ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	interleukin-6-mediated signaling pathway (GO:0070102)	7.66740830
2	galactose catabolic process (GO:0019388)	7.56640474
3	vitamin catabolic process (GO:0009111)	6.18762508
4	fat-soluble vitamin catabolic process (GO:0042363)	6.18762508
5	ribosomal large subunit biogenesis (GO:0042273)	5.79405648
6	regulation of translational termination (GO:0006449)	5.42661329
7	protein-cofactor linkage (GO:0018065)	4.93366868
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.78002234
9	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.72992610
10	CENP-A containing nucleosome assembly (GO:0034080)	4.69740824
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.68623967
12	ATP synthesis coupled proton transport (GO:0015986)	4.68623967
13	DNA replication checkpoint (GO:0000076)	4.63511706
14	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.58078387
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.56176175
16	chromatin remodeling at centromere (GO:0031055)	4.48889793
17	trivalent inorganic anion homeostasis (GO:0072506)	4.46788627
18	phosphate ion homeostasis (GO:0055062)	4.46788627
19	galactose metabolic process (GO:0006012)	4.31100805
20	histone exchange (GO:0043486)	4.27272988
21	regulation of DNA endoreduplication (GO:0032875)	4.24733298
22	cellular response to interleukin-6 (GO:0071354)	4.00986188
23	cellular anion homeostasis (GO:0030002)	3.92786182
24	telomere maintenance via telomerase (GO:0007004)	3.84296175
25	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.78612955
26	aldehyde catabolic process (GO:0046185)	3.71597440
27	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.67894474
28	regulation of mitotic spindle checkpoint (GO:1903504)	3.67894474
29	vitamin D metabolic process (GO:0042359)	3.67123204
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.54531855
31	organelle disassembly (GO:1903008)	3.42993607
32	DNA replication-independent nucleosome organization (GO:0034724)	3.40903086
33	DNA replication-independent nucleosome assembly (GO:0006336)	3.40903086
34	folic acid transport (GO:0015884)	3.35778502
35	chaperone-mediated protein transport (GO:0072321)	3.33451364
36	viral mRNA export from host cell nucleus (GO:0046784)	3.32869266
37	termination of RNA polymerase III transcription (GO:0006386)	3.28895973
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.28895973
39	centriole replication (GO:0007099)	3.28090268
40	response to interleukin-6 (GO:0070741)	3.27509285
41	maturation of SSU-rRNA (GO:0030490)	3.24063534
42	regulation of translational elongation (GO:0006448)	3.23987861
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23569435
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23569435
45	NADH dehydrogenase complex assembly (GO:0010257)	3.23569435
46	inner mitochondrial membrane organization (GO:0007007)	3.23320900
47	rRNA modification (GO:0000154)	3.22381248
48	respiratory electron transport chain (GO:0022904)	3.20528624
49	kinetochore organization (GO:0051383)	3.20137508
50	electron transport chain (GO:0022900)	3.15015887
51	maturation of 5.8S rRNA (GO:0000460)	3.14485984
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13422953
53	rRNA methylation (GO:0031167)	3.11597112
54	protein complex biogenesis (GO:0070271)	3.10800206
55	water-soluble vitamin biosynthetic process (GO:0042364)	3.10693532
56	mitotic G2/M transition checkpoint (GO:0044818)	3.10041271
57	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08957633
58	regulation of mesoderm development (GO:2000380)	3.08097435
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.05631192
60	ribonucleoprotein complex biogenesis (GO:0022613)	3.03741055
61	ncRNA catabolic process (GO:0034661)	3.03575457
62	regulation of posttranscriptional gene silencing (GO:0060147)	3.02525936
63	regulation of gene silencing by miRNA (GO:0060964)	3.02525936
64	regulation of gene silencing by RNA (GO:0060966)	3.02525936
65	response to redox state (GO:0051775)	3.00652560
66	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.99281734
67	proteasome assembly (GO:0043248)	2.98967705
68	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.93626873
69	isotype switching (GO:0045190)	2.93626873
70	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.93626873
71	protein neddylation (GO:0045116)	2.92203072
72	negative regulation of gene silencing (GO:0060969)	2.92072019
73	rRNA processing (GO:0006364)	2.91429334
74	DNA catabolic process, exonucleolytic (GO:0000738)	2.90757358
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89801403
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89801403
77	response to nitrosative stress (GO:0051409)	2.88681965
78	primary alcohol catabolic process (GO:0034310)	2.88323666
79	rRNA metabolic process (GO:0016072)	2.87118528
80	cellular component biogenesis (GO:0044085)	2.86786112
81	folic acid metabolic process (GO:0046655)	2.85950445
82	DNA deamination (GO:0045006)	2.85875569
83	RNA-dependent DNA replication (GO:0006278)	2.84896925
84	telomere maintenance via semi-conservative replication (GO:0032201)	2.83191474
85	keratinocyte development (GO:0003334)	2.81774035
86	regulation of centriole replication (GO:0046599)	2.80282367
87	pseudouridine synthesis (GO:0001522)	2.76665764
88	mitotic metaphase plate congression (GO:0007080)	2.74475773
89	telomere maintenance via recombination (GO:0000722)	2.74383073
90	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	2.74174775
91	tRNA metabolic process (GO:0006399)	2.73758829
92	single strand break repair (GO:0000012)	2.73563786
93	mitotic recombination (GO:0006312)	2.73524958
94	7-methylguanosine mRNA capping (GO:0006370)	2.72796240
95	mitotic sister chromatid cohesion (GO:0007064)	2.70579457
96	DNA double-strand break processing (GO:0000729)	2.70570623
97	tRNA aminoacylation (GO:0043039)	2.70295735
98	amino acid activation (GO:0043038)	2.70295735
99	mitotic G2 DNA damage checkpoint (GO:0007095)	2.69618386
100	telomere maintenance via telomere lengthening (GO:0010833)	2.69013568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26366535
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.19811874
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.02295747
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.48547424
5	VDR_22108803_ChIP-Seq_LS180_Human	3.16497422
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.14192977
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.02022414
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.88102250
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.75804129
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.65791588
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.62255882
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61949224
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58208661
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.46948679
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.40408228
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31429223
17	EWS_26573619_Chip-Seq_HEK293_Human	2.24920849
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.18361421
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16639327
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.12936662
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.11810992
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09152628
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06009603
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97633765
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.91368743
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.91138507
27	FUS_26573619_Chip-Seq_HEK293_Human	1.88220497
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87855467
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.86167550
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.80810581
31	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.80195234
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74787932
33	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.73849914
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.64363109
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61051860
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57946162
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.56278342
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52946753
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.52787226
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.49711066
41	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.48705370
42	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.46498306
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.45920298
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45258415
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44117673
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40718984
47	P300_19829295_ChIP-Seq_ESCs_Human	1.40477637
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40262603
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40262603
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39926700
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36695494
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.36177012
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.36122407
54	AR_21909140_ChIP-Seq_LNCAP_Human	1.33035411
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.32375616
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32046933
57	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.31798245
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31019756
59	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.24112721
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23936905
61	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.22523449
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21920955
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.21898381
64	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.20875898
65	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.18273406
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.15468067
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14704860
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14676945
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14636702
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14443568
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.14246774
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12429627
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.12429627
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09709280
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09709280
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.09331420
77	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.07296597
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04432344
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04394009
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00205325
81	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99027931
82	ELF5_23300383_ChIP-Seq_T47D_Human	0.98778841
83	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98620229
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98620229
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97762643
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.95659135
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95279562
88	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.95137239
89	AR_20517297_ChIP-Seq_VCAP_Human	0.94798796
90	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.93716327
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89803028
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.89651824
93	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.89624815
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89045606
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88387605
96	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.87544550
97	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.87544550
98	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.87544550
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85446437
100	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.84784467

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	3.48277930
2	MP0004043_abnormal_pH_regulation	3.06694462
3	MP0008877_abnormal_DNA_methylation	3.06027049
4	MP0001764_abnormal_homeostasis	3.02341433
5	MP0002736_abnormal_nociception_after	2.95481522
6	MP0002234_abnormal_pharynx_morphology	2.91133854
7	MP0006292_abnormal_olfactory_placode	2.71808932
8	MP0001542_abnormal_bone_strength	2.70662588
9	MP0004957_abnormal_blastocyst_morpholog	2.65401821
10	MP0003693_abnormal_embryo_hatching	2.63979727
11	MP0003315_abnormal_perineum_morphology	2.63147296
12	MP0002160_abnormal_reproductive_system	2.53610754
13	MP0002396_abnormal_hematopoietic_system	2.45446861
14	MP0002837_dystrophic_cardiac_calcinosis	2.44493501
15	MP0006072_abnormal_retinal_apoptosis	2.42182270
16	MP0005389_reproductive_system_phenotype	2.31965920
17	MP0009379_abnormal_foot_pigmentation	2.30123574
18	MP0008057_abnormal_DNA_replication	2.28370018
19	MP0005646_abnormal_pituitary_gland	2.28132729
20	MP0010094_abnormal_chromosome_stability	2.27460485
21	MP0004019_abnormal_vitamin_homeostasis	2.18640515
22	MP0003567_abnormal_fetal_cardiomyocyte	2.07336505
23	MP0008058_abnormal_DNA_repair	2.03619980
24	MP0003941_abnormal_skin_development	1.99583760
25	MP0001968_abnormal_touch/_nociception	1.98719291
26	MP0001188_hyperpigmentation	1.87862009
27	MP0002877_abnormal_melanocyte_morpholog	1.79879750
28	MP0000569_abnormal_digit_pigmentation	1.74161489
29	MP0001293_anophthalmia	1.74147735
30	MP0003195_calcinosis	1.66327118
31	MP0008961_abnormal_basal_metabolism	1.64461167
32	MP0008007_abnormal_cellular_replicative	1.62304519
33	MP0003890_abnormal_embryonic-extraembry	1.59288527
34	MP0003937_abnormal_limbs/digits/tail_de	1.56098246
35	MP0003111_abnormal_nucleus_morphology	1.54186917
36	MP0009053_abnormal_anal_canal	1.53886356
37	MP0002089_abnormal_postnatal_growth/wei	1.53437604
38	MP0002938_white_spotting	1.52534063
39	MP0001919_abnormal_reproductive_system	1.50474422
40	MP0001529_abnormal_vocalization	1.39455073
41	MP0003787_abnormal_imprinting	1.38354112
42	MP0004885_abnormal_endolymph	1.37882926
43	MP0004133_heterotaxia	1.31877338
44	MP0003806_abnormal_nucleotide_metabolis	1.29967734
45	MP0004142_abnormal_muscle_tone	1.28724772
46	MP0003718_maternal_effect	1.28400975
47	MP0006036_abnormal_mitochondrial_physio	1.28309095
48	MP0008932_abnormal_embryonic_tissue	1.28112031
49	MP0002102_abnormal_ear_morphology	1.20987228
50	MP0008875_abnormal_xenobiotic_pharmacok	1.19060349
51	MP0003077_abnormal_cell_cycle	1.15706895
52	MP0001485_abnormal_pinna_reflex	1.13492800
53	MP0002751_abnormal_autonomic_nervous	1.11108945
54	MP0002909_abnormal_adrenal_gland	1.10782796
55	MP0000631_abnormal_neuroendocrine_gland	1.09341016
56	MP0002272_abnormal_nervous_system	1.03750363
57	MP0003121_genomic_imprinting	1.03532022
58	MP0002177_abnormal_outer_ear	0.98084039
59	MP0006035_abnormal_mitochondrial_morpho	0.95755020
60	MP0003011_delayed_dark_adaptation	0.94902843
61	MP0004742_abnormal_vestibular_system	0.94856705
62	MP0009046_muscle_twitch	0.90073104
63	MP0003786_premature_aging	0.87969691
64	MP0005376_homeostasis/metabolism_phenot	0.87347896
65	MP0002084_abnormal_developmental_patter	0.85186196
66	MP0005187_abnormal_penis_morphology	0.84659322
67	MP0008872_abnormal_physiological_respon	0.84438808
68	MP0009697_abnormal_copulation	0.84266893
69	MP0009780_abnormal_chondrocyte_physiolo	0.79824733
70	MP0002876_abnormal_thyroid_physiology	0.79290472
71	MP0003119_abnormal_digestive_system	0.78175216
72	MP0004197_abnormal_fetal_growth/weight/	0.77933875
73	MP0000049_abnormal_middle_ear	0.75754169
74	MP0002210_abnormal_sex_determination	0.75310913
75	MP0005551_abnormal_eye_electrophysiolog	0.74826259
76	MP0001286_abnormal_eye_development	0.74411696
77	MP0004147_increased_porphyrin_level	0.74198065
78	MP0008789_abnormal_olfactory_epithelium	0.73677020
79	MP0001697_abnormal_embryo_size	0.71779460
80	MP0001177_atelectasis	0.71733631
81	MP0009250_abnormal_appendicular_skeleto	0.71635774
82	MP0004215_abnormal_myocardial_fiber	0.70247802
83	MP0001145_abnormal_male_reproductive	0.70003413
84	MP0005253_abnormal_eye_physiology	0.67282810
85	MP0003646_muscle_fatigue	0.65947621
86	MP0003938_abnormal_ear_development	0.65132207
87	MP0000350_abnormal_cell_proliferation	0.64391894
88	MP0005266_abnormal_metabolism	0.63561439
89	MP0001984_abnormal_olfaction	0.63255175
90	MP0002277_abnormal_respiratory_mucosa	0.61850018
91	MP0005636_abnormal_mineral_homeostasis	0.61158645
92	MP0002233_abnormal_nose_morphology	0.61064486
93	MP0001727_abnormal_embryo_implantation	0.60424612
94	MP0000653_abnormal_sex_gland	0.60374175
95	MP0000762_abnormal_tongue_morphology	0.59317810
96	MP0001765_abnormal_ion_homeostasis	0.58027073
97	MP0005332_abnormal_amino_acid	0.57652402
98	MP0002085_abnormal_embryonic_tissue	0.55888524
99	MP0001929_abnormal_gametogenesis	0.55546172
100	MP0010386_abnormal_urinary_bladder	0.55199672

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	9.04043400
2	Osteomalacia (HP:0002749)	5.84838208
3	Abnormality of renal resorption (HP:0011038)	5.11874786
4	Premature ovarian failure (HP:0008209)	4.82878324
5	Vascular calcification (HP:0004934)	4.62162258
6	Abnormal number of erythroid precursors (HP:0012131)	4.26371864
7	Acute necrotizing encephalopathy (HP:0006965)	4.12551173
8	Cardiovascular calcification (HP:0011915)	4.08096031
9	Volvulus (HP:0002580)	3.93219351
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.91012764
11	Congenital, generalized hypertrichosis (HP:0004540)	3.78045063
12	Acute encephalopathy (HP:0006846)	3.56728566
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.46394087
14	Progressive macrocephaly (HP:0004481)	3.44944583
15	Hyperphosphatemia (HP:0002905)	3.36905778
16	Increased hepatocellular lipid droplets (HP:0006565)	3.34868881
17	Mitochondrial inheritance (HP:0001427)	3.27181760
18	Chromsome breakage (HP:0040012)	3.22030800
19	Hypergonadotropic hypogonadism (HP:0000815)	3.17901479
20	Increased CSF lactate (HP:0002490)	2.99974764
21	Lipid accumulation in hepatocytes (HP:0006561)	2.94228856
22	Macrocytic anemia (HP:0001972)	2.93745270
23	Abnormal urine phosphate concentration (HP:0012599)	2.88061462
24	Sensory axonal neuropathy (HP:0003390)	2.80300527
25	Cerebral edema (HP:0002181)	2.75150077
26	Abnormality of midbrain morphology (HP:0002418)	2.64130930
27	Molar tooth sign on MRI (HP:0002419)	2.64130930
28	Methylmalonic acidemia (HP:0002912)	2.58186487
29	Aplastic anemia (HP:0001915)	2.51128046
30	Abnormality of chromosome stability (HP:0003220)	2.50531615
31	3-Methylglutaconic aciduria (HP:0003535)	2.49086326
32	Chronic bronchitis (HP:0004469)	2.48907274
33	Birth length less than 3rd percentile (HP:0003561)	2.48078933
34	Type I transferrin isoform profile (HP:0003642)	2.41989264
35	Abnormality of alanine metabolism (HP:0010916)	2.40032184
36	Hyperalaninemia (HP:0003348)	2.40032184
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40032184
38	Abnormality of renal excretion (HP:0011036)	2.38148521
39	Renal Fanconi syndrome (HP:0001994)	2.36805683
40	Abnormality of the labia minora (HP:0012880)	2.36046473
41	Small hand (HP:0200055)	2.35577304
42	Hypoplasia of the pons (HP:0012110)	2.35505702
43	Abnormality of the pons (HP:0007361)	2.31836941
44	Hepatocellular necrosis (HP:0001404)	2.24370722
45	Exertional dyspnea (HP:0002875)	2.21888080
46	Multiple enchondromatosis (HP:0005701)	2.20728130
47	Leukodystrophy (HP:0002415)	2.20696041
48	Pallor (HP:0000980)	2.19983441
49	Nephronophthisis (HP:0000090)	2.17748728
50	Metabolic acidosis (HP:0001942)	2.14960616
51	Abnormality of the dental pulp (HP:0006479)	2.14144890
52	Abnormality of serum amino acid levels (HP:0003112)	2.09859358
53	Pancreatic fibrosis (HP:0100732)	2.01729687
54	Hepatic necrosis (HP:0002605)	1.99181785
55	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98500708
56	Rickets (HP:0002748)	1.97115704
57	Pancreatic cysts (HP:0001737)	1.95079372
58	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.91931481
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.88736493
60	Lactic acidosis (HP:0003128)	1.86776027
61	Hyperglycinemia (HP:0002154)	1.85069844
62	Septo-optic dysplasia (HP:0100842)	1.83569171
63	Meckel diverticulum (HP:0002245)	1.83354207
64	Abolished electroretinogram (ERG) (HP:0000550)	1.81169204
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.79007689
66	Abnormality of the middle phalanges of the toes (HP:0010183)	1.78894606
67	Chondrocalcinosis (HP:0000934)	1.78892604
68	Increased serum lactate (HP:0002151)	1.78592283
69	Abnormality of the ileum (HP:0001549)	1.78447277
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78150694
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.78150694
72	Abnormal protein glycosylation (HP:0012346)	1.78150694
73	Abnormal glycosylation (HP:0012345)	1.78150694
74	Increased intramyocellular lipid droplets (HP:0012240)	1.76632773
75	Optic disc pallor (HP:0000543)	1.74926930
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73185914
77	Reduced antithrombin III activity (HP:0001976)	1.72098202
78	Abnormality of methionine metabolism (HP:0010901)	1.71427702
79	Respiratory failure (HP:0002878)	1.71019445
80	Abnormality of Sharpey fibers (HP:0100685)	1.69309557
81	Thyroid-stimulating hormone excess (HP:0002925)	1.69162202
82	Abnormality of the renal medulla (HP:0100957)	1.69062306
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.68991810
84	Renal cortical cysts (HP:0000803)	1.67178616
85	Methylmalonic aciduria (HP:0012120)	1.66259446
86	Colon cancer (HP:0003003)	1.65617275
87	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.65475535
88	Stenosis of the external auditory canal (HP:0000402)	1.63672487
89	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.63235458
90	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.63235458
91	Exercise intolerance (HP:0003546)	1.61389822
92	True hermaphroditism (HP:0010459)	1.60735062
93	Sclerocornea (HP:0000647)	1.60558127
94	Lethargy (HP:0001254)	1.58869459
95	Abnormality of the dental root (HP:0006486)	1.58361326
96	Taurodontia (HP:0000679)	1.58361326
97	Abnormality of permanent molar morphology (HP:0011071)	1.58361326
98	Absent/shortened dynein arms (HP:0200106)	1.57806543
99	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.57806543
100	Glycosuria (HP:0003076)	1.57097490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.19417737
2	MST4	4.03825417
3	TLK1	3.28430456
4	TAF1	2.78530811
5	PLK4	2.69765822
6	ZAK	2.51499727
7	PLK3	2.27818958
8	TNIK	2.22340081
9	NUAK1	2.18143577
10	STK16	2.11367222
11	BUB1	2.01900137
12	EIF2AK3	1.87891428
13	BMPR1B	1.82687290
14	VRK1	1.80450555
15	TRIM28	1.75184522
16	VRK2	1.70965439
17	WNK3	1.68592002
18	TTK	1.67025544
19	CDK19	1.66173513
20	MKNK2	1.61699211
21	EIF2AK1	1.60330124
22	PLK2	1.58919967
23	NTRK2	1.54159346
24	TSSK6	1.42595638
25	GRK1	1.42412135
26	NEK1	1.42332022
27	PLK1	1.38098180
28	OXSR1	1.34567256
29	MKNK1	1.30912047
30	FRK	1.24742324
31	MAPKAPK5	1.23804499
32	PNCK	1.17648605
33	ALK	1.11700469
34	EIF2AK2	1.10825480
35	MAP3K4	1.10316737
36	STK3	1.05548895
37	WEE1	1.01526132
38	MAP4K2	0.99836788
39	CHEK2	0.99053745
40	AURKB	0.97478260
41	NEK2	0.95555168
42	BRSK2	0.95183422
43	ACVR1B	0.93990814
44	PINK1	0.91886502
45	SRPK1	0.91484220
46	PHKG2	0.90586699
47	PHKG1	0.90586699
48	ADRBK2	0.90101884
49	INSRR	0.89459361
50	MAP2K7	0.88240785
51	WNK4	0.87012359
52	BMPR2	0.84287295
53	TIE1	0.81624718
54	MYLK	0.79917736
55	TAOK3	0.79833455
56	ABL2	0.78306129
57	STK24	0.76656435
58	STK39	0.76518915
59	CASK	0.76209571
60	DYRK2	0.75139855
61	TEC	0.74108818
62	CSNK2A1	0.73038797
63	MAP3K12	0.68853572
64	CSNK2A2	0.68846781
65	CSNK1E	0.66093326
66	MAPKAPK3	0.65033796
67	ATR	0.63969697
68	CSNK1G2	0.63010217
69	STK38L	0.62749812
70	EPHB2	0.60493016
71	PRKCG	0.60096441
72	ATM	0.59367835
73	CHEK1	0.59108359
74	CDK7	0.58344433
75	RPS6KB2	0.58334519
76	DMPK	0.57554898
77	DYRK3	0.56792837
78	TXK	0.56425314
79	CDK12	0.55252853
80	BCKDK	0.52880355
81	CDK8	0.51712069
82	AURKA	0.51605593
83	TGFBR1	0.51208995
84	SGK2	0.49604372
85	ERBB4	0.48828156
86	PAK3	0.45013063
87	CDK3	0.43077787
88	PRKCH	0.41844126
89	CSNK1G1	0.41727401
90	CDK9	0.41242945
91	ADRBK1	0.40560094
92	KIT	0.39075892
93	BRD4	0.37516555
94	PRKCI	0.37408824
95	PRKDC	0.37360833
96	DAPK3	0.35638025
97	MAPK13	0.35326452
98	PASK	0.34607424
99	STK10	0.33993088
100	PRKACB	0.33578088

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.14829028
2	Protein export_Homo sapiens_hsa03060	3.98578594
3	Proteasome_Homo sapiens_hsa03050	3.38868738
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.26929360
5	Ribosome_Homo sapiens_hsa03010	3.08669737
6	Mismatch repair_Homo sapiens_hsa03430	2.87286489
7	RNA polymerase_Homo sapiens_hsa03020	2.84944559
8	Parkinsons disease_Homo sapiens_hsa05012	2.71858439
9	DNA replication_Homo sapiens_hsa03030	2.71440569
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.66764229
11	Basal transcription factors_Homo sapiens_hsa03022	2.47706799
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.16835591
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15705374
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.99282833
15	Huntingtons disease_Homo sapiens_hsa05016	1.94603205
16	Sulfur relay system_Homo sapiens_hsa04122	1.92343452
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.80701322
18	RNA degradation_Homo sapiens_hsa03018	1.79988794
19	Alzheimers disease_Homo sapiens_hsa05010	1.72496982
20	RNA transport_Homo sapiens_hsa03013	1.69892543
21	Spliceosome_Homo sapiens_hsa03040	1.68060471
22	Asthma_Homo sapiens_hsa05310	1.55778904
23	One carbon pool by folate_Homo sapiens_hsa00670	1.52722079
24	Base excision repair_Homo sapiens_hsa03410	1.49238423
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38553860
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33883553
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27049199
28	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16325369
29	Phototransduction_Homo sapiens_hsa04744	1.15750131
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15480537
31	Purine metabolism_Homo sapiens_hsa00230	1.12666127
32	Galactose metabolism_Homo sapiens_hsa00052	1.11642658
33	Caffeine metabolism_Homo sapiens_hsa00232	1.11108491
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11044555
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.07175249
36	Olfactory transduction_Homo sapiens_hsa04740	1.05685083
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.03135521
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.01732166
39	Cell cycle_Homo sapiens_hsa04110	0.95439886
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94503187
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94057821
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91529470
43	Sulfur metabolism_Homo sapiens_hsa00920	0.91431476
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87318314
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81183755
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80718334
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80119835
48	Folate biosynthesis_Homo sapiens_hsa00790	0.79433320
49	Propanoate metabolism_Homo sapiens_hsa00640	0.75575647
50	Allograft rejection_Homo sapiens_hsa05330	0.73581640
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71357798
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71045202
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.70667218
54	Nicotine addiction_Homo sapiens_hsa05033	0.69492621
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.68459330
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67253969
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66797307
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66319082
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66299641
60	Oocyte meiosis_Homo sapiens_hsa04114	0.65229384
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62657000
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61364308
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.60240669
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60055234
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59539969
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.59297180
67	Fatty acid degradation_Homo sapiens_hsa00071	0.59168279
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56155786
69	Melanoma_Homo sapiens_hsa05218	0.55799373
70	Retinol metabolism_Homo sapiens_hsa00830	0.53156620
71	Metabolic pathways_Homo sapiens_hsa01100	0.48560572
72	Taste transduction_Homo sapiens_hsa04742	0.45675825
73	p53 signaling pathway_Homo sapiens_hsa04115	0.42940292
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.40628208
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40251410
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38516621
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37832163
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35971538
79	Regulation of autophagy_Homo sapiens_hsa04140	0.35850621
80	Mineral absorption_Homo sapiens_hsa04978	0.35423518
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.35263493
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.33824991
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32372772
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31828312
85	Morphine addiction_Homo sapiens_hsa05032	0.30721357
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.30218480
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.29492424
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29384630
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26867115
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.26699163
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.25533736
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.25386843
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22737852
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.21261406
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20809970
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.17731472
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.17429913
98	Serotonergic synapse_Homo sapiens_hsa04726	0.15316065
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.14861904
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.13551536

EIF2S2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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