EIF2S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.61657161
2nucleobase biosynthetic process (GO:0046112)4.57562988
3DNA replication initiation (GO:0006270)4.50864822
4formation of translation preinitiation complex (GO:0001731)4.45284997
5purine nucleobase biosynthetic process (GO:0009113)4.44994517
6maturation of SSU-rRNA (GO:0030490)4.37518052
7DNA strand elongation (GO:0022616)4.37514818
8telomere maintenance via semi-conservative replication (GO:0032201)4.35075797
9ribosomal small subunit assembly (GO:0000028)4.19392485
10mitotic metaphase plate congression (GO:0007080)4.16121008
11ribosomal large subunit biogenesis (GO:0042273)4.15374248
12DNA double-strand break processing (GO:0000729)4.13648420
13DNA replication checkpoint (GO:0000076)4.13055101
14proteasome assembly (GO:0043248)4.04581081
15CENP-A containing nucleosome assembly (GO:0034080)4.02881561
16DNA unwinding involved in DNA replication (GO:0006268)4.00137776
17ribosome biogenesis (GO:0042254)3.99504501
18telomere maintenance via recombination (GO:0000722)3.98820749
19IMP biosynthetic process (GO:0006188)3.95077918
20ribosome assembly (GO:0042255)3.94349003
21chromatin remodeling at centromere (GO:0031055)3.93860134
22protein localization to kinetochore (GO:0034501)3.89092851
23ribonucleoprotein complex biogenesis (GO:0022613)3.85493473
24mitotic recombination (GO:0006312)3.81168927
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79466806
26DNA replication-dependent nucleosome assembly (GO:0006335)3.79408591
27DNA replication-dependent nucleosome organization (GO:0034723)3.79408591
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75217323
29mitotic nuclear envelope disassembly (GO:0007077)3.72580900
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70869011
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68522728
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66978741
33double-strand break repair via nonhomologous end joining (GO:0006303)3.64761060
34non-recombinational repair (GO:0000726)3.64761060
35establishment of viral latency (GO:0019043)3.64081884
36DNA replication-independent nucleosome assembly (GO:0006336)3.61214800
37DNA replication-independent nucleosome organization (GO:0034724)3.61214800
38maturation of 5.8S rRNA (GO:0000460)3.58808966
39telomere maintenance via telomere lengthening (GO:0010833)3.58067936
40kinetochore organization (GO:0051383)3.55762899
41metaphase plate congression (GO:0051310)3.54272702
42folic acid-containing compound biosynthetic process (GO:0009396)3.53449099
43rRNA processing (GO:0006364)3.52510079
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52390696
45nuclear pore organization (GO:0006999)3.51217132
46IMP metabolic process (GO:0046040)3.48747778
47spliceosomal snRNP assembly (GO:0000387)3.48168808
48DNA deamination (GO:0045006)3.47868006
49translational termination (GO:0006415)3.45544640
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.45069931
51negative regulation of ligase activity (GO:0051352)3.44429336
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44429336
53regulation of ligase activity (GO:0051340)3.43335058
54nuclear envelope disassembly (GO:0051081)3.42807677
55membrane disassembly (GO:0030397)3.42807677
56viral transcription (GO:0019083)3.42474423
57rRNA metabolic process (GO:0016072)3.41461165
58histone exchange (GO:0043486)3.40829111
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.39139872
60DNA catabolic process, exonucleolytic (GO:0000738)3.38362706
61ribosomal small subunit biogenesis (GO:0042274)3.37784730
62cell cycle G1/S phase transition (GO:0044843)3.37523673
63G1/S transition of mitotic cell cycle (GO:0000082)3.37523673
64sister chromatid segregation (GO:0000819)3.37116739
65attachment of spindle microtubules to kinetochore (GO:0008608)3.33938538
66* translational initiation (GO:0006413)3.33671459
67protein localization to chromosome, centromeric region (GO:0071459)3.32288194
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30567444
69establishment of chromosome localization (GO:0051303)3.29897822
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29299223
71rRNA methylation (GO:0031167)3.29121516
72tRNA aminoacylation for protein translation (GO:0006418)3.27514392
73transcription-coupled nucleotide-excision repair (GO:0006283)3.27325509
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26725721
75cullin deneddylation (GO:0010388)3.26064708
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25409209
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25409209
78amino acid activation (GO:0043038)3.23959896
79tRNA aminoacylation (GO:0043039)3.23959896
80DNA ligation (GO:0006266)3.23783403
81translational elongation (GO:0006414)3.23569823
82protein K6-linked ubiquitination (GO:0085020)3.23468028
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23206586
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23206586
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23206586
86rRNA modification (GO:0000154)3.22634482
87regulation of spindle organization (GO:0090224)3.22442315
88nuclear pore complex assembly (GO:0051292)3.20378155
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.19486783
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19486783
91regulation of centriole replication (GO:0046599)3.19331387
92replication fork processing (GO:0031297)3.18610685
93kinetochore assembly (GO:0051382)3.18181403
94pseudouridine synthesis (GO:0001522)3.16261747
95regulation of cellular amino acid metabolic process (GO:0006521)3.16174834
96mitotic spindle checkpoint (GO:0071174)3.15901524
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.15166348
98mitotic sister chromatid cohesion (GO:0007064)3.14650109
99positive regulation of ligase activity (GO:0051351)3.10780442
100somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.09955257
101isotype switching (GO:0045190)3.09955257
102somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.09955257
103establishment of integrated proviral latency (GO:0075713)3.09187612
104protein deneddylation (GO:0000338)3.08325982
105DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06979948
106termination of RNA polymerase III transcription (GO:0006386)3.06440091
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.06440091
108negative regulation of protein ubiquitination (GO:0031397)3.06264147
109termination of RNA polymerase I transcription (GO:0006363)3.06212854
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05670789
111chaperone-mediated protein transport (GO:0072321)3.05540760
1127-methylguanosine mRNA capping (GO:0006370)3.05479005
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04549003
114transcription from mitochondrial promoter (GO:0006390)3.04164549
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03816415
116positive regulation of cell cycle arrest (GO:0071158)3.02280372
117pteridine-containing compound biosynthetic process (GO:0042559)3.01624948
118nucleobase-containing small molecule interconversion (GO:0015949)3.01577753
119regulation of DNA endoreduplication (GO:0032875)3.01481140
120mitochondrial RNA metabolic process (GO:0000959)3.01177987
121RNA capping (GO:0036260)3.00621397
1227-methylguanosine RNA capping (GO:0009452)3.00621397
123transcription elongation from RNA polymerase I promoter (GO:0006362)3.00607001
124cellular component biogenesis (GO:0044085)2.99899518
125* translation (GO:0006412)2.97818267
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97610292
127cotranslational protein targeting to membrane (GO:0006613)2.97166834
128mitotic sister chromatid segregation (GO:0000070)2.97158005
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95523411
130protein targeting to ER (GO:0045047)2.95159020
131spindle checkpoint (GO:0031577)2.94930952
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.94410621
133regulation of chromosome segregation (GO:0051983)2.94200832
134transcription from RNA polymerase I promoter (GO:0006360)2.94157455
135lactate metabolic process (GO:0006089)2.93492010
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.92871998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14486577
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54575057
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74411044
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71193287
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63119694
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.48663902
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.36125639
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.35101939
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12577128
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06622321
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06309057
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.06099830
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98330714
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97835820
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93635487
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52298735
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51632722
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44470429
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44053766
20* VDR_23849224_ChIP-Seq_CD4+_Human2.42300195
21XRN2_22483619_ChIP-Seq_HELA_Human2.37793244
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32666307
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30230591
24AR_21909140_ChIP-Seq_LNCAP_Human2.20530840
25DCP1A_22483619_ChIP-Seq_HELA_Human2.16829107
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15780629
27FOXP3_21729870_ChIP-Seq_TREG_Human2.07449278
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03520158
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.03258639
30ELK1_19687146_ChIP-ChIP_HELA_Human2.00019274
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99614949
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97280412
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95974276
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93980158
35GABP_19822575_ChIP-Seq_HepG2_Human1.92894471
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.89035314
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88260606
38TTF2_22483619_ChIP-Seq_HELA_Human1.87574742
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84663948
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83883001
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77945948
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76527991
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75335993
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74668487
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72950763
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65992024
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61971526
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.61020019
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.56191544
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55776432
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.55765356
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54508746
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50802434
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50195821
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40480876
56* KDM5A_27292631_Chip-Seq_BREAST_Human1.40409010
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38663077
58* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31702293
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29911119
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28077380
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27198909
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26470826
63CIITA_25753668_ChIP-Seq_RAJI_Human1.26400211
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25930902
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21891309
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20434253
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20258174
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19779903
69EWS_26573619_Chip-Seq_HEK293_Human1.19350796
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18910080
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18721387
72TFEB_21752829_ChIP-Seq_HELA_Human1.17968112
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16481772
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16355782
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.11469382
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11419401
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.10358490
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09413257
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09393993
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.07360572
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07309718
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03774548
83FUS_26573619_Chip-Seq_HEK293_Human1.03703061
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03100476
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02996370
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02289098
87MYC_22102868_ChIP-Seq_BL_Human0.99087365
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98646335
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.98384410
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98334179
91MYC_18940864_ChIP-ChIP_HL60_Human0.98162419
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96666244
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96658267
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96264099
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94693600
96SPI1_23547873_ChIP-Seq_NB4_Human0.92147236
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91558602
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89081452
99ELF5_23300383_ChIP-Seq_T47D_Human0.87937410
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.85977699
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85830498
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85653735
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85061637
104ZNF274_21170338_ChIP-Seq_K562_Hela0.84823931
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83458333
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83423426
107VDR_22108803_ChIP-Seq_LS180_Human0.82895143
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.80576249
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80436155
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77650029
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75692761
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73028922
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72312143
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71713858
115* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71485288
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71295771
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70682402
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.70359960
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70242797
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69915852
121SALL4_22934838_ChIP-ChIP_CD34+_Human0.67704010
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65837660
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65366483
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.65212859
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64417939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.84927169
2MP0004957_abnormal_blastocyst_morpholog4.74129185
3MP0010094_abnormal_chromosome_stability4.72972529
4MP0003111_abnormal_nucleus_morphology4.35629831
5MP0003077_abnormal_cell_cycle4.05719627
6MP0008057_abnormal_DNA_replication4.01976569
7MP0008058_abnormal_DNA_repair3.54716929
8MP0008007_abnormal_cellular_replicative3.05115572
9MP0008932_abnormal_embryonic_tissue3.01683395
10MP0003950_abnormal_plasma_membrane2.67670404
11MP0003123_paternal_imprinting2.55897836
12MP0001730_embryonic_growth_arrest2.41983940
13MP0000372_irregular_coat_pigmentation2.38471526
14MP0002396_abnormal_hematopoietic_system2.33310736
15MP0000350_abnormal_cell_proliferation2.23468840
16MP0003786_premature_aging2.22528026
17MP0010352_gastrointestinal_tract_polyps2.21468472
18MP0003806_abnormal_nucleotide_metabolis1.97637085
19MP0008877_abnormal_DNA_methylation1.96964413
20MP0010234_abnormal_vibrissa_follicle1.89795078
21MP0010307_abnormal_tumor_latency1.88765176
22MP0003718_maternal_effect1.85128950
23MP0002102_abnormal_ear_morphology1.77854972
24MP0001697_abnormal_embryo_size1.68796684
25MP0001672_abnormal_embryogenesis/_devel1.63321716
26MP0005380_embryogenesis_phenotype1.63321716
27MP0000490_abnormal_crypts_of1.58119378
28MP0002080_prenatal_lethality1.53499542
29MP0003984_embryonic_growth_retardation1.50030783
30MP0003186_abnormal_redox_activity1.49200404
31MP0009333_abnormal_splenocyte_physiolog1.48579415
32MP0002088_abnormal_embryonic_growth/wei1.46075830
33MP0000313_abnormal_cell_death1.43638885
34MP0006072_abnormal_retinal_apoptosis1.42358018
35MP0002019_abnormal_tumor_incidence1.40498842
36MP0002938_white_spotting1.37393393
37MP0002085_abnormal_embryonic_tissue1.32426976
38MP0004808_abnormal_hematopoietic_stem1.26693871
39MP0001529_abnormal_vocalization1.26082332
40MP0002877_abnormal_melanocyte_morpholog1.25045038
41MP0002086_abnormal_extraembryonic_tissu1.23515857
42MP0003567_abnormal_fetal_cardiomyocyte1.22483108
43MP0003315_abnormal_perineum_morphology1.20899837
44* MP0004197_abnormal_fetal_growth/weight/1.18362742
45MP0000749_muscle_degeneration1.17941880
46MP0002210_abnormal_sex_determination1.17487571
47MP0002084_abnormal_developmental_patter1.16666699
48MP0010030_abnormal_orbit_morphology1.11976273
49MP0001661_extended_life_span1.11612923
50MP0003763_abnormal_thymus_physiology1.10891203
51MP0002234_abnormal_pharynx_morphology1.09876105
52MP0002090_abnormal_vision1.08300263
53MP0000647_abnormal_sebaceous_gland1.07315287
54MP0001545_abnormal_hematopoietic_system1.06514830
55MP0005397_hematopoietic_system_phenotyp1.06514830
56MP0001293_anophthalmia1.05437980
57MP0000858_altered_metastatic_potential1.03855709
58MP0002160_abnormal_reproductive_system1.03635526
59MP0000358_abnormal_cell_content/1.02873429
60MP0002398_abnormal_bone_marrow1.02631607
61MP0001145_abnormal_male_reproductive1.02397255
62MP0002722_abnormal_immune_system0.99930799
63MP0000689_abnormal_spleen_morphology0.98293987
64MP0000703_abnormal_thymus_morphology0.98017454
65MP0000427_abnormal_hair_cycle0.96443914
66MP0003121_genomic_imprinting0.96177348
67MP0005395_other_phenotype0.95077823
68MP0001853_heart_inflammation0.94932161
69MP0003890_abnormal_embryonic-extraembry0.94041963
70MP0003221_abnormal_cardiomyocyte_apopto0.93170150
71MP0005389_reproductive_system_phenotype0.90313569
72MP0006054_spinal_hemorrhage0.89556703
73MP0004215_abnormal_myocardial_fiber0.89045423
74MP0005171_absent_coat_pigmentation0.88682839
75MP0001929_abnormal_gametogenesis0.86811748
76MP0001542_abnormal_bone_strength0.86422041
77MP0005023_abnormal_wound_healing0.85728974
78MP0001881_abnormal_mammary_gland0.85548000
79MP0000653_abnormal_sex_gland0.85302129
80MP0009697_abnormal_copulation0.84595366
81MP0002132_abnormal_respiratory_system0.83826672
82MP0002060_abnormal_skin_morphology0.83665993
83MP0001119_abnormal_female_reproductive0.83590438
84MP0003941_abnormal_skin_development0.83410602
85MP0002095_abnormal_skin_pigmentation0.82788974
86MP0005384_cellular_phenotype0.81719169
87* MP0002429_abnormal_blood_cell0.81635681
88MP0002751_abnormal_autonomic_nervous0.80778341
89MP0005253_abnormal_eye_physiology0.79822444
90MP0004233_abnormal_muscle_weight0.79483262
91MP0005076_abnormal_cell_differentiation0.79219064
92MP0001835_abnormal_antigen_presentation0.78741221
93MP0002006_tumorigenesis0.78347724
94MP0006036_abnormal_mitochondrial_physio0.78053599
95MP0005501_abnormal_skin_physiology0.77631394
96MP0009379_abnormal_foot_pigmentation0.76579186
97MP0005621_abnormal_cell_physiology0.73689361
98MP0006035_abnormal_mitochondrial_morpho0.72937378
99MP0005379_endocrine/exocrine_gland_phen0.72438454
100MP0005084_abnormal_gallbladder_morpholo0.72428514
101MP0000750_abnormal_muscle_regeneration0.72182683
102MP0003755_abnormal_palate_morphology0.71992921
103MP0005075_abnormal_melanosome_morpholog0.71652676
104MP0005367_renal/urinary_system_phenotyp0.70322500
105MP0000516_abnormal_urinary_system0.70322500
106MP0002233_abnormal_nose_morphology0.69604509
107MP0010678_abnormal_skin_adnexa0.69556591
108MP0009780_abnormal_chondrocyte_physiolo0.69381112
109MP0000716_abnormal_immune_system0.69100845
110MP0002177_abnormal_outer_ear0.69061299
111MP0001919_abnormal_reproductive_system0.68990613
112MP0009053_abnormal_anal_canal0.68966718
113MP0008789_abnormal_olfactory_epithelium0.68163430
114MP0003448_altered_tumor_morphology0.67302783
115MP0002111_abnormal_tail_morphology0.67179059
116MP0003566_abnormal_cell_adhesion0.66700113
117MP0005330_cardiomyopathy0.66618895
118MP0009672_abnormal_birth_weight0.65826899
119MP0002282_abnormal_trachea_morphology0.65725397
120MP0000537_abnormal_urethra_morphology0.65149804
121MP0001727_abnormal_embryo_implantation0.64665859
122MP0003936_abnormal_reproductive_system0.64499484
123MP0000015_abnormal_ear_pigmentation0.64356118
124MP0003119_abnormal_digestive_system0.64212599
125MP0006292_abnormal_olfactory_placode0.63869990
126MP0000762_abnormal_tongue_morphology0.63672241
127MP0003937_abnormal_limbs/digits/tail_de0.62898144
128MP0001764_abnormal_homeostasis0.62692642
129MP0001800_abnormal_humoral_immune0.62072874
130MP0003011_delayed_dark_adaptation0.61938193
131MP0009785_altered_susceptibility_to0.61934673
132MP0005671_abnormal_response_to0.61743887
133MP0000627_abnormal_mammary_gland0.59991824
134MP0001243_abnormal_dermal_layer0.59713108
135MP0001915_intracranial_hemorrhage0.59637334
136MP0002452_abnormal_antigen_presenting0.59593797
137MP0005408_hypopigmentation0.57568225
138MP0004133_heterotaxia0.57415941
139MP0002420_abnormal_adaptive_immunity0.56709490
140MP0002405_respiratory_system_inflammati0.56528788
141MP0001286_abnormal_eye_development0.56268202
142MP0001819_abnormal_immune_cell0.55936887
143MP0002163_abnormal_gland_morphology0.55279085

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.59242332
2Breast hypoplasia (HP:0003187)4.15335856
3Abnormality of the anterior horn cell (HP:0006802)3.99499367
4Degeneration of anterior horn cells (HP:0002398)3.99499367
5Reticulocytopenia (HP:0001896)3.90821383
6Abnormality of cells of the erythroid lineage (HP:0012130)3.83383863
7Oral leukoplakia (HP:0002745)3.64408257
8Acute necrotizing encephalopathy (HP:0006965)3.59585318
9Abnormal number of erythroid precursors (HP:0012131)3.55950633
10Carpal bone hypoplasia (HP:0001498)3.51402509
11Acute encephalopathy (HP:0006846)3.40038150
12Cerebral hypomyelination (HP:0006808)3.36225925
13Selective tooth agenesis (HP:0001592)3.33383850
14Patellar aplasia (HP:0006443)3.29003617
15Rough bone trabeculation (HP:0100670)3.25308765
16Abnormal mitochondria in muscle tissue (HP:0008316)3.23859497
17Progressive macrocephaly (HP:0004481)3.18879329
18Abnormality of chromosome stability (HP:0003220)3.15079909
19Chromsome breakage (HP:0040012)3.13006492
20Aplasia/Hypoplasia of the patella (HP:0006498)3.07732234
21Mitochondrial inheritance (HP:0001427)3.02192681
22Colon cancer (HP:0003003)2.98338211
23Aplastic anemia (HP:0001915)2.97866347
24Abnormality of methionine metabolism (HP:0010901)2.97509663
25Lipid accumulation in hepatocytes (HP:0006561)2.89426734
26Abnormality of the preputium (HP:0100587)2.88205465
27Macrocytic anemia (HP:0001972)2.84920207
28Meckel diverticulum (HP:0002245)2.82681105
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81049544
30Agnosia (HP:0010524)2.78781450
31Hepatocellular necrosis (HP:0001404)2.75160849
32Abnormality of placental membranes (HP:0011409)2.74401436
33Amniotic constriction ring (HP:0009775)2.74401436
34Cerebral edema (HP:0002181)2.68903748
35Premature graying of hair (HP:0002216)2.68605459
36Abnormality of the ileum (HP:0001549)2.66197326
37Irregular epiphyses (HP:0010582)2.66180178
38Medulloblastoma (HP:0002885)2.65442892
39Trismus (HP:0000211)2.64827362
40Absent thumb (HP:0009777)2.59947381
41Hepatic necrosis (HP:0002605)2.55843794
42Pallor (HP:0000980)2.54129205
43Absent radius (HP:0003974)2.52129357
44Abnormal trabecular bone morphology (HP:0100671)2.48307805
45Abnormality of glycolysis (HP:0004366)2.48208760
46Increased serum pyruvate (HP:0003542)2.48208760
4711 pairs of ribs (HP:0000878)2.46536516
48Impulsivity (HP:0100710)2.45322684
49Neoplasm of the adrenal gland (HP:0100631)2.44602128
50Secondary amenorrhea (HP:0000869)2.43313337
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.37462179
52Multiple enchondromatosis (HP:0005701)2.36994398
53Microretrognathia (HP:0000308)2.34905721
54Myelodysplasia (HP:0002863)2.33953647
55Methylmalonic acidemia (HP:0002912)2.33718491
56Abnormality of the labia minora (HP:0012880)2.32836234
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32023763
58Duodenal stenosis (HP:0100867)2.31528646
59Small intestinal stenosis (HP:0012848)2.31528646
60Reduced antithrombin III activity (HP:0001976)2.31498229
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31433203
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31168852
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31168852
64Aplasia involving forearm bones (HP:0009822)2.30933227
65Absent forearm bone (HP:0003953)2.30933227
66Glioma (HP:0009733)2.30819844
67Bone marrow hypocellularity (HP:0005528)2.29562238
68Microvesicular hepatic steatosis (HP:0001414)2.29172782
69Premature ovarian failure (HP:0008209)2.28695596
70Glossoptosis (HP:0000162)2.27335616
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27083022
72Horseshoe kidney (HP:0000085)2.26151463
73Nephroblastoma (Wilms tumor) (HP:0002667)2.25324439
74Ependymoma (HP:0002888)2.24841424
75Poor head control (HP:0002421)2.24343050
76Neoplasm of the pancreas (HP:0002894)2.23447785
77Lactic acidosis (HP:0003128)2.23181925
78Abnormal lung lobation (HP:0002101)2.21963047
79Increased serum lactate (HP:0002151)2.21437122
80Cellular immunodeficiency (HP:0005374)2.20046218
81Volvulus (HP:0002580)2.19116407
82Abnormal protein glycosylation (HP:0012346)2.19004890
83Abnormal glycosylation (HP:0012345)2.19004890
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19004890
85Abnormal protein N-linked glycosylation (HP:0012347)2.19004890
86Embryonal renal neoplasm (HP:0011794)2.18375399
87Astrocytoma (HP:0009592)2.18051144
88Abnormality of the astrocytes (HP:0100707)2.18051144
89Abnormalities of placenta or umbilical cord (HP:0001194)2.17301448
90Posterior subcapsular cataract (HP:0007787)2.17089319
91Rhabdomyosarcoma (HP:0002859)2.16547025
92Atrophy/Degeneration involving motor neurons (HP:0007373)2.16092232
93Renal Fanconi syndrome (HP:0001994)2.15975912
94Supernumerary spleens (HP:0009799)2.09247963
953-Methylglutaconic aciduria (HP:0003535)2.08899851
96Sloping forehead (HP:0000340)2.08802978
97Cleft eyelid (HP:0000625)2.08256785
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07927674
99Abnormal number of incisors (HP:0011064)2.06919445
100Abnormality of the carotid arteries (HP:0005344)2.06180677
101Breast carcinoma (HP:0003002)2.04527777
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04043041
103Abnormality of alanine metabolism (HP:0010916)2.04043041
104Hyperalaninemia (HP:0003348)2.04043041
105Exercise intolerance (HP:0003546)2.03658757
106Slender long bone (HP:0003100)2.02382212
107Triphalangeal thumb (HP:0001199)2.02212974
108Sparse eyelashes (HP:0000653)2.02114142
109Respiratory failure (HP:0002878)2.02079553
110Squamous cell carcinoma (HP:0002860)2.01564191
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99250448
112Absent epiphyses (HP:0010577)1.99250448
113Lymphoma (HP:0002665)1.98504831
114Abnormal spermatogenesis (HP:0008669)1.97486084
115Neoplasm of the peripheral nervous system (HP:0100007)1.96191572
116Clubbing of toes (HP:0100760)1.95891703
117Abnormality of serum amino acid levels (HP:0003112)1.93248931
118Meningioma (HP:0002858)1.92296043
119Pancytopenia (HP:0001876)1.92229226
120Conjunctival hamartoma (HP:0100780)1.91694024
121Microglossia (HP:0000171)1.91450665
122Atresia of the external auditory canal (HP:0000413)1.90227314
123Basal cell carcinoma (HP:0002671)1.89864474
124Leukodystrophy (HP:0002415)1.89662280
125CNS hypomyelination (HP:0003429)1.88362700
126Abnormality of the duodenum (HP:0002246)1.87226426
127Megaloblastic anemia (HP:0001889)1.86893026
128Tracheoesophageal fistula (HP:0002575)1.86877106
129Increased CSF lactate (HP:0002490)1.86314642
130IgM deficiency (HP:0002850)1.86138927
131Thrombocytosis (HP:0001894)1.85050101
132Neoplasm of the colon (HP:0100273)1.84272257
133Sensory axonal neuropathy (HP:0003390)1.82436029
134Type I transferrin isoform profile (HP:0003642)1.82117884
135Abnormality of the fetal cardiovascular system (HP:0010948)1.81661815
136Abnormal umbilical cord blood vessels (HP:0011403)1.81661815
137Single umbilical artery (HP:0001195)1.81661815
138Methylmalonic aciduria (HP:0012120)1.81197008
139Deviation of the thumb (HP:0009603)1.80332396
140Abnormality of the umbilical cord (HP:0010881)1.79875741
141Postnatal microcephaly (HP:0005484)1.79859430
142Lethargy (HP:0001254)1.78701745
143Ectopic kidney (HP:0000086)1.77479862
144CNS demyelination (HP:0007305)1.77467626
145Proximal placement of thumb (HP:0009623)1.77237260
146Cutaneous melanoma (HP:0012056)1.76438194
147Increased hepatocellular lipid droplets (HP:0006565)1.75544243
148Hypokinesia (HP:0002375)1.74726365
149Increased nuchal translucency (HP:0010880)1.73299704
150Hypoplasia of the pons (HP:0012110)1.73297866
151Muscle fiber atrophy (HP:0100295)1.73125537
152Amaurosis fugax (HP:0100576)1.72955312
153Abnormality of the pons (HP:0007361)1.71418360
154Stenosis of the external auditory canal (HP:0000402)1.71310818
155Entropion (HP:0000621)1.70938690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.05679426
2WEE14.50474878
3CDC73.72584420
4VRK23.14020442
5SRPK12.90288932
6TSSK62.76587627
7TRIM282.76417614
8NME22.73589851
9PLK42.37567570
10ACVR1B2.33902301
11STK162.30113934
12BRSK22.25591361
13TESK22.25518516
14NEK22.17014584
15NEK12.13429253
16TTK2.12625779
17MKNK12.10496596
18VRK12.07775905
19PLK11.93074158
20PLK31.87543886
21MAP3K121.79951988
22* EIF2AK31.76666342
23PBK1.74501463
24TAF11.74308768
25AURKB1.64596847
26RPS6KA41.62059635
27ATR1.57745430
28BRSK11.55545723
29RPS6KB21.51811929
30PLK21.51132878
31TESK11.49273176
32TLK11.49097989
33MKNK21.47403465
34EPHA21.47135112
35CDK71.46754117
36ZAK1.40963093
37PASK1.36371727
38MST1R1.36306261
39PIM21.35538542
40AURKA1.27518987
41CCNB11.26635794
42MAP3K81.22674902
43CHEK21.20338803
44DYRK31.19210811
45ERBB41.11737562
46TGFBR11.11153668
47MST41.09807989
48CHEK11.08813820
49PAK41.08438206
50STK41.05279371
51STK101.04546783
52SCYL21.03776878
53BMPR1B1.03387719
54KDR1.02964359
55CDK40.97160141
56NME10.95970271
57WNK30.93816460
58LIMK10.89704078
59* EIF2AK10.88900978
60PDK40.86988932
61PDK30.86988932
62SIK30.86237359
63PIM10.85852741
64MAP3K110.85187800
65CSNK1G10.81720811
66FRK0.81217570
67ATM0.79723260
68MET0.79329839
69CSNK1G30.79221899
70CDK80.78767116
71CSNK2A10.78734179
72TNIK0.77025272
73STK38L0.76851489
74STK390.75664041
75CSNK2A20.74727318
76PAK10.73919358
77BRAF0.71397807
78CSNK1A1L0.70954227
79CDK20.68578328
80STK30.65033375
81PDK20.62883168
82PNCK0.62458342
83FLT30.60922020
84NEK90.60360207
85MAP4K10.59104701
86MAP4K20.56864468
87RPS6KA50.56425288
88DAPK10.55628846
89TXK0.55571237
90CSNK1G20.55253976
91CDK10.53884076
92MAPKAPK30.53273504
93IRAK30.51860290
94AKT30.50392455
95STK240.49407120
96MAP3K30.49355634
97MELK0.49351816
98FGFR10.48699870
99LRRK20.47561304
100PRKCI0.45718375
101MYLK0.44807609
102MAP2K30.43046245
103DYRK20.42151994
104ABL20.42032554
105BRD40.41883970
106MAPKAPK50.41492713
107ALK0.41284313
108CDK60.40990830
109ZAP700.40383706
110ERBB30.39844587
111LATS10.39514723
112ILK0.39247410
113TEC0.38241288
114CDK90.36873858
115* EIF2AK20.36685566
116CSNK1E0.35589805
117MINK10.34992653
118EEF2K0.34402694
119IRAK40.32807212
120FER0.31925918
121CDK120.31026900
122OXSR10.30531692
123IKBKB0.29435025
124AKT20.28801393
125JAK30.28480196
126CLK10.27759264
127BCR0.27745518
128YES10.27621221
129BTK0.27355046
130BCKDK0.26514748
131MARK30.26448648
132PRKDC0.25450270
133NUAK10.24688384

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61735517
2Proteasome_Homo sapiens_hsa030504.33724740
3Mismatch repair_Homo sapiens_hsa034303.96956650
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.86255500
5Ribosome_Homo sapiens_hsa030103.53744191
6RNA polymerase_Homo sapiens_hsa030203.47554019
7Spliceosome_Homo sapiens_hsa030403.19011696
8* RNA transport_Homo sapiens_hsa030133.02672917
9Homologous recombination_Homo sapiens_hsa034402.92300998
10Nucleotide excision repair_Homo sapiens_hsa034202.83043198
11Base excision repair_Homo sapiens_hsa034102.64464839
12Pyrimidine metabolism_Homo sapiens_hsa002402.54976571
13Cell cycle_Homo sapiens_hsa041102.53604470
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50741268
15One carbon pool by folate_Homo sapiens_hsa006702.46235365
16Non-homologous end-joining_Homo sapiens_hsa034502.03799189
17Fanconi anemia pathway_Homo sapiens_hsa034601.98713956
18Basal transcription factors_Homo sapiens_hsa030221.96912839
19RNA degradation_Homo sapiens_hsa030181.88358714
20Propanoate metabolism_Homo sapiens_hsa006401.71107549
21p53 signaling pathway_Homo sapiens_hsa041151.59790416
22Pyruvate metabolism_Homo sapiens_hsa006201.52971239
23Fatty acid elongation_Homo sapiens_hsa000621.44901557
24mRNA surveillance pathway_Homo sapiens_hsa030151.42635631
25Purine metabolism_Homo sapiens_hsa002301.39767597
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36018367
27Steroid biosynthesis_Homo sapiens_hsa001001.31929187
28Epstein-Barr virus infection_Homo sapiens_hsa051691.30959721
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25470886
30Protein export_Homo sapiens_hsa030601.20990484
31Sulfur metabolism_Homo sapiens_hsa009201.13533560
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12460515
33Systemic lupus erythematosus_Homo sapiens_hsa053221.10760516
34Antigen processing and presentation_Homo sapiens_hsa046121.00792942
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96615907
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.93052531
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90102727
38Legionellosis_Homo sapiens_hsa051340.89273969
39Huntingtons disease_Homo sapiens_hsa050160.88132228
40Parkinsons disease_Homo sapiens_hsa050120.87801012
41Viral carcinogenesis_Homo sapiens_hsa052030.86038383
42Vitamin B6 metabolism_Homo sapiens_hsa007500.85663659
43Pentose phosphate pathway_Homo sapiens_hsa000300.84528122
44* Herpes simplex infection_Homo sapiens_hsa051680.82430601
45Biosynthesis of amino acids_Homo sapiens_hsa012300.81629653
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81531135
47Folate biosynthesis_Homo sapiens_hsa007900.81093548
48Oocyte meiosis_Homo sapiens_hsa041140.77758242
49Oxidative phosphorylation_Homo sapiens_hsa001900.71842814
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67919055
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.63522752
52Selenocompound metabolism_Homo sapiens_hsa004500.62335874
53Glutathione metabolism_Homo sapiens_hsa004800.62226904
54HTLV-I infection_Homo sapiens_hsa051660.60272258
55Allograft rejection_Homo sapiens_hsa053300.59280426
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58205147
57Carbon metabolism_Homo sapiens_hsa012000.57777943
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57678838
59Butanoate metabolism_Homo sapiens_hsa006500.57631996
60Fatty acid metabolism_Homo sapiens_hsa012120.54319481
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.52130720
62Thyroid cancer_Homo sapiens_hsa052160.50850375
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50681046
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50319867
65Shigellosis_Homo sapiens_hsa051310.49913101
66Primary immunodeficiency_Homo sapiens_hsa053400.49127099
67Caffeine metabolism_Homo sapiens_hsa002320.48921950
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46309891
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44933135
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44669810
71Graft-versus-host disease_Homo sapiens_hsa053320.43663986
72Peroxisome_Homo sapiens_hsa041460.41711804
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.41023421
74Small cell lung cancer_Homo sapiens_hsa052220.38626506
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38370985
76* Measles_Homo sapiens_hsa051620.38347282
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38342785
78Asthma_Homo sapiens_hsa053100.37009025
79* Apoptosis_Homo sapiens_hsa042100.37008092
80Sulfur relay system_Homo sapiens_hsa041220.36863402
81* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36726992
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35043772
83Viral myocarditis_Homo sapiens_hsa054160.35025611
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33746894
85MicroRNAs in cancer_Homo sapiens_hsa052060.33680039
86Hematopoietic cell lineage_Homo sapiens_hsa046400.33394257
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.33054971
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32853826
89Fructose and mannose metabolism_Homo sapiens_hsa000510.32688431
90beta-Alanine metabolism_Homo sapiens_hsa004100.32426933
91Arginine and proline metabolism_Homo sapiens_hsa003300.32380483
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31410650
93Metabolic pathways_Homo sapiens_hsa011000.29004260
94N-Glycan biosynthesis_Homo sapiens_hsa005100.28776085
95Fatty acid degradation_Homo sapiens_hsa000710.28560002
96TGF-beta signaling pathway_Homo sapiens_hsa043500.28292680
97* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27778653
98Autoimmune thyroid disease_Homo sapiens_hsa053200.27582919
99Vibrio cholerae infection_Homo sapiens_hsa051100.26892655
100Type I diabetes mellitus_Homo sapiens_hsa049400.25437868
101Hepatitis B_Homo sapiens_hsa051610.24980915
102HIF-1 signaling pathway_Homo sapiens_hsa040660.24552658
103Cardiac muscle contraction_Homo sapiens_hsa042600.23720813
104Alcoholism_Homo sapiens_hsa050340.23677401
105Tryptophan metabolism_Homo sapiens_hsa003800.22689751
106Alzheimers disease_Homo sapiens_hsa050100.22454370
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22257487
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21297912
109Arachidonic acid metabolism_Homo sapiens_hsa005900.20936208
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20759161
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18931007
112Galactose metabolism_Homo sapiens_hsa000520.18796811
113Renin-angiotensin system_Homo sapiens_hsa046140.16972358
114* Influenza A_Homo sapiens_hsa051640.16927177
115Regulation of autophagy_Homo sapiens_hsa041400.16009022
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15740339
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15567105
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15173529
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14239188
120Collecting duct acid secretion_Homo sapiens_hsa049660.13760478
121Hippo signaling pathway_Homo sapiens_hsa043900.13733447
122Adherens junction_Homo sapiens_hsa045200.12558521
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12093482
124Colorectal cancer_Homo sapiens_hsa052100.11687055
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.11655548
126Lysine degradation_Homo sapiens_hsa003100.10035332
127Sphingolipid metabolism_Homo sapiens_hsa006000.09981254
128Tight junction_Homo sapiens_hsa045300.09711749
129Nitrogen metabolism_Homo sapiens_hsa009100.08186430
130Circadian rhythm_Homo sapiens_hsa047100.06481352
131Wnt signaling pathway_Homo sapiens_hsa043100.06244104
132Mineral absorption_Homo sapiens_hsa049780.05867907
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05232102

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