abnormality of the preputium (HP:0100587)2.32663762
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.31863247
70Recurrent viral infections (HP:0004429)2.30911846
71Abnormality of the ileum (HP:0001549)2.29508223
72Cellular immunodeficiency (HP:0005374)2.28989679
73Premature graying of hair (HP:0002216)2.28973184
74Myelodysplasia (HP:0002863)2.25715566
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.25180838
76Hypobetalipoproteinemia (HP:0003563)2.24744963
77Vertebral compression fractures (HP:0002953)2.23448573
78Abnormal trabecular bone morphology (HP:0100671)2.19925840
79Hyperthyroidism (HP:0000836)2.19700056
80Acute lymphatic leukemia (HP:0006721)2.17068358
81Neoplasm of head and neck (HP:0012288)2.16700995
82Esophageal neoplasm (HP:0100751)2.16700995
83Poikiloderma (HP:0001029)2.15178497
84Aplasia/hypoplasia of the humerus (HP:0006507)2.14739515
85Gastrointestinal inflammation (HP:0004386)2.14291804
86Glioma (HP:0009733)2.12737457
87Premature ovarian failure (HP:0008209)2.10496587
88Abnormality of T cells (HP:0002843)2.10450885
89Horseshoe kidney (HP:0000085)2.08850903
90Astrocytoma (HP:0009592)2.08510597
91Abnormality of the astrocytes (HP:0100707)2.08510597
92Abnormality of serum amino acid levels (HP:0003112)2.08507894
93Supernumerary spleens (HP:0009799)2.08315518
94Pallor (HP:0000980)2.05991078
95Abdominal situs inversus (HP:0003363)2.05448989
96Abnormality of abdominal situs (HP:0011620)2.05448989
97Exercise-induced myalgia (HP:0003738)2.05126757
98Amaurosis fugax (HP:0100576)2.04371240
99Myoglobinuria (HP:0002913)2.04244449
100Neoplasm of striated muscle (HP:0009728)2.04004645
101Pancytopenia (HP:0001876)2.03915401
102Atrophy/Degeneration involving motor neurons (HP:0007373)2.01877170
103Truncus arteriosus (HP:0001660)2.01652197
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01515358
105Hyperammonemia (HP:0001987)2.00590385
106Abnormality of the umbilical cord (HP:0010881)1.99901793
107Biliary tract neoplasm (HP:0100574)1.99158715
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.98613033
109Hyperglycinuria (HP:0003108)1.98242448
110Neoplasm of the oral cavity (HP:0100649)1.97067521
111Cholelithiasis (HP:0001081)1.96766940
112Secondary amenorrhea (HP:0000869)1.96511569
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96471991
114Squamous cell carcinoma (HP:0002860)1.95497407
115Progressive muscle weakness (HP:0003323)1.95221675
116Sloping forehead (HP:0000340)1.94925244
117Viral hepatitis (HP:0006562)1.93251900
118Inflammation of the large intestine (HP:0002037)1.92936693
119Neoplasm of the colon (HP:0100273)1.92743621
120Microvesicular hepatic steatosis (HP:0001414)1.92117273
121Conjunctival hamartoma (HP:0100780)1.91496077
122Abnormal biliary tract morphology (HP:0012440)1.90496377
123Melanoma (HP:0002861)1.89754509
124Acute myeloid leukemia (HP:0004808)1.88044662
125Villous atrophy (HP:0011473)1.87355261
126Abnormality of small intestinal villus morphology (HP:0011472)1.87355261
127Autoimmune hemolytic anemia (HP:0001890)1.86334613
128Abnormality of DNA repair (HP:0003254)1.85640052
129Increased intramyocellular lipid droplets (HP:0012240)1.85570430
130Nausea (HP:0002018)1.85209148
131Premature skin wrinkling (HP:0100678)1.83496262
132Abnormality of cochlea (HP:0000375)1.83377605
133Shawl scrotum (HP:0000049)1.82899518
134Duodenal stenosis (HP:0100867)1.82337853
135Small intestinal stenosis (HP:0012848)1.82337853
136Spinal cord lesions (HP:0100561)1.82073574
137Syringomyelia (HP:0003396)1.82073574
138Abnormality of serine family amino acid metabolism (HP:0010894)1.81853930
139Abnormality of glycine metabolism (HP:0010895)1.81853930
140Type I transferrin isoform profile (HP:0003642)1.81722084
141Thrombocytosis (HP:0001894)1.81474872
142Sparse eyelashes (HP:0000653)1.81164461
143Breast aplasia (HP:0100783)1.81050597
144Atresia of the external auditory canal (HP:0000413)1.79857064
145Abnormality of homocysteine metabolism (HP:0010919)1.79507744
146Homocystinuria (HP:0002156)1.79507744
147CNS hypomyelination (HP:0003429)1.78323294
148Tracheoesophageal fistula (HP:0002575)1.77720587
149Biconcave vertebral bodies (HP:0004586)1.77703620
150Abnormal protein glycosylation (HP:0012346)1.77629518
151Abnormal glycosylation (HP:0012345)1.77629518
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77629518
153Abnormal protein N-linked glycosylation (HP:0012347)1.77629518
154Myopathic facies (HP:0002058)1.77591053
155Adenoma sebaceum (HP:0009720)1.77479916
156Angiofibromas (HP:0010615)1.77479916
157Abnormality of the duodenum (HP:0002246)1.77331570
158Ovarian neoplasm (HP:0100615)1.75614297
159Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75599684
160Slender long bone (HP:0003100)1.75586044
161Spastic paraparesis (HP:0002313)1.75287452
162Optic nerve coloboma (HP:0000588)1.74458395
163Increased serum lactate (HP:0002151)1.73892685
164Overlapping toe (HP:0001845)1.72859556
165Thoracic kyphosis (HP:0002942)1.72734612
166Abnormality of sulfur amino acid metabolism (HP:0004339)1.72271128
167Abnormality of the thymus (HP:0000777)1.71865777
168Increased muscle lipid content (HP:0009058)1.71575005
169Ureteral duplication (HP:0000073)1.70453809
170Hepatitis (HP:0012115)1.70012516
171Hypoplasia of the pons (HP:0012110)1.69697858
172Verrucae (HP:0200043)1.68614308
173Papilloma (HP:0012740)1.68614308
174Acute hepatic failure (HP:0006554)1.67461473
175Short middle phalanx of the 5th finger (HP:0004220)1.66911231
176Lower limb hyperreflexia (HP:0002395)1.66372499
177Reduced subcutaneous adipose tissue (HP:0003758)1.66296113
178Abnormality of the pons (HP:0007361)1.65571500
179Abnormality of the intrinsic pathway (HP:0010989)1.64974308
180Abnormality of the fetal cardiovascular system (HP:0010948)1.64577273
181Single umbilical artery (HP:0001195)1.64577273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.61118534
2WEE14.44338763
3CDC73.55167125
4TRIB33.30409453
5EIF2AK13.25219118
6EPHA23.08344193
7TSSK62.85098555
8NEK12.81647595
9SMG12.54313336
10TTK2.41591250
11SRPK12.39850542
12NEK22.39319100
13PRPF4B2.27496468
14EIF2AK32.10984770
15BMPR22.09449407
16BRSK22.02311003
17NME22.00386202
18BCKDK1.95965292
19PASK1.95707187
20TESK21.93182423
21RPS6KB21.92691736
22PLK11.91055092
23PLK41.90699543
24ACVR1B1.89678569
25STK161.78588176
26RIPK41.76594042
27VRK11.75201548
28CDK71.72332204
29VRK21.70788835
30PLK31.63121477
31CLK11.61275458
32FLT31.58789487
33ATR1.54718015
34DYRK31.50933572
35AURKB1.46160127
36MAP3K81.36295814
37CHEK21.36068799
38TLK11.32661102
39AKT31.32629199
40AURKA1.31108223
41RPS6KA41.30908448
42MKNK11.29544876
43CDK121.28304433
44IRAK41.27200968
45PAK41.26376435
46PKN21.19247429
47SCYL21.19200855
48ICK1.16345465
49CDK41.16239952
50MAPKAPK51.10723691
51STK101.09636837
52KSR21.08713445
53ZAK1.06467617
54CHEK11.05564194
55STK41.05514454
56TRPM71.03950048
57BRSK11.02980670
58TGFBR11.00118158
59EEF2K0.96078161
60BTK0.92691948
61MAP3K130.92375925
62ERN10.91584703
63CCNB10.89792422
64STK38L0.86764477
65BRAF0.85730458
66KDR0.85080904
67TBK10.84503091
68TAOK20.84141594
69ILK0.83864744
70BRD40.81937050
71PRKCI0.80534753
72MAPKAPK30.78214935
73PIM10.77914444
74CDK20.77603805
75MKNK20.76776070
76ATM0.71915689
77ALK0.71038116
78CSNK2A20.70586317
79MAP3K140.70272233
80RAF10.69887738
81MAP4K10.69632977
82MARK30.68657508
83SIK10.68377211
84CSNK2A10.67441585
85MAP2K60.66635548
86PNCK0.65588279
87PDK40.65008054
88PDK30.65008054
89MAP2K30.63889361
90TESK10.61757095
91MAP3K110.59343413
92ZAP700.58784107
93TAOK30.58350177
94MST1R0.55996602
95LRRK20.55316964
96EIF2AK20.54286439
97ITK0.54209239
98HIPK20.53970394
99MAP3K100.52928973
100PAK10.52891032
101PIM20.52805187
102MTOR0.51714966
103CDK60.49848441
104IKBKB0.49280670
105CDK10.48094858
106TEC0.47432664
107NME10.47222818
108TXK0.47131077
109PBK0.45745305
110SYK0.44026965
111PDK20.38207617
112MELK0.36779427
113AKT20.35151409
114RPS6KA50.34968666
115NEK90.34225614
116NLK0.33365047
117GRK60.32405741
118STK30.32180254
119JAK30.31065155
120TYK20.30930568
121DAPK10.30679432
122CSNK1E0.30260317
123MAP3K50.28637856
124FGFR10.28218836
125DYRK20.27013863
126MAPK110.25905539
127IRAK30.25301378
128MAP2K20.25178194
129CDK80.25088522
130PRKDC0.24552796
131MAP3K30.23396905

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60609130
2Mismatch repair_Homo sapiens_hsa034304.20485231
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44386100
4Proteasome_Homo sapiens_hsa030503.44052536
5RNA polymerase_Homo sapiens_hsa030203.17373100
6One carbon pool by folate_Homo sapiens_hsa006703.04959233
7Ribosome_Homo sapiens_hsa030102.90787457
8RNA transport_Homo sapiens_hsa030132.84491886
9Base excision repair_Homo sapiens_hsa034102.83454478
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82124459
11Spliceosome_Homo sapiens_hsa030402.80963003
12Nucleotide excision repair_Homo sapiens_hsa034202.70293359
13Homologous recombination_Homo sapiens_hsa034402.60675367
14Pyrimidine metabolism_Homo sapiens_hsa002402.42595231
15Cell cycle_Homo sapiens_hsa041102.33618271
16Fanconi anemia pathway_Homo sapiens_hsa034601.70114900
17Basal transcription factors_Homo sapiens_hsa030221.62344738
18RNA degradation_Homo sapiens_hsa030181.55859319
19Selenocompound metabolism_Homo sapiens_hsa004501.53746664
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52550282
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.50956092
22Non-homologous end-joining_Homo sapiens_hsa034501.49180605
23Biosynthesis of amino acids_Homo sapiens_hsa012301.48378027
24Folate biosynthesis_Homo sapiens_hsa007901.47504770
25p53 signaling pathway_Homo sapiens_hsa041151.42915498
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40314754
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.39071451
28Other glycan degradation_Homo sapiens_hsa005111.31683936
29mRNA surveillance pathway_Homo sapiens_hsa030151.29779688
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.29223208
31Purine metabolism_Homo sapiens_hsa002301.21920486
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20932124
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15670696
34Vitamin B6 metabolism_Homo sapiens_hsa007501.13805375
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13384737
36B cell receptor signaling pathway_Homo sapiens_hsa046621.12133148
37Carbon metabolism_Homo sapiens_hsa012001.12086960
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10468807
39Non-small cell lung cancer_Homo sapiens_hsa052231.07251050
40Acute myeloid leukemia_Homo sapiens_hsa052211.05646713
41Pentose phosphate pathway_Homo sapiens_hsa000301.02089389
42Epstein-Barr virus infection_Homo sapiens_hsa051691.01093837
43Sulfur relay system_Homo sapiens_hsa041221.00474565
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.94621461
45Glutathione metabolism_Homo sapiens_hsa004800.93943430
46Chronic myeloid leukemia_Homo sapiens_hsa052200.90594574
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90002523
48Measles_Homo sapiens_hsa051620.89208682
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88005814
50Fructose and mannose metabolism_Homo sapiens_hsa000510.83895764
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79307195
52Pancreatic cancer_Homo sapiens_hsa052120.74557615
53Fatty acid elongation_Homo sapiens_hsa000620.72854184
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.72658009
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72357310
56Systemic lupus erythematosus_Homo sapiens_hsa053220.72153358
57Sulfur metabolism_Homo sapiens_hsa009200.71555898
58Thyroid cancer_Homo sapiens_hsa052160.71449249
59Herpes simplex infection_Homo sapiens_hsa051680.69485729
60Viral carcinogenesis_Homo sapiens_hsa052030.67391462
61mTOR signaling pathway_Homo sapiens_hsa041500.66759383
62Protein export_Homo sapiens_hsa030600.66617148
63Influenza A_Homo sapiens_hsa051640.65411535
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64471136
65Hepatitis B_Homo sapiens_hsa051610.64453334
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62033233
67Antigen processing and presentation_Homo sapiens_hsa046120.61181892
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60620285
69Oocyte meiosis_Homo sapiens_hsa041140.58773655
70T cell receptor signaling pathway_Homo sapiens_hsa046600.57489834
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54675515
72Galactose metabolism_Homo sapiens_hsa000520.54527517
73Autoimmune thyroid disease_Homo sapiens_hsa053200.53180723
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52646018
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51250941
76Allograft rejection_Homo sapiens_hsa053300.50043989
77Insulin resistance_Homo sapiens_hsa049310.48291022
78Pyruvate metabolism_Homo sapiens_hsa006200.47940125
79Arginine and proline metabolism_Homo sapiens_hsa003300.47508794
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46516165
81HTLV-I infection_Homo sapiens_hsa051660.46469383
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45816297
83Legionellosis_Homo sapiens_hsa051340.45157554
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44628080
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44602542
86Metabolic pathways_Homo sapiens_hsa011000.41576506
87VEGF signaling pathway_Homo sapiens_hsa043700.41515170
88Asthma_Homo sapiens_hsa053100.40523720
89Leishmaniasis_Homo sapiens_hsa051400.39811316
90Toxoplasmosis_Homo sapiens_hsa051450.37855866
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37110509
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36360468
93Viral myocarditis_Homo sapiens_hsa054160.34065801
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.33957561
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33629853
96Peroxisome_Homo sapiens_hsa041460.33156167
97Regulation of autophagy_Homo sapiens_hsa041400.32361705
98Graft-versus-host disease_Homo sapiens_hsa053320.31010023
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30905522
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30769381
101Fatty acid degradation_Homo sapiens_hsa000710.29327940
102Colorectal cancer_Homo sapiens_hsa052100.29007535
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27824797
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27650301
105beta-Alanine metabolism_Homo sapiens_hsa004100.27330384
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26680787
107Huntingtons disease_Homo sapiens_hsa050160.26542266
108Propanoate metabolism_Homo sapiens_hsa006400.25133854
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24959788
110Primary immunodeficiency_Homo sapiens_hsa053400.24235541
111Small cell lung cancer_Homo sapiens_hsa052220.22919462
112MicroRNAs in cancer_Homo sapiens_hsa052060.22722429
113N-Glycan biosynthesis_Homo sapiens_hsa005100.21909854
114Arginine biosynthesis_Homo sapiens_hsa002200.21771155
115Lysine degradation_Homo sapiens_hsa003100.20929789
116Apoptosis_Homo sapiens_hsa042100.20853078
117Renin-angiotensin system_Homo sapiens_hsa046140.20119097
118Caffeine metabolism_Homo sapiens_hsa002320.19758126
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19656598
120Tryptophan metabolism_Homo sapiens_hsa003800.19291420
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.18629985
122Vitamin digestion and absorption_Homo sapiens_hsa049770.18587060
123Arachidonic acid metabolism_Homo sapiens_hsa005900.17765808
124Chemical carcinogenesis_Homo sapiens_hsa052040.17689290
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16710334
126Bladder cancer_Homo sapiens_hsa052190.16634767
127Hippo signaling pathway_Homo sapiens_hsa043900.16166134
128Phenylalanine metabolism_Homo sapiens_hsa003600.16005466
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15384748
130Fat digestion and absorption_Homo sapiens_hsa049750.15350349
131Retinol metabolism_Homo sapiens_hsa008300.13735080
132Tyrosine metabolism_Homo sapiens_hsa003500.12191013

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