

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.93467148 |
| 2 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 5.36493445 |
| 3 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 5.36493445 |
| 4 | cytidine deamination (GO:0009972) | 5.09925233 |
| 5 | cytidine metabolic process (GO:0046087) | 5.09925233 |
| 6 | cytidine catabolic process (GO:0006216) | 5.09925233 |
| 7 | proteasome assembly (GO:0043248) | 4.88939493 |
| 8 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.53613366 |
| 9 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.39316469 |
| 10 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.17930098 |
| 11 | purine nucleotide salvage (GO:0032261) | 4.17693896 |
| 12 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.06838578 |
| 13 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.04133890 |
| 14 | ATP synthesis coupled proton transport (GO:0015986) | 4.04133890 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.94959529 |
| 16 | rRNA modification (GO:0000154) | 3.91963619 |
| 17 | protein-cofactor linkage (GO:0018065) | 3.89994501 |
| 18 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.86383391 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 3.86383391 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.86383391 |
| 21 | protein neddylation (GO:0045116) | 3.81997056 |
| 22 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.81282844 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.78325962 |
| 24 | protein complex biogenesis (GO:0070271) | 3.73870410 |
| 25 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.63154715 |
| 26 | rRNA methylation (GO:0031167) | 3.61228105 |
| 27 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.60580656 |
| 28 | pseudouridine synthesis (GO:0001522) | 3.59857830 |
| 29 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.55105113 |
| 30 | adenosine metabolic process (GO:0046085) | 3.54735450 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.54208254 |
| 32 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.49981648 |
| 33 | platelet dense granule organization (GO:0060155) | 3.44931654 |
| 34 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.43976935 |
| 35 | negative regulation of ligase activity (GO:0051352) | 3.43976935 |
| 36 | mitochondrial RNA metabolic process (GO:0000959) | 3.40823750 |
| 37 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.38598394 |
| 38 | ribosomal small subunit assembly (GO:0000028) | 3.38356652 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.38128562 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.38128562 |
| 41 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.37295762 |
| 42 | regulation of regulatory T cell differentiation (GO:0045589) | 3.35928120 |
| 43 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.35746227 |
| 44 | respiratory electron transport chain (GO:0022904) | 3.34951851 |
| 45 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.34458579 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.34458579 |
| 47 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.34458579 |
| 48 | CENP-A containing nucleosome assembly (GO:0034080) | 3.29631079 |
| 49 | electron transport chain (GO:0022900) | 3.29298719 |
| 50 | chaperone-mediated protein transport (GO:0072321) | 3.25929077 |
| 51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.24427198 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.17736668 |
| 53 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.15749338 |
| 54 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.15749338 |
| 55 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.14093038 |
| 56 | cullin deneddylation (GO:0010388) | 3.13999001 |
| 57 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.12007453 |
| 58 | response to interferon-beta (GO:0035456) | 3.09833156 |
| 59 | single strand break repair (GO:0000012) | 3.08758170 |
| 60 | positive regulation of ligase activity (GO:0051351) | 3.08488122 |
| 61 | regulation of chronic inflammatory response (GO:0002676) | 3.06805430 |
| 62 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.04809038 |
| 63 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.03624968 |
| 64 | termination of RNA polymerase III transcription (GO:0006386) | 3.03624968 |
| 65 | regulation of vitamin metabolic process (GO:0030656) | 3.03439487 |
| 66 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.00366219 |
| 67 | cellular response to interferon-beta (GO:0035458) | 3.00012350 |
| 68 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.98487873 |
| 69 | chromatin remodeling at centromere (GO:0031055) | 2.96809543 |
| 70 | homocysteine metabolic process (GO:0050667) | 2.92468415 |
| 71 | ribosome biogenesis (GO:0042254) | 2.89144456 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.88011016 |
| 73 | protein deneddylation (GO:0000338) | 2.87297514 |
| 74 | DNA ligation (GO:0006266) | 2.85082990 |
| 75 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.83175450 |
| 76 | maturation of 5.8S rRNA (GO:0000460) | 2.82997241 |
| 77 | cellular component biogenesis (GO:0044085) | 2.80754910 |
| 78 | maturation of SSU-rRNA (GO:0030490) | 2.79319487 |
| 79 | amino acid salvage (GO:0043102) | 2.79238651 |
| 80 | L-methionine salvage (GO:0071267) | 2.79238651 |
| 81 | L-methionine biosynthetic process (GO:0071265) | 2.79238651 |
| 82 | ribosomal large subunit biogenesis (GO:0042273) | 2.78425147 |
| 83 | ribosome assembly (GO:0042255) | 2.75478506 |
| 84 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.75157410 |
| 85 | positive regulation of cell cycle arrest (GO:0071158) | 2.74319139 |
| 86 | rRNA processing (GO:0006364) | 2.73897452 |
| 87 | IMP biosynthetic process (GO:0006188) | 2.73352348 |
| 88 | inner mitochondrial membrane organization (GO:0007007) | 2.72550116 |
| 89 | transcription from RNA polymerase I promoter (GO:0006360) | 2.68036562 |
| 90 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.67701111 |
| 91 | termination of RNA polymerase I transcription (GO:0006363) | 2.67138800 |
| 92 | rRNA metabolic process (GO:0016072) | 2.67022506 |
| 93 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.66746576 |
| 94 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.66737538 |
| 95 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.66461645 |
| 96 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.65809373 |
| 97 | translation (GO:0006412) | 2.63420390 |
| 98 | regulation of ligase activity (GO:0051340) | 2.62173636 |
| 99 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.61258069 |
| 100 | tetrahydrofolate metabolic process (GO:0046653) | 2.57899951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 6.01952604 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.60563460 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.37377502 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.29639047 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.98580805 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.37687681 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.16019800 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.96545095 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.80052130 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72231413 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.67797797 |
| 12 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.52782176 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.49306963 |
| 14 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.48508736 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.32385892 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.30720621 |
| 17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.26178825 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.15830643 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.14357053 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.12875828 |
| 21 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.07009232 |
| 22 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.89771270 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.89629466 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.77348507 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.71513730 |
| 26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.69867508 |
| 27 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.69116880 |
| 28 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.68569894 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.67578253 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.65306540 |
| 31 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.60996552 |
| 32 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.60804738 |
| 33 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.54788533 |
| 34 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.54071881 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53871173 |
| 36 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.51921625 |
| 37 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.50214679 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.41768038 |
| 39 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.41705817 |
| 40 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.41132685 |
| 41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.40205523 |
| 42 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.38707211 |
| 43 | MYB_26560356_Chip-Seq_TH2_Human | 1.38651952 |
| 44 | EWS_26573619_Chip-Seq_HEK293_Human | 1.38252178 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.35133739 |
| 46 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.34935538 |
| 47 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.34202340 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.32947093 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29181801 |
| 50 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.28989451 |
| 51 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.28821829 |
| 52 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.24722325 |
| 53 | GATA3_26560356_Chip-Seq_TH2_Human | 1.24418902 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.23278298 |
| 55 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.23103730 |
| 56 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22943810 |
| 57 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.16433491 |
| 58 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.15606037 |
| 59 | AR_20517297_ChIP-Seq_VCAP_Human | 1.14702575 |
| 60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.13636362 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.12725557 |
| 62 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.12584367 |
| 63 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.12584367 |
| 64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.12248536 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.11728422 |
| 66 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10758640 |
| 67 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.09043458 |
| 68 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.08761609 |
| 69 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.07682511 |
| 70 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06161976 |
| 71 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.05775622 |
| 72 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.05625554 |
| 73 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.03023287 |
| 74 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.03023287 |
| 75 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01930704 |
| 76 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.01699356 |
| 77 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.00442636 |
| 78 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00346744 |
| 79 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.99243548 |
| 80 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.98473368 |
| 81 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.97865012 |
| 82 | NCOR_22424771_ChIP-Seq_293T_Human | 0.97077238 |
| 83 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.96686151 |
| 84 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.95873432 |
| 85 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.95702982 |
| 86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95212297 |
| 87 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.94750407 |
| 88 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.94396731 |
| 89 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.94241899 |
| 90 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.94141522 |
| 91 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.94141522 |
| 92 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.93272559 |
| 93 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93155503 |
| 94 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.92494377 |
| 95 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92240996 |
| 96 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.91595771 |
| 97 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90333919 |
| 98 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88304666 |
| 99 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.87987159 |
| 100 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87507841 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002138_abnormal_hepatobiliary_system | 4.22246602 |
| 2 | MP0001873_stomach_inflammation | 3.52065998 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.40380715 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.14473765 |
| 5 | MP0005671_abnormal_response_to | 2.88508960 |
| 6 | MP0008058_abnormal_DNA_repair | 2.59698652 |
| 7 | MP0008995_early_reproductive_senescence | 2.56214979 |
| 8 | MP0003786_premature_aging | 2.51376742 |
| 9 | MP0004147_increased_porphyrin_level | 2.14220316 |
| 10 | MP0003186_abnormal_redox_activity | 2.13558821 |
| 11 | MP0005084_abnormal_gallbladder_morpholo | 2.12576253 |
| 12 | MP0005646_abnormal_pituitary_gland | 2.10998421 |
| 13 | MP0001919_abnormal_reproductive_system | 2.04864077 |
| 14 | MP0009785_altered_susceptibility_to | 2.04082578 |
| 15 | MP0009333_abnormal_splenocyte_physiolog | 2.03343562 |
| 16 | MP0002736_abnormal_nociception_after | 2.01941108 |
| 17 | MP0001764_abnormal_homeostasis | 1.96772647 |
| 18 | MP0001800_abnormal_humoral_immune | 1.93991611 |
| 19 | MP0005389_reproductive_system_phenotype | 1.93890541 |
| 20 | MP0002148_abnormal_hypersensitivity_rea | 1.91375565 |
| 21 | MP0005000_abnormal_immune_tolerance | 1.86318751 |
| 22 | MP0006072_abnormal_retinal_apoptosis | 1.75888286 |
| 23 | MP0008872_abnormal_physiological_respon | 1.75813868 |
| 24 | MP0001968_abnormal_touch/_nociception | 1.72869333 |
| 25 | MP0008007_abnormal_cellular_replicative | 1.64121571 |
| 26 | MP0005387_immune_system_phenotype | 1.60830835 |
| 27 | MP0001790_abnormal_immune_system | 1.60830835 |
| 28 | MP0002166_altered_tumor_susceptibility | 1.57810682 |
| 29 | MP0002723_abnormal_immune_serum | 1.56744673 |
| 30 | MP0002160_abnormal_reproductive_system | 1.53372638 |
| 31 | MP0002837_dystrophic_cardiac_calcinosis | 1.50275387 |
| 32 | MP0004957_abnormal_blastocyst_morpholog | 1.49562798 |
| 33 | MP0002006_tumorigenesis | 1.46234967 |
| 34 | MP0002420_abnormal_adaptive_immunity | 1.39810727 |
| 35 | MP0003252_abnormal_bile_duct | 1.36144383 |
| 36 | MP0001819_abnormal_immune_cell | 1.35941104 |
| 37 | MP0004885_abnormal_endolymph | 1.35343656 |
| 38 | MP0002452_abnormal_antigen_presenting | 1.34008270 |
| 39 | MP0003718_maternal_effect | 1.33875340 |
| 40 | MP0005075_abnormal_melanosome_morpholog | 1.29452846 |
| 41 | MP0002933_joint_inflammation | 1.27710671 |
| 42 | MP0003724_increased_susceptibility_to | 1.27324706 |
| 43 | MP0009379_abnormal_foot_pigmentation | 1.27132240 |
| 44 | MP0001986_abnormal_taste_sensitivity | 1.24837032 |
| 45 | MP0009764_decreased_sensitivity_to | 1.24648781 |
| 46 | MP0001853_heart_inflammation | 1.24038370 |
| 47 | MP0002876_abnormal_thyroid_physiology | 1.23495233 |
| 48 | MP0000703_abnormal_thymus_morphology | 1.20742687 |
| 49 | MP0002102_abnormal_ear_morphology | 1.20519281 |
| 50 | MP0002398_abnormal_bone_marrow | 1.17717565 |
| 51 | MP0008877_abnormal_DNA_methylation | 1.17208817 |
| 52 | MP0000716_abnormal_immune_system | 1.16581001 |
| 53 | MP0010094_abnormal_chromosome_stability | 1.15621909 |
| 54 | MP0005367_renal/urinary_system_phenotyp | 1.14754944 |
| 55 | MP0000516_abnormal_urinary_system | 1.14754944 |
| 56 | MP0006036_abnormal_mitochondrial_physio | 1.14272032 |
| 57 | MP0008057_abnormal_DNA_replication | 1.12683379 |
| 58 | MP0002405_respiratory_system_inflammati | 1.11413117 |
| 59 | MP0000689_abnormal_spleen_morphology | 1.11298872 |
| 60 | MP0008875_abnormal_xenobiotic_pharmacok | 1.11292342 |
| 61 | MP0003763_abnormal_thymus_physiology | 1.06933721 |
| 62 | MP0002722_abnormal_immune_system | 1.05474416 |
| 63 | MP0002429_abnormal_blood_cell | 1.01004946 |
| 64 | MP0000685_abnormal_immune_system | 1.00159254 |
| 65 | MP0002396_abnormal_hematopoietic_system | 0.99665209 |
| 66 | MP0001542_abnormal_bone_strength | 0.98431257 |
| 67 | MP0003315_abnormal_perineum_morphology | 0.98356710 |
| 68 | MP0004019_abnormal_vitamin_homeostasis | 0.98043027 |
| 69 | MP0004043_abnormal_pH_regulation | 0.93645641 |
| 70 | MP0006054_spinal_hemorrhage | 0.93199761 |
| 71 | MP0000013_abnormal_adipose_tissue | 0.91090653 |
| 72 | MP0002210_abnormal_sex_determination | 0.90392507 |
| 73 | MP0001845_abnormal_inflammatory_respons | 0.90274569 |
| 74 | MP0008469_abnormal_protein_level | 0.88955681 |
| 75 | MP0002295_abnormal_pulmonary_circulatio | 0.86296860 |
| 76 | MP0009765_abnormal_xenobiotic_induced | 0.85455632 |
| 77 | MP0005645_abnormal_hypothalamus_physiol | 0.85316125 |
| 78 | MP0005253_abnormal_eye_physiology | 0.85271902 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.84209089 |
| 80 | MP0000653_abnormal_sex_gland | 0.84176281 |
| 81 | MP0005025_abnormal_response_to | 0.83168881 |
| 82 | MP0001119_abnormal_female_reproductive | 0.82982711 |
| 83 | MP0004036_abnormal_muscle_relaxation | 0.82379135 |
| 84 | MP0000371_diluted_coat_color | 0.81968650 |
| 85 | MP0003011_delayed_dark_adaptation | 0.80802533 |
| 86 | MP0005551_abnormal_eye_electrophysiolog | 0.80295880 |
| 87 | MP0002277_abnormal_respiratory_mucosa | 0.78261997 |
| 88 | MP0001145_abnormal_male_reproductive | 0.77376217 |
| 89 | MP0003195_calcinosis | 0.75990597 |
| 90 | MP0001485_abnormal_pinna_reflex | 0.75166024 |
| 91 | MP0010155_abnormal_intestine_physiology | 0.73818183 |
| 92 | MP0002693_abnormal_pancreas_physiology | 0.73465752 |
| 93 | MP0000613_abnormal_salivary_gland | 0.73438407 |
| 94 | MP0005332_abnormal_amino_acid | 0.72076073 |
| 95 | MP0002638_abnormal_pupillary_reflex | 0.70103146 |
| 96 | MP0002234_abnormal_pharynx_morphology | 0.69742372 |
| 97 | MP0004145_abnormal_muscle_electrophysio | 0.69254541 |
| 98 | MP0009643_abnormal_urine_homeostasis | 0.68475851 |
| 99 | MP0002019_abnormal_tumor_incidence | 0.68208496 |
| 100 | MP0006035_abnormal_mitochondrial_morpho | 0.66453415 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.60138740 |
| 2 | Acute encephalopathy (HP:0006846) | 4.21238751 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.91941606 |
| 4 | Progressive macrocephaly (HP:0004481) | 3.84544489 |
| 5 | 3-Methylglutaconic aciduria (HP:0003535) | 3.80010148 |
| 6 | Abnormal number of erythroid precursors (HP:0012131) | 3.78348093 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.77482572 |
| 8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.59485027 |
| 9 | Abnormality of alanine metabolism (HP:0010916) | 3.59485027 |
| 10 | Hyperalaninemia (HP:0003348) | 3.59485027 |
| 11 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.54849210 |
| 12 | Aplastic anemia (HP:0001915) | 3.39444471 |
| 13 | Increased CSF lactate (HP:0002490) | 3.36148571 |
| 14 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.26341407 |
| 15 | Congenital, generalized hypertrichosis (HP:0004540) | 3.13644919 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.12025940 |
| 17 | Abnormality of the prostate (HP:0008775) | 3.00792774 |
| 18 | Type 2 muscle fiber atrophy (HP:0003554) | 3.00601976 |
| 19 | Cerebral edema (HP:0002181) | 2.99314191 |
| 20 | Constricted visual fields (HP:0001133) | 2.96115127 |
| 21 | Premature ovarian failure (HP:0008209) | 2.87883417 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.83834396 |
| 23 | Nausea (HP:0002018) | 2.82714555 |
| 24 | Abolished electroretinogram (ERG) (HP:0000550) | 2.82117079 |
| 25 | Hepatocellular necrosis (HP:0001404) | 2.76067221 |
| 26 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.74433375 |
| 27 | Abnormality of serum amino acid levels (HP:0003112) | 2.70861026 |
| 28 | Pendular nystagmus (HP:0012043) | 2.70020259 |
| 29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.65499544 |
| 30 | Muscle fiber atrophy (HP:0100295) | 2.63391602 |
| 31 | Increased serum lactate (HP:0002151) | 2.62678026 |
| 32 | Anorexia (HP:0002039) | 2.62482249 |
| 33 | Hepatic necrosis (HP:0002605) | 2.59270148 |
| 34 | Lethargy (HP:0001254) | 2.57813045 |
| 35 | Nonprogressive disorder (HP:0003680) | 2.57811942 |
| 36 | Lactic acidosis (HP:0003128) | 2.55347725 |
| 37 | Hyperglycinemia (HP:0002154) | 2.54551470 |
| 38 | IgG deficiency (HP:0004315) | 2.48329341 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.47407910 |
| 40 | Methylmalonic acidemia (HP:0002912) | 2.39589137 |
| 41 | Attenuation of retinal blood vessels (HP:0007843) | 2.38303663 |
| 42 | Congenital sensorineural hearing impairment (HP:0008527) | 2.35927910 |
| 43 | IgM deficiency (HP:0002850) | 2.34701960 |
| 44 | Congenital stationary night blindness (HP:0007642) | 2.28835164 |
| 45 | Metaphyseal dysplasia (HP:0100255) | 2.23432651 |
| 46 | Methylmalonic aciduria (HP:0012120) | 2.23291903 |
| 47 | Abnormality of DNA repair (HP:0003254) | 2.22744689 |
| 48 | Pancytopenia (HP:0001876) | 2.22248961 |
| 49 | Macrocytic anemia (HP:0001972) | 2.20167296 |
| 50 | Generalized aminoaciduria (HP:0002909) | 2.19852748 |
| 51 | Optic disc pallor (HP:0000543) | 2.18869597 |
| 52 | Exercise intolerance (HP:0003546) | 2.17531268 |
| 53 | Pulmonary embolism (HP:0002204) | 2.16890132 |
| 54 | Type II lissencephaly (HP:0007260) | 2.16834123 |
| 55 | Renal Fanconi syndrome (HP:0001994) | 2.12932905 |
| 56 | Autoimmune hemolytic anemia (HP:0001890) | 2.12630554 |
| 57 | Pulmonary fibrosis (HP:0002206) | 2.07668445 |
| 58 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.07100487 |
| 59 | Reticulocytopenia (HP:0001896) | 2.06481091 |
| 60 | Glycosuria (HP:0003076) | 2.06389904 |
| 61 | Abnormality of urine glucose concentration (HP:0011016) | 2.06389904 |
| 62 | Increased IgM level (HP:0003496) | 2.04570873 |
| 63 | Respiratory failure (HP:0002878) | 2.04144406 |
| 64 | Stomatitis (HP:0010280) | 2.00792315 |
| 65 | Chronic hepatic failure (HP:0100626) | 2.00535001 |
| 66 | Amniotic constriction ring (HP:0009775) | 1.98727945 |
| 67 | Abnormality of placental membranes (HP:0011409) | 1.98727945 |
| 68 | Metabolic acidosis (HP:0001942) | 1.98323292 |
| 69 | Increased corneal curvature (HP:0100692) | 1.98153273 |
| 70 | Keratoconus (HP:0000563) | 1.98153273 |
| 71 | Absent thumb (HP:0009777) | 1.95550471 |
| 72 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.95252302 |
| 73 | Abnormality of glycine metabolism (HP:0010895) | 1.95252302 |
| 74 | Abnormality of T cell physiology (HP:0011840) | 1.92540717 |
| 75 | Hyperphosphaturia (HP:0003109) | 1.89686600 |
| 76 | Ketoacidosis (HP:0001993) | 1.89573375 |
| 77 | Rib fusion (HP:0000902) | 1.86863933 |
| 78 | Increased intramyocellular lipid droplets (HP:0012240) | 1.86562694 |
| 79 | Oral leukoplakia (HP:0002745) | 1.85593708 |
| 80 | Pancreatic cysts (HP:0001737) | 1.83904695 |
| 81 | Abnormality of T cells (HP:0002843) | 1.83703436 |
| 82 | Exertional dyspnea (HP:0002875) | 1.82139802 |
| 83 | Dicarboxylic aciduria (HP:0003215) | 1.82024680 |
| 84 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.82024680 |
| 85 | Severe combined immunodeficiency (HP:0004430) | 1.81133790 |
| 86 | Hyperglycinuria (HP:0003108) | 1.80924775 |
| 87 | Homocystinuria (HP:0002156) | 1.79691561 |
| 88 | Abnormality of homocysteine metabolism (HP:0010919) | 1.79691561 |
| 89 | Dry hair (HP:0011359) | 1.77198476 |
| 90 | Prostate neoplasm (HP:0100787) | 1.76812643 |
| 91 | Severe visual impairment (HP:0001141) | 1.76653696 |
| 92 | Chronic sinusitis (HP:0011109) | 1.76229576 |
| 93 | Thyroiditis (HP:0100646) | 1.76160187 |
| 94 | Neutropenia (HP:0001875) | 1.75880757 |
| 95 | Type I transferrin isoform profile (HP:0003642) | 1.75612201 |
| 96 | Poor suck (HP:0002033) | 1.75005589 |
| 97 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.73398129 |
| 98 | Cerebral hypomyelination (HP:0006808) | 1.72809912 |
| 99 | Vasculitis (HP:0002633) | 1.71195750 |
| 100 | Birth length less than 3rd percentile (HP:0003561) | 1.70614679 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.45708083 |
| 2 | VRK2 | 4.46111042 |
| 3 | TSSK6 | 3.56168234 |
| 4 | MST4 | 3.50385339 |
| 5 | EIF2AK3 | 3.35435456 |
| 6 | STK16 | 2.92288274 |
| 7 | CDK19 | 2.62219623 |
| 8 | TLK1 | 2.57978810 |
| 9 | KDR | 2.41939069 |
| 10 | BMPR1B | 2.30008371 |
| 11 | NUAK1 | 2.25864643 |
| 12 | EIF2AK1 | 2.23110466 |
| 13 | TAOK3 | 2.18901638 |
| 14 | VRK1 | 2.03895981 |
| 15 | OXSR1 | 1.95642778 |
| 16 | STK39 | 1.90649448 |
| 17 | NEK1 | 1.67045936 |
| 18 | BUB1 | 1.62958669 |
| 19 | GRK1 | 1.59573314 |
| 20 | FRK | 1.55888713 |
| 21 | RPS6KB2 | 1.54957913 |
| 22 | SCYL2 | 1.54698171 |
| 23 | ADRBK2 | 1.52417544 |
| 24 | MAP4K1 | 1.39723225 |
| 25 | EIF2AK2 | 1.36686214 |
| 26 | WNK4 | 1.26667026 |
| 27 | PLK3 | 1.26116956 |
| 28 | TAF1 | 1.21399134 |
| 29 | NME1 | 1.15333634 |
| 30 | KIT | 1.05488619 |
| 31 | MAPKAPK5 | 1.02035273 |
| 32 | ACVR1B | 1.01156648 |
| 33 | PBK | 1.00957250 |
| 34 | PINK1 | 0.98200136 |
| 35 | IKBKB | 0.96878211 |
| 36 | SYK | 0.96664592 |
| 37 | CDK9 | 0.93026712 |
| 38 | TEC | 0.91594041 |
| 39 | TRIM28 | 0.89555858 |
| 40 | IKBKE | 0.88352901 |
| 41 | ITK | 0.85375120 |
| 42 | TIE1 | 0.83004406 |
| 43 | JAK3 | 0.81078901 |
| 44 | PHKG2 | 0.79070199 |
| 45 | PHKG1 | 0.79070199 |
| 46 | MKNK2 | 0.75678438 |
| 47 | STK38L | 0.67183557 |
| 48 | MKNK1 | 0.64442868 |
| 49 | NME2 | 0.64114085 |
| 50 | CDC7 | 0.61365330 |
| 51 | BTK | 0.59182128 |
| 52 | CSNK2A1 | 0.59051159 |
| 53 | PLK2 | 0.58848686 |
| 54 | PRKCQ | 0.57932781 |
| 55 | BCKDK | 0.57004627 |
| 56 | SRPK1 | 0.56363441 |
| 57 | MAPKAPK3 | 0.55582484 |
| 58 | MAP3K12 | 0.55137055 |
| 59 | ADRBK1 | 0.54237619 |
| 60 | CSNK2A2 | 0.52814142 |
| 61 | PLK1 | 0.51489109 |
| 62 | DYRK2 | 0.50918730 |
| 63 | TESK2 | 0.47531150 |
| 64 | OBSCN | 0.46118732 |
| 65 | RPS6KA5 | 0.45177216 |
| 66 | MAP3K11 | 0.44417321 |
| 67 | ABL2 | 0.43884499 |
| 68 | MYLK | 0.43854970 |
| 69 | WNK1 | 0.43434817 |
| 70 | INSRR | 0.41492534 |
| 71 | MAP3K3 | 0.41266969 |
| 72 | LYN | 0.41189109 |
| 73 | ZAK | 0.40504671 |
| 74 | ERBB3 | 0.39568125 |
| 75 | ABL1 | 0.38550357 |
| 76 | PAK4 | 0.38472795 |
| 77 | LCK | 0.38350574 |
| 78 | PDK2 | 0.37669028 |
| 79 | AURKA | 0.37590608 |
| 80 | ATR | 0.36736672 |
| 81 | STK24 | 0.36185943 |
| 82 | MAPK15 | 0.35678697 |
| 83 | CSNK1A1 | 0.34353471 |
| 84 | IRAK4 | 0.30943159 |
| 85 | IGF1R | 0.30498313 |
| 86 | BMPR2 | 0.29744043 |
| 87 | STK3 | 0.29398115 |
| 88 | CSNK1G3 | 0.28876043 |
| 89 | PRKCA | 0.28141115 |
| 90 | AURKB | 0.27814661 |
| 91 | PRKCE | 0.27403796 |
| 92 | GRK6 | 0.27273965 |
| 93 | PRKCD | 0.27127541 |
| 94 | PLK4 | 0.26929748 |
| 95 | CDK8 | 0.26856785 |
| 96 | PRKCI | 0.25846082 |
| 97 | AKT3 | 0.24678678 |
| 98 | PRKACA | 0.24073960 |
| 99 | PRKCG | 0.23049913 |
| 100 | ALK | 0.22939150 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.10989368 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.33750257 |
| 3 | Asthma_Homo sapiens_hsa05310 | 3.03702878 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 2.82638665 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.77933018 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.76180751 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.71984281 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.70552841 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.62705911 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.40534563 |
| 11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.26963892 |
| 12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.21910787 |
| 13 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.17082117 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.12424213 |
| 15 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.01453270 |
| 16 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.92962838 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.79198413 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.78740104 |
| 19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.77321702 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.74502305 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.73441164 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.68782951 |
| 23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.62539844 |
| 24 | Spliceosome_Homo sapiens_hsa03040 | 1.61009370 |
| 25 | Basal transcription factors_Homo sapiens_hsa03022 | 1.60013523 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.57774770 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.47612057 |
| 28 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.45491647 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.40894707 |
| 30 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36355914 |
| 31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.30282128 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.16970525 |
| 33 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.09464643 |
| 34 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.07196407 |
| 35 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.06412932 |
| 36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.04906709 |
| 37 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.01365455 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.01342081 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 0.96317673 |
| 40 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.96082979 |
| 41 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.95425062 |
| 42 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.94177201 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 0.92180460 |
| 44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.91657398 |
| 45 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.89226922 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.86469671 |
| 47 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.84140121 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83832400 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.83622682 |
| 50 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.82714876 |
| 51 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.82335488 |
| 52 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.80184030 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 0.79953154 |
| 54 | Olfactory transduction_Homo sapiens_hsa04740 | 0.78695898 |
| 55 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.78104069 |
| 56 | Viral myocarditis_Homo sapiens_hsa05416 | 0.77716494 |
| 57 | Peroxisome_Homo sapiens_hsa04146 | 0.73801051 |
| 58 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.72557134 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.70294162 |
| 60 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.69877960 |
| 61 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.67443044 |
| 62 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.65684832 |
| 63 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.63733979 |
| 64 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.63020324 |
| 65 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.61486615 |
| 66 | Measles_Homo sapiens_hsa05162 | 0.58117496 |
| 67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.57123868 |
| 68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.54631210 |
| 69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54610105 |
| 70 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53749351 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.52741175 |
| 72 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.52705823 |
| 73 | Leishmaniasis_Homo sapiens_hsa05140 | 0.51497664 |
| 74 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.51350945 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.51299838 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48142557 |
| 77 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.47727326 |
| 78 | Base excision repair_Homo sapiens_hsa03410 | 0.46159216 |
| 79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45567013 |
| 80 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.43688773 |
| 81 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43012811 |
| 82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41812186 |
| 83 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.34719177 |
| 84 | Legionellosis_Homo sapiens_hsa05134 | 0.34150339 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.33817080 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.33019328 |
| 87 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.32053981 |
| 88 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.28739276 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.28561170 |
| 90 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.27572819 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24278488 |
| 92 | Morphine addiction_Homo sapiens_hsa05032 | 0.24092116 |
| 93 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.22981948 |
| 94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.22740637 |
| 95 | Malaria_Homo sapiens_hsa05144 | 0.22671359 |
| 96 | HTLV-I infection_Homo sapiens_hsa05166 | 0.20858485 |
| 97 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.20259468 |
| 98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18893973 |
| 99 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18831897 |
| 100 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.18693683 |

